                         SEQUENCE LISTING

<110>  HORLICK, ROBERT
       MACOMBER, JOHN L.
       CUBITT, ANDREW
       KING, DAVID J.
 
<120>  METHOD OF PRODUCING TRANSCRIPTS USING CRYPTIC SPLICE SITES

<130>  707758

<140>  PCT/US2011/028529
<141>  2011-03-15

<150>  61/314,811
<151>  2010-03-17

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
ctccgggtaa actcgagata                                                   20


<210>  2
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
ctccaggtaa actcgag                                                      17


<210>  3
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
acccaggtac cacggtt                                                      17


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
gtgacaaacg ggtaaacctc gagat                                             25


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
gtgacaaaca ggtaaacctc gagat                                             25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
gtgacaaaca ggtaccactc gagat                                             25


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gtgacaaaca ggtaaatctc gagat                                             25


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
aaacaggtaa atctcgagat                                                   20


<210>  9
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
gccaccatgg agtttgggct ga                                                22


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
ctattactaa acacagcatg                                                   20


<210>  12
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  13
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
tatgaagctt ggatatacta agcttcata                                         29


<210>  14
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
atcacctcat acagcataca ttatacaaag ttat                                   34


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

His His His His His His His His His 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
1               5                   


<210>  17
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
cttgtgaca                                                                9


<210>  18
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
caggtaaat                                                                9


<210>  19
<211>  1940
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
atggaattgg ggctgagctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagttgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagtaac cattggatga actgggtccg ccagactcca      180

gggaaagggc tggagtgggt ggccgccata aacgaagatg gaagtgagaa atactatgtg      240

ggctctgtga aggtccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagt cgaggacacg gctgtgtatt actgtgcaag agattactat      360

gatatactta cagattacta catacactac tggtacttcg atctctgggg ccgtggcacc      420

ctggtcactg tctcctcagc ctccaccaag ggcccatcgg tcttcccgct agcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaacctgtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgacagt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaggaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgg gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaact cgagataact     1440

tcgtatagca tacattatac gaagttatct gagcctcctc catccactgt ctccaacatg     1500

gcgaccgttg ctgttctggt tgtccttgga gctgcaatag tcactggagc tgtggtggct     1560

tttgtgatga agatgagaag gagaaacaca ggtggaaaag gaggggacta tgctctggct     1620

ccaggctccc agacctctga tctgtctctc ccagattgta aagtgatggt tcatgaccct     1680

cattctctag cgtgaagatc ttgaataact tcgtatagca tacattatac gaagttattg     1740

gcctaggcgc gccgcaggtc gcggccgcga ctctagagga tctttgtgaa ggaaccttac     1800

ttctgtggtg tgacataatt ggacaaacta cctacagaga tttaaagctc taaggtaaat     1860

ataaaatttt taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag     1920

attccaacct atggaactga                                                 1940


<210>  20
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn His Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Ile Asn Glu Asp Gly Ser Glu Lys Tyr Tyr Val 
65                  70                  75                  80  


Gly Ser Val Lys Val Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile 
        115                 120                 125             


His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Ile Thr 
465                 470                 475                 480 


Ser Tyr Ser Ile His Tyr Thr Lys Leu Ser Glu Pro Pro Pro Ser Thr 
                485                 490                 495     


Val Ser Asn Met Ala Thr Val Ala Val Leu Val Val Leu Gly Ala Ala 
            500                 505                 510         


Ile Val Thr Gly Ala Val Val Ala Phe Val Met Lys Met Arg Arg Arg 
        515                 520                 525             


Asn Thr Gly Gly Lys Gly Gly Asp Tyr Ala Leu Ala Pro Gly Ser Gln 
    530                 535                 540                 


Thr Ser Asp Leu Ser Leu Pro Asp Cys Lys Val Met Val His Asp Pro 
545                 550                 555                 560 


His Ser Leu Ala 
                


<210>  21
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn His Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Ile Asn Glu Asp Gly Ser Glu Lys Tyr Tyr Val 
65                  70                  75                  80  


Gly Ser Val Lys Val Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile 
        115                 120                 125             


His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Asp Ser Asn Leu Trp Asn 
465                 470                 475                 480 


<210>  22
<211>  1943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
atggaattgg ggctgagctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagttgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagtaac cattggatga actgggtccg ccagactcca      180

gggaaagggc tggagtgggt ggccgccata aacgaagatg gaagtgagaa atactatgtg      240

ggctctgtga aggtccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagt cgaggacacg gctgtgtatt actgtgtgag agattactat      360

gatatactta cagattacta catacactac tggtacttcg atctctgggg ccgtggcacc      420

ctggtcactg tctcctcagc ctccaccaag ggcccatcgg tcttcccgct agcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaacctgtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgacagt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaggaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgg gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaact cgagataact     1440

tcgtatagca tacattatac gaagttatct gagcctcctc catccactgt ctccaacatg     1500

gcgaccgttg ctgttctggt tgtccttgga gctgcaatag tcactggagc tgtggtggct     1560

tttgtgatga agatgagaag gagaaacaca ggtggaaaag gaggggacta tgctctggct     1620

ccaggctccc agacctctga tctgtctctc ccagattgta aagtgatggt tcatgaccct     1680

cattctctag cgtgaagatc ttgaataact tcgtatagca tacattatac gaagttattg     1740

gcctaggcgc gccgcaggtc gcggccgcga ctctagagga tctttgtgaa ggaaccttac     1800

ttctgtggtg tgacataatt ggacaaacta cctacagaga tttaaagctc taaggtaaat     1860

ataaaatttt taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag     1920

attccaacct atggaactga tga                                             1943


<210>  23
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn His Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Ile Asn Glu Asp Gly Ser Glu Lys Tyr Tyr Val 
65                  70                  75                  80  


Gly Ser Val Lys Val Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile 
        115                 120                 125             


His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Ile Thr 
465                 470                 475                 480 


Ser Tyr Ser Ile His Tyr Thr Lys Leu Ser Glu Pro Pro Pro Ser Thr 
                485                 490                 495     


Val Ser Asn Met Ala Thr Val Ala Val Leu Val Val Leu Gly Ala Ala 
            500                 505                 510         


Ile Val Thr Gly Ala Val Val Ala Phe Val Met Lys Met Arg Arg Arg 
        515                 520                 525             


Asn Thr Gly Gly Lys Gly Gly Asp Tyr Ala Leu Ala Pro Gly Ser Gln 
    530                 535                 540                 


Thr Ser Asp Leu Ser Leu Pro Asp Cys Lys Val Met Val His Asp Pro 
545                 550                 555                 560 


His Ser Leu Ala 
                


<210>  24
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn His Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Ile Asn Glu Asp Gly Ser Glu Lys Tyr Tyr Val 
65                  70                  75                  80  


Gly Ser Val Lys Val Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile 
        115                 120                 125             


His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Asp Ser Asn Leu Trp Asn 
465                 470                 475                 480 


<210>  25
<211>  3044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
atggaattgg ggctgagctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagttgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagtaac cattggatga actgggtccg ccagactcca      180

gggaaagggc tggagtgggt ggccgccata aacgaagatg gaagtgagaa atactatgtg      240

ggctctgtga aggtccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagt cgaggacacg gctgtgtatt actgtgcaag agattactat      360

gatatactta cagattacta catacactac tggtacttcg atctctgggg ccgtggcacc      420

ctggtcactg tctcctcagc ctccaccaag ggcccatcgg tcttcccgct agcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccagtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaacaggtaa atctcgagat aacttcgtat      780

agcatacatt atacgaagtt attgggcggt agtggaggtt ctggtgtgag caagggcgag      840

gagaccacaa tgggcgtaat caagcccgac atgaagatca agctgaagat ggagggcaac      900

gtgaatggcc acgccttcgt gatcgagggc gagggcgagg gcaagcccta cgacggcacc      960

aacaccatca acctggaggt gaaggaggga gcccccctgc ccttctccta cgacattctg     1020

accaccgcgt tcagttacgg caacagggcc ttcaccaagt accccgacga catccccaac     1080

tacttcaagc agtccttccc cgagggctac tcttgggagc gcaccatgac cttcgaggac     1140

aagggcatcg tgaaggtgaa gtccgacatc tccatggagg aggactcctt catctacgag     1200

atacacctca agggcgagaa cttccccccc aacggccccg tgatgcagaa ggagaccacc     1260

ggctgggacg cctccaccga gaggatgtac gtgcgcgacg gcgtgctgaa gggcgacgtc     1320

aagatgaagc tgctgctgga gggcggcggc caccaccgcg ttgacttcaa gaccatctac     1380

agggccaaga aggcggtgaa gctgcccgac tatcactttg tggaccaccg catcgagatc     1440

ctgaaccacg acaaggacta caacaaggtg accgtttacg agatcgccgt ggcccgcaac     1500

tccaccgacg gcatggacga gctgtacaag tgatggccta ggcgcgccgc aggtcgcggc     1560

cgcgactcta gaggatcttt gtgaaggaac cttacttctg tggtgtgaca taattggaca     1620

aactacctac agagatttaa agctctaagg taaatataaa atttttaagt gtataatgtg     1680

ttaaactact gattctaatt gtttgtgtat tttaggattc caacggcggc ggtgcttcag     1740

gagctggtag tggcagtgga ggtgcatctg gtgtaagcaa gggtgaggaa aacaacatgg     1800

caattataaa ggagtttatg aggttcaagg tacacatgga aggttctgta aatgggcatg     1860

aatttgaaat agaaggcgaa ggcgagggta gaccttacga ggcatttcaa acagctaagc     1920

tgaaggttac taaaggcggg cctctgcctt ttgcctggga tatactttca ccacagttta     1980

tgtatggcag taaagtgtat ataaagcatc cagctgatat acccgactac tttaagttga     2040

gctttccgga gggctttaag tgggagagag ttatgaactt cgaggacggc ggtataatac     2100

atgttaacca agacagcagc ctacaagatg gtgtgttcat ttacaaggtt aagctgaggg     2160

gtaccaactt ccctagcgac ggccctgtaa tgcagaagaa aacaatgggt tgggaagcca     2220

gcagcgaacg gatgtaccca gaggacggtg ctttaaaatc tgaaattaag aagcggttaa     2280

agctgaaaga tggagggcac tatgcaagtg aagtaaaaac tacttacaaa gcaaagaaac     2340

ccgtacaact acccggtgca tacattgttg atatcaaact tgacattacc agccataacg     2400

aggactacac aatagtagaa cagtatgaac gtgctgaggg caggcacagt actggtggta     2460

tggacgaact gtataagtac actgatatcg aaatgaaccg cctgggtaag tgatgaatgg     2520

gagcagtggt ggaatgcctt taatgaggaa aacctgtttt gctcagaaga aatgccatct     2580

agtgatgatg aggctactgc tgactctcaa cattctactc ctccaaaaaa gaagagaaag     2640

gtagaagacc ccaaggactt tccttcagaa ttgctaagtt ttttgagtca tgctgtgttt     2700

agtaatagaa ctcttgcttg ctttgctatt tacaccacaa aggaaaaagc tgcactgcta     2760

tacaagaaaa ttatggaaaa atatttgatg tatagtgcct tgactagaga tcataatcag     2820

ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa     2880

cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg     2940

ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc     3000

tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtct                      3044


<210>  26
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn His Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Ile Asn Glu Asp Gly Ser Glu Lys Tyr Tyr Val 
65                  70                  75                  80  


Gly Ser Val Lys Val Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile 
        115                 120                 125             


His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Gln Val Asn Leu Glu 
                245                 250                 255     


Ile Thr Ser Tyr Ser Ile His Tyr Thr Lys Leu Leu Gly Gly Ser Gly 
            260                 265                 270         


Gly Ser Gly Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys 
        275                 280                 285             


Pro Asp Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His 
    290                 295                 300                 


Ala Phe Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr 
305                 310                 315                 320 


Asn Thr Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser 
                325                 330                 335     


Tyr Asp Ile Leu Thr Thr Ala Phe Ser Tyr Gly Asn Arg Ala Phe Thr 
            340                 345                 350         


Lys Tyr Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu 
        355                 360                 365             


Gly Tyr Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val 
    370                 375                 380                 


Lys Val Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu 
385                 390                 395                 400 


Ile His Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln 
                405                 410                 415     


Lys Glu Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg 
            420                 425                 430         


Asp Gly Val Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Glu Gly 
        435                 440                 445             


Gly Gly His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys 
    450                 455                 460                 


Ala Val Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile 
465                 470                 475                 480 


Leu Asn His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ile Ala 
                485                 490                 495     


Val Ala Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys 
            500                 505                 510 


<210>  27
<211>  2085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
atggaattgg ggctgagctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagttgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagtaac cattggatga actgggtccg ccagactcca      180

gggaaagggc tggagtgggt ggccgccata aacgaagatg gaagtgagaa atactatgtg      240

ggctctgtga aggtccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagt cgaggacacg gctgtgtatt actgtgcaag agattactat      360

gatatactta cagattacta catacactac tggtacttcg atctctgggg ccgtggcacc      420

ctggtcactg tctcctcagc ctccaccaag ggcccatcgg tcttcccgct agcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccagtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaacaggatt ccaacggcgg cggtgcttca      780

ggagctggta gtggcagtgg aggtgcatct ggtgtaagca agggtgagga aaacaacatg      840

gcaattataa aggagtttat gaggttcaag gtacacatgg aaggttctgt aaatgggcat      900

gaatttgaaa tagaaggcga aggcgagggt agaccttacg aggcatttca aacagctaag      960

ctgaaggtta ctaaaggcgg gcctctgcct tttgcctggg atatactttc accacagttt     1020

atgtatggca gtaaagtgta tataaagcat ccagctgata tacccgacta ctttaagttg     1080

agctttccgg agggctttaa gtgggagaga gttatgaact tcgaggacgg cggtataata     1140

catgttaacc aagacagcag cctacaagat ggtgtgttca tttacaaggt taagctgagg     1200

ggtaccaact tccctagcga cggccctgta atgcagaaga aaacaatggg ttgggaagcc     1260

agcagcgaac ggatgtaccc agaggacggt gctttaaaat ctgaaattaa gaagcggtta     1320

aagctgaaag atggagggca ctatgcaagt gaagtaaaaa ctacttacaa agcaaagaaa     1380

cccgtacaac tacccggtgc atacattgtt gatatcaaac ttgacattac cagccataac     1440

gaggactaca caatagtaga acagtatgaa cgtgctgagg gcaggcacag tactggtggt     1500

atggacgaac tgtataagta cactgatatc gaaatgaacc gcctgggtaa gtgatgaatg     1560

ggagcagtgg tggaatgcct ttaatgagga aaacctgttt tgctcagaag aaatgccatc     1620

tagtgatgat gaggctactg ctgactctca acattctact cctccaaaaa agaagagaaa     1680

ggtagaagac cccaaggact ttccttcaga attgctaagt tttttgagtc atgctgtgtt     1740

tagtaataga actcttgctt gctttgctat ttacaccaca aaggaaaaag ctgcactgct     1800

atacaagaaa attatggaaa aatatttgat gtatagtgcc ttgactagag atcataatca     1860

gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga     1920

acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg     1980

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     2040

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtct                     2085


<210>  28
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn His Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Ile Asn Glu Asp Gly Ser Glu Lys Tyr Tyr Val 
65                  70                  75                  80  


Gly Ser Val Lys Val Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile 
        115                 120                 125             


His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Gln Asp Ser Asn Gly 
                245                 250                 255     


Gly Gly Ala Ser Gly Ala Gly Ser Gly Ser Gly Gly Ala Ser Gly Val 
            260                 265                 270         


Ser Lys Gly Glu Glu Asn Asn Met Ala Ile Ile Lys Glu Phe Met Arg 
        275                 280                 285             


Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile 
    290                 295                 300                 


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Ala Phe Gln Thr Ala Lys 
305                 310                 315                 320 


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
                325                 330                 335     


Ser Pro Gln Phe Met Tyr Gly Ser Lys Val Tyr Ile Lys His Pro Ala 
            340                 345                 350         


Asp Ile Pro Asp Tyr Phe Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
        355                 360                 365             


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Ile Ile His Val Asn Gln 
    370                 375                 380                 


Asp Ser Ser Leu Gln Asp Gly Val Phe Ile Tyr Lys Val Lys Leu Arg 
385                 390                 395                 400 


Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met 
                405                 410                 415     


Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu 
            420                 425                 430         


Lys Ser Glu Ile Lys Lys Arg Leu Lys Leu Lys Asp Gly Gly His Tyr 
        435                 440                 445             


Ala Ser Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu 
    450                 455                 460                 


Pro Gly Ala Tyr Ile Val Asp Ile Lys Leu Asp Ile Thr Ser His Asn 
465                 470                 475                 480 


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His 
                485                 490                 495     


Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Tyr Thr Asp Ile Glu Met 
            500                 505                 510         


Asn Arg Leu Gly Lys 
        515         


<210>  29
<211>  2588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
atgagggcct ggatcttctt tctcctttgc ctggccggga gggccttggc agaggttcag       60

ctggtggagt ctggcggtgg cctggtgcag cccgggggct ctctccgttt gtcctgtgca      120

gcttctggct tcaacattaa agacacctat atccactggg tgcgtcaggc tccgggtaag      180

ggcctggagt gggttgcaag gatttatcct acgaatggtt atactcgtta tgccgatagc      240

gtcaagggcc gtttcactat aagcgcagac acttcgaaaa acacagccta cctccagatg      300

aacagcctgc gtgctgagga cactgccgtc tattattgta gcagatgggg tggggacggc      360

ttctatgcta tggactactg gggtcaaggt acactagtca ccgtcagcag cgcttccacc      420

aagggcccat ccgtcttccc gctagcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccag tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaacagg taaatctcga gataacttcg tatagcatac attatacgaa gttatctgag      780

cctcctccat ccactgtctc caacatggcg accgttgctg ttctggttgt ccttggagct      840

gcaatagtca ctggagctgt ggtggctttt gtgatgaaga tgagaaggag aaacacagga      900

ggaaaaggag gggactatgc tctggctcca ggctcccaga cctctgatct gtctctccca      960

gattgtaaag tgatggttca tgaccctcat tctctagcgt gaagatcttg atggcctagg     1020

cgcgccgcag gtcgcggccg cgactctaga ggatctttgt gaaggaacct tacttctgtg     1080

gtgtgacata attggacaaa ctacctacag agatttaaag ctctaaggta aatataaaat     1140

ttttaagtgt ataatgtgtt aaactactga ttctaattgt ttgtgtattt taggattcca     1200

acggcggcgg tgcttcagga gctggtagtg gcagtggagg tgcatctggt gtcacatcaa     1260

tcacattaga tctagtaaat ccgactgccg gtcaatactc atctttcgtg gataaaatcc     1320

gaaacaacgt aaaggatcca aacctgaaat acggtggtac cgacatagcc gtgataggcc     1380

caccttctaa agataaattc cttagaatta atttccaaag ttcccgagga acggtctcac     1440

ttggcctaaa acgcgataac ttgtacgtgg tcgcgtatct tgcaatggat aacacgaatg     1500

ttaatcgggc atattacttc aaatcagaaa ttacttccgc cgagttaacc gcccttttcc     1560

cagaggccac aactgcaaat cagaaagctt tagaatacac agaagattat cagtcgatcg     1620

aaaagaatgc ccagataaca cagggagata aaagtagaaa agaactcggg ttggggatcg     1680

acttactttt gacgttcatg gaagcagtga acaagaaggc acgtgtggtt aaaaacgaag     1740

ctaggtttct gcttatcgct attcaaatga cagctgaggt agcacgattt aggtacattc     1800

aaaacttggt aactaagaac ttccccaaca agttcgactc ggataacaag gtgattcaat     1860

ttgaagtcag ctggcgtaag atttctacgg caatatacgg ggatgccaaa aacggcgtgt     1920

ttaataaaga ttatgatttc gggtttggaa aagtgaggca ggtgaaggac ttgcaaatgg     1980

gactccttat gtatttgggc aaaccaaagt cgtcaaacga ggcgaattct actgcttacg     2040

ccactacggt cctctgatga atgggagcag tggtggaatg cctttaatga ggaaaacctg     2100

ttttgctcag aagaaatgcc atctagtgat gatgaggcta ctgctgactc tcaacattct     2160

actcctccaa aaaagaagag aaaggtagaa gaccccaagg actttccttc agaattgcta     2220

agttttttga gtcatgctgt gtttagtaat agaactcttg cttgctttgc tatttacacc     2280

acaaaggaaa aagctgcact gctatacaag aaaattatgg aaaaatattt gatgtatagt     2340

gccttgacta gagatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa     2400

aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa     2460

cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa     2520

taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta     2580

tcatgtct                                                              2588


<210>  30
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
        35                  40                  45              


Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Gln Val Asn Leu Glu Ile Thr Ser Tyr Ser Ile His Tyr Thr 
                245                 250                 255     


Lys Leu Ser Glu Pro Pro Pro Ser Thr Val Ser Asn Met Ala Thr Val 
            260                 265                 270         


Ala Val Leu Val Val Leu Gly Ala Ala Ile Val Thr Gly Ala Val Val 
        275                 280                 285             


Ala Phe Val Met Lys Met Arg Arg Arg Asn Thr Gly Gly Lys Gly Gly 
    290                 295                 300                 


Asp Tyr Ala Leu Ala Pro Gly Ser Gln Thr Ser Asp Leu Ser Leu Pro 
305                 310                 315                 320 


Asp Cys Lys Val Met Val His Asp Pro His Ser Leu Ala 
                325                 330             


<210>  31
<211>  2124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
atgagggcct ggatcttctt tctcctttgc ctggccggga gggccttggc agaggttcag       60

ctggtggagt ctggcggtgg cctggtgcag cccgggggct ctctccgttt gtcctgtgca      120

gcttctggct tcaacattaa agacacctat atccactggg tgcgtcaggc tccgggtaag      180

ggcctggagt gggttgcaag gatttatcct acgaatggtt atactcgtta tgccgatagc      240

gtcaagggcc gtttcactat aagcgcagac acttcgaaaa acacagccta cctccagatg      300

aacagcctgc gtgctgagga cactgccgtc tattattgta gcagatgggg tggggacggc      360

ttctatgcta tggactactg gggtcaaggt acactagtca ccgtcagcag cgcttccacc      420

aagggcccat ccgtcttccc gctagcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccag tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaacagg attccaacgg cggcggtgct tcaggagctg gtagtggcag tggaggtgca      780

tctggtgtca catcaatcac attagatcta gtaaatccga ctgccggtca atactcatct      840

ttcgtggata aaatccgaaa caacgtaaag gatccaaacc tgaaatacgg tggtaccgac      900

atagccgtga taggcccacc ttctaaagat aaattcctta gaattaattt ccaaagttcc      960

cgaggaacgg tctcacttgg cctaaaacgc gataacttgt acgtggtcgc gtatcttgca     1020

atggataaca cgaatgttaa tcgggcatat tacttcaaat cagaaattac ttccgccgag     1080

ttaaccgccc ttttcccaga ggccacaact gcaaatcaga aagctttaga atacacagaa     1140

gattatcagt cgatcgaaaa gaatgcccag ataacacagg gagataaaag tagaaaagaa     1200

ctcgggttgg ggatcgactt acttttgacg ttcatggaag cagtgaacaa gaaggcacgt     1260

gtggttaaaa acgaagctag gtttctgctt atcgctattc aaatgacagc tgaggtagca     1320

cgatttaggt acattcaaaa cttggtaact aagaacttcc ccaacaagtt cgactcggat     1380

aacaaggtga ttcaatttga agtcagctgg cgtaagattt ctacggcaat atacggggat     1440

gccaaaaacg gcgtgtttaa taaagattat gatttcgggt ttggaaaagt gaggcaggtg     1500

aaggacttgc aaatgggact ccttatgtat ttgggcaaac caaagtcgtc aaacgaggcg     1560

aattctactg cttacgccac tacggtcctc tgatgaatgg gagcagtggt ggaatgcctt     1620

taatgaggaa aacctgtttt gctcagaaga aatgccatct agtgatgatg aggctactgc     1680

tgactctcaa cattctactc ctccaaaaaa gaagagaaag gtagaagacc ccaaggactt     1740

tccttcagaa ttgctaagtt ttttgagtca tgctgtgttt agtaatagaa ctcttgcttg     1800

ctttgctatt tacaccacaa aggaaaaagc tgcactgcta tacaagaaaa ttatggaaaa     1860

atatttgatg tatagtgcct tgactagaga tcataatcag ccataccaca tttgtagagg     1920

ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg     1980

caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca     2040

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac     2100

tcatcaatgt atcttatcat gtct                                            2124


<210>  32
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
        35                  40                  45              


Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Gln Asp Ser Asn Gly Gly Gly Ala Ser Gly Ala Gly Ser Gly 
                245                 250                 255     


Ser Gly Gly Ala Ser Gly Val Thr Ser Ile Thr Leu Asp Leu Val Asn 
            260                 265                 270         


Pro Thr Ala Gly Gln Tyr Ser Ser Phe Val Asp Lys Ile Arg Asn Asn 
        275                 280                 285             


Val Lys Asp Pro Asn Leu Lys Tyr Gly Gly Thr Asp Ile Ala Val Ile 
    290                 295                 300                 


Gly Pro Pro Ser Lys Asp Lys Phe Leu Arg Ile Asn Phe Gln Ser Ser 
305                 310                 315                 320 


Arg Gly Thr Val Ser Leu Gly Leu Lys Arg Asp Asn Leu Tyr Val Val 
                325                 330                 335     


Ala Tyr Leu Ala Met Asp Asn Thr Asn Val Asn Arg Ala Tyr Tyr Phe 
            340                 345                 350         


Lys Ser Glu Ile Thr Ser Ala Glu Leu Thr Ala Leu Phe Pro Glu Ala 
        355                 360                 365             


Thr Thr Ala Asn Gln Lys Ala Leu Glu Tyr Thr Glu Asp Tyr Gln Ser 
    370                 375                 380                 


Ile Glu Lys Asn Ala Gln Ile Thr Gln Gly Asp Lys Ser Arg Lys Glu 
385                 390                 395                 400 


Leu Gly Leu Gly Ile Asp Leu Leu Leu Thr Phe Met Glu Ala Val Asn 
                405                 410                 415     


Lys Lys Ala Arg Val Val Lys Asn Glu Ala Arg Phe Leu Leu Ile Ala 
            420                 425                 430         


Ile Gln Met Thr Ala Glu Val Ala Arg Phe Arg Tyr Ile Gln Asn Leu 
        435                 440                 445             


Val Thr Lys Asn Phe Pro Asn Lys Phe Asp Ser Asp Asn Lys Val Ile 
    450                 455                 460                 


Gln Phe Glu Val Ser Trp Arg Lys Ile Ser Thr Ala Ile Tyr Gly Asp 
465                 470                 475                 480 


Ala Lys Asn Gly Val Phe Asn Lys Asp Tyr Asp Phe Gly Phe Gly Lys 
                485                 490                 495     


Val Arg Gln Val Lys Asp Leu Gln Met Gly Leu Leu Met Tyr Leu Gly 
            500                 505                 510         


Lys Pro Lys Ser Ser Asn Glu Ala Asn Ser Thr Ala Tyr Ala Thr Thr 
        515                 520                 525             


Val Leu 
    530 


<210>  33
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala His His His His His His Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Ala Gly Gly Ala Ser Gly Ala Gly Ser Gly Ser Gly Gly Ala Ser 
        35                  40                  45              


Gly Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp 
    50                  55                  60                  


Lys Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg 
65                  70                  75                  80  


Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser 
                85                  90                  95      


Thr Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro 
            100                 105                 110         


Ser Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala 
        115                 120                 125             


Asp Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu 
    130                 135                 140                 


Ile Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg 
145                 150                 155                 160 


Leu Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile 
                165                 170                 175     


Val His His Val Ala 
            180     


