
                                SEQUENCE LISTING

<110> THE J. DAVID GLADSTONE INSTITUTES
      HUANG, YADONG
      Xu, Qin
      Bien-Ly, Nga
      WEISGRABER, KARL H.
      Chen, Ligong
      Peters-Libeu, Clare

<120> Antibody Specific for Apolipoprotein and
  Methods of Use Thereof
  

<130> GLAD-386WO

<150> US 61/309,280       
<151> 2010-03-01  

<160> 41

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H1 heavy chain variable region

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gln Phe Tyr Tyr Tyr Gly Gly Ser Tyr Asp Tyr Phe Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
        115                 120         


<210> 2
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 2
Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser
 1               5                  10  


<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 3
Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 4
Gln Phe Tyr Tyr Tyr Gly Gly Ser Tyr Asp Tyr Phe Asp Tyr
 1               5                  10                  


<210> 5
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H1 light chain variable region

<400> 5
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
 1               5                  10                  15      
Asp Ser Val Ser Leu Ala Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Tyr Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr
65                  70                  75                  80  
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu
                85                  90                  95      
Thr Phe Gly Val Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 6
Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His
 1               5                  10      


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 7
Tyr Ala Tyr Gln Ser Ile Ser
 1               5          


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 8
Gln Gln Ser Asn Ser Trp Pro Leu Thr
 1               5                  


<210> 9
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3H1 heavy chain variable region

<400> 9
gaggtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc 60
tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact 120
ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtagtta cacctactat 180
ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac 240
ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagacaattt 300
tattactacg gtggtagcta cgactacttt gactactggg gccaagggac cacgctcacc 360
gtctcg                                                            366

<210> 10
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3H1 light chain variable region

<400> 10
gacattgtgc tgacccagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt 60
cttgcctgca gggccagcca aagtattagc aacaacctac actggtatca acaaaaatca 120
catgagtctc caaggcttct catcaaatat gcttaccagt ccatctctgg gatcccctcc 180
aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact 240
gaagattttg gaatgtattt ctgtcaacag agtaacagct ggcctctcac gttcggtgtg 300
gggaccaagc tggaaataaa acgt                                        324

<210> 11
<211> 299
<212> PRT
<213> Homo sapiens

<400> 11
Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu Arg Gln
 1               5                  10                  15      
Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg
            20                  25                  30          
Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln
        35                  40                  45              
Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met
    50                  55                  60                  
Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu
65                  70                  75                  80  
Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu
                85                  90                  95      
Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Arg
            100                 105                 110         
Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln
        115                 120                 125             
Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu
    130                 135                 140                 
Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala
145                 150                 155                 160 
Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala
                165                 170                 175     
Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala
            180                 185                 190         
Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln
        195                 200                 205             
Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg
    210                 215                 220                 
Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu Val Arg
225                 230                 235                 240 
Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala Glu Ala
                245                 250                 255     
Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met
            260                 265                 270         
Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala Val Gly
        275                 280                 285             
Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His
    290                 295                 


<210> 12
<211> 317
<212> PRT
<213> Homo sapiens

<400> 12
Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys
 1               5                  10                  15      
Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu
            20                  25                  30          
Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu
        35                  40                  45              
Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln
    50                  55                  60                  
Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala
65                  70                  75                  80  
Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu
                85                  90                  95      
Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser
            100                 105                 110         
Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp
        115                 120                 125             
Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu
    130                 135                 140                 
Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg
145                 150                 155                 160 
Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg
                165                 170                 175     
Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu
            180                 185                 190         
Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val
        195                 200                 205             
Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg
    210                 215                 220                 
Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly
225                 230                 235                 240 
Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu
                245                 250                 255     
Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala
            260                 265                 270         
Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu
        275                 280                 285             
Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala
    290                 295                 300                 
Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His
305                 310                 315         


<210> 13
<211> 43
<212> PRT
<213> Homo sapiens

<400> 13
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys
 1               5                  10                  15      
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile
            20                  25                  30          
Gly Leu Met Val Gly Gly Val Val Ile Ala Thr
        35                  40              


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 14
Gly Ser Arg Thr Arg Asp Arg Leu Asp
 1               5                  


<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 15
Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met
 1               5                  10      


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 16
Ser Arg Thr Arg Asp Arg Leu
 1               5          


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 17
Ser Trp Phe Glu Pro Leu Val Glu Asp
 1               5                  


<210> 18
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 18
Gly Ser Arg Thr Arg Asp Arg Leu Asp Glu Val
 1               5                  10      


<210> 19
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 19
Leu Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met
 1               5                  10          


<210> 20
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 20
Lys Glu Gln Val Ala Glu Val Arg Ala Lys Leu Glu Glu Gln Ala Gln
 1               5                  10                  15      
Gln Ile Arg Leu Gln Ala Glu Ala Phe Gln Ala Arg
            20                  25              


<210> 21
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 21
Gly Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala
 1               5                  10                  15      
Glu Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln
            20                  25                  30          
Ala Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val
        35                  40                  45              
Glu Asp Met
    50      


<210> 22
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 22
Gly Ser Gly Gly Ser
 1               5  


<210> 23
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 23
Gly Gly Gly Ser
 1              


<210> 24
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 24
Gly Gly Ser Gly
 1              


<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 25
Gly Gly Ser Gly Gly
 1               5  


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 26
Gly Ser Gly Ser Gly
 1               5  


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 27
Gly Ser Gly Gly Gly
 1               5  


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 28
Gly Gly Gly Ser Gly
 1               5  


<210> 29
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 29
Gly Ser Ser Ser Gly
 1               5  


<210> 30
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 30
Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
 1               5                  10  


<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 31
Asp Tyr Lys Asp Asp Asp Asp Lys
 1               5              


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 32
Cys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu
 1               5                  10      


<210> 33
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 33
His His His His His
 1               5  


<210> 34
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 34
His His His His His His
 1               5      


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 35
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu
 1               5                  10  


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 36
Asp Tyr Lys Asp Asp Asp Asp Lys
 1               5              


<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 37
Trp Ser His Pro Gln Phe Glu Lys
 1               5              


<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 38
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
 1               5                  


<210> 39
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 39
Arg Tyr Ile Arg Ser
 1               5  


<210> 40
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 40
Phe His His Thr
 1              


<210> 41
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 41
Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg
 1               5                  10                  15      
Ala
    

