SEQUENCE LISTING





<110> APPLICANT: Bayer Schering Pharma Aktiengesellschaft
<120> TITLE OF INVENTION: Process for the production of radioactively labelled scFv antibody fragments, Kits and Compositions

<141> CURRENT FILING DATE:  
<160> NUMBER OF SEQ ID NO.S: 29
<170> SOFTWARE: PatentIn Ver. 3.3

<210> SEQ ID NO. 1
<211> LENGTH: 116
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: L19 VH region = single chain variable antibody fragment of a monocolonal antibody against the extra domain B of fibronectin
<400> SEQUENCE: 1
      Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
        1                 5                     10                      15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
                     20                     25                      30
      Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                35                      40                     45
      Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val
           50                      55                     60                      
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
       65                     70                      75                      80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                          85                     90                      95
      Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                    100                     105                    110
      Thr Val Ser Ser 
              115



<210> SEQ ID NO. 2
<211> LENGTH: 108
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: L19 VL region = single chain variable antibody fragment of a monocolonal antibody against the extra domain B of fibronectin
<400> SEQUENCE: 2
      Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
       1               5                  10
      Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
      15                   20                  25                  30
      Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                       35                  40                  45
      Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg
                   50                  55                  60        
      Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
               65                  70                  75
      Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg
           80                  85                  90
      Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
       95                 100                 105


<210> SEQ ID NO. 3
<211> LENGTH: 14
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: L19 = single chain variable antibody
      linker fragment of a monocolonal antibody against the
      extra domain B of fibronectin (Site 117..130)
<400> SEQUENCE: 3
Gly Asp Gly Ser Ser Gly Gly Ser Gly Gly Ala Ser Thr Gly 
 1                  5                      10                          



<210> SEQ ID NO. 4
<211> LENGTH: 238
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: L19 = single chain variable antibody
      fragment of a monocolonal antibody against the
      extra domain B of fibronectin
<400> SEQUENCE: 4
      Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
        1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
                   20                  25                  30
      Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
               35                  40                  45
      Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val
           50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
       65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                       85                  90                  95
      Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  100                 105                 110
      Thr Val Ser Ser Gly Asp Gly Ser Ser Gly Gly Ser Gly Gly Ala Ser
              115                 120                 125
      Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
          130                 135                 140
      Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
      145                 150                 155                 160
      Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                      165                 170                 175
      Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg
                  180                 185                 190
      Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
              195                 200                 205
      Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg
          210                 215                 220
      Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
      225                 230                 235



<210> SEQ ID NO 5
<211> LENGTH: 242
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: AP38: labelled derivate of L19
<400> SEQUENCE: 5
      Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
        1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
                   20                  25                  30
      Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
               35                  40                  45
      Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val
           50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
       65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                       85                  90                  95
      Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  100                 105                 110
      Thr Val Ser Ser Gly Asp Gly Ser Ser Gly Gly Ser Gly Gly Ala Ser
              115                 120                 125
      Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
          130                 135                 140
      Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
      145                 150                 155                 160
      Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                      165                 170                 175
      Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg
                  180                 185                 190
      Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
              195                 200                 205
      Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg
          210                 215                 220
      Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly
      225                 230                 235                 240
      Gly Cys

<210> SEQ ID NO 6
<211> LENGTH: 243
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: AP39: labelled derivate of L19
<400> SEQUENCE: 6
      Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
        1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
                   20                  25                  30
      Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
               35                  40                  45
      Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val
           50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
       65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                       85                  90                  95
      Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  100                 105                 110
      Thr Val Ser Ser Gly Asp Gly Ser Ser Gly Gly Ser Gly Gly Ala Ser
              115                 120                 125
      Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
          130                 135                 140
      Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
      145                 150                 155                 160
      Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                      165                 170                 175
      Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg
                  180                 185                 190
      Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
              195                 200                 205
      Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg
          210                 215                 220
      Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly
      225                 230                 235                 240
      Gly Cys Ala



<210> SEQ ID NO 7
<211> LENGTH: 4
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence:antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: amino acid sequence (ba)
<220> FEATURE: 
<221> NAME/KEY: MOD_RES
<222> LOCATION: (1)..(3)
<223> OTHER INFORMATION: Variable amino acid
<400> SEQUENCE: 7
      Xaa Xaa Xaa Cys
        1

<210> SEQ ID NO 8
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: amino acid sequence (bb)
<220> FEATURE: 
<221> NAME/KEY: MOD_RES
<222> LOCATION: (1)..(3)
<223> OTHER INFORMATION: Variable amino acid
<220> FEATURE: 
<221> NAME/KEY: MOD_RES
<222> LOCATION: (5)
<223> OTHER INFORMATION: Variable amino acid
<400> SEQUENCE: 8
      Xaa Xaa Xaa Cys Xaa
        1               5

<210> SEQ ID NO 9
<211> LENGTH: 6
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: amino acid sequence(bc) His = (His)n, wherein n stands for an integer from 4 to 6 
<400> SEQUENCE: 9
      His
        1


<210> SEQ ID NO 10
<211> LENGTH: 4
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: preferred amino acid sequence (ba)
<400> SEQUENCE: 10
      Gly Gly Gly Cys
        1

<210> SEQ ID NO 11
<211> LENGTH: 4
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: preferred amino acid sequence (ba)
<400> SEQUENCE: 11
      Gly Cys Gly Cys
        1

<210> SEQ ID NO 12
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: preferred amino acid sequence (bb)
<400> SEQUENCE: 12
      Gly Gly Gly Cys Ala
        1               5

<210> SEQ ID NO 13
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: preferred amino acid sequence (bb)
<400> SEQUENCE: 13
      Gly Cys Gly Cys Ala
        1               5

<210> SEQ ID NO 14
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: HCDR1 = complementarity determining region of the
      region X of the heavy antibody chain
<400> SEQUENCE: 14
      Ser Phe Ser Met Ser
        1               5


<210> SEQ ID NO. 15
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: HCDR 2 = complementarity determining region of the
      region X of the heavy antibody chain
<400> SEQUENCE: 15
      Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys
        1               5                  10                  15
      Gly

<210> SEQ ID NO. 16
<211> LENGTH: 7
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: HCDR 3 = complementarity determining region of the
      region X of the heavy antibody chain
<400> SEQUENCE: 16
      Pro Phe Pro Tyr Phe Asp Tyr
        1               5

<210> SEQ ID NO. 17
<211> LENGTH: 12
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: LCDR 1 = complementarity determining region of the
      region X of the light antibody chain
<400> SEQUENCE: 17
      Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala
        1               5                  10

<210> SEQ ID NO. 18
<211> LENGTH: 6
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: LCDR 2 = complementarity determining region of the
      region X of the light antibody chain
<400> SEQUENCE: 18
      Tyr Ala Ser Ser Arg Ala
        1               5

<210> SEQ ID NO. 19
<211> LENGTH: 10
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: LCDR 3 = complementarity determining region of the
      region X of the light antibody chain
<400> SEQUENCE: 19
      Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr
        1               5                  10




<210> SEQ ID NO. 20
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: amino acid sequence (bd)
<400> SEQUENCE: 20
      Ala Ala Ala Asp Asp Asp Ser Asp Asp Asp Tyr Lys Asp Asp Asp Asp
        1               5                  10                  15
      Lys

<210> SEQ ID NO. 21
<211> LENGTH: 23
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: amino acid sequence (bd)
<400> SEQUENCE: 21
      Ala Ala Ala Asp Asp Asp Ser Asp Asp Asp Tyr Lys Asp Asp Asp Asp
        1               5                  10                  15
      Lys His His His His His His
                   20

<210> SEQ ID NO. 22
<211> LENGTH: 121
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: amino acid sequence (bd)
<400> SEQUENCE: 22
      Ser Gly Gly Ser Gly Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe
        1               5                  10                  15
      Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys
                   20                  25                  30
      Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu His
               35                  40                  45
      Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg
           50                  55                  60
      Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr
       65                  70                  75                  80
      Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His
                       85                  90                  95
      Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn
                  100                 105                 110
      Pro Glu Ser Ser Arg Arg Gly Gly Cys
              115                 120



<210> SEQ ID NO 23
<211> LENGTH: 22
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: linker amino acid sequence
<400> SEQUENCE: 23
      Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala
        1               5                  10                  15
      Ala Gln Pro Ala Met Ala
                   20



<210> SEQ ID NO 24
<211> LENGTH: 242
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: labelled derivate of L19
<400> SEQUENCE: 24
      Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
        1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
                   20                  25                  30
      Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
               35                  40                  45
      Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val
           50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
       65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                       85                  90                  95
      Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  100                 105                 110
      Thr Val Ser Ser Gly Asp Gly Ser Ser Gly Gly Ser Gly Gly Ala Ser
              115                 120                 125
      Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
          130                 135                 140
      Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
      145                 150                 155                 160
      Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                      165                 170                 175
      Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg
                  180                 185                 190
      Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
              195                 200                 205
      Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg
          210                 215                 220
      Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Cys
      225                 230                 235                 240
      Gly Cys

<210> SEQ ID NO 25
<211> LENGTH: 243
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: labelled derivate of L19
<400> SEQUENCE: 25
      Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
        1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
                   20                  25                  30
      Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
               35                  40                  45
      Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val
           50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
       65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                       85                  90                  95
      Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  100                 105                 110
      Thr Val Ser Ser Gly Asp Gly Ser Ser Gly Gly Ser Gly Gly Ala Ser
              115                 120                 125
      Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
          130                 135                 140
      Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
      145                 150                 155                 160
      Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                      165                 170                 175
      Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg
                  180                 185                 190
      Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
              195                 200                 205
      Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg
          210                 215                 220
      Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Cys
      225                 230                 235                 240
      Gly Cys Ala


<210> SEQ ID NO 26
<211> LENGTH: 283
<212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: 
<223> OTHER INFORMATION: Description of Artificial Sequence: antibody or
      antibody fragment
<220> FEATURE: 
<223> OTHER INFORMATION: ZK225293: labelled derivate of L19
<400> SEQUENCE: 26
      Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala
        1               5                  10                  15
      Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly
                   20                  25                  30
      Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
               35                  40                  45
      Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly
           50                  55                  60
      Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr
       65                  70                  75                  80
      Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                       85                  90                  95
      Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  100                 105                 110
      Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp
              115                 120                 125
      Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Asp Gly Ser Ser Gly
          130                 135                 140
      Gly Ser Gly Gly Ala Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro
      145                 150                 155                 160
      Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg
                      165                 170                 175
      Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys
                  180                 185                 190
      Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala
              195                 200                 205
      Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
          210                 215                 220
      Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
      225                 230                 235                 240
      Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys
                      245                 250                 255
      Val Glu Ile Lys Ala Ala Ala Asp Asp Asp Ser Asp Asp Asp Tyr Lys
                  260                 265                 270
      Asp Asp Asp Asp Lys His His His His His His
              275                 280


