                         SEQUENCE LISTING

<110>  MacroGenics, Inc.
       Loo, Deryk
       Huang, Ling
 
<120>  Antibodies Reactive with B7-H3, Immunologically Active Fragments 
       Thereof and Uses Thereof

<130>  1301.0071I

<150>  US 61/311,057
<151>  2010-03-05

<150>  US 61/310,695
<151>  2010-03-04

<150>  US 61/310,692
<151>  2010-03-04

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His 
    290                 295                 300                 


Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  2
<211>  948
<212>  DNA
<213>  Homo sapiens

<400>  2
atgctgcgtc ggcggggcag ccctggcatg ggtgtgcatg tgggtgcagc cctgggagca       60

ctgtggttct gcctcacagg agccctggag gtccaggtcc ctgaagaccc agtggtggca      120

ctggtgggca ccgatgccac cctgtgctgc tccttctccc ctgagcctgg cttcagcctg      180

gcacagctca acctcatctg gcagctgaca gataccaaac agctggtgca cagctttgct      240

gagggccagg accagggcag cgcctatgcc aaccgcacgg ccctcttccc ggacctgctg      300

gcacagggca acgcatccct gaggctgcag cgcgtgcgtg tggcggacga gggcagcttc      360

acctgcttcg tgagcatccg ggatttcggc agcgctgccg tcagcctgca ggtggccgct      420

ccctactcga agcccagcat gaccctggag cccaacaagg acctgcggcc aggggacacg      480

gtgaccatca cgtgctccag ctaccggggc taccctgagg ctgaggtgtt ctggcaggat      540

gggcagggtg tgcccctgac tggcaacgtg accacgtcgc agatggccaa cgagcagggc      600

ttgtttgatg tgcacagcgt cctgcgggtg gtgctgggtg cgaatggcac ctacagctgc      660

ctggtgcgca accccgtgct gcagcaggat gcgcacggct ctgtcaccat cacagggcag      720

cctatgacat tccccccaga ggccctgtgg gtgaccgtgg ggctgtctgt ctgtctcatt      780

gcactgctgg tggccctggc tttcgtgtgc tggagaaaga tcaaacagag ctgtgaggag      840

gagaatgcag gagctgagga ccaggatggg gagggagaag gctccaagac agccctgcag      900

cctctgaaac actctgacag caaagaagat gatggacaag aaatagcc                   948


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of BRCA84D Variable Light Chain

<400>  3

Asp Ile Ala Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Light Chain

<400>  4
gacattgcga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtggat actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcaacaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacaact atccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA84D Variable Light Chain CDR1

<400>  5

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  6
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Light Chain 
       CDR1

<400>  6
aaggccagtc agaatgtgga tactaatgta gcc                                    33


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA84D Variable Light Chain CDR2

<400>  7

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Light Chain 
       CDR2

<400>  8
tcggcatcct accggtacag t                                                 21


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA84D Variable Light Chain CDR3

<400>  9

Gln Gln Tyr Asn Asn Tyr Pro Phe Thr 
1               5                   


<210>  10
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Light Chain 
       CDR3

<400>  10
cagcaatata acaactatcc attcacg                                           27


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of BRCA84D Variable Heavy Chain

<400>  11

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  12
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Heavy Chain

<400>  12
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggtcgcatac attagtagtg acagtagtgc catctactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc      240

ctgcaaatga ccagtctaag gtctgaggac acggccatgt attactgtgg aagagggagg      300

gaaaacattt actacggtag taggcttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA84D Variable Heavy Chain CDR1

<400>  13

Phe Gly Met His 
1               


<210>  14
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Heavy Chain 
       CDR1

<400>  14
tttggaatgc ac                                                           12


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA84D Variable Heavy Chain CDR2

<400>  15

Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


<210>  16
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Heavy Chain 
       CDR2

<400>  16
tacattagta gtgacagtag tgccatctac tatgcagaca cagtgaag                    48


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA84D Variable Heavy Chain CDR3

<400>  17

Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  18
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Heavy Chain 
       CDR3

<400>  18
gggagggaaa acatttacta cggtagtagg cttgactac                              39


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of BRCA69D Variable Light Chain

<400>  19

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asp Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  20
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Light Chain

<400>  20
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcacgat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattgacaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttcctccgac gttcggtgga      300

ggcaccaaac tggaaatcaa a                                                321


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA69D Variable Light Chain CDR1

<400>  21

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  22
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Light Chain 
       CDR1

<400>  22
agggcaagtc aggacattag taattattta aac                                    33


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA69D Variable Light Chain CDR2

<400>  23

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Light Chain 
       CDR2

<400>  24
tacacatcac gattacactc a                                                 21


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA69D Variable Light Chain CDR3

<400>  25

Gln Gln Gly Asn Thr Leu Pro Pro Thr 
1               5                   


<210>  26
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Light Chain 
       CDR3

<400>  26
caacagggta atacgcttcc tccgacg                                           27


<210>  27
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of BRCA69D Variable Heavy Chain

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Pro Arg Leu Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Heavy Chain

<400>  28
caggttcagc tccagcagtc tggggctgag ctggcaagac ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcagtgggt aaaacagagg      120

cctggacagg gtctggaatg gattgggact atttatcctg gagatggtga tactaggtac      180

actcagaagt tcaagggcaa ggccacattg actgcagata aatcctccag cacagcctac      240

atgcaactca gcagcttggc atctgaggac tctgcggtct attactgtgc aagaagaggg      300

attccacggc tttggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA69D Variable Heavy Chain CDR1

<400>  29

Ser Tyr Trp Met Gln 
1               5   


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Heavy Chain 
       CDR1

<400>  30
agctactgga tgcag                                                        15


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA69D Variable Heavy Chain CDR2

<400>  31

Thr Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Heavy Chain 
       CDR2

<400>  32
actatttatc ctggagatgg tgatactagg tacactcaga agttcaaggg c                51


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA69D Variable Heavy Chain CDR3

<400>  33

Arg Gly Ile Pro Arg Leu Trp Tyr Phe Asp Val 
1               5                   10      


<210>  34
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Heavy Chain 
       CDR3

<400>  34
agagggattc cacggctttg gtacttcgat gtc                                    33


<210>  35
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of PRCA157 Variable Light Chain

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Thr Lys Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Arg Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105             


<210>  36
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Light Chain

<400>  36
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

attacatgtc gagcaagtga gagtatttac agttatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat acaaaaacct taccagaggg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagatatta ctgtcaacat cattatggta ctcctccgtg gacgttcggt      300

ggaggcacca acctggaaat caaa                                             324


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRCA157 Variable Light Chain CDR1

<400>  37

Arg Ala Ser Glu Ser Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  38
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Light Chain 
       CDR1

<400>  38
cgagcaagtg agagtattta cagttattta gca                                    33


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRCA157 Variable Light Chain CDR2

<400>  39

Asn Thr Lys Thr Leu Pro Glu 
1               5           


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Light Chain 
       CDR2

<400>  40
aatacaaaaa ccttaccaga g                                                 21


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRCA157 Variable Light Chain CDR3

<400>  41

Gln His His Tyr Gly Thr Pro Pro Trp 
1               5                   


<210>  42
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Light Chain 
       CDR3

<400>  42
caacatcatt atggtactcc tccgtgg                                           27


<210>  43
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of PRCA157 Variable Heavy Chain

<400>  43

Glu Val Gln Gln Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Ser Gly Gly Ser Asn Thr Tyr Tyr Pro Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  44
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Heavy Chain

<400>  44
gaggtgcagc aggtggagtc ggggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt tcctatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attaatagtg gtggaagtaa cacctactat      180

ccagacagtt tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctttac      240

ctgcaaatgc gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacatgac      300

gggggagcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRCA157 Variable Heavy Chain CDR1

<400>  45

Ser Tyr Gly Met Ser 
1               5   


<210>  46
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Heavy Chain 
       CDR1

<400>  46
tcctatggca tgtct                                                        15


<210>  47
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRCA157 Variable Heavy Chain CDR2

<400>  47

Val Ala Thr Ile Asn Ser Gly Gly Ser Asn Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Leu Lys Gly 
            


<210>  48
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Heavy Chain 
       CDR2

<400>  48
gtcgcaacca ttaatagtgg tggaagtaac acctactatc cagacagttt gaagggg          57


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRCA157 Variable Heavy Chain CDR3

<400>  49

His Asp Gly Gly Ala Met Asp Tyr 
1               5               


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Heavy Chain 
       CDR3

<400>  50
catgacgggg gagctatgga ctac                                              24


<210>  51
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  51

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Linker Sequence

<400>  52

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


<210>  53
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Amino Acid Linker Sequence

<400>  53
ggaggcggat ccggaggcgg aggc                                              24


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DART C-Terminal Amino acid Sequence

<400>  54

Leu Gly Gly Cys 
1               


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Domain

<400>  55

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10              


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Domain

<400>  56

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
1               5                   10  


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DART C-Terminal Amino Acid Sequence

<400>  57

Val Glu Pro Lys Ser Cys 
1               5       


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding DART C-Terminal Seuquence

<400>  58
gttgagccca aatcttgt                                                     18


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DART Cysteine-Containing Sequence

<400>  59

Leu Gly Gly Cys Phe Asn Arg Gly Glu Cys 
1               5                   10  


<210>  60
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding DART C-Terminal Cysteine-Containing 
       Sequence

<400>  60
ctgggaggct gcttcaacag gggagagtgt                                        30


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DART Cysteine Containing Sequence

<400>  61

Phe Asn Arg Gly Glu Cys 
1               5       


<210>  62
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding DART Cysteine-Containing Sequence

<400>  62
ttcaacaggg gagagtgt                                                     18


<210>  63
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DART E-Coil Amino acid Sequence

<400>  63

Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            20                  25              


<210>  64
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DART K-Coil Amino Acid Sequence

<400>  64

Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            20                  25              


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  65

Gly Gly Gly Asn Ser 
1               5   


<210>  66
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  67
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  67

Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Gly Ser 
1               5                   10                  15      


Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro Phe 
            20                  25                  30          


Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln Trp 
        35                  40                  45              


Ala Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr Glu Asp 
    50                  55                  60                  


Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu 
                85                  90                  95      


Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr Asp 
            100                 105                 110         


Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr Val 
        115                 120                 125             


Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe 
    130                 135                 140                 


Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln 
145                 150                 155                 160 


Ala Asp Cys Leu Gln Lys Leu Gln Leu Pro Pro Met Val Asn Val Ile 
                165                 170                 175     


Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser 
            180                 185                 190         


Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val 
        195                 200                 205             


Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly 
    210                 215                 220                 


Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu 
225                 230                 235                 240 


Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr 
                245                 250                 255     


His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln Ser Gln Arg Thr 
            260                 265                 270         


Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe Val Ile Ile Ile 
        275                 280                 285             


Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser Ala Ala Glu Gly 
    290                 295                 300                 


Pro 
305 


<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Light Chain

<400>  68

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  69
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Light Chain

<400>  69
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Light Chain CDR1

<400>  70

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  71
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Light Chain CDR1

<400>  71
aaggccagtc agaatgtgga tactaatgta gcc                                    33


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Light Chain CDR2

<400>  72

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Light Chain CDR2

<400>  73
tcggcatcct accggtacag t                                                 21


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Light Chain CDR3

<400>  74

Gln Gln Tyr Asn Asn Tyr Pro Phe Thr 
1               5                   


<210>  75
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Light Chain CDR3

<400>  75
cagcaatata acaactatcc attcacg                                           27


<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Humanized BRCA84D-1 Variable Heavy Chain

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  81
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Heavy Chain

<400>  81
gaggtgcagc tggtcgagtc tggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agcttcggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggaatg ggtggcctac atctcctccg actcctccgc catctactac      180

gccgacaccg tgaagggcag gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgcg ggacgaggac accgccgtgt actactgcgc cagaggccgg      300

gagaatatct actacggctc ccggctggat tattggggcc agggcaccac cgtgaccgtg      360

tcctct                                                                 366


<210>  82
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Heavy Chain CDR1

<400>  82

Phe Gly Met His 
1               


<210>  83
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Heavy Chain CDR1

<400>  83
tttggaatgc ac                                                           12


<210>  84
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D Variable Heavy Chain CDR2

<400>  84

Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


<210>  85
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Heavy Chain CDR2

<400>  85
tacattagta gtgacagtag tgccatctac tatgcagaca cagtgaag                    48


<210>  86
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Heavy Chain CDR3

<400>  86

Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  87
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Heavy Chain CDR3

<400>  87
gggagggaaa acatttacta cggtagtagg cttgactac                              39


<210>  88

<400>  88
000

<210>  89
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84D-2VL

<400>  89

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  90
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-2VL

<400>  90
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaaggcgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  91
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84D-3VL

<400>  91

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  92
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-3VL

<400>  92
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgtcc       60

gtcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  93
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84D-4VL

<400>  93

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  94
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-4VL

<400>  94
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggccaggccc ctaagctgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  95
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84D-5VL

<400>  95

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  96
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-5VL

<400>  96
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggccaggccc ctaaggcgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  97
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84D-6VL

<400>  97

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Glu Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  98
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-6VL

<400>  98
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccgagtacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  99
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84D-2VH

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  100
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-2VH

<400>  100
gaggtgcagc tggtcgagtc tggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agcttcggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggaatg ggtggcctac atctcctccg actcctccgc catctactac      180

gccgacaccg tgaagggcag gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgcg ggacgaggac accgccgtgt actactgcgg cagaggccgg      300

gagaatatct actacggctc ccggctggat tattggggcc agggcaccac cgtgaccgtg      360

tcctct                                                                 366


<210>  101
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84D-3VH

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  102
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-3VH

<400>  102
gaggtgcagc tggtcgagtc tggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agcttcggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggaatg ggtggcctac atctcctccg actcctccgc catctactac      180

gccgacaccg tgaagggcag gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgcg ggacgaggac accgccatgt actactgcgg cagaggccgg      300

gagaatatct actacggctc ccggctggat tattggggcc agggcaccac cgtgaccgtg      360

tcctct                                                                 366


<210>  103
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84D-4VH

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  104
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-4VH

<400>  104
gaggtgcagc tggtcgagtc tggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agcttcggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggaatg ggtggcctac atctcctccg actcctccgc catctactac      180

gccgacaccg tgaagggcag gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgcg gagcgaggac accgccgtgt actactgcgc cagaggccgg      300

gagaatatct actacggctc ccggctggat tattggggcc agggcaccac cgtgaccgtg      360

tcctct                                                                 366


<210>  105
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chBRCA84D Light Chain

<400>  105

Asp Ile Ala Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  106
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding chBRCA84D Light Chain

<400>  106
gacattgcga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtggat actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcaacaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacaact atccattcac gttcggctcg      300

gggacaaagt tggaaataaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  107
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chBRCA84D Heavy Chain

<400>  107

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  108
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding chBRCA84D Heavy Chain

<400>  108
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggtcgcatac attagtagtg acagtagtgc catctactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc      240

ctgcaaatga ccagtctaag gtctgaggac acggccatgt attactgtgg aagagggagg      300

gaaaacattt actacggtag taggcttgac tactggggcc aaggcaccac tctcacagtc      360

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1359


<210>  109
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR VL x hBRCA84D VH-2-E Coil DART Chain

<400>  109

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    130                 135                 140                 


Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
145                 150                 155                 160 


Trp Val Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp 
                165                 170                 175     


Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
            180                 185                 190         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr 
        195                 200                 205             


Tyr Cys Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Cys Gly 
225                 230                 235                 240 


Gly Gly Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
                245                 250                 255     


Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            260                 265                 270 


<210>  110
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding TCR VL x hBRCA84D VH-2-E Coil DART Chain

<400>  110
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgccacctc aagtgtaagt tacatgcact ggtatcagca gaaaccaggg      120

aaagccccta agcgctggat ctatgacaca tccaaactgg cttctggggt cccatcaagg      180

ttcagcggca gtggatctgg gacagaattt actctcacaa tcagcagcct gcagcctgaa      240

gattttgcaa cttattactg tcagcagtgg agtagtaacc cgctcacgtt tggccagggg      300

accaagcttg agatcaaagg aggcggatcc ggcggcggag gcgaggtgca gctggtcgag      360

tctggcggag gactggtgca gcctggcggc tccctgagac tgtcttgcgc cgcctccggc      420

ttcaccttct ccagcttcgg catgcactgg gtccgccagg ctccaggcaa gggactggaa      480

tgggtggcct acatctcctc cgactcctcc gccatctact acgccgacac cgtgaagggc      540

aggttcacca tctcccggga caacgccaag aactccctgt acctgcagat gaactccctg      600

cgggacgagg acaccgccgt gtactactgc ggcagaggcc gggagaatat ctactacggc      660

tcccggctgg attattgggg ccagggcacc accgtgaccg tgtcctccgg aggatgtggc      720

ggtggagaag tggccgcact ggagaaagag gttgctgctt tggagaagga ggtcgctgca      780

cttgaaaagg aggtcgcagc cctggagaaa                                       810


<210>  111
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84DVL-2 x TCR VH - K coil Chain

<400>  111

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe 
    130                 135                 140                 


Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr 
    210                 215                 220                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys Gly Gly 
225                 230                 235                 240 


Gly Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys 
                245                 250                 255     


Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265                 


<210>  112
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84DVL-2 x TCR VH - K coil Chain

<400>  112
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaaggcgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa gggaggcgga tccggcggcg gaggccaggt tcagctggtg      360

cagtctggag ctgaggtgaa gaagcctggg gcctcagtga aggtctcctg caaggccagc      420

ggttacaagt ttaccagcta cgtgatgcac tgggtgcgac aggcccctgg acaagggctt      480

gagtggatcg gatatattaa tccttacaat gatgttacta agtacaatga gaagttcaaa      540

ggcagagtca cgattaccgc ggacaaatcc acgagcacag cctacctgca gatgaacagc      600

ctgagatccg aggacacggc cgtgcactac tgtgcgagag ggagctacta tgattacgac      660

gggtttgttt actggggcca agggactctg gtcactgtga gctccggagg atgtggcggt      720

ggaaaagtgg ccgcactgaa ggagaaagtt gctgctttga aagagaaggt cgccgcactt      780

aaggaaaagg tcgcagccct gaaagag                                          807


<210>  113
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D VL x hBRCA84D VH-2-E Coil DART Chain

<400>  113

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Phe Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile 
                165                 170                 175     


Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly 
    210                 215                 220                 


Ser Arg Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Cys Gly Gly Gly Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu 
            260                 265                 270         


Glu Lys 
        


<210>  114
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding NKG2D VL x hBRCA84D VH-2-E Coil DART 
       Chain

<400>  114
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc aatcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg ttaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgacc tactgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagccttcc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccagtg      300

ttcggcggag ggaccaagct gaccgtccta ggaggcggat ccggcggcgg aggcgaggtg      360

cagctggtcg agtctggcgg aggactggtg cagcctggcg gctccctgag actgtcttgc      420

gccgcctccg gcttcacctt ctccagcttc ggcatgcact gggtccgcca ggctccaggc      480

aagggactgg aatgggtggc ctacatctcc tccgactcct ccgccatcta ctacgccgac      540

accgtgaagg gcaggttcac catctcccgg gacaacgcca agaactccct gtacctgcag      600

atgaactccc tgcgggacga ggacaccgcc gtgtactact gcggcagagg ccgggagaat      660

atctactacg gctcccggct ggattattgg ggccagggca ccaccgtgac cgtgtcctcc      720

ggaggatgtg gcggtggaga agtggccgca ctggagaaag aggttgctgc tttggagaag      780

gaggtcgctg cacttgaaaa ggaggtcgca gccctggaga aa                         822


<210>  115
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hBRCA84DVL-2 x NKG2D VH - K coil Chain

<400>  115

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
        115                 120                 125             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    130                 135                 140                 


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
145                 150                 155                 160 


Glu Trp Val Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
                165                 170                 175     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            180                 185                 190         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Lys Asp Arg Gly Leu Gly Asp Gly Thr Tyr Phe Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Cys Gly 
225                 230                 235                 240 


Gly Gly Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
                245                 250                 255     


Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265                 270 


<210>  116
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84DVL-2 x NKG2D VH - K coil Chain

<400>  116
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaaggcgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa gggaggcgga tccggcggcg gaggccaggt acagctggtg      360

gagtctgggg gaggcctggt caagcctgga gggtccctga gactctcctg tgcagcgtct      420

ggattcacct tcagtagcta tggcatgcac tgggtccgcc aggctccagg caaggggctg      480

gagtgggtgg catttatacg gtatgatgga agtaataaat actatgcaga ctccgtgaag      540

ggccgattca ccatctccag agacaattcc aagaacacgc tgtatctgca aatgaacagc      600

ctgagagctg aggacacggc tgtgtattac tgtgcgaaag atcgaggttt gggggatgga      660

acctactttg actactgggg ccaagggacc acggtcaccg tctcctccgg aggatgtggc      720

ggtggaaaag tggccgcact gaaggagaaa gttgctgctt tgaaagagaa ggtcgccgca      780

cttaaggaaa aggtcgcagc cctgaaagag                                       810


