                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals S.A.
 
<120>  Immunogenic Composition

<130>  VB64165

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  136
<212>  PRT
<213>  Neisseria meningitidis

<400>  1

Cys Ser Ser Gly Gly Gly Gly Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Lys Val Ser Arg Phe Asp Phe Ile Arg Gln 
65                  70                  75                  80  


Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe Gln 
                85                  90                  95      


Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu Gln 
            100                 105                 110         


Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln Phe 
        115                 120                 125             


Arg Ile Gly Asp Ile Ala Gly Glu 
    130                 135     


<210>  2
<211>  119
<212>  PRT
<213>  Neisseria meningitidis

<400>  2

Gly Glu His Thr Ala Phe Asn Gln Leu Pro Asp Gly Lys Ala Glu Tyr 
1               5                   10                  15      


His Gly Lys Ala Phe Ser Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr 
            20                  25                  30          


Thr Ile Asp Phe Ala Ala Lys Gln Gly His Gly Lys Ile Glu His Leu 
        35                  40                  45              


Lys Thr Pro Glu Gln Asn Val Glu Leu Ala Ala Ala Glu Leu Lys Ala 
    50                  55                  60                  


Asp Glu Lys Ser His Ala Val Ile Leu Gly Asp Thr Arg Tyr Gly Ser 
65                  70                  75                  80  


Glu Glu Lys Gly Thr Tyr His Leu Ala Leu Phe Gly Asp Arg Ala Gln 
                85                  90                  95      


Glu Ile Ala Gly Ser Ala Thr Val Lys Ile Gly Glu Lys Val His Glu 
            100                 105                 110         


Ile Gly Ile Ala Gly Lys Gln 
        115                 


<210>  3
<211>  23
<212>  PRT
<213>  Neisseria meningitidis


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  "X" is I/T

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  "X" is Q/R

<400>  3

Lys Ile Asn Asn Pro Asp Lys Xaa Asp Ser Leu Ile Asn Xaa Arg Ser 
1               5                   10                  15      


Phe Leu Val Ser Gly Leu Gly 
            20              


<210>  4
<211>  23
<212>  PRT
<213>  Neisseria meningitidis


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  "X" is V/I/E

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  "X" is S/P

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  "X" is D/H

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  "X" is G/R

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  "X" is K/S

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  "X" is Q/R

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  "X" is R/K

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  "X" is A/V

<400>  4

Gln Xaa Gln Asp Xaa Glu Xaa Ser Xaa Xaa Met Val Ala Lys Arg Xaa 
1               5                   10                  15      


Phe Xaa Ile Gly Asp Ile Xaa 
            20              


<210>  5
<211>  255
<212>  PRT
<213>  Neisseria meningitidis strain MC58

<400>  5

Cys Ser Ser Gly Gly Gly Gly Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu 
            100                 105                 110         


Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln 
        115                 120                 125             


Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ser Phe Asp Lys Leu 
    130                 135                 140                 


Pro Glu Gly Gly Arg Ala Thr Tyr Arg Gly Thr Ala Phe Gly Ser Asp 
145                 150                 155                 160 


Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln 
                165                 170                 175     


Gly Asn Gly Lys Ile Glu His Leu Lys Ser Pro Glu Leu Asn Val Asp 
            180                 185                 190         


Leu Ala Ala Ala Asp Ile Lys Pro Asp Gly Lys Arg His Ala Val Ile 
        195                 200                 205             


Ser Gly Ser Val Leu Tyr Asn Gln Ala Glu Lys Gly Ser Tyr Ser Leu 
    210                 215                 220                 


Gly Ile Phe Gly Gly Lys Ala Gln Glu Val Ala Gly Ser Ala Glu Val 
225                 230                 235                 240 


Lys Thr Val Asn Gly Ile Arg His Ile Gly Leu Ala Ala Lys Gln 
                245                 250                 255 


<210>  6
<211>  768
<212>  DNA
<213>  Neisseria meningitidis strain MC58

<400>  6
tgcagcagcg gagggggtgg tgtcgccgcc gacatcggtg cggggcttgc cgatgcacta       60

accgcaccgc tcgaccataa agacaaaggt ttgcagtctt tgacgctgga tcagtccgtc      120

aggaaaaacg agaaactgaa gctggcggca caaggtgcgg aaaaaactta tggaaacggt      180

gacagcctca atacgggcaa attgaagaac gacaaggtca gccgtttcga ctttatccgc      240

caaatcgaag tggacgggca gctcattacc ttggagagtg gagagttcca agtatacaaa      300

caaagccatt ccgccttaac cgcctttcag accgagcaaa tacaagattc ggagcattcc      360

gggaagatgg ttgcgaaacg ccagttcaga atcggcgaca tagcgggcga acatacatct      420

tttgacaagc ttcccgaagg cggcagggcg acatatcgcg ggacggcgtt cggttcagac      480

gatgccggcg gaaaactgac ctacaccata gatttcgccg ccaagcaggg aaacggcaaa      540

atcgaacatt tgaaatcgcc agaactcaat gtcgacctgg ccgccgccga tatcaagccg      600

gatggaaaac gccatgccgt catcagcggt tccgtccttt acaaccaagc cgagaaaggc      660

agttactccc tcggtatctt tggcggaaaa gcccaggaag ttgccggcag cgcggaagtg      720

aaaaccgtaa acggcatacg ccatatcggc cttgccgcca agcaataa                   768


<210>  7
<211>  254
<212>  PRT
<213>  Neisseria meningitidis strain 8047

<400>  7

Cys Ser Ser Gly Gly Gly Gly Val Ala Ala Asp Ile Gly Ala Arg Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Ser Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Ile Tyr Lys Gln Asp His Ser Ala Val Val Ala Leu Gln Ile Glu 
            100                 105                 110         


Lys Ile Asn Asn Pro Asp Lys Ile Asp Ser Leu Ile Asn Gln Arg Ser 
        115                 120                 125             


Phe Leu Val Ser Gly Leu Gly Gly Glu His Thr Ala Phe Asn Gln Leu 
    130                 135                 140                 


Pro Asp Gly Lys Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp 
145                 150                 155                 160 


Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly 
                165                 170                 175     


His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu Leu 
            180                 185                 190         


Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu 
        195                 200                 205             


Gly Asp Thr Arg Tyr Gly Ser Glu Glu Lys Gly Thr Tyr His Leu Ala 
    210                 215                 220                 


Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser Ala Thr Val Lys 
225                 230                 235                 240 


Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250                 


<210>  8
<211>  765
<212>  DNA
<213>  Neisseria meningitidis strain 8047

<400>  8
tgcagcagcg gaggcggcgg tgtcgccgcc gacatcggcg cgaggcttgc cgatgcacta       60

accgcaccgc tcgaccataa agacaaaagt ttgcagtctt tgacgctgga tcagtccgtc      120

aggaaaaacg agaaactgaa gctggcggca caaggtgcgg aaaaaactta tggaaacggc      180

gacagcctca atacgggcaa attgaagaac gacaaggtca gccgcttcga ctttatccgt      240

caaatcgaag tggacgggca gctcattacc ttggagagcg gagagttcca aatatacaaa      300

caggaccact ccgccgtcgt tgccctacag attgaaaaaa tcaacaaccc cgacaaaatc      360

gacagcctga taaaccaacg ctccttcctt gtcagcggtt tgggcggaga acataccgcc      420

ttcaaccaac tgcctgacgg caaagccgag tatcacggca aagcattcag ctccgacgat      480

gctggcggaa aactgaccta taccatagat ttcgccgcca aacagggaca cggcaaaatc      540

gaacacctga aaacacccga gcaaaatgtc gagcttgccg ccgccgaact caaagcagat      600

gaaaaatcac acgccgtcat tttgggcgac acgcgctacg gcagcgaaga aaaaggcact      660

taccacctcg cccttttcgg cgaccgcgcc caagaaatcg ccggctcggc aaccgtgaag      720

ataggggaaa aggttcacga aatcggcatc gccggcaaac agtag                      765


<210>  9
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 27 to 273 of full length fHbp from Neisseria meningitidis 
       strain 8047 with histidine tag

<400>  9

Met His His His His His His Val Ala Ala Asp Ile Gly Ala Arg Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Ser Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Ile Tyr Lys Gln Asp His Ser Ala Val Val Ala Leu Gln Ile Glu 
            100                 105                 110         


Lys Ile Asn Asn Pro Asp Lys Ile Asp Ser Leu Ile Asn Gln Arg Ser 
        115                 120                 125             


Phe Leu Val Ser Gly Leu Gly Gly Glu His Thr Ala Phe Asn Gln Leu 
    130                 135                 140                 


Pro Asp Gly Lys Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp 
145                 150                 155                 160 


Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly 
                165                 170                 175     


His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu Leu 
            180                 185                 190         


Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu 
        195                 200                 205             


Gly Asp Thr Arg Tyr Gly Ser Glu Glu Lys Gly Thr Tyr His Leu Ala 
    210                 215                 220                 


Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser Ala Thr Val Lys 
225                 230                 235                 240 


Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250                 


<210>  10
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence for aa 27 to 273 of full length fHbp from 
       Neisseria meningitidis strain 8047 with histidine tag

<400>  10
atgcatcatc atcaccatca tgttgcagca gatattggtg cacgtctggc agatgcactg       60

accgcaccgc tggatcataa agataaaagc ctgcagagcc tgaccctgga tcagagcgtt      120

cgcaaaaatg aaaaactgaa actggcagca cagggtgcag aaaaaaccta tggtaatggc      180

gatagcctga ataccggcaa actgaaaaat gataaagtga gccgctttga ttttattcgc      240

cagattgaag ttgatggtca gctgattacc ctggaaagcg gtgaatttca gatttataaa      300

caggatcata gcgcagttgt tgcactgcag attgaaaaaa ttaataatcc ggataaaatt      360

gatagcctga ttaatcagcg tagctttctg gttagcggtc tgggtggtga acataccgca      420

tttaatcagc tgccggatgg taaagcagaa tatcatggca aagcctttag ctctgatgat      480

gccggtggta aactgaccta taccattgat tttgcagcca aacagggtca tggcaaaatt      540

gaacatctga aaacaccgga acagaatgtt gaactggcag cagcagaact gaaagcagat      600

gaaaaaagcc atgccgttat tctgggtgat acccgttatg gtagcgaaga aaaaggcacc      660

tatcatctgg cactgtttgg tgatcgtgca caggaaattg caggtagcgc aaccgttaaa      720

attggcgaaa aagtgcatga aattggcatt gccggtaaac ag                         762


<210>  11
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 73 to 320 of full length fHbp from Neisseria meningitidis 
       strain MC58 with histidine tag

<400>  11

Met His His His His His His Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu 
            100                 105                 110         


Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln 
        115                 120                 125             


Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ser Phe Asp Lys Leu 
    130                 135                 140                 


Pro Glu Gly Gly Arg Ala Thr Tyr Arg Gly Thr Ala Phe Gly Ser Asp 
145                 150                 155                 160 


Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln 
                165                 170                 175     


Gly Asn Gly Lys Ile Glu His Leu Lys Ser Pro Glu Leu Asn Val Asp 
            180                 185                 190         


Leu Ala Ala Ala Asp Ile Lys Pro Asp Gly Lys Arg His Ala Val Ile 
        195                 200                 205             


Ser Gly Ser Val Leu Tyr Asn Gln Ala Glu Lys Gly Ser Tyr Ser Leu 
    210                 215                 220                 


Gly Ile Phe Gly Gly Lys Ala Gln Glu Val Ala Gly Ser Ala Glu Val 
225                 230                 235                 240 


Lys Thr Val Asn Gly Ile Arg His Ile Gly Leu Ala Ala Lys Gln 
                245                 250                 255 


<210>  12
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence for aa 73 to 320 of full length fHbp from 
       Neisseria meningitidis strain MC58 with histidine tag

<400>  12
atgcatcatc atcaccatca tgttgcagca gatattggcg caggtctggc agatgcactg       60

accgctccgc tggatcataa agataaaggt ctgcagagcc tgaccctgga tcagagcgtt      120

cgcaaaaatg aaaaactgaa actggcagca cagggtgcag aaaaaaccta tggtaatggc      180

gatagcctga ataccggcaa actgaaaaat gataaagtga gccgctttga ttttattcgc      240

cagattgaag ttgatggtca gctgattacc ctggaaagcg gtgaatttca ggtgtataaa      300

cagagccata gcgcactgac cgcctttcag accgaacaaa ttcaggatag cgaacatagc      360

ggtaaaatgg ttgccaaacg ccagtttcgt attggtgata ttgccggtga acataccagc      420

tttgataaac tgccggaagg tggtcgtgca acctatcgtg gcaccgcatt tggttctgat      480

gatgccggtg gtaaactgac ctataccatt gattttgcag ccaaacaggg caatggcaaa      540

attgaacatc tgaaatctcc ggaactgaat gttgatctgg cagcagccga tattaaaccg      600

gatggtaaac gccatgcagt tattagcggt agcgtgctgt ataatcaggc agaaaaaggt      660

agctatagcc tgggtatttt tggtggtaaa gcacaggaag ttgcaggtag cgcagaagtt      720

aaaaccgtca acggcattcg tcatattggt ctggcagcga aacag                      765


<210>  13
<211>  7
<212>  PRT
<213>  Neisseria meningitidis (group B)

<400>  13

Cys Ser Ser Gly Gly Gly Gly 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine tag

<400>  14

Met His His His His His His 
1               5           


<210>  15
<211>  4
<212>  PRT
<213>  Neisseria meningitidis (group B)

<400>  15

Gly Glu His Thr 
1               


<210>  16
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein LVL491

<400>  16

Met His His His His His His Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu 
            100                 105                 110         


Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln 
        115                 120                 125             


Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ala Phe Asn Gln Leu 
    130                 135                 140                 


Pro Asp Gly Lys Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp 
145                 150                 155                 160 


Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly 
                165                 170                 175     


His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu Leu 
            180                 185                 190         


Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu 
        195                 200                 205             


Gly Asp Thr Arg Tyr Gly Ser Glu Glu Lys Gly Thr Tyr His Leu Ala 
    210                 215                 220                 


Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser Ala Thr Val Lys 
225                 230                 235                 240 


Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250                 


<210>  17
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence for fusion protein LVL491

<400>  17
atgcatcatc atcaccatca tgttgcagca gatattggcg caggtctggc agatgcactg       60

accgctccgc tggatcataa agataaaggt ctgcagagcc tgaccctgga tcagagcgtt      120

cgcaaaaatg aaaaactgaa actggcagca cagggtgcag aaaaaaccta tggtaatggc      180

gatagcctga ataccggcaa actgaaaaat gataaagtga gccgctttga ttttattcgc      240

cagattgaag ttgatggtca gctgattacc ctggaaagcg gtgaatttca ggtgtataaa      300

cagagccata gcgcactgac cgcctttcag accgaacaaa ttcaggatag cgaacatagc      360

ggtaaaatgg ttgccaaacg ccagtttcgt attggtgata ttgccggtga acataccgca      420

tttaatcagc tgccggatgg taaagcagaa tatcatggca aagcctttag ctctgatgat      480

gccggtggta aactgaccta taccattgat tttgcagcca aacagggtca tggcaaaatt      540

gaacatctga aaacaccgga acagaatgtt gaactggcag cagcagaact gaaagcagat      600

gaaaaaagcc atgccgttat tctgggtgat acccgttatg gtagcgaaga aaaaggcacc      660

tatcatctgg cactgtttgg tgatcgtgca caggaaattg caggtagcgc aaccgttaaa      720

attggcgaaa aagtgcatga aattggcatt gccggtaaac ag                         762


<210>  18
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein A

<400>  18

Met His His His His His His Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu 
            100                 105                 110         


Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln 
        115                 120                 125             


Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ala Phe Asn Gln Leu 
    130                 135                 140                 


Pro Asp Gly Lys Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp 
145                 150                 155                 160 


Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly 
                165                 170                 175     


His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu Leu 
            180                 185                 190         


Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu 
        195                 200                 205             


Gly Asp Thr Arg Tyr Gly Ser Glu Ala Lys Gly Thr Tyr His Leu Ala 
    210                 215                 220                 


Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser Ala Ala Val Lys 
225                 230                 235                 240 


Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250                 


<210>  19
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for Fusion protein A

<400>  19
tgcagcagcg gagggggtgg tgtcgccgcc gacatcggtg cggggcttgc cgatgcacta       60

accgcaccgc tcgaccataa agacaaaggt ttgcagtctt tgacgctgga tcagtccgtc      120

aggaaaaacg agaaactgaa gctggcggca caaggtgcgg aaaaaactta tggaaacggt      180

gacagcctca atacgggcaa attgaagaac gacaaggtca gccgtttcga ctttatccgc      240

caaatcgaag tggacgggca gctcattacc ttggagagtg gagagttcca agtatacaaa      300

caaagccatt ccgccttaac cgcctttcag accgagcaaa tacaagattc ggagcattcc      360

gggaagatgg ttgcgaaacg ccagttcaga atcggcgaca tagcgggaga acataccgcc      420

ttcaaccaac tgcctgacgg caaagccgag tatcacggca aagcattcag ctccgacgat      480

gctggcggaa aactgaccta taccatagat ttcgccgcca aacagggaca cggcaaaatc      540

gaacacctga aaacacccga gcaaaatgtc gagcttgccg ccgccgaact caaagcagat      600

gaaaaatcac acgccgtcat tttgggcgac acgcgctacg gcagcgaagc aaaaggcact      660

taccacctcg cccttttcgg cgaccgcgcc caagaaatcg ccggctcggc agccgtgaag      720

ataggggaaa aggttcacga aatcggcatc gccggcaaac agtag                      765


<210>  20
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein B

<400>  20

Met His His His His His His Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu 
            100                 105                 110         


Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln 
        115                 120                 125             


Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ala Phe Asn Gln Leu 
    130                 135                 140                 


Pro Asp Gly Lys Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp 
145                 150                 155                 160 


Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly 
                165                 170                 175     


His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu Leu 
            180                 185                 190         


Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu 
        195                 200                 205             


Gly Asp Thr Arg Tyr Gly Ser Glu Ala Lys Gly Thr Tyr His Leu Ala 
    210                 215                 220                 


Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser Ala Thr Val Lys 
225                 230                 235                 240 


Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250                 


<210>  21
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence for Fusion Protein B

<400>  21
atgcatcatc atcaccatca tgttgcagca gatattggcg caggtctggc agatgcactg       60

accgctccgc tggatcataa agataaaggt ctgcagagcc tgaccctgga tcagagcgtt      120

cgcaaaaatg aaaaactgaa actggcagca cagggtgcag aaaaaaccta tggtaatggc      180

gatagcctga ataccggcaa actgaaaaat gataaagtga gccgctttga ttttattcgc      240

cagattgaag ttgatggtca gctgattacc ctggaaagcg gtgaatttca ggtgtataaa      300

cagagccata gcgcactgac cgcctttcag accgaacaaa ttcaggatag cgaacatagc      360

ggtaaaatgg ttgccaaacg ccagtttcgt attggtgata ttgccggtga acataccgca      420

tttaatcagc tgccggatgg taaagcagaa tatcatggca aagcctttag ctctgatgat      480

gccggtggta aactgaccta taccattgat tttgcagcca aacagggtca tggcaaaatt      540

gaacatctga aaacaccgga acagaatgtt gaactggcag cagcagaact gaaagcagat      600

gaaaaaagcc atgccgttat tctgggtgat acccgttatg gtagcgaagc aaaaggcacc      660

tatcatctgg cactgtttgg tgatcgtgca caggaaattg caggtagcgc aaccgttaaa      720

attggcgaaa aagtgcatga aattggcatt gccggtaaac ag                         762


<210>  22
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein C

<400>  22

Met His His His His His His Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu 
            100                 105                 110         


Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln 
        115                 120                 125             


Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ala Phe Asn Gln Leu 
    130                 135                 140                 


Pro Glu Gly Gly Arg Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp 
145                 150                 155                 160 


Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln 
                165                 170                 175     


Gly His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu 
            180                 185                 190         


Leu Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Arg His Ala Val Ile 
        195                 200                 205             


Leu Gly Asp Thr Arg Tyr Gly Ser Glu Ala Lys Gly Thr Tyr His Leu 
    210                 215                 220                 


Ala Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser Ala Ala Val 
225                 230                 235                 240 


Lys Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250                 255 


<210>  23
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic sequence of Fusion Protein C

<400>  23
atgcatcatc atcaccatca tgttgcagca gatattggcg caggtctggc agatgcactg       60

accgctccgc tggatcataa agataaaggt ctgcagagcc tgaccctgga tcagagcgtt      120

cgcaaaaatg aaaaactgaa actggcagca cagggtgcag aaaaaaccta tggtaatggc      180

gatagcctga ataccggcaa actgaaaaat gataaagtga gccgctttga ttttattcgc      240

cagattgaag ttgatggtca gctgattacc ctggaaagcg gtgaatttca ggtgtataaa      300

cagagccata gcgcactgac cgcctttcag accgaacaaa ttcaggatag cgaacatagc      360

ggtaaaatgg ttgccaaacg ccagtttcgt attggtgata ttgccggtga acataccgca      420

tttaatcagc tgccggaagg tggtcgtgca gaatatcatg gcaaagcctt tagctctgat      480

gatgccggtg gtaaactgac ctataccatt gattttgcag ccaaacaggg tcatggcaaa      540

attgaacatc tgaaaacacc ggaacagaat gttgaactgg cagcagcaga actgaaagca      600

gatgaaaaac gtcatgccgt tattctgggt gatacccgtt atggtagcga agcaaaaggc      660

acctatcatc tggcactgtt tggtgatcgc gcacaggaaa ttgcaggtag cgcagcagtt      720

aaaattggcg aaaaagtgca tgaaattggc attgccggta aacag                      765


<210>  24
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein E

<400>  24

Met His His His His His His Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      


Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          


Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              


Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  


Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  


Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      


Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu 
            100                 105                 110         


Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln 
        115                 120                 125             


Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ala Phe Asn Gln Leu 
    130                 135                 140                 


Pro Glu Gly Gly Arg Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp 
145                 150                 155                 160 


Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln 
                165                 170                 175     


Gly His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu 
            180                 185                 190         


Leu Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Arg His Ala Val Ile 
        195                 200                 205             


Leu Gly Asp Thr Arg Tyr Gly Ser Glu Ala Lys Gly Thr Tyr His Leu 
    210                 215                 220                 


Ala Leu Phe Gly Asp Lys Ala Gln Glu Ile Ala Gly Ser Ala Ala Val 
225                 230                 235                 240 


Lys Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250                 255 


<210>  25
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic sequence for Fusion Protein E

<400>  25
atgcatcatc atcaccatca tgttgcagca gatattggcg caggtctggc agatgcactg       60

accgctccgc tggatcataa agataaaggt ctgcagagcc tgaccctgga tcagagcgtt      120

cgcaaaaatg aaaaactgaa actggcagca cagggtgcag aaaaaaccta tggtaatggc      180

gatagcctga ataccggcaa actgaaaaat gataaagtga gccgctttga ttttattcgc      240

cagattgaag ttgatggtca gctgattacc ctggaaagcg gtgaatttca ggtgtataaa      300

cagagccata gcgcactgac cgcctttcag accgaacaaa ttcaggatag cgaacatagc      360

ggtaaaatgg ttgccaaacg ccagtttcgt attggtgata ttgccggtga acataccgca      420

tttaatcagc tgccggaagg tggtcgtgca gaatatcatg gcaaagcctt tagctctgat      480

gatgccggtg gtaaactgac ctataccatt gattttgcag ccaaacaggg tcatggcaaa      540

attgaacatc tgaaaacacc ggaacagaat gttgaactgg cagcagcaga actgaaagca      600

gatgaaaaac gtcatgccgt tattctgggt gatacccgtt atggtagcga agcaaaaggc      660

acctatcatc tggcactgtt tggtgataaa gcacaggaaa ttgcaggtag cgcagcagtt      720

aaaattggcg aaaaagtgca tgaaattggc attgccggta aacag                      765


<210>  26
<211>  4
<212>  PRT
<213>  Neisseria meningitidis (group B)

<400>  26

Arg Glu Lys Val 
1               


<210>  27
<211>  4
<212>  PRT
<213>  Neisseria meningitidis (group B)

<400>  27

Val Asn Gly Ile 
1               


