
                                SEQUENCE LISTING

<110> iCo Therapeutics Inc.
      Clement, John G.
     

<120> TREATING AND PREVENTING HEPATITIS C VIRUS
  INFECTION USING C-RAF KINASE ANTISENSE 
  OLIGONUCLEOTIDES
  

<130> 480231.409PC

<140> PCT                  
<141> 2011-03-07

<150> US 61/311,710
<151> 2010-03-08

<150> US 61/332,582
<151> 2010-05-07

<150> US 61/353,997
<151> 2010-06-11  

<160> 29

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 1
tgaaggtgag ctggagccat                                             20

<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 2
gctccattga tgcagcttaa                                             20

<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 3
ccctgtatgt gctccattga                                             20

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 4
ggtgcaaagt caactagaag                                             20

<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 5
attcttaaac ctgagggagc                                             20

<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 6
gatgcagctt aaacaattct                                             20

<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 7
cagcactgca aatggcttcc                                             20

<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 8
tcccgcctgt gacatgcatt                                             20

<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 9
gccgagtgcc ttgcctggaa                                             20

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 10
agagatgcag ctggagccat                                             20

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 11
aggtgaaggc ctggagccat                                             20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 12
gtctggcgct gcaccactct                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 13
ctgatttcca aaatcccatg                                             20

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 14
ctgggctgtt tggtgcctta                                             20

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 15
tcagggctgg actgcctgct                                             20

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 16
ggtgagggag cgggaggcgg                                             20

<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 17
cgctcctcct ccccgcggcg                                             20

<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 18
ttcggcggca gcttctcgcc                                             20

<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 19
gccgccccaa cgtcctgtcg                                             20

<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 20
tcctcctccc cgcggcgggt                                             20

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 21
ctcgcccgct cctcctcccc                                             20

<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 22
ctggcttctc ctcctcccct                                             20

<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 23
cgggaggcgg tcacattcgg                                             20

<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 24
tctggcgctg caccactctc                                             20

<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 25
ttctcgcccg ctcctcctcc                                             20

<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 26
ttctcctcct cccctggcag                                             20

<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 27
cctgctggct tctcctcctc                                             20


<210> 28
<211> 3291
<212> DNA
<213> Homo sapiens

<400> 28
agaatcggag agccggtggc gtcgcaggtc gggaggacga gcaccgagtc gagggctcgc 60
tcgtctgggc cgcccgagag tcttaatcgc gggcgcttgg gccgccatct tagatggcgg 120
gagtaagagg aaaacgattg tgaggcggga acggctttct gctgcctttt ttgggccccg 180
aaaagggtca gctggccggg ctttggggcg cgtgccctga ggcgcggagc gcgtttgcta 240
cgatgcgggg gctgctcggg gctccgtccc ctgggctggg gacgcgccga atgtgaccgc 300
ctcccgctcc ctcacccgcc gcggggagga ggagcgggcg agaagctgcc gccgaacgac 360
aggacgttgg ggcggcctgg ctccctcagg tttaagaatt gtttaagctg catcaatgga 420
gcacatacag ggagcttgga agacgatcag caatggtttt ggattcaaag atgccgtgtt 480
tgatggctcc agctgcatct ctcctacaat agttcagcag tttggctatc agcgccgggc 540
atcagatgat ggcaaactca cagatccttc taagacaagc aacactatcc gtgttttctt 600
gccgaacaag caaagaacag tggtcaatgt gcgaaatgga atgagcttgc atgactgcct 660
tatgaaagca ctcaaggtga ggggcctgca accagagtgc tgtgcagtgt tcagacttct 720
ccacgaacac aaaggtaaaa aagcacgctt agattggaat actgatgctg cgtctttgat 780
tggagaagaa cttcaagtag atttcctgga tcatgttccc ctcacaacac acaactttgc 840
tcggaagacg ttcctgaagc ttgccttctg tgacatctgt cagaaattcc tgctcaatgg 900
atttcgatgt cagacttgtg gctacaaatt tcatgagcac tgtagcacca aagtacctac 960
tatgtgtgtg gactggagta acatcagaca actcttattg tttccaaatt ccactattgg 1020
tgatagtgga gtcccagcac taccttcttt gactatgcgt cgtatgcgag agtctgtttc 1080
caggatgcct gttagttctc agcacagata ttctacacct cacgccttca cctttaacac 1140
ctccagtccc tcatctgaag gttccctctc ccagaggcag aggtcgacat ccacacctaa 1200
tgtccacatg gtcagcacca ccctgcctgt ggacagcagg atgattgagg atgcaattcg 1260
aagtcacagc gaatcagcct caccttcagc cctgtccagt agccccaaca atctgagccc 1320
aacaggctgg tcacagccga aaacccccgt gccagcacaa agagagcggg caccagtatc 1380
tgggacccag gagaaaaaca aaattaggcc tcgtggacag agagattcaa gctattattg 1440
ggaaatagaa gccagtgaag tgatgctgtc cactcggatt gggtcaggct cttttggaac 1500
tgtttataag ggtaaatggc acggagatgt tgcagtaaag atcctaaagg ttgtcgaccc 1560
aaccccagag caattccagg ccttcaggaa tgaggtggct gttctgcgca aaacacggca 1620
tgtgaacatt ctgcttttca tggggtacat gacaaaggac aacctggcaa ttgtgaccca 1680
gtggtgcgag ggcagcagcc tctacaaaca cctgcatgtc caggagacca agtttcagat 1740
gttccagcta attgacattg cccggcagac ggctcaggga atggactatt tgcatgcaaa 1800
gaacatcatc catagagaca tgaaatccaa caatatattt ctccatgaag gcttaacagt 1860
gaaaattgga gattttggtt tggcaacagt aaagtcacgc tggagtggtt ctcagcaggt 1920
tgaacaacct actggctctg tcctctggat ggccccagag gtgatccgaa tgcaggataa 1980
caacccattc agtttccagt cggatgtcta ctcctatggc atcgtattgt atgaactgat 2040
gacgggggag cttccttatt ctcacatcaa caaccgagat cagatcatct tcatggtggg 2100
ccgaggatat gcctccccag atcttagtaa gctatataag aactgcccca aagcaatgaa 2160
gaggctggta gctgactgtg tgaagaaagt aaaggaagag aggcctcttt ttccccagat 2220
cctgtcttcc attgagctgc tccaacactc tctaccgaag atcaaccgga gcgcttccga 2280
gccatccttg catcgggcag cccacactga ggatatcaat gcttgcacgc tgaccacgtc 2340
cccgaggctg cctgtcttct agttgacttt gcacctgtct tcaggctgcc aggggaggag 2400
gagaagccag caggcaccac ttttctgctc cctttctcca gaggcagaac acatgttttc 2460
agagaagctg ctgctaagga ccttctagac tgctcacagg gccttaactt catgttgcct 2520
tcttttctat ccctttgggc cctgggagaa ggaagccatt tgcagtgctg gtgtgtcctg 2580
ctccctcccc acattcccca tgctcaaggc ccagccttct gtagatgcgc aagtggatgt 2640
tgatggtagt acaaaaagca ggggcccagc cccagctgtt ggctacatga gtatttagag 2700
gaagtaaggt agcaggcagt ccagccctga tgtggagaca catgggattt tggaaatcag 2760
cttctggagg aatgcatgtc acaggcggga ctttcttcag agagtggtgc agcgccagac 2820
attttgcaca taaggcacca aacagcccag gactgccgag actctggccg cccgaaggag 2880
cctgctttgg tactatggaa cttttcttag gggacacgtc ctcctttcac agcttctaag 2940
gtgtccagtg cattgggatg gttttccagg caaggcactc ggccaatccg catctcagcc 3000
ctctcaggga gcagtcttcc atcatgctga attttgtctt ccaggagctg cccctatggg 3060
gcggggccgc agggccagcc ttgtttctct aacaaacaaa caaacaaaca gccttgtttc 3120
tctagtcaca tcatgtgtat acaaggaagc caggaataca ggttttcttg atgatttggg 3180
ttttaatttt gtttttattg cacctgacaa aatacagtta tctgatggtc cctcaattat 3240
gttattttaa taaaataaat taaatttagg tgtaaaaaaa aaaaaaaaaa a          3291

<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 29
ucccgcctgt gacaugcauu                                             20









