SEQUENCE LISTING

<110>  ALEXION PHARMACEUTICALS, INC.
 
<120>  Methods and Compositions for Treating Degos' Disease

<130>  ALXN-153-WO1

<140>
<141>

<150> 61/309,393
<151> 2010-03-01

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1676
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 




Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             



Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         



Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Ile Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     



Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             



Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             



Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             



His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             



Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210>  2
<211>  1658
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg Val Gly 
1               5                   10                  15      


Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu Ala Phe 
            20                  25                  30          


Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe Ser Tyr 
        35                  40                  45              


Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln Asn Ser 
    50                  55                  60                  


Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln Asn Pro 
65                  70                  75                  80  


Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser Lys Ser 
                85                  90                  95      


Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile His Thr 
            100                 105                 110         


Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg Val Tyr 
        115                 120                 125             


Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val Leu Thr 
    130                 135                 140                 


Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu Ile Asp 
145                 150                 155                 160 


His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser Asn Pro 
                165                 170                 175     


Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp Phe Ser 
            180                 185                 190         


Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu Pro His 
        195                 200                 205             


Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr Lys Asn 
    210                 215                 220                 


Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr Asn Lys 
225                 230                 235                 240 


Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg Glu Asp 
                245                 250                 255     


Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln Asn Thr 
            260                 265                 270         


Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu Thr Ala 
        275                 280                 285             


Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe Ser Glu 
305                 310                 315                 320 


Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr Lys Leu 
                325                 330                 335     


Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro Tyr Pro 
            340                 345                 350         


Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly Gly Val 
        355                 360                 365             


Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu Thr Ser 
    370                 375                 380                 


Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly Val Ala 
385                 390                 395                 400 


Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu Phe Asn 
                405                 410                 415     


Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala Arg Glu 
            420                 425                 430         


Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr Leu Tyr 
        435                 440                 445             


Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu His Leu 
    450                 455                 460                 


Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile Thr His 
465                 470                 475                 480 


Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe Gly Thr 
                485                 490                 495     


Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile Pro Val 
            500                 505                 510         


Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr Ile Val 
        515                 520                 525             


Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp Leu Asn 
    530                 535                 540                 


Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser Pro Asp 
545                 550                 555                 560 


Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met Ala Thr 
                565                 570                 575     


Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala Val Tyr 
            580                 585                 590         


Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe Gln Phe 
        595                 600                 605             


Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu Asn Asn 
    610                 615                 620                 


Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn Ala Asn 
625                 630                 635                 640 


Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile Leu Arg 
                645                 650                 655     


Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr 
            660                 665                 670         


Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn 
        675                 680                 685             


Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro 
    690                 695                 700                 


Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu 
705                 710                 715                 720 


Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu His Met 
                725                 730                 735     


Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr Phe Pro 
            740                 745                 750         


Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys Gln Leu 
        755                 760                 765             


Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln Gly Ile 
    770                 775                 780                 


Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys Ala Lys 
785                 790                 795                 800 


Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser Val Val 
                805                 810                 815     


Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr Arg Thr 
            820                 825                 830         


Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly Ile Cys 
        835                 840                 845             


Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser Ser Lys 
    850                 855                 860                 



Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val Thr Phe 
865                 870                 875                 880 


Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe Ser Leu 
                885                 890                 895     


Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg Val Val 
            900                 905                 910         


Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu Asp Pro 
        915                 920                 925             


Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro Tyr Arg 
    930                 935                 940                 


Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile Leu Ser 
945                 950                 955                 960 


Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu Ser Gln 
                965                 970                 975     


Glu Gly Ile Asn Ile Leu Thr His Leu Pro Lys Gly Ser Ala Glu Ala 
            980                 985                 990         


Glu Leu Met Ser Val Val Pro Val  Phe Tyr Val Phe His  Tyr Leu Glu 
        995                 1000                 1005             


Thr Gly  Asn His Trp Asn Ile  Phe His Ser Asp Pro  Leu Ile Glu 
    1010                 1015                 1020             


Lys Gln  Lys Leu Lys Lys Lys  Leu Lys Glu Gly Met  Leu Ser Ile 
    1025                 1030                 1035             


Met Ser  Tyr Arg Asn Ala Asp  Tyr Ser Tyr Ser Val  Trp Lys Gly 
    1040                 1045                 1050             


Gly Ser  Ala Ser Thr Trp Leu  Thr Ala Phe Ala Leu  Arg Val Leu 
    1055                 1060                 1065             


Gly Gln  Val Asn Lys Tyr Val  Glu Gln Asn Gln Asn  Ser Ile Cys 
    1070                 1075                 1080             



Asn Ser  Leu Leu Trp Leu Val  Glu Asn Tyr Gln Leu  Asp Asn Gly 
    1085                 1090                 1095             


Ser Phe  Lys Glu Asn Ser Gln  Tyr Gln Pro Ile Lys  Leu Gln Gly 
    1100                 1105                 1110             


Thr Leu  Pro Val Glu Ala Arg  Glu Asn Ser Leu Tyr  Leu Thr Ala 
    1115                 1120                 1125             


Phe Thr  Val Ile Gly Ile Arg  Lys Ala Phe Asp Ile  Cys Pro Leu 
    1130                 1135                 1140             


Val Lys  Ile Asp Thr Ala Leu  Ile Lys Ala Asp Asn  Phe Leu Leu 
    1145                 1150                 1155             


Glu Asn  Thr Leu Pro Ala Gln  Ser Thr Phe Thr Leu  Ala Ile Ser 
    1160                 1165                 1170             


Ala Tyr  Ala Leu Ser Leu Gly  Asp Lys Thr His Pro  Gln Phe Arg 
    1175                 1180                 1185             


Ser Ile  Val Ser Ala Leu Lys  Arg Glu Ala Leu Val  Lys Gly Asn 
    1190                 1195                 1200             


Pro Pro  Ile Tyr Arg Phe Trp  Lys Asp Asn Leu Gln  His Lys Asp 
    1205                 1210                 1215             


Ser Ser  Val Pro Asn Thr Gly  Thr Ala Arg Met Val  Glu Thr Thr 
    1220                 1225                 1230             


Ala Tyr  Ala Leu Leu Thr Ser  Leu Asn Leu Lys Asp  Ile Asn Tyr 
    1235                 1240                 1245             


Val Asn  Pro Val Ile Lys Trp  Leu Ser Glu Glu Gln  Arg Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Phe Tyr Ser Thr Gln  Asp Thr Ile Asn Ala  Ile Glu Gly 
    1265                 1270                 1275             


Leu Thr  Glu Tyr Ser Leu Leu  Val Lys Gln Leu Arg  Leu Ser Met 
    1280                 1285                 1290             



Asp Ile  Asp Val Ser Tyr Lys  His Lys Gly Ala Leu  His Asn Tyr 
    1295                 1300                 1305             


Lys Met  Thr Asp Lys Asn Phe  Leu Gly Arg Pro Val  Glu Val Leu 
    1310                 1315                 1320             


Leu Asn  Asp Asp Leu Ile Val  Ser Thr Gly Phe Gly  Ser Gly Leu 
    1325                 1330                 1335             


Ala Thr  Val His Val Thr Thr  Val Val His Lys Thr  Ser Thr Ser 
    1340                 1345                 1350             


Glu Glu  Val Cys Ser Phe Tyr  Leu Lys Ile Asp Thr  Gln Asp Ile 
    1355                 1360                 1365             


Glu Ala  Ser His Tyr Arg Gly  Tyr Gly Asn Ser Asp  Tyr Lys Arg 
    1370                 1375                 1380             


Ile Val  Ala Cys Ala Ser Tyr  Lys Pro Ser Arg Glu  Glu Ser Ser 
    1385                 1390                 1395             


Ser Gly  Ser Ser His Ala Val  Met Asp Ile Ser Leu  Pro Thr Gly 
    1400                 1405                 1410             


Ile Ser  Ala Asn Glu Glu Asp  Leu Lys Ala Leu Val  Glu Gly Val 
    1415                 1420                 1425             


Asp Gln  Leu Phe Thr Asp Tyr  Gln Ile Lys Asp Gly  His Val Ile 
    1430                 1435                 1440             


Leu Gln  Leu Asn Ser Ile Pro  Ser Ser Asp Phe Leu  Cys Val Arg 
    1445                 1450                 1455             


Phe Arg  Ile Phe Glu Leu Phe  Glu Val Gly Phe Leu  Ser Pro Ala 
    1460                 1465                 1470             


Thr Phe  Thr Val Tyr Glu Tyr  His Arg Pro Asp Lys  Gln Cys Thr 
    1475                 1480                 1485             


Met Phe  Tyr Ser Thr Ser Asn  Ile Lys Ile Gln Lys  Val Cys Glu 
    1490                 1495                 1500             



Gly Ala  Ala Cys Lys Cys Val  Glu Ala Asp Cys Gly  Gln Met Gln 
    1505                 1510                 1515             


Glu Glu  Leu Asp Leu Thr Ile  Ser Ala Glu Thr Arg  Lys Gln Thr 
    1520                 1525                 1530             


Ala Cys  Lys Pro Glu Ile Ala  Tyr Ala Tyr Lys Val  Ser Ile Thr 
    1535                 1540                 1545             


Ser Ile  Thr Val Glu Asn Val  Phe Val Lys Tyr Lys  Ala Thr Leu 
    1550                 1555                 1560             


Leu Asp  Ile Tyr Lys Thr Gly  Glu Ala Val Ala Glu  Lys Asp Ser 
    1565                 1570                 1575             


Glu Ile  Thr Phe Ile Lys Lys  Val Thr Cys Thr Asn  Ala Glu Leu 
    1580                 1585                 1590             


Val Lys  Gly Arg Gln Tyr Leu  Ile Met Gly Lys Glu  Ala Leu Gln 
    1595                 1600                 1605             


Ile Lys  Tyr Asn Phe Ser Phe  Arg Tyr Ile Tyr Pro  Leu Asp Ser 
    1610                 1615                 1620             


Leu Thr  Trp Ile Glu Tyr Trp  Pro Arg Asp Thr Thr  Cys Ser Ser 
    1625                 1630                 1635             


Cys Gln  Ala Phe Leu Ala Asn  Leu Asp Glu Phe Ala  Glu Asp Ile 
    1640                 1645                 1650             


Phe Leu  Asn Gly Cys 
    1655             


<210>  3
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu His Met Lys Thr Leu 
65                  70                  75                  80  


Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr Phe Pro Glu Ser Trp 
                85                  90                  95      


Leu Trp Glu Val His Leu Val Pro Arg Arg Lys Gln Leu Gln Phe Ala 
            100                 105                 110         


Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln Gly Ile Gly Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys Ala Lys Val Phe Lys 
    130                 135                 140                 


Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser Val Val Arg Gly Glu 
145                 150                 155                 160 


Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr Arg Thr Ser Gly Met 
                165                 170                 175     


Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly Ile Cys Thr Ser Glu 
            180                 185                 190         


Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser Ser Lys Cys Val Arg 
        195                 200                 205             


Gln Lys Val Glu Gly Ser Ser Ser His Leu Val Thr Phe Thr Val Leu 
    210                 215                 220                 


Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe Ser Leu Glu Thr Trp 
225                 230                 235                 240 


Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg Val Val Pro Glu Gly 
                245                 250                 255     


Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu Asp Pro Arg Gly Ile 
            260                 265                 270         


Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro Tyr Arg Ile Pro Leu 
        275                 280                 285             


Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile Leu Ser Val Lys Gly 
    290                 295                 300                 


Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu Ser Gln Glu Gly Ile 
305                 310                 315                 320 


Asn Ile Leu Thr His Leu Pro Lys Gly Ser Ala Glu Ala Glu Leu Met 
                325                 330                 335     


Ser Val Val Pro Val Phe Tyr Val Phe His Tyr Leu Glu Thr Gly Asn 
            340                 345                 350         


His Trp Asn Ile Phe His Ser Asp Pro Leu Ile Glu Lys Gln Lys Leu 
        355                 360                 365             


Lys Lys Lys Leu Lys Glu Gly Met Leu Ser Ile Met Ser Tyr Arg Asn 
    370                 375                 380                 


Ala Asp Tyr Ser Tyr Ser Val Trp Lys Gly Gly Ser Ala Ser Thr Trp 
385                 390                 395                 400 


Leu Thr Ala Phe Ala Leu Arg Val Leu Gly Gln Val Asn Lys Tyr Val 
                405                 410                 415     


Glu Gln Asn Gln Asn Ser Ile Cys Asn Ser Leu Leu Trp Leu Val Glu 
            420                 425                 430         


Asn Tyr Gln Leu Asp Asn Gly Ser Phe Lys Glu Asn Ser Gln Tyr Gln 
        435                 440                 445             


Pro Ile Lys Leu Gln Gly Thr Leu Pro Val Glu Ala Arg Glu Asn Ser 
    450                 455                 460                 


Leu Tyr Leu Thr Ala Phe Thr Val Ile Gly Ile Arg Lys Ala Phe Asp 
465                 470                 475                 480 


Ile Cys Pro Leu Val Lys Ile Asp Thr Ala Leu Ile Lys Ala Asp Asn 
                485                 490                 495     


Phe Leu Leu Glu Asn Thr Leu Pro Ala Gln Ser Thr Phe Thr Leu Ala 
            500                 505                 510         


Ile Ser Ala Tyr Ala Leu Ser Leu Gly Asp Lys Thr His Pro Gln Phe 
        515                 520                 525             


Arg Ser Ile Val Ser Ala Leu Lys Arg Glu Ala Leu Val Lys Gly Asn 
    530                 535                 540                 


Pro Pro Ile Tyr Arg Phe Trp Lys Asp Asn Leu Gln His Lys Asp Ser 
545                 550                 555                 560 


Ser Val Pro Asn Thr Gly Thr Ala Arg Met Val Glu Thr Thr Ala Tyr 
                565                 570                 575     


Ala Leu Leu Thr Ser Leu Asn Leu Lys Asp Ile Asn Tyr Val Asn Pro 
            580                 585                 590         


Val Ile Lys Trp Leu Ser Glu Glu Gln Arg Tyr Gly Gly Gly Phe Tyr 
        595                 600                 605             


Ser Thr Gln Asp Thr Ile Asn Ala Ile Glu Gly Leu Thr Glu Tyr Ser 
    610                 615                 620                 


Leu Leu Val Lys Gln Leu Arg Leu Ser Met Asp Ile Asp Val Ser Tyr 
625                 630                 635                 640 


Lys His Lys Gly Ala Leu His Asn Tyr Lys Met Thr Asp Lys Asn Phe 
                645                 650                 655     


Leu Gly Arg Pro Val Glu Val Leu Leu Asn Asp Asp Leu Ile Val Ser 
            660                 665                 670         


Thr Gly Phe Gly Ser Gly Leu Ala Thr Val His Val Thr Thr Val Val 
        675                 680                 685             


His Lys Thr Ser Thr Ser Glu Glu Val Cys Ser Phe Tyr Leu Lys Ile 
    690                 695                 700                 


Asp Thr Gln Asp Ile Glu Ala Ser His Tyr Arg Gly Tyr Gly Asn Ser 
705                 710                 715                 720 


Asp Tyr Lys Arg Ile Val Ala Cys Ala Ser Tyr Lys Pro Ser Arg Glu 
                725                 730                 735     


Glu Ser Ser Ser Gly Ser Ser His Ala Val Met Asp Ile Ser Leu Pro 
            740                 745                 750         


Thr Gly Ile Ser Ala Asn Glu Glu Asp Leu Lys Ala Leu Val Glu Gly 
        755                 760                 765             


Val Asp Gln Leu Phe Thr Asp Tyr Gln Ile Lys Asp Gly His Val Ile 
    770                 775                 780                 


Leu Gln Leu Asn Ser Ile Pro Ser Ser Asp Phe Leu Cys Val Arg Phe 
785                 790                 795                 800 


Arg Ile Phe Glu Leu Phe Glu Val Gly Phe Leu Ser Pro Ala Thr Phe 
                805                 810                 815     


Thr Val Tyr Glu Tyr His Arg Pro Asp Lys Gln Cys Thr Met Phe Tyr 
            820                 825                 830         


Ser Thr Ser Asn Ile Lys Ile Gln Lys Val Cys Glu Gly Ala Ala Cys 
        835                 840                 845             


Lys Cys Val Glu Ala Asp Cys Gly Gln Met Gln Glu Glu Leu Asp Leu 
    850                 855                 860                 


Thr Ile Ser Ala Glu Thr Arg Lys Gln Thr Ala Cys Lys Pro Glu Ile 
865                 870                 875                 880 



Ala Tyr Ala Tyr Lys Val Ser Ile Thr Ser Ile Thr Val Glu Asn Val 
                885                 890                 895     


Phe Val Lys Tyr Lys Ala Thr Leu Leu Asp Ile Tyr Lys Thr Gly Glu 
            900                 905                 910         


Ala Val Ala Glu Lys Asp Ser Glu Ile Thr Phe Ile Lys Lys Val Thr 
        915                 920                 925             


Cys Thr Asn Ala Glu Leu Val Lys Gly Arg Gln Tyr Leu Ile Met Gly 
    930                 935                 940                 


Lys Glu Ala Leu Gln Ile Lys Tyr Asn Phe Ser Phe Arg Tyr Ile Tyr 
945                 950                 955                 960 


Pro Leu Asp Ser Leu Thr Trp Ile Glu Tyr Trp Pro Arg Asp Thr Thr 
                965                 970                 975     


Cys Ser Ser Cys Gln Ala Phe Leu Ala Asn Leu Asp Glu Phe Ala Glu 
            980                 985                 990         


Asp Ile Phe Leu Asn Gly Cys 
        995                 


<210>  4
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg Val Gly 
1               5                   10                  15      


Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu Ala Phe 
            20                  25                  30          


Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe Ser Tyr 
        35                  40                  45              


Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln Asn Ser 
    50                  55                  60                  


Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln Asn Pro 
65                  70                  75                  80  


Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser Lys Ser 
                85                  90                  95      


Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile His Thr 
            100                 105                 110         


Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg Val Tyr 
        115                 120                 125             


Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val Leu Thr 
    130                 135                 140                 


Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu Ile Asp 
145                 150                 155                 160 


His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser Asn Pro 
                165                 170                 175     


Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp Phe Ser 
            180                 185                 190         


Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu Pro His 
        195                 200                 205             


Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr Lys Asn 
    210                 215                 220                 


Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr Asn Lys 
225                 230                 235                 240 


Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg Glu Asp 
                245                 250                 255     


Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln Asn Thr 
            260                 265                 270         


Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu Thr Ala 
        275                 280                 285             


Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe Ser Glu 
305                 310                 315                 320 


Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr Lys Leu 
                325                 330                 335     


Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro Tyr Pro 
            340                 345                 350         


Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly Gly Val 
        355                 360                 365             


Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu Thr Ser 
    370                 375                 380                 


Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly Val Ala 
385                 390                 395                 400 


Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu Phe Asn 
                405                 410                 415     


Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala Arg Glu 
            420                 425                 430         


Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr Leu Tyr 
        435                 440                 445             


Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu His Leu 
    450                 455                 460                 


Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile Thr His 
465                 470                 475                 480 


Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe Gly Thr 
                485                 490                 495     


Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile Pro Val 
            500                 505                 510         


Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr Ile Val 
        515                 520                 525             


Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp Leu Asn 
    530                 535                 540                 


Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser Pro Asp 
545                 550                 555                 560 


Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met Ala Thr 
                565                 570                 575     


Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala Val Tyr 
            580                 585                 590         


Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe Gln Phe 
        595                 600                 605             


Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu Asn Asn 
    610                 615                 620                 


Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn Ala Asn 
625                 630                 635                 640 


Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile Leu 
                645                 650                 655 


<210>  5
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Ile Asp His Gln Gly Thr Lys Ser Ser Lys Cys Val Arg Gln Lys 
1               5                   10                  15      


Val Glu Gly Ser Ser 
            20      


<210>  6
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Ser Ser Lys Cys 
1               5   


<210>  7
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  7

Asn Phe Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr 
1               5                   10                  15      


Leu Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val 
            20                  25                  30          


Thr Leu Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu 
        35                  40                  45              


Phe Pro Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys 
    50                  55                  60                  


Arg Ile Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala 
65                  70                  75                  80  


Val Leu Ser Gln Glu Gly Ile Asn Ile Leu Thr His Leu Pro Lys Gly 
                85                  90                  95      


Ser Ala Glu Ala Glu Leu Met Ser Val Val Pro Val Phe Tyr Val Phe 
            100                 105                 110         


His Tyr Leu Glu Thr Gly Asn His Trp Asn Ile Phe His Ser Asp 
        115                 120                 125         


<210>  8
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser Ser Lys Cys 
1               5                   10                  15      


Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val Thr Phe Thr 
            20                  25                  30          


Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe Ser Leu Glu 
        35                  40                  45              


Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg Val Val Pro 
    50                  55                  60                  


Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu Asp Pro Arg 
65                  70                  75                  80  


Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro Tyr Arg Ile 
                85                  90                  95      


Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile Leu Ser Val 
            100                 105                 110         


Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu Ser Gln Glu 
        115                 120                 125             


Gly Ile Asn Ile Leu Thr His Leu Pro Lys Gly Ser Ala Glu Ala Glu 
    130                 135                 140                 


Leu Met Ser Val Val Pro Val Phe Tyr Val Phe His Tyr Leu Glu Thr 
145                 150                 155                 160 


Gly Asn His Trp Asn Ile Phe His Ser Asp Pro Leu Ile Glu Lys Gln 
                165                 170                 175     


Lys Leu Lys Lys Lys Leu Lys Glu Gly Met Leu Ser Ile Met Ser Tyr 
            180                 185                 190         


Arg Asn Ala Asp Tyr Ser Tyr Ser 
        195                 200 


<210>  9
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser His Lys Asp Met Gln Leu Gly Arg Leu His Met Lys Thr Leu Leu 
1               5                   10                  15      


Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr Phe Pro Glu Ser 
            20                  25                  30  


<210>  10
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser His Lys Asp Met Gln Leu Gly Arg Leu His Met Lys Thr Leu Leu 
1               5                   10                  15      


Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr Phe Pro Glu Ser Trp Leu 
            20                  25                  30          


Trp Glu Val His Leu Val Pro Arg Arg Lys Gln Leu Gln Phe Ala Leu 
        35                  40                  45              


Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln Gly Ile Gly Ile Ser Asn 
    50                  55                  60                  


Thr Gly Ile Cys Val Ala Asp Thr Val Lys Ala Lys Val Phe Lys Asp 
65                  70                  75                  80  


Val Phe Leu Glu Met Asn Ile Pro Tyr Ser Val Val Arg Gly Glu Gln 
                85                  90                  95      


Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr Arg Thr Ser Gly Met Gln 
            100                 105                 110         


Phe Cys Val Lys Met Ser Ala Val Glu Gly Ile Cys Thr Ser Glu Ser 
        115                 120                 125             


Pro Val Ile Asp His Gln Gly Thr Lys Ser Ser Lys Cys Val Arg Gln 
    130                 135                 140                 


Lys Val Glu Gly Ser Ser Ser His Leu Val Thr Phe Thr Val Leu Pro 
145                 150                 155                 160 


Leu Glu Ile Gly Leu His Asn Ile Asn Phe Ser Leu Glu Thr Trp Phe 
                165                 170                 175     


Gly Lys Glu Ile Leu Val Lys Thr Leu Arg Val Val Pro Glu Gly Val 
            180                 185                 190         


Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu Asp Pro Arg Gly Ile Tyr 
        195                 200                 205             


Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro Tyr Arg Ile Pro Leu Asp 
    210                 215                 220                 


Leu Val Pro Lys Thr Glu Ile Lys Arg Ile Leu Ser Val Lys Gly Leu 
225                 230                 235                 240 


Leu Val Gly Glu Ile Leu Ser Ala Val Leu Ser Gln Glu Gly Ile Asn 
                245                 250                 255     


Ile Leu Thr His Leu Pro Lys Gly Ser Ala Glu Ala Glu Leu Met Ser 
            260                 265                 270         


Val Val Pro Val Phe Tyr Val Phe His Tyr Leu Glu Thr Gly Asn His 
        275                 280                 285             


Trp Asn Ile Phe His Ser Asp Pro Leu Ile Glu Lys Gln Lys Leu Lys 
    290                 295                 300                 


Lys Lys Leu Lys Glu Gly Met Leu Ser Ile Met Ser Tyr Arg Asn Ala 
305                 310                 315                 320 


Asp Tyr Ser Tyr Ser 
                325 


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp His Gln Gly Thr Lys Ser Ser Lys Cys Val Arg Gln Lys Val Glu 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser His Lys Asp Met Gln Leu Gly Arg 
65                  70                  


<210>  13
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


Arg Ala Ala Arg 
            20  


<210>  14
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  14

Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu 
1               5                   10                  15      


Gln Arg 
        


<210>  15
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Asn Asn Asp Glu Thr Cys Glu Gln Arg 
1               5                   10  


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Val Asn Asn Asp Glu Thr 
1               5       


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Ala Arg Ile Ser Leu Gly Pro Arg 
1               5                   


<210>  18
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


Arg Ala Ala 
            


<210>  19
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


Arg Ala 
        


<210>  20
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


Arg 
    


<210>  21
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  22

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu 
1               5                   10                  15  


<210>  23
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln Arg 
1               5                   10                  15      


Ala Ala Arg 
            


<210>  24
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  24

Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala 
1               5                   10                  15      


Ala Arg 
        


<210>  25
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln Arg 
1               5                   10                  15      


Ala Ala Arg 
            


<210>  26
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser 
1               5                   10                  15      


Tyr Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg 
            20                  25                  30          


Lys Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile 
        35                  40                  45              


Gln Gly Ile Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val 
    50                  55                  60                  


Lys Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr 
65                  70                  75                  80  


Ser Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn 
                85                  90                  95      


Tyr Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu 
            100                 105                 110         


Gly Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys 
        115                 120                 125             


Ser Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu 
    130                 135                 140                 


Val Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn 
145                 150                 155                 160 


Phe Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu 
                165                 170                 175     


Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr 
            180                 185                 190         


Leu Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe 
        195                 200                 205             


Pro Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg 
    210                 215                 220                 


Ile Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val 
225                 230                 235                 240 


Leu Ser Gln Glu Gly Ile Asn Ile Leu Thr His Leu Pro Lys Gly Ser 
                245                 250                 255     


Ala Glu Ala Glu Leu Met Ser Val Val Pro Val Phe Tyr Val Phe His 
            260                 265                 270         


Tyr Leu Glu Thr Gly Asn His Trp Asn Ile Phe His Ser Asp Pro Leu 
        275                 280                 285             


Ile Glu Lys Gln Lys Leu Lys Lys Lys Leu Lys Glu Gly Met Leu Ser 
    290                 295                 300                 


Ile Met Ser Tyr Arg Asn Ala Asp Tyr Ser Tyr Ser Val Trp Lys Gly 
305                 310                 315                 320 


Gly Ser Ala Ser Thr Trp Leu Thr Ala Phe Ala Leu Arg Val Leu Gly 
                325                 330                 335     


Gln Val Asn Lys Tyr Val Glu Gln Asn Gln Asn Ser Ile Cys Asn Ser 
            340                 345                 350         


Leu Leu Trp Leu Val Glu Asn Tyr Gln Leu Asp Asn Gly Ser Phe Lys 
        355                 360                 365             


Glu Asn Ser Gln Tyr Gln Pro Ile Lys Leu Gln Gly Thr Leu Pro Val 
    370                 375                 380                 


Glu Ala Arg Glu Asn Ser Leu Tyr Leu Thr Ala Phe Thr Val Ile Gly 
385                 390                 395                 400 


Ile Arg Lys Ala Phe Asp Ile Cys Pro Leu Val Lys Ile Asp Thr Ala 
                405                 410                 415     


Leu Ile Lys Ala Asp Asn Phe Leu Leu Glu Asn Thr Leu Pro Ala Gln 
            420                 425                 430         


Ser Thr Phe Thr Leu Ala Ile Ser Ala Tyr Ala Leu Ser Leu Gly Asp 
        435                 440                 445             


Lys Thr His Pro Gln Phe Arg Ser Ile Val Ser Ala Leu Lys Arg Glu 
    450                 455                 460                 


Ala Leu Val Lys Gly Asn Pro Pro Ile Tyr Arg Phe Trp Lys Asp Asn 
465                 470                 475                 480 


Leu Gln His Lys Asp Ser Ser Val Pro Asn Thr Gly Thr Ala Arg Met 
                485                 490                 495     


Val Glu Thr Thr Ala Tyr Ala Leu Leu Thr Ser Leu Asn Leu Lys Asp 
            500                 505                 510         


Ile Asn Tyr Val Asn Pro Val Ile Lys Trp Leu Ser Glu Glu Gln Arg 
        515                 520                 525             


Tyr Gly Gly Gly Phe Tyr Ser Thr Gln Asp Thr Ile Asn Ala Ile Glu 
    530                 535                 540                 


Gly Leu Thr Glu Tyr Ser Leu Leu Val Lys Gln Leu Arg Leu Ser Met 
545                 550                 555                 560 


Asp Ile Asp Val Ser Tyr Lys His Lys Gly Ala Leu His Asn Tyr Lys 
                565                 570                 575     


Met Thr Asp Lys Asn Phe Leu Gly Arg Pro Val Glu Val Leu Leu Asn 
            580                 585                 590         


Asp Asp Leu Ile Val Ser Thr Gly Phe Gly Ser Gly Leu Ala Thr Val 
        595                 600                 605             


His Val Thr Thr Val Val His Lys Thr Ser Thr Ser Glu Glu Val Cys 
    610                 615                 620                 


Ser Phe Tyr Leu Lys Ile Asp Thr Gln Asp Ile Glu Ala Ser His Tyr 
625                 630                 635                 640 


Arg Gly Tyr Gly Asn Ser Asp Tyr Lys Arg Ile Val Ala Cys Ala Ser 
                645                 650                 655     


Tyr Lys Pro Ser Arg Glu Glu Ser Ser Ser Gly Ser Ser His Ala Val 
            660                 665                 670         


Met Asp Ile Ser Leu Pro Thr Gly Ile Ser Ala Asn Glu Glu Asp Leu 
        675                 680                 685             


Lys Ala Leu Val Glu Gly Val Asp Gln Leu Phe Thr Asp Tyr Gln Ile 
    690                 695                 700                 


Lys Asp Gly His Val Ile Leu Gln Leu Asn Ser Ile Pro Ser Ser Asp 
705                 710                 715                 720 


Phe Leu Cys Val Arg Phe Arg Ile Phe Glu Leu Phe Glu Val Gly Phe 
                725                 730                 735     


Leu Ser Pro Ala Thr Phe Thr Val Tyr Glu Tyr His Arg Pro Asp Lys 
            740                 745                 750         


Gln Cys Thr Met Phe Tyr Ser Thr Ser Asn Ile Lys Ile Gln Lys Val 
        755                 760                 765             


Cys Glu Gly Ala Ala Cys Lys Cys Val Glu Ala Asp Cys Gly Gln Met 
    770                 775                 780                 


Gln Glu Glu Leu Asp Leu Thr Ile Ser Ala Glu Thr Arg Lys Gln Thr 
785                 790                 795                 800 


Ala Cys Lys Pro Glu Ile Ala Tyr Ala Tyr Lys Val Ser Ile Thr Ser 
                805                 810                 815     


Ile Thr Val Glu Asn Val Phe Val Lys Tyr Lys Ala Thr Leu Leu Asp 
            820                 825                 830         


Ile Tyr Lys Thr Gly Glu Ala Val Ala Glu Lys Asp Ser Glu Ile Thr 
        835                 840                 845             


Phe Ile Lys Lys Val Thr Cys Thr Asn Ala Glu Leu Val Lys Gly Arg 
    850                 855                 860                 


Gln Tyr Leu Ile Met Gly Lys Glu Ala Leu Gln Ile Lys Tyr Asn Phe 
865                 870                 875                 880 



Ser Phe Arg Tyr Ile Tyr Pro Leu Asp Ser Leu Thr Trp Ile Glu Tyr 
                885                 890                 895     


Trp Pro Arg Asp Thr Thr Cys Ser Ser Cys Gln Ala Phe Leu Ala Asn 
            900                 905                 910         


Leu Asp Glu Phe Ala Glu Asp Ile Phe Leu Asn Gly Cys 
        915                 920                 925 
 




