
                                SEQUENCE LISTING

<110> THE J. DAVID GLADSTONE INSTITUTES
      FINKBEINER, STEVEN M.
      Carter, Sarah Rosemary
      Kim, Hong Joo
      LaDow, Eva Suzanne
      Rao, Vikram Ramnath

<120> Compositions and Methods for Treating
  Neurological Disorders

<130> GLAD-387WO

<150> US 61/317,598       
<151> 2010-03-25  

<160> 38

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 912
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Ala Pro Pro Val Leu Arg Pro Pro Ser Pro Leu Leu Pro Val
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Val Pro Gly Ser Gly
            20                  25                  30          
Pro Gly Pro Ala Pro Phe Leu Ala Pro Val Ala Ala Pro Val Gly Gly
        35                  40                  45              
Ile Ser Phe His Leu Gln Ile Gly Leu Ser Arg Glu Pro Val Leu Leu
    50                  55                  60                  
Leu Gln Asp Ser Ser Gly Asp Tyr Ser Leu Ala His Val Arg Glu Met
65                  70                  75                  80  
Ala Cys Ser Ile Val Asp Gln Lys Phe Pro Glu Cys Gly Phe Tyr Gly
                85                  90                  95      
Met Tyr Asp Lys Ile Leu Leu Phe Arg His Asp Pro Thr Ser Glu Asn
            100                 105                 110         
Ile Leu Gln Leu Val Lys Ala Ala Ser Asp Ile Gln Glu Gly Asp Leu
        115                 120                 125             
Ile Glu Val Val Leu Ser Ala Ser Ala Thr Phe Glu Asp Phe Gln Ile
    130                 135                 140                 
Arg Pro His Ala Leu Phe Val His Ser Tyr Arg Ala Pro Ala Phe Cys
145                 150                 155                 160 
Asp His Cys Gly Glu Met Leu Trp Gly Leu Val Arg Gln Gly Leu Lys
                165                 170                 175     
Cys Glu Gly Cys Gly Leu Asn Tyr His Lys Arg Cys Ala Phe Lys Ile
            180                 185                 190         
Pro Asn Asn Cys Ser Gly Val Arg Arg Arg Arg Leu Ser Asn Val Ser
        195                 200                 205             
Leu Thr Gly Val Ser Thr Ile Arg Thr Ser Ser Ala Glu Leu Ser Thr
    210                 215                 220                 
Ser Ala Pro Asp Glu Pro Leu Leu Gln Lys Ser Pro Ser Glu Ser Phe
225                 230                 235                 240 
Ile Gly Arg Glu Lys Arg Ser Asn Ser Gln Ser Tyr Ile Gly Arg Pro
                245                 250                 255     
Ile His Leu Asp Lys Ile Leu Met Ser Lys Val Lys Val Pro His Thr
            260                 265                 270         
Phe Val Ile His Ser Tyr Thr Arg Pro Thr Val Cys Gln Tyr Cys Lys
        275                 280                 285             
Lys Leu Leu Lys Gly Leu Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys
    290                 295                 300                 
Arg Phe Asn Cys His Lys Arg Cys Ala Pro Lys Val Pro Asn Asn Cys
305                 310                 315                 320 
Leu Gly Glu Val Thr Ile Asn Gly Asp Leu Leu Ser Pro Gly Ala Glu
                325                 330                 335     
Ser Asp Val Val Met Glu Glu Gly Ser Asp Asp Asn Asp Ser Glu Arg
            340                 345                 350         
Asn Ser Gly Leu Met Asp Asp Met Glu Glu Ala Met Val Gln Asp Ala
        355                 360                 365             
Glu Met Ala Met Ala Glu Cys Gln Asn Asp Ser Gly Glu Met Gln Asp
    370                 375                 380                 
Pro Asp Pro Asp His Glu Asp Ala Asn Arg Thr Ile Ser Pro Ser Thr
385                 390                 395                 400 
Ser Asn Asn Ile Pro Leu Met Arg Val Val Gln Ser Val Lys His Thr
                405                 410                 415     
Lys Arg Lys Ser Ser Thr Val Met Lys Glu Gly Trp Met Val His Tyr
            420                 425                 430         
Thr Ser Lys Asp Thr Leu Arg Lys Arg His Tyr Trp Arg Leu Asp Ser
        435                 440                 445             
Lys Cys Ile Thr Leu Phe Gln Asn Asp Thr Gly Ser Arg Tyr Tyr Lys
    450                 455                 460                 
Glu Ile Pro Leu Ser Glu Ile Leu Ser Leu Glu Pro Val Lys Thr Ser
465                 470                 475                 480 
Ala Leu Ile Pro Asn Gly Ala Asn Pro His Cys Phe Glu Ile Thr Thr
                485                 490                 495     
Ala Asn Val Val Tyr Tyr Val Gly Glu Asn Val Val Asn Pro Ser Ser
            500                 505                 510         
Pro Ser Pro Asn Asn Ser Val Leu Thr Ser Gly Val Gly Ala Asp Val
        515                 520                 525             
Ala Arg Met Trp Glu Ile Ala Ile Gln His Ala Leu Met Pro Val Ile
    530                 535                 540                 
Pro Lys Gly Ser Ser Val Gly Thr Gly Thr Asn Leu His Arg Asp Ile
545                 550                 555                 560 
Ser Val Ser Ile Ser Val Ser Asn Cys Gln Ile Gln Glu Asn Val Asp
                565                 570                 575     
Ile Ser Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly
            580                 585                 590         
Gln Phe Gly Ile Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp
        595                 600                 605             
Val Ala Ile Lys Ile Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu
    610                 615                 620                 
Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Asn Leu His His Pro
625                 630                 635                 640 
Gly Val Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Arg Val Phe
                645                 650                 655     
Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser
            660                 665                 670         
Ser Glu Lys Gly Arg Leu Pro Glu His Ile Thr Lys Phe Leu Ile Thr
        675                 680                 685             
Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His
    690                 695                 700                 
Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe
705                 710                 715                 720 
Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu
                725                 730                 735     
Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro
            740                 745                 750         
Glu Val Leu Arg Asn Lys Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser
        755                 760                 765             
Val Gly Val Ile Ile Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn
    770                 775                 780                 
Glu Asp Glu Asp Ile His Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr
785                 790                 795                 800 
Pro Pro Asn Pro Trp Lys Glu Ile Ser His Glu Ala Ile Asp Leu Ile
                805                 810                 815     
Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys
            820                 825                 830         
Thr Leu Ser His Pro Trp Leu Gln Asp Tyr Gln Thr Trp Leu Asp Leu
        835                 840                 845             
Arg Glu Leu Glu Cys Lys Ile Gly Glu Arg Tyr Ile Thr His Glu Ser
    850                 855                 860                 
Asp Asp Leu Arg Trp Glu Lys Tyr Ala Gly Glu Gln Gly Leu Gln Tyr
865                 870                 875                 880 
Pro Thr His Leu Ile Asn Pro Ser Ala Ser His Ser Asp Thr Pro Glu
                885                 890                 895     
Thr Glu Glu Thr Glu Met Lys Ala Leu Gly Glu Arg Val Ser Ile Leu
            900                 905                 910         


<210> 2
<211> 2739
<212> DNA
<213> Homo sapiens

<400> 2
atgagcgccc ctccggtcct gcggccgccc agtccgctgc tgcccgtggc ggcggcagct 60
gccgcagcgg ccgccgcact ggtcccaggg tccgggcccg ggcccgcgcc gttcttggct 120
cctgtcgcgg ccccggtcgg gggcatctcg ttccatctgc agatcggcct gagccgtgag 180
ccggtgctgc tgctgcagga ctcgtccggg gactacagcc tggcgcacgt ccgcgagatg 240
gcttgctcca ttgtcgacca gaagttccct gaatgtggtt tctacggaat gtatgataag 300
atcctgcttt ttcgccatga ccctacctct gaaaacatcc ttcagctggt gaaagcggcc 360
agtgatatcc aggaaggcga tcttattgaa gtggtcttgt cagcttccgc cacctttgaa 420
gactttcaga ttcgtcccca cgctctcttt gttcattcat acagagctcc agctttctgt 480
gatcactgtg gagaaatgct gtgggggctg gtacgtcaag gtcttaaatg tgaagggtgt 540
ggtctgaatt accataagag atgtgcattt aaaataccca acaattgcag cggtgtgagg 600
cggagaaggc tctcaaacgt ttccctcact ggggtcagca ccatccgcac atcatctgct 660
gaactctcta caagtgcccc tgatgagccc cttctgcaaa aatcaccatc agagtcgttt 720
attggtcgag agaagaggtc aaattctcaa tcatacattg gacgaccaat tcaccttgac 780
aagattttga tgtctaaagt taaagtgccg cacacatttg tcatccactc ctacacccgg 840
cccacagtgt gccagtactg caagaagctt ctgaaggggc ttttcaggca gggcttgcag 900
tgcaaagatt gcagattcaa ctgccataaa cgttgtgcac cgaaagtacc aaacaactgc 960
cttggcgaag tgaccattaa tggagatttg cttagccctg gggcagagtc tgatgtggtc 1020
atggaagaag ggagtgatga caatgatagt gaaaggaaca gtgggctcat ggatgatatg 1080
gaagaagcaa tggtccaaga tgcagagatg gcaatggcag agtgccagaa cgacagtggc 1140
gagatgcaag atccagaccc agaccacgag gacgccaaca gaaccatcag tccatcaaca 1200
agcaacaata tcccactcat gagggtagtg cagtctgtca aacacacgaa gaggaaaagc 1260
agcacagtca tgaaagaagg atggatggtc cactacacca gcaaggacac gctgcggaaa 1320
cggcactatt ggagattgga tagcaaatgt attaccctct ttcagaatga cacaggaagc 1380
aggtactaca aggaaattcc tttatctgaa attttgtctc tggaaccagt aaaaacttca 1440
gctttaattc ctaatggggc caatcctcat tgtttcgaaa tcactacggc aaatgtagtg 1500
tattatgtgg gagaaaatgt ggtcaatcct tccagcccat caccaaataa cagtgttctc 1560
accagtggcg ttggtgcaga tgtggccagg atgtgggaga tagccatcca gcatgccctt 1620
atgcccgtca ttcccaaggg ctcctccgtg ggtacaggaa ccaacttgca cagagatatc 1680
tctgtgagta tttcagtatc aaattgccag attcaagaaa atgtggacat cagcacagta 1740
tatcagattt ttcctgatga agtactgggt tctggacagt ttggaattgt ttatggagga 1800
aaacatcgta aaacaggaag agatgtagct attaaaatca ttgacaaatt acgatttcca 1860
acaaaacaag aaagccagct tcgtaatgag gttgcaattc tacagaacct tcatcaccct 1920
ggtgttgtaa atttggagtg tatgtttgag acgcctgaaa gagtgtttgt tgttatggaa 1980
aaactccatg gagacatgct ggaaatgatc ttgtcaagtg aaaagggcag gttgccagag 2040
cacataacga agtttttaat tactcagata ctcgtggctt tgcggcacct tcattttaaa 2100
aatatcgttc actgtgacct caaaccagaa aatgtgttgc tagcctcagc tgatcctttt 2160
cctcaggtga aactttgtga ttttggtttt gcccggatca ttggagagaa gtctttccgg 2220
aggtcagtgg tgggtacccc cgcttacctg gctcctgagg tcctaaggaa caagggctac 2280
aatcgctctc tagacatgtg gtctgttggg gtcatcatct atgtaagcct aagcggcaca 2340
ttcccattta atgaagatga agacatacac gaccaaattc agaatgcagc tttcatgtat 2400
ccaccaaatc cctggaagga aatatctcat gaagccattg atcttatcaa caatttgctg 2460
caagtaaaaa tgagaaagcg ctacagtgtg gataagacct tgagccaccc ttggctacag 2520
gactatcaga cctggttaga tttgcgagag ctggaatgca aaatcgggga gcgctacatc 2580
acccatgaaa gtgatgacct gaggtgggag aagtatgcag gcgagcaggg gctgcagtac 2640
cccacacacc tgatcaatcc aagtgctagc cacagtgaca ctcctgagac tgaagaaaca 2700
gaaatgaaag ccctcggtga gcgtgtcagc atcctctga                        2739

<210> 3
<211> 59
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 3
Ser Asn Val Ser Leu Thr Gly Leu Gly Thr Val Arg Thr Ala Ser Ala
 1               5                  10                  15      
Glu Phe Ser Thr Ser Val Pro Asp Glu Pro Leu Leu Ser Pro Val Ser
            20                  25                  30          
Pro Gly Phe Glu Gln Lys Ser Pro Ser Glu Ser Phe Ile Gly Arg Glu
        35                  40                  45              
Lys Arg Ser Asn Ser Gln Ser Tyr Ile Gly Arg
    50                  55                  


<210> 4
<211> 78
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 4
Asn Gly Glu Leu Leu Ser Pro Gly Ala Glu Ser Asp Val Val Met Glu
 1               5                  10                  15      
Glu Gly Ser Asp Asp Asn Asp Ser Glu Arg Asn Ser Gly Leu Met Asp
            20                  25                  30          
Asp Met Asp Glu Ala Met Val Gln Asp Thr Glu Met Ala Leu Ala Glu
        35                  40                  45              
Gly Gln Ser Gly Gly Ala Glu Met Gln Asp Pro Asp Ala Asp Gln Glu
    50                  55                  60                  
Asp Ser Asn Arg Thr Ile Ser Pro Ser Thr Ser Asn Asn Ile
65                  70                  75              


<210> 5
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 5
Trp Glu Gln Tyr Ala Gly Glu Gln Gly Leu Gln Tyr Pro Ala His Leu
 1               5                  10                  15      
Ile Ser Leu Ser Ala Ser His Ser Asp Ser Pro Glu Ala Glu Glu Arg
            20                  25                  30          
Glu Met Lys Ala Leu Ser Glu Arg Val Ser Ile Leu
        35                  40                  


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 6
Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
 1               5                  10  


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 7
Asp Tyr Lys Asp Asp Asp Asp Lys
 1               5              


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 8
Cys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu
 1               5                  10      


<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 9
His His His His His
 1               5  


<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 10
His His His His His His
 1               5      


<210> 11
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 11
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu
 1               5                  10  


<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 12
Trp Ser His Pro Gln Phe Glu Lys
 1               5              


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 13
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
 1               5                  


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 14
Arg Tyr Ile Arg Ser
 1               5  


<210> 15
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 15
Phe His His Thr
 1              


<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 16
Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg
 1               5                  10                  15      
Ala
    


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 17
aaagagtgtt tgttgttatg g                                           21

<210> 18
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 18
acgcctgaaa gagtgtttgt tgttatggaa                                  30

<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 19
acgcctgaaa gagtgtttgt                                             20

<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 20
gagtgtttgt tgttatggaa                                             20

<210> 21
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 21
gagtgtttgt tgttatggaa aaactccatg                                  30

<210> 22
<211> 80
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 22
Met Ala Ala Ala Pro Ser His Pro Ala Gly Leu Pro Gly Ser Pro Gly
 1               5                  10                  15      
Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Asp Leu Gln Ser Pro Pro
            20                  25                  30          
Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His
        35                  40                  45              
Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser
    50                  55                  60                  
Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys
65                  70                  75                  80  


<210> 23
<211> 80
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 23
Met Ser Ala Asn Asn Ser Pro Pro Ser Ala Gln Lys Ser Val Phe Pro
 1               5                  10                  15      
Ala Thr Val Ser Ala Val Leu Pro Ala Pro Ser Pro Cys Ser Ser Pro
            20                  25                  30          
Lys Thr Gly Leu Ser Ala Arg Leu Ser Asn Gly Ser Phe Ser Ala Pro
        35                  40                  45              
Ser Leu Thr Asn Ser Arg Gly Ser Val His Thr Val Ser Phe Leu Leu
    50                  55                  60                  
Gln Ile Gly Leu Thr Arg Glu Ser Val Thr Ile Glu Ala Gln Glu Leu
65                  70                  75                  80  


<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 24
aaagtgtgat tgttgtttag g                                           21

<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 25
cctgagccac ctggaagagt a                                           21

<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 26
ggcccattca tgtggttctg                                             20

<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 27
ctgtgacctc aagccagaaa                                             20

<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 28
gtacccacca ctgacctcct                                             20

<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 29
catcgacctc atcaacaacc                                             20

<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 30
tggctgagag acttgtccac                                             20

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 31
cccagaaatc tgtgttccct                                             20

<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 32
agagagccga gctgagagtc                                             20

<210> 33
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 33
ccccaatgtg tccgtcgt                                               18

<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 34
gcctgcttca ccaccttct                                              19

<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 35
ccctgcaccg tgtatcttag agtg                                        24

<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 36
tccacccttg caactaattt g                                           21

<210> 37
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 37
taacctggtg tccctcctgg atc                                         23

<210> 38
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 38
gcaaagactt ctcagcagcc ttga                                        24
