                         SEQUENCE LISTING

<110>  Byron, Sara
       Pollock, Pamela
 
<120>  METHODS OF DETERMINING SUSCEPTIBILITY OF TUMORS TO TYROSINE 
       KINASE INHIBITORS

<130>  063608-

<150>  US 61/313,762
<151>  2010-03-14

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  4647
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  fibroblast growth factor receptor 2 isoform 2 precursor

<400>  1
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg       60

ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta      120

cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg      180

ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg      240

tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc      300

cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt      360

ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg      420

ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag      480

gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc      540

gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa      600

cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg      660

gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct      720

tcagtttagt tgaggatacc acattagagc cagaagagcc accaaccaaa taccaaatct      780

ctcaaccaga agtgtacgtg gctgcgccag gggagtcgct agaggtgcgc tgcctgttga      840

aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc aacaatagga      900

cagtgcttat tggggagtac ttgcagataa agggcgccac gcctagagac tccggcctct      960

atgcttgtac tgccagtagg actgtagaca gtgaaacttg gtacttcatg gtgaatgtca     1020

cagatgccat ctcatccgga gatgatgagg atgacaccga tggtgcggaa gattttgtca     1080

gtgagaacag taacaacaag agagcaccat actggaccaa cacagaaaag atggaaaagc     1140

ggctccatgc tgtgcctgcg gccaacactg tcaagtttcg ctgcccagcc ggggggaacc     1200

caatgccaac catgcggtgg ctgaaaaacg ggaaggagtt taagcaggag catcgcattg     1260

gaggctacaa ggtacgaaac cagcactgga gcctcattat ggaaagtgtg gtcccatctg     1320

acaagggaaa ttatacctgt gtagtggaga atgaatacgg gtccatcaat cacacgtacc     1380

acctggatgt tgtggagcga tcgcctcacc ggcccatcct ccaagccgga ctgccggcaa     1440

atgcctccac agtggtcgga ggagacgtag agtttgtctg caaggtttac agtgatgccc     1500

agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac gggcccgacg     1560

ggctgcccta cctcaaggtt ctcaagcact cggggataaa tagttccaat gcagaagtgc     1620

tggctctgtt caatgtgacc gaggcggatg ctggggaata tatatgtaag gtctccaatt     1680

atatagggca ggccaaccag tctgcctggc tcactgtcct gccaaaacag caagcgcctg     1740

gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt tactgcatag     1800

gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg aagaacacga     1860

ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa cgtatccccc     1920

tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc aacaccccgc     1980

tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg gcaggggtct     2040

ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag ctgacactgg     2100

gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca gtgggaattg     2160

acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa gatgatgcca     2220

cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg attgggaaac     2280

acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc tatgtcatag     2340

ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg ccacccggga     2400

tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc aaggacttgg     2460

tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa aaatgtattc     2520

atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg aaaatagcag     2580

actttggact cgccagagat atcaacaata tagactatta caaaaagacc accaatgggc     2640

ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac actcatcaga     2700

gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg ggctcgccct     2760

acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac agaatggata     2820

agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg catgcagtgc     2880

cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt ctcactctca     2940

caaccaatga ggaatacttg gacctcagcc aacctctcga acagtattca cctagttacc     3000

ctgacacaag aagttcttgt tcttcaggag atgattctgt tttttctcca gaccccatgc     3060

cttacgaacc atgccttcct cagtatccac acataaacgg cagtgttaaa acatgaatga     3120

ctgtgtctgc ctgtccccaa acaggacagc actgggaacc tagctacact gagcagggag     3180

accatgcctc ccagagcttg ttgtctccac ttgtatatat ggatcagagg agtaaataat     3240

tggaaaagta atcagcatat gtgtaaagat ttatacagtt gaaaacttgt aatcttcccc     3300

aggaggagaa gaaggtttct ggagcagtgg actgccacaa gccaccatgt aacccctctc     3360

acctgccgtg cgtactggct gtggaccagt aggactcaag gtggacgtgc gttctgcctt     3420

ccttgttaat tttgtaataa ttggagaaga tttatgtcag cacacactta cagagcacaa     3480

atgcagtata taggtgctgg atgtatgtaa atatattcaa attatgtata aatatatatt     3540

atatatttac aaggagttat tttttgtatt gattttaaat ggatgtccca atgcacctag     3600

aaaattggtc tctctttttt taatagctat ttgctaaatg ctgttcttac acataatttc     3660

ttaattttca ccgagcagag gtggaaaaat acttttgctt tcagggaaaa tggtataacg     3720

ttaatttatt aataaattgg taatatacaa aacaattaat catttatagt tttttttgta     3780

atttaagtgg catttctatg caggcagcac agcagactag ttaatctatt gcttggactt     3840

aactagttat cagatccttt gaaaagagaa tatttacaat atatgactaa tttggggaaa     3900

atgaagtttt gatttatttg tgtttaaatg ctgctgtcag acgattgttc ttagacctcc     3960

taaatgcccc atattaaaag aactcattca taggaaggtg tttcattttg gtgtgcaacc     4020

ctgtcattac gtcaacgcaa cgtctaactg gacttcccaa gataaatggt accagcgtcc     4080

tcttaaaaga tgccttaatc cattccttga ggacagacct tagttgaaat gatagcagaa     4140

tgtgcttctc tctggcagct ggccttctgc ttctgagttg cacattaatc agattagcct     4200

gtattctctt cagtgaattt tgataatggc ttccagactc tttggcgttg gagacgcctg     4260

ttaggatctt caagtcccat catagaaaat tgaaacacag agttgttctg ctgatagttt     4320

tggggatacg tccatctttt taagggattg ctttcatcta attctggcag gacctcacca     4380

aaagatccag cctcatacct acatcagaca aaatatcgcc gttgttcctt ctgtactaaa     4440

gtattgtgtt ttgctttgga aacacccact cactttgcaa tagccgtgca agatgaatgc     4500

agattacact gatcttatgt gttacaaaat tggagaaagt atttaataaa acctgttaat     4560

ttttatactg acaataaaaa tgtttctaca gatattaatg ttaacaagac aaaataaatg     4620

tcacgcaact taaaaaaaaa aaaaaaa                                         4647


<210>  2
<211>  822
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  fibroblast growth factor receptor 2 isoform 2 precursor

<400>  2

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr 
    770                 775                 780                 


Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser 
785                 790                 795                 800 


Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile 
                805                 810                 815     


Asn Gly Ser Val Lys Thr 
            820         


