                         SEQUENCE LISTING

<110>  Dr. Rentschler Holding GmbH & Co. KG
 
<120>  Naturally occurring autoantibodies against alpha-synuclein that 
       inhibit the aggregation and cytotoxicity of alpha-synuclein

<130>  46742P WO

<160>  164   

<170>  PatentIn version 3.3

<210>  1
<211>  140
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(140)
<223>  alpha-Synuclein

<400>  1

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  2
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(220)
<223>  light chain sequence

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Arg Leu Thr Glu Glu Lys Gly 
                85                  90                  95      


Trp Met Tyr Leu Gly Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  3
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  4
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  4

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  5
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  6
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  6

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
1               5                   10                  15      


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            20                  25                  30          


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        35                  40                  45              


Thr Val 
    50  


<210>  7
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Leu Gln Leu Gln Glu Ser Gly Ser Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser 
            20                  25  


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  9
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  10
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  10

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
1               5                   10                  15      


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            20                  25                  30          


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        35                  40                  45              


Thr Val 
    50  


<210>  11
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  12
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  12

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  13
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  13

Trp Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  14
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  14

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
1               5                   10                  15      


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
            20                  25                  30          


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        35                  40                  45              


Thr Val 
    50  


<210>  15
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  17
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
1               5                   10                  15      


<210>  19
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  20
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  20

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  21
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  22
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
1               5                   10                  15      


<210>  23
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  24
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  24

Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile Tyr 
1               5                   10                  15  


<210>  25
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  26
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  26

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
1               5                   10                  15      


<210>  27
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  anti-alpha-Synuclein HCv Type 1, CDR1, consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Phe or Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be Ala, Asn or Tyr

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be Ala, Gly, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be Ile or Met

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be His, Asn or Ser

<400>  27

Gly Phe Thr Xaa Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Phe Thr Phe Ser Asp Ala Trp Ile Asn 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Phe Thr Phe Ser Ser Tyr Ala Met His 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   10  


<210>  35
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  36
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  36

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  37

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  39
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  39

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  40

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  42
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  42

Tyr Ile Ser Ser Ser Gly Gly Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  43

Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Met Val Arg Gly Val Thr Lys Pro Phe Asp Tyr 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Tyr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Gly Tyr 
1               5                   10          


<210>  46
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Leu Val Asp Tyr Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr 
1               5                   10                  


<210>  47
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Arg Gly Phe Gly Tyr Cys Ser Ser Thr Ser Cys His Thr Glu Asp 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  48
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Arg His Pro Gly Tyr Cys Ser Ser Thr Ser Cys Phe Val Arg Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  49
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Arg Arg Gly Ile Ala Ala Thr Ala Gly Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  50
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Trp Gly Ile Val Asp Thr Ala Met Val Pro Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  51
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  51

Glu Ala Pro Ser Ser Gly Trp Tyr Pro Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  52
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  52

Glu His Arg Gly Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Thr Lys His 
1               5                   10                  15      


Gly Gly Ser Asn Asp Tyr 
            20          


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  53

Glu Arg Tyr Tyr Tyr Met Asp Val 
1               5               


<210>  54
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Gly Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Leu Pro Trp Tyr 
1               5                   10                  15  


<210>  55
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Thr Asp Thr Glu Ser Val Ala Ala Pro Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Gly Val Ala Gly Arg Phe Asp Tyr 
1               5               


<210>  57
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Val Val Pro Ala Ala Glu Ser Trp Phe Asp Pro 
1               5                   10          


<210>  58
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  58

Lys Asp Gly Ser Gly Ser Tyr Tyr His Tyr Tyr Tyr Tyr Val Met Asp 
1               5                   10                  15      


Val 
    


<210>  59
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  59

Lys Thr Tyr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Gly Tyr 
1               5                   10              


<210>  60
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Asp Ile Ala Ala Ala Ala Pro Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  61
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  61

Ser Gly Ala Ser Leu Arg Ala Phe Asp Ile 
1               5                   10  


<210>  62
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  62

Ser Gly Tyr Tyr Tyr Pro Leu Asp Tyr 
1               5                   


<210>  63
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  63

Tyr Cys Ser Ser Thr Ser Cys Ser Ser Glu Tyr Phe Gly His 
1               5                   10                  


<210>  64
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  64

Tyr Tyr Tyr Asp Ser Ser Ala Val Glu Gly Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  65
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  anti-alpha-Synuclein HCv Type 2, CDR1, consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be Ser or Tyr

<400>  65

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Xaa Trp Ser 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Ser Trp Ser 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  67

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  68
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  anti-alpha-Synuclein HCv Type 2, CDR2, consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be His or Tyr

<400>  68

Tyr Ile Tyr Xaa Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  69
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  69

Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  70
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  70

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  71
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  71

Ala Gly Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10  


<210>  72
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  72

Ala His Pro Val Arg Gly Ser Gly Ser Tyr Tyr Asn Arg Asn Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Met Asp Val 
            20          


<210>  73
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  73

Gly Ser Arg Glu Gly Tyr Gly Asp Arg Ile Asp Tyr 
1               5                   10          


<210>  74
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  74

Gly Thr Glu Tyr Cys Thr Asn Gly Ala Cys Tyr Met Gly Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Met Asp Val 
            20      


<210>  75
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Thr Glu Tyr Cys Thr Asn Gly Val Cys Tyr Met Gly Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Met Asp Val 
            20      


<210>  76
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  76

Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  77

Gly Tyr Ile Ile Ala Asn Tyr Tyr Ile His 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  78

Gly Tyr Ile Ile Thr Asn Tyr Tyr Ile His 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  79

Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  80

Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   10  


<210>  81
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  anti-alpha-Synuclein HCv Type 3, CDR2, consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Gly, Ile or Trp

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Ile, Asn or Thr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be Ile, Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Phe, Gly, His or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be Ala, Gly, Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be Asn or Ser

<400>  81

Xaa Ile Xaa Pro Xaa Xaa Gly Xaa Xaa Xaa Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  82
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  82

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  83

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  84

Ile Ile Thr Pro Ser His Gly Ala Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  85

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  86

Ala Lys Asp Tyr Asp Phe Trp Arg Gly Ser Thr Gly Met Arg Tyr Leu 
1               5                   10                  15      


Asp Val 
        


<210>  87
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  87

Asp Lys Arg Cys Ser Ser Thr Ser Cys Gln Pro Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  88
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  88

Asp Ser Gly Ser Ser Gly Trp Tyr Val Pro Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  15      


<210>  89
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  89

Pro Ile Gly Gly Gly Pro Ser Gly Trp Tyr Glu Thr Ser Cys Phe Asp 
1               5                   10                  15      


Pro 
    


<210>  90
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  90

Thr Ser Tyr Gly Asp Ser Ser Ser Ser Ser Tyr Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  91
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  91

Val Asp Tyr Ser Asn Tyr Val Val Asp Tyr 
1               5                   10  


<210>  92
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  92

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  93
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  93

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  94
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  anti-alpha-Synuclein LCv Type 1, CDR3, consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may not be present or may be Thr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be Arg, Trp or Tyr

<400>  94

Met Gln Ala Leu Gln Xaa Xaa Xaa Thr 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Gln Ala Leu Gln Thr Pro Arg Thr 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Gln Ala Leu Gln Thr Pro Trp Thr 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Gln Ala Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  98
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Gln Ala Thr Gln Phe Arg Thr 
1               5               


<210>  99
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  anti-alpha-Synuclein LCv Type 2, CDR1, consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may not be present or may be Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be Asn or Tyr

<400>  99

Arg Ala Ser Gln Ser Val Ser Ser Xaa Xaa Leu Ala 
1               5                   10          


<210>  100
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  100

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  101
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  101

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  102
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  102

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  103
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  anti-alpha-Synuclein LCv Type 2, CDR2, consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Asn, Ser or Thr

<400>  103

Xaa Ala Ser Xaa Arg Ala Thr 
1               5           


<210>  104
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  104

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  105
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  105

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  106
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  106

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  107
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  107

Gln Gln Arg Ser Asn Trp Pro Pro Thr 
1               5                   


<210>  108
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  108

Gln Gln Arg Ser Asn Trp Pro Pro Tyr Thr 
1               5                   10  


<210>  109
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  109

Gln Gln Tyr Gly Ser Ser Trp Thr 
1               5               


<210>  110
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  110

Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210>  111
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  111

Gln Gln Tyr Asn Asn Trp Pro Pro Met Tyr Thr 
1               5                   10      


<210>  112
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  112

Gln Gln Tyr Asn Asn Trp Pro Arg Thr 
1               5                   


<210>  113
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  113

Gln Gln Tyr Asn Asn Trp Trp Thr 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  114

Gln Gln Tyr Asn Asn Trp Tyr Thr 
1               5               


<210>  115
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  anti-alpha-Synuclein LCv Type 3, CDR1, consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be Ala or Met

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be Arg or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be Asp, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be Ala or Gly

<400>  115

Arg Xaa Ser Gln Xaa Ile Xaa Xaa Xaa Leu Xaa 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  116

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  117
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  117

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  118
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  118

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  119
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  119

Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  120
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  120

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  121

Arg Met Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  122
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  122

Arg Met Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  123
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  123

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  124
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  124

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  125
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  125

Ala Ala Ser Thr Leu Val Ser 
1               5           


<210>  126
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  126

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  127
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  127

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  128
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  128

Leu Gly Asp Tyr Asn Tyr Pro Tyr Thr 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  129

Leu Gln Asp Asn Asn Tyr Pro Arg Thr 
1               5                   


<210>  130
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  130

Leu Gln Asp Tyr Asn Tyr Pro Tyr Thr 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  131

Leu Gln His Asn Ser Tyr Pro Phe Thr 
1               5                   


<210>  132
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  132

Leu Gln His Asn Ser Tyr Pro Val Thr 
1               5                   


<210>  133
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  133

Gln Gln Ala Asn Ser Phe Pro Ile Thr 
1               5                   


<210>  134
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  134

Gln Gln Ala Asn Ser Phe Pro Leu Thr 
1               5                   


<210>  135
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  135

Gln Gln Leu Asn Ser Tyr Pro Leu Phe Thr 
1               5                   10  


<210>  136
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  136

Gln Gln Tyr Asp Asn Leu Pro Pro Phe Thr 
1               5                   10  


<210>  137
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Gln Tyr Asn Ser Tyr Pro Val Thr 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  138

Gln Gln Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  139
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  139

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  140
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  140

Gln Gln Tyr Asn Ser Tyr Ser Arg Lys Tyr Thr 
1               5                   10      


<210>  141
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  141

Leu Gln Asp Tyr Asn Tyr Pro Leu Thr 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  142

Gln Gln Tyr Asn Ser Tyr Leu Tyr Thr 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  143

Gln Gln Leu Asn Ser Tyr Pro Arg Thr 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  144

Leu Arg Asp Tyr Asn Tyr Pro Leu Thr 
1               5                   


<210>  145
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  145

Arg Leu Thr Glu Glu Lys Gly Trp Met Tyr Leu Gly Tyr Thr 
1               5                   10                  


<210>  146
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  146

Gln Gln Arg Ser Asn Trp Pro Pro Ile Thr 
1               5                   10  


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  147

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  148
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  148

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro 
        115             


<210>  149
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  149

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro 
        115             


<210>  150
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  150

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Val Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Asn Cys Gly Cys Thr Ile Cys Leu His Leu Pro 
        115                 120                 


<210>  151
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  151

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Tyr Gln 
            100                 105                 110         


Thr Asn Cys Gly Cys Thr Ile Cys Leu His Leu Pro 
        115                 120                 


<210>  152
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 1

<400>  152

Met Asp Val Phe Met Lys Gly Leu Ser Lys 
1               5                   10  


<210>  153
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 7

<400>  153

Val Leu Tyr Val Gly Ser Lys Thr Lys Glu 
1               5                   10  


<210>  154
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 13

<400>  154

Gly Val Thr Ala Val Ala Gln Lys Thr Asn 
1               5                   10  


<210>  155
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 16

<400>  155

Ala Thr Gly Phe Val Lys Lys Asp Gln Leu 
1               5                   10  


<210>  156
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 31

<400>  156

Val Leu Tyr Val Gly Ser Lys Met Lys Glu 
1               5                   10  


<210>  157
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 49

<400>  157

Met Met Val Gly Lys Ser Asp Leu Lys Phe 
1               5                   10  


<210>  158
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 50

<400>  158

Leu Glu Ser Val Gly Ala Lys Val Lys Gly 
1               5                   10  


<210>  159
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 55

<400>  159

Val Tyr Ser Val Leu Lys Lys Glu Thr Gly 
1               5                   10  


<210>  160
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  decamer peptide spot No. 64

<400>  160

Leu Lys Phe Thr Lys Asp Val Gln Gly Ala 
1               5                   10  


<210>  161
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  hexamer peptide spot No. 77

<400>  161

Val Thr Ala Val Ala Gln 
1               5       


<210>  162
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  hexamer peptide spot No. 83

<400>  162

Thr Gly Phe Val Lys Lys 
1               5       


<210>  163
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  hexamer peptide spot No. 95

<400>  163

Thr Gly Met Val Lys Lys 
1               5       


<210>  164
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  hexamer peptide spot No. 107

<400>  164

Lys Thr Lys Gly Phe Val 
1               5       


