                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
       Garcia, Joe G. N.
       Dudek, Steven M.
 
<120>  METHOD OF TREATING ACUTE LUNG INJURY USING 
       SPHINGOSINE 1 PHOSPHATE ANALOGS or SPHINGOSINE 1 PHOSPHATE
       RECEPTOR AGONISTS

<130>  11-340-WO

<150>  US 61/309,948
<151>  2010-02-03

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  2860
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (104)..(997)

<400>  1
actcggcctc taagctcctg gagttgctgc gtccgcgcag tccggaactg cggtgtggcc       60

ccagccggga cagagagggt ccgtcgtaac ctgttgagta act atg gaa gac tat        115
                                                Met Glu Asp Tyr           
                                                1                         

atc aaa ata gag aaa att gga gaa ggt act tac ggt gtg gtg tat aag        163
Ile Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly Val Val Tyr Lys           
5                   10                  15                  20            

ggt aga cac aga gtc act ggc cag ata gtg gcc atg aag aag atc aga        211
Gly Arg His Arg Val Thr Gly Gln Ile Val Ala Met Lys Lys Ile Arg           
                25                  30                  35                

ctt gaa agc gag gaa gaa gga gtg ccc agt act gca att cgg gaa atc        259
Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala Ile Arg Glu Ile           
            40                  45                  50                    

tct cta tta aaa gaa ctt cga cat cca aat ata gtc agc ctg cag gat        307
Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val Ser Leu Gln Asp           
        55                  60                  65                        

gtg ctc atg cag gac tcc agg ctg tat ctc atc ttt gag ttc ctg tcc        355
Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe Glu Phe Leu Ser           
    70                  75                  80                            

atg gac ctc aag aag tac ctg gac tcc atc cct cct ggg cag ttc atg        403
Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro Gly Gln Phe Met           
85                  90                  95                  100           

gat tct tca ctc gtt aag agt tac tta cac caa atc ctc cag gga att        451
Asp Ser Ser Leu Val Lys Ser Tyr Leu His Gln Ile Leu Gln Gly Ile           
                105                 110                 115               

gtg ttt tgc cac tcc cgg cga gtt ctt cac aga gac ttg aaa cct caa        499
Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp Leu Lys Pro Gln           
            120                 125                 130                   

aat cta ttg att gat gac aaa gga aca atc aaa ctg gct gat ttc ggc        547
Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu Ala Asp Phe Gly           
        135                 140                 145                       

ctt gcc aga gcg ttt gga ata ccg ata cga gtg tac aca cac gag gta        595
Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr Thr His Glu Val           
    150                 155                 160                           

gtg acg ctg tgg tac cga tct cca gaa gtg ttg ctg ggc tcg gct cgt        643
Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu Gly Ser Ala Arg           
165                 170                 175                 180           

tac tcc act ccg gtt gac atc tgg agt ata ggg acc ata ttt gca gaa        691
Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr Ile Phe Ala Glu           
                185                 190                 195               

ctg gcc acc aag aag ccg ctt ttc cac ggc gac tca gag att gac cag        739
Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser Glu Ile Asp Gln           
            200                 205                 210                   

ctc ttc agg atc ttc aga gct ctg ggc act cct aac aac gaa gtg tgg        787
Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn Asn Glu Val Trp           
        215                 220                 225                       

cca gaa gtc gag tcc ctg cag gac tac aag aac acc ttt ccc aag tgg        835
Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr Phe Pro Lys Trp           
    230                 235                 240                           

aag ccg ggg agc ctc gca tcc cac gtc aag aac ctg gac gag aac ggc        883
Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu Asp Glu Asn Gly           
245                 250                 255                 260           

ttg gat ttg ctc tca aaa atg cta gtc tat gat cct gcc aaa cga atc        931
Leu Asp Leu Leu Ser Lys Met Leu Val Tyr Asp Pro Ala Lys Arg Ile           
                265                 270                 275               

tct ggc aaa atg gcc ctg aag cac ccg tac ttt gat gac ttg gac aat        979
Ser Gly Lys Met Ala Leu Lys His Pro Tyr Phe Asp Asp Leu Asp Asn           
            280                 285                 290                   

cag att aag aag atg tag ccctctggat ggatgtccct gtctgctggt              1027
Gln Ile Lys Lys Met                                                       
        295                                                               

cgtaggggaa gatcgtgttg tttaccgttg gctctcttcc tgtcttgtat agttttcttt     1087

gtttgtaaac tgtcatctgg acttttctta atttcctacg tataacttaa ttaacatgta     1147

aatattattc catatgaatt taaatataat tctgtatatg tgcagatgtc actgtggtgg     1207

ctgttaatta ctataacaca agtgttaatt actacaacat aagacttgag tctccctaga     1267

cttcccagca gccattcctg cagctcggag cacagttgaa ggagctgagc tcaggcctcg     1327

tgatgctttc aagtgcctcc gtgttctgga tatatatgat tcctggtcag tttcttgcca     1387

tttggaaact acaacccacc tacggacagt gtttttctac ttgtgcttaa gcagttggga     1447

tgagaaggcc aaagacccga ggatgtctag agtaatgacc cccagatgga agtgcaccaa     1507

agctggctgg gtttcacagc tagagatcag gggctgtcca gagcaggaca gcttagaaca     1567

tttatgaaga ctccctattt ttaggtttgt tgtaaagctg ttgtctagtt ggattcctgt     1627

gctctgcatg gtcagaggta ggttagagga tttgccttgg cttctaaatc caatttgaaa     1687

actgcttaaa atctcctgtc ctctcttagc agtgtctaaa aatgtccttg tccaaatatt     1747

tagctgagat tcctcacttt ggaaaaggag ccgtatcgct gtgctgctta gtgtaattct     1807

tagaagcagc ctgacttatc tgctagcagt caaagggatg cctgagacga ctgctcctct     1867

tagaactaaa ggctgggatg cttaagtttg tctactgttt ggaggatctc ggtaagactg     1927

agcccctgtt cctgtggcca cctcagttta ccagtacctc agcctcagcc tcctgcattt     1987

gctggagtca gggaaggtcc ccagccctga gccctgacgc tcctgattgt agagactgtc     2047

agttggaggt aaaacgttca ttgaagtagt cagcagccac atgcatttag ggcactccag     2107

tgtcagagac catcctggag gtttctaacc ctgccgctgg cagtctactc ccaagacaga     2167

tcagttagag tggtcagcaa acaccaactg ctgcagaaac ctgtgttggt gtggttccct     2227

gctgctgctg ggaactgggc ccaagactag agagcttggg gctgcggttg atcatgggtt     2287

ctgttcctgc attacacctt gaaatccaag ccttctaata tctcccttcg gatcataagt     2347

tgtgaatttg gtcctccgcc cccgccaggt tttctatact tgggtttgtc ttgctgacat     2407

tttcaagagt cctgactaag acggtgatta gtgtgacatg acttgagaac taccgatttg     2467

aagcacactt gaagttaaca aattctctca tgattatact tttaactttt tataagattg     2527

cttgagctca cccagatctc tgttgggaag taactgggta acaaaagccg ttgcactggt     2587

ttgacagcta acaactgttg gtactttgta ttcagaagga atgaggtagc gattgaatgg     2647

ctggggtgtt gtttccacag tttatacact aaaaatttgg gtagccagga ggtagtggcg     2707

cgcaatcttt aatctcagca gaggcagtcc tatctcttga gttggaggcc agcctgcctg     2767

agttccagac cagccagggc tacaggaaga agtcttaaaa aaattttttt tccctgtgga     2827

tgtaaaccca tgagaatgac tgctgtatct atc                                  2860


<210>  2
<211>  297
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Asp Tyr Ile Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Arg Val Thr Gly Gln Ile Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Phe Met Asp Ser Ser Leu Val Lys Ser Tyr Leu His Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Val Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Lys His Pro Tyr Phe Asp 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210>  3
<211>  1923
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (143)..(1036)

<400>  3
agcgcggtga gtttgaaact gctcgcactt ggcttcaaag ctggctcttg gaaattgagc       60

ggagagcgac gcggttgttg tagctgccgc tgcggccgcc gcggaataat aagccgggat      120

ctaccatacc cattgactaa ct atg gaa gat tat acc aaa ata gag aaa att       172
                         Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile          
                         1               5                   10           

gga gaa ggt acc tat gga gtt gtg tat aag ggt aga cac aaa act aca        220
Gly Glu Gly Thr Tyr Gly Val Val Tyr Lys Gly Arg His Lys Thr Thr           
                15                  20                  25                

ggt caa gtg gta gcc atg aaa aaa atc aga cta gaa agt gaa gag gaa        268
Gly Gln Val Val Ala Met Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu           
            30                  35                  40                    

ggg gtt cct agt act gca att cgg gaa att tct cta tta aag gaa ctt        316
Gly Val Pro Ser Thr Ala Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu           
        45                  50                  55                        

cgt cat cca aat ata gtc agt ctt cag gat gtg ctt atg cag gat tcc        364
Arg His Pro Asn Ile Val Ser Leu Gln Asp Val Leu Met Gln Asp Ser           
    60                  65                  70                            

agg tta tat ctc atc ttt gag ttt ctt tcc atg gat ctg aag aaa tac        412
Arg Leu Tyr Leu Ile Phe Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr           
75                  80                  85                  90            

ttg gat tct atc cct cct ggt cag tac atg gat tct tca ctt gtt aag        460
Leu Asp Ser Ile Pro Pro Gly Gln Tyr Met Asp Ser Ser Leu Val Lys           
                95                  100                 105               

agt tat tta tac caa atc cta cag ggg att gtg ttt tgt cac tct aga        508
Ser Tyr Leu Tyr Gln Ile Leu Gln Gly Ile Val Phe Cys His Ser Arg           
            110                 115                 120                   

aga gtt ctt cac aga gac tta aaa cct caa aat ctc ttg att gat gac        556
Arg Val Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp           
        125                 130                 135                       

aaa gga aca att aaa ctg gct gat ttt ggc ctt gcc aga gct ttt gga        604
Lys Gly Thr Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly           
    140                 145                 150                           

ata cct atc aga gta tat aca cat gag gta gta aca ctc tgg tac aga        652
Ile Pro Ile Arg Val Tyr Thr His Glu Val Val Thr Leu Trp Tyr Arg           
155                 160                 165                 170           

tct cca gaa gta ttg ctg ggg tca gct cgt tac tca act cca gtt gac        700
Ser Pro Glu Val Leu Leu Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp           
                175                 180                 185               

att tgg agt ata ggc acc ata ttt gct gaa cta gca act aag aaa cca        748
Ile Trp Ser Ile Gly Thr Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro           
            190                 195                 200                   

ctt ttc cat ggg gat tca gaa att gat caa ctc ttc agg att ttc aga        796
Leu Phe His Gly Asp Ser Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg           
        205                 210                 215                       

gct ttg ggc act ccc aat aat gaa gtg tgg cca gaa gtg gaa tct tta        844
Ala Leu Gly Thr Pro Asn Asn Glu Val Trp Pro Glu Val Glu Ser Leu           
    220                 225                 230                           

cag gac tat aag aat aca ttt ccc aaa tgg aaa cca gga agc cta gca        892
Gln Asp Tyr Lys Asn Thr Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala           
235                 240                 245                 250           

tcc cat gtc aaa aac ttg gat gaa aat ggc ttg gat ttg ctc tcg aaa        940
Ser His Val Lys Asn Leu Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys           
                255                 260                 265               

atg tta atc tat gat cca gcc aaa cga att tct ggc aaa atg gca ctg        988
Met Leu Ile Tyr Asp Pro Ala Lys Arg Ile Ser Gly Lys Met Ala Leu           
            270                 275                 280                   

aat cat cca tat ttt aat gat ttg gac aat cag att aag aag atg tag       1036
Asn His Pro Tyr Phe Asn Asp Leu Asp Asn Gln Ile Lys Lys Met               
        285                 290                 295                       

ctttctgaca aaaagtttcc atatgttata tcaacagata gttgtgtttt tattgttaac     1096

tcttgtctat ttttgtctta tatatatttc tttgttatca aacttcagct gtacttcgtc     1156

ttctaatttc aaaaatataa cttaaaaatg taaatattct atatgaattt aaatataatt     1216

ctgtaaatgt gtgtaggtct cactgtaaca actatttgtt actataataa aactataata     1276

ttgatgtcag gaatcaggaa aaaatttgag ttggcttaaa tcatctcagt ccttatggca     1336

gttttatttt cctgtagttg gaactactaa aatttaggaa aatgctaagt tcaagtttcg     1396

taatgctttg aagtattttt atgctctgaa tgtttaaatg ttctcatcag tttcttgcca     1456

tgttgttaac tatacaacct ggctaaagat gaatattttt ctactggtat tttaattttt     1516

gacctaaatg tttaagcatt cggaatgaga aaactataca gatttgagaa atgatgctaa     1576

atttatagga gttttcagta acttaaaaag ctaacatgag agcatgccaa aatttgctaa     1636

gtcttacaaa gatcaagggc tgtccgcaac agggaagaac agttttgaaa atttatgaac     1696

tatcttattt ttaggtaggt tttgaaagct ttttgtctaa gtgaattctt atgccttggt     1756

cagagtaata actgaaggag ttgcttatct tggctttcga gtctgagttt aaaactacac     1816

attttgacat agtgtttatt agcagccatc taaaaaggct ctaatgtata tttaactaaa     1876

attactagct ttgggaatta aactgtttaa caaataaaaa aaaaaaa                   1923


<210>  4
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210>  5
<211>  2827
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (174)..(1442)

<400>  5
ttgaactaca agaccagcag ccggcgggcg gcgcgcagct cgcggctcct gggctctacg       60

ctcctcccgc ctgcagcctc tgctccgcgg gtcggccgcc agggtcccgc gctgctccgg      120

agcggcgggc gctgtgcacg ctctgccgcc gacagaaccg gaccggagcc gcg atg         176
                                                           Met            
                                                           1              

ccg ggc acc tcg agg cat tcg ggt cgc gat gcg ggc tca gcc ctg ctc        224
Pro Gly Thr Ser Arg His Ser Gly Arg Asp Ala Gly Ser Ala Leu Leu           
            5                   10                  15                    

tcg ctg cat cag gaa gac caa gag aat gtc aac ccc gaa aaa ctg gcg        272
Ser Leu His Gln Glu Asp Gln Glu Asn Val Asn Pro Glu Lys Leu Ala           
        20                  25                  30                        

cca gcc cag cag ccg cgg gcg cag gcg gtg ctg aag gcc ggg aac gtg        320
Pro Ala Gln Gln Pro Arg Ala Gln Ala Val Leu Lys Ala Gly Asn Val           
    35                  40                  45                            

cgt gga ccc gcg ccg cag cag aag ctc aag act cga cgg gtt gct cct        368
Arg Gly Pro Ala Pro Gln Gln Lys Leu Lys Thr Arg Arg Val Ala Pro           
50                  55                  60                  65            

ctt aag gac ctt cct ata aac gat gag cat gtc act gct ggt cct tca        416
Leu Lys Asp Leu Pro Ile Asn Asp Glu His Val Thr Ala Gly Pro Ser           
                70                  75                  80                

tgg aaa gca gtc agt aaa cag cct gcc ttc acc att cat gtg gat gaa        464
Trp Lys Ala Val Ser Lys Gln Pro Ala Phe Thr Ile His Val Asp Glu           
            85                  90                  95                    

gca gaa gag act cag aag agg cca gct gag ctt aaa gaa aca gag tgt        512
Ala Glu Glu Thr Gln Lys Arg Pro Ala Glu Leu Lys Glu Thr Glu Cys           
        100                 105                 110                       

gaa gat gcc ctg gct ttt aat gca gct gtc tct tta ccc gga gca aga        560
Glu Asp Ala Leu Ala Phe Asn Ala Ala Val Ser Leu Pro Gly Ala Arg           
    115                 120                 125                           

aaa cca ctg aca cct ctt gac tat cca atg gat ggc agt ttt gaa tca        608
Lys Pro Leu Thr Pro Leu Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser           
130                 135                 140                 145           

cca cat gct atg gat atg tct att gtc tta gaa gac aag cca gtg aac        656
Pro His Ala Met Asp Met Ser Ile Val Leu Glu Asp Lys Pro Val Asn           
                150                 155                 160               

gtt aat gaa gta cct gac tat caa gaa gac att cac acg tac ctt agg        704
Val Asn Glu Val Pro Asp Tyr Gln Glu Asp Ile His Thr Tyr Leu Arg           
            165                 170                 175                   

gaa atg gag gtt aaa tgt aaa cct aaa gtg ggt tac atg aag agg cag        752
Glu Met Glu Val Lys Cys Lys Pro Lys Val Gly Tyr Met Lys Arg Gln           
        180                 185                 190                       

cca gac atc act aac agc atg agg gcc atc ctt gtg gac tgg ctg gtt        800
Pro Asp Ile Thr Asn Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val           
    195                 200                 205                           

gag gtg gga gaa gaa tat aaa cta cag aat gag acc ctg cat ttg gct        848
Glu Val Gly Glu Glu Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala           
210                 215                 220                 225           

gtg aac tac att gat aga ttc ctc tcc tcc atg tct gtg tta aga ggg        896
Val Asn Tyr Ile Asp Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly           
                230                 235                 240               

aag ctt cag ctt gta ggc acg gct gct atg ctg cta gct tcg aag ttt        944
Lys Leu Gln Leu Val Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Phe           
            245                 250                 255                   

gaa gaa ata tac ccc cca gaa gta gca gag ttt gtg tat att aca gac        992
Glu Glu Ile Tyr Pro Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp           
        260                 265                 270                       

gat acc tat tcc aag aag cag gtt ctg aga atg gag cac cta gta ttg       1040
Asp Thr Tyr Ser Lys Lys Gln Val Leu Arg Met Glu His Leu Val Leu           
    275                 280                 285                           

aaa gtc ctt gct ttt gac ttg gct gca cca aca gta aat cag ttc ctt       1088
Lys Val Leu Ala Phe Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu           
290                 295                 300                 305           

acc cag tac ttc ctg cac ctg cag cct gca aac tgt aag gtt gaa agc       1136
Thr Gln Tyr Phe Leu His Leu Gln Pro Ala Asn Cys Lys Val Glu Ser           
                310                 315                 320               

tta gca atg ttt ttg gga gaa ctg agt ttg ata gat gct gac ccg tac       1184
Leu Ala Met Phe Leu Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr           
            325                 330                 335                   

ctt aag tac ctg cct tca ctc att gct gga gct gcc ttc cac ttg gct       1232
Leu Lys Tyr Leu Pro Ser Leu Ile Ala Gly Ala Ala Phe His Leu Ala           
        340                 345                 350                       

ctc tac aca gtc aca gga cag agc tgg cct gag tca ttg gca caa cag       1280
Leu Tyr Thr Val Thr Gly Gln Ser Trp Pro Glu Ser Leu Ala Gln Gln           
    355                 360                 365                           

act gga tat acc ctg gag agt ctt aag cct tgt ctt gtg gac ctt cac       1328
Thr Gly Tyr Thr Leu Glu Ser Leu Lys Pro Cys Leu Val Asp Leu His           
370                 375                 380                 385           

cag acc tac ctc aaa gcg cca caa cat gcc caa cag tca ata cgg gaa       1376
Gln Thr Tyr Leu Lys Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu           
                390                 395                 400               

aag tac aag cat tca aaa tat cac agt gtt tct ctt ctc aac cca cca       1424
Lys Tyr Lys His Ser Lys Tyr His Ser Val Ser Leu Leu Asn Pro Pro           
            405                 410                 415                   

gag aca cta agt gtg tga gtgaaagact gccggctttg tttgaaacag              1472
Glu Thr Leu Ser Val                                                       
        420                                                               

gagtcgctcg gagtccatgc tgtacagttt ttatgtcggg ttttagtttc acaatcactt     1532

ctgaatgtag atggtatagc cacagacaaa ttatggtatc cattgctttt aaaatggttt     1592

taatttgtat atcttttgta catgtgtcta tttggataat tttaattggt taacattggt     1652

gctgccaact gtcaagatat tgagaataaa ctgatttgga aatctttgca agtcaaagtt     1712

aatctgagat aaaaatatga atgatgtcgt ttagaaacta acttgatttg ttttattgta     1772

cagtggggag taggaaaaga ttttataaaa ctaaaatatt tcagggaaaa agaccttcaa     1832

attctggcat tgattgatta ttctaagcaa ccaaaccaaa ctgctgactt gttcataaat     1892

aaccaaaagt agacaaactg ttttcaatgt agcagaactc attcggctct cagatgttac     1952

agtagtttat ggagacattt tatttatcaa ctttaacaaa taaggtctta catgagttgg     2012

gaagcttgtg caacagaaaa gttttccaga aagtttattc aaagcataat gttaaagaca     2072

aacagtgtat caagaagttc agcttgtaag atacccagag ctgttagcac tgagtatgta     2132

tacacacaca cacacacaga gatccaccac tttagcttag ttagcagttc tcttcttctt     2192

cttccttttc ccttggcctt tacttggtgc cttctggttt gcactggtct gagctctgtg     2252

aatgaagtaa tataacagct cactgtatcc catctgtcct ggattgggtc actgggactc     2312

tgaaaggtgc cccattttat agaaccagct tttaatgtat atttgaaaga ggccagaaat     2372

ttgttacctt attttctttg ggttcttctc tggctccaaa ataatcattt cttcttcttc     2432

actatctgat agcactatag gggcaccttt ggaaaagtcc aaaaaaggag tttactgctt     2492

aagcacatca gaggtcctaa cgctcccatc tccaggctaa gggagctccc aagctctact     2552

gcccggaggc tgacactctt tccgaatctt accctgttct aagtaagtag ctccttgcag     2612

ctctgaaaat ttgtaaaaat tgatgttttc tataaactct ttctttcctt tttccccaga     2672

ggacatgtag gccagaatgc tctaattctt gctaccagga ctgcccatga aaaatgtaga     2732

aaactgcttt gtttgcccat ttttctcttg aacagtaatt atatatgtgt gtaaataaag     2792

catgcaaatt aaccctttaa aaaaaaaaaa aaaaa                                2827


<210>  6
<211>  422
<212>  PRT
<213>  Mus musculus

<400>  6

Met Pro Gly Thr Ser Arg His Ser Gly Arg Asp Ala Gly Ser Ala Leu 
1               5                   10                  15      


Leu Ser Leu His Gln Glu Asp Gln Glu Asn Val Asn Pro Glu Lys Leu 
            20                  25                  30          


Ala Pro Ala Gln Gln Pro Arg Ala Gln Ala Val Leu Lys Ala Gly Asn 
        35                  40                  45              


Val Arg Gly Pro Ala Pro Gln Gln Lys Leu Lys Thr Arg Arg Val Ala 
    50                  55                  60                  


Pro Leu Lys Asp Leu Pro Ile Asn Asp Glu His Val Thr Ala Gly Pro 
65                  70                  75                  80  


Ser Trp Lys Ala Val Ser Lys Gln Pro Ala Phe Thr Ile His Val Asp 
                85                  90                  95      


Glu Ala Glu Glu Thr Gln Lys Arg Pro Ala Glu Leu Lys Glu Thr Glu 
            100                 105                 110         


Cys Glu Asp Ala Leu Ala Phe Asn Ala Ala Val Ser Leu Pro Gly Ala 
        115                 120                 125             


Arg Lys Pro Leu Thr Pro Leu Asp Tyr Pro Met Asp Gly Ser Phe Glu 
    130                 135                 140                 


Ser Pro His Ala Met Asp Met Ser Ile Val Leu Glu Asp Lys Pro Val 
145                 150                 155                 160 


Asn Val Asn Glu Val Pro Asp Tyr Gln Glu Asp Ile His Thr Tyr Leu 
                165                 170                 175     


Arg Glu Met Glu Val Lys Cys Lys Pro Lys Val Gly Tyr Met Lys Arg 
            180                 185                 190         


Gln Pro Asp Ile Thr Asn Ser Met Arg Ala Ile Leu Val Asp Trp Leu 
        195                 200                 205             


Val Glu Val Gly Glu Glu Tyr Lys Leu Gln Asn Glu Thr Leu His Leu 
    210                 215                 220                 


Ala Val Asn Tyr Ile Asp Arg Phe Leu Ser Ser Met Ser Val Leu Arg 
225                 230                 235                 240 


Gly Lys Leu Gln Leu Val Gly Thr Ala Ala Met Leu Leu Ala Ser Lys 
                245                 250                 255     


Phe Glu Glu Ile Tyr Pro Pro Glu Val Ala Glu Phe Val Tyr Ile Thr 
            260                 265                 270         


Asp Asp Thr Tyr Ser Lys Lys Gln Val Leu Arg Met Glu His Leu Val 
        275                 280                 285             


Leu Lys Val Leu Ala Phe Asp Leu Ala Ala Pro Thr Val Asn Gln Phe 
    290                 295                 300                 


Leu Thr Gln Tyr Phe Leu His Leu Gln Pro Ala Asn Cys Lys Val Glu 
305                 310                 315                 320 


Ser Leu Ala Met Phe Leu Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro 
                325                 330                 335     


Tyr Leu Lys Tyr Leu Pro Ser Leu Ile Ala Gly Ala Ala Phe His Leu 
            340                 345                 350         


Ala Leu Tyr Thr Val Thr Gly Gln Ser Trp Pro Glu Ser Leu Ala Gln 
        355                 360                 365             


Gln Thr Gly Tyr Thr Leu Glu Ser Leu Lys Pro Cys Leu Val Asp Leu 
    370                 375                 380                 


His Gln Thr Tyr Leu Lys Ala Pro Gln His Ala Gln Gln Ser Ile Arg 
385                 390                 395                 400 


Glu Lys Tyr Lys His Ser Lys Tyr His Ser Val Ser Leu Leu Asn Pro 
                405                 410                 415     


Pro Glu Thr Leu Ser Val 
            420         


<210>  7
<211>  2811
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (306)..(1604)

<400>  7
ccatttcaat agtcgcggga tacttgaact gcaagaacag ccgccgctcc ggcgggctgc       60

tcgctgcatc tctgggcgtc tttggctcgc cacgctgggc agtgcctgcc tgcgcctttc      120

gcaacctcct cggccctgcg tggtctcgag ctgggtgagc gagcgggcgg gctggtaggc      180

tggcctgggc tgcgaccggc ggctacgact attctttggc cgggtcggtg cgagtggtcg      240

gctgggcaga gtgcacgctg cttggcgccg caggctgatc ccgccgtcca ctcccgggag      300

cagtg atg ttg ggc aac tct gcg ccg ggg cct gcg acc cgc gag gcg ggc      350
      Met Leu Gly Asn Ser Ala Pro Gly Pro Ala Thr Arg Glu Ala Gly         
      1               5                   10                  15          

tcg gcg ctg cta gca ttg cag cag acg gcg ctc caa gag gac cag gag        398
Ser Ala Leu Leu Ala Leu Gln Gln Thr Ala Leu Gln Glu Asp Gln Glu           
                20                  25                  30                

aat atc aac ccg gaa aag gca gcg ccc gtc caa caa ccg cgg acc cgg        446
Asn Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Thr Arg           
            35                  40                  45                    

gcc gcg ctg gcg gta ctg aag tcc ggg aac ccg cgg ggt cta gcg cag        494
Ala Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln           
        50                  55                  60                        

cag cag agg ccg aag acg aga cgg gtt gca ccc ctt aag gat ctt cct        542
Gln Gln Arg Pro Lys Thr Arg Arg Val Ala Pro Leu Lys Asp Leu Pro           
    65                  70                  75                            

gta aat gat gag cat gtc acc gtt cct cct tgg aaa gca aac agt aaa        590
Val Asn Asp Glu His Val Thr Val Pro Pro Trp Lys Ala Asn Ser Lys           
80                  85                  90                  95            

cag cct gcg ttc acc att cat gtg gat gaa gca gaa aaa gaa gct cag        638
Gln Pro Ala Phe Thr Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln           
                100                 105                 110               

aag aag cca gct gaa tct caa aaa ata gag cgt gaa gat gcc ctg gct        686
Lys Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala           
            115                 120                 125                   

ttt aat tca gcc att agt tta cct gga ccc aga aaa cca ttg gtc cct        734
Phe Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro           
        130                 135                 140                       

ctt gat tat cca atg gat ggt agt ttt gag tca cca cat act atg gac        782
Leu Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Thr Met Asp           
    145                 150                 155                           

atg tca att gta tta gaa gat gaa aag cca gtg agt gtt aat gaa gta        830
Met Ser Ile Val Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu Val           
160                 165                 170                 175           

cca gac tac cat gag gat att cac aca tac ctt agg gaa atg gag gtt        878
Pro Asp Tyr His Glu Asp Ile His Thr Tyr Leu Arg Glu Met Glu Val           
                180                 185                 190               

aaa tgt aaa cct aaa gtg ggt tac atg aag aaa cag cca gac atc act        926
Lys Cys Lys Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Thr           
            195                 200                 205                   

aac agt atg aga gct atc ctc gtg gac tgg tta gtt gaa gta gga gaa        974
Asn Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu           
        210                 215                 220                       

gaa tat aaa cta cag aat gag acc ctg cat ttg gct gtg aac tac att       1022
Glu Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala Val Asn Tyr Ile           
    225                 230                 235                           

gat agg ttc ctg tct tcc atg tca gtg ctg aga gga aaa ctt cag ctt       1070
Asp Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu           
240                 245                 250                 255           

gtg ggc act gct gct atg ctg tta gcc tca aag ttt gaa gaa ata tac       1118
Val Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr           
                260                 265                 270               

ccc cca gaa gta gca gag ttt gtg tac att aca gat gat acc tac acc       1166
Pro Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr           
            275                 280                 285                   

aag aaa caa gtt ctg aga atg gag cat cta gtt ttg aaa gtc ctt act       1214
Lys Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu Thr           
        290                 295                 300                       

ttt gac tta gct gct cca aca gta aat cag ttt ctt acc caa tac ttt       1262
Phe Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu Thr Gln Tyr Phe           
    305                 310                 315                           

ctg cat cag cag cct gca aac tgc aaa gtt gaa agt tta gca atg ttt       1310
Leu His Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe           
320                 325                 330                 335           

ttg gga gaa tta agt ttg ata gat gct gac cca tac ctc aag tat ttg       1358
Leu Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu           
                340                 345                 350               

cca tca gtt att gct gga gct gcc ttt cat tta gca ctc tac aca gtc       1406
Pro Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Thr Val           
            355                 360                 365                   

acg gga caa agc tgg cct gaa tca tta ata cga aag act gga tat acc       1454
Thr Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly Tyr Thr           
        370                 375                 380                       

ctg gaa agt ctt aag cct tgt ctc atg gac ctt cac cag acc tac ctc       1502
Leu Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Thr Tyr Leu           
    385                 390                 395                           

aaa gca cca cag cat gca caa cag tca ata aga gaa aag tac aaa aat       1550
Lys Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn           
400                 405                 410                 415           

tca aag tat cat ggt gtt tct ctc ctc aac cca cca gag aca cta aat       1598
Ser Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Thr Leu Asn           
                420                 425                 430               

ctg taa caatgaaaga ctgcctttgt tttctaagat gtaaatcact caaagtatat        1654
Leu                                                                       
                                                                          

ggtgtacagt ttttaactta ggttttaatt ttacaatcat ttctgaatac agaagttgtg     1714

gccaagtaca aattatggta tctattactt tttaaatggt tttaatttgt atatcttttg     1774

tatatgtatc tgtcttagat atttggctaa ttttaagtgg ttttgttaaa gtattaatga     1834

tgccagctgt caggataata aattgatttg gaaaactttg caagtcaaat ttaacttctt     1894

caggattttg cttagtaaag aagtttactt ggtttactat ataatgggaa gtgaaaagcc     1954

ttcctctaaa attaaagtag gtttaggaaa acagaccctc aaattctgac attcattttc     2014

ctaagcaact ggatcaattt gctgacttgg gcataatcta atctaagcat atctgaatac     2074

agtattcaga gatagataca gtagagattc cccagacttt ttcgctcttt gtaaaacctg     2134

tttgtttagg ttttgcgagg taaactcaac agaggttggg agtggaagag ggtgggaagc     2194

ttatatgcaa attaacagac gagaaatgct ccagaaggtt tattatttta aagcacatta     2254

aaaacaaaaa actattttta aaatcctgct agattttata atggatttgt gaataaaaaa     2314

tacccagggt tctcagaatg gaataaatat cccttttaat agttatatat acagatatac     2374

aactgttagc tttaattggc agctctcttc ttttttcttc ttttcactgg ctttttactt     2434

ggtgcttttt cttgttttgc actggtggtc tgtgttctgt gaataaagca aagtaagaat     2494

ttactaagag tatgttaagt tttggattat tgaaataaga ggcatttctt agttttccag     2554

taggatctaa aatgtgtcag ctatgagtaa gactggcatc caagaagttt atattataga     2614

tttaggtcct aatttttata aatcacaagg taaaaaaatc acagaacaga tggatctcta     2674

atgaaaaagg gatgtctttt tgtttatagt catgtggcaa gatgagagta aaaccagaga     2734

gcaaacctct ataagtgttg agtatatgta tacatttgaa ataaaccaga aatttgttac     2794

cttaaaaaaa aaaaaaa                                                    2811


<210>  8
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Gly Asn Ser Ala Pro Gly Pro Ala Thr Arg Glu Ala Gly Ser 
1               5                   10                  15      


Ala Leu Leu Ala Leu Gln Gln Thr Ala Leu Gln Glu Asp Gln Glu Asn 
            20                  25                  30          


Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Thr Arg Ala 
        35                  40                  45              


Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln Gln 
    50                  55                  60                  


Gln Arg Pro Lys Thr Arg Arg Val Ala Pro Leu Lys Asp Leu Pro Val 
65                  70                  75                  80  


Asn Asp Glu His Val Thr Val Pro Pro Trp Lys Ala Asn Ser Lys Gln 
                85                  90                  95      


Pro Ala Phe Thr Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln Lys 
            100                 105                 110         


Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala Phe 
        115                 120                 125             


Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro Leu 
    130                 135                 140                 


Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Thr Met Asp Met 
145                 150                 155                 160 


Ser Ile Val Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu Val Pro 
                165                 170                 175     


Asp Tyr His Glu Asp Ile His Thr Tyr Leu Arg Glu Met Glu Val Lys 
            180                 185                 190         


Cys Lys Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Thr Asn 
        195                 200                 205             


Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 
    210                 215                 220                 


Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala Val Asn Tyr Ile Asp 
225                 230                 235                 240 


Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 
                245                 250                 255     


Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr Pro 
            260                 265                 270         


Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr Lys 
        275                 280                 285             


Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu Thr Phe 
    290                 295                 300                 


Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu Thr Gln Tyr Phe Leu 
305                 310                 315                 320 


His Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe Leu 
                325                 330                 335     


Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 
            340                 345                 350         


Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Thr Val Thr 
        355                 360                 365             


Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly Tyr Thr Leu 
    370                 375                 380                 


Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Thr Tyr Leu Lys 
385                 390                 395                 400 


Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn Ser 
                405                 410                 415     


Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Thr Leu Asn Leu 
            420                 425                 430         


<210>  9
<211>  5148
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (217)..(2106)

<400>  9
ccacttccct agttacagac accacttaac agcaggaaac ctccacttgc tctcctctgc       60

cttctctcca ttgcagccat tcccattttc aagactgcca gtctggtcct ttcaacgttc      120

catgctgcct ggtgcccggg agcccaggcc ttctgtgact ccaggacagg aaggtacttc      180

tccatacact tcccagaact ctgaaggggt gcagac atg gcg gga agt gct gtg        234
                                        Met Ala Gly Ser Ala Val           
                                        1               5                 

gac agc gcc aac cac ctg acc tac ttt ttt ggc aac atc acc cgg gaa        282
Asp Ser Ala Asn His Leu Thr Tyr Phe Phe Gly Asn Ile Thr Arg Glu           
            10                  15                  20                    

gag gct gaa gac tac ctg gtc cag gga ggc atg acc gat ggg ctc tac        330
Glu Ala Glu Asp Tyr Leu Val Gln Gly Gly Met Thr Asp Gly Leu Tyr           
        25                  30                  35                        

ctg cta cgc cag agc cgc aat tac ctg ggt ggt ttt gct ttg tcg gtg        378
Leu Leu Arg Gln Ser Arg Asn Tyr Leu Gly Gly Phe Ala Leu Ser Val           
    40                  45                  50                            

gct cac aac agg aag gca cac cac tac acc atc gag agg gaa ctt aat        426
Ala His Asn Arg Lys Ala His His Tyr Thr Ile Glu Arg Glu Leu Asn           
55                  60                  65                  70            

ggc acc tac gcc atc tcc ggg ggc agg gcc cat gcc agc cca gca gac        474
Gly Thr Tyr Ala Ile Ser Gly Gly Arg Ala His Ala Ser Pro Ala Asp           
                75                  80                  85                

ctc tgc cat tac cac tcc cag gaa cct gat ggc ctt atc tgc ctc ctt        522
Leu Cys His Tyr His Ser Gln Glu Pro Asp Gly Leu Ile Cys Leu Leu           
            90                  95                  100                   

aag aag ccc ttc aac cgg ccc ccg gga gta cag ccc aag acc gga ccc        570
Lys Lys Pro Phe Asn Arg Pro Pro Gly Val Gln Pro Lys Thr Gly Pro           
        105                 110                 115                       

ttt gag gac ctg aag gag aac ctc atc agg gaa tat gtg aaa cag acc        618
Phe Glu Asp Leu Lys Glu Asn Leu Ile Arg Glu Tyr Val Lys Gln Thr           
    120                 125                 130                           

tgg aac ctt cag ggc cag gct ctg gag caa gcc atc atc agc cag aag        666
Trp Asn Leu Gln Gly Gln Ala Leu Glu Gln Ala Ile Ile Ser Gln Lys           
135                 140                 145                 150           

ccc cag ctg gag aag ctg atc gcc acc acg gcc cat gag aag atg ccc        714
Pro Gln Leu Glu Lys Leu Ile Ala Thr Thr Ala His Glu Lys Met Pro           
                155                 160                 165               

tgg ttc cat ggc aac atc tcc aga gat gaa tca gag cag acg gtc ctc        762
Trp Phe His Gly Asn Ile Ser Arg Asp Glu Ser Glu Gln Thr Val Leu           
            170                 175                 180                   

ata ggg tca aag acc aat gga aaa ttc ctg atc agg gcc aga gac aac        810
Ile Gly Ser Lys Thr Asn Gly Lys Phe Leu Ile Arg Ala Arg Asp Asn           
        185                 190                 195                       

agc ggc tcc tat gct ctg tgc ctg ctg cac gaa ggg aaa gta ttg cac        858
Ser Gly Ser Tyr Ala Leu Cys Leu Leu His Glu Gly Lys Val Leu His           
    200                 205                 210                           

tac cgc att gac agg gac aag acc ggg aag ctc tcc att cct gag ggg        906
Tyr Arg Ile Asp Arg Asp Lys Thr Gly Lys Leu Ser Ile Pro Glu Gly           
215                 220                 225                 230           

aag aag ttt gac acc ctc tgg cag cta gtg gaa cat tac tct tac aag        954
Lys Lys Phe Asp Thr Leu Trp Gln Leu Val Glu His Tyr Ser Tyr Lys           
                235                 240                 245               

cca gat ggg cta cta aga gtc ctc acg gta cca tgc caa aag att ggt       1002
Pro Asp Gly Leu Leu Arg Val Leu Thr Val Pro Cys Gln Lys Ile Gly           
            250                 255                 260                   

gca cag atg ggc cac cca gga agc cca aat gcc cat ccc gtg act tgg       1050
Ala Gln Met Gly His Pro Gly Ser Pro Asn Ala His Pro Val Thr Trp           
        265                 270                 275                       

tca ccg ggt gga ata atc tca agg atc aaa tcc tac tcc ttc cca aag       1098
Ser Pro Gly Gly Ile Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys           
    280                 285                 290                           

cct ggc cac aaa aag cct gcc cca ccc caa ggg agc cgt cca gag agc       1146
Pro Gly His Lys Lys Pro Ala Pro Pro Gln Gly Ser Arg Pro Glu Ser           
295                 300                 305                 310           

act gtg tcc ttc aac ccc tat gag cca acg gga ggg ccc tgg ggc cca       1194
Thr Val Ser Phe Asn Pro Tyr Glu Pro Thr Gly Gly Pro Trp Gly Pro           
                315                 320                 325               

gac aga ggc ctt cag aga gaa gcc ctg ccc atg gac aca gag gtg tac       1242
Asp Arg Gly Leu Gln Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr           
            330                 335                 340                   

gag agc cct tat gct gac cct gaa gag atc cgg ccc aaa gag gtc tac       1290
Glu Ser Pro Tyr Ala Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr           
        345                 350                 355                       

ctg gac agg agc ctg ctg acc ctg gag gac aat gaa ctg ggc tcc ggt       1338
Leu Asp Arg Ser Leu Leu Thr Leu Glu Asp Asn Glu Leu Gly Ser Gly           
    360                 365                 370                           

aac ttc ggg act gtg aaa aag gga tac tac caa atg aaa aaa gtt gtg       1386
Asn Phe Gly Thr Val Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val           
375                 380                 385                 390           

aaa acc gtg gct gtg aaa atc ctg aag aac gag gcc aac gac ccg gct       1434
Lys Thr Val Ala Val Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala           
                395                 400                 405               

ttg aag gac gag ctg ctg gca gag gcg aac gtc atg cag cag ctg gac       1482
Leu Lys Asp Glu Leu Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp           
            410                 415                 420                   

aac ccc tac att gtg cgc atg atc gga atc tgc gag gcg gag tcc tgg       1530
Asn Pro Tyr Ile Val Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp           
        425                 430                 435                       

atg ctg gtg atg gag atg gcg gag ctg ggg ccg ctc aac aag tac ctg       1578
Met Leu Val Met Glu Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu           
    440                 445                 450                           

cag cag aac agg cac att aag gat aag aac atc ata gag ctg gtt cac       1626
Gln Gln Asn Arg His Ile Lys Asp Lys Asn Ile Ile Glu Leu Val His           
455                 460                 465                 470           

cag gtt tcc atg ggg atg aag tat ttg gaa gag agc aac ttt gtg cac       1674
Gln Val Ser Met Gly Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His           
                475                 480                 485               

aga gat ctg gct gcg cgg aac gtg ctt ctg gtc aca cag cac tat gcc       1722
Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala           
            490                 495                 500                   

aag atc agc gat ttc ggt ctt tcc aaa gcc ctg cgt gct gat gaa aac       1770
Lys Ile Ser Asp Phe Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn           
        505                 510                 515                       

tac tac aag gcc cag acc cac ggg aag tgg ccc gtg aag tgg tac gcc       1818
Tyr Tyr Lys Ala Gln Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala           
    520                 525                 530                           

ccc gaa tgc atc aac tac tac aag ttc tcc agt aag agt gac gtc tgg       1866
Pro Glu Cys Ile Asn Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp           
535                 540                 545                 550           

agc ttc gga gtc ctg atg tgg gaa gcg ttc tcc tat ggg cag aag ccc       1914
Ser Phe Gly Val Leu Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro           
                555                 560                 565               

tac aga ggg atg aaa ggg agc gaa gtg acc gcc atg ctg gag aaa gga       1962
Tyr Arg Gly Met Lys Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly           
            570                 575                 580                   

gag cgg atg ggg tgc cct gca gga tgc ccg aga gag atg tac gac ctg       2010
Glu Arg Met Gly Cys Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu           
        585                 590                 595                       

atg aac ctg tgc tgg act tac gat gtg gag aac agg cca gga ttc aca       2058
Met Asn Leu Cys Trp Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Thr           
    600                 605                 610                           

gct gtg gaa ctg agg ctt cgc aat tac tac tac gac gtg gtt aac taa       2106
Ala Val Glu Leu Arg Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn               
615                 620                 625                               

cagctccggc gcctgtccgt gcacaccacg gattcccaag cgatcacagg aaattcattc     2166

agatgaactg gctctcagag tttcatctcc ctctgcccgg agtgagagct aagctaacat     2226

aggactcacc ctcacaacag gtctggtgcc cagagacaga caagcagcaa gaccttgggg     2286

cctgtggagt cgtctctctg gtctttgttt ccatctgtgt ggtcttcgct atcggtcacg     2346

tttgggagcc atttccaaat tctcttgaca tcattccgtt cctctgggtc caggatttca     2406

gtgtcccctg aagatcagaa aagaaaagtg ctttgccact ccagcaaagg acataaagag     2466

aaacctcgct ggtgcagtca gcaagctgga aggtggttaa ggacaatgac aagcctggac     2526

actggtttta ctctcagcgc tgagacagag atactgtgtg gatgacatgc tgagatgtgc     2586

tggcttggct gacacgcccc tggagtccac ctccctgcag tcgtgtgtgt ttgctggagg     2646

aggtgtgaat aacgttctgt gtggaggctg ccgggggagg tgagctccca tgatcctctg     2706

cgactgagca gaagtgtgtc aggcaagggt cagactcccc tctctgcaga gggaatgcat     2766

ccaggactcc ttgttgctgc cactaaaaaa ttgccaacca gcaacttaag ggaggaatgg     2826

ctcatttgag ctcacagttg gaggggatag gccatcatgg tggaaaagac aacaggcagg     2886

aaaggcttgg tggcatgaaa aggaagctgg aaggtcacat ggcatccaca ttcaggaaac     2946

aaagaatgaa caggaagtgg ggccaggcta taaggcccta aaggccacct ccggtgaccc     3006

agttccttca gatccatcta tcaaagattc cacaggcctc tcagacactg aatgccaaca     3066

gctggggacc aaatgttcaa gcacacaagg tgcagtgcca ggcaggggcc ttcctgaatg     3126

attacacagt gtggtatcct gacagagcgg gtgagccatc tcaggtctgt ccccttatga     3186

gccccgttta ccatcccaga ttcccccttg ggacccccct catctggatc attcccctcc     3246

ccccaggccc tatctccaaa cacctaggta ctaagtgaac ctaggtacta agtcttcaac     3306

acatgaattc tgaggggaca cattcatact ggagccgatg gcagcctggt gaccaagacc     3366

atctcaggat gagtttctga atggaatctt cattcgccat aaaaccagag atgtgacctt     3426

ccccacaagg aagccttgct aagtgcgaca ttgagctgag gacacacaag ctgagaattc     3486

cccctctgtc ctcctagcct tggctaacta ctgaccatac accgaatgtc acccattcac     3546

ggcacttttg ctgaggacct aaaagctaca aaggctgcat agccttccat ctaggtctag     3606

ggacatgtac agatgggagc atctcacctt cacctctgag acactgggac attcacagcc     3666

agggatggta caggagtccc tgctggtggt gggctcaatg aacagagacg atggtgaaat     3726

gggtgcctct ctttagacca gtggttctca accttcctaa tgctgagatc tttcaataca     3786

ggtccttgcg ttgtggcgac tcccaaccat gaagttattt tgttgctaca ttgtcactgt     3846

aattttgcta ctatgatgaa tcgtagtgta gatatctgat atgcaggata tcggatatgt     3906

aaatatctgg tatgcaggat atgtgaaatg agggcacatc ccacaggttg ggaaccactg     3966

cctttgatag ggaggcacta tgcttagagc atggttagga agtatttaga agctattggt     4026

gtgtcttgga attgtgttag taggtcaacc gtcctgtgga gggaaggaag ggggtggagg     4086

aaatccctgt atgttgaatt cattgagcag acctgcagaa cacagccttg gtgaggaagt     4146

cccatgggtc agaccacctg tagatttagt caggagagga agggccactg tatagttatg     4206

gagacaggac tgtctgctct gagcaagaag ttctctgctg agctcctagc ctaccttccc     4266

ttgtccccag ggctatagaa aggccacctc gaagaccagg gagcatgtgt gagaagtctg     4326

tggaggcctc tgccttcttc ctggcctctc tagcagtgcc tctccttccc agggatttgg     4386

gactgaccgt tatctggcta tgactgagca gagtggaggg atgggctttg ccccccttca     4446

gaaagccgaa accggttccc atgtgcagag tcacatgtgg ccatcgacca gggctctcat     4506

ctggtgaaaa ctgtgtctta ctgtcaagat taattctctc ccctgggcca ctgaggaggg     4566

cagatggcaa gaggatcctc cctagaggat ttagactatg aatgcccact aaatttgcaa     4626

ggtcagaaac tagccaaggt ccttctcagg catctatcct taacttggtc tctccacaag     4686

ctgcctctga tgctccgagc cccttctgcc tggcagctgg gctccctgtg tgcttttacc     4746

tatgaccctt ggtcagcaga gtacaaggag cacctaagct gcctcgccac ctcccactga     4806

ctgcaaacac cacatacctc atgcggaacc gaatgtctct ccagtaaaca ccccagccag     4866

ccattcataa aaacctgtct ctgtgtgcgc tgggacatgt cctccctgta ccccgggcct     4926

gctttgtgtg ccagacagtg actccacagg gatgccaggt ctgtgattgc attgctcctt     4986

gcagagggaa gccctcggtt gtccttctct gggaatgctg ccacccagag cagcacacag     5046

tgattccctg ttatttcaga aattatttta aataaagatc tactattagt cttgtgaaaa     5106

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                        5148


<210>  10
<211>  629
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Gly Ser Ala Val Asp Ser Ala Asn His Leu Thr Tyr Phe Phe 
1               5                   10                  15      


Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly Gly 
            20                  25                  30          


Met Thr Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu Gly 
        35                  40                  45              


Gly Phe Ala Leu Ser Val Ala His Asn Arg Lys Ala His His Tyr Thr 
    50                  55                  60                  


Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ser Gly Gly Arg Ala 
65                  70                  75                  80  


His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Pro Asp 
                85                  90                  95      


Gly Leu Ile Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Pro Gly Val 
            100                 105                 110         


Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile Arg 
        115                 120                 125             


Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu Gln 
    130                 135                 140                 


Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr Thr 
145                 150                 155                 160 


Ala His Glu Lys Met Pro Trp Phe His Gly Asn Ile Ser Arg Asp Glu 
                165                 170                 175     


Ser Glu Gln Thr Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe Leu 
            180                 185                 190         


Ile Arg Ala Arg Asp Asn Ser Gly Ser Tyr Ala Leu Cys Leu Leu His 
        195                 200                 205             


Glu Gly Lys Val Leu His Tyr Arg Ile Asp Arg Asp Lys Thr Gly Lys 
    210                 215                 220                 


Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu Val 
225                 230                 235                 240 


Glu His Tyr Ser Tyr Lys Pro Asp Gly Leu Leu Arg Val Leu Thr Val 
                245                 250                 255     


Pro Cys Gln Lys Ile Gly Ala Gln Met Gly His Pro Gly Ser Pro Asn 
            260                 265                 270         


Ala His Pro Val Thr Trp Ser Pro Gly Gly Ile Ile Ser Arg Ile Lys 
        275                 280                 285             


Ser Tyr Ser Phe Pro Lys Pro Gly His Lys Lys Pro Ala Pro Pro Gln 
    290                 295                 300                 


Gly Ser Arg Pro Glu Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Thr 
305                 310                 315                 320 


Gly Gly Pro Trp Gly Pro Asp Arg Gly Leu Gln Arg Glu Ala Leu Pro 
                325                 330                 335     


Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr Ala Asp Pro Glu Glu Ile 
            340                 345                 350         


Arg Pro Lys Glu Val Tyr Leu Asp Arg Ser Leu Leu Thr Leu Glu Asp 
        355                 360                 365             


Asn Glu Leu Gly Ser Gly Asn Phe Gly Thr Val Lys Lys Gly Tyr Tyr 
    370                 375                 380                 


Gln Met Lys Lys Val Val Lys Thr Val Ala Val Lys Ile Leu Lys Asn 
385                 390                 395                 400 


Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu Leu Ala Glu Ala Asn 
                405                 410                 415     


Val Met Gln Gln Leu Asp Asn Pro Tyr Ile Val Arg Met Ile Gly Ile 
            420                 425                 430         


Cys Glu Ala Glu Ser Trp Met Leu Val Met Glu Met Ala Glu Leu Gly 
        435                 440                 445             


Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg His Ile Lys Asp Lys Asn 
    450                 455                 460                 


Ile Ile Glu Leu Val His Gln Val Ser Met Gly Met Lys Tyr Leu Glu 
465                 470                 475                 480 


Glu Ser Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Leu 
                485                 490                 495     


Val Thr Gln His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser Lys Ala 
            500                 505                 510         


Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln Thr His Gly Lys Trp 
        515                 520                 525             


Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn Tyr Tyr Lys Phe Ser 
    530                 535                 540                 


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ala Phe 
545                 550                 555                 560 


Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys Gly Ser Glu Val Thr 
                565                 570                 575     


Ala Met Leu Glu Lys Gly Glu Arg Met Gly Cys Pro Ala Gly Cys Pro 
            580                 585                 590         


Arg Glu Met Tyr Asp Leu Met Asn Leu Cys Trp Thr Tyr Asp Val Glu 
        595                 600                 605             


Asn Arg Pro Gly Phe Thr Ala Val Glu Leu Arg Leu Arg Asn Tyr Tyr 
    610                 615                 620                 


Tyr Asp Val Val Asn 
625                 


<210>  11
<211>  5079
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (206)..(2113)

<400>  11
acactgggag gaagtgcggg ccgcctgccc gggcgcgtta aggaagttgc ccaaaatgag       60

gaagagccgc gggcccggcg gctgaggcca ccccggcggc ggctggagag cgaggaggag      120

cgggtggccc cgcgctgcgc ccgccctcgc ctcacctggc gcaggtggac acctgcgcag      180

gtgtgtgccc tccggcccct gaagc atg gcc agc agc ggc atg gct gac agc        232
                            Met Ala Ser Ser Gly Met Ala Asp Ser           
                            1               5                             

gcc aac cac ctg ccc ttc ttt ttc ggc aac atc acc cgg gag gag gca        280
Ala Asn His Leu Pro Phe Phe Phe Gly Asn Ile Thr Arg Glu Glu Ala           
10                  15                  20                  25            

gaa gat tac ctg gtc cag ggg ggc atg agt gat ggg ctt tat ttg ctg        328
Glu Asp Tyr Leu Val Gln Gly Gly Met Ser Asp Gly Leu Tyr Leu Leu           
                30                  35                  40                

cgc cag agc cgc aac tac ctg ggt ggc ttc gcc ctg tcc gtg gcc cac        376
Arg Gln Ser Arg Asn Tyr Leu Gly Gly Phe Ala Leu Ser Val Ala His           
            45                  50                  55                    

ggg agg aag gca cac cac tac acc atc gag cgg gag ctg aat ggc acc        424
Gly Arg Lys Ala His His Tyr Thr Ile Glu Arg Glu Leu Asn Gly Thr           
        60                  65                  70                        

tac gcc atc gcc ggt ggc agg acc cat gcc agc ccc gcc gac ctc tgc        472
Tyr Ala Ile Ala Gly Gly Arg Thr His Ala Ser Pro Ala Asp Leu Cys           
    75                  80                  85                            

cac tac cac tcc cag gag tct gat ggc ctg gtc tgc ctc ctc aag aag        520
His Tyr His Ser Gln Glu Ser Asp Gly Leu Val Cys Leu Leu Lys Lys           
90                  95                  100                 105           

ccc ttc aac cgg ccc caa ggg gtg cag ccc aag act ggg ccc ttt gag        568
Pro Phe Asn Arg Pro Gln Gly Val Gln Pro Lys Thr Gly Pro Phe Glu           
                110                 115                 120               

gat ttg aag gaa aac ctc atc agg gaa tat gtg aag cag aca tgg aac        616
Asp Leu Lys Glu Asn Leu Ile Arg Glu Tyr Val Lys Gln Thr Trp Asn           
            125                 130                 135                   

ctg cag ggt cag gct ctg gag cag gcc atc atc agt cag aag cct cag        664
Leu Gln Gly Gln Ala Leu Glu Gln Ala Ile Ile Ser Gln Lys Pro Gln           
        140                 145                 150                       

ctg gag aag ctg atc gct acc aca gcc cat gaa aaa atg cct tgg ttc        712
Leu Glu Lys Leu Ile Ala Thr Thr Ala His Glu Lys Met Pro Trp Phe           
    155                 160                 165                           

cat gga aaa atc tct cgg gaa gaa tct gag caa att gtc ctg ata gga        760
His Gly Lys Ile Ser Arg Glu Glu Ser Glu Gln Ile Val Leu Ile Gly           
170                 175                 180                 185           

tca aag aca aat gga aag ttc ctg atc cga gcc aga gac aac aac ggc        808
Ser Lys Thr Asn Gly Lys Phe Leu Ile Arg Ala Arg Asp Asn Asn Gly           
                190                 195                 200               

tcc tac gcc ctg tgc ctg ctg cac gaa ggg aag gtg ctg cac tat cgc        856
Ser Tyr Ala Leu Cys Leu Leu His Glu Gly Lys Val Leu His Tyr Arg           
            205                 210                 215                   

atc gac aaa gac aag aca ggg aag ctc tcc atc ccc gag gga aag aag        904
Ile Asp Lys Asp Lys Thr Gly Lys Leu Ser Ile Pro Glu Gly Lys Lys           
        220                 225                 230                       

ttc gac acg ctc tgg cag cta gtc gag cat tat tct tat aaa gca gat        952
Phe Asp Thr Leu Trp Gln Leu Val Glu His Tyr Ser Tyr Lys Ala Asp           
    235                 240                 245                           

ggt ttg tta aga gtt ctt act gtc cca tgt caa aaa atc ggc aca cag       1000
Gly Leu Leu Arg Val Leu Thr Val Pro Cys Gln Lys Ile Gly Thr Gln           
250                 255                 260                 265           

gga aat gtt aat ttt gga ggc cgt cca caa ctt cca ggt tcc cat cct       1048
Gly Asn Val Asn Phe Gly Gly Arg Pro Gln Leu Pro Gly Ser His Pro           
                270                 275                 280               

gcg act tgg tca gcg ggt gga ata atc tca aga atc aaa tca tac tcc       1096
Ala Thr Trp Ser Ala Gly Gly Ile Ile Ser Arg Ile Lys Ser Tyr Ser           
            285                 290                 295                   

ttc cca aag cct ggc cac aga aag tcc tcc cct gcc caa ggg aac cgg       1144
Phe Pro Lys Pro Gly His Arg Lys Ser Ser Pro Ala Gln Gly Asn Arg           
        300                 305                 310                       

caa gag agt act gtg tca ttc aat ccg tat gag cca gaa ctt gca ccc       1192
Gln Glu Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Glu Leu Ala Pro           
    315                 320                 325                           

tgg gct gca gac aaa ggc ccc cag aga gaa gcc cta ccc atg gac aca       1240
Trp Ala Ala Asp Lys Gly Pro Gln Arg Glu Ala Leu Pro Met Asp Thr           
330                 335                 340                 345           

gag gtg tac gag agc ccc tac gcg gac ccc gag gag atc agg ccc aag       1288
Glu Val Tyr Glu Ser Pro Tyr Ala Asp Pro Glu Glu Ile Arg Pro Lys           
                350                 355                 360               

gag gtt tac ctg gac cga aag ctg ctg acg ctg gaa gac aaa gaa ctg       1336
Glu Val Tyr Leu Asp Arg Lys Leu Leu Thr Leu Glu Asp Lys Glu Leu           
            365                 370                 375                   

ggc tct ggt aat ttt gga act gtg aaa aag ggc tac tac caa atg aaa       1384
Gly Ser Gly Asn Phe Gly Thr Val Lys Lys Gly Tyr Tyr Gln Met Lys           
        380                 385                 390                       

aaa gtt gtg aaa acc gtg gct gtg aaa ata ctg aaa aac gag gcc aat       1432
Lys Val Val Lys Thr Val Ala Val Lys Ile Leu Lys Asn Glu Ala Asn           
    395                 400                 405                           

gac ccc gct ctt aaa gat gag tta tta gca gaa gca aat gtc atg cag       1480
Asp Pro Ala Leu Lys Asp Glu Leu Leu Ala Glu Ala Asn Val Met Gln           
410                 415                 420                 425           

cag ctg gac aac ccg tac atc gtg cgg atg atc ggg ata tgc gag gcc       1528
Gln Leu Asp Asn Pro Tyr Ile Val Arg Met Ile Gly Ile Cys Glu Ala           
                430                 435                 440               

gag tcc tgg atg ctg gtt atg gag atg gca gaa ctt ggt ccc ctc aat       1576
Glu Ser Trp Met Leu Val Met Glu Met Ala Glu Leu Gly Pro Leu Asn           
            445                 450                 455                   

aag tat ttg cag cag aac aga cat gtc aag gat aag aac atc ata gaa       1624
Lys Tyr Leu Gln Gln Asn Arg His Val Lys Asp Lys Asn Ile Ile Glu           
        460                 465                 470                       

ctg gtt cat cag gtt tcc atg ggc atg aag tac ttg gag gag agc aat       1672
Leu Val His Gln Val Ser Met Gly Met Lys Tyr Leu Glu Glu Ser Asn           
    475                 480                 485                           

ttt gtg cac aga gat ctg gct gca aga aat gtg ttg cta gtt acc caa       1720
Phe Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Val Thr Gln           
490                 495                 500                 505           

cat tac gcc aag atc agt gat ttc gga ctt tcc aaa gca ctg cgt gct       1768
His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser Lys Ala Leu Arg Ala           
                510                 515                 520               

gat gaa aac tac tac aag gcc cag acc cat gga aag tgg cct gtc aag       1816
Asp Glu Asn Tyr Tyr Lys Ala Gln Thr His Gly Lys Trp Pro Val Lys           
            525                 530                 535                   

tgg tac gct ccg gaa tgc atc aac tac tac aag ttc tcc agc aaa agc       1864
Trp Tyr Ala Pro Glu Cys Ile Asn Tyr Tyr Lys Phe Ser Ser Lys Ser           
        540                 545                 550                       

gat gtc tgg agc ttt gga gtg ttg atg tgg gaa gca ttc tcc tat ggg       1912
Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ala Phe Ser Tyr Gly           
    555                 560                 565                           

cag aag cca tat cga ggg atg aaa gga agt gaa gtc acc gct atg tta       1960
Gln Lys Pro Tyr Arg Gly Met Lys Gly Ser Glu Val Thr Ala Met Leu           
570                 575                 580                 585           

gag aaa gga gag cgg atg ggg tgc cct gca ggg tgt cca aga gag atg       2008
Glu Lys Gly Glu Arg Met Gly Cys Pro Ala Gly Cys Pro Arg Glu Met           
                590                 595                 600               

tac gat ctc atg aat ctg tgc tgg aca tac gat gtg gaa aac agg ccc       2056
Tyr Asp Leu Met Asn Leu Cys Trp Thr Tyr Asp Val Glu Asn Arg Pro           
            605                 610                 615                   

gga ttc gca gca gtg gaa ctg cgg ctg cgc aat tac tac tat gac gtg       2104
Gly Phe Ala Ala Val Glu Leu Arg Leu Arg Asn Tyr Tyr Tyr Asp Val           
        620                 625                 630                       

gtg aac taa ccgctcccgc acctgtcggt ggctgccttt gatcacagga               2153
Val Asn                                                                   
    635                                                                   

gcaatcacag gaaaatgtat ccagaggaat tgattgtcag ccacctccct ctgccagtcg     2213

ggagagccag gcttggatgg aacatgccca caacttgtca cccaaagcct gtcccaggac     2273

tcaccctcca caaagcaaag gcagtcccgg gagaaaagac ggatggcagg atccaagggg     2333

ctagctggat ttgtttgttt tcttgtctgt gtgattttca tacaggttat ttttacgatc     2393

tgtttccaaa tccctttcat gtctttccac ttctctgggt cccggggtgc atttgttact     2453

catcgggccc agggacattg cagagtggcc tagagcactc tcaccccaag cggccttttc     2513

caaatgccca aggatgcctt agcatgtgac tcctgaaggg aaggcaaagg cagaggaatt     2573

tggctgcttc tacggccatg agactgatcc ctggccactg aaaagctttc ctgacaataa     2633

aaatgttttg aggctttaaa aagaaaatca agtttgacca gtgcagtttc taagcatgta     2693

gccagttaag gaaagaaaga aagaaaaaaa aaaaaggcct ggatactgct tttgctgtct     2753

ctgttatgag atggaagact tacatgtttg tgataaaagg ggaccatgag aatgaattgg     2813

cttggcttac tttccccctg aaatcctctc tcctgcagac tgtcttgaag acctggtgac     2873

tggtaaataa agccctgcat ggaggctgca cagcaggggc aagaggccca tcccccagca     2933

tctcactgag gacagcttca ggctgccttc ctctgaacgt ggtccacacc ttcctctcct     2993

ccacagagag ggtgccgcca gaatcccctg tcgctttctg tgtctgcaat ggggggcagc     3053

acagggatca aagccatcta aagagtttcc aaagaaagta ttaattcaga acaagccaaa     3113

gaccctgagc ctcaccacaa acaggccttt tggagtgtga atttgagttg aagatacaag     3173

atcggagaat gattttctgg tcttaactaa tcctcatctt catgtttgat ctttaagaag     3233

tcatcaccca ttgatttcag ttttgctgta cctcttgaaa gttaaagaga catctcagca     3293

ctttaggagg ccgaggcggg tggatcactt gaggtaagga gtttgagact agcctggcca     3353

atatggtaaa accccatctc tactaaaaat acaaaaatta gccgggcatg gtggcatgtg     3413

tctgtagtcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc caggaaacgg     3473

aggtcgcagt gagccaagat catgccactg cactccagct tgggcatcac agcgagactc     3533

tgtcaaaaca aacaaacaaa aaaacaactt aaagaggtaa tttagccatc attcttatgc     3593

cagcagatat aaataaactt ggacccatct ggtcttcagc taaacctgag acattttaaa     3653

gtgcatggac agccatggac agcaggccct cctctaacag gggatgcaag gcatggagaa     3713

agacaatcag tacccaagct cagccacaga agacaggagt cactcatata acttgtgttt     3773

agaagttttt ggtagccacg cacactttct gaaatcacac tatctggtgg tttaatcata     3833

tttttaaaga cagaatccct gagtgctgag cagattctca aaacacattt agaatccctg     3893

aaattagaaa gatcaatgac aaaatatctg tcagccaggc cacaaacagg tgtaaaatta     3953

tgaaaggagt ggttggatgt gccaagtttg gtaaagtggt gactgcatct gagaaagagg     4013

ctgtgaggct gaactcttgg tggcttcctt ctgtaacttc cagagggagt cttcaacaca     4073

ggccccgtgc tcgtaggaat acggtagcac ctatgtagga agtgcgtgga gttttctgtc     4133

ttctttctgt gtgatttttg gcctttttat cagcacttct cccctcccag gagcctgggg     4193

atgccaaaca tccagaatgt gatgggacaa gatgggggca ggggcctcac ctccctgcag     4253

aggtccggcc aggtctcctt gtccctggac aatctcctga gcctctctgc ttggtggagc     4313

aggcacctgt gtgcagaatt cccactgtgg ccagcacgag gaagtctttt ctagtgaaaa     4373

tgtgtcttgt ggtcaggaat aattatcctt tcccctgtag ccaccaagga gggcaaatag     4433

agaaaggtaa cctaattgaa ggattggtca tgtgaaaagg gctacatttg ggaagctggg     4493

aaaggcctcc aggcttctag agcagctagc ttgggctgga ttctcatacc caggctgccc     4553

cttggattgt tctacccaag cttttccctg gggtctgggc tcactccata aggtaaggtg     4613

ccttttacct tatggtcctt ctttagcagg taacaaagga gcatcagggg caggctgccc     4673

tggtggcatc acactggcta gtgaggccgt gaatatcttg tcccccagca gggccgacag     4733

tttctatcac agaaaacagt gtgttcagtg gtgaaaatcg ttgcatgcat gttttcatct     4793

gagcgtgtcc ttctcccata ctccctatca gccagccctg cctgtagctg ctgtatggtg     4853

attgcacttg gacatcagtc caatgactgc aagtcggcct ggattttcac ttgcagaggc     4913

tacagctgca ttgtcaggtc tcccagccct gcagagagct ccctccactg gttagcagtg     4973

tgttgtgttt tccattcatt tcagaagagc tacattgtgt cactggacat ttttaaaaac     5033

tgtgattttt aataaaaatt taaaatttgc tttgtgatga aaaaaa                    5079


<210>  12
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe 
1               5                   10                  15      


Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly 
            20                  25                  30          


Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu 
        35                  40                  45              


Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr 
    50                  55                  60                  


Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg 
65                  70                  75                  80  


Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser 
                85                  90                  95      


Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly 
            100                 105                 110         


Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile 
        115                 120                 125             


Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu 
    130                 135                 140                 


Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr 
145                 150                 155                 160 


Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu 
                165                 170                 175     


Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe 
            180                 185                 190         


Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu 
        195                 200                 205             


His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu 
225                 230                 235                 240 


Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr 
                245                 250                 255     


Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly 
            260                 265                 270         


Arg Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly 
        275                 280                 285             


Ile Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg 
    290                 295                 300                 


Lys Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe 
305                 310                 315                 320 


Asn Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro 
                325                 330                 335     


Gln Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr 
            340                 345                 350         


Ala Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys 
        355                 360                 365             


Leu Leu Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr 
    370                 375                 380                 


Val Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala 
385                 390                 395                 400 


Val Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu 
                405                 410                 415     


Leu Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile 
            420                 425                 430         


Val Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met 
        435                 440                 445             


Glu Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg 
    450                 455                 460                 


His Val Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met 
465                 470                 475                 480 


Gly Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala 
                485                 490                 495     


Ala Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp 
            500                 505                 510         


Phe Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala 
        515                 520                 525             


Gln Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile 
    530                 535                 540                 


Asn Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val 
545                 550                 555                 560 


Leu Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met 
                565                 570                 575     


Lys Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly 
            580                 585                 590         


Cys Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys 
        595                 600                 605             


Trp Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu 
    610                 615                 620                 


Arg Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn 
625                 630                 635 


<210>  13
<211>  683
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (105)..(365)

<400>  13
ggagggaact gtggtcaggg aactgttcgt gggcacagct gcgcagttct gtcagcgcag       60

cgcgatcacc agctcccagc gccgcagccc ccagcgcacc cagg atg atc tca gcc       116
                                                 Met Ile Ser Ala          
                                                 1                        

gtg atc ttg ttc ttg ctc ctt ttg gtg gaa caa gca gcc gcc ctg gga        164
Val Ile Leu Phe Leu Leu Leu Leu Val Glu Gln Ala Ala Ala Leu Gly           
5                   10                  15                  20            

gag ccg cag ctc tgc tat atc ctg gat gct gtc ctg ttt ttg tat ggt        212
Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly           
                25                  30                  35                

att gtc ctt acc cta ctc tac tgt cga ctc aag atc cag gtc cga aag        260
Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys           
            40                  45                  50                    

gca gct ata gcc agc cgt gag aaa gca gat gct gtc tac acg ggc ctg        308
Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu           
        55                  60                  65                        

aac acc cgg agc cag gag aca tat gag act ctg aag cat gag aaa cca        356
Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro           
    70                  75                  80                            

ccc cag tag cttcagaaca gacgtgcttg gctgcattct tttcccactt                405
Pro Gln                                                                   
85                                                                        

ctaattctct ccgagccctc ttggtcacct ctgtgctttg aaggttggct gaccttattc      465

acataatgat gctagctagg ctctacatca gtgtacactg gcaggtcccc atctccgtta      525

aagacttact cactgacatt tctcttcttc cagcctcctt tgcttcattt ctttttcctt      585

ccctgatcct cgactctcac taaacaatgg aaagggatta tcccccaata aagctgccag      645

agacctgact caaaaaaaaa aaaaaaaaaa aaaaaaaa                              683


<210>  14
<211>  86
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ile Ser Ala Val Ile Leu Phe Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Val Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val 
    50                  55                  60                  


Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  15
<211>  591
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (26)..(286)

<400>  15
cagaacggcc gatctccagc ccaag atg att cca gca gtg gtc ttg ctc tta         52
                            Met Ile Pro Ala Val Val Leu Leu Leu           
                            1               5                             

ctc ctt ttg gtt gaa caa gca gcg gcc ctg gga gag cct cag ctc tgc        100
Leu Leu Leu Val Glu Gln Ala Ala Ala Leu Gly Glu Pro Gln Leu Cys           
10                  15                  20                  25            

tat atc ctg gat gcc atc ctg ttt ctg tat gga att gtc ctc acc ctc        148
Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu           
                30                  35                  40                

ctc tac tgt cga ctg aag atc caa gtg cga aag gca gct ata acc agc        196
Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser           
            45                  50                  55                    

tat gag aaa tca gat ggt gtt tac acg ggc ctg agc acc agg aac cag        244
Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln           
        60                  65                  70                        

gag act tac gag act ctg aag cat gag aaa cca cca cag tag                286
Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln                       
    75                  80                  85                            

ctttagaata gatgcggtca tattcttctt tggcttctgg ttcttccagc cctcatggtt      346

ggcatcacat atgcctgcat gccattaaca ccagctggcc ctacccctat aatgatcctg      406

tgtcctaaat taatatacac cagtggttcc tcctccctgt taaagactaa tgctcagatg      466

ctgtttacgg atatttatat tctagtctca ctctcttgtc ccacccttct tctcttcccc      526

attcccaact ccagctaaaa tatgggaagg gagaaccccc aataaaactg ccatggactg      586

gactc                                                                  591


<210>  16
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  17
<211>  5023
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (357)..(2900)

<400>  17
gcgcctccgg ggactcgcgg accgcacaga ccggccaggc gcgctgggca tgctcagtcg       60

cggggcgcca ggctcgccag tcggaagcca gtgctcagcg gagccggccg gggcgcaccg      120

agagcgcgcg gcactcgctg ctgcagcggc ggccgggccg cggcgcatcc gggcggggac      180

ccgaggcgag tcccacgcgg cgtccccgag ccgccggcag cggcgcccgc tccagaaagg      240

caaagcgaac caggggccat cagcgcgact ggcgtcggcg gggctctgac gctccgcggc      300

ggccacctca gagtcgctgc ccgccccggc cgggccgggt ccgggagccg tcggac atg      359
                                                              Met         
                                                              1           

gag ccg tgg aag cag tgc gct cag tgg ctc atc cac agc aag gtg ctg        407
Glu Pro Trp Lys Gln Cys Ala Gln Trp Leu Ile His Ser Lys Val Leu           
            5                   10                  15                    

ccc ccc aac cat cgg gtg acc tgg gac tcg gcg cag gtg ttc gac ctg        455
Pro Pro Asn His Arg Val Thr Trp Asp Ser Ala Gln Val Phe Asp Leu           
        20                  25                  30                        

gcg cag acc ctt cgc gat gga gtc ctg ctc tgc cag ctg ctc aac aac        503
Ala Gln Thr Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn Asn           
    35                  40                  45                            

ctg cgg cca cac tcc atc aat ctg aag gag atc aac ctg agg ccc cag        551
Leu Arg Pro His Ser Ile Asn Leu Lys Glu Ile Asn Leu Arg Pro Gln           
50                  55                  60                  65            

atg tcc cag ttt ctc tgt ttg aag aac atc cgg aca ttc ctg gcc gcc        599
Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Ala Ala           
                70                  75                  80                

tgc tgc gat acc ttt gga atg agg aaa agt gaa ctt ttt gag gca ttt        647
Cys Cys Asp Thr Phe Gly Met Arg Lys Ser Glu Leu Phe Glu Ala Phe           
            85                  90                  95                    

gac cta ttt gat gtt cga gac ttt gga aag gtt ata gaa aca tta tct        695
Asp Leu Phe Asp Val Arg Asp Phe Gly Lys Val Ile Glu Thr Leu Ser           
        100                 105                 110                       

cgg cta tcc cga aca cca ata gca ttg gcc aca gga atc agg ccg ttc        743
Arg Leu Ser Arg Thr Pro Ile Ala Leu Ala Thr Gly Ile Arg Pro Phe           
    115                 120                 125                           

ccc act gaa gaa agt ata aat gat gaa gac atc tac aaa ggc ctt ccc        791
Pro Thr Glu Glu Ser Ile Asn Asp Glu Asp Ile Tyr Lys Gly Leu Pro           
130                 135                 140                 145           

gac tta ata gat gaa acc cgc gtg gaa gat gaa gaa gac ctc tat gac        839
Asp Leu Ile Asp Glu Thr Arg Val Glu Asp Glu Glu Asp Leu Tyr Asp           
                150                 155                 160               

tgt gtg tac ggc gag gat gaa ggc gga gaa gtc tat gaa gac ttg atg        887
Cys Val Tyr Gly Glu Asp Glu Gly Gly Glu Val Tyr Glu Asp Leu Met           
            165                 170                 175                   

aag gcg gag gaa gcc cag caa cct aaa tca caa gaa aat gat ata cgg        935
Lys Ala Glu Glu Ala Gln Gln Pro Lys Ser Gln Glu Asn Asp Ile Arg           
        180                 185                 190                       

agt tgt tgc cta gca gaa att agg cag aca gaa gaa aaa tac aca gaa        983
Ser Cys Cys Leu Ala Glu Ile Arg Gln Thr Glu Glu Lys Tyr Thr Glu           
    195                 200                 205                           

acg ttg gag tca ata gaa aaa tat ttc atg gca cca ttg aaa aga ttt       1031
Thr Leu Glu Ser Ile Glu Lys Tyr Phe Met Ala Pro Leu Lys Arg Phe           
210                 215                 220                 225           

ctg acg gcg gcg gaa ttt gat tca gta ttt att aac att cct gac ctt       1079
Leu Thr Ala Ala Glu Phe Asp Ser Val Phe Ile Asn Ile Pro Asp Leu           
                230                 235                 240               

gta aaa gtt cat cgg agc tta atg caa gag att cat gat tcc att gta       1127
Val Lys Val His Arg Ser Leu Met Gln Glu Ile His Asp Ser Ile Val           
            245                 250                 255                   

aat aaa gat gac cag aac ttg tat caa gtt ttt att aac tac aag gaa       1175
Asn Lys Asp Asp Gln Asn Leu Tyr Gln Val Phe Ile Asn Tyr Lys Glu           
        260                 265                 270                       

aga ttg gtt att tat ggg cag tac tgc agt gga gtg gag tca gcc atc       1223
Arg Leu Val Ile Tyr Gly Gln Tyr Cys Ser Gly Val Glu Ser Ala Ile           
    275                 280                 285                           

tct aac cta gac tac atc tct aag aca aaa gaa gat gtc aaa ctg aaa       1271
Ser Asn Leu Asp Tyr Ile Ser Lys Thr Lys Glu Asp Val Lys Leu Lys           
290                 295                 300                 305           

tta gag gaa tgt tca aaa aga gcc aat aac ggg aag ttt act ctg cgc       1319
Leu Glu Glu Cys Ser Lys Arg Ala Asn Asn Gly Lys Phe Thr Leu Arg           
                310                 315                 320               

gat ttg ctg gtc gtt cca atg cag cgc gtg ctg aag tat cac ctc ctc       1367
Asp Leu Leu Val Val Pro Met Gln Arg Val Leu Lys Tyr His Leu Leu           
            325                 330                 335                   

ctt cag gag ctg gta aaa cac acc cat gac cct atg gag aag gcg aac       1415
Leu Gln Glu Leu Val Lys His Thr His Asp Pro Met Glu Lys Ala Asn           
        340                 345                 350                       

ctg aag ctg gct ctg gat gca atg aag gac ttg gca caa tat gtg aat       1463
Leu Lys Leu Ala Leu Asp Ala Met Lys Asp Leu Ala Gln Tyr Val Asn           
    355                 360                 365                           

gaa gta aaa aga gat aat gag acc ctt cgt gaa att aag cag ttt cag       1511
Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Glu Ile Lys Gln Phe Gln           
370                 375                 380                 385           

cta tct ata gag aat ttg aac cag cca gtt ttg ctc ttt gga cga cca       1559
Leu Ser Ile Glu Asn Leu Asn Gln Pro Val Leu Leu Phe Gly Arg Pro           
                390                 395                 400               

cag gga gac ggt gaa atc cga ata acc act ctg gac aag cat aca aaa       1607
Gln Gly Asp Gly Glu Ile Arg Ile Thr Thr Leu Asp Lys His Thr Lys           
            405                 410                 415                   

caa gaa agg cat atc ttc tta ttc gac ttg gca gtg att gtc tgt aaa       1655
Gln Glu Arg His Ile Phe Leu Phe Asp Leu Ala Val Ile Val Cys Lys           
        420                 425                 430                       

agg aaa ggc gat aac tac gag atg aag gaa ata ata gat ctc cag cag       1703
Arg Lys Gly Asp Asn Tyr Glu Met Lys Glu Ile Ile Asp Leu Gln Gln           
    435                 440                 445                           

tac aag ata gcc aac aac cct acc act gac aaa gag aat aaa aag tgg       1751
Tyr Lys Ile Ala Asn Asn Pro Thr Thr Asp Lys Glu Asn Lys Lys Trp           
450                 455                 460                 465           

tct tat ggc ttc tac ctc atc cat acc caa gga caa aat ggg tta gaa       1799
Ser Tyr Gly Phe Tyr Leu Ile His Thr Gln Gly Gln Asn Gly Leu Glu           
                470                 475                 480               

ttt tat tgc aaa aca aaa gat tta aag aaa aaa tgg ctg gaa cag ttt       1847
Phe Tyr Cys Lys Thr Lys Asp Leu Lys Lys Lys Trp Leu Glu Gln Phe           
            485                 490                 495                   

gaa atg gct cta tcc aac ata agg cca gac tat gca gac tcc aat ttc       1895
Glu Met Ala Leu Ser Asn Ile Arg Pro Asp Tyr Ala Asp Ser Asn Phe           
        500                 505                 510                       

cat gat ttc aag atg cac acc ttc act cgg gtg aca tcc tgc agg gtc       1943
His Asp Phe Lys Met His Thr Phe Thr Arg Val Thr Ser Cys Arg Val           
    515                 520                 525                           

tgc cag atg ctc ctg agg gga aca ttt tat caa ggc tac tta tgt ttt       1991
Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr Leu Cys Phe           
530                 535                 540                 545           

aag tgt gga gca aaa gca cat aaa gaa tgt ttg gga aga gta gac aat       2039
Lys Cys Gly Ala Lys Ala His Lys Glu Cys Leu Gly Arg Val Asp Asn           
                550                 555                 560               

tgt ggc aga gtt aat tcc gtt gaa caa ggg cca ttc aaa cca cca gag       2087
Cys Gly Arg Val Asn Ser Val Glu Gln Gly Pro Phe Lys Pro Pro Glu           
            565                 570                 575                   

aaa cgg acc aat gga ctt cgg aga gct tcc aga cag gtg gac cca ggt       2135
Lys Arg Thr Asn Gly Leu Arg Arg Ala Ser Arg Gln Val Asp Pro Gly           
        580                 585                 590                       

ttg ccg aag atg cag gtc att agg aac tac act ggc acc ccg gcc cca       2183
Leu Pro Lys Met Gln Val Ile Arg Asn Tyr Thr Gly Thr Pro Ala Pro           
    595                 600                 605                           

ggg ctt cat gaa gga cca cca ttg cat atc cag gca ggc gac act gtt       2231
Gly Leu His Glu Gly Pro Pro Leu His Ile Gln Ala Gly Asp Thr Val           
610                 615                 620                 625           

gaa ctt ctg aga gga gat gca cac agt gtg ttc tgg cag gga cga aac       2279
Glu Leu Leu Arg Gly Asp Ala His Ser Val Phe Trp Gln Gly Arg Asn           
                630                 635                 640               

tta gct tca gga gag gtt gga ttt ttc cca agt gat gct gtc aaa ccc       2327
Leu Ala Ser Gly Glu Val Gly Phe Phe Pro Ser Asp Ala Val Lys Pro           
            645                 650                 655                   

tct cca tgt gta cct aaa cca gta gat tat tct tgc caa ccc tgg tat       2375
Ser Pro Cys Val Pro Lys Pro Val Asp Tyr Ser Cys Gln Pro Trp Tyr           
        660                 665                 670                       

gct ggc cca atg gaa aga ttg cag gca gaa act gaa ctt att aac agg       2423
Ala Gly Pro Met Glu Arg Leu Gln Ala Glu Thr Glu Leu Ile Asn Arg           
    675                 680                 685                           

gtg aat agt act tac ctt gta agg cac agg acc aaa gaa tct gga gaa       2471
Val Asn Ser Thr Tyr Leu Val Arg His Arg Thr Lys Glu Ser Gly Glu           
690                 695                 700                 705           

tat gca att agc att aag tac aat aat gaa gca aaa cac atc aag att       2519
Tyr Ala Ile Ser Ile Lys Tyr Asn Asn Glu Ala Lys His Ile Lys Ile           
                710                 715                 720               

tta aca aga gat ggc ttt ttt cac att gca gaa aat aga aaa ttt aaa       2567
Leu Thr Arg Asp Gly Phe Phe His Ile Ala Glu Asn Arg Lys Phe Lys           
            725                 730                 735                   

agc tta atg gaa ctt gtg gag tac tac aag cac cat tct ctc aaa gaa       2615
Ser Leu Met Glu Leu Val Glu Tyr Tyr Lys His His Ser Leu Lys Glu           
        740                 745                 750                       

ggg ttc agg acc tta gat aca acg cta cag ttt cca tac aag gag cca       2663
Gly Phe Arg Thr Leu Asp Thr Thr Leu Gln Phe Pro Tyr Lys Glu Pro           
    755                 760                 765                           

gaa cag cca gct gga cag agg ggt aat aga aca ggc aac agc ttg ttg       2711
Glu Gln Pro Ala Gly Gln Arg Gly Asn Arg Thr Gly Asn Ser Leu Leu           
770                 775                 780                 785           

agt ccc aaa gta ctg ggt att gcc atc gct cgg tac gac ttc tgt gca       2759
Ser Pro Lys Val Leu Gly Ile Ala Ile Ala Arg Tyr Asp Phe Cys Ala           
                790                 795                 800               

aga gat atg cgg gag ctc tcc cta ttg aaa gga gac atg gtg aag att       2807
Arg Asp Met Arg Glu Leu Ser Leu Leu Lys Gly Asp Met Val Lys Ile           
            805                 810                 815                   

tac acg aag atg agt gca aat ggc tgg tgg aga ggt gaa gta aat ggc       2855
Tyr Thr Lys Met Ser Ala Asn Gly Trp Trp Arg Gly Glu Val Asn Gly           
        820                 825                 830                       

agg gtg ggc tgg ttt cca tcc aca tat gtg gaa gaa gat gaa taa           2900
Arg Val Gly Trp Phe Pro Ser Thr Tyr Val Glu Glu Asp Glu                   
    835                 840                 845                           

agtcctatcc agtgttgacc ctgcactaaa atctcaaaga caacataagc agaagcctgc     2960

acggcattga gttaactgaa gtgtttaaaa agcagcgttc ttggctgttc aacaccctct     3020

ttttttctct tcctaagtct taatgctggg atttctaaag atgctggtac tgacagatta     3080

atggctcgcc tagagcagtg caagaaacag cctgccagtc tgtcattgtc aggaaccagg     3140

gcaaaaccaa tggcttttct acccccaaag agtccagcaa acccatcagt ttagctttct     3200

cttacttcat tgggccagac accatggatc cagccattag gaaacgcttt ttgcatattt     3260

actttgttct cacagttttt gatgatacaa agaaacagaa gtttaatttt gcttttcccc     3320

agcatgaaga gaaagtagag cctgccatct gggaaagatc cagcttgctg gaaagatcca     3380

gcatttctcg tcttaaattg ttcaacaggt gactcactgc ctggcaaacc cttttatccc     3440

cagatgttac tcatgataac aaaaaagagg ctcatgctca ggtttgcatc ataagtgata     3500

aattacagag agggttttaa ttattcattt gatgtcctga ttatatttcc acacttcttt     3560

atgaagaaga aaaagagaag cacatgaaag gaggtgtctt tgtgttaaag cttcacagct     3620

ttcgtgattt cgtggagtgt tttggaaatg tcgtgcttga caaagggaat catggccggc     3680

cagatcatgc ttagttgcca ggaatcccag aaaggtagag gtgtttacag agacagatca     3740

agcactgtaa tcaatccaca ggacatcact gtatagctgc aatagctatt aacacaagcc     3800

ttttccttct ctctagaagg acccagggca gatttgctga tttacaatct tttttttttt     3860

ttaatagtag cacaaaagag ctttattgag gatttgggaa gaaaggcagc ccgagtcctt     3920

catttctttc tgagacggat ggaagggcac ctgatgtccg tgtcctcctg cctgctctgt     3980

tggtccttct gatgcctttc tagctatgtc ttaatcagta ggaagatcca ccttgcagca     4040

tgtttctttc tctaagcttt cactgtgttc catgaggagt cttcagtatc ttcctcctga     4100

gatgcatggg gtccctagcc caggctgaca actcggctct tccatggtgg agtgtttctt     4160

tggtagcagt agctgtgttc tgacaagctt ctgaaaatgt ttcttcttgg ggaaaaaaaa     4220

gatgtatttt tatcttacaa gtgatctaga agcttctctt gtaccagact ttcttggtca     4280

cctcttacat gtaagggctg agacaacctg ttctctccca tctcacagga gtgccagaac     4340

ctggaagaga ccccatgggg gctaggactt ctcatttaaa tagactcaag acctttacct     4400

cagaattatg taaactgtga ttgtgtttta gaacaattga gcttttgtat gtgtgtaaat     4460

ggtcaggaaa atgtatttta taaaatgtct atagagtcaa cttgtgctgg caaggtctac     4520

tcttggaatg gattcctacc tataaggtct tacttgtgtc ttggggatgt tttgtctgtt     4580

catgccagca agtgttgcta tggagagtac agcttcccac agattgtaac actcctgtgt     4640

acagtattgt agcatgtatt gtttatttca gtcaatagac tccctgcctc acaaatggta     4700

tgtggtcttc ctgttgcatt tcattggcct cagagtttca tagcagagga tacagagcct     4760

cttttcatga cattaccaat gacaactttg tctacattta atactttata ttggaggttt     4820

taaatgccac gatctgtgta gatttctaat accaaagaca gacataaatg ttttccatag     4880

actttgtctt gcctgtctgt agcccttgtg tcatatggtg agttagaatg acattttact     4940

ttgtaatatt ttgtaaatat gtcaataaaa tagttactac ttgcaaaaaa aaaaaaaaaa     5000

aaaaaaaaaa aaaaaaaaaa aaa                                             5023


<210>  18
<211>  847
<212>  PRT
<213>  Mus musculus

<400>  18

Met Glu Pro Trp Lys Gln Cys Ala Gln Trp Leu Ile His Ser Lys Val 
1               5                   10                  15      


Leu Pro Pro Asn His Arg Val Thr Trp Asp Ser Ala Gln Val Phe Asp 
            20                  25                  30          


Leu Ala Gln Thr Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn 
        35                  40                  45              


Asn Leu Arg Pro His Ser Ile Asn Leu Lys Glu Ile Asn Leu Arg Pro 
    50                  55                  60                  


Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Ala 
65                  70                  75                  80  


Ala Cys Cys Asp Thr Phe Gly Met Arg Lys Ser Glu Leu Phe Glu Ala 
                85                  90                  95      


Phe Asp Leu Phe Asp Val Arg Asp Phe Gly Lys Val Ile Glu Thr Leu 
            100                 105                 110         


Ser Arg Leu Ser Arg Thr Pro Ile Ala Leu Ala Thr Gly Ile Arg Pro 
        115                 120                 125             


Phe Pro Thr Glu Glu Ser Ile Asn Asp Glu Asp Ile Tyr Lys Gly Leu 
    130                 135                 140                 


Pro Asp Leu Ile Asp Glu Thr Arg Val Glu Asp Glu Glu Asp Leu Tyr 
145                 150                 155                 160 


Asp Cys Val Tyr Gly Glu Asp Glu Gly Gly Glu Val Tyr Glu Asp Leu 
                165                 170                 175     


Met Lys Ala Glu Glu Ala Gln Gln Pro Lys Ser Gln Glu Asn Asp Ile 
            180                 185                 190         


Arg Ser Cys Cys Leu Ala Glu Ile Arg Gln Thr Glu Glu Lys Tyr Thr 
        195                 200                 205             


Glu Thr Leu Glu Ser Ile Glu Lys Tyr Phe Met Ala Pro Leu Lys Arg 
    210                 215                 220                 


Phe Leu Thr Ala Ala Glu Phe Asp Ser Val Phe Ile Asn Ile Pro Asp 
225                 230                 235                 240 


Leu Val Lys Val His Arg Ser Leu Met Gln Glu Ile His Asp Ser Ile 
                245                 250                 255     


Val Asn Lys Asp Asp Gln Asn Leu Tyr Gln Val Phe Ile Asn Tyr Lys 
            260                 265                 270         


Glu Arg Leu Val Ile Tyr Gly Gln Tyr Cys Ser Gly Val Glu Ser Ala 
        275                 280                 285             


Ile Ser Asn Leu Asp Tyr Ile Ser Lys Thr Lys Glu Asp Val Lys Leu 
    290                 295                 300                 


Lys Leu Glu Glu Cys Ser Lys Arg Ala Asn Asn Gly Lys Phe Thr Leu 
305                 310                 315                 320 


Arg Asp Leu Leu Val Val Pro Met Gln Arg Val Leu Lys Tyr His Leu 
                325                 330                 335     


Leu Leu Gln Glu Leu Val Lys His Thr His Asp Pro Met Glu Lys Ala 
            340                 345                 350         


Asn Leu Lys Leu Ala Leu Asp Ala Met Lys Asp Leu Ala Gln Tyr Val 
        355                 360                 365             


Asn Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Glu Ile Lys Gln Phe 
    370                 375                 380                 


Gln Leu Ser Ile Glu Asn Leu Asn Gln Pro Val Leu Leu Phe Gly Arg 
385                 390                 395                 400 


Pro Gln Gly Asp Gly Glu Ile Arg Ile Thr Thr Leu Asp Lys His Thr 
                405                 410                 415     


Lys Gln Glu Arg His Ile Phe Leu Phe Asp Leu Ala Val Ile Val Cys 
            420                 425                 430         


Lys Arg Lys Gly Asp Asn Tyr Glu Met Lys Glu Ile Ile Asp Leu Gln 
        435                 440                 445             


Gln Tyr Lys Ile Ala Asn Asn Pro Thr Thr Asp Lys Glu Asn Lys Lys 
    450                 455                 460                 


Trp Ser Tyr Gly Phe Tyr Leu Ile His Thr Gln Gly Gln Asn Gly Leu 
465                 470                 475                 480 


Glu Phe Tyr Cys Lys Thr Lys Asp Leu Lys Lys Lys Trp Leu Glu Gln 
                485                 490                 495     


Phe Glu Met Ala Leu Ser Asn Ile Arg Pro Asp Tyr Ala Asp Ser Asn 
            500                 505                 510         


Phe His Asp Phe Lys Met His Thr Phe Thr Arg Val Thr Ser Cys Arg 
        515                 520                 525             


Val Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr Leu Cys 
    530                 535                 540                 


Phe Lys Cys Gly Ala Lys Ala His Lys Glu Cys Leu Gly Arg Val Asp 
545                 550                 555                 560 


Asn Cys Gly Arg Val Asn Ser Val Glu Gln Gly Pro Phe Lys Pro Pro 
                565                 570                 575     


Glu Lys Arg Thr Asn Gly Leu Arg Arg Ala Ser Arg Gln Val Asp Pro 
            580                 585                 590         


Gly Leu Pro Lys Met Gln Val Ile Arg Asn Tyr Thr Gly Thr Pro Ala 
        595                 600                 605             


Pro Gly Leu His Glu Gly Pro Pro Leu His Ile Gln Ala Gly Asp Thr 
    610                 615                 620                 


Val Glu Leu Leu Arg Gly Asp Ala His Ser Val Phe Trp Gln Gly Arg 
625                 630                 635                 640 


Asn Leu Ala Ser Gly Glu Val Gly Phe Phe Pro Ser Asp Ala Val Lys 
                645                 650                 655     


Pro Ser Pro Cys Val Pro Lys Pro Val Asp Tyr Ser Cys Gln Pro Trp 
            660                 665                 670         


Tyr Ala Gly Pro Met Glu Arg Leu Gln Ala Glu Thr Glu Leu Ile Asn 
        675                 680                 685             


Arg Val Asn Ser Thr Tyr Leu Val Arg His Arg Thr Lys Glu Ser Gly 
    690                 695                 700                 


Glu Tyr Ala Ile Ser Ile Lys Tyr Asn Asn Glu Ala Lys His Ile Lys 
705                 710                 715                 720 


Ile Leu Thr Arg Asp Gly Phe Phe His Ile Ala Glu Asn Arg Lys Phe 
                725                 730                 735     


Lys Ser Leu Met Glu Leu Val Glu Tyr Tyr Lys His His Ser Leu Lys 
            740                 745                 750         


Glu Gly Phe Arg Thr Leu Asp Thr Thr Leu Gln Phe Pro Tyr Lys Glu 
        755                 760                 765             


Pro Glu Gln Pro Ala Gly Gln Arg Gly Asn Arg Thr Gly Asn Ser Leu 
    770                 775                 780                 


Leu Ser Pro Lys Val Leu Gly Ile Ala Ile Ala Arg Tyr Asp Phe Cys 
785                 790                 795                 800 


Ala Arg Asp Met Arg Glu Leu Ser Leu Leu Lys Gly Asp Met Val Lys 
                805                 810                 815     


Ile Tyr Thr Lys Met Ser Ala Asn Gly Trp Trp Arg Gly Glu Val Asn 
            820                 825                 830         


Gly Arg Val Gly Trp Phe Pro Ser Thr Tyr Val Glu Glu Asp Glu 
        835                 840                 845         


<210>  19
<211>  4776
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (55)..(2598)

<400>  19
cggccgcatc cttgccgccc gccccggccc agccgcgtcc cggagccgtc gggc atg         57
                                                            Met           
                                                            1             

gag ccg tgg aag cag tgc gcg cag tgg ctc atc cat tgc aag gtg ctg        105
Glu Pro Trp Lys Gln Cys Ala Gln Trp Leu Ile His Cys Lys Val Leu           
            5                   10                  15                    

ccc acc aac cac cgg gtg acc tgg gac tcg gct cag gtg ttc gac ctt        153
Pro Thr Asn His Arg Val Thr Trp Asp Ser Ala Gln Val Phe Asp Leu           
        20                  25                  30                        

gcg cag acc ctc cgc gat gga gtc ctg ctc tgc cag ctg ctt aac aac        201
Ala Gln Thr Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn Asn           
    35                  40                  45                            

ctc cgg gcg cac tcc atc aac ctg aag gag atc aac ctg agg ccg cag        249
Leu Arg Ala His Ser Ile Asn Leu Lys Glu Ile Asn Leu Arg Pro Gln           
50                  55                  60                  65            

atg tcc cag ttt ctc tgt ttg aag aac ata agg aca ttt ctc acg gcc        297
Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Thr Ala           
                70                  75                  80                

tgt tgt gag acg ttt gga atg agg aaa agt gaa ctt ttc gag gca ttt        345
Cys Cys Glu Thr Phe Gly Met Arg Lys Ser Glu Leu Phe Glu Ala Phe           
            85                  90                  95                    

gac ttg ttt gat gtt cgt gac ttt gga aag gtt ata gaa aca tta tca        393
Asp Leu Phe Asp Val Arg Asp Phe Gly Lys Val Ile Glu Thr Leu Ser           
        100                 105                 110                       

cga ctt tct cga aca cct ata gca ttg gcc aca gga atc agg ccc ttc        441
Arg Leu Ser Arg Thr Pro Ile Ala Leu Ala Thr Gly Ile Arg Pro Phe           
    115                 120                 125                           

cca aca gaa gaa agc att aat gat gaa gac atc tac aaa ggc ctt cct        489
Pro Thr Glu Glu Ser Ile Asn Asp Glu Asp Ile Tyr Lys Gly Leu Pro           
130                 135                 140                 145           

gat tta ata gat gaa acc ctt gtg gaa gat gaa gaa gat ctc tat gac        537
Asp Leu Ile Asp Glu Thr Leu Val Glu Asp Glu Glu Asp Leu Tyr Asp           
                150                 155                 160               

tgt gtt tat ggg gaa gat gaa ggt gga gaa gtc tat gag gac tta atg        585
Cys Val Tyr Gly Glu Asp Glu Gly Gly Glu Val Tyr Glu Asp Leu Met           
            165                 170                 175                   

aag gca gag gaa gca cat cag ccc aaa tgt cca gaa aat gat ata cga        633
Lys Ala Glu Glu Ala His Gln Pro Lys Cys Pro Glu Asn Asp Ile Arg           
        180                 185                 190                       

agt tgt tgt cta gca gaa att aag cag aca gaa gaa aaa tat aca gaa        681
Ser Cys Cys Leu Ala Glu Ile Lys Gln Thr Glu Glu Lys Tyr Thr Glu           
    195                 200                 205                           

act ttg gag tca ata gaa aag tat ttc atg gca cca cta aaa aga ttt        729
Thr Leu Glu Ser Ile Glu Lys Tyr Phe Met Ala Pro Leu Lys Arg Phe           
210                 215                 220                 225           

ctg aca gca gca gaa ttt gat tca gta ttc atc aac att cct gaa ctt        777
Leu Thr Ala Ala Glu Phe Asp Ser Val Phe Ile Asn Ile Pro Glu Leu           
                230                 235                 240               

gta aaa ctt cat cgg aac cta atg caa gag att cat gat tcc att gta        825
Val Lys Leu His Arg Asn Leu Met Gln Glu Ile His Asp Ser Ile Val           
            245                 250                 255                   

aat aaa aat gac cag aac ttg tac caa gtt ttt att aac tac aag gaa        873
Asn Lys Asn Asp Gln Asn Leu Tyr Gln Val Phe Ile Asn Tyr Lys Glu           
        260                 265                 270                       

aga ttg gtt att tac ggg cag tac tgc agt gga gtg gag tca gcc atc        921
Arg Leu Val Ile Tyr Gly Gln Tyr Cys Ser Gly Val Glu Ser Ala Ile           
    275                 280                 285                           

tct agt tta gac tac att tct aag aca aaa gaa gat gtc aaa ctg aaa        969
Ser Ser Leu Asp Tyr Ile Ser Lys Thr Lys Glu Asp Val Lys Leu Lys           
290                 295                 300                 305           

tta gag gaa tgt tcc aaa aga gca aat aat ggg aaa ttt act ctt cga       1017
Leu Glu Glu Cys Ser Lys Arg Ala Asn Asn Gly Lys Phe Thr Leu Arg           
                310                 315                 320               

gac ttg ctt gtg gtt cct atg caa cgt gtt tta aag tac cac ctt ctc       1065
Asp Leu Leu Val Val Pro Met Gln Arg Val Leu Lys Tyr His Leu Leu           
            325                 330                 335                   

ctc cag gaa ctg gtc aaa cat acc act gat ccg act gag aag gca aat       1113
Leu Gln Glu Leu Val Lys His Thr Thr Asp Pro Thr Glu Lys Ala Asn           
        340                 345                 350                       

ctg aaa ctg gct ctt gat gcc atg aag gac ttg gca caa tat gtg aat       1161
Leu Lys Leu Ala Leu Asp Ala Met Lys Asp Leu Ala Gln Tyr Val Asn           
    355                 360                 365                           

gaa gtg aaa aga gat aat gag acc ctt cgt gaa att aaa cag ttt cag       1209
Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Glu Ile Lys Gln Phe Gln           
370                 375                 380                 385           

cta tct ata gag aat ttg aac caa cca gtt ttg ctt ttt gga cga cct       1257
Leu Ser Ile Glu Asn Leu Asn Gln Pro Val Leu Leu Phe Gly Arg Pro           
                390                 395                 400               

cag gga gat ggt gaa att cga ata acc act cta gac aag cat acc aaa       1305
Gln Gly Asp Gly Glu Ile Arg Ile Thr Thr Leu Asp Lys His Thr Lys           
            405                 410                 415                   

caa gaa agg cat atc ttc tta ttt gat ttg gca gtg atc gta tgt aag       1353
Gln Glu Arg His Ile Phe Leu Phe Asp Leu Ala Val Ile Val Cys Lys           
        420                 425                 430                       

aga aaa ggt gat aac tat gaa atg aag gaa ata ata gat ctt cag cag       1401
Arg Lys Gly Asp Asn Tyr Glu Met Lys Glu Ile Ile Asp Leu Gln Gln           
    435                 440                 445                           

tac aag ata gcc aat aat cct aca acc gat aaa gaa aac aaa aag tgg       1449
Tyr Lys Ile Ala Asn Asn Pro Thr Thr Asp Lys Glu Asn Lys Lys Trp           
450                 455                 460                 465           

tct tat ggc ttc tac ctc atc cat acc caa gga caa aat ggg tta gaa       1497
Ser Tyr Gly Phe Tyr Leu Ile His Thr Gln Gly Gln Asn Gly Leu Glu           
                470                 475                 480               

ttt tat tgc aaa aca aaa gat tta aag aag aaa tgg cta gaa cag ttt       1545
Phe Tyr Cys Lys Thr Lys Asp Leu Lys Lys Lys Trp Leu Glu Gln Phe           
            485                 490                 495                   

gaa atg gct ttg tct aac ata aga cca gac tat gca gac tcc aat ttc       1593
Glu Met Ala Leu Ser Asn Ile Arg Pro Asp Tyr Ala Asp Ser Asn Phe           
        500                 505                 510                       

cac gac ttc aag atg cat acc ttc act cga gtc aca tcc tgc aaa gtc       1641
His Asp Phe Lys Met His Thr Phe Thr Arg Val Thr Ser Cys Lys Val           
    515                 520                 525                           

tgc cag atg ctc ctg agg gga aca ttt tat caa ggc tat tta tgt ttt       1689
Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr Leu Cys Phe           
530                 535                 540                 545           

aag tgt gga gcg aga gca cac aaa gaa tgt ttg gga aga gta gac aat       1737
Lys Cys Gly Ala Arg Ala His Lys Glu Cys Leu Gly Arg Val Asp Asn           
                550                 555                 560               

tgt ggc aga gtt aat tct ggt gaa caa ggg aca ctc aaa cta cca gag       1785
Cys Gly Arg Val Asn Ser Gly Glu Gln Gly Thr Leu Lys Leu Pro Glu           
            565                 570                 575                   

aaa cgg acc aat gga ctg cga aga act cct aaa cag gtg gat cca ggt       1833
Lys Arg Thr Asn Gly Leu Arg Arg Thr Pro Lys Gln Val Asp Pro Gly           
        580                 585                 590                       

tta cca aag atg cag gtc att agg aac tat tct gga aca cca ccc cca       1881
Leu Pro Lys Met Gln Val Ile Arg Asn Tyr Ser Gly Thr Pro Pro Pro           
    595                 600                 605                           

gct ctg cat gaa gga ccc cct tta cag ctc cag gcc ggg gat acc gtt       1929
Ala Leu His Glu Gly Pro Pro Leu Gln Leu Gln Ala Gly Asp Thr Val           
610                 615                 620                 625           

gaa ctt ctg aaa gga gat gca cac agt ctg ttt tgg cag ggc aga aat       1977
Glu Leu Leu Lys Gly Asp Ala His Ser Leu Phe Trp Gln Gly Arg Asn           
                630                 635                 640               

tta gca tct gga gag gtt gga ttt ttt cca agt gat gca gtc aag cct       2025
Leu Ala Ser Gly Glu Val Gly Phe Phe Pro Ser Asp Ala Val Lys Pro           
            645                 650                 655                   

tgc cca tgt gtg ccc aaa cca gta gat tat tct tgc caa ccc tgg tat       2073
Cys Pro Cys Val Pro Lys Pro Val Asp Tyr Ser Cys Gln Pro Trp Tyr           
        660                 665                 670                       

gct gga gca atg gaa aga ttg caa gca gag acc gaa ctt att aat agg       2121
Ala Gly Ala Met Glu Arg Leu Gln Ala Glu Thr Glu Leu Ile Asn Arg           
    675                 680                 685                           

gta aat agt act tac ctt gtg agg cac agg acc aaa gag tca gga gaa       2169
Val Asn Ser Thr Tyr Leu Val Arg His Arg Thr Lys Glu Ser Gly Glu           
690                 695                 700                 705           

tat gca att agc att aag tac aat aat gaa gca aag cac atc aag att       2217
Tyr Ala Ile Ser Ile Lys Tyr Asn Asn Glu Ala Lys His Ile Lys Ile           
                710                 715                 720               

tta aca aga gat ggc ttt ttt cac att gca gaa aat aga aaa ttt aaa       2265
Leu Thr Arg Asp Gly Phe Phe His Ile Ala Glu Asn Arg Lys Phe Lys           
            725                 730                 735                   

agt tta atg gaa ctt gtg gag tac tac aag cat cat tct ctc aag gaa       2313
Ser Leu Met Glu Leu Val Glu Tyr Tyr Lys His His Ser Leu Lys Glu           
        740                 745                 750                       

ggg ttc aga acc tta gat aca act ctg cag ttt cca tac aag gag cca       2361
Gly Phe Arg Thr Leu Asp Thr Thr Leu Gln Phe Pro Tyr Lys Glu Pro           
    755                 760                 765                           

gaa cat tca gct gga cag agg ggt aat aga gca ggc aac agc ttg tta       2409
Glu His Ser Ala Gly Gln Arg Gly Asn Arg Ala Gly Asn Ser Leu Leu           
770                 775                 780                 785           

agt cca aaa gtg ctg ggc att gcc atc gct cgg tat gac ttc tgt gca       2457
Ser Pro Lys Val Leu Gly Ile Ala Ile Ala Arg Tyr Asp Phe Cys Ala           
                790                 795                 800               

aga gat atg aga gag ttg tcc ttg ttg aaa gga gat gtg gtg aag att       2505
Arg Asp Met Arg Glu Leu Ser Leu Leu Lys Gly Asp Val Val Lys Ile           
            805                 810                 815                   

tac aca aag atg agt gca aat ggc tgg tgg aga gga gaa gta aat ggc       2553
Tyr Thr Lys Met Ser Ala Asn Gly Trp Trp Arg Gly Glu Val Asn Gly           
        820                 825                 830                       

agg gtg ggc tgg ttt cca tcc aca tat gtg gaa gag gat gaa taa           2598
Arg Val Gly Trp Phe Pro Ser Thr Tyr Val Glu Glu Asp Glu                   
    835                 840                 845                           

attcaaatcc cgtgttgcac cctgcaccaa aaatttcaga gaagggataa atagaagcct     2658

gcacagcatc gtgaattaac tgaagtgttt aaaaagctgc atttctggct gttcaacatc     2718

ctccctcctt agcccctcct aagtcttaat gctgagattt ctaaagatgc tggtactgac     2778

agattaatgg cttgcctaga gctgtgcaag aaacagcctg ccagtctgtc attgtcaggg     2838

accagggcaa aaccaagagc tgttcttccc agaagagccc tgcaaacaca ttggttcgtg     2898

cttcccttta cttcttctgg tcagatacca tgaatgccag tcatcagtaa atcttaatac     2958

acttttgctt tattctcaca tgccattcac cagattattt gatggtacaa agaagcagaa     3018

gtgtaatttt ccttttccca gcatgacgaa aaattggagt tctgccattt gagcagctta     3078

ctggaaagat ccagccttac ttgtcttaaa ttgtccaaca aggtgactca ttgcccggca     3138

aacactttta ccctcagatg ttactcatga tattataaaa tatgaggcca gtgctcaggt     3198

ttgcatcata agtgagctat ccctgaaggg ttttaattac ttatttggtg tcctgattat     3258

atttgcaaac ttctttataa aaggtgaaaa aagcacacaa aagagagggt gtcttcatat     3318

taaaccttca caaccttcat gatttcatag gattattttg gaaatatagc acttgacttt     3378

atgaaaggat ctgggctagg tatattaagg gtagttgcca ataacctgaa gaagctggca     3438

ttgtttacag aaacagatca agggctataa tttatgtcat tttatagcag cagtatctat     3498

taatacatgc cttttcctcc catccacctc ccccgcacac acacaaagat gacctgggac     3558

atgatttttt tattcccaca ttttcttgga gcacaaacaa ctttgttgag gattttggaa     3618

ggaaagcaca actgggtcct ttattcattt ctgggacaga aagagggtca gtggactttt     3678

gtgggcctcc agcttctctc agagtctccc cctctgcagc ccatcctggg agtgtattaa     3738

ctggagggaa gatgggtctt gcagtacatt tgttttgccc agccatcact cttttttgtg     3798

aggagcctaa atacattctt cctggggtcc agagtcccca ttcaaggcag tcaagttaag     3858

acactaactt ggccctttcc tgatggaaat atttcctcca tagcagaagt tgtgttctga     3918

caagactgag agagttacat gttgggaaaa aaaagaagca ttaacttagt agaactgaac     3978

caggagcatt aagttctgaa attttgaatc atctctgaaa tgaagcaggt gtagcctgcc     4038

ctctcatcaa tccgtctggg tgccagaact caaggttcag tggacacatc cccctgttag     4098

agaccctcat gggctaggac ttttcatcta ggatagattc aagaccttta cctcagaatt     4158

atgtaaactg tgattgtgtt ttagaaaaat tattatttgc taaaaccatt taagtctttg     4218

tatatgtgta aatgatcaca aaaatgtatt ttataaaatg ttctgtacaa taaagttaca     4278

cctcaaagtg tactcttgga atggattctt tcctgtaaag tcttatctgc gactctgtct     4338

cgggaatgtt ttgtctgttg ccgtcagccg aactttgtta tggagggagc agcctcacac     4398

aagcagaaac actcctgtgg atggtattgt agcatgtatt gtttatttta gtcaatagac     4458

cctctcctta taaatggtgt ttagtcttcc tgttgcattt catgggcctg ggggtttcct     4518

agcagaggat attggagccc ctttttgtga cattaccaat tacatctttg tccacgttta     4578

atactttgtt ttggaaaatt taaatgctgc agatttgtgt agagttctaa taccaaagac     4638

agaagtaaat gttttccata tactttgtct tgcctgtatg cagccctcgt gtaatacggt     4698

gaattagagt ggtatttcac tttgtattat tttgtaaata tgtcaatata ataaatagtg     4758

actaaattga taaaaaaa                                                   4776


<210>  20
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Pro Trp Lys Gln Cys Ala Gln Trp Leu Ile His Cys Lys Val 
1               5                   10                  15      


Leu Pro Thr Asn His Arg Val Thr Trp Asp Ser Ala Gln Val Phe Asp 
            20                  25                  30          


Leu Ala Gln Thr Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn 
        35                  40                  45              


Asn Leu Arg Ala His Ser Ile Asn Leu Lys Glu Ile Asn Leu Arg Pro 
    50                  55                  60                  


Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Thr 
65                  70                  75                  80  


Ala Cys Cys Glu Thr Phe Gly Met Arg Lys Ser Glu Leu Phe Glu Ala 
                85                  90                  95      


Phe Asp Leu Phe Asp Val Arg Asp Phe Gly Lys Val Ile Glu Thr Leu 
            100                 105                 110         


Ser Arg Leu Ser Arg Thr Pro Ile Ala Leu Ala Thr Gly Ile Arg Pro 
        115                 120                 125             


Phe Pro Thr Glu Glu Ser Ile Asn Asp Glu Asp Ile Tyr Lys Gly Leu 
    130                 135                 140                 


Pro Asp Leu Ile Asp Glu Thr Leu Val Glu Asp Glu Glu Asp Leu Tyr 
145                 150                 155                 160 


Asp Cys Val Tyr Gly Glu Asp Glu Gly Gly Glu Val Tyr Glu Asp Leu 
                165                 170                 175     


Met Lys Ala Glu Glu Ala His Gln Pro Lys Cys Pro Glu Asn Asp Ile 
            180                 185                 190         


Arg Ser Cys Cys Leu Ala Glu Ile Lys Gln Thr Glu Glu Lys Tyr Thr 
        195                 200                 205             


Glu Thr Leu Glu Ser Ile Glu Lys Tyr Phe Met Ala Pro Leu Lys Arg 
    210                 215                 220                 


Phe Leu Thr Ala Ala Glu Phe Asp Ser Val Phe Ile Asn Ile Pro Glu 
225                 230                 235                 240 


Leu Val Lys Leu His Arg Asn Leu Met Gln Glu Ile His Asp Ser Ile 
                245                 250                 255     


Val Asn Lys Asn Asp Gln Asn Leu Tyr Gln Val Phe Ile Asn Tyr Lys 
            260                 265                 270         


Glu Arg Leu Val Ile Tyr Gly Gln Tyr Cys Ser Gly Val Glu Ser Ala 
        275                 280                 285             


Ile Ser Ser Leu Asp Tyr Ile Ser Lys Thr Lys Glu Asp Val Lys Leu 
    290                 295                 300                 


Lys Leu Glu Glu Cys Ser Lys Arg Ala Asn Asn Gly Lys Phe Thr Leu 
305                 310                 315                 320 


Arg Asp Leu Leu Val Val Pro Met Gln Arg Val Leu Lys Tyr His Leu 
                325                 330                 335     


Leu Leu Gln Glu Leu Val Lys His Thr Thr Asp Pro Thr Glu Lys Ala 
            340                 345                 350         


Asn Leu Lys Leu Ala Leu Asp Ala Met Lys Asp Leu Ala Gln Tyr Val 
        355                 360                 365             


Asn Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Glu Ile Lys Gln Phe 
    370                 375                 380                 


Gln Leu Ser Ile Glu Asn Leu Asn Gln Pro Val Leu Leu Phe Gly Arg 
385                 390                 395                 400 


Pro Gln Gly Asp Gly Glu Ile Arg Ile Thr Thr Leu Asp Lys His Thr 
                405                 410                 415     


Lys Gln Glu Arg His Ile Phe Leu Phe Asp Leu Ala Val Ile Val Cys 
            420                 425                 430         


Lys Arg Lys Gly Asp Asn Tyr Glu Met Lys Glu Ile Ile Asp Leu Gln 
        435                 440                 445             


Gln Tyr Lys Ile Ala Asn Asn Pro Thr Thr Asp Lys Glu Asn Lys Lys 
    450                 455                 460                 


Trp Ser Tyr Gly Phe Tyr Leu Ile His Thr Gln Gly Gln Asn Gly Leu 
465                 470                 475                 480 


Glu Phe Tyr Cys Lys Thr Lys Asp Leu Lys Lys Lys Trp Leu Glu Gln 
                485                 490                 495     


Phe Glu Met Ala Leu Ser Asn Ile Arg Pro Asp Tyr Ala Asp Ser Asn 
            500                 505                 510         


Phe His Asp Phe Lys Met His Thr Phe Thr Arg Val Thr Ser Cys Lys 
        515                 520                 525             


Val Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr Leu Cys 
    530                 535                 540                 


Phe Lys Cys Gly Ala Arg Ala His Lys Glu Cys Leu Gly Arg Val Asp 
545                 550                 555                 560 


Asn Cys Gly Arg Val Asn Ser Gly Glu Gln Gly Thr Leu Lys Leu Pro 
                565                 570                 575     


Glu Lys Arg Thr Asn Gly Leu Arg Arg Thr Pro Lys Gln Val Asp Pro 
            580                 585                 590         


Gly Leu Pro Lys Met Gln Val Ile Arg Asn Tyr Ser Gly Thr Pro Pro 
        595                 600                 605             


Pro Ala Leu His Glu Gly Pro Pro Leu Gln Leu Gln Ala Gly Asp Thr 
    610                 615                 620                 


Val Glu Leu Leu Lys Gly Asp Ala His Ser Leu Phe Trp Gln Gly Arg 
625                 630                 635                 640 


Asn Leu Ala Ser Gly Glu Val Gly Phe Phe Pro Ser Asp Ala Val Lys 
                645                 650                 655     


Pro Cys Pro Cys Val Pro Lys Pro Val Asp Tyr Ser Cys Gln Pro Trp 
            660                 665                 670         


Tyr Ala Gly Ala Met Glu Arg Leu Gln Ala Glu Thr Glu Leu Ile Asn 
        675                 680                 685             


Arg Val Asn Ser Thr Tyr Leu Val Arg His Arg Thr Lys Glu Ser Gly 
    690                 695                 700                 


Glu Tyr Ala Ile Ser Ile Lys Tyr Asn Asn Glu Ala Lys His Ile Lys 
705                 710                 715                 720 


Ile Leu Thr Arg Asp Gly Phe Phe His Ile Ala Glu Asn Arg Lys Phe 
                725                 730                 735     


Lys Ser Leu Met Glu Leu Val Glu Tyr Tyr Lys His His Ser Leu Lys 
            740                 745                 750         


Glu Gly Phe Arg Thr Leu Asp Thr Thr Leu Gln Phe Pro Tyr Lys Glu 
        755                 760                 765             


Pro Glu His Ser Ala Gly Gln Arg Gly Asn Arg Ala Gly Asn Ser Leu 
    770                 775                 780                 


Leu Ser Pro Lys Val Leu Gly Ile Ala Ile Ala Arg Tyr Asp Phe Cys 
785                 790                 795                 800 


Ala Arg Asp Met Arg Glu Leu Ser Leu Leu Lys Gly Asp Val Val Lys 
                805                 810                 815     


Ile Tyr Thr Lys Met Ser Ala Asn Gly Trp Trp Arg Gly Glu Val Asn 
            820                 825                 830         


Gly Arg Val Gly Trp Phe Pro Ser Thr Tyr Val Glu Glu Asp Glu 
        835                 840                 845         


<210>  21
<211>  5654
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (320)..(2662)

<400>  21
ggggggcggc cattctcttc tgtccaagag agcagggcag gagtgcaggg gcagtagcga       60

aagcaggctg gtgtgtcttt aaacttccgt tggctgctta gtcacagccc cctcgctttg      120

ggtgtgtcct tcgcgcgctc cctccctctt aggtcactca ctctttcaaa gcctggaata      180

aaaaccacag ccaacttccg aagcggtctc attgcccagc agcccccagc cagtgacagg      240

ttccattcac cctcgttgcc cttctcccca cgaccctttt ccagaggcga ctagatccct      300

ccgtttcatc cagcacgcc atg gac aag ttt tgg tgg cac aca gct tgg gga       352
                     Met Asp Lys Phe Trp Trp His Thr Ala Trp Gly          
                     1               5                   10               

ctt tgc ctc ttg cag ttg agc ctg gca cat cca cat cag cag atc gat        400
Leu Cys Leu Leu Gln Leu Ser Leu Ala His Pro His Gln Gln Ile Asp           
            15                  20                  25                    

ttg aat gta acc tgc cgc tac gca ggt gta ttc cat gtg gag aaa aat        448
Leu Asn Val Thr Cys Arg Tyr Ala Gly Val Phe His Val Glu Lys Asn           
        30                  35                  40                        

ggc cgc tac agt atc tcc cgg act gag gca gct gac ctc tgc cag gct        496
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Gln Ala           
    45                  50                  55                            

ttc aac agt acc tta ccc acc atg gac caa atg aag ttg gcc ctg agc        544
Phe Asn Ser Thr Leu Pro Thr Met Asp Gln Met Lys Leu Ala Leu Ser           
60                  65                  70                  75            

aag ggt ttt gaa aca tgc agg tat ggg ttc ata gaa gga aat gtg gta        592
Lys Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly Asn Val Val           
                80                  85                  90                

att ccg agg att cat ccc aac gct atc tgt gca gcc aac cac aca gga        640
Ile Pro Arg Ile His Pro Asn Ala Ile Cys Ala Ala Asn His Thr Gly           
            95                  100                 105                   

gta tat atc ctc gtc acg tcc aac acc tcc cac tat gac aca tat tgc        688
Val Tyr Ile Leu Val Thr Ser Asn Thr Ser His Tyr Asp Thr Tyr Cys           
        110                 115                 120                       

ttc aat gcc tca gcc cct cct gaa gaa gac tgt aca tca gtc aca gac        736
Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp           
    125                 130                 135                           

cta ccc aat tcc ttc gat gga ccg gtt acc ata act att gtc aac cgt        784
Leu Pro Asn Ser Phe Asp Gly Pro Val Thr Ile Thr Ile Val Asn Arg           
140                 145                 150                 155           

gat ggt act cgc tac agc aag aag ggc gag tat aga aca cac caa gaa        832
Asp Gly Thr Arg Tyr Ser Lys Lys Gly Glu Tyr Arg Thr His Gln Glu           
                160                 165                 170               

gac atc gat gct tca aac att ata gat gac gat gtc agc agc ggc tcc        880
Asp Ile Asp Ala Ser Asn Ile Ile Asp Asp Asp Val Ser Ser Gly Ser           
            175                 180                 185                   

acc atc gag aag agc acc cca gaa agc tac att ttg cac acc tac ctt        928
Thr Ile Glu Lys Ser Thr Pro Glu Ser Tyr Ile Leu His Thr Tyr Leu           
        190                 195                 200                       

cct act gaa cag cct act gga gat cag gat gac tcc ttc ttt atc cgg        976
Pro Thr Glu Gln Pro Thr Gly Asp Gln Asp Asp Ser Phe Phe Ile Arg           
    205                 210                 215                           

agc acc ttg gcc acc att gcc tca act gtg cac tca aaa agc cat gca       1024
Ser Thr Leu Ala Thr Ile Ala Ser Thr Val His Ser Lys Ser His Ala           
220                 225                 230                 235           

gca gct cag aaa caa aat aat tgg ata tgg tct tgg ttt ggt aat tca       1072
Ala Ala Gln Lys Gln Asn Asn Trp Ile Trp Ser Trp Phe Gly Asn Ser           
                240                 245                 250               

cag tcc aca act cag act cag gag ccc aca acg agt gca act aca gcc       1120
Gln Ser Thr Thr Gln Thr Gln Glu Pro Thr Thr Ser Ala Thr Thr Ala           
            255                 260                 265                   

ttg atg acc acc cct gaa aca cca ccc aag agg caa gaa gcc cag aac       1168
Leu Met Thr Thr Pro Glu Thr Pro Pro Lys Arg Gln Glu Ala Gln Asn           
        270                 275                 280                       

tgg ttt tca tgg tta ttt caa cca tca gag tcc aag agt cat ctt cat       1216
Trp Phe Ser Trp Leu Phe Gln Pro Ser Glu Ser Lys Ser His Leu His           
    285                 290                 295                           

aca aca acg aag atg cct ggt acg gag tca aat acc aac cca aca ggc       1264
Thr Thr Thr Lys Met Pro Gly Thr Glu Ser Asn Thr Asn Pro Thr Gly           
300                 305                 310                 315           

tgg gag cca aat gag gaa aat gaa gat gaa aca gac aaa tac ccc agt       1312
Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Thr Asp Lys Tyr Pro Ser           
                320                 325                 330               

ttt tct gga tca ggc att gat gat gat gaa gat ttt atc tcc agt acc       1360
Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr           
            335                 340                 345                   

att gca agt act cca cgg gtt tct gcc cgc aca gaa gac aac cag gac       1408
Ile Ala Ser Thr Pro Arg Val Ser Ala Arg Thr Glu Asp Asn Gln Asp           
        350                 355                 360                       

tgg acc cag tgg aag cca aac cat tca aac cca gaa gta cta ctc cag       1456
Trp Thr Gln Trp Lys Pro Asn His Ser Asn Pro Glu Val Leu Leu Gln           
    365                 370                 375                           

aca acc acc agg atg gct gat ata gac aga atc agc acc agt gct cat       1504
Thr Thr Thr Arg Met Ala Asp Ile Asp Arg Ile Ser Thr Ser Ala His           
380                 385                 390                 395           

gga gaa aat tgg acc ccg gaa cca cag cct cct ttc aat aac cat gag       1552
Gly Glu Asn Trp Thr Pro Glu Pro Gln Pro Pro Phe Asn Asn His Glu           
                400                 405                 410               

tat cag gat gaa gag gag acc cca cat gct aca agc aca act cct aat       1600
Tyr Gln Asp Glu Glu Glu Thr Pro His Ala Thr Ser Thr Thr Pro Asn           
            415                 420                 425                   

agt aca gca gaa gca gca gct acc cag cag gag acg tgg ttt cag aac       1648
Ser Thr Ala Glu Ala Ala Ala Thr Gln Gln Glu Thr Trp Phe Gln Asn           
        430                 435                 440                       

gga tgg cag ggg aag aac ccc cct acc cca agt gaa gac tcc cat gtg       1696
Gly Trp Gln Gly Lys Asn Pro Pro Thr Pro Ser Glu Asp Ser His Val           
    445                 450                 455                           

aca gaa ggg aca act gct tcg gcc cac aac aac cat cca agt caa aga       1744
Thr Glu Gly Thr Thr Ala Ser Ala His Asn Asn His Pro Ser Gln Arg           
460                 465                 470                 475           

ata aca aca cag agt caa gag gat gtt tcc tgg aca gat ttc ttc gac       1792
Ile Thr Thr Gln Ser Gln Glu Asp Val Ser Trp Thr Asp Phe Phe Asp           
                480                 485                 490               

cca atc tca cat cca atg gga caa ggt cat caa aca gaa agc aag gat       1840
Pro Ile Ser His Pro Met Gly Gln Gly His Gln Thr Glu Ser Lys Asp           
            495                 500                 505                   

aca gac tcc agt cat agt aca acc ctt cag cct act gca gct cca aat       1888
Thr Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Ala Pro Asn           
        510                 515                 520                       

acc cat ttg gtg gaa gac ttg aac agg aca gga cca ctt tca gtg aca       1936
Thr His Leu Val Glu Asp Leu Asn Arg Thr Gly Pro Leu Ser Val Thr           
    525                 530                 535                           

act cca cag agt cat tct cag aac ttc tct aca tta cat gga gag ccg       1984
Thr Pro Gln Ser His Ser Gln Asn Phe Ser Thr Leu His Gly Glu Pro           
540                 545                 550                 555           

gaa gaa gac gaa aac cat cca aca act tct att ctg cca tct agc act       2032
Glu Glu Asp Glu Asn His Pro Thr Thr Ser Ile Leu Pro Ser Ser Thr           
                560                 565                 570               

aag agc ggc gct aaa gat gca aga aga ggt gga agt ctt ccc aca gat       2080
Lys Ser Gly Ala Lys Asp Ala Arg Arg Gly Gly Ser Leu Pro Thr Asp           
            575                 580                 585                   

aca act act tct gta gaa ggc tac acc ttt caa tac cca gac aca atg       2128
Thr Thr Thr Ser Val Glu Gly Tyr Thr Phe Gln Tyr Pro Asp Thr Met           
        590                 595                 600                       

gaa aat ggg act ctc ttc cca gtg acc cct gct aaa act gag gtc ttt       2176
Glu Asn Gly Thr Leu Phe Pro Val Thr Pro Ala Lys Thr Glu Val Phe           
    605                 610                 615                           

gga gaa act gaa gtg act ctt gct act gac tcc aac gtt aat gtt gat       2224
Gly Glu Thr Glu Val Thr Leu Ala Thr Asp Ser Asn Val Asn Val Asp           
620                 625                 630                 635           

ggc tcc tta cca gga gat cga gac tca tcc aag gac tcc agg ggg agt       2272
Gly Ser Leu Pro Gly Asp Arg Asp Ser Ser Lys Asp Ser Arg Gly Ser           
                640                 645                 650               

tcc cgc act gtg act cat gga tcc gaa tta gct gga cac tca agt gcg       2320
Ser Arg Thr Val Thr His Gly Ser Glu Leu Ala Gly His Ser Ser Ala           
            655                 660                 665                   

aac cag gac agt gga gtg acc aca act tct ggt cct atg agg aga cct       2368
Asn Gln Asp Ser Gly Val Thr Thr Thr Ser Gly Pro Met Arg Arg Pro           
        670                 675                 680                       

cag att cca gaa tgg ctc atc atc ttg gca tct ctc ctg gca ctg gct       2416
Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala           
    685                 690                 695                           

ctg att ctt gcc gtc tgc atc gcg gtc aat agt agg aga agg tgt ggg       2464
Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly           
700                 705                 710                 715           

cag aag aaa aag ctg gtg atc aac ggt ggc aat ggg acg gtg gaa gac       2512
Gln Lys Lys Lys Leu Val Ile Asn Gly Gly Asn Gly Thr Val Glu Asp           
                720                 725                 730               

agg aaa ccc agt gag ctc aac ggg gag gcc agc aag tct cag gaa atg       2560
Arg Lys Pro Ser Glu Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met           
            735                 740                 745                   

gtg cat ttg gtg aac aag gaa cca tca gag acc ccg gac cag tgt atg       2608
Val His Leu Val Asn Lys Glu Pro Ser Glu Thr Pro Asp Gln Cys Met           
        750                 755                 760                       

aca gct gac gag acc cgg aat ctg cag agt gtg gac atg aag att ggg       2656
Thr Ala Asp Glu Thr Arg Asn Leu Gln Ser Val Asp Met Lys Ile Gly           
    765                 770                 775                           

gtg tag tgcctacgcc attaacttga aaagacagca cgattggaga cgtcattcct        2712
Val                                                                       
780                                                                       

gggagctggg accctccaca gatgcaatgt gctactgact attattattg gggattatgt     2772

ttagcataaa attttctatt ccttttttat tttatgtcat ttttttagag tctgttccaa     2832

tttatgaaaa tagcattgct ttctgaaatg agggcccaaa taatactcca ttaagaattt     2892

gacttttcca gttccttcct aggggccttg cattaccagg gtatgctacc ataggcttct     2952

accaaatgca cattcttggt ccctattgaa ccttatccct acccaaagtc ccagggaaca     3012

tccaccagct aaggattttc cccagaacct agattggtct ctgggaggaa atttgaatgg     3072

gtccatattg cctctccagc agtccaatcc ttaggcattg ctttccagcg gggtgggaga     3132

tcaggtgtac tggttacata ctctctttat agactccctt ctgctggaaa attttcagat     3192

gcttctgaga gatccccaaa gggtgatgct atttatcttt agtaagctat ttatctttgt     3252

ttttgaaata tcaaaccctg gaggtccttt gttcagtatg actttttttt ttattttgtt     3312

ttattttgtt ttgttttgtt ttgttttttt aggttacttt atcagaagca taacagggta     3372

taaattgatt cataataagt accggtccat cttccatctt gacccgttgt gctgtgatcc     3432

ttcagtttct aaacaagcaa agtctgagtc tttgtagcac atcagtgtgg ccttagtatg     3492

gtcctcctaa gctcatgcta gagcatctga gcctgctggg ttcacccagc tcaatctcat     3552

tgaagatcag ggacaggagc actgttttca ttccaggctc tcaaaggggt ttctctcctg     3612

ttcaagaatc tgaagtgaga gtaggcaagc ttcagtccct tttgtgcttt ggtgaccacc     3672

cttttctatt tcttaaagaa cacattaagt ttttatatct tacaacgttt gtggtcctgt     3732

gtcatagaga atgatcttat tagtgatttc acaaaacatt gtggtgggga cttgtggcgc     3792

cttctcataa aaggagaagc caacagaaat gaaagtgtaa acatccagca gtagcttgcc     3852

acgaggagga ggtgtgatgt acaaccccca tctcactcta gccatggctg tgtttgttgg     3912

tgctttcaca agcgagttgg tacttagaat cagttccctg gggaacccct caaaaagcca     3972

caggactgcc caccactggg atcttatcat cagataagca ggtttatggt ttagcaaaag     4032

gagaatgctg ttaccctcat agttttcaca tattgggcaa gtgttcattc atctgccagg     4092

atgtcccatt gctcctggat cttcctaggt atcttgtaga atatattaac tctataaaat     4152

aaggctgtct ctaaaatgga acttcctttc taagggtccc acttttactg ttgactaaat     4212

ttatatgttt agtaggtttt tttttccaat aaaaacaaac aaaaaaaaaa aaaggagaaa     4272

aaattttcac ctgagtcagg tttgagttta tatcaaaagt ggatgtgaag atgttcctta     4332

aaggagatac acggactttc tggcacaatt ttgagcctca gctctcctta ctcatattct     4392

agcctccctc cttccctgcc catctctccc ccagagccat ggctttcatg gactttctct     4452

ttctctgtga atactataag ccagttccat atttagacac ctggttttct tgttcaaata     4512

gacactagat gattcttggc tattctccac tggtattaga atgtcccctg tccttagagc     4572

tatcctggcc taccacaccc acaacaggct ccctggggct ctttaaccta tatgcagcaa     4632

gccactctgg gattggtcat aaaagggctc tgtcaagctc tccatgaccc cttgatgccc     4692

tttgagggca caagaagagt catacaagac tcagagctaa agataattct ctacccattc     4752

taaaaaagtc cactagttgg gttgtggtag gacattgctt gccatagtgg tgatgattct     4812

ggtagcacaa tctgactttg agttactcca tgattttgta aagtattagg agcccttaaa     4872

gtgttctttt gccatcaact ataaatttct catatatcct ggaggctttc cttctctttg     4932

ccttgggtaa aaatcaaatg aggtgaaaga taccttcatg tccatatttt gtatgttcta     4992

gctagataaa atggatgttt cagaaaagcc tttaaaaatc tttatattga catccataac     5052

accaaaaact gtctttttag ctaaaatcga cccaagactg tcacagcaaa gtagaagaaa     5112

cagccatctt ctttggaaaa gtaaaatgtt cataagaaca gggattgccc actatgatga     5172

taatgatgta ctgtgtcttt gtgtaagtcc tatgtgttga cttttcaaat atagccaatt     5232

gcttaggtat gtacaatgag tttttctatt gttcctttga tttttcagag accccccctt     5292

tctttttcca gtttttgtat atttattgat tgactaataa taatgaggaa aacctgatgt     5352

gtacattacc cgattgaaag tgtgtattgg aaaatattaa aaggttgtaa aaaatggaac     5412

ctagggtctc tggtgtgaag ggtctgggaa gtggagaggg gcagaaagtg attgtctgga     5472

tgtctgaata atatggaaga agtcagaggc agctggcatc ctttgttttg ttttgttttg     5532

ttttgttctt ttatagcccc cccctcctat ttttctttgg tgtttttgtt ttgtttgttt     5592

gatttttgaa acaggatctc atagagctca gactggtaat aaattcaata tgtagccgaa     5652

aa                                                                    5654


<210>  22
<211>  780
<212>  PRT
<213>  Mus musculus

<400>  22

Met Asp Lys Phe Trp Trp His Thr Ala Trp Gly Leu Cys Leu Leu Gln 
1               5                   10                  15      


Leu Ser Leu Ala His Pro His Gln Gln Ile Asp Leu Asn Val Thr Cys 
            20                  25                  30          


Arg Tyr Ala Gly Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile 
        35                  40                  45              


Ser Arg Thr Glu Ala Ala Asp Leu Cys Gln Ala Phe Asn Ser Thr Leu 
    50                  55                  60                  


Pro Thr Met Asp Gln Met Lys Leu Ala Leu Ser Lys Gly Phe Glu Thr 
65                  70                  75                  80  


Cys Arg Tyr Gly Phe Ile Glu Gly Asn Val Val Ile Pro Arg Ile His 
                85                  90                  95      


Pro Asn Ala Ile Cys Ala Ala Asn His Thr Gly Val Tyr Ile Leu Val 
            100                 105                 110         


Thr Ser Asn Thr Ser His Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala 
        115                 120                 125             


Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ser Phe 
    130                 135                 140                 


Asp Gly Pro Val Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr 
145                 150                 155                 160 


Ser Lys Lys Gly Glu Tyr Arg Thr His Gln Glu Asp Ile Asp Ala Ser 
                165                 170                 175     


Asn Ile Ile Asp Asp Asp Val Ser Ser Gly Ser Thr Ile Glu Lys Ser 
            180                 185                 190         


Thr Pro Glu Ser Tyr Ile Leu His Thr Tyr Leu Pro Thr Glu Gln Pro 
        195                 200                 205             


Thr Gly Asp Gln Asp Asp Ser Phe Phe Ile Arg Ser Thr Leu Ala Thr 
    210                 215                 220                 


Ile Ala Ser Thr Val His Ser Lys Ser His Ala Ala Ala Gln Lys Gln 
225                 230                 235                 240 


Asn Asn Trp Ile Trp Ser Trp Phe Gly Asn Ser Gln Ser Thr Thr Gln 
                245                 250                 255     


Thr Gln Glu Pro Thr Thr Ser Ala Thr Thr Ala Leu Met Thr Thr Pro 
            260                 265                 270         


Glu Thr Pro Pro Lys Arg Gln Glu Ala Gln Asn Trp Phe Ser Trp Leu 
        275                 280                 285             


Phe Gln Pro Ser Glu Ser Lys Ser His Leu His Thr Thr Thr Lys Met 
    290                 295                 300                 


Pro Gly Thr Glu Ser Asn Thr Asn Pro Thr Gly Trp Glu Pro Asn Glu 
305                 310                 315                 320 


Glu Asn Glu Asp Glu Thr Asp Lys Tyr Pro Ser Phe Ser Gly Ser Gly 
                325                 330                 335     


Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr Ile Ala Ser Thr Pro 
            340                 345                 350         


Arg Val Ser Ala Arg Thr Glu Asp Asn Gln Asp Trp Thr Gln Trp Lys 
        355                 360                 365             


Pro Asn His Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met 
    370                 375                 380                 


Ala Asp Ile Asp Arg Ile Ser Thr Ser Ala His Gly Glu Asn Trp Thr 
385                 390                 395                 400 


Pro Glu Pro Gln Pro Pro Phe Asn Asn His Glu Tyr Gln Asp Glu Glu 
                405                 410                 415     


Glu Thr Pro His Ala Thr Ser Thr Thr Pro Asn Ser Thr Ala Glu Ala 
            420                 425                 430         


Ala Ala Thr Gln Gln Glu Thr Trp Phe Gln Asn Gly Trp Gln Gly Lys 
        435                 440                 445             


Asn Pro Pro Thr Pro Ser Glu Asp Ser His Val Thr Glu Gly Thr Thr 
    450                 455                 460                 


Ala Ser Ala His Asn Asn His Pro Ser Gln Arg Ile Thr Thr Gln Ser 
465                 470                 475                 480 


Gln Glu Asp Val Ser Trp Thr Asp Phe Phe Asp Pro Ile Ser His Pro 
                485                 490                 495     


Met Gly Gln Gly His Gln Thr Glu Ser Lys Asp Thr Asp Ser Ser His 
            500                 505                 510         


Ser Thr Thr Leu Gln Pro Thr Ala Ala Pro Asn Thr His Leu Val Glu 
        515                 520                 525             


Asp Leu Asn Arg Thr Gly Pro Leu Ser Val Thr Thr Pro Gln Ser His 
    530                 535                 540                 


Ser Gln Asn Phe Ser Thr Leu His Gly Glu Pro Glu Glu Asp Glu Asn 
545                 550                 555                 560 


His Pro Thr Thr Ser Ile Leu Pro Ser Ser Thr Lys Ser Gly Ala Lys 
                565                 570                 575     


Asp Ala Arg Arg Gly Gly Ser Leu Pro Thr Asp Thr Thr Thr Ser Val 
            580                 585                 590         


Glu Gly Tyr Thr Phe Gln Tyr Pro Asp Thr Met Glu Asn Gly Thr Leu 
        595                 600                 605             


Phe Pro Val Thr Pro Ala Lys Thr Glu Val Phe Gly Glu Thr Glu Val 
    610                 615                 620                 


Thr Leu Ala Thr Asp Ser Asn Val Asn Val Asp Gly Ser Leu Pro Gly 
625                 630                 635                 640 


Asp Arg Asp Ser Ser Lys Asp Ser Arg Gly Ser Ser Arg Thr Val Thr 
                645                 650                 655     


His Gly Ser Glu Leu Ala Gly His Ser Ser Ala Asn Gln Asp Ser Gly 
            660                 665                 670         


Val Thr Thr Thr Ser Gly Pro Met Arg Arg Pro Gln Ile Pro Glu Trp 
        675                 680                 685             


Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val 
    690                 695                 700                 


Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu 
705                 710                 715                 720 


Val Ile Asn Gly Gly Asn Gly Thr Val Glu Asp Arg Lys Pro Ser Glu 
                725                 730                 735     


Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn 
            740                 745                 750         


Lys Glu Pro Ser Glu Thr Pro Asp Gln Cys Met Thr Ala Asp Glu Thr 
        755                 760                 765             


Arg Asn Leu Gln Ser Val Asp Met Lys Ile Gly Val 
    770                 775                 780 


<210>  23
<211>  5748
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (435)..(2663)

<400>  23
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga cacc atg gac aag ttt tgg tgg cac gca gcc tgg gga ctc        470
                Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu           
                1               5                   10                    

tgc ctc gtg ccg ctg agc ctg gcg cag atc gat ttg aat ata acc tgc        518
Cys Leu Val Pro Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys           
        15                  20                  25                        

cgc ttt gca ggt gta ttc cac gtg gag aaa aat ggt cgc tac agc atc        566
Arg Phe Ala Gly Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile           
    30                  35                  40                            

tct cgg acg gag gcc gct gac ctc tgc aag gct ttc aat agc acc ttg        614
Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu           
45                  50                  55                  60            

ccc aca atg gcc cag atg gag aaa gct ctg agc atc gga ttt gag acc        662
Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr           
                65                  70                  75                

tgc agg tat ggg ttc ata gaa ggg cac gtg gtg att ccc cgg atc cac        710
Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His           
            80                  85                  90                    

ccc aac tcc atc tgt gca gca aac aac aca ggg gtg tac atc ctc aca        758
Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr           
        95                  100                 105                       

tcc aac acc tcc cag tat gac aca tat tgc ttc aat gct tca gct cca        806
Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro           
    110                 115                 120                           

cct gaa gaa gat tgt aca tca gtc aca gac ctg ccc aat gcc ttt gat        854
Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp           
125                 130                 135                 140           

gga cca att acc ata act att gtt aac cgt gat ggc acc cgc tat gtc        902
Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val           
                145                 150                 155               

cag aaa gga gaa tac aga acg aat cct gaa gac atc tac ccc agc aac        950
Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn           
            160                 165                 170                   

cct act gat gat gac gtg agc agc ggc tcc tcc agt gaa agg agc agc        998
Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser           
        175                 180                 185                       

act tca gga ggt tac atc ttt tac acc ttt tct act gta cac ccc atc       1046
Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile           
    190                 195                 200                           

cca gac gaa gac agt ccc tgg atc acc gac agc aca gac aga atc cct       1094
Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro           
205                 210                 215                 220           

gct acc act ttg atg agc act agt gct aca gca act gag aca gca acc       1142
Ala Thr Thr Leu Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr           
                225                 230                 235               

aag agg caa gaa acc tgg gat tgg ttt tca tgg ttg ttt cta cca tca       1190
Lys Arg Gln Glu Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser           
            240                 245                 250                   

gag tca aag aat cat ctt cac aca aca aca caa atg gct ggt acg tct       1238
Glu Ser Lys Asn His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser           
        255                 260                 265                       

tca aat acc atc tca gca ggc tgg gag cca aat gaa gaa aat gaa gat       1286
Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp           
    270                 275                 280                           

gaa aga gac aga cac ctc agt ttt tct gga tca ggc att gat gat gat       1334
Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp           
285                 290                 295                 300           

gaa gat ttt atc tcc agc acc att tca acc aca cca cgg gct ttt gac       1382
Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp           
                305                 310                 315               

cac aca aaa cag aac cag gac tgg acc cag tgg aac cca agc cat tca       1430
His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser           
            320                 325                 330                   

aat ccg gaa gtg cta ctt cag aca acc aca agg atg act gat gta gac       1478
Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp           
        335                 340                 345                       

aga aat ggc acc act gct tat gaa gga aac tgg aac cca gaa gca cac       1526
Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His           
    350                 355                 360                           

cct ccc ctc att cac cat gag cat cat gag gaa gaa gag acc cca cat       1574
Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro His           
365                 370                 375                 380           

tct aca agc aca atc cag gca act cct agt agt aca acg gaa gaa aca       1622
Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr           
                385                 390                 395               

gct acc cag aag gaa cag tgg ttt ggc aac aga tgg cat gag gga tat       1670
Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr           
            400                 405                 410                   

cgc caa aca ccc aaa gaa gac tcc cat tcg aca aca ggg aca gct gca       1718
Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala           
        415                 420                 425                       

gcc tca gct cat acc agc cat cca atg caa gga agg aca aca cca agc       1766
Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser           
    430                 435                 440                           

cca gag gac agt tcc tgg act gat ttc ttc aac cca atc tca cac ccc       1814
Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro           
445                 450                 455                 460           

atg gga cga ggt cat caa gca gga aga agg atg gat atg gac tcc agt       1862
Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser           
                465                 470                 475               

cat agt ata acg ctt cag cct act gca aat cca aac aca ggt ttg gtg       1910
His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val           
            480                 485                 490                   

gaa gat ttg gac agg aca gga cct ctt tca atg aca acg cag cag agt       1958
Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser           
        495                 500                 505                       

aat tct cag agc ttc tct aca tca cat gaa ggc ttg gaa gaa gat aaa       2006
Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys           
    510                 515                 520                           

gac cat cca aca act tct act ctg aca tca agc aat agg aat gat gtc       2054
Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val           
525                 530                 535                 540           

aca ggt gga aga aga gac cca aat cat tct gaa ggc tca act act tta       2102
Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu           
                545                 550                 555               

ctg gaa ggt tat acc tct cat tac cca cac acg aag gaa agc agg acc       2150
Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr           
            560                 565                 570                   

ttc atc cca gtg acc tca gct aag act ggg tcc ttt gga gtt act gca       2198
Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala           
        575                 580                 585                       

gtt act gtt gga gat tcc aac tct aat gtc aat cgt tcc tta tca gga       2246
Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly           
    590                 595                 600                           

gac caa gac aca ttc cac ccc agt ggg ggg tcc cat acc act cat gga       2294
Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly           
605                 610                 615                 620           

tct gaa tca gat gga cac tca cat ggg agt caa gaa ggt gga gca aac       2342
Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn           
                625                 630                 635               

aca acc tct ggt cct ata agg aca ccc caa att cca gaa tgg ctg atc       2390
Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile           
            640                 645                 650                   

atc ttg gca tcc ctc ttg gcc ttg gct ttg att ctt gca gtt tgc att       2438
Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile           
        655                 660                 665                       

gca gtc aac agt cga aga agg tgt ggg cag aag aaa aag cta gtg atc       2486
Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile           
    670                 675                 680                           

aac agt ggc aat gga gct gtg gag gac aga aag cca agt gga ctc aac       2534
Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn           
685                 690                 695                 700           

gga gag gcc agc aag tct cag gaa atg gtg cat ttg gtg aac aag gag       2582
Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu           
                705                 710                 715               

tcg tca gaa act cca gac cag ttt atg aca gct gat gag aca agg aac       2630
Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn           
            720                 725                 730                   

ctg cag aat gtg gac atg aag att ggg gtg taa cacctacacc attatcttgg     2683
Leu Gln Asn Val Asp Met Lys Ile Gly Val                                   
        735                 740                                           

aaagaaacaa ccgttggaaa cataaccatt acagggagct gggacactta acagatgcaa     2743

tgtgctactg attgtttcat tgcgaatctt ttttagcata aaattttcta ctctttttgt     2803

tttttgtgtt ttgttcttta aagtcaggtc caatttgtaa aaacagcatt gctttctgaa     2863

attagggccc aattaataat cagcaagaat ttgatcgttc cagttcccac ttggaggcct     2923

ttcatccctc gggtgtgcta tggatggctt ctaacaaaaa ctacacatat gtattcctga     2983

tcgccaacct ttcccccacc agctaaggac atttcccagg gttaataggg cctggtccct     3043

gggaggaaat ttgaatgggt ccattttgcc cttccatagc ctaatccctg ggcattgctt     3103

tccactgagg ttgggggttg gggtgtacta gttacacatc ttcaacagac cccctctaga     3163

aatttttcag atgcttctgg gagacaccca aagggtgaag ctatttatct gtagtaaact     3223

atttatctgt gtttttgaaa tattaaaccc tggatcagtc ctttgatcag tataattttt     3283

taaagttact ttgtcagagg cacaaaaggg tttaaactga ttcataataa atatctgtac     3343

ttcttcgatc ttcacctttt gtgctgtgat tcttcagttt ctaaaccagc actgtctggg     3403

tccctacaat gtatcaggaa gagctgagaa tggtaaggag actcttctaa gtcttcatct     3463

cagagaccct gagttcccac tcagacccac tcagccaaat ctcatggaag accaaggagg     3523

gcagcactgt ttttgttttt tgttttttgt tttttttttt tgacactgtc caaaggtttt     3583

ccatcctgtc ctggaatcag agttggaagc tgaggagctt cagcctcttt tatggtttaa     3643

tggccacctg ttctctcctg tgaaaggctt tgcaaagtca cattaagttt gcatgacctg     3703

ttatccctgg ggccctattt catagaggct ggccctatta gtgatttcca aaaacaatat     3763

ggaagtgcct tttgatgtct tacaataaga gaagaagcca atggaaatga aagagattgg     3823

caaaggggaa ggatgatgcc atgtagatcc tgtttgacat ttttatggct gtatttgtaa     3883

acttaaacac accagtgtct gttcttgatg cagttgctat ttaggatgag ttaagtgcct     3943

ggggagtccc tcaaaaggtt aaagggattc ccatcattgg aatcttatca ccagataggc     4003

aagtttatga ccaaacaaga gagtactggc tttatcctct aacctcatat tttctcccac     4063

ttggcaagtc ctttgtggca tttattcatc agtcagggtg tccgattggt cctagaactt     4123

ccaaaggctg cttgtcatag aagccattgc atctataaag caacggctcc tgttaaatgg     4183

tatctccttt ctgaggctcc tactaaaagt catttgttac ctaaacttat gtgcttaaca     4243

ggcaatgctt ctcagaccac aaagcagaaa gaagaagaaa agctcctgac taaatcaggg     4303

ctgggcttag acagagttga tctgtagaat atctttaaag gagagatgtc aactttctgc     4363

actattccca gcctctgctc ctccctgtct accctctccc ctccctctct ccctccactt     4423

caccccacaa tcttgaaaaa cttcctttct cttctgtgaa catcattggc cagatccatt     4483

ttcagtggtc tggatttctt tttattttct tttcaacttg aaagaaactg gacattaggc     4543

cactatgtgt tgttactgcc actagtgttc aagtgcctct tgttttccca gagatttcct     4603

gggtctgcca gaggcccaga caggctcact caagctcttt aactgaaaag caacaagcca     4663

ctccaggaca aggttcaaaa tggttacaac agcctctacc tgtcgcccca gggagaaagg     4723

ggtagtgata caagtctcat agccagagat ggttttccac tccttctaga tattcccaaa     4783

aagaggctga gacaggaggt tattttcaat tttattttgg aattaaatac ttttttccct     4843

ttattactgt tgtagtccct cacttggata tacctctgtt ttcacgatag aaataaggga     4903

ggtctagagc ttctattcct tggccattgt caacggagag ctggccaagt cttcacaaac     4963

ccttgcaaca ttgcctgaag tttatggaat aagatgtatt ctcactccct tgatctcaag     5023

ggcgtaactc tggaagcaca gcttgactac acgtcatttt taccaatgat tttcaggtga     5083

cctgggctaa gtcatttaaa ctgggtcttt ataaaagtaa aaggccaaca tttaattatt     5143

ttgcaaagca acctaagagc taaagatgta atttttcttg caattgtaaa tcttttgtgt     5203

ctcctgaaga cttcccttaa aattagctct gagtgaaaaa tcaaaagaga caaaagacat     5263

cttcgaatcc atatttcaag cctggtagaa ttggcttttc tagcagaacc tttccaaaag     5323

ttttatattg agattcataa caacaccaag aattgatttt gtagccaaca ttcattcaat     5383

actgttatat cagaggagta ggagagagga aacatttgac ttatctggaa aagcaaaatg     5443

tacttaagaa taagaataac atggtccatt cacctttatg ttatagatat gtctttgtgt     5503

aaatcatttg ttttgagttt tcaaagaata gcccattgtt cattcttgtg ctgtacaatg     5563

accactgtta ttgttacttt gacttttcag agcacaccct tcctctggtt tttgtatatt     5623

tattgatgga tcaataataa tgaggaaagc atgatatgta tattgctgag ttgaaagcac     5683

ttattggaaa atattaaaag gctaacatta aaagactaaa ggaaacagaa aaaaaaaaaa     5743

aaaaa                                                                 5748


<210>  24
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  25
<211>  3185
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (7)..(2199)

<400>  25
ctcacc atg agt ccc tgg cag ccc ctg ctc ctg gct ctc ctg gct ttc          48
       Met Ser Pro Trp Gln Pro Leu Leu Leu Ala Leu Leu Ala Phe            
       1               5                   10                             

ggc tgc agc tct gct gcc cct tac cag cgc cag ccg act ttt gtg gtc         96
Gly Cys Ser Ser Ala Ala Pro Tyr Gln Arg Gln Pro Thr Phe Val Val           
15                  20                  25                  30            

ttc ccc aaa gac ctg aaa acc tcc aac ctc acg gac acc cag ctg gca        144
Phe Pro Lys Asp Leu Lys Thr Ser Asn Leu Thr Asp Thr Gln Leu Ala           
                35                  40                  45                

gag gca tac ttg tac cgc tat ggt tac acc cgg gcc gcc cag atg atg        192
Glu Ala Tyr Leu Tyr Arg Tyr Gly Tyr Thr Arg Ala Ala Gln Met Met           
            50                  55                  60                    

gga gag aag cag tct cta cgg ccg gct ttg ctg atg ctt cag aag cag        240
Gly Glu Lys Gln Ser Leu Arg Pro Ala Leu Leu Met Leu Gln Lys Gln           
        65                  70                  75                        

ctc tcc ctg ccc cag act ggt gag ctg gac agc cag aca cta aag gcc        288
Leu Ser Leu Pro Gln Thr Gly Glu Leu Asp Ser Gln Thr Leu Lys Ala           
    80                  85                  90                            

att cga aca cca cgc tgt ggt gtc cca gac gtg ggt cga ttc caa acc        336
Ile Arg Thr Pro Arg Cys Gly Val Pro Asp Val Gly Arg Phe Gln Thr           
95                  100                 105                 110           

ttc aaa ggc ctc aag tgg gac cat cat aac atc aca tac tgg atc caa        384
Phe Lys Gly Leu Lys Trp Asp His His Asn Ile Thr Tyr Trp Ile Gln           
                115                 120                 125               

aac tac tct gaa gac ttg ccg cga gac atg atc gat gac gcc ttc gcg        432
Asn Tyr Ser Glu Asp Leu Pro Arg Asp Met Ile Asp Asp Ala Phe Ala           
            130                 135                 140                   

cgc gcc ttc gcg gtg tgg ggc gag gtg gca ccc ctc acc ttc acc cgc        480
Arg Ala Phe Ala Val Trp Gly Glu Val Ala Pro Leu Thr Phe Thr Arg           
        145                 150                 155                       

gtg tac gga ccc gaa gcg gac att gtc atc cag ttt ggt gtc gcg gag        528
Val Tyr Gly Pro Glu Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu           
    160                 165                 170                           

cac gga gac ggg tat ccc ttc gac ggc aag gac ggc ctt ctg gca cac        576
His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His           
175                 180                 185                 190           

gcc ttt ccc cct ggc gcc ggc gtt cag gga gat gcc cat ttc gac gac        624
Ala Phe Pro Pro Gly Ala Gly Val Gln Gly Asp Ala His Phe Asp Asp           
                195                 200                 205               

gac gag ttg tgg tcg ctg ggc aaa ggc gtc gtg atc ccc act tac tat        672
Asp Glu Leu Trp Ser Leu Gly Lys Gly Val Val Ile Pro Thr Tyr Tyr           
            210                 215                 220                   

gga aac tca aat ggt gcc cca tgt cac ttt ccc ttc acc ttc gag gga        720
Gly Asn Ser Asn Gly Ala Pro Cys His Phe Pro Phe Thr Phe Glu Gly           
        225                 230                 235                       

cgc tcc tat tcg gcc tgc acc aca gac ggc cgc aac gac ggc acg cct        768
Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Asn Asp Gly Thr Pro           
    240                 245                 250                           

tgg tgt agc aca aca gct gac tac gat aag gac ggc aaa ttt ggt ttc        816
Trp Cys Ser Thr Thr Ala Asp Tyr Asp Lys Asp Gly Lys Phe Gly Phe           
255                 260                 265                 270           

tgc cct agt gag aga ctc tac acg gag cac ggc aac gga gaa ggc aaa        864
Cys Pro Ser Glu Arg Leu Tyr Thr Glu His Gly Asn Gly Glu Gly Lys           
                275                 280                 285               

ccc tgt gtg ttc ccg ttc atc ttt gag ggc cgc tcc tac tct gcc tgc        912
Pro Cys Val Phe Pro Phe Ile Phe Glu Gly Arg Ser Tyr Ser Ala Cys           
            290                 295                 300                   

acc act aaa ggc cgc tcg gat ggt tac cgc tgg tgc gcc acc aca gcc        960
Thr Thr Lys Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala           
        305                 310                 315                       

aac tat gac cag gat aaa ctg tat ggc ttc tgc cct acc cga gtg gac       1008
Asn Tyr Asp Gln Asp Lys Leu Tyr Gly Phe Cys Pro Thr Arg Val Asp           
    320                 325                 330                           

gcg acc gta gtt ggg ggc aac tcg gca gga gag ctg tgc gtc ttc ccc       1056
Ala Thr Val Val Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro           
335                 340                 345                 350           

ttc gtc ttc ctg ggc aag cag tac tct tcc tgt acc agc gac ggc cgc       1104
Phe Val Phe Leu Gly Lys Gln Tyr Ser Ser Cys Thr Ser Asp Gly Arg           
                355                 360                 365               

agg gat ggg cgc ctc tgg tgt gcg acc aca tcg aac ttc gac act gac       1152
Arg Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Thr Asp           
            370                 375                 380                   

aag aag tgg ggt ttc tgt cca gac caa ggg tac agc ctg ttc ctg gtg       1200
Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val           
        385                 390                 395                       

gca gcg cac gag ttc ggc cat gca ctg ggc tta gat cat tcc agc gtg       1248
Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val           
    400                 405                 410                           

ccg gaa gcg ctc atg tac ccg ctg tat agc tac ctc gag ggc ttc cct       1296
Pro Glu Ala Leu Met Tyr Pro Leu Tyr Ser Tyr Leu Glu Gly Phe Pro           
415                 420                 425                 430           

ctg aat aaa gac gac ata gac ggc atc cag tat ctg tat ggt cgt ggc       1344
Leu Asn Lys Asp Asp Ile Asp Gly Ile Gln Tyr Leu Tyr Gly Arg Gly           
                435                 440                 445               

tct aag cct gac cca agg cct cca gcc acc acc aca act gaa cca cag       1392
Ser Lys Pro Asp Pro Arg Pro Pro Ala Thr Thr Thr Thr Glu Pro Gln           
            450                 455                 460                   

ccg aca gca cct ccc act atg tgt ccc act ata cct ccc acg gcc tat       1440
Pro Thr Ala Pro Pro Thr Met Cys Pro Thr Ile Pro Pro Thr Ala Tyr           
        465                 470                 475                       

ccc aca gtg ggc ccc acg gtt ggc cct aca ggc gcc ccc tca cct ggc       1488
Pro Thr Val Gly Pro Thr Val Gly Pro Thr Gly Ala Pro Ser Pro Gly           
    480                 485                 490                           

ccc aca agc agc ccg tca cct ggc cct aca ggc gcc ccc tca cct ggc       1536
Pro Thr Ser Ser Pro Ser Pro Gly Pro Thr Gly Ala Pro Ser Pro Gly           
495                 500                 505                 510           

cct aca gcg ccc cct act gcg ggc tct tct gag gcc tct aca gag tct       1584
Pro Thr Ala Pro Pro Thr Ala Gly Ser Ser Glu Ala Ser Thr Glu Ser           
                515                 520                 525               

ttg agt ccg gca gac aat cct tgc aat gtg gat gtt ttt gat gct att       1632
Leu Ser Pro Ala Asp Asn Pro Cys Asn Val Asp Val Phe Asp Ala Ile           
            530                 535                 540                   

gct gag atc cag ggc gct ctg cat ttc ttc aag gac ggt tgg tac tgg       1680
Ala Glu Ile Gln Gly Ala Leu His Phe Phe Lys Asp Gly Trp Tyr Trp           
        545                 550                 555                       

aag ttc ctg aat cat aga gga agc cca tta cag ggc ccc ttc ctt act       1728
Lys Phe Leu Asn His Arg Gly Ser Pro Leu Gln Gly Pro Phe Leu Thr           
    560                 565                 570                           

gcc cgc acg tgg cca gcc ctg cct gca acg ctg gac tcc gcc ttt gag       1776
Ala Arg Thr Trp Pro Ala Leu Pro Ala Thr Leu Asp Ser Ala Phe Glu           
575                 580                 585                 590           

gat ccg cag acc aag agg gtt ttc ttc ttc tct gga cgt caa atg tgg       1824
Asp Pro Gln Thr Lys Arg Val Phe Phe Phe Ser Gly Arg Gln Met Trp           
                595                 600                 605               

gtg tac aca ggc aag acc gtg ctg ggc ccc agg agt ctg gat aag ttg       1872
Val Tyr Thr Gly Lys Thr Val Leu Gly Pro Arg Ser Leu Asp Lys Leu           
            610                 615                 620                   

ggt cta ggc cca gag gta acc cac gtc agc ggg ctt ctc ccg cgt cgt       1920
Gly Leu Gly Pro Glu Val Thr His Val Ser Gly Leu Leu Pro Arg Arg           
        625                 630                 635                       

ctc ggg aag gct ctg ctg ttc agc aag ggg cgt gtc tgg aga ttc gac       1968
Leu Gly Lys Ala Leu Leu Phe Ser Lys Gly Arg Val Trp Arg Phe Asp           
    640                 645                 650                           

ttg aag tct cag aag gtg gat ccc cag agc gtc att cgc gtg gat aag       2016
Leu Lys Ser Gln Lys Val Asp Pro Gln Ser Val Ile Arg Val Asp Lys           
655                 660                 665                 670           

gag ttc tct ggt gtg ccc tgg aac tca cac gac atc ttc cag tac caa       2064
Glu Phe Ser Gly Val Pro Trp Asn Ser His Asp Ile Phe Gln Tyr Gln           
                675                 680                 685               

gac aaa gcc tat ttc tgc cat ggc aaa ttc ttc tgg cgt gtg agt ttc       2112
Asp Lys Ala Tyr Phe Cys His Gly Lys Phe Phe Trp Arg Val Ser Phe           
            690                 695                 700                   

caa aat gag gtg aac aag gtg gac cat gag gtg aac cag gtg gac gac       2160
Gln Asn Glu Val Asn Lys Val Asp His Glu Val Asn Gln Val Asp Asp           
        705                 710                 715                       

gtg ggc tac gtg acc tac gac ctc ctg cag tgc cct tga actagggctc        2209
Val Gly Tyr Val Thr Tyr Asp Leu Leu Gln Cys Pro                           
    720                 725                 730                           

cttctttgct tcaaccgtgc agtgcaagtc tctagagacc accaccacca ccaccacaca     2269

caaaccccat ccgagggaaa ggtgctagct ggccaggtac agactggtga tctcttctag     2329

agactgggaa ggagtggagg caggcagggc tctctctgcc caccgtcctt tcttgttgga     2389

ctgtttctaa taaacacgga tccccaacct tttccagcta ctttagtcaa tcagcttatc     2449

tgtagttgca gatgcatccg agcaagaaga caactttgta gggtggattc tgacctttta     2509

tttttgtgtg gcgtctgaga attgaatcag ctggcttttg tgacaggcac ttcaccggct     2569

aaaccacctc tcccgactcc agccctttta tttattatgt atgaggttat gttcacatgc     2629

atgtatttaa cccacagaat gcttactgtg tgtcgggcgc ggctccaacc gctgcataaa     2689

tattaaggta ttcagttgcc cctactggaa ggtattatgt aactatttct ctcttacatt     2749

ggagaacacc accgagctat ccactcatca aacatttatt gagagcatcc ctagggagcc     2809

aggctctcta ctgggcgtta gggacagaaa tgttggttct tccttcaagg attgctcaga     2869

gattctccgt gtcctgtaaa tctgctgaaa ccagacccca gactcctctc tctcccgaga     2929

gtccaactca ctcactgtgg ttgctggcag ctgcagcatg cgtatacagc atgtgtgcta     2989

gagaggtaga gggggtctgt gcgttatggt tcaggtcaga ctgtgtcctc caggtgagat     3049

gacccctcag ctggaactga tccaggaagg ataaccaagt gtcttcctgg cagtcttttt     3109

taaataaatg aataaatgaa tatttactta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3169

aaaaaaaaaa aaaaaa                                                     3185


<210>  26
<211>  730
<212>  PRT
<213>  Mus musculus

<400>  26

Met Ser Pro Trp Gln Pro Leu Leu Leu Ala Leu Leu Ala Phe Gly Cys 
1               5                   10                  15      


Ser Ser Ala Ala Pro Tyr Gln Arg Gln Pro Thr Phe Val Val Phe Pro 
            20                  25                  30          


Lys Asp Leu Lys Thr Ser Asn Leu Thr Asp Thr Gln Leu Ala Glu Ala 
        35                  40                  45              


Tyr Leu Tyr Arg Tyr Gly Tyr Thr Arg Ala Ala Gln Met Met Gly Glu 
    50                  55                  60                  


Lys Gln Ser Leu Arg Pro Ala Leu Leu Met Leu Gln Lys Gln Leu Ser 
65                  70                  75                  80  


Leu Pro Gln Thr Gly Glu Leu Asp Ser Gln Thr Leu Lys Ala Ile Arg 
                85                  90                  95      


Thr Pro Arg Cys Gly Val Pro Asp Val Gly Arg Phe Gln Thr Phe Lys 
            100                 105                 110         


Gly Leu Lys Trp Asp His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Asp Met Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Val Trp Gly Glu Val Ala Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Gly Pro Glu Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Ala Gly Val Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Ile Pro Thr Tyr Tyr Gly Asn 
    210                 215                 220                 


Ser Asn Gly Ala Pro Cys His Phe Pro Phe Thr Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Asn Asp Gly Thr Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asp Tyr Asp Lys Asp Gly Lys Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Glu His Gly Asn Gly Glu Gly Lys Pro Cys 
        275                 280                 285             


Val Phe Pro Phe Ile Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Lys Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Gln Asp Lys Leu Tyr Gly Phe Cys Pro Thr Arg Val Asp Ala Thr 
                325                 330                 335     


Val Val Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Val 
            340                 345                 350         


Phe Leu Gly Lys Gln Tyr Ser Ser Cys Thr Ser Asp Gly Arg Arg Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Thr Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Leu Tyr Ser Tyr Leu Glu Gly Phe Pro Leu Asn 
            420                 425                 430         


Lys Asp Asp Ile Asp Gly Ile Gln Tyr Leu Tyr Gly Arg Gly Ser Lys 
        435                 440                 445             


Pro Asp Pro Arg Pro Pro Ala Thr Thr Thr Thr Glu Pro Gln Pro Thr 
    450                 455                 460                 


Ala Pro Pro Thr Met Cys Pro Thr Ile Pro Pro Thr Ala Tyr Pro Thr 
465                 470                 475                 480 


Val Gly Pro Thr Val Gly Pro Thr Gly Ala Pro Ser Pro Gly Pro Thr 
                485                 490                 495     


Ser Ser Pro Ser Pro Gly Pro Thr Gly Ala Pro Ser Pro Gly Pro Thr 
            500                 505                 510         


Ala Pro Pro Thr Ala Gly Ser Ser Glu Ala Ser Thr Glu Ser Leu Ser 
        515                 520                 525             


Pro Ala Asp Asn Pro Cys Asn Val Asp Val Phe Asp Ala Ile Ala Glu 
    530                 535                 540                 


Ile Gln Gly Ala Leu His Phe Phe Lys Asp Gly Trp Tyr Trp Lys Phe 
545                 550                 555                 560 


Leu Asn His Arg Gly Ser Pro Leu Gln Gly Pro Phe Leu Thr Ala Arg 
                565                 570                 575     


Thr Trp Pro Ala Leu Pro Ala Thr Leu Asp Ser Ala Phe Glu Asp Pro 
            580                 585                 590         


Gln Thr Lys Arg Val Phe Phe Phe Ser Gly Arg Gln Met Trp Val Tyr 
        595                 600                 605             


Thr Gly Lys Thr Val Leu Gly Pro Arg Ser Leu Asp Lys Leu Gly Leu 
    610                 615                 620                 


Gly Pro Glu Val Thr His Val Ser Gly Leu Leu Pro Arg Arg Leu Gly 
625                 630                 635                 640 


Lys Ala Leu Leu Phe Ser Lys Gly Arg Val Trp Arg Phe Asp Leu Lys 
                645                 650                 655     


Ser Gln Lys Val Asp Pro Gln Ser Val Ile Arg Val Asp Lys Glu Phe 
            660                 665                 670         


Ser Gly Val Pro Trp Asn Ser His Asp Ile Phe Gln Tyr Gln Asp Lys 
        675                 680                 685             


Ala Tyr Phe Cys His Gly Lys Phe Phe Trp Arg Val Ser Phe Gln Asn 
    690                 695                 700                 


Glu Val Asn Lys Val Asp His Glu Val Asn Gln Val Asp Asp Val Gly 
705                 710                 715                 720 


Tyr Val Thr Tyr Asp Leu Leu Gln Cys Pro 
                725                 730 


<210>  27
<211>  2387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (20)..(2143)

<400>  27
agacacctct gccctcacc atg agc ctc tgg cag ccc ctg gtc ctg gtg ctc        52
                     Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu          
                     1               5                   10               

ctg gtg ctg ggc tgc tgc ttt gct gcc ccc aga cag cgc cag tcc acc        100
Leu Val Leu Gly Cys Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr           
            15                  20                  25                    

ctt gtg ctc ttc cct gga gac ctg aga acc aat ctc acc gac agg cag        148
Leu Val Leu Phe Pro Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln           
        30                  35                  40                        

ctg gca gag gaa tac ctg tac cgc tat ggt tac act cgg gtg gca gag        196
Leu Ala Glu Glu Tyr Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu           
    45                  50                  55                            

atg cgt gga gag tcg aaa tct ctg ggg cct gcg ctg ctg ctt ctc cag        244
Met Arg Gly Glu Ser Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln           
60                  65                  70                  75            

aag caa ctg tcc ctg ccc gag acc ggt gag ctg gat agc gcc acg ctg        292
Lys Gln Leu Ser Leu Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu           
                80                  85                  90                

aag gcc atg cga acc cca cgg tgc ggg gtc cca gac ctg ggc aga ttc        340
Lys Ala Met Arg Thr Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe           
            95                  100                 105                   

caa acc ttt gag ggc gac ctc aag tgg cac cac cac aac atc acc tat        388
Gln Thr Phe Glu Gly Asp Leu Lys Trp His His His Asn Ile Thr Tyr           
        110                 115                 120                       

tgg atc caa aac tac tcg gaa gac ttg ccg cgg gcg gtg att gac gac        436
Trp Ile Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp           
    125                 130                 135                           

gcc ttt gcc cgc gcc ttc gca ctg tgg agc gcg gtg acg ccg ctc acc        484
Ala Phe Ala Arg Ala Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr           
140                 145                 150                 155           

ttc act cgc gtg tac agc cgg gac gca gac atc gtc atc cag ttt ggt        532
Phe Thr Arg Val Tyr Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly           
                160                 165                 170               

gtc gcg gag cac gga gac ggg tat ccc ttc gac ggg aag gac ggg ctc        580
Val Ala Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu           
            175                 180                 185                   

ctg gca cac gcc ttt cct cct ggc ccc ggc att cag gga gac gcc cat        628
Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His           
        190                 195                 200                       

ttc gac gat gac gag ttg tgg tcc ctg ggc aag ggc gtc gtg gtt cca        676
Phe Asp Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro           
    205                 210                 215                           

act cgg ttt gga aac gca gat ggc gcg gcc tgc cac ttc ccc ttc atc        724
Thr Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile           
220                 225                 230                 235           

ttc gag ggc cgc tcc tac tct gcc tgc acc acc gac ggt cgc tcc gac        772
Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp           
                240                 245                 250               

ggc ttg ccc tgg tgc agt acc acg gcc aac tac gac acc gac gac cgg        820
Gly Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg           
            255                 260                 265                   

ttt ggc ttc tgc ccc agc gag aga ctc tac acc cag gac ggc aat gct        868
Phe Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala           
        270                 275                 280                       

gat ggg aaa ccc tgc cag ttt cca ttc atc ttc caa ggc caa tcc tac        916
Asp Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr           
    285                 290                 295                           

tcc gcc tgc acc acg gac ggt cgc tcc gac ggc tac cgc tgg tgc gcc        964
Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala           
300                 305                 310                 315           

acc acc gcc aac tac gac cgg gac aag ctc ttc ggc ttc tgc ccg acc       1012
Thr Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr           
                320                 325                 330               

cga gct gac tcg acg gtg atg ggg ggc aac tcg gcg ggg gag ctg tgc       1060
Arg Ala Asp Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys           
            335                 340                 345                   

gtc ttc ccc ttc act ttc ctg ggt aag gag tac tcg acc tgt acc agc       1108
Val Phe Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser           
        350                 355                 360                       

gag ggc cgc gga gat ggg cgc ctc tgg tgc gct acc acc tcg aac ttt       1156
Glu Gly Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe           
    365                 370                 375                           

gac agc gac aag aag tgg ggc ttc tgc ccg gac caa gga tac agt ttg       1204
Asp Ser Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu           
380                 385                 390                 395           

ttc ctc gtg gcg gcg cat gag ttc ggc cac gcg ctg ggc tta gat cat       1252
Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Asp His           
                400                 405                 410               

tcc tca gtg ccg gag gcg ctc atg tac cct atg tac cgc ttc act gag       1300
Ser Ser Val Pro Glu Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu           
            415                 420                 425                   

ggg ccc ccc ttg cat aag gac gac gtg aat ggc atc cgg cac ctc tat       1348
Gly Pro Pro Leu His Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr           
        430                 435                 440                       

ggt cct cgc cct gaa cct gag cca cgg cct cca acc acc acc aca ccg       1396
Gly Pro Arg Pro Glu Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro           
    445                 450                 455                           

cag ccc acg gct ccc ccg acg gtc tgc ccc acc gga ccc ccc act gtc       1444
Gln Pro Thr Ala Pro Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val           
460                 465                 470                 475           

cac ccc tca gag cgc ccc aca gct ggc ccc aca ggt ccc ccc tca gct       1492
His Pro Ser Glu Arg Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala           
                480                 485                 490               

ggc ccc aca ggt ccc ccc act gct ggc cct tct acg gcc act act gtg       1540
Gly Pro Thr Gly Pro Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val           
            495                 500                 505                   

cct ttg agt ccg gtg gac gat gcc tgc aac gtg aac atc ttc gac gcc       1588
Pro Leu Ser Pro Val Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala           
        510                 515                 520                       

atc gcg gag att ggg aac cag ctg tat ttg ttc aag gat ggg aag tac       1636
Ile Ala Glu Ile Gly Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr           
    525                 530                 535                           

tgg cga ttc tct gag ggc agg ggg agc cgg ccg cag ggc ccc ttc ctt       1684
Trp Arg Phe Ser Glu Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu           
540                 545                 550                 555           

atc gcc gac aag tgg ccc gcg ctg ccc cgc aag ctg gac tcg gtc ttt       1732
Ile Ala Asp Lys Trp Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe           
                560                 565                 570               

gag gag cgg ctc tcc aag aag ctt ttc ttc ttc tct ggg cgc cag gtg       1780
Glu Glu Arg Leu Ser Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val           
            575                 580                 585                   

tgg gtg tac aca ggc gcg tcg gtg ctg ggc ccg agg cgt ctg gac aag       1828
Trp Val Tyr Thr Gly Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys           
        590                 595                 600                       

ctg ggc ctg gga gcc gac gtg gcc cag gtg acc ggg gcc ctc cgg agt       1876
Leu Gly Leu Gly Ala Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser           
    605                 610                 615                           

ggc agg ggg aag atg ctg ctg ttc agc ggg cgg cgc ctc tgg agg ttc       1924
Gly Arg Gly Lys Met Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe           
620                 625                 630                 635           

gac gtg aag gcg cag atg gtg gat ccc cgg agc gcc agc gag gtg gac       1972
Asp Val Lys Ala Gln Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp           
                640                 645                 650               

cgg atg ttc ccc ggg gtg cct ttg gac acg cac gac gtc ttc cag tac       2020
Arg Met Phe Pro Gly Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr           
            655                 660                 665                   

cga gag aaa gcc tat ttc tgc cag gac cgc ttc tac tgg cgc gtg agt       2068
Arg Glu Lys Ala Tyr Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser           
        670                 675                 680                       

tcc cgg agt gag ttg aac cag gtg gac caa gtg ggc tac gtg acc tat       2116
Ser Arg Ser Glu Leu Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr           
    685                 690                 695                           

gac atc ctg cag tgc cct gag gac tag ggctcccgtc ctgctttggc             2163
Asp Ile Leu Gln Cys Pro Glu Asp                                           
700                 705                                                   

agtgccatgt aaatccccac tgggaccaac cctggggaag gagccagttt gccggataca     2223

aactggtatt ctgttctgga ggaaagggag gagtggaggt gggctgggcc ctctcttctc     2283

acctttgttt tttgttggag tgtttctaat aaacttggat tctctaacct ttaaaaaaaa     2343

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      2387


<210>  28
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp 
705         


<210>  29
<211>  4682
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (104)..(3568)

<400>  29
tgtttttacc cctccctcct ggccttggtg gcttcctcaa agtgtctgtg gtgcctgaaa       60

taccacagtt cacacttctt tcagggcctt gttcctttaa gtc atg act ctt aaa        115
                                                Met Thr Leu Lys           
                                                1                         

gct ctt ctg gtc aca gcc cta gcc ttg tgt cat ggc ttc aat ctg gac        163
Ala Leu Leu Val Thr Ala Leu Ala Leu Cys His Gly Phe Asn Leu Asp           
5                   10                  15                  20            

act gaa cat ccc atg acc ttc caa gag aat gca aaa ggc ttt gga cag        211
Thr Glu His Pro Met Thr Phe Gln Glu Asn Ala Lys Gly Phe Gly Gln           
                25                  30                  35                

agt gtg gtc cag ctt ggc gga acc agt gtg gtt gtt gca gcc ccc cag        259
Ser Val Val Gln Leu Gly Gly Thr Ser Val Val Val Ala Ala Pro Gln           
            40                  45                  50                    

gag gca aag gct gtt aac cag aca ggt gcc ctc tac cag tgt gac tac        307
Glu Ala Lys Ala Val Asn Gln Thr Gly Ala Leu Tyr Gln Cys Asp Tyr           
        55                  60                  65                        

agc aca agc cgg tgt cac ccc atc ccc ctg caa gta cct cca gag gct        355
Ser Thr Ser Arg Cys His Pro Ile Pro Leu Gln Val Pro Pro Glu Ala           
    70                  75                  80                            

gtg aat atg tcc ttg ggc ctg tcc ctg gct gtt tct act gtc ccc cag        403
Val Asn Met Ser Leu Gly Leu Ser Leu Ala Val Ser Thr Val Pro Gln           
85                  90                  95                  100           

cag ctg ctg gcc tgt ggc ccc acg gtg cac caa aac tgc aag gag aat        451
Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Asn Cys Lys Glu Asn           
                105                 110                 115               

act tat gtg aat gga ttg tgc tat ttg ttc ggc tcc aac ctg ctg agg        499
Thr Tyr Val Asn Gly Leu Cys Tyr Leu Phe Gly Ser Asn Leu Leu Arg           
            120                 125                 130                   

ccg ccc cag cag ttc cca gag gct ctc aga gaa tgt cct cag cag gag        547
Pro Pro Gln Gln Phe Pro Glu Ala Leu Arg Glu Cys Pro Gln Gln Glu           
        135                 140                 145                       

agt gac att gtc ttc ttg att gat ggc tcc ggt agc atc aac aac att        595
Ser Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Asn Asn Ile           
    150                 155                 160                           

gac ttt cag aag atg aag gag ttt gtc tca act gtg atg gag cag ttc        643
Asp Phe Gln Lys Met Lys Glu Phe Val Ser Thr Val Met Glu Gln Phe           
165                 170                 175                 180           

aaa aag tct aaa acc ttg ttc tct ttg atg cag tac tcg gac gag ttc        691
Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Asp Glu Phe           
                185                 190                 195               

cgg att cac ttc acc ttc aat gac ttc aag aga aac cct agc cca aga        739
Arg Ile His Phe Thr Phe Asn Asp Phe Lys Arg Asn Pro Ser Pro Arg           
            200                 205                 210                   

tca cat gtg agc ccc ata aag cag ctg aat ggg agg aca aaa act gcc        787
Ser His Val Ser Pro Ile Lys Gln Leu Asn Gly Arg Thr Lys Thr Ala           
        215                 220                 225                       

tca ggg atc cgg aaa gta gtg aga gaa ctg ttt cac aaa acc aat ggg        835
Ser Gly Ile Arg Lys Val Val Arg Glu Leu Phe His Lys Thr Asn Gly           
    230                 235                 240                           

gcc cgg gag aat gct gcg aag atc cta gtt gtc atc aca gat gga gaa        883
Ala Arg Glu Asn Ala Ala Lys Ile Leu Val Val Ile Thr Asp Gly Glu           
245                 250                 255                 260           

aaa ttc ggt gat ccc ttg gat tat aag gat gtc atc ccc gag gca gac        931
Lys Phe Gly Asp Pro Leu Asp Tyr Lys Asp Val Ile Pro Glu Ala Asp           
                265                 270                 275               

aga gca ggg gtc att cgc tac gta att ggg gtg gga aat gcc ttc aac        979
Arg Ala Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asn Ala Phe Asn           
            280                 285                 290                   

aaa cca cag tcc cgc aga gag ctc gac acc atc gca tct aag cca gct       1027
Lys Pro Gln Ser Arg Arg Glu Leu Asp Thr Ile Ala Ser Lys Pro Ala           
        295                 300                 305                       

ggt gaa cac gtg ttc caa gtg gac aac ttt gaa gcc ctg aat acc att       1075
Gly Glu His Val Phe Gln Val Asp Asn Phe Glu Ala Leu Asn Thr Ile           
    310                 315                 320                           

cag aac cag ctt cag gaa aag atc ttt gca att gag ggc acg cag aca       1123
Gln Asn Gln Leu Gln Glu Lys Ile Phe Ala Ile Glu Gly Thr Gln Thr           
325                 330                 335                 340           

gga agt acc agc tcc ttt gag cat gag atg tct caa gaa ggc ttc agt       1171
Gly Ser Thr Ser Ser Phe Glu His Glu Met Ser Gln Glu Gly Phe Ser           
                345                 350                 355               

gct tcc att acc tct aat ggt ccc ttg ctg ggc tct gtg ggg agc ttt       1219
Ala Ser Ile Thr Ser Asn Gly Pro Leu Leu Gly Ser Val Gly Ser Phe           
            360                 365                 370                   

gac tgg gca ggt gga gcc ttc ctg tat aca tcg aag gat aaa gtc acc       1267
Asp Trp Ala Gly Gly Ala Phe Leu Tyr Thr Ser Lys Asp Lys Val Thr           
        375                 380                 385                       

ttc atc aac aca acc aga gtg gat tca gac atg aat gat gct tac ctg       1315
Phe Ile Asn Thr Thr Arg Val Asp Ser Asp Met Asn Asp Ala Tyr Leu           
    390                 395                 400                           

ggt tat gct tct gca gtc atc ttg agg aac cgt gtc caa agc ttg gtt       1363
Gly Tyr Ala Ser Ala Val Ile Leu Arg Asn Arg Val Gln Ser Leu Val           
405                 410                 415                 420           

tta gga gca cct cgg tat cag cat att ggc ttg gtg gtg atg ttc agg       1411
Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val Val Met Phe Arg           
                425                 430                 435               

gag aat ttc ggt acc tgg gag ccc cac act agc atc aag ggc agc cag       1459
Glu Asn Phe Gly Thr Trp Glu Pro His Thr Ser Ile Lys Gly Ser Gln           
            440                 445                 450                   

att ggc tct tat ttt ggg gcc tcc ctt tgc tct gtg gac atg gac gct       1507
Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser Val Asp Met Asp Ala           
        455                 460                 465                       

gat ggc aat acc aac ttg atc ctc att ggg gcc cct cat tac tat gag       1555
Asp Gly Asn Thr Asn Leu Ile Leu Ile Gly Ala Pro His Tyr Tyr Glu           
    470                 475                 480                           

aag acc cga gga ggc cag gtg tca gtg tgt ccc ttg cct cga ggg cag       1603
Lys Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu Pro Arg Gly Gln           
485                 490                 495                 500           

agg gca cgg tgg cag tgt gaa gct ctt ctc cac ggt gat cag ggt cat       1651
Arg Ala Arg Trp Gln Cys Glu Ala Leu Leu His Gly Asp Gln Gly His           
                505                 510                 515               

ccc tgg ggt cgc ttt ggg gca gcc ctg aca gtg ctg gga gac gtg aat       1699
Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly Asp Val Asn           
            520                 525                 530                   

ggg gac aaa ctg aca gat gtg gcc att ggg gcc cca gga gag cag gag       1747
Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro Gly Glu Gln Glu           
        535                 540                 545                       

aat cag ggc gct gtc tac att ttt tat gga gca tca ata gcc agc ctc       1795
Asn Gln Gly Ala Val Tyr Ile Phe Tyr Gly Ala Ser Ile Ala Ser Leu           
    550                 555                 560                           

agt gcc tcc cac agc cag cgg atc ata ggc gcc cac ttc tcc cct ggg       1843
Ser Ala Ser His Ser Gln Arg Ile Ile Gly Ala His Phe Ser Pro Gly           
565                 570                 575                 580           

ctc cag tac ttc ggg cag tct ctg agt ggg ggt aag gat ctc aca atg       1891
Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Lys Asp Leu Thr Met           
                585                 590                 595               

gat ggc ttg atg gac ctg gct gtt ggg gcg cag ggg cat ctt ctg ctg       1939
Asp Gly Leu Met Asp Leu Ala Val Gly Ala Gln Gly His Leu Leu Leu           
            600                 605                 610                   

ctc aga gcc cag ccg gtg ctg aga ctg gag gca acc atg gaa ttc agc       1987
Leu Arg Ala Gln Pro Val Leu Arg Leu Glu Ala Thr Met Glu Phe Ser           
        615                 620                 625                       

ccc aag aaa gta gca agg agt gtg ttt gca tgt caa gaa caa gta tta       2035
Pro Lys Lys Val Ala Arg Ser Val Phe Ala Cys Gln Glu Gln Val Leu           
    630                 635                 640                           

aaa aac aag gat gct ggg gag gtc aga gtc tgc ctc cgt gtc cgc aag       2083
Lys Asn Lys Asp Ala Gly Glu Val Arg Val Cys Leu Arg Val Arg Lys           
645                 650                 655                 660           

aac acc aag gac cgt ctg cgc gaa gga gat atc cag agc act gtc act       2131
Asn Thr Lys Asp Arg Leu Arg Glu Gly Asp Ile Gln Ser Thr Val Thr           
                665                 670                 675               

tat gac ctg gct tta gac cct ggc cgc tca cgt atc cgt gcc ttc ttt       2179
Tyr Asp Leu Ala Leu Asp Pro Gly Arg Ser Arg Ile Arg Ala Phe Phe           
            680                 685                 690                   

gat gag aca aag aac aac aca cgc agg cgc acc cag gtc ttt gga ttg       2227
Asp Glu Thr Lys Asn Asn Thr Arg Arg Arg Thr Gln Val Phe Gly Leu           
        695                 700                 705                       

atg cag aaa tgt gaa aca ctg aag cta att tta ccg gac tgc gtg gac       2275
Met Gln Lys Cys Glu Thr Leu Lys Leu Ile Leu Pro Asp Cys Val Asp           
    710                 715                 720                           

gac tca gtg agc ccc atc atc ctg cgc ctc aat tat aca ctg gtt ggg       2323
Asp Ser Val Ser Pro Ile Ile Leu Arg Leu Asn Tyr Thr Leu Val Gly           
725                 730                 735                 740           

gag ccc ttg agg tcc ttt ggg aac ctc cga cca gtt ctg gct atg gat       2371
Glu Pro Leu Arg Ser Phe Gly Asn Leu Arg Pro Val Leu Ala Met Asp           
                745                 750                 755               

gct cag agg ttc ttc aca gct atg ttt ccc ttt gag aaa aat tgc ggc       2419
Ala Gln Arg Phe Phe Thr Ala Met Phe Pro Phe Glu Lys Asn Cys Gly           
            760                 765                 770                   

aat gac agc atc tgc caa gac gat ctc agc atc acc atg agt gcc atg       2467
Asn Asp Ser Ile Cys Gln Asp Asp Leu Ser Ile Thr Met Ser Ala Met           
        775                 780                 785                       

ggc ttg gac act ttg gtg gtg gga ggc ccc cag gac ttt aac atg agt       2515
Gly Leu Asp Thr Leu Val Val Gly Gly Pro Gln Asp Phe Asn Met Ser           
    790                 795                 800                           

gtg act ctg aga aat gac ggt gag gat tcc tac ggg acc cag gtt acc       2563
Val Thr Leu Arg Asn Asp Gly Glu Asp Ser Tyr Gly Thr Gln Val Thr           
805                 810                 815                 820           

gtc tac tac cca tct ggc tta tct tac cgg aag gat tca gca agc cag       2611
Val Tyr Tyr Pro Ser Gly Leu Ser Tyr Arg Lys Asp Ser Ala Ser Gln           
                825                 830                 835               

aac ccg ctc acc aag aag cct tgg ttt gta aag cct gct gag tcc agc       2659
Asn Pro Leu Thr Lys Lys Pro Trp Phe Val Lys Pro Ala Glu Ser Ser           
            840                 845                 850                   

tct tct tct gaa ggg cat ggg gct ctg aag agt acc acc tgg aac ata       2707
Ser Ser Ser Glu Gly His Gly Ala Leu Lys Ser Thr Thr Trp Asn Ile           
        855                 860                 865                       

aac cat ccc atc ttt cct gct aat tct gag gtc aca ttt aat gtc aca       2755
Asn His Pro Ile Phe Pro Ala Asn Ser Glu Val Thr Phe Asn Val Thr           
    870                 875                 880                           

ttt gat gtg gac tct cat gcc tcc ttt ggg aac aaa ctg ctc ctc aaa       2803
Phe Asp Val Asp Ser His Ala Ser Phe Gly Asn Lys Leu Leu Leu Lys           
885                 890                 895                 900           

gcc att gtg gcc agt gag aac aac atg tcc agg acc cac aaa acc aag       2851
Ala Ile Val Ala Ser Glu Asn Asn Met Ser Arg Thr His Lys Thr Lys           
                905                 910                 915               

ttt cag ttg gag ctg cct gtg aag tac gcc atc tac atg att gtc acc       2899
Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Ile Tyr Met Ile Val Thr           
            920                 925                 930                   

agt gat gag agt tct atc aga tat ctc aac ttc acg gct tca gag atg       2947
Ser Asp Glu Ser Ser Ile Arg Tyr Leu Asn Phe Thr Ala Ser Glu Met           
        935                 940                 945                       

acc agt aag gtc ata cag cat cag tac cag ttc aac aac ctg ggc cag       2995
Thr Ser Lys Val Ile Gln His Gln Tyr Gln Phe Asn Asn Leu Gly Gln           
    950                 955                 960                           

agg agc ctc cct gtc agt gta gtc ttc tgg atc cct gtt cag atc aac       3043
Arg Ser Leu Pro Val Ser Val Val Phe Trp Ile Pro Val Gln Ile Asn           
965                 970                 975                 980           

aat gtg acc gta tgg gat cat ccc cag gtc atc ttc tcc cag aac ctc       3091
Asn Val Thr Val Trp Asp His Pro Gln Val Ile Phe Ser Gln Asn Leu           
                985                 990                 995               

tca agt gcc tgt  cac act gag cag aaa  tcc ccc cct cac tcc  aat        3136
Ser Ser Ala Cys  His Thr Glu Gln Lys  Ser Pro Pro His Ser  Asn            
            1000                 1005                 1010                

ttc cgg gat cag  ctt gaa agg acc cca  gtg ctg aac tgc tct  gtt        3181
Phe Arg Asp Gln  Leu Glu Arg Thr Pro  Val Leu Asn Cys Ser  Val            
            1015                 1020                 1025                

gca gtc tgt aag  aga att cag tgt gac  ctt cca tcc ttc aac  act        3226
Ala Val Cys Lys  Arg Ile Gln Cys Asp  Leu Pro Ser Phe Asn  Thr            
            1030                 1035                 1040                

cag gaa ata ttc  aat gtc acc ctc aag  ggc aac cta tca ttt  gac        3271
Gln Glu Ile Phe  Asn Val Thr Leu Lys  Gly Asn Leu Ser Phe  Asp            
            1045                 1050                 1055                

tgg tac atc aag  act tct cat ggt cac  ctc ctg ctt gtg agc  agc        3316
Trp Tyr Ile Lys  Thr Ser His Gly His  Leu Leu Leu Val Ser  Ser            
            1060                 1065                 1070                

act gag atc ctg  ttt aat gac tct gcg  ttt gcc ctg ctt cca  ggg        3361
Thr Glu Ile Leu  Phe Asn Asp Ser Ala  Phe Ala Leu Leu Pro  Gly            
            1075                 1080                 1085                

cag gag tcg tat  gtg agg tct aag aca  gag acc aaa gtg gag  cca        3406
Gln Glu Ser Tyr  Val Arg Ser Lys Thr  Glu Thr Lys Val Glu  Pro            
            1090                 1095                 1100                

tat gaa gtt cac  aat cct gta cca ctc  att gtg ggc agc tcc  att        3451
Tyr Glu Val His  Asn Pro Val Pro Leu  Ile Val Gly Ser Ser  Ile            
            1105                 1110                 1115                

ggg ggc ctg gtg  ctc ttg gct ctc atc  act gct ggc cta tac  aag        3496
Gly Gly Leu Val  Leu Leu Ala Leu Ile  Thr Ala Gly Leu Tyr  Lys            
            1120                 1125                 1130                

ctt ggc ttt ttc  aag cgg cag tac aag  gac atg atg aat gaa  gct        3541
Leu Gly Phe Phe  Lys Arg Gln Tyr Lys  Asp Met Met Asn Glu  Ala            
            1135                 1140                 1145                

gcc ccc caa gac  gcc cca cct cag taa cggccttttc tccatgcatt            3588
Ala Pro Gln Asp  Ala Pro Pro Gln                                          
            1150                                                          

gacctcccca gcaacaagca ggtctagatg gtcagaccaa caccgaagct gatggacaca     3648

tatgttgttg ctgtgatgtc ttatacaaaa atggaatgtg tgtgtgtgtg tgtgtgtgag     3708

agagagagag agagagaaag agagagagag aaagagagag ggagagggag agagagagag     3768

agagagagag agaagaaaag aggaagcaag ctctgtgtgt ggctcacaca tttcttgcct     3828

gtgaccaatg ccttaaatgc atcctcttgg aaggaaaggc atctcttggg tttcctagtg     3888

tgttagggaa gctgctaatg ggtccttctc tgggcaaggc tgtgggaccc ttgtgggtaa     3948

gcatagctaa atgctgtgct gtcctctctg aaggaagtaa tatttccttg tttgtgtgag     4008

ctgcagactt gcaagggttt aggtgctgag aatacaagag aagttggaat agagaactgg     4068

aaagccagca gagatgttca gtgaaaaatg agacgcctcc taccatctag tcatttatta     4128

ttttaacatt aatttaaata attgaatcga ttaacccgtc aaagtacaaa aaccaaaaga     4188

tactcaagaa tggtaaaagg cagggggtgg ggaggatgca gctcacagca cagtgctcac     4248

ctggaatatg caaggccttg ggctcagcat gcgacagtga aaaccaaggc aaagaaaaaa     4308

caaaccaaac caaaaatgta agtggaaaga ctcccttcct agctgttggg ggtctctcct     4368

tagggatatt aaagggtata tgtttagaat ctattccaca aagattgtag gtacctatat     4428

acacacacac acacacacac acatatacac acactgcttt aaacaagtgg taacacattt     4488

ttttactatt atgaatgttg tctttttatt aatatgctca aataaattta tataagttat     4548

aaagtagctc agagaattac cctgtgattg taatgtattt aacatttaat gtagtctcct     4608

ttggatatat aatttccagc catttgctat tatgtacaat gctgaattaa taaattgggt     4668

atatgtaaat ttta                                                       4682


<210>  30
<211>  1154
<212>  PRT
<213>  Mus musculus

<400>  30

Met Thr Leu Lys Ala Leu Leu Val Thr Ala Leu Ala Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu His Pro Met Thr Phe Gln Glu Asn Ala Lys 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gly Gly Thr Ser Val Val Val 
        35                  40                  45              


Ala Ala Pro Gln Glu Ala Lys Ala Val Asn Gln Thr Gly Ala Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Ser Arg Cys His Pro Ile Pro Leu Gln Val 
65                  70                  75                  80  


Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Val Ser 
                85                  90                  95      


Thr Val Pro Gln Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Asn 
            100                 105                 110         


Cys Lys Glu Asn Thr Tyr Val Asn Gly Leu Cys Tyr Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Leu Arg Pro Pro Gln Gln Phe Pro Glu Ala Leu Arg Glu Cys 
    130                 135                 140                 


Pro Gln Gln Glu Ser Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Asn Asn Ile Asp Phe Gln Lys Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Phe Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Asp Glu Phe Arg Ile His Phe Thr Phe Asn Asp Phe Lys Arg Asn 
        195                 200                 205             


Pro Ser Pro Arg Ser His Val Ser Pro Ile Lys Gln Leu Asn Gly Arg 
    210                 215                 220                 


Thr Lys Thr Ala Ser Gly Ile Arg Lys Val Val Arg Glu Leu Phe His 
225                 230                 235                 240 


Lys Thr Asn Gly Ala Arg Glu Asn Ala Ala Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Asp Tyr Lys Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Ala Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asn Ala Phe Asn Lys Pro Gln Ser Arg Arg Glu Leu Asp Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Ala Gly Glu His Val Phe Gln Val Asp Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Asn Thr Ile Gln Asn Gln Leu Gln Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Thr Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ser Ile Thr Ser Asn Gly Pro Leu Leu Gly Ser 
        355                 360                 365             


Val Gly Ser Phe Asp Trp Ala Gly Gly Ala Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Asp Lys Val Thr Phe Ile Asn Thr Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ser Ala Val Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Val Met Phe Arg Glu Asn Phe Gly Thr Trp Glu Pro His Thr Ser Ile 
        435                 440                 445             


Lys Gly Ser Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Met Asp Ala Asp Gly Asn Thr Asn Leu Ile Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Lys Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Gln Arg Ala Arg Trp Gln Cys Glu Ala Leu Leu His Gly 
            500                 505                 510         


Asp Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Gln Glu Asn Gln Gly Ala Val Tyr Ile Phe Tyr Gly Ala Ser 
545                 550                 555                 560 


Ile Ala Ser Leu Ser Ala Ser His Ser Gln Arg Ile Ile Gly Ala His 
                565                 570                 575     


Phe Ser Pro Gly Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Lys 
            580                 585                 590         


Asp Leu Thr Met Asp Gly Leu Met Asp Leu Ala Val Gly Ala Gln Gly 
        595                 600                 605             


His Leu Leu Leu Leu Arg Ala Gln Pro Val Leu Arg Leu Glu Ala Thr 
    610                 615                 620                 


Met Glu Phe Ser Pro Lys Lys Val Ala Arg Ser Val Phe Ala Cys Gln 
625                 630                 635                 640 


Glu Gln Val Leu Lys Asn Lys Asp Ala Gly Glu Val Arg Val Cys Leu 
                645                 650                 655     


Arg Val Arg Lys Asn Thr Lys Asp Arg Leu Arg Glu Gly Asp Ile Gln 
            660                 665                 670         


Ser Thr Val Thr Tyr Asp Leu Ala Leu Asp Pro Gly Arg Ser Arg Ile 
        675                 680                 685             


Arg Ala Phe Phe Asp Glu Thr Lys Asn Asn Thr Arg Arg Arg Thr Gln 
    690                 695                 700                 


Val Phe Gly Leu Met Gln Lys Cys Glu Thr Leu Lys Leu Ile Leu Pro 
705                 710                 715                 720 


Asp Cys Val Asp Asp Ser Val Ser Pro Ile Ile Leu Arg Leu Asn Tyr 
                725                 730                 735     


Thr Leu Val Gly Glu Pro Leu Arg Ser Phe Gly Asn Leu Arg Pro Val 
            740                 745                 750         


Leu Ala Met Asp Ala Gln Arg Phe Phe Thr Ala Met Phe Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Asn Asp Ser Ile Cys Gln Asp Asp Leu Ser Ile Thr 
    770                 775                 780                 


Met Ser Ala Met Gly Leu Asp Thr Leu Val Val Gly Gly Pro Gln Asp 
785                 790                 795                 800 


Phe Asn Met Ser Val Thr Leu Arg Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Gln Val Thr Val Tyr Tyr Pro Ser Gly Leu Ser Tyr Arg Lys Asp 
            820                 825                 830         


Ser Ala Ser Gln Asn Pro Leu Thr Lys Lys Pro Trp Phe Val Lys Pro 
        835                 840                 845             


Ala Glu Ser Ser Ser Ser Ser Glu Gly His Gly Ala Leu Lys Ser Thr 
    850                 855                 860                 


Thr Trp Asn Ile Asn His Pro Ile Phe Pro Ala Asn Ser Glu Val Thr 
865                 870                 875                 880 


Phe Asn Val Thr Phe Asp Val Asp Ser His Ala Ser Phe Gly Asn Lys 
                885                 890                 895     


Leu Leu Leu Lys Ala Ile Val Ala Ser Glu Asn Asn Met Ser Arg Thr 
            900                 905                 910         


His Lys Thr Lys Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Ile Tyr 
        915                 920                 925             


Met Ile Val Thr Ser Asp Glu Ser Ser Ile Arg Tyr Leu Asn Phe Thr 
    930                 935                 940                 


Ala Ser Glu Met Thr Ser Lys Val Ile Gln His Gln Tyr Gln Phe Asn 
945                 950                 955                 960 


Asn Leu Gly Gln Arg Ser Leu Pro Val Ser Val Val Phe Trp Ile Pro 
                965                 970                 975     


Val Gln Ile Asn Asn Val Thr Val Trp Asp His Pro Gln Val Ile Phe 
            980                 985                 990         


Ser Gln Asn Leu Ser Ser Ala Cys  His Thr Glu Gln Lys  Ser Pro Pro 
        995                 1000                 1005             


His Ser  Asn Phe Arg Asp Gln  Leu Glu Arg Thr Pro  Val Leu Asn 
    1010                 1015                 1020             


Cys Ser  Val Ala Val Cys Lys  Arg Ile Gln Cys Asp  Leu Pro Ser 
    1025                 1030                 1035             


Phe Asn  Thr Gln Glu Ile Phe  Asn Val Thr Leu Lys  Gly Asn Leu 
    1040                 1045                 1050             


Ser Phe  Asp Trp Tyr Ile Lys  Thr Ser His Gly His  Leu Leu Leu 
    1055                 1060                 1065             


Val Ser  Ser Thr Glu Ile Leu  Phe Asn Asp Ser Ala  Phe Ala Leu 
    1070                 1075                 1080             


Leu Pro  Gly Gln Glu Ser Tyr  Val Arg Ser Lys Thr  Glu Thr Lys 
    1085                 1090                 1095             


Val Glu  Pro Tyr Glu Val His  Asn Pro Val Pro Leu  Ile Val Gly 
    1100                 1105                 1110             


Ser Ser  Ile Gly Gly Leu Val  Leu Leu Ala Leu Ile  Thr Ala Gly 
    1115                 1120                 1125             


Leu Tyr  Lys Leu Gly Phe Phe  Lys Arg Gln Tyr Lys  Asp Met Met 
    1130                 1135                 1140             


Asn Glu  Ala Ala Pro Gln Asp  Ala Pro Pro Gln 
    1145                 1150                 


<210>  31
<211>  4745
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (99)..(3560)

<400>  31
ttttctgccc ttctttgctt tggtggcttc cttgtggttc ctcagtggtg cctgcaaccc       60

ctggttcacc tccttccagg ttctggctcc ttccagcc atg gct ctc aga gtc ctt      116
                                          Met Ala Leu Arg Val Leu         
                                          1               5               

ctg tta aca gcc ttg acc tta tgt cat ggg ttc aac ttg gac act gaa        164
Leu Leu Thr Ala Leu Thr Leu Cys His Gly Phe Asn Leu Asp Thr Glu           
            10                  15                  20                    

aac gca atg acc ttc caa gag aac gca agg ggc ttc ggg cag agc gtg        212
Asn Ala Met Thr Phe Gln Glu Asn Ala Arg Gly Phe Gly Gln Ser Val           
        25                  30                  35                        

gtc cag ctt cag gga tcc agg gtg gtg gtt gga gcc ccc cag gag ata        260
Val Gln Leu Gln Gly Ser Arg Val Val Val Gly Ala Pro Gln Glu Ile           
    40                  45                  50                            

gtg gct gcc aac caa agg ggc agc ctc tac cag tgc gac tac agc aca        308
Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr Gln Cys Asp Tyr Ser Thr           
55                  60                  65                  70            

ggc tca tgc gag ccc atc cgc ctg cag gtc ccc gtg gag gcc gtg aac        356
Gly Ser Cys Glu Pro Ile Arg Leu Gln Val Pro Val Glu Ala Val Asn           
                75                  80                  85                

atg tcc ctg ggc ctg tcc ctg gca gcc acc acc agc ccc cct cag ctg        404
Met Ser Leu Gly Leu Ser Leu Ala Ala Thr Thr Ser Pro Pro Gln Leu           
            90                  95                  100                   

ctg gcc tgt ggt ccc acc gtg cac cag act tgc agt gag aac acg tat        452
Leu Ala Cys Gly Pro Thr Val His Gln Thr Cys Ser Glu Asn Thr Tyr           
        105                 110                 115                       

gtg aaa ggg ctc tgc ttc ctg ttt gga tcc aac cta cgg cag cag ccc        500
Val Lys Gly Leu Cys Phe Leu Phe Gly Ser Asn Leu Arg Gln Gln Pro           
    120                 125                 130                           

cag aag ttc cca gag gcc ctc cga ggg tgt cct caa gag gat agt gac        548
Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys Pro Gln Glu Asp Ser Asp           
135                 140                 145                 150           

att gcc ttc ttg att gat ggc tct ggt agc atc atc cca cat gac ttt        596
Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser Ile Ile Pro His Asp Phe           
                155                 160                 165               

cgg cgg atg aag gag ttt gtc tca act gtg atg gag caa tta aaa aag        644
Arg Arg Met Lys Glu Phe Val Ser Thr Val Met Glu Gln Leu Lys Lys           
            170                 175                 180                   

tcc aaa acc ttg ttc tct ttg atg cag tac tct gaa gaa ttc cgg att        692
Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr Ser Glu Glu Phe Arg Ile           
        185                 190                 195                       

cac ttt acc ttc aaa gag ttc cag aac aac cct aac cca aga tca ctg        740
His Phe Thr Phe Lys Glu Phe Gln Asn Asn Pro Asn Pro Arg Ser Leu           
    200                 205                 210                           

gtg aag cca ata acg cag ctg ctt ggg cgg aca cac acg gcc acg ggc        788
Val Lys Pro Ile Thr Gln Leu Leu Gly Arg Thr His Thr Ala Thr Gly           
215                 220                 225                 230           

atc cgc aaa gtg gta cga gag ctg ttt aac atc acc aac gga gcc cga        836
Ile Arg Lys Val Val Arg Glu Leu Phe Asn Ile Thr Asn Gly Ala Arg           
                235                 240                 245               

aag aat gcc ttt aag atc cta gtt gtc atc acg gat gga gaa aag ttt        884
Lys Asn Ala Phe Lys Ile Leu Val Val Ile Thr Asp Gly Glu Lys Phe           
            250                 255                 260                   

ggc gat ccc ttg gga tat gag gat gtc atc cct gag gca gac aga gag        932
Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile Pro Glu Ala Asp Arg Glu           
        265                 270                 275                       

gga gtc att cgc tac gtc att ggg gtg gga gat gcc ttc cgc agt gag        980
Gly Val Ile Arg Tyr Val Ile Gly Val Gly Asp Ala Phe Arg Ser Glu           
    280                 285                 290                           

aaa tcc cgc caa gag ctt aat acc atc gca tcc aag ccg cct cgt gat       1028
Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala Ser Lys Pro Pro Arg Asp           
295                 300                 305                 310           

cac gtg ttc cag gtg aat aac ttt gag gct ctg aag acc att cag aac       1076
His Val Phe Gln Val Asn Asn Phe Glu Ala Leu Lys Thr Ile Gln Asn           
                315                 320                 325               

cag ctt cgg gag aag atc ttt gcg atc gag ggt act cag aca gga agt       1124
Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu Gly Thr Gln Thr Gly Ser           
            330                 335                 340                   

agc agc tcc ttt gag cat gag atg tct cag gaa ggc ttc agc gct gcc       1172
Ser Ser Ser Phe Glu His Glu Met Ser Gln Glu Gly Phe Ser Ala Ala           
        345                 350                 355                       

atc acc tct aat ggc ccc ttg ctg agc act gtg ggg agc tat gac tgg       1220
Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr Val Gly Ser Tyr Asp Trp           
    360                 365                 370                           

gct ggt gga gtc ttt cta tat aca tca aag gag aaa agc acc ttc atc       1268
Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys Glu Lys Ser Thr Phe Ile           
375                 380                 385                 390           

aac atg acc aga gtg gat tca gac atg aat gat gct tac ttg ggt tat       1316
Asn Met Thr Arg Val Asp Ser Asp Met Asn Asp Ala Tyr Leu Gly Tyr           
                395                 400                 405               

gct gcc gcc atc atc tta cgg aac cgg gtg caa agc ctg gtt ctg ggg       1364
Ala Ala Ala Ile Ile Leu Arg Asn Arg Val Gln Ser Leu Val Leu Gly           
            410                 415                 420                   

gca cct cga tat cag cac atc ggc ctg gta gcg atg ttc agg cag aac       1412
Ala Pro Arg Tyr Gln His Ile Gly Leu Val Ala Met Phe Arg Gln Asn           
        425                 430                 435                       

act ggc atg tgg gag tcc aac gct aat gtc aag ggc acc cag atc ggc       1460
Thr Gly Met Trp Glu Ser Asn Ala Asn Val Lys Gly Thr Gln Ile Gly           
    440                 445                 450                           

gcc tac ttc ggg gcc tcc ctc tgc tcc gtg gac gtg gac agc aac ggc       1508
Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val Asp Val Asp Ser Asn Gly           
455                 460                 465                 470           

agc acc gac ctg gtc ctc atc ggg gcc ccc cat tac tac gag cag acc       1556
Ser Thr Asp Leu Val Leu Ile Gly Ala Pro His Tyr Tyr Glu Gln Thr           
                475                 480                 485               

cga ggg ggc cag gtg tcc gtg tgc ccc ttg ccc agg ggg cag agg gct       1604
Arg Gly Gly Gln Val Ser Val Cys Pro Leu Pro Arg Gly Gln Arg Ala           
            490                 495                 500                   

cgg tgg cag tgt gat gct gtt ctc tac ggg gag cag ggc caa ccc tgg       1652
Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly Glu Gln Gly Gln Pro Trp           
        505                 510                 515                       

ggc cgc ttt ggg gca gcc cta aca gtg ctg ggg gac gta aat ggg gac       1700
Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly Asp Val Asn Gly Asp           
    520                 525                 530                           

aag ctg acg gac gtg gcc att ggg gcc cca gga gag gag gac aac cgg       1748
Lys Leu Thr Asp Val Ala Ile Gly Ala Pro Gly Glu Glu Asp Asn Arg           
535                 540                 545                 550           

ggt gct gtt tac ctg ttt cac gga acc tca gga tct ggc atc agc ccc       1796
Gly Ala Val Tyr Leu Phe His Gly Thr Ser Gly Ser Gly Ile Ser Pro           
                555                 560                 565               

tcc cat agc cag cgg ata gca ggc tcc aag ctc tct ccc agg ctc cag       1844
Ser His Ser Gln Arg Ile Ala Gly Ser Lys Leu Ser Pro Arg Leu Gln           
            570                 575                 580                   

tat ttt ggt cag tca ctg agt ggg ggc cag gac ctc aca atg gat gga       1892
Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln Asp Leu Thr Met Asp Gly           
        585                 590                 595                       

ctg gta gac ctg act gta gga gcc cag ggg cac gtg ctg ctg ctc agg       1940
Leu Val Asp Leu Thr Val Gly Ala Gln Gly His Val Leu Leu Leu Arg           
    600                 605                 610                           

tcc cag cca gta ctg aga gtc aag gca atc atg gag ttc aat ccc agg       1988
Ser Gln Pro Val Leu Arg Val Lys Ala Ile Met Glu Phe Asn Pro Arg           
615                 620                 625                 630           

gaa gtg gca agg aat gta ttt gag tgt aat gat cag gtg gtg aaa ggc       2036
Glu Val Ala Arg Asn Val Phe Glu Cys Asn Asp Gln Val Val Lys Gly           
                635                 640                 645               

aag gaa gcc gga gag gtc aga gtc tgc ctc cat gtc cag aag agc aca       2084
Lys Glu Ala Gly Glu Val Arg Val Cys Leu His Val Gln Lys Ser Thr           
            650                 655                 660                   

cgg gat cgg cta aga gaa gga cag atc cag agt gtt gtg act tat gac       2132
Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln Ser Val Val Thr Tyr Asp           
        665                 670                 675                       

ctg gct ctg gac tcc ggc cgc cca cat tcc cgc gcc gtc ttc aat gag       2180
Leu Ala Leu Asp Ser Gly Arg Pro His Ser Arg Ala Val Phe Asn Glu           
    680                 685                 690                           

aca aag aac agc aca cgc aga cag aca cag gtc ttg ggg ctg acc cag       2228
Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln Val Leu Gly Leu Thr Gln           
695                 700                 705                 710           

act tgt gag acc ctg aaa cta cag ttg ccg aat tgc atc gag gac cca       2276
Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro Asn Cys Ile Glu Asp Pro           
                715                 720                 725               

gtg agc ccc att gtg ctg cgc ctg aac ttc tct ctg gtg gga acg cca       2324
Val Ser Pro Ile Val Leu Arg Leu Asn Phe Ser Leu Val Gly Thr Pro           
            730                 735                 740                   

ttg tct gct ttc ggg aac ctc cgg cca gtg ctg gcg gag gat gct cag       2372
Leu Ser Ala Phe Gly Asn Leu Arg Pro Val Leu Ala Glu Asp Ala Gln           
        745                 750                 755                       

aga ctc ttc aca gcc ttg ttt ccc ttt gag aag aat tgt ggc aat gac       2420
Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu Lys Asn Cys Gly Asn Asp           
    760                 765                 770                           

aac atc tgc cag gat gac ctc agc atc acc ttc agt ttc atg agc ctg       2468
Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr Phe Ser Phe Met Ser Leu           
775                 780                 785                 790           

gac tgc ctc gtg gtg ggt ggg ccc cgg gag ttc aac gtg aca gtg act       2516
Asp Cys Leu Val Val Gly Gly Pro Arg Glu Phe Asn Val Thr Val Thr           
                795                 800                 805               

gtg aga aat gat ggt gag gac tcc tac agg aca cag gtc acc ttc ttc       2564
Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg Thr Gln Val Thr Phe Phe           
            810                 815                 820                   

ttc ccg ctt gac ctg tcc tac cgg aag gtg tcc acg ctc cag aac cag       2612
Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val Ser Thr Leu Gln Asn Gln           
        825                 830                 835                       

cgc tca cag cga tcc tgg cgc ctg gcc tgt gag tct gcc tcc tcc acc       2660
Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys Glu Ser Ala Ser Ser Thr           
    840                 845                 850                           

gaa gtg tct ggg gcc ttg aag agc acc agc tgc agc ata aac cac ccc       2708
Glu Val Ser Gly Ala Leu Lys Ser Thr Ser Cys Ser Ile Asn His Pro           
855                 860                 865                 870           

atc ttc ccg gaa aac tca gag gtc acc ttt aat atc acg ttt gat gta       2756
Ile Phe Pro Glu Asn Ser Glu Val Thr Phe Asn Ile Thr Phe Asp Val           
                875                 880                 885               

gac tct aag gct tcc ctt gga aac aaa ctg ctc ctc aag gcc aat gtg       2804
Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu Leu Leu Lys Ala Asn Val           
            890                 895                 900                   

acc agt gag aac aac atg ccc aga acc aac aaa acc gaa ttc caa ctg       2852
Thr Ser Glu Asn Asn Met Pro Arg Thr Asn Lys Thr Glu Phe Gln Leu           
        905                 910                 915                       

gag ctg ccg gtg aaa tat gct gtc tac atg gtg gtc acc agc cat ggg       2900
Glu Leu Pro Val Lys Tyr Ala Val Tyr Met Val Val Thr Ser His Gly           
    920                 925                 930                           

gtc tcc act aaa tat ctc aac ttc acg gcc tca gag aat acc agt cgg       2948
Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala Ser Glu Asn Thr Ser Arg           
935                 940                 945                 950           

gtc atg cag cat caa tat cag gtc agc aac ctg ggg cag agg agc ctc       2996
Val Met Gln His Gln Tyr Gln Val Ser Asn Leu Gly Gln Arg Ser Leu           
                955                 960                 965               

ccc atc agc ctg gtg ttc ttg gtg ccc gtc cgg ctg aac cag act gtc       3044
Pro Ile Ser Leu Val Phe Leu Val Pro Val Arg Leu Asn Gln Thr Val           
            970                 975                 980                   

ata tgg gac cgc ccc cag gtc acc ttc tcc gag aac ctc tcg agt acg       3092
Ile Trp Asp Arg Pro Gln Val Thr Phe Ser Glu Asn Leu Ser Ser Thr           
        985                 990                 995                       

tgc cac  acc aag gag cgc ttg  ccc tct cac tcc gac  ttt ctg gct        3137
Cys His  Thr Lys Glu Arg Leu  Pro Ser His Ser Asp  Phe Leu Ala            
    1000                 1005                 1010                        

gag ctt  cgg aag gcc ccc gtg  gtg aac tgc tcc atc  gct gtc tgc        3182
Glu Leu  Arg Lys Ala Pro Val  Val Asn Cys Ser Ile  Ala Val Cys            
    1015                 1020                 1025                        

cag aga  atc cag tgt gac atc  ccg ttc ttt ggc atc  cag gaa gaa        3227
Gln Arg  Ile Gln Cys Asp Ile  Pro Phe Phe Gly Ile  Gln Glu Glu            
    1030                 1035                 1040                        

ttc aat  gct acc ctc aaa ggc  aac ctc tcg ttt gac  tgg tac atc        3272
Phe Asn  Ala Thr Leu Lys Gly  Asn Leu Ser Phe Asp  Trp Tyr Ile            
    1045                 1050                 1055                        

aag acc  tcg cat aac cac ctc  ctg atc gtg agc aca  gct gag atc        3317
Lys Thr  Ser His Asn His Leu  Leu Ile Val Ser Thr  Ala Glu Ile            
    1060                 1065                 1070                        

ttg ttt  aac gat tcc gtg ttc  acc ctg ctg ccg gga  cag ggg gcg        3362
Leu Phe  Asn Asp Ser Val Phe  Thr Leu Leu Pro Gly  Gln Gly Ala            
    1075                 1080                 1085                        

ttt gtg  agg tcc cag acg gag  acc aaa gtg gag ccg  ttc gag gtc        3407
Phe Val  Arg Ser Gln Thr Glu  Thr Lys Val Glu Pro  Phe Glu Val            
    1090                 1095                 1100                        

ccc aac  ccc ctg ccg ctc atc  gtg ggc agc tct gtc  ggg gga ctg        3452
Pro Asn  Pro Leu Pro Leu Ile  Val Gly Ser Ser Val  Gly Gly Leu            
    1105                 1110                 1115                        

ctg ctc  ctg gcc ctc atc acc  gcc gcg ctg tac aag  ctc ggc ttc        3497
Leu Leu  Leu Ala Leu Ile Thr  Ala Ala Leu Tyr Lys  Leu Gly Phe            
    1120                 1125                 1130                        

ttc aag  cgg caa tac aag gac  atg atg agt gaa ggg  ggt ccc ccg        3542
Phe Lys  Arg Gln Tyr Lys Asp  Met Met Ser Glu Gly  Gly Pro Pro            
    1135                 1140                 1145                        

ggg gcc  gaa ccc cag tag cggctccttc ccgacagagc tgcctctcgg             3590
Gly Ala  Glu Pro Gln                                                      
    1150                                                                  

tggccagcag gactctgccc agaccacacg tagcccccag gctgctggac acgtcggaca     3650

gcgaagtatc cccgacagga cgggcttggg cttccatttg tgtgtgtgca agtgtgtatg     3710

tgcgtgtgtg caagtgtctg tgtgcaagtg tgtgcacatg tgtgcgtgtg cgtgcatgtg     3770

cacttgcacg cccatgtgtg agtgtgtgca agtatgtgag tgtgtccaag tgtgtgtgcg     3830

tgtgtccatg tgtgtgcaag tgtgtgcatg tgtgcgagtg tgtgcatgtg tgtgctcagg     3890

ggcgtgtggc tcacgtgtgt gactcagatg tctctggcgt gtgggtaggt gacggcagcg     3950

tagcctctcc ggcagaaggg aactgcctgg gctcccttgt gcgtgggtga agccgctgct     4010

gggttttcct ccgggagagg ggacggtcaa tcctgtgggt gaagacagag ggaaacacag     4070

cagcttctct ccactgaaag aagtgggact tcccgtcgcc tgcgagcctg cggcctgctg     4130

gagcctgcgc agcttggatg gagactccat gagaagccgt gggtggaacc aggaacctcc     4190

tccacaccag cgctgatgcc caataaagat gcccactgag gaatgatgaa gcttcctttc     4250

tggattcatt tattatttca atgtgacttt aattttttgg atggataagc ttgtctatgg     4310

tacaaaaatc acaaggcatt caagtgtaca gtgaaaagtc tccctttcca gatattcaag     4370

tcacctcctt aaaggtagtc aagattgtgt tttgaggttt ccttcagaca gattccaggc     4430

gatgtgcaag tgtatgcacg tgtgcacaca caccacacat acacacacac aagctttttt     4490

acacaaatgg tagcatactt tatattggtc tgtatcttgc tttttttcac caatatttct     4550

cagacatcgg ttcatattaa gacataaatt actttttcat tcttttatac cgctgcatag     4610

tattccattg tgtgagtgta ccataatgta tttaaccagt cttcttttga tatactattt     4670

tcattctctt gttattgcat caatgctgag ttaataaatc aaatatatgt catttttgca     4730

tatatgtaag gataa                                                      4745


<210>  32
<211>  1153
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Gln Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser 
545                 550                 555                 560 


Gly Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys 
                565                 570                 575     


Leu Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly 
        595                 600                 605             


His Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile 
    610                 615                 620                 


Met Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn 
625                 630                 635                 640 


Asp Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu 
                645                 650                 655     


His Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln 
            660                 665                 670         


Ser Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser 
        675                 680                 685             


Arg Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln 
    690                 695                 700                 


Val Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro 
705                 710                 715                 720 


Asn Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe 
                725                 730                 735     


Ser Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val 
            740                 745                 750         


Leu Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr 
    770                 775                 780                 


Phe Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu 
785                 790                 795                 800 


Phe Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg 
                805                 810                 815     


Thr Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val 
            820                 825                 830         


Ser Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys 
        835                 840                 845             


Glu Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser 
    850                 855                 860                 


Cys Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe 
865                 870                 875                 880 


Asn Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu 
                885                 890                 895     


Leu Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn 
            900                 905                 910         


Lys Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met 
        915                 920                 925             


Val Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala 
    930                 935                 940                 


Ser Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn 
945                 950                 955                 960 


Leu Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val 
                965                 970                 975     


Arg Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser 
            980                 985                 990         


Glu Asn Leu Ser Ser Thr Cys His  Thr Lys Glu Arg Leu  Pro Ser His 
        995                 1000                 1005             


Ser Asp  Phe Leu Ala Glu Leu  Arg Lys Ala Pro Val  Val Asn Cys 
    1010                 1015                 1020             


Ser Ile  Ala Val Cys Gln Arg  Ile Gln Cys Asp Ile  Pro Phe Phe 
    1025                 1030                 1035             


Gly Ile  Gln Glu Glu Phe Asn  Ala Thr Leu Lys Gly  Asn Leu Ser 
    1040                 1045                 1050             


Phe Asp  Trp Tyr Ile Lys Thr  Ser His Asn His Leu  Leu Ile Val 
    1055                 1060                 1065             


Ser Thr  Ala Glu Ile Leu Phe  Asn Asp Ser Val Phe  Thr Leu Leu 
    1070                 1075                 1080             


Pro Gly  Gln Gly Ala Phe Val  Arg Ser Gln Thr Glu  Thr Lys Val 
    1085                 1090                 1095             


Glu Pro  Phe Glu Val Pro Asn  Pro Leu Pro Leu Ile  Val Gly Ser 
    1100                 1105                 1110             


Ser Val  Gly Gly Leu Leu Leu  Leu Ala Leu Ile Thr  Ala Ala Leu 
    1115                 1120                 1125             


Tyr Lys  Leu Gly Phe Phe Lys  Arg Gln Tyr Lys Asp  Met Met Ser 
    1130                 1135                 1140             


Glu Gly  Gly Pro Pro Gly Ala  Glu Pro Gln 
    1145                 1150             


