                         SEQUENCE LISTING

<110>  NOX Technologies, Inc.
       Morre, D. James
       Tang, Xiaoyu
 
<120>  NEOPLASIA-SPECIFIC AUTOANTIBODIES AND METHODS

<130>  106-10 WO

<140>  unassigned
<141>  2011-03-03

<150>  US 61/310,113
<151>  2010-03-03

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic constuct:  sequence encoding peptide linker

<400>  1
ggaggcggtg gatcgggcgg tggcggctcg ggtggcggcg gctct                       45


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  linker peptide

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  3
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  sequence encoding S tag

<400>  3
aaagaaaccg ctgctgctaa attcgaacgc cagcacatgg acagc                       45


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  S tag

<400>  4

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  5
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  sequence encoding single chain antibody

<400>  5
atggctagca atcagccggc agaggtgcag ctggtggagt ctggggctga ggtgaagaag       60

cctggggcct cagtgaaggt ttcctgcaag gcttctggat acaccttcac tagctatgct      120

atgcattggg tgcgccaggc ccccggacaa aggcttgagt ggatgggatg gatcagcgct      180

tacaatggta acacaaacta tgcacagaag ctccagggca gagtcaccat gaccacagtc      240

acatccacga gcacagccta catggagctg aggagcctga gatctgacgg cacggccgtg      300

tattactgtg cgagagatct gctagtgggc ctcggctact ggggccaggg aaccctggtc      360

accgtctcct cagggagtgc atccgcccca acccttttcc ccctcgtctc ctgtgagaat      420

tccccgtcgg atacgagcag cgtggccgtt ggctgcctcg cacaggactt ccttcccgac      480

tccatcactt tcggaggcgg tggatcgggc ggtggcggct cgggtggcgg cggctctgaa      540

atagtattga cacagtctcc agccaccctg tctgtgtctc caggggaaag agccaccctc      600

tcctgcaggg ccagtcagag tgttagcagc cacttagcct ggtaccaaca gaaacctggc      660

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagacagg      720

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagact ggagcctgaa      780

gattttgcag tgtattactg tcagcagtat ggtagctcac ctccgtacac tttcggccct      840

gggaccaaag tggatatcaa acgaactgtg gctgcaccat ctgtcttcat caaagaaacc      900

gcagctgcta aattcgaacg ccagcacatg gacagttaa                             939


<210>  6
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  single chain antibody

<400>  6

Met Ala Ser Asn Gln Pro Ala Glu Val Gln Leu Val Glu Ser Gly Ala 
1               5                   10                  15      


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25                  30          


Gly Tyr Thr Phe Thr Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro 
        35                  40                  45              


Gly Gln Arg Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn 
    50                  55                  60                  


Thr Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Val 
65                  70                  75                  80  


Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp 
                85                  90                  95      


Gly Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Leu Val Gly Leu Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn Ser Pro Ser Asp 
    130                 135                 140                 


Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp Phe Leu Pro Asp 
145                 150                 155                 160 


Ser Ile Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val 
            180                 185                 190         


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        195                 200                 205             


Ser Ser His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    210                 215                 220                 


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg 
225                 230                 235                 240 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                245                 250                 255     


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
            260                 265                 270         


Ser Pro Pro Tyr Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        275                 280                 285             


Thr Val Ala Ala Pro Ser Val Phe Ile Lys Glu Thr Ala Ala Ala Lys 
    290                 295                 300                 


Phe Glu Arg Gln His Met Asp Ser 
305                 310         


<210>  7
<211>  2108
<212>  DNA
<213>  Homo sapiens

<400>  7
ttttgtttaa ctttaagaag gagatataca tatggctagc aatcagccgg cagaggtgca       60

gctggtggag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg tttcctgcaa      120

ggcttctgga tacaccttca ctagctatgc tatgcattgg gtgcgccagg cccccggaca      180

aaggcttgag tggatgggat ggatcagcgc ttacaatggt aacacaaact atgcacagaa      240

gctccagggc agagtcacca tgaccacagt cacatccacg agcacagcct acatggagct      300

gaggagcctg agatctgacg gcacggccgt gtattactgt gcgagagatc tgctagtggg      360

cctcggctac tggggccagg gaaccctggt caccgtctcc tcagggagtg catccgcccc      420

aacccttttc cccctcgtct cctgtgagaa ttccccgtcg gatacgagca gcgtggccgt      480

tggctgcctc gcacaggact tccttcccga ctccatcact ttctcctgga aatacaagaa      540

caactctgac atcagcagca cccggggctt cccatcagtc ctgagagggg gcaagtacgc      600

agccacctca caggtgctgc tgccttccaa ggacgtcatg cagggcacag acgaacacgt      660

ggtgtgcaaa gtccagcacc ccaacggcaa caaagaaaag aacgtgcctc ttccagtgat      720

tgctgagctg cctcccaaag tgagcgtctt cgtcccaccc cgcgacggct tcttcggcaa      780

cccccgcagc aagtccaagc tcatctgcca ggccacgggt ttcagtcccc ggcagattca      840

ggtgtcctgg ctgcgcgagg ggaagcaggt ggggtctggc gtcaccacgg accaggtgca      900

ggctgaggcc aaagagtctg ggcccacgac ctacaaggtg accagcacac tgaccatcaa      960

agagagcgac tggctcagcc agagcatgtt cacctgccgc gtggatcaca ggggcctgac     1020

cttccagcag aatgcgtcct ccatgtgtgt ccccgatcaa gacacagcca tccgggtctt     1080

cgccatcccc ccatcctttg ccagcatctt cctcaccaag tccaccaagt tgacctgcct     1140

ggtcacagac ctgaccacct atgacagcgt gaccatctcc tggacccgcc agaatggcga     1200

agctgtgaaa acccacacca acatctccga gagccacccc aatgccactt tcagcgccgt     1260

gggtgaggcc agcatctgcg aggatgactg gaattccggg gagaggttca cgtgcaccgt     1320

gacccacaca gacctgccct cgccactgaa gcagaccatc tcccggccca agggggtggc     1380

cctgcacagg cccgatgtct acttgctgcc accagcccgg gagcagctga acctgcggga     1440

gtcggccacc atcacgtgcc tggtgacggg cttctctccc gcggacgtct tcgtgcagtg     1500

gatgcagagg gggcagccct tgtccccgga gaagtatgtg accagcgccc caatgcctga     1560

gccccaggcc ccaggccggt acttcgccca cagcatcctg accgtgtccg aagaggaatg     1620

gaacacgggg gagacctaca cctgcgtggt ggcccatgag gccctgccca acagggtcac     1680

cgagaggacc gtggacaagt ccaccgaggg ggaggtgagc gccgacgagg agggctttga     1740

gaacctgtgg gccaccgcct ccaccttcat cgtcctcttc ctcctgagcc tcttctacag     1800

taccaccgtc accttgttca aggtgaaatg atcccaacag aagaacatcg gagaccagag     1860

agaggaactc aaaggggcgc tgcctccggg tctggggtcc tggcctgcgt ggcctgttgg     1920

cacgtgtttc tcttcccgcc cggcctccag ttgtgtgctc tcacacaggc ttccttctcg     1980

accggcaggg gctggctggc ttgcaggcca cgaggtgggc tctaccccac actgctttgc     2040

tgtgtatacg cttgttgccc tgaaataaat atgcacattt tatccatgaa aaaaaaaaaa     2100

aaaaaaaa                                                              2108


<210>  8
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ser Asn Gln Pro Ala Glu Val Gln Leu Val Glu Ser Gly Ala 
1               5                   10                  15      


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25                  30          


Gly Tyr Thr Phe Thr Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro 
        35                  40                  45              


Gly Gln Arg Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn 
    50                  55                  60                  


Thr Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Val 
65                  70                  75                  80  


Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp 
                85                  90                  95      


Gly Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Leu Val Gly Leu Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn Ser Pro Ser Asp 
    130                 135                 140                 


Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp Phe Leu Pro Asp 
145                 150                 155                 160 


Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser Asp Ile Ser Ser 
                165                 170                 175     


Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys Tyr Ala Ala Thr 
            180                 185                 190         


Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln Gly Thr Asp Glu 
        195                 200                 205             


His Val Val Cys Lys Val Gln His Pro Asn Gly Asn Lys Glu Lys Asn 
    210                 215                 220                 


Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe 
225                 230                 235                 240 


Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Ser Lys Ser Lys 
                245                 250                 255     


Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser 
            260                 265                 270         


Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln 
        275                 280                 285             


Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr 
    290                 295                 300                 


Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln Ser Met Phe 
305                 310                 315                 320 


Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser 
                325                 330                 335     


Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile 
            340                 345                 350         


Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr 
        355                 360                 365             


Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp 
    370                 375                 380                 


Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu 
385                 390                 395                 400 


Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys 
                405                 410                 415     


Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His 
            420                 425                 430         


Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly 
        435                 440                 445             


Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu 
    450                 455                 460                 


Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly 
465                 470                 475                 480 


Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro 
                485                 490                 495     


Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln 
            500                 505                 510         


Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu 
        515                 520                 525             


Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu Ala 
    530                 535                 540                 


Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Glu Gly 
545                 550                 555                 560 


Glu Val Ser Ala Asp Glu Glu Gly Phe Glu Asn Leu Trp Ala Thr Ala 
                565                 570                 575     


Ser Thr Phe Ile Val Leu Phe Leu Leu Ser Leu Phe Tyr Ser Thr Thr 
            580                 585                 590         


Val Thr Leu Phe Lys Val Lys 
        595                 


<210>  9
<211>  836
<212>  DNA
<213>  Homo sapiens

<400>  9
tcaggacaca gcatggacat gagggtcccc gctcagctcc tggggctcct gctgctctgg       60

ttcccaggtt ccagatgcga catccaggaa atagtattga cacagtctcc agccaccctg      120

tctgtgtctc caggggaaag agccaccctc tcctgcaggg ccagtcagag tgttagcagc      180

cacttagcct ggtaccaaca gaaacctggc caggctccca ggctcctcat ctatgatgca      240

tccaacaggg ccactggcat cccagacagg ttcagtggca gtgggtctgg gacagacttc      300

actctcacca tcagcagact ggagcctgaa gattttgcag tgtattactg tcagcagtat      360

ggtagctcac ctccgtacac tttcggccct gggaccaaag tggatatcaa acgaactgtg      420

gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc      480

tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg      540

gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac      600

agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa      660

ctctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac      720

aggggagagt gttagaggga gaagtgcccc cacctgctcc tcagttccag cctgaccccc      780

tcccatcctt tggcctctga ccctttttcc acaggggacc tacccctatt gcggtc          836


<210>  10
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Gln Glu Ile Val Leu Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Ser Val Ser Ser His Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala 
65                  70                  75                  80  


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Gly Ser Ser Pro Pro Tyr Thr Phe Gly Pro Gly Thr 
        115                 120                 125             


Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Leu Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  Strep tag sequence

<400>  11

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  FLAG tag sequence

<400>  12

Asn Asp Tyr Lys Asp Asp Asp Asp Lys Cys 
1               5                   10  


<210>  13
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  tandem repeat of single chain antibody with
       intervening linker peptide sequence

<400>  13

Met Ala Ser Asn Gln Pro Ala Glu Val Gln Leu Val Glu Ser Gly Ala 
1               5                   10                  15      


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25                  30          


Gly Tyr Thr Phe Thr Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro 
        35                  40                  45              


Gly Gln Arg Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn 
    50                  55                  60                  


Thr Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Val 
65                  70                  75                  80  


Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp 
                85                  90                  95      


Gly Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Leu Val Gly Leu Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn Ser Pro Ser Asp 
    130                 135                 140                 


Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp Phe Leu Pro Asp 
145                 150                 155                 160 


Ser Ile Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val 
            180                 185                 190         


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        195                 200                 205             


Ser Ser His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    210                 215                 220                 


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg 
225                 230                 235                 240 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                245                 250                 255     


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
            260                 265                 270         


Ser Pro Pro Tyr Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        275                 280                 285             


Thr Val Ala Ala Pro Ser Val Phe Ile Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala Ser 
305                 310                 315                 320 


Asn Gln Pro Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys 
                325                 330                 335     


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
            340                 345                 350         


Phe Thr Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg 
        355                 360                 365             


Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr 
    370                 375                 380                 


Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Val Thr Ser Thr 
385                 390                 395                 400 


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Gly Thr Ala 
                405                 410                 415     


Val Tyr Tyr Cys Ala Arg Asp Leu Leu Val Gly Leu Gly Tyr Trp Gly 
            420                 425                 430         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Thr 
        435                 440                 445             


Leu Phe Pro Leu Val Ser Cys Glu Asn Ser Pro Ser Asp Thr Ser Ser 
    450                 455                 460                 


Val Ala Val Gly Cys Leu Ala Gln Asp Phe Leu Pro Asp Ser Ile Thr 
465                 470                 475                 480 


Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
            500                 505                 510         


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser His 
        515                 520                 525             


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
    530                 535                 540                 


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
545                 550                 555                 560 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
                565                 570                 575     


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro 
            580                 585                 590         


Tyr Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala 
        595                 600                 605             


Ala Pro Ser Val Phe Ile Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg 
    610                 615                 620                 


Gln His Met Asp Ser 
625                 


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  14
saggtgmagy tgktggagtc tgg                                               23


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  15
aagtgatgga gtcgggaagg aagt                                              24


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  16
gaaatwgtrw tgacrcagtc tcca                                              24


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  17
gatgaagaca gatggtgcag ccac                                              24


<210>  18
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  18
atatcagccg gccsaggtgm agytgktg                                          28


<210>  19
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  19
agagccgccg ccacccgagc cgccaccgcc cgatccaccg cctccgaaag tgatggagtc       60

gg                                                                      62


<210>  20
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  20
ggaggcggtg gatcgggcgg tggcggctcg ggtggcggcg gctctgaaat wgtrwtgacr       60

cagtctcca                                                               69


<210>  21
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  21
agcggccgcg atgaagacag atggtgcagc cac                                    33


<210>  22
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  22
catatacata tggctagcaa tcagccggcc saggt                                  35


<210>  23
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  primer

<400>  23
tagcatccgg atccttaact gtccatgtgc tggcgttcga atttagcagc tgcggtttct       60

ttgatgaaga cagatggtgc                                                   80


