                         SEQUENCE LISTING

<110>  Migone et al.
 
<120>  Antibodies That Specifically Bind to DR3

<130>  PF622PCT

<150>  61/308,804
<151>  2010-02-26

<160>  28    

<170>  PatentIn version 3.3

<210>  1
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  1
atggagcagc ggccgcgggg ctgcgcggcg gtggcggcgg cgctcctcct ggtgctgctg     60

ggggcccggg cccagggcgg cactcgtagc cccaggtgtg actgtgccgg tgacttccac    120

aagaagattg gtctgttttg ttgcagaggc tgcccagcgg ggcactacct gaaggcccct    180

tgcacggagc cctgcggcaa ctccacctgc cttgtgtgtc cccaagacac cttcttggcc    240

tgggagaacc accataattc tgaatgtgcc cgctgccagg cctgtgatga gcaggcctcc    300

caggtggcgc tggagaactg ttcagcagtg gccgacaccc gctgtggctg taagccaggc    360

tggtttgtgg agtgccaggt cagccaatgt gtcagcagtt cacccttcta ctgccaacca    420

tgcctagact gcggggccct gcaccgccac acacggctac tctgttcccg cagagatact    480

gactgtggga cctgcctgcc tggcttctat gaacatggcg atggctgcgt gtcctgcccc    540

acgagcaccc tggggagctg tccagagcgc tgtgccgctg tctgtggctg gaggcagatg    600

ttctgggtcc aggtgctcct ggctggcctt gtggtccccc tcctgcttgg ggccaccctg    660

acctacacat accgccactg ctggcctcac aagcccctgg ttactgcaga tgaagctggg    720

atggaggctc tgaccccacc accggccacc catctgtcac ccttggacag cgcccacacc    780

cttctagcac ctcctgacag cagtgagaag atctgcaccg tccagttggt gggtaacagc    840

tggacccctg gctaccccga gacccaggag gcgctctgcc cgcaggtgac atggtcctgg    900

gaccagttgc ccagcagagc tcttggcccc gctgctgcgc ccacactctc gccagagtcc    960

ccagccggct cgccagccat gatgctgcag ccgggcccgc agctctacga cgtgatggac   1020

gcggtcccag cgcggcgctg gaaggagttc gtgcgcacgc tggggctgcg cgaggcagag   1080

atcgaagccg tggaggtgga gatcggccgc ttccgagacc agcagtacga gatgctcaag   1140

cgctggcgcc agcagcagcc cgcgggcctc ggagccgttt acgcggccct ggagcgcatg   1200

gggctggacg gctgcgtgga agacttgcgc agccgcctgc agcgcggccc gtga         1254

<210>  2
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      

Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          

Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              

Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  

Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  

Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      

Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         

Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             

Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 

Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 

Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     

Val Ser Cys Pro Thr Ser Thr Leu Gly Ser Cys Pro Glu Arg Cys Ala 
            180                 185                 190         

Ala Val Cys Gly Trp Arg Gln Met Phe Trp Val Gln Val Leu Leu Ala 
        195                 200                 205             

Gly Leu Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr 
    210                 215                 220                 

Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly 
225                 230                 235                 240 

Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp 
                245                 250                 255     

Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys 
            260                 265                 270         

Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr 
        275                 280                 285             

Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro 
    290                 295                 300                 

Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser 
305                 310                 315                 320 

Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr 
                325                 330                 335     

Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg 
            340                 345                 350         

Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile 
        355                 360                 365             

Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln 
    370                 375                 380                 

Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met 
385                 390                 395                 400 

Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly 
                405                 410                 415     

Pro 
    
<210>  3
<211>  1755
<212>  DNA
<213>  Homo sapiens

<400>  3
gatgcgcata aaagcgaagt ggcgcatcgc tttaaagatc tgggcgaaga aaactttaaa     60

gcgctggtgc tgattgcgtt tgcgcagtat ctgcagcagt gcccgtttga agatcatgtg    120

aaactggtga acgaagtgac cgaatttgcg aaaacctgcg tggcggatga aagcgcggaa    180

aactgcgata aaagcctgca taccctgttt ggcgataaac tgtgcaccgt ggcgaccctg    240

cgcgaaacct atggcgaaat ggcggattgc tgcgcgaaac aggaaccgga acgcaacgaa    300

tgctttctgc agcataaaga tgataacccg aacctgccgc gcctggtgcg cccggaagtg    360

gatgtgatgt gcaccgcgtt tcatgataac gaagaaacct ttctgaaaaa atatctgtat    420

gaaattgcgc gccgccatcc gtatttttat gcgccggaac tgctgttttt tgcgaaacgc    480

tataaagcgg cgtttaccga atgctgccag gcggcggata aagcggcgtg cctgctgccg    540

aaactggatg aactgcgcga tgaaggcaaa gcgagcagcg cgaaacagcg cctgaaatgc    600

gcgagcctgc agaaatttgg cgaacgcgcg tttaaagcgt gggcggtggc gcgcctgagc    660

cagcgctttc cgaaagcgga atttgcggaa gtgagcaaac tggtgaccga tctgaccaaa    720

gtgcataccg aatgctgcca tggcgatctg ctggaatgcg cggatgatcg cgcggatctg    780

gcgaaatata tttgcgaaaa ccaggatagc attagcagca aactgaaaga atgctgcgaa    840

aaaccgctgc tggaaaaaag ccattgcatt gcggaagtgg aaaacgatga aatgccggcg    900

gatctgccga gcctggcggc ggattttgtg gaaagcaaag atgtgtgcaa aaactatgcg    960

gaagcgaaag atgtgtttct gggcatgttt ctgtatgaat atgcgcgccg ccatccggat   1020

tatagcgtgg tgctgctgct gcgcctggcg aaaacctatg aaaccaccct ggaaaaatgc   1080

tgcgcggcgg cggatccgca tgaatgctat gcgaaagtgt ttgatgaatt taaaccgctg   1140

gtggaagaac cgcagaacct gattaaacag aactgcgaac tgtttgaaca gctgggcgaa   1200

tataaatttc agaacgcgct gctggtgcgc tataccaaaa aagtgccgca ggtgagcacc   1260

ccgaccctgg tggaagtgag ccgcaacctg ggcaaagtgg gcagcaaatg ctgcaaacat   1320

ccggaagcga aacgcatgcc gtgcgcggaa gattatctga gcgtggtgct gaaccagctg   1380

tgcgtgctgc atgaaaaaac cccggtgagc gatcgcgtga ccaaatgctg caccgaaagc   1440

ctggtgaacc gccgcccgtg ctttagcgcg ctggaagtgg atgaaaccta tgtgccgaaa   1500

gaatttaacg cggaaacctt tacctttcat gcggatattt gcaccctgag cgaaaaagaa   1560

cgccagatta aaaaacagac cgcgctggtg gaactggtga aacataaacc gaaagcgacc   1620

aaagaacagc tgaaagcggt gatggatgat tttgcggcgt ttgtggaaaa atgctgcaaa   1680

gcggatgata aagaaacctg ctttgcggaa gaaggcaaaa aactggtggc ggcgagccag   1740

gcggcgctgg gcctg                                                    1755

<210>  4
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      

Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          

Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              

Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  

Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  

Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      

Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         

Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             

Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 

Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 

Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     

Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         

Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             

Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 

Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 

Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     

Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         

Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             

Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 

Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 

Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     

Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         

Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             

Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 

Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 

Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     

Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         

Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             

Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 

Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 

Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     

Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         

Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             

Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 

Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 

Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     

Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 

<210>  5
<211>  1824
<212>  DNA
<213>  Mus musculus

<400>  5
atgaaatggg tgacctttct gctgctgctg tttgtgagcg gcagcgcgtt tagccgcggc     60

gtgtttcgcc gcgaagcgca taaaagcgaa attgcgcatc gctataacga tctgggcgaa    120

cagcatttta aaggcctggt gctgattgcg tttagccagt atctgcagaa atgcagctat    180

gatgaacatg cgaaactggt gcaggaagtg accgattttg cgaaaacctg cgtggcggat    240

gaaagcgcgg cgaactgcga taaaagcctg cataccctgt ttggcgataa actgtgcgcg    300

attccgaacc tgcgcgaaaa ctatggcgaa ctggcggatt gctgcaccaa acaggaaccg    360

gaacgcaacg aatgctttct gcagcataaa gatgataacc cgagcctgcc gccgtttgaa    420

cgcccggaag cggaagcgat gtgcaccagc tttaaagaaa acccgaccac ctttatgggc    480

cattatctgc atgaagtggc gcgccgccat ccgtattttt atgcgccgga actgctgtat    540

tatgcggaac agtataacga aattctgacc cagtgctgcg cggaagcgga taaagaaagc    600

tgcctgaccc cgaaactgga tggcgtgaaa gaaaaagcgc tggtgagcag cgtgcgccag    660

cgcatgaaat gcagcagcat gcagaaattt ggcgaacgcg cgtttaaagc gtgggcggtg    720

gcgcgcctga gccagacctt tccgaacgcg gattttgcgg aaattaccaa actggcgacc    780

gatctgacca aagtgaacaa agaatgctgc catggcgatc tgctggaatg cgcggatgat    840

cgcgcggaac tggcgaaata tatgtgcgaa aaccaggcga ccattagcag caaactgcag    900

acctgctgcg ataaaccgct gctgaaaaaa gcgcattgcc tgagcgaagt ggaacatgat    960

accatgccgg cggatctgcc ggcgattgcg gcggattttg tggaagatca ggaagtgtgc   1020

aaaaactatg cggaagcgaa agatgtgttt ctgggcacct ttctgtatga atatagccgc   1080

cgccatccgg attatagcgt gagcctgctg ctgcgcctgg cgaaaaaata tgaagcgacc   1140

ctggaaaaat gctgcgcgga agcgaacccg ccggcgtgct atggcaccgt gctggcggaa   1200

tttcagccgc tggtggaaga accgaaaaac ctggtgaaaa ccaactgcga tctgtatgaa   1260

aaactgggcg aatatggctt tcagaacgcg attctggtgc gctataccca gaaagcgccg   1320

caggtgagca ccccgaccct ggtggaagcg gcgcgcaacc tgggccgcgt gggcaccaaa   1380

tgctgcaccc tgccggaaga tcagcgcctg ccgtgcgtgg aagattatct gagcgcgatt   1440

ctgaaccgcg tgtgcctgct gcatgaaaaa accccggtga gcgaacatgt gaccaaatgc   1500

tgcagcggca gcctggtgga acgccgcccg tgctttagcg cgctgaccgt ggatgaaacc   1560

tatgtgccga aagaatttaa agcggaaacc tttacctttc atagcgatat ttgcaccctg   1620

ccggaaaaag aaaaacagat taaaaaacag accgcgctgg cggaactggt gaaacataaa   1680

ccgaaagcga ccgcggaaca gctgaaaacc gtgatggatg attttgcgca gtttctggat   1740

acctgctgca aagcggcgga taaagatacc tgctttagca ccgaaggccc gaacctggtg   1800

acccgctgca aagataccct ggcg                                          1824

<210>  6
<211>  584
<212>  PRT
<213>  Mus musculus

<400>  6

Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
1               5                   10                  15      

Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          

Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              

Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  

Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  

Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      

Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         

Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             

Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 

Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 

Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     

Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         

Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             

Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 

Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 

Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     

Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         

Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             

Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 

Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 

Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     

Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         

Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             

Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 

Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 

Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     

Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         

Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             

Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 

Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 

Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     

Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         

Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             

Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 

Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 

Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     

Thr Arg Cys Lys Asp Thr Leu Ala 
            580                 

<210>  7
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Asn Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  8

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              

Ser Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asn Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  10
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              

Ser Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  11
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Leu 
        35                  40                  45              

Ala Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Asn Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Leu 
        35                  40                  45              

Ala Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              

Ser Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Asn Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              

Ser Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              

Ser Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Asn Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  17

Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu His 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asn Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  18

Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu His 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  19
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<400>  19

Glu Val Met Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Thr Ile Thr Ser Gly Gly Ser Tyr Ile Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu His 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Lys Asp Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  20
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  20

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      

Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          

Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              

Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  

Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  

Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      

Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<220>  
<221>  SITE
<222>  (108)..(108)
<223>  Xaa is Leu or Val

<400>  21

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          

Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              

Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  

Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  

Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      

Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
            100                 105                 110     

<210>  22
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<220>  
<221>  SITE
<222>  (108)..(108)
<223>  Xaa is Leu or Val

<400>  22

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          

Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              

Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  

Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  

Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      

Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
            100                 105                 110     

<210>  23
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<220>  
<221>  SITE
<222>  (108)..(108)
<223>  Xaa is Leu or Val

<400>  23

Asp Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      

Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          

Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              

Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  

Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  

Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      

Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
            100                 105                 110     

<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized murine antibody

<220>  
<221>  SITE
<222>  (108)..(108)
<223>  Xaa is Leu or Val

<400>  24

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      

Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          

Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              

Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  

Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  

Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      

Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
            100                 105                 110     

<210>  25
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  26
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  26

Arg Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
1               5                   10                  15      

Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            20                  25                  30          

Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        35                  40                  45              

Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    50                  55                  60                  

Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
65                  70                  75                  80  

Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                85                  90                  95      

Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            100                 105                 110         

Glu Cys 
        
<210>  27
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val 
        
<210>  28
<211>  102
<212>  PRT
<213>  Mus musculus

<400>  28

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      

Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  

Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  

Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      

Ile Glu Pro Arg Gly Pro 
            100         
