                         SEQUENCE LISTING

<110>  PRONOTA N.V.
 
<120>  LTBP2 AS A BIOMARKER FOR RENAL DYSFUNCTION

<130>  PRNO-032-PCT

<150>  10158061.1
<151>  2010-03-26

<150>  61/318,064
<151>  2010-03-26

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  1821
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Arg Thr Lys Ala Arg Ser Pro Gly Arg Ala Leu Arg Asn 
1               5                   10                  15      


Pro Trp Arg Gly Phe Leu Pro Leu Thr Leu Ala Leu Phe Val Gly Ala 
            20                  25                  30          


Gly His Ala Gln Arg Asp Pro Val Gly Arg Tyr Glu Pro Ala Gly Gly 
        35                  40                  45              


Asp Ala Asn Arg Leu Arg Arg Pro Gly Gly Ser Tyr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Lys Val Tyr Ser Leu Phe Arg Glu Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Glu Arg Ala Gln Pro Gly Trp Gly Ser Pro Arg 
                85                  90                  95      


Arg Pro Thr Glu Ala Glu Ala Arg Arg Pro Ser Arg Ala Gln Gln Ser 
            100                 105                 110         


Arg Arg Val Gln Pro Pro Ala Gln Thr Arg Arg Ser Thr Pro Leu Gly 
        115                 120                 125             


Gln Gln Gln Pro Ala Pro Arg Thr Arg Ala Ala Pro Ala Leu Pro Arg 
    130                 135                 140                 


Leu Gly Thr Pro Gln Arg Ser Gly Ala Ala Pro Pro Thr Pro Pro Arg 
145                 150                 155                 160 


Gly Arg Leu Thr Gly Arg Asn Val Cys Gly Gly Gln Cys Cys Pro Gly 
                165                 170                 175     


Trp Thr Thr Ala Asn Ser Thr Asn His Cys Ile Lys Pro Val Cys Glu 
            180                 185                 190         


Pro Pro Cys Gln Asn Arg Gly Ser Cys Ser Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Arg Ser Gly Phe Arg Gly Ala Arg Cys Glu Glu Val Ile Pro Asp 
    210                 215                 220                 


Glu Glu Phe Asp Pro Gln Asn Ser Arg Leu Ala Pro Arg Arg Trp Ala 
225                 230                 235                 240 


Glu Arg Ser Pro Asn Leu Arg Arg Ser Ser Ala Ala Gly Glu Gly Thr 
                245                 250                 255     


Leu Ala Arg Ala Gln Pro Pro Ala Pro Gln Ser Pro Pro Ala Pro Gln 
            260                 265                 270         


Ser Pro Pro Ala Gly Thr Leu Ser Gly Leu Ser Gln Thr His Pro Ser 
        275                 280                 285             


Gln Gln His Val Gly Leu Ser Arg Thr Val Arg Leu His Pro Thr Ala 
    290                 295                 300                 


Thr Ala Ser Ser Gln Leu Ser Ser Asn Ala Leu Pro Pro Gly Pro Gly 
305                 310                 315                 320 


Leu Glu Gln Arg Asp Gly Thr Gln Gln Ala Val Pro Leu Glu His Pro 
                325                 330                 335     


Ser Ser Pro Trp Gly Leu Asn Leu Thr Glu Lys Ile Lys Lys Ile Lys 
            340                 345                 350         


Ile Val Phe Thr Pro Thr Ile Cys Lys Gln Thr Cys Ala Arg Gly His 
        355                 360                 365             


Cys Ala Asn Ser Cys Glu Arg Gly Asp Thr Thr Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Gly Gly His Gly His Asp Pro Lys Ser Gly Phe Arg Ile Tyr Phe Cys 
385                 390                 395                 400 


Gln Ile Pro Cys Leu Asn Gly Gly Arg Cys Ile Gly Arg Asp Glu Cys 
                405                 410                 415     


Trp Cys Pro Ala Asn Ser Thr Gly Lys Phe Cys His Leu Pro Ile Pro 
            420                 425                 430         


Gln Pro Asp Arg Glu Pro Pro Gly Arg Gly Ser Arg Pro Arg Ala Leu 
        435                 440                 445             


Leu Glu Ala Pro Leu Lys Gln Ser Thr Phe Thr Leu Pro Leu Ser Asn 
    450                 455                 460                 


Gln Leu Ala Ser Val Asn Pro Ser Leu Val Lys Val His Ile His His 
465                 470                 475                 480 


Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ala Gln Val Arg Gly 
                485                 490                 495     


Gly Val Glu Glu Ala Leu Val Glu Asn Ser Val Glu Thr Arg Pro Pro 
            500                 505                 510         


Pro Trp Leu Pro Ala Ser Pro Gly His Ser Leu Trp Asp Ser Asn Asn 
        515                 520                 525             


Ile Pro Ala Arg Ser Gly Glu Pro Pro Arg Pro Leu Pro Pro Ala Ala 
    530                 535                 540                 


Pro Arg Pro Arg Gly Leu Leu Gly Arg Cys Tyr Leu Asn Thr Val Asn 
545                 550                 555                 560 


Gly Gln Cys Ala Asn Pro Leu Leu Glu Leu Thr Thr Gln Glu Asp Cys 
                565                 570                 575     


Cys Gly Ser Val Gly Ala Phe Trp Gly Val Thr Leu Cys Ala Pro Cys 
            580                 585                 590         


Pro Pro Arg Pro Ala Ser Pro Val Ile Glu Asn Gly Gln Leu Glu Cys 
        595                 600                 605             


Pro Gln Gly Tyr Lys Arg Leu Asn Leu Thr His Cys Gln Asp Ile Asn 
    610                 615                 620                 


Glu Cys Leu Thr Leu Gly Leu Cys Lys Asp Ala Glu Cys Val Asn Thr 
625                 630                 635                 640 


Arg Gly Ser Tyr Leu Cys Thr Cys Arg Pro Gly Leu Met Leu Asp Pro 
                645                 650                 655     


Ser Arg Ser Arg Cys Val Ser Asp Lys Ala Ile Ser Met Leu Gln Gly 
            660                 665                 670         


Leu Cys Tyr Arg Ser Leu Gly Pro Gly Thr Cys Thr Leu Pro Leu Ala 
        675                 680                 685             


Gln Arg Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly Lys Ala 
    690                 695                 700                 


Trp Gly Ser Glu Cys Glu Lys Cys Pro Leu Pro Gly Thr Glu Ala Phe 
705                 710                 715                 720 


Arg Glu Ile Cys Pro Ala Gly His Gly Tyr Thr Tyr Ala Ser Ser Asp 
                725                 730                 735     


Ile Arg Leu Ser Met Arg Lys Ala Glu Glu Glu Glu Leu Ala Arg Pro 
            740                 745                 750         


Pro Arg Glu Gln Gly Gln Arg Ser Ser Gly Ala Leu Pro Gly Pro Ala 
        755                 760                 765             


Glu Arg Gln Pro Leu Arg Val Val Thr Asp Thr Trp Leu Glu Ala Gly 
    770                 775                 780                 


Thr Ile Pro Asp Lys Gly Asp Ser Gln Ala Gly Gln Val Thr Thr Ser 
785                 790                 795                 800 


Val Thr His Ala Pro Ala Trp Val Thr Gly Asn Ala Thr Thr Pro Pro 
                805                 810                 815     


Met Pro Glu Gln Gly Ile Ala Glu Ile Gln Glu Glu Gln Val Thr Pro 
            820                 825                 830         


Ser Thr Asp Val Leu Val Thr Leu Ser Thr Pro Gly Ile Asp Arg Cys 
        835                 840                 845             


Ala Ala Gly Ala Thr Asn Val Cys Gly Pro Gly Thr Cys Val Asn Leu 
    850                 855                 860                 


Pro Asp Gly Tyr Arg Cys Val Cys Ser Pro Gly Tyr Gln Leu His Pro 
865                 870                 875                 880 


Ser Gln Ala Tyr Cys Thr Asp Asp Asn Glu Cys Leu Arg Asp Pro Cys 
                885                 890                 895     


Lys Gly Lys Gly Arg Cys Ile Asn Arg Val Gly Ser Tyr Ser Cys Phe 
            900                 905                 910         


Cys Tyr Pro Gly Tyr Thr Leu Ala Thr Ser Gly Ala Thr Gln Glu Cys 
        915                 920                 925             


Gln Asp Ile Asn Glu Cys Glu Gln Pro Gly Val Cys Ser Gly Gly Gln 
    930                 935                 940                 


Cys Thr Asn Thr Glu Gly Ser Tyr His Cys Glu Cys Asp Gln Gly Tyr 
945                 950                 955                 960 


Ile Met Val Arg Lys Gly His Cys Gln Asp Ile Asn Glu Cys Arg His 
                965                 970                 975     


Pro Gly Thr Cys Pro Asp Gly Arg Cys Val Asn Ser Pro Gly Ser Tyr 
            980                 985                 990         


Thr Cys Leu Ala Cys Glu Glu Gly  Tyr Arg Gly Gln Ser  Gly Ser Cys 
        995                 1000                 1005             


Val Asp  Val Asn Glu Cys Leu  Thr Pro Gly Val Cys  Ala His Gly 
    1010                 1015                 1020             


Lys Cys  Thr Asn Leu Glu Gly  Ser Phe Arg Cys Ser  Cys Glu Gln 
    1025                 1030                 1035             


Gly Tyr  Glu Val Thr Ser Asp  Glu Lys Gly Cys Gln  Asp Val Asp 
    1040                 1045                 1050             


Glu Cys  Ala Ser Arg Ala Ser  Cys Pro Thr Gly Leu  Cys Leu Asn 
    1055                 1060                 1065             


Thr Glu  Gly Ser Phe Ala Cys  Ser Ala Cys Glu Asn  Gly Tyr Trp 
    1070                 1075                 1080             


Val Asn  Glu Asp Gly Thr Ala  Cys Glu Asp Leu Asp  Glu Cys Ala 
    1085                 1090                 1095             


Phe Pro  Gly Val Cys Pro Ser  Gly Val Cys Thr Asn  Thr Ala Gly 
    1100                 1105                 1110             


Ser Phe  Ser Cys Lys Asp Cys  Asp Gly Gly Tyr Arg  Pro Ser Pro 
    1115                 1120                 1125             


Leu Gly  Asp Ser Cys Glu Asp  Val Asp Glu Cys Glu  Asp Pro Gln 
    1130                 1135                 1140             


Ser Ser  Cys Leu Gly Gly Glu  Cys Lys Asn Thr Val  Gly Ser Tyr 
    1145                 1150                 1155             


Gln Cys  Leu Cys Pro Gln Gly  Phe Gln Leu Ala Asn  Gly Thr Val 
    1160                 1165                 1170             


Cys Glu  Asp Val Asn Glu Cys  Met Gly Glu Glu His  Cys Ala Pro 
    1175                 1180                 1185             


His Gly  Glu Cys Leu Asn Ser  His Gly Ser Phe Phe  Cys Leu Cys 
    1190                 1195                 1200             


Ala Pro  Gly Phe Val Ser Ala  Glu Gly Gly Thr Ser  Cys Gln Asp 
    1205                 1210                 1215             


Val Asp  Glu Cys Ala Thr Thr  Asp Pro Cys Val Gly  Gly His Cys 
    1220                 1225                 1230             


Val Asn  Thr Glu Gly Ser Phe  Asn Cys Leu Cys Glu  Thr Gly Phe 
    1235                 1240                 1245             


Gln Pro  Ser Pro Glu Ser Gly  Glu Cys Val Asp Ile  Asp Glu Cys 
    1250                 1255                 1260             


Glu Asp  Tyr Gly Asp Pro Val  Cys Gly Thr Trp Lys  Cys Glu Asn 
    1265                 1270                 1275             


Ser Pro  Gly Ser Tyr Arg Cys  Val Leu Gly Cys Gln  Pro Gly Phe 
    1280                 1285                 1290             


His Met  Ala Pro Asn Gly Asp  Cys Ile Asp Ile Asp  Glu Cys Ala 
    1295                 1300                 1305             


Asn Asp  Thr Met Cys Gly Ser  His Gly Phe Cys Asp  Asn Thr Asp 
    1310                 1315                 1320             


Gly Ser  Phe Arg Cys Leu Cys  Asp Gln Gly Phe Glu  Ile Ser Pro 
    1325                 1330                 1335             


Ser Gly  Trp Asp Cys Val Asp  Val Asn Glu Cys Glu  Leu Met Leu 
    1340                 1345                 1350             


Ala Val  Cys Gly Ala Ala Leu  Cys Glu Asn Val Glu  Gly Ser Phe 
    1355                 1360                 1365             


Leu Cys  Leu Cys Ala Ser Asp  Leu Glu Glu Tyr Asp  Ala Gln Glu 
    1370                 1375                 1380             


Gly His  Cys Arg Pro Arg Gly  Ala Gly Gly Gln Ser  Met Ser Glu 
    1385                 1390                 1395             


Ala Pro  Thr Gly Asp His Ala  Pro Ala Pro Thr Arg  Met Asp Cys 
    1400                 1405                 1410             


Tyr Ser  Gly Gln Lys Gly His  Ala Pro Cys Ser Ser  Val Leu Gly 
    1415                 1420                 1425             


Arg Asn  Thr Thr Gln Ala Glu  Cys Cys Cys Thr Gln  Gly Ala Ser 
    1430                 1435                 1440             


Trp Gly  Asp Ala Cys Asp Leu  Cys Pro Ser Glu Asp  Ser Ala Glu 
    1445                 1450                 1455             


Phe Ser  Glu Ile Cys Pro Ser  Gly Lys Gly Tyr Ile  Pro Val Glu 
    1460                 1465                 1470             


Gly Ala  Trp Thr Phe Gly Gln  Thr Met Tyr Thr Asp  Ala Asp Glu 
    1475                 1480                 1485             


Cys Val  Ile Phe Gly Pro Gly  Leu Cys Pro Asn Gly  Arg Cys Leu 
    1490                 1495                 1500             


Asn Thr  Val Pro Gly Tyr Val  Cys Leu Cys Asn Pro  Gly Phe His 
    1505                 1510                 1515             


Tyr Asp  Ala Ser His Lys Lys  Cys Glu Asp His Asp  Glu Cys Gln 
    1520                 1525                 1530             


Asp Leu  Ala Cys Glu Asn Gly  Glu Cys Val Asn Thr  Glu Gly Ser 
    1535                 1540                 1545             


Phe His  Cys Phe Cys Ser Pro  Pro Leu Thr Leu Asp  Leu Ser Gln 
    1550                 1555                 1560             


Gln Arg  Cys Met Asn Ser Thr  Ser Ser Thr Glu Asp  Leu Pro Asp 
    1565                 1570                 1575             


His Asp  Ile His Met Asp Ile  Cys Trp Lys Lys Val  Thr Asn Asp 
    1580                 1585                 1590             


Val Cys  Ser Glu Pro Leu Arg  Gly His Arg Thr Thr  Tyr Thr Glu 
    1595                 1600                 1605             


Cys Cys  Cys Gln Asp Gly Glu  Ala Trp Ser Gln Gln  Cys Ala Leu 
    1610                 1615                 1620             


Cys Pro  Pro Arg Ser Ser Glu  Val Tyr Ala Gln Leu  Cys Asn Val 
    1625                 1630                 1635             


Ala Arg  Ile Glu Ala Glu Arg  Glu Ala Gly Val His  Phe Arg Pro 
    1640                 1645                 1650             


Gly Tyr  Glu Tyr Gly Pro Gly  Pro Asp Asp Leu His  Tyr Ser Ile 
    1655                 1660                 1665             


Tyr Gly  Pro Asp Gly Ala Pro  Phe Tyr Asn Tyr Leu  Gly Pro Glu 
    1670                 1675                 1680             


Asp Thr  Val Pro Glu Pro Ala  Phe Pro Asn Thr Ala  Gly His Ser 
    1685                 1690                 1695             


Ala Asp  Arg Thr Pro Ile Leu  Glu Ser Pro Leu Gln  Pro Ser Glu 
    1700                 1705                 1710             


Leu Gln  Pro His Tyr Val Ala  Ser His Pro Glu Pro  Pro Ala Gly 
    1715                 1720                 1725             


Phe Glu  Gly Leu Gln Ala Glu  Glu Cys Gly Ile Leu  Asn Gly Cys 
    1730                 1735                 1740             


Glu Asn  Gly Arg Cys Val Arg  Val Arg Glu Gly Tyr  Thr Cys Asp 
    1745                 1750                 1755             


Cys Phe  Glu Gly Phe Gln Leu  Asp Ala Ala His Met  Ala Cys Val 
    1760                 1765                 1770             


Asp Val  Asn Glu Cys Asp Asp  Leu Asn Gly Pro Ala  Val Leu Cys 
    1775                 1780                 1785             


Val His  Gly Tyr Cys Glu Asn  Thr Glu Gly Ser Tyr  Arg Cys His 
    1790                 1795                 1800             


Cys Ser  Pro Gly Tyr Val Ala  Glu Ala Gly Pro Pro  His Cys Thr 
    1805                 1810                 1815             


Ala Lys  Glu 
    1820     


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Gln Asp Ala Pro Val Ala Gly Leu Gln Pro Val Glu Arg 
1               5                   10                  


