                         SEQUENCE LISTING

<110>  UCB PHARMA S.A.
 
<120>  PD-1 Antibody

<130>  G0131-WO01

<150>  61/312702
<151>  2010-03-11

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  1

Gly Tyr Thr Phe Thr Thr Tyr Pro Ile Glu 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  2

Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  3

Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr 
1               5                   10      


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  4

Arg Ala Ser Ser Ser Val Ile Ser Ser Tyr Leu His 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  5

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  6

Gln Gln Tyr Asn Gly Tyr Pro Leu Thr 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  7

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  8

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  10

Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  11
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  11
gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca       60

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      120

cccgccaaag ctcctaagct ctggatctac tccacctcca acttggcatc tggcgtgcct      180

gatagatttt ctgggagcgg ttccgggaca agctataccc tgacgattag ttccctgcaa      240

ccggaggact tcgccaccta ttactgtcag cagtacaacg gctacccact gacattcggc      300

ggagggacta aagtcgaaat caag                                             324


<210>  12
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  12

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ile Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  13
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  13
atgagtgtgc caactcaggt tctcggattg ctgcttctgt ggcttactga tgcccgctgc       60

gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca      120

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      180

cccgccaaag ctcctaagct ctggatctac tccacctcca acttggcatc tggcgtgcct      240

gatagatttt ctgggagcgg ttccgggaca agctataccc tgacgattag ttccctgcaa      300

ccggaggact tcgccaccta ttactgtcag cagtacaacg gctacccact gacattcggc      360

ggagggacta aagtcgaaat caag                                             384


<210>  14
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  14

Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  15
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  15
gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca       60

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      120

cccgccaaag ctcctaagct ctggatctac tccacctcca acttggcatc tggcgtgcct      180

gatagatttt ctgggagcgg ttccgggaca agctataccc tgacgattag ttccctgcaa      240

ccggaggact tcgccaccta ttactgtcag cagtacaacg gctacccact gacattcggc      300

ggagggacta aagtcgaaat caagcgtacg gtagcggccc catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  16
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  16

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ile Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  17
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  17
atgagtgtgc caactcaggt tctcggattg ctgcttctgt ggcttactga tgcccgctgc       60

gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca      120

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      180

cccgccaaag ctcctaagct ctggatctac tccacctcca acttggcatc tggcgtgcct      240

gatagatttt ctgggagcgg ttccgggaca agctataccc tgacgattag ttccctgcaa      300

ccggaggact tcgccaccta ttactgtcag cagtacaacg gctacccact gacattcggc      360

ggagggacta aagtcgaaat caagcgtacg gtagcggccc catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  18
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  18

Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  19
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  19
gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca       60

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      120

cccgccaaag ctcctaagct cttcatctac tccacctcca acttggcatc tggcgtgcct      180

agcagatttt ctgggagcgg ttccgggaca gactataccc tgacgattag ttccctgcaa      240

ccggaggact tcgccaccta ttactgtcag cagtacaacg gctacccact gacattcggc      300

ggagggacta aagtcgaaat caag                                             324


<210>  20
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  20

Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  21
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  21
gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca       60

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      120

cccgccaaag ctcctaagct ctggatctac tccacctcca acttggcatc tggcgtgcct      180

gatagatttt ctgggagcgg ttccgggaca agctataccc tgacgattag ttccctgcaa      240

ccggaggact tcgccaccta ttactgtcag cagtacaact cctacccact gacattcggc      300

ggagggacta aagtcgaaat caag                                             324


<210>  22
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  22

Glu Asn Val Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  23
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  23
gagaatgtga tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca       60

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      120

cccgccaaag ctcctaagct cttcatctac tccacctcca acttggcatc tggcgtgcct      180

agcagatttt ctgggagcgg ttccgggaca gactataccc tgacgattag ttccctgcaa      240

ccggaggact tcgccaccta ttactgtcag cagtacaacg gctacccact gacattcggc      300

ggagggacta aagtcgaaat caag                                             324


<210>  24
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  24

Glu Asn Val Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  25
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  25
gagaatgtga tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca       60

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      120

cccgccaaag ctcctaagct cttcatctac tccacctcca acttggcatc tggcgtgcct      180

agcagatttt ctgggagcgg ttccgggaca gactataccc tgacgattag ttccctgcaa      240

ccggaggact tcgccaccta ttactgtcag cagtacaact cctacccact gacattcggc      300

ggagggacta aagtcgaaat caag                                             324


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  26

Glu Asn Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  27
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  27
gaaaacgtcc tgacacaatc tccgggtaca ctgtcactga gccctggaga gagagctacc       60

ttgagctgcc gagcctcaag tagcgtgatt agctcctacc tgcactggta tcagcaaaag      120

cctgggcaag caccaaggct gtggatctat agcacctcca atctggcctc tggtgtgcct      180

gacagattct ctggctctgg gtctggaacc tcctacaccc tgactatatc acgcctggag      240

ccagaggact tcgccacata ctactgccag cagtacaacg gctatcccct gacctttggc      300

ggagggacta aggtggaaat caaa                                             324


<210>  28
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  28

Glu Asn Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  29
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  29
gaaaacgtcc tgacacaatc tccgggtaca ctgtcactga gccctggaga gagagctacc       60

ttgagctgcc gagcctcaag tagcgtgatt agctcctacc tgcactggta tcagcaaaag      120

cctgggcaag caccaaggct gtggatctat agcacctcca atctggcctc tggtgtgcct      180

gacagattct ctggctctgg gtctggaacc tcctacaccc tgactatatc acgcctggag      240

ccagaggact tcgccacata ctactgccag cagtacaact cctatcccct gacctttggc      300

ggagggacta aggtggaaat caaa                                             324


<210>  30
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  30

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  31
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  31
gaagtgcaac tggtgcagtc tggagctgaa gtgaagaaac ctggtgctag cgtcaaagtg       60

tcctgcaaag ccttcggcta taccttcacc acgtacccaa ttgagtggat gaggcaggca      120

cacggacaag gattggagtg gatcggcaac tttcacccct acaacgacga cacgaagtac      180

aacgagaagt tcaagggtcg cgtgacaatg accgtcgata agagcacgac cactgtttat      240

atggagctga gctcactgag atccgaagat actgccgtct actattgtgc ccgagagaat      300

tacggatcac acgggggatt tgtttactgg ggacaaggca cactggttac cgtctcg         357


<210>  32
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  32

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Thr 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135             


<210>  33
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  33
atggaatgga gctgggtctt tctcttcttc ctgtccgtga caactggtgt gcactctgaa       60

gtgcaactgg tgcagtctgg agctgaagtg aagaaacctg gtgctagcgt caaagtgtcc      120

tgcaaagcct tcggctatac cttcaccacg tacccaattg agtggatgag gcaggcacac      180

ggacaaggat tggagtggat cggcaacttt cacccctaca acgacgacac gaagtacaac      240

gagaagttca agggtcgcgt gacaatgacc gtcgataaga gcacgaccac tgtttatatg      300

gagctgagct cactgagatc cgaagatact gccgtctact attgtgcccg agagaattac      360

ggatcacacg ggggatttgt ttactgggga caaggcacac tggttaccgt ctcg            414


<210>  34
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  35
<211>  1948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  35
gaagtgcaac tggtgcagtc tggagctgaa gtgaagaaac ctggtgctag cgtcaaagtg       60

tcctgcaaag ccttcggcta taccttcacc acgtacccaa ttgagtggat gaggcaggca      120

cacggacaag gattggagtg gatcggcaac tttcacccct acaacgacga cacgaagtac      180

aacgagaagt tcaagggtcg cgtgacaatg accgtcgata agagcacgac cactgtttat      240

atggagctga gctcactgag atccgaagat actgccgtct actattgtgc ccgagagaat      300

tacggatcac acgggggatt tgtttactgg ggacaaggca cactggttac cgtctcgagc      360

gcttctacaa agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      420

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      600

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttggtgag      660

aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagccctc ctgcctggac      720

gcaccccggc tgtgcagccc cagcccaggg cagcaaggca tgccccatct gtctcctcac      780

ccggaggcct ctgaccaccc cactcatgcc cagggagagg gtcttctgga tttttccacc      840

aggctccggg cagccacagg ctggatgccc ctaccccagg ccctgcgcat acaggggcag      900

gtgctgcgct cagacctgcc aagagccata tccgggagga ccctgcccct gacctaagcc      960

caccccaaag gccaaactct ccactccctc agctcagaca ccttctctcc tcccagatct     1020

gagtaactcc caatcttctc tctgcagagt ccaaatatgg tcccccatgc ccaccatgcc     1080

caggtaagcc aacccaggcc tcgccctcca gctcaaggcg ggacaggtgc cctagagtag     1140

cctgcatcca gggacaggcc ccagccgggt gctgacgcat ccacctccat ctcttcctca     1200

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact     1260

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac     1320

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag     1380

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1440

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1500

tccatcgaga aaaccatctc caaagccaaa ggtgggaccc acggggtgcg agggccacat     1560

ggacagaggt cagctcggcc caccctctgc cctgggagtg accgctgtgc caacctctgt     1620

ccctacaggg cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat     1680

gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc     1740

cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct     1800

ggactccgac ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca     1860

ggaggggaat gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca     1920

gaagagcctc tccctgtctc tgggtaaa                                        1948


<210>  36
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  36

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Thr 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230                 235                 240 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys 
465     


<210>  37
<211>  2005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  37
atggaatgga gctgggtctt tctcttcttc ctgtccgtga caactggtgt gcactctgaa       60

gtgcaactgg tgcagtctgg agctgaagtg aagaaacctg gtgctagcgt caaagtgtcc      120

tgcaaagcct tcggctatac cttcaccacg tacccaattg agtggatgag gcaggcacac      180

ggacaaggat tggagtggat cggcaacttt cacccctaca acgacgacac gaagtacaac      240

gagaagttca agggtcgcgt gacaatgacc gtcgataaga gcacgaccac tgtttatatg      300

gagctgagct cactgagatc cgaagatact gccgtctact attgtgcccg agagaattac      360

ggatcacacg ggggatttgt ttactgggga caaggcacac tggttaccgt ctcgagcgct      420

tctacaaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      480

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      660

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tggtgagagg      720

ccagcacagg gagggagggt gtctgctgga agccaggctc agccctcctg cctggacgca      780

ccccggctgt gcagccccag cccagggcag caaggcatgc cccatctgtc tcctcacccg      840

gaggcctctg accaccccac tcatgcccag ggagagggtc ttctggattt ttccaccagg      900

ctccgggcag ccacaggctg gatgccccta ccccaggccc tgcgcataca ggggcaggtg      960

ctgcgctcag acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac     1020

cccaaaggcc aaactctcca ctccctcagc tcagacacct tctctcctcc cagatctgag     1080

taactcccaa tcttctctct gcagagtcca aatatggtcc cccatgccca ccatgcccag     1140

gtaagccaac ccaggcctcg ccctccagct caaggcggga caggtgccct agagtagcct     1200

gcatccaggg acaggcccca gccgggtgct gacgcatcca cctccatctc ttcctcagca     1260

cctgagttcc tggggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc     1320

atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc     1380

gaggtccagt tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg     1440

cgggaggagc agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1500

gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc     1560

atcgagaaaa ccatctccaa agccaaaggt gggacccacg gggtgcgagg gccacatgga     1620

cagaggtcag ctcggcccac cctctgccct gggagtgacc gctgtgccaa cctctgtccc     1680

tacagggcag ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac     1740

caagaaccag gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt     1800

ggagtgggag agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga     1860

ctccgacggc tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga     1920

ggggaatgtc ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa     1980

gagcctctcc ctgtctctgg gtaaa                                           2005


<210>  38
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  38

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  39
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  39
gaagtgcaac tggtgcagtc tggagctgaa gtgaagaaac ctggtgctag cgtcaaagtg       60

tcctgcaaag ccttcggcta taccttcacc acgtacccaa ttgagtggat gaggcaggca      120

cacggacaag gattggagtg gatcggcaac tttcacccct acaacgacga cacgaagtac      180

aacgagaagt tcaagggtcg cgtgacaatg accagggata ccagcacgag cactgtttat      240

atggagctga gctcactgag atccgaagat actgccgtct actattgtgc ccgagagaat      300

tacggatcac acgggggatt tgtttactgg ggacaaggca cactggttac cgtctcg         357


<210>  40
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  40

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  41
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  41
gaagtgcaac tggtgcagtc tggagctgaa gtgaagaaac ctggtgctag cgtcaaagtg       60

tcctgcaaag ccttcggcta taccttcacc acgtacccaa ttgagtgggt gaggcaggca      120

cccggacaag gattggagtg gatgggcaac tttcacccct acaacgacga cacgaagtac      180

aacgagaagt tcaagggtcg cgtgacaatg accagggata ccagcacgag cactgtttat      240

atggagctga gctcactgag atccgaagat actgccgtct actattgtgc ccgagagaat      300

tacggatcac acgggggatt tgtttactgg ggacaaggca cactggttac cgtctcg         357


<210>  42
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  42

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  43
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  43
gaagtgcagc ttgtgcaaag cggcgctgag gtcaaaaagc ccggatcaag cgtgaaagtc       60

tcatgcaaag ccttcggcta caccttcaca acgtacccta tcgagtggat gaggcaggct      120

catggccaag gactggaatg gattgggaac ttccacccat acaacgacga caccaagtac      180

aacgagaagt tcaaggggcg cgttactata accgtggaca agagcactac caccgtgtac      240

atggagctga gcagtctgag aagcgaggat acagccgtgt actattgtgc acgggagaat      300

tatggctctc acggcggatt tgtgtactgg ggccaaggaa cactggttac tgtctcg         357


<210>  44
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  44

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  45
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  45
gaagtgcagc ttgtgcaaag cggcgctgag gtcaaaaagc ccggatcaag cgtgaaagtc       60

tcatgcaaag ccttcggcta caccttcaca acgtacccta tcgagtggat gaggcaggct      120

catggccaag gactggaatg gattgggaac ttccacccat acaacgacga caccaagtac      180

aacgagaagt tcaaggggcg cgttactata accgccgaca agagcactag caccgcctac      240

atggagctga gcagtctgag aagcgaggat acagccgtgt actattgtgc acgggagaat      300

tatggctctc acggcggatt tgtgtactgg ggccaaggaa cactggttac tgtctcg         357


<210>  46
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  47
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  47
gaagtgcagc ttgtgcaaag cggcgctgag gtcaaaaagc ccggatcaag cgtgaaagtc       60

tcatgcaaag ccagcggcta caccttcaca acgtacccta tcgagtgggt gaggcaggct      120

cccggccaag gactggaatg gatggggaac ttccacccat acaacgacga caccaagtac      180

aacgagaagt tcaaggggcg cgttactata accgccgaca agagcactag caccgcctac      240

atggagctga gcagtctgag aagcgaggat acagccgtgt actattgtgc acgggagaat      300

tatggctctc acggcggatt tgtgtactgg ggccaaggaa cactggttac tgtctcg         357


<210>  48
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  48

Ala Ile Arg Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  49
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  49
gccatccgga tgacccagtc tccattctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgct gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gcaaaagccc ctaagctctt catctattat gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacggat tacactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tattatagta cccctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  50
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  50

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  51
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  51
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  52
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


<210>  53
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  53
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatacttt      300

gactactggg gccagggaac cctggtcacc gtctcc                                336


<210>  54
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


<210>  55
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  55
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatacttt      300

gactactggg gccagggaac cctggtcacc gtctcc                                336


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  56

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
1               5                   10                  


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  57

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  58
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  58

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  59
<211>  1945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  59
gaagtgcaac tggtgcagtc tggagctgaa gtgaagaaac ctggtgctag cgtcaaagtg       60

tcctgcaaag ccttcggcta taccttcacc acgtacccaa ttgagtggat gaggcaggca      120

cacggacaag gattggagtg gatcggcaac tttcacccct acaacgacga cacgaagtac      180

aacgagaagt tcaagggtcg cgtgacaatg accgtcgata agagcacgac cactgtttat      240

atggagctga gctcactgag atccgaagat actgccgtct actattgtgc ccgagagaat      300

tacggatcac acgggggatt tgtttactgg ggacaaggca cactggttac cgtctcgagc      360

gcttctacaa agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      420

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      600

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttggtgag      660

aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagccctc ctgcctggac      720

gcaccccggc tgtgcagccc cagcccaggg cagcaaggca tgccccatct gtctcctcac      780

ccggaggcct ctgaccaccc cactcatgcc cagggagagg gtcttctgga tttttccacc      840

aggctccggg cagccacagg ctggatgccc ctaccccagg ccctgcgcat acaggggcag      900

gtgctgcgct cagacctgcc aagagccata tccgggagga ccctgcccct gacctaagcc      960

caccccaaag gccaaactct ccactccctc agctcagaca ccttctctcc tcccagatct     1020

gagtaactcc caatcttctc tctgcagagt ccaaatatgg tcccccatgc ccaccatgcc     1080

caggtaagcc aacccaggcc tcgccctcca gctcaaggcg ggacaggtgc cctagagtag     1140

cctgcatcca gggacaggcc ccagccgggt gctgacgcat ccacctccat ctcttcctca     1200

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact     1260

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac     1320

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag     1380

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1440

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1500

tccatcgaga aaaccatctc caaagccaaa ggtgggaccc acggggtgcg agggccacat     1560

ggacagaggt cagctcggcc caccctctgc cctgggagtg accgctgtgc caacctctgt     1620

ccctacaggg cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat     1680

gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc     1740

cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct     1800

ggactccgac ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca     1860

ggaggggaat gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca     1920

gaagagcctc tccctgtctc tgggt                                           1945


<210>  60
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  60

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Thr 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230                 235                 240 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly 
465 


<210>  61
<211>  2002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  61
atggaatgga gctgggtctt tctcttcttc ctgtccgtga caactggtgt gcactctgaa       60

gtgcaactgg tgcagtctgg agctgaagtg aagaaacctg gtgctagcgt caaagtgtcc      120

tgcaaagcct tcggctatac cttcaccacg tacccaattg agtggatgag gcaggcacac      180

ggacaaggat tggagtggat cggcaacttt cacccctaca acgacgacac gaagtacaac      240

gagaagttca agggtcgcgt gacaatgacc gtcgataaga gcacgaccac tgtttatatg      300

gagctgagct cactgagatc cgaagatact gccgtctact attgtgcccg agagaattac      360

ggatcacacg ggggatttgt ttactgggga caaggcacac tggttaccgt ctcgagcgct      420

tctacaaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      480

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      660

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tggtgagagg      720

ccagcacagg gagggagggt gtctgctgga agccaggctc agccctcctg cctggacgca      780

ccccggctgt gcagccccag cccagggcag caaggcatgc cccatctgtc tcctcacccg      840

gaggcctctg accaccccac tcatgcccag ggagagggtc ttctggattt ttccaccagg      900

ctccgggcag ccacaggctg gatgccccta ccccaggccc tgcgcataca ggggcaggtg      960

ctgcgctcag acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac     1020

cccaaaggcc aaactctcca ctccctcagc tcagacacct tctctcctcc cagatctgag     1080

taactcccaa tcttctctct gcagagtcca aatatggtcc cccatgccca ccatgcccag     1140

gtaagccaac ccaggcctcg ccctccagct caaggcggga caggtgccct agagtagcct     1200

gcatccaggg acaggcccca gccgggtgct gacgcatcca cctccatctc ttcctcagca     1260

cctgagttcc tggggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc     1320

atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc     1380

gaggtccagt tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg     1440

cgggaggagc agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1500

gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc     1560

atcgagaaaa ccatctccaa agccaaaggt gggacccacg gggtgcgagg gccacatgga     1620

cagaggtcag ctcggcccac cctctgccct gggagtgacc gctgtgccaa cctctgtccc     1680

tacagggcag ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac     1740

caagaaccag gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt     1800

ggagtgggag agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga     1860

ctccgacggc tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga     1920

ggggaatgtc ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa     1980

gagcctctcc ctgtctctgg gt                                              2002


<210>  62
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  62

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  63
<211>  1953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  63
gaagtgcaac tggtgcagtc tggagctgaa gtgaagaaac ctggtgctag cgtcaaagtg       60

tcctgcaaag ccttcggcta taccttcacc acgtacccaa ttgagtggat gaggcaggca      120

cacggacaag gattggagtg gatcggcaac tttcacccct acaacgacga cacgaagtac      180

aacgagaagt tcaagggtcg cgtgacaatg accgtcgata agagcacgac cactgtttat      240

atggagctga gctcactgag atccgaagat actgccgtct actattgtgc ccgagagaat      300

tacggatcac acgggggatt tgtttactgg ggacaaggca cactggttac cgtctcgagc      360

gcttctacaa agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttggtgag      660

aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagcgctc ctgcctggac      720

gcatcccggc tatgcagccc cagtccaggg cagcaaggca ggccccgtct gcctcttcac      780

ccggaggcct ctgcccgccc cactcatgct cagggagagg gtcttctggc tttttcccca      840

ggctctgggc aggcacaggc taggtgcccc taacccaggc cctgcacaca aaggggcagg      900

tgctgggctc agacctgcca agagccatat ccgggaggac cctgcccctg acctaagccc      960

accccaaagg ccaaactctc cactccctca gctcggacac cttctctcct cccagatctg     1020

agtaactccc aatcttctct ctgcagagcc caaatcttgt gacaaaactc acacatgccc     1080

accgtgccca ggtaagccag cccaggcctc gccctccagc tcaaggcggg acaggtgccc     1140

tagagtagcc tgcatccagg gacaggcccc agccgggtgc tgacacgtcc acctccatct     1200

cttcctcagc acctgaactc ctggggggac cgtcagtctt cctcttcccc ccaaaaccca     1260

aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg gacgtgagcc     1320

acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca     1380

agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg     1440

tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc aacaaagccc     1500

tcccagcccc catcgagaaa accatctcca aagccaaagg tgggacccgt ggggtgcgag     1560

ggccacatgg acagaggccg gctcggccca ccctctgccc tgagagtgac cgctgtacca     1620

acctctgtcc ctacagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1680

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1740

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1800

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1860

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1920

tacacgcaga agagcctctc cctgtctccg ggt                                  1953


<210>  64
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  64

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Pro Ile Glu Trp Met Arg Gln Ala His Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Thr 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly 
465             


<210>  65
<211>  2010
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  65
atggaatgga gctgggtctt tctcttcttc ctgtccgtga caactggtgt gcactctgaa       60

gtgcaactgg tgcagtctgg agctgaagtg aagaaacctg gtgctagcgt caaagtgtcc      120

tgcaaagcct tcggctatac cttcaccacg tacccaattg agtggatgag gcaggcacac      180

ggacaaggat tggagtggat cggcaacttt cacccctaca acgacgacac gaagtacaac      240

gagaagttca agggtcgcgt gacaatgacc gtcgataaga gcacgaccac tgtttatatg      300

gagctgagct cactgagatc cgaagatact gccgtctact attgtgcccg agagaattac      360

ggatcacacg ggggatttgt ttactgggga caaggcacac tggttaccgt ctcgagcgct      420

tctacaaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tggtgagagg      720

ccagcacagg gagggagggt gtctgctgga agccaggctc agcgctcctg cctggacgca      780

tcccggctat gcagccccag tccagggcag caaggcaggc cccgtctgcc tcttcacccg      840

gaggcctctg cccgccccac tcatgctcag ggagagggtc ttctggcttt ttccccaggc      900

tctgggcagg cacaggctag gtgcccctaa cccaggccct gcacacaaag gggcaggtgc      960

tgggctcaga cctgccaaga gccatatccg ggaggaccct gcccctgacc taagcccacc     1020

ccaaaggcca aactctccac tccctcagct cggacacctt ctctcctccc agatctgagt     1080

aactcccaat cttctctctg cagagcccaa atcttgtgac aaaactcaca catgcccacc     1140

gtgcccaggt aagccagccc aggcctcgcc ctccagctca aggcgggaca ggtgccctag     1200

agtagcctgc atccagggac aggccccagc cgggtgctga cacgtccacc tccatctctt     1260

cctcagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg     1320

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg     1380

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga     1440

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc     1500

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc     1560

cagcccccat cgagaaaacc atctccaaag ccaaaggtgg gacccgtggg gtgcgagggc     1620

cacatggaca gaggccggct cggcccaccc tctgccctga gagtgaccgc tgtaccaacc     1680

tctgtcccta cagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1740

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1800

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1860

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1920

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1980

acgcagaaga gcctctccct gtctccgggt                                      2010


<210>  66
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  66

Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  67
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  67
gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca       60

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      120

cccgccaaag ctcctaagct cttcatctac tccacctcca acttggcatc tggcgtgcct      180

agcagatttt ctgggagcgg ttccgggaca gactataccc tgacgattag ttccctgcaa      240

ccggaggact tcgccaccta ttactgtcag cagtacaact cctacccact gacattcggc      300

ggagggacta aagtcgaaat caag                                             324


<210>  68
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  68

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ile Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala 
    50                  55                  60                  


Pro Lys Leu Phe Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  69
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  69
atgagtgtgc caactcaggt tctcggattg ctgcttctgt ggcttactga tgcccgctgc       60

gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca      120

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      180

cccgccaaag ctcctaagct cttcatctac tccacctcca acttggcatc tggcgtgcct      240

agcagatttt ctgggagcgg ttccgggaca gactataccc tgacgattag ttccctgcaa      300

ccggaggact tcgccaccta ttactgtcag cagtacaact cctacccact gacattcggc      360

ggagggacta aagtcgaaat caag                                             384


<210>  70
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  70

Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ile Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  71
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  71
gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca       60

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      120

cccgccaaag ctcctaagct cttcatctac tccacctcca acttggcatc tggcgtgcct      180

agcagatttt ctgggagcgg ttccgggaca gactataccc tgacgattag ttccctgcaa      240

ccggaggact tcgccaccta ttactgtcag cagtacaact cctacccact gacattcggc      300

ggagggacta aagtcgaaat caagcgtacg gtagcggccc catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  72
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  72

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Asn Val Leu Thr Gln Ser Pro Phe Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ile Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Ala Lys Ala 
    50                  55                  60                  


Pro Lys Leu Phe Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  73
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  73
atgagtgtgc caactcaggt tctcggattg ctgcttctgt ggcttactga tgcccgctgc       60

gagaatgtgc tgacacagag ccccttttca ctgtctgcat ctgtgggaga ccgggtcaca      120

ataacctgca gggctagctc aagcgtgatc agctcatacc tgcactggta tcagcaaaag      180

cccgccaaag ctcctaagct cttcatctac tccacctcca acttggcatc tggcgtgcct      240

agcagatttt ctgggagcgg ttccgggaca gactataccc tgacgattag ttccctgcaa      300

ccggaggact tcgccaccta ttactgtcag cagtacaact cctacccact gacattcggc      360

ggagggacta aagtcgaaat caagcgtacg gtagcggccc catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705

<210>  74
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  74

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Pro Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135             


<210>  75
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  75
atggagtggt cctgggtgtt tctcttcttt ctctccgtca caacgggtgt tcatagcgaa       60

gtgcagcttg tgcaaagcgg cgctgaggtc aaaaagcccg gatcaagcgt gaaagtctca      120

tgcaaagcca gcggctacac cttcacaacg taccctatcg agtgggtgag gcaggctccc      180

ggccaaggac tggaatggat ggggaacttc cacccataca acgacgacac caagtacaac      240

gagaagttca aggggcgcgt tactataacc gccgacaaga gcactagcac cgcctacatg      300

gagctgagca gtctgagaag cgaggataca gccgtgtact attgtgcacg ggagaattat      360

ggctctcacg gcggatttgt gtactggggc caaggaacac tggttactgt ctcg            414


<210>  76
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  76

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  77
<211>  1945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  77
gaagtgcagc ttgtgcaaag cggcgctgag gtcaaaaagc ccggatcaag cgtgaaagtc       60

tcatgcaaag ccagcggcta caccttcaca acgtacccta tcgagtgggt gaggcaggct      120

cccggccaag gactggaatg gatggggaac ttccacccat acaacgacga caccaagtac      180

aacgagaagt tcaaggggcg cgttactata accgccgaca agagcactag caccgcctac      240

atggagctga gcagtctgag aagcgaggat acagccgtgt actattgtgc acgggagaat      300

tatggctctc acggcggatt tgtgtactgg ggccaaggaa cactggttac tgtctcgagc      360

gcttctacaa agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      420

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      600

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttggtgag      660

aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagccctc ctgcctggac      720

gcaccccggc tgtgcagccc cagcccaggg cagcaaggca tgccccatct gtctcctcac      780

ccggaggcct ctgaccaccc cactcatgcc cagggagagg gtcttctgga tttttccacc      840

aggctccggg cagccacagg ctggatgccc ctaccccagg ccctgcgcat acaggggcag      900

gtgctgcgct cagacctgcc aagagccata tccgggagga ccctgcccct gacctaagcc      960

caccccaaag gccaaactct ccactccctc agctcagaca ccttctctcc tcccagatct     1020

gagtaactcc caatcttctc tctgcagagt ccaaatatgg tcccccatgc ccaccatgcc     1080

caggtaagcc aacccaggcc tcgccctcca gctcaaggcg ggacaggtgc cctagagtag     1140

cctgcatcca gggacaggcc ccagccgggt gctgacgcat ccacctccat ctcttcctca     1200

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact     1260

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac     1320

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag     1380

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1440

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1500

tccatcgaga aaaccatctc caaagccaaa ggtgggaccc acggggtgcg agggccacat     1560

ggacagaggt cagctcggcc caccctctgc cctgggagtg accgctgtgc caacctctgt     1620

ccctacaggg cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat     1680

gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc     1740

cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct     1800

ggactccgac ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca     1860

ggaggggaat gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca     1920

gaagagcctc tccctgtctc tgggt                                           1945


<210>  78
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  78

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Pro Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230                 235                 240 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly 
465 


<210>  79
<211>  2002
<212>  DNA
<213>  Artificial Sequence

<220>
<223> recombinant

<400>  79
atggagtggt cctgggtgtt tctcttcttt ctctccgtca caacgggtgt tcatagcgaa       60

gtgcagcttg tgcaaagcgg cgctgaggtc aaaaagcccg gatcaagcgt gaaagtctca      120

tgcaaagcca gcggctacac cttcacaacg taccctatcg agtgggtgag gcaggctccc      180

ggccaaggac tggaatggat ggggaacttc cacccataca acgacgacac caagtacaac      240

gagaagttca aggggcgcgt tactataacc gccgacaaga gcactagcac cgcctacatg      300

gagctgagca gtctgagaag cgaggataca gccgtgtact attgtgcacg ggagaattat      360

ggctctcacg gcggatttgt gtactggggc caaggaacac tggttactgt ctcgagcgct      420

tctacaaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      480

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      660

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tggtgagagg      720

ccagcacagg gagggagggt gtctgctgga agccaggctc agccctcctg cctggacgca      780

ccccggctgt gcagccccag cccagggcag caaggcatgc cccatctgtc tcctcacccg      840

gaggcctctg accaccccac tcatgcccag ggagagggtc ttctggattt ttccaccagg      900

ctccgggcag ccacaggctg gatgccccta ccccaggccc tgcgcataca ggggcaggtg      960

ctgcgctcag acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac     1020

cccaaaggcc aaactctcca ctccctcagc tcagacacct tctctcctcc cagatctgag     1080

taactcccaa tcttctctct gcagagtcca aatatggtcc cccatgccca ccatgcccag     1140

gtaagccaac ccaggcctcg ccctccagct caaggcggga caggtgccct agagtagcct     1200

gcatccaggg acaggcccca gccgggtgct gacgcatcca cctccatctc ttcctcagca     1260

cctgagttcc tggggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc     1320

atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc     1380

gaggtccagt tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg     1440

cgggaggagc agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1500

gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc     1560

atcgagaaaa ccatctccaa agccaaaggt gggacccacg gggtgcgagg gccacatgga     1620

cagaggtcag ctcggcccac cctctgccct gggagtgacc gctgtgccaa cctctgtccc     1680

tacagggcag ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac     1740

caagaaccag gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt     1800

ggagtgggag agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga     1860

ctccgacggc tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga     1920

ggggaatgtc ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa     1980

gagcctctcc ctgtctctgg gt                                              2002


<210>  80
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  80

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  81
<211>  1953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant
<400>  81
gaagtgcagc ttgtgcaaag cggcgctgag gtcaaaaagc ccggatcaag cgtgaaagtc       60

tcatgcaaag ccagcggcta caccttcaca acgtacccta tcgagtgggt gaggcaggct      120

cccggccaag gactggaatg gatggggaac ttccacccat acaacgacga caccaagtac      180

aacgagaagt tcaaggggcg cgttactata accgccgaca agagcactag caccgcctac      240

atggagctga gcagtctgag aagcgaggat acagccgtgt actattgtgc acgggagaat      300

tatggctctc acggcggatt tgtgtactgg ggccaaggaa cactggttac tgtctcgagc      360

gcttctacaa agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttggtgag      660

aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagcgctc ctgcctggac      720

gcatcccggc tatgcagccc cagtccaggg cagcaaggca ggccccgtct gcctcttcac      780

ccggaggcct ctgcccgccc cactcatgct cagggagagg gtcttctggc tttttcccca      840

ggctctgggc aggcacaggc taggtgcccc taacccaggc cctgcacaca aaggggcagg      900

tgctgggctc agacctgcca agagccatat ccgggaggac cctgcccctg acctaagccc      960

accccaaagg ccaaactctc cactccctca gctcggacac cttctctcct cccagatctg     1020

agtaactccc aatcttctct ctgcagagcc caaatcttgt gacaaaactc acacatgccc     1080

accgtgccca ggtaagccag cccaggcctc gccctccagc tcaaggcggg acaggtgccc     1140

tagagtagcc tgcatccagg gacaggcccc agccgggtgc tgacacgtcc acctccatct     1200

cttcctcagc acctgaactc ctggggggac cgtcagtctt cctcttcccc ccaaaaccca     1260

aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg gacgtgagcc     1320

acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca     1380

agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg     1440

tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc aacaaagccc     1500

tcccagcccc catcgagaaa accatctcca aagccaaagg tgggacccgt ggggtgcgag     1560

ggccacatgg acagaggccg gctcggccca ccctctgccc tgagagtgac cgctgtacca     1620

acctctgtcc ctacagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1680

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1740

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1800

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1860

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1920

tacacgcaga agagcctctc cctgtctccg ggt                                  1953


<210>  82
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  82

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Pro Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Tyr Gly Ser His Gly Gly Phe Val Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly 
465             


<210>  83
<211>  2010
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  83
atggagtggt cctgggtgtt tctcttcttt ctctccgtca caacgggtgt tcatagcgaa       60

gtgcagcttg tgcaaagcgg cgctgaggtc aaaaagcccg gatcaagcgt gaaagtctca      120

tgcaaagcca gcggctacac cttcacaacg taccctatcg agtgggtgag gcaggctccc      180

ggccaaggac tggaatggat ggggaacttc cacccataca acgacgacac caagtacaac      240

gagaagttca aggggcgcgt tactataacc gccgacaaga gcactagcac cgcctacatg      300

gagctgagca gtctgagaag cgaggataca gccgtgtact attgtgcacg ggagaattat      360

ggctctcacg gcggatttgt gtactggggc caaggaacac tggttactgt ctcgagcgct      420

tctacaaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tggtgagagg      720

ccagcacagg gagggagggt gtctgctgga agccaggctc agcgctcctg cctggacgca      780

tcccggctat gcagccccag tccagggcag caaggcaggc cccgtctgcc tcttcacccg      840

gaggcctctg cccgccccac tcatgctcag ggagagggtc ttctggcttt ttccccaggc      900

tctgggcagg cacaggctag gtgcccctaa cccaggccct gcacacaaag gggcaggtgc      960

tgggctcaga cctgccaaga gccatatccg ggaggaccct gcccctgacc taagcccacc     1020

ccaaaggcca aactctccac tccctcagct cggacacctt ctctcctccc agatctgagt     1080

aactcccaat cttctctctg cagagcccaa atcttgtgac aaaactcaca catgcccacc     1140

gtgcccaggt aagccagccc aggcctcgcc ctccagctca aggcgggaca ggtgccctag     1200

agtagcctgc atccagggac aggccccagc cgggtgctga cacgtccacc tccatctctt     1260

cctcagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg     1320

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg     1380

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga     1440

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc     1500

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc     1560

cagcccccat cgagaaaacc atctccaaag ccaaaggtgg gacccgtggg gtgcgagggc     1620

cacatggaca gaggccggct cggcccaccc tctgccctga gagtgaccgc tgtaccaacc     1680

tctgtcccta cagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1740

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1800

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1860

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1920

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1980

acgcagaaga gcctctccct gtctccgggt                                      2010





