                         SEQUENCE LISTING

<110>  immatics Biotechnologies GmbH
 
<120>  Methods for the diagnosis and treatment of cancer based on AVL9

<130>  I32039PCT

<150>  GB 1004575.5
<151>  2010-03-19

<150>  US 61/315,704
<151>  2010-03-19

<150>  GB 1004551.6
<151>  2010-03-19

<150>  US 61/315,715
<151>  2010-03-19

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Tyr Ile Ser Pro Val Asn Lys Leu 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

His Leu Ser Asp Ala Ile Val Glu Val 
1               5                   


<210>  3
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Pro Phe Leu Ala Leu Pro Asp Gly Ala His Asn Tyr 
1               5                   10              


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Tyr Gly Leu Leu Gln Ala Lys Leu 
1               5                   


<210>  5
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Ile Ser Pro Val Asn Lys Leu 
1               5               


<210>  6
<211>  2353
<212>  DNA
<213>  Homo sapiens

<400>  6
gctttgcctc caccgatctc cctgtggggc cctcatgtgc tgtgctcgct gacacccgaa       60

gtccgcggct ttccgcacac ggtggggtcg tcagacccgc tgcccttggc ggtcgaagtc      120

gtcgtgcggg cccgcggcgg ccgcccatgg agaaggccag gagaggcggg gatggcgtcc      180

cccgggggcc cgtactgcac atcgtggtgg tcggatttca ccacaagaag ggctgccagg      240

ttgaattctc ttacccgccc ctgattccag gagatggaca tgacagccac actttacctg      300

aagaatggaa gtatttgccc ttccttgcct taccagatgg cgcacacaac taccaggaag      360

atactgtgtt ttttcacttg ccacccagaa atggaaatgg agccacagta tttggtatct      420

cttgctatcg acaaattgaa gccaaggcac tgaaagtaag gcaagcagat atcaccagag      480

agactgttca gaaaagtgtc tgtgttctaa gcaagctgcc tctgtatggt ttacttcaag      540

caaaacttca actcattaca catgcatatt ttgaagagaa ggatttttcc caaatttcta      600

ttctaaagga gctttatgaa catatgaata gttccttggg aggtgcttca ttagaaggat      660

cccaagtata tcttggtctg tcacctcgag atcttgtcct tcattttcga cacaaggtct      720

taatcctatt taagctaatt cttcttgaaa aaaaggttct tttttatatt tctccagtga      780

ataaattggt gggtgcactg atgactgtgt tatccctttt tccaggcatg attgaacatg      840

gtctcagtga ctgttctcag tatagacccc ggaaaagtat gtctgaagat ggtgggcttc      900

aggaaagtaa cccatgtgca gatgattttg tttctgcatc cactgctgat gtttcacata      960

ccaacttggg aactatcagg aaagtcatgg caggaaacca tggagaagat gctgccatga     1020

agactgagga gcctttgttc caagtggaag acagcagcaa agggcaggaa cccaatgata     1080

ccaatcaata tttgaaacct ccatctcgcc catctccaga ttcttcagaa agtgactggg     1140

aaactttgga tcctagtgtc ttagaggacc ccaacttgaa agaaagggaa cagctgggat     1200

cagaccagac aaatttgttt ccaaaggact ctgtcccctc agagagtctt ccaattactg     1260

tacaacctca agctaatacg ggacaggtag tcctgatacc agggctcatt tcgggtttgg     1320

aagaggatca gtatggcatg cccctggcca tcttcacaaa gggatatctg tgtttgcctt     1380

acatggcatt gcagcagcat catcttctct ccgatgtcac cgttcggggg tttgttgctg     1440

gagctactaa catccttttt cgacaacaga aacacctcag tgatgccatt gtggaagtag     1500

aagaagctct gatccagatc catgatccag aactcaggaa gctgcttaac ccaaccactg     1560

cagacctaag gttcgcagac tacctagtga ggcacgtgac tgagaatcgg gatgacgtct     1620

tcctagatgg cacgggctgg gagggaggtg acgaatggat ccgggcccag tttgcggtct     1680

acattcatgc cctgctggct gccacgctgc aattagacaa tgaaaagata ttatcggact     1740

atgggacaac ttttgttaca gcatggaaga atactcacaa ctacagggtg tggaacagca     1800

acaagcatcc agcacttgca gaaataaatc caaaccatcc atttcaaggc caatactcag     1860

tatcagacat gaagttaagg ttctcacatt ctgttcagaa tagtgaacgt ggcaaaaaaa     1920

ttggaaacgt catggtcaca actagccgga atgttgtaca aacaggaaaa gctgttggcc     1980

agtcagttgg aggagctttt tccagtgcaa agacagctat gtcttcatgg ctttccactt     2040

tcaccacttc cacctcccaa agtctcactg agccaccaga tgagaagcct tgagcaaggc     2100

gtcagaggct gctattgctt tctgaggttt aagtgtcccc tgtctgtctg ctgctcccag     2160

gctgttacta gccacagatc cacagcaggg gaccatatgt cgaactgttt acatggatgt     2220

tgctctaagt gaatgtttcg ggatgccgaa atgatgaaat cacagccata gcagggatgg     2280

ctttccaggt tggggtttca attgactact tttatttcag tctgagcctg attaaaacat     2340

acagtgaacc ttc                                                        2353


<210>  7
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Lys Ala Arg Arg Gly Gly Asp Gly Val Pro Arg Gly Pro Val 
1               5                   10                  15      


Leu His Ile Val Val Val Gly Phe His His Lys Lys Gly Cys Gln Val 
            20                  25                  30          


Glu Phe Ser Tyr Pro Pro Leu Ile Pro Gly Asp Gly His Asp Ser His 
        35                  40                  45              


Thr Leu Pro Glu Glu Trp Lys Tyr Leu Pro Phe Leu Ala Leu Pro Asp 
    50                  55                  60                  


Gly Ala His Asn Tyr Gln Glu Asp Thr Val Phe Phe His Leu Pro Pro 
65                  70                  75                  80  


Arg Asn Gly Asn Gly Ala Thr Val Phe Gly Ile Ser Cys Tyr Arg Gln 
                85                  90                  95      


Ile Glu Ala Lys Ala Leu Lys Val Arg Gln Ala Asp Ile Thr Arg Glu 
            100                 105                 110         


Thr Val Gln Lys Ser Val Cys Val Leu Ser Lys Leu Pro Leu Tyr Gly 
        115                 120                 125             


Leu Leu Gln Ala Lys Leu Gln Leu Ile Thr His Ala Tyr Phe Glu Glu 
    130                 135                 140                 


Lys Asp Phe Ser Gln Ile Ser Ile Leu Lys Glu Leu Tyr Glu His Met 
145                 150                 155                 160 


Asn Ser Ser Leu Gly Gly Ala Ser Leu Glu Gly Ser Gln Val Tyr Leu 
                165                 170                 175     


Gly Leu Ser Pro Arg Asp Leu Val Leu His Phe Arg His Lys Val Leu 
            180                 185                 190         


Ile Leu Phe Lys Leu Ile Leu Leu Glu Lys Lys Val Leu Phe Tyr Ile 
        195                 200                 205             


Ser Pro Val Asn Lys Leu Val Gly Ala Leu Met Thr Val Leu Ser Leu 
    210                 215                 220                 


Phe Pro Gly Met Ile Glu His Gly Leu Ser Asp Cys Ser Gln Tyr Arg 
225                 230                 235                 240 


Pro Arg Lys Ser Met Ser Glu Asp Gly Gly Leu Gln Glu Ser Asn Pro 
                245                 250                 255     


Cys Ala Asp Asp Phe Val Ser Ala Ser Thr Ala Asp Val Ser His Thr 
            260                 265                 270         


Asn Leu Gly Thr Ile Arg Lys Val Met Ala Gly Asn His Gly Glu Asp 
        275                 280                 285             


Ala Ala Met Lys Thr Glu Glu Pro Leu Phe Gln Val Glu Asp Ser Ser 
    290                 295                 300                 


Lys Gly Gln Glu Pro Asn Asp Thr Asn Gln Tyr Leu Lys Pro Pro Ser 
305                 310                 315                 320 


Arg Pro Ser Pro Asp Ser Ser Glu Ser Asp Trp Glu Thr Leu Asp Pro 
                325                 330                 335     


Ser Val Leu Glu Asp Pro Asn Leu Lys Glu Arg Glu Gln Leu Gly Ser 
            340                 345                 350         


Asp Gln Thr Asn Leu Phe Pro Lys Asp Ser Val Pro Ser Glu Ser Leu 
        355                 360                 365             


Pro Ile Thr Val Gln Pro Gln Ala Asn Thr Gly Gln Val Val Leu Ile 
    370                 375                 380                 


Pro Gly Leu Ile Ser Gly Leu Glu Glu Asp Gln Tyr Gly Met Pro Leu 
385                 390                 395                 400 


Ala Ile Phe Thr Lys Gly Tyr Leu Cys Leu Pro Tyr Met Ala Leu Gln 
                405                 410                 415     


Gln His His Leu Leu Ser Asp Val Thr Val Arg Gly Phe Val Ala Gly 
            420                 425                 430         


Ala Thr Asn Ile Leu Phe Arg Gln Gln Lys His Leu Ser Asp Ala Ile 
        435                 440                 445             


Val Glu Val Glu Glu Ala Leu Ile Gln Ile His Asp Pro Glu Leu Arg 
    450                 455                 460                 


Lys Leu Leu Asn Pro Thr Thr Ala Asp Leu Arg Phe Ala Asp Tyr Leu 
465                 470                 475                 480 


Val Arg His Val Thr Glu Asn Arg Asp Asp Val Phe Leu Asp Gly Thr 
                485                 490                 495     


Gly Trp Glu Gly Gly Asp Glu Trp Ile Arg Ala Gln Phe Ala Val Tyr 
            500                 505                 510         


Ile His Ala Leu Leu Ala Ala Thr Leu Gln Leu Asp Asn Glu Lys Ile 
        515                 520                 525             


Leu Ser Asp Tyr Gly Thr Thr Phe Val Thr Ala Trp Lys Asn Thr His 
    530                 535                 540                 


Asn Tyr Arg Val Trp Asn Ser Asn Lys His Pro Ala Leu Ala Glu Ile 
545                 550                 555                 560 


Asn Pro Asn His Pro Phe Gln Gly Gln Tyr Ser Val Ser Asp Met Lys 
                565                 570                 575     


Leu Arg Phe Ser His Ser Val Gln Asn Ser Glu Arg Gly Lys Lys Ile 
            580                 585                 590         


Gly Asn Val Met Val Thr Thr Ser Arg Asn Val Val Gln Thr Gly Lys 
        595                 600                 605             


Ala Val Gly Gln Ser Val Gly Gly Ala Phe Ser Ser Ala Lys Thr Ala 
    610                 615                 620                 


Met Ser Ser Trp Leu Ser Thr Phe Thr Thr Ser Thr Ser Gln Ser Leu 
625                 630                 635                 640 


Thr Glu Pro Pro Asp Glu Lys Pro 
                645             


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Tyr Gln Ile Leu Gln Gly Ile Val Phe 
1               5                   10  


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Tyr Asn Pro Leu Trp Leu Arg Ile 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Asn Tyr Leu Pro Phe Ile Met Glu Leu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Tyr Ile Asp Val Leu Pro Glu Phe 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Tyr Tyr Asn Ala Ala Gly Phe Asn Lys Leu 
1               5                   10  


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Asn Tyr Leu Leu Tyr Val Ser Asn Phe 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Tyr Leu Val Tyr Thr Asp Arg Leu 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

His Tyr Lys Pro Thr Pro Leu Tyr Phe 
1               5                   


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Trp Ser Asp Val Thr Pro Leu Thr Phe 
1               5                   10  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn 
1               5                   10                  15  


<210>  19
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Asp Pro Ser Thr Ile Glu Lys Leu Ala Lys Asn Lys Gln Lys Pro 
1               5                   10                  15      


<210>  20
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  20

Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys Leu Ala Arg 
1               5                   10                  15      


Asp 
    


<210>  21
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  21

Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro 
1               5                   10                  15      


Ser 
    


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asp 
1               5                   10                  15  


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Phe Thr Glu Leu Thr Leu Gly Glu Phe 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Met Leu Gly Glu Phe Leu Lys Leu 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Pro Asp Leu Ala Gln Cys Phe Tyr 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Val Tyr Gly Ile Arg Leu Glu His Phe 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Thr Tyr Gly Asn Leu Leu Asp Tyr Leu 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Phe Leu Ser Gly Ile Ile Asn Phe 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Val Tyr Thr Thr Ser Tyr Gln Gln Ile 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Asn Tyr Glu Glu Thr Phe Pro His Ile 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Tyr Leu Trp Ala Thr Val Thr Ile 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Val Tyr Phe Ser Lys Ser Glu Gln Leu 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Val Phe Ile Phe Lys Gly Asn Gln Phe 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Tyr Ala Ser Arg Phe Val Gln Leu 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  35

Lys Tyr Leu Thr Val Lys Asp Tyr Leu 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  36

Val Tyr Asn Pro Thr Pro Asn Ser Leu 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Tyr Leu Gln Ala Ala Asn Ala Leu 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  38

Phe Tyr Gln Pro Lys Ile Gln Gln Phe 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  39

Tyr Tyr Lys Asn Ile Gly Leu Gly Phe 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Tyr Ala Ile Ile Lys Glu Glu Leu 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Tyr Pro Glu Val Phe Glu Lys Phe 
1               5                   


<210>  42
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  42

Lys Tyr Asn Asp Thr Phe Trp Lys Glu Phe 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  43

Val Phe Asp Thr Ala Ile Ala His Leu Phe 
1               5                   10  


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Val Tyr Pro Asn Trp Ala Ile Gly Leu 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Val Tyr Lys Val Val Gly Asn Leu Leu 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Val Tyr Ile Glu Lys Asn Asp Lys Leu 
1               5                   


<210>  47
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  47

Ile Tyr Asn Gly Lys Leu Phe Asp Leu Leu 
1               5                   10  



