                         SEQUENCE LISTING

<110>  SCHEPENS EYE RESEARCH INSTITUTE
 
<120>  THERAPEUTIC COMPOSITIONS FOR THE TREATMENT OF DRY EYE DISEASE

<130>  28967/45367B PCT

<150>  61/308,091
<151>  2010-02-25

<150>  61/329,845
<151>  2010-04-30

<150>  61/331,278
<151>  2010-05-04

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gly or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Tyr or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Trp or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Leu or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Thr or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ile or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Trp or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Glyor a conservative substitution thereof

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Gly or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Tyr or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Trp or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Leu or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Thr or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ile or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Trp or a conservative substitution thereof

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Glyor a conservative substitution thereof

<400>  2

Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Xaa Gly Tyr Trp Leu Thr Ile Trp Gly Xaa 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(10)
<223>  Cyclic peptide

<400>  4

Cys Gly Tyr Trp Leu Thr Ile Trp Gly Cys 
1               5                   10  


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(13)

<400>  5

Cys Ala Ser Glu Leu Gly Lys Ser Thr Asn Thr Phe Cys 
1               5                   10              


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(8)

<400>  6

Cys Asn Glu Glu Ser Leu Ile Cys 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(11)

<400>  7

Cys Ile Ser Val Pro Leu Thr Ser Val Pro Cys 
1               5                   10      


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(13)

<400>  8

Cys Ala Ser Glu Leu Gly Lys Ser Thr Asn Thr Phe Cys Lys Pro Pro 
1               5                   10                  15      


Cys 
    


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (2)..(9)

<400>  9

Cys Cys Asn Glu Glu Ser Leu Ile Cys 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(9)

<400>  10

Cys Ser Val Pro Leu Thr Ser Val Cys 
1               5                   


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(7)

<400>  11

Cys Val Pro Leu Thr Ser Cys 
1               5           


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(6)

<400>  12

Cys Val Pro Leu Thr Cys 
1               5       


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(10)

<400>  13

Cys Ile Ser Val Pro Leu Ser Val Pro Cys 
1               5                   10  


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(9)

<400>  14

Cys Ile Ser Val Pro Leu Val Pro Cys 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Ser Gly Tyr Trp Trp Asp Thr Trp Phe 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Ser Cys Tyr Trp Arg Asp Thr Trp Phe 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Lys Val Gly Trp Ser Ser Pro Asp Trp 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Phe Val Gly Trp Thr Lys Val Leu Gly 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Tyr Ser Ser Ser Met Arg Trp Arg His 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Arg Trp Arg Gly Asn Ala Tyr Pro Gly 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  21

Ser Ala Val Phe Arg Gly Arg Trp Leu 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Trp Phe Ser Ala Ser Leu Arg Phe Arg 
1               5                   


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  23

Trp Gln Leu Gly Arg Asn Trp Ile 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  24

Val Glu Val Gln Ile Thr Gln Glu 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  25

Ala Gly Lys Ala Ser Ser Leu Trp 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Arg Ala Leu Asp Ser Ala Leu Ala 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Tyr Gly Phe Glu Ala Ala Trp 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Tyr Gly Phe Leu Trp Gly Met 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Ser Arg Trp Arg Ile Leu Gly 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  30

His Lys Trp Gln Lys Arg Gln 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  31

Met Asp Pro Trp Gly Gly Trp 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Arg Lys Val Trp Asp Ile Arg 
1               5           


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  33

Val Trp Asp His Gly Val 
1               5       


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  34

Cys Trp Gln Leu Gly Arg Asn Trp Ile Cys 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  35

Cys Val Glu Val Gln Ile Thr Gln Glu Cys 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Cys Ala Gly Lys Ala Ser Ser Leu Trp Cys 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  37

Cys Arg Ala Leu Asp Ser Ala Leu Ala Cys 
1               5                   10  


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  38

Cys Tyr Gly Phe Glu Ala Ala Trp Cys 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  39

Cys Tyr Gly Phe Leu Trp Gly Met Cys 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  40

Cys Ser Arg Trp Arg Ile Leu Gly Cys 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  41

Cys His Lys Trp Gln Lys Arg Gln Cys 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  42

Cys Met Asp Pro Trp Gly Gly Trp Cys 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Cys Arg Lys Val Trp Asp Ile Arg Cys 
1               5                   


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Cys Val Trp Asp His Gly Val Cys 
1               5               


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Cys Gly Gln Met Cys Thr Val Trp Cys Ser Ser Gly Cys 
1               5                   10              


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Gly Tyr Trp Xaa Xaa Xaa Trp 
1               5           


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Gly Tyr Trp Xaa Xaa Xaa Trp Xaa 
1               5               


<210>  48
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Pro Arg 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Gln Gly Ala Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Val Ser Gly Phe Gly Pro Trp Gly Arg Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  49
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ser Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg His 
            20                  25                  30          


Thr Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asp Asp His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  50
<211>  2292
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2292)

<400>  50
atg gag agc aag gtg ctg ctg gcc gtc gcc ctg tgg ctc tgc gtg gag         48
Met Glu Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu           
1               5                   10                  15                

acc cgg gcc gcc tct gtg ggt ttg cct agt gtt tct ctt gat ctg ccc         96
Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro           
            20                  25                  30                    

agg ctc agc ata caa aaa gac ata ctt aca att aag gct aat aca act        144
Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr           
        35                  40                  45                        

ctt caa att act tgc agg gga cag agg gac ttg gac tgg ctt tgg ccc        192
Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro           
    50                  55                  60                            

aat aat cag agt ggc agt gag caa agg gtg gag gtg act gag tgc agc        240
Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser           
65                  70                  75                  80            

gat ggc ctc ttc tgt aag aca ctc aca att cca aaa gtg atc gga aat        288
Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn           
                85                  90                  95                

gac act gga gcc tac aag tgc ttc tac cgg gaa act gac ttg gcc tcg        336
Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser           
            100                 105                 110                   

gtc att tat gtc tat gtt caa gat tac aga tct cca ttt att gct tct        384
Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser           
        115                 120                 125                       

gtt agt gac caa cat gga gtc gtg tac att act gag aac aaa aac aaa        432
Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys           
    130                 135                 140                           

act gtg gtg att cca tgt ctc ggg tcc att tca aat ctc aac gtg tca        480
Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser           
145                 150                 155                 160           

ctt tgt gca aga tac cca gaa aag aga ttt gtt cct gat ggt aac aga        528
Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg           
                165                 170                 175               

att tcc tgg gac agc aag aag ggc ttt act att ccc agc tac atg atc        576
Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile           
            180                 185                 190                   

agc tat gct ggc atg gtc ttc tgt gaa gca aaa att aat gat gaa agt        624
Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser           
        195                 200                 205                       

tac cag tct att atg tac ata gtt gtc gtt gta ggg tat agg att tat        672
Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr           
    210                 215                 220                           

gat gtg gtt ctg agt ccg tct cat gga att gaa cta tct gtt gga gaa        720
Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu           
225                 230                 235                 240           

aag ctt gtc tta aat tgt aca gca aga act gaa cta aat gtg ggg att        768
Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile           
                245                 250                 255               

gac ttc aac tgg gaa tac cct tct tcg aag cat cag cat aag aaa ctt        816
Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu           
            260                 265                 270                   

gta aac cga gac cta aaa acc cag tct ggg agt gag atg aag aaa ttt        864
Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe           
        275                 280                 285                       

ttg agc acc tta act ata gat ggt gta acc cgg agt gac caa gga ttg        912
Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu           
    290                 295                 300                           

tac acc tgt gca gca tcc agt ggg ctg atg acc aag aag aac agc aca        960
Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr           
305                 310                 315                 320           

ttt gtc agg gtc cat gaa aaa cct ttt gtt gct ttt gga agt ggc atg       1008
Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met           
                325                 330                 335               

gaa tct ctg gtg gaa gcc acg gtg ggg gag cgt gtc aga atc cct gcg       1056
Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala           
            340                 345                 350                   

aag tac ctt ggt tac cca ccc cca gaa ata aaa tgg tat aaa aat gga       1104
Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly           
        355                 360                 365                       

ata ccc ctt gag tcc aat cac aca att aaa gcg ggg cat gta ctg acg       1152
Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr           
    370                 375                 380                           

att atg gaa gtg agt gaa aga gac aca gga aat tac act gtc atc ctt       1200
Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu           
385                 390                 395                 400           

acc aat ccc att tca aag gag aag cag agc cat gtg gtc tct ctg gtt       1248
Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val           
                405                 410                 415               

gtg tat gtc cca ccc cag att ggt gag aaa tct cta atc tct cct gtg       1296
Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val           
            420                 425                 430                   

gat tcc tac cag tac ggc acc act caa acg ctg aca tgt acg gtc tat       1344
Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr           
        435                 440                 445                       

gcc att cct ccc ccg cat cac atc cac tgg tat tgg cag ttg gag gaa       1392
Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu           
    450                 455                 460                           

gag tgc gcc aac gag ccc agc caa gct gtc tca gtg aca aac cca tac       1440
Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr           
465                 470                 475                 480           

cct tgt gaa gaa tgg aga agt gtg gag gac ttc cag gga gga aat aaa       1488
Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys           
                485                 490                 495               

att gaa gtt aat aaa aat caa ttt gct cta att gaa gga aaa aac aaa       1536
Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys           
            500                 505                 510                   

act gta agt acc ctt gtt atc caa gcg gca aat gtg tca gct ttg tac       1584
Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr           
        515                 520                 525                       

aaa tgt gaa gcg gtc aac aaa gtc ggg aga gga gag agg gtg atc tcc       1632
Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser           
    530                 535                 540                           

ttc cac gtg acc agg ggt cct gaa att act ttg caa cct gac atg cag       1680
Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln           
545                 550                 555                 560           

ccc act gag cag gag agc gtg tct ttg tgg tgc act gca gac aga tct       1728
Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser           
                565                 570                 575               

acg ttt gag aac ctc aca tgg tac aag ctt ggc cca cag cct ctg cca       1776
Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro           
            580                 585                 590                   

atc cat gtg gga gag ttg ccc aca cct gtt tgc aag aac ttg gat act       1824
Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr           
        595                 600                 605                       

ctt tgg aaa ttg aat gcc acc atg ttc tct aat agc aca aat gac att       1872
Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile           
    610                 615                 620                           

ttg atc atg gag ctt aag aat gca tcc ttg cag gac caa gga gac tat       1920
Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr           
625                 630                 635                 640           

gtc tgc ctt gct caa gac agg aag acc aag aaa aga cat tgc gtg gtc       1968
Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val           
                645                 650                 655               

agg cag ctc aca gtc cta gag cgt gtg gca ccc acg atc aca gga aac       2016
Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn           
            660                 665                 670                   

ctg gag aat cag acg aca agt att ggg gaa agc atc gaa gtc tca tgc       2064
Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys           
        675                 680                 685                       

acg gca tct ggg aat ccc cct cca cag atc atg tgg ttt aaa gat aat       2112
Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn           
    690                 695                 700                           

gag acc ctt gta gaa gac tca ggc att gta ttg aag gat ggg aac cgg       2160
Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg           
705                 710                 715                 720           

aac ctc act atc cgc aga gtg agg aag gag gac gaa ggc ctc tac acc       2208
Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr           
                725                 730                 735               

tgc cag gca tgc agt gtt ctt ggc tgt gca aaa gtg gag gca ttt ttc       2256
Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe           
            740                 745                 750                   

ata ata gaa ggt gcc cag gaa aag acg aac ttg gaa                       2292
Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu                           
        755                 760                                           


<210>  51
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu 
        755                 760                 


<210>  52
<211>  4195
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (20)..(3913)

<400>  52
ccacgcgcag cggccggag atg cag cgg ggc gcc gcg ctg tgc ctg cga ctg        52
                     Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu          
                     1               5                   10               

tgg ctc tgc ctg gga ctc ctg gac ggc ctg gtg agt ggc tac tcc atg        100
Trp Leu Cys Leu Gly Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met           
            15                  20                  25                    

acc ccc ccg acc ttg aac atc acg gag gag tca cac gtc atc gac acc        148
Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr           
        30                  35                  40                        

ggt gac agc ctg tcc atc tcc tgc agg gga cag cac ccc ctc gag tgg        196
Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp           
    45                  50                  55                            

gct tgg cca gga gct cag gag gcg cca gcc acc gga gac aag gac agc        244
Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser           
60                  65                  70                  75            

gag gac acg ggg gtg gtg cga gac tgc gag ggc aca gac gcc agg ccc        292
Glu Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro           
                80                  85                  90                

tac tgc aag gtg ttg ctg ctg cac gag gta cat gcc aac gac aca ggc        340
Tyr Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn Asp Thr Gly           
            95                  100                 105                   

agc tac gtc tgc tac tac aag tac atc aag gca cgc atc gag ggc acc        388
Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr           
        110                 115                 120                       

acg gcc gcc agc tcc tac gtg ttc gtg aga gac ttt gag cag cca ttc        436
Thr Ala Ala Ser Ser Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe           
    125                 130                 135                           

atc aac aag cct gac acg ctc ttg gtc aac agg aag gac gcc atg tgg        484
Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp           
140                 145                 150                 155           

gtg ccc tgt ctg gtg tcc atc ccc ggc ctc aat gtc acg ctg cgc tcg        532
Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser           
                160                 165                 170               

caa agc tcg gtg ctg tgg cca gac ggg cag gag gtg gtg tgg gat gac        580
Gln Ser Ser Val Leu Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp           
            175                 180                 185                   

cgg cgg ggc atg ctc gtg tcc acg cca ctg ctg cac gat gcc ctg tac        628
Arg Arg Gly Met Leu Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr           
        190                 195                 200                       

ctg cag tgc gag acc acc tgg gga gac cag gac ttc ctt tcc aac ccc        676
Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro           
    205                 210                 215                           

ttc ctg gtg cac atc aca ggc aac gag ctc tat gac atc cag ctg ttg        724
Phe Leu Val His Ile Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu           
220                 225                 230                 235           

ccc agg aag tcg ctg gag ctg ctg gta ggg gag aag ctg gtc ctg aac        772
Pro Arg Lys Ser Leu Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn           
                240                 245                 250               

tgc acc gtg tgg gct gag ttt aac tca ggt gtc acc ttt gac tgg gac        820
Cys Thr Val Trp Ala Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp           
            255                 260                 265                   

tac cca ggg aag cag gca gag cgg ggt aag tgg gtg ccc gag cga cgc        868
Tyr Pro Gly Lys Gln Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg           
        270                 275                 280                       

tcc cag cag acc cac aca gaa ctc tcc agc atc ctg acc atc cac aac        916
Ser Gln Gln Thr His Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn           
    285                 290                 295                           

gtc agc cag cac gac ctg ggc tcg tat gtg tgc aag gcc aac aac ggc        964
Val Ser Gln His Asp Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly           
300                 305                 310                 315           

atc cag cga ttt cgg gag agc acc gag gtc att gtg cat gaa aat ccc       1012
Ile Gln Arg Phe Arg Glu Ser Thr Glu Val Ile Val His Glu Asn Pro           
                320                 325                 330               

ttc atc agc gtc gag tgg ctc aaa gga ccc atc ctg gag gcc acg gca       1060
Phe Ile Ser Val Glu Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala           
            335                 340                 345                   

gga gac gag ctg gtg aag ctg ccc gtg aag ctg gca gcg tac ccc ccg       1108
Gly Asp Glu Leu Val Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro           
        350                 355                 360                       

ccc gag ttc cag tgg tac aag gat gga aag gca ctg tcc ggg cgc cac       1156
Pro Glu Phe Gln Trp Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His           
    365                 370                 375                           

agt cca cat gcc ctg gtg ctc aag gag gtg aca gag gcc agc aca ggc       1204
Ser Pro His Ala Leu Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly           
380                 385                 390                 395           

acc tac acc ctc gcc ctg tgg aac tcc gct gct ggc ctg agg cgc aac       1252
Thr Tyr Thr Leu Ala Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn           
                400                 405                 410               

atc agc ctg gag ctg gtg gtg aat gtg ccc ccc cag ata cat gag aag       1300
Ile Ser Leu Glu Leu Val Val Asn Val Pro Pro Gln Ile His Glu Lys           
            415                 420                 425                   

gag gcc tcc tcc ccc agc atc tac tcg cgt cac agc cgc cag gcc ctc       1348
Glu Ala Ser Ser Pro Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu           
        430                 435                 440                       

acc tgc acg gcc tac ggg gtg ccc ctg cct ctc agc atc cag tgg cac       1396
Thr Cys Thr Ala Tyr Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His           
    445                 450                 455                           

tgg cgg ccc tgg aca ccc tgc aag atg ttt gcc cag cgt agt ctc cgg       1444
Trp Arg Pro Trp Thr Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg           
460                 465                 470                 475           

cgg cgg cag cag caa gac ctc atg cca cag tgc cgt gac tgg agg gcg       1492
Arg Arg Gln Gln Gln Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala           
                480                 485                 490               

gtg acc acg cag gat gcc gtg aac ccc atc gag agc ctg gac acc tgg       1540
Val Thr Thr Gln Asp Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp           
            495                 500                 505                   

acc gag ttt gtg gag gga aag aat aag act gtg agc aag ctg gtg atc       1588
Thr Glu Phe Val Glu Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile           
        510                 515                 520                       

cag aat gcc aac gtg tct gcc atg tac aag tgt gtg gtc tcc aac aag       1636
Gln Asn Ala Asn Val Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys           
    525                 530                 535                           

gtg ggc cag gat gag cgg ctc atc tac ttc tat gtg acc acc atc ccc       1684
Val Gly Gln Asp Glu Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro           
540                 545                 550                 555           

gac ggc ttc acc atc gaa tcc aag cca tcc gag gag cta cta gag ggc       1732
Asp Gly Phe Thr Ile Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly           
                560                 565                 570               

cag ccg gtg ctc ctg agc tgc caa gcc gac agc tac aag tac gag cat       1780
Gln Pro Val Leu Leu Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His           
            575                 580                 585                   

ctg cgc tgg tac cgc ctc aac ctg tcc acg ctg cac gat gcg cac ggg       1828
Leu Arg Trp Tyr Arg Leu Asn Leu Ser Thr Leu His Asp Ala His Gly           
        590                 595                 600                       

aac ccg ctt ctg ctc gac tgc aag aac gtg cat ctg ttc gcc acc cct       1876
Asn Pro Leu Leu Leu Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro           
    605                 610                 615                           

ctg gcc gcc agc ctg gag gag gtg gca cct ggg gcg cgc cac gcc acg       1924
Leu Ala Ala Ser Leu Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr           
620                 625                 630                 635           

ctc agc ctg agt atc ccc cgc gtc gcg ccc gag cac gag ggc cac tat       1972
Leu Ser Leu Ser Ile Pro Arg Val Ala Pro Glu His Glu Gly His Tyr           
                640                 645                 650               

gtg tgc gaa gtg caa gac cgg cgc agc cat gac aag cac tgc cac aag       2020
Val Cys Glu Val Gln Asp Arg Arg Ser His Asp Lys His Cys His Lys           
            655                 660                 665                   

aag tac ctg tcg gtg cag gcc ctg gaa gcc cct cgg ctc acg cag aac       2068
Lys Tyr Leu Ser Val Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn           
        670                 675                 680                       

ttg acc gac ctc ctg gtg aac gtg agc gac tcg ctg gag atg cag tgc       2116
Leu Thr Asp Leu Leu Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys           
    685                 690                 695                           

ttg gtg gcc gga gcg cac gcg ccc agc atc gtg tgg tac aaa gac gag       2164
Leu Val Ala Gly Ala His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu           
700                 705                 710                 715           

agg ctg ctg gag gaa aag tct gga gtc gac ttg gcg gac tcc aac cag       2212
Arg Leu Leu Glu Glu Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln           
                720                 725                 730               

aag ctg agc atc cag cgc gtg cgc gag gag gat gcg gga cgc tat ctg       2260
Lys Leu Ser Ile Gln Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu           
            735                 740                 745                   

tgc agc gtg tgc aac gcc aag ggc tgc gtc aac tcc tcc gcc agc gtg       2308
Cys Ser Val Cys Asn Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val           
        750                 755                 760                       

gcc gtg gaa ggc tcc gag gat aag ggc agc atg gag atc gtg atc ctt       2356
Ala Val Glu Gly Ser Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu           
    765                 770                 775                           

gtc ggt acc ggc gtc atc gct gtc ttc ttc tgg gtc ctc ctc ctc ctc       2404
Val Gly Thr Gly Val Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu           
780                 785                 790                 795           

atc ttc tgt aac atg agg agg ccg gcc cac gca gac atc aag acg ggc       2452
Ile Phe Cys Asn Met Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly           
                800                 805                 810               

tac ctg tcc atc atc atg gac ccc ggg gag gtg cct ctg gag gag caa       2500
Tyr Leu Ser Ile Ile Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln           
            815                 820                 825                   

tgc gaa tac ctg tcc tac gat gcc agc cag tgg gaa ttc ccc cga gag       2548
Cys Glu Tyr Leu Ser Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu           
        830                 835                 840                       

cgg ctg cac ctg ggg aga gtg ctc ggc tac ggc gcc ttc ggg aag gtg       2596
Arg Leu His Leu Gly Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val           
    845                 850                 855                           

gtg gaa gcc tcc gct ttc ggc atc cac aag ggc agc agc tgt gac acc       2644
Val Glu Ala Ser Ala Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr           
860                 865                 870                 875           

gtg gcc gtg aaa atg ctg aaa gag ggc gcc acg gcc agc gag cac cgc       2692
Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg           
                880                 885                 890               

gcg ctg atg tcg gag ctc aag atc ctc att cac atc ggc aac cac ctc       2740
Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly Asn His Leu           
            895                 900                 905                   

aac gtg gtc aac ctc ctc ggg gcg tgc acc aag ccg cag ggc ccc ctc       2788
Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu           
        910                 915                 920                       

atg gtg atc gtg gag ttc tgc aag tac ggc aac ctc tcc aac ttc ctg       2836
Met Val Ile Val Glu Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu           
    925                 930                 935                           

cgc gcc aag cgg gac gcc ttc agc ccc tgc gcg gag aag tct ccc gag       2884
Arg Ala Lys Arg Asp Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu           
940                 945                 950                 955           

cag cgc gga cgc ttc cgc gcc atg gtg gag ctc gcc agg ctg gat cgg       2932
Gln Arg Gly Arg Phe Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg           
                960                 965                 970               

agg cgg ccg ggg agc agc gac agg gtc ctc ttc gcg cgg ttc tcg aag       2980
Arg Arg Pro Gly Ser Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys           
            975                 980                 985                   

acc gag ggc gga gcg agg cgg gct tct cca gac caa gaa  gct gag gac      3028
Thr Glu Gly Gly Ala Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp          
        990                 995                 1000                      

ctg tgg  ctg agc ccg ctg acc  atg gaa gat ctt gtc  tgc tac agc        3073
Leu Trp  Leu Ser Pro Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser            
    1005                 1010                 1015                        

ttc cag  gtg gcc aga ggg atg  gag ttc ctg gct tcc  cga aag tgc        3118
Phe Gln  Val Ala Arg Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys            
    1020                 1025                 1030                        

atc cac  aga gac ctg gct gct  cgg aac att ctg ctg  tcg gaa agc        3163
Ile His  Arg Asp Leu Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser            
    1035                 1040                 1045                        

gac gtg  gtg aag atc tgt gac  ttt ggc ctt gcc cgg  gac atc tac        3208
Asp Val  Val Lys Ile Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr            
    1050                 1055                 1060                        

aaa gac  cct gac tac gtc cgc  aag ggc agt gcc cgg  ctg ccc ctg        3253
Lys Asp  Pro Asp Tyr Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu            
    1065                 1070                 1075                        

aag tgg  atg gcc cct gaa agc  atc ttc gac aag gtg  tac acc acg        3298
Lys Trp  Met Ala Pro Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr            
    1080                 1085                 1090                        

cag agt  gac gtg tgg tcc ttt  ggg gtg ctt ctc tgg  gag atc ttc        3343
Gln Ser  Asp Val Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe            
    1095                 1100                 1105                        

tct ctg  ggg gcc tcc ccg tac  cct ggg gtg cag atc  aat gag gag        3388
Ser Leu  Gly Ala Ser Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu            
    1110                 1115                 1120                        

ttc tgc  cag cgg ctg aga gac  ggc aca agg atg agg  gcc ccg gag        3433
Phe Cys  Gln Arg Leu Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu            
    1125                 1130                 1135                        

ctg gcc  act ccc gcc ata cgc  cgc atc atg ctg aac  tgc tgg tcc        3478
Leu Ala  Thr Pro Ala Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser            
    1140                 1145                 1150                        

gga gac  ccc aag gcg aga cct  gca ttc tcg gag ctg  gtg gag atc        3523
Gly Asp  Pro Lys Ala Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile            
    1155                 1160                 1165                        

ctg ggg  gac ctg ctc cag ggc  agg ggc ctg caa gag  gaa gag gag        3568
Leu Gly  Asp Leu Leu Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu            
    1170                 1175                 1180                        

gtc tgc  atg gcc ccg cgc agc  tct cag agc tca gaa  gag ggc agc        3613
Val Cys  Met Ala Pro Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser            
    1185                 1190                 1195                        

ttc tcg  cag gtg tcc acc atg  gcc cta cac atc gcc  cag gct gac        3658
Phe Ser  Gln Val Ser Thr Met  Ala Leu His Ile Ala  Gln Ala Asp            
    1200                 1205                 1210                        

gct gag  gac agc ccg cca agc  ctg cag cgc cac agc  ctg gcc gcc        3703
Ala Glu  Asp Ser Pro Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala            
    1215                 1220                 1225                        

agg tat  tac aac tgg gtg tcc  ttt ccc ggg tgc ctg  gcc aga ggg        3748
Arg Tyr  Tyr Asn Trp Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly            
    1230                 1235                 1240                        

gct gag  acc cgt ggt tcc tcc  agg atg aag aca ttt  gag gaa ttc        3793
Ala Glu  Thr Arg Gly Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe            
    1245                 1250                 1255                        

ccc atg  acc cca acg acc tac  aaa ggc tct gtg gac  aac cag aca        3838
Pro Met  Thr Pro Thr Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr            
    1260                 1265                 1270                        

gac agt  ggg atg gtg ctg gcc  tcg gag gag ttt gag  cag ata gag        3883
Asp Ser  Gly Met Val Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu            
    1275                 1280                 1285                        

agc agg  cat aga caa gaa agc  ggc ttc agg tagctgaagc agagagagag       3933
Ser Arg  His Arg Gln Glu Ser  Gly Phe Arg                                 
    1290                 1295                                             

aaggcagcat acgtcagcat tttcttctct gcacttataa gaaagatcaa agactttaag     3993

actttcgcta tttcttctac tgctatctac tacaaacttc aaagaggaac caggaggaca     4053

agaggagcat gaaagtggac aaggagtgtg accactgaag caccacaggg aaggggttag     4113

gcctccggat gactgcgggc aggcctggat aatatccagc ctcccacaag aagctggtgg     4173

agcagagtgt tccctgactc ct                                              4195


<210>  53
<211>  1298
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Arg 
    1295             


<210>  54
<211>  4795
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (20)..(4111)

<400>  54
ccacgcgcag cggccggag atg cag cgg ggc gcc gcg ctg tgc ctg cga ctg        52
                     Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu          
                     1               5                   10               

tgg ctc tgc ctg gga ctc ctg gac ggc ctg gtg agt ggc tac tcc atg        100
Trp Leu Cys Leu Gly Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met           
            15                  20                  25                    

acc ccc ccg acc ttg aac atc acg gag gag tca cac gtc atc gac acc        148
Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr           
        30                  35                  40                        

ggt gac agc ctg tcc atc tcc tgc agg gga cag cac ccc ctc gag tgg        196
Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp           
    45                  50                  55                            

gct tgg cca gga gct cag gag gcg cca gcc acc gga gac aag gac agc        244
Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser           
60                  65                  70                  75            

gag gac acg ggg gtg gtg cga gac tgc gag ggc aca gac gcc agg ccc        292
Glu Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro           
                80                  85                  90                

tac tgc aag gtg ttg ctg ctg cac gag gta cat gcc aac gac aca ggc        340
Tyr Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn Asp Thr Gly           
            95                  100                 105                   

agc tac gtc tgc tac tac aag tac atc aag gca cgc atc gag ggc acc        388
Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr           
        110                 115                 120                       

acg gcc gcc agc tcc tac gtg ttc gtg aga gac ttt gag cag cca ttc        436
Thr Ala Ala Ser Ser Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe           
    125                 130                 135                           

atc aac aag cct gac acg ctc ttg gtc aac agg aag gac gcc atg tgg        484
Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp           
140                 145                 150                 155           

gtg ccc tgt ctg gtg tcc atc ccc ggc ctc aat gtc acg ctg cgc tcg        532
Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser           
                160                 165                 170               

caa agc tcg gtg ctg tgg cca gac ggg cag gag gtg gtg tgg gat gac        580
Gln Ser Ser Val Leu Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp           
            175                 180                 185                   

cgg cgg ggc atg ctc gtg tcc acg cca ctg ctg cac gat gcc ctg tac        628
Arg Arg Gly Met Leu Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr           
        190                 195                 200                       

ctg cag tgc gag acc acc tgg gga gac cag gac ttc ctt tcc aac ccc        676
Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro           
    205                 210                 215                           

ttc ctg gtg cac atc aca ggc aac gag ctc tat gac atc cag ctg ttg        724
Phe Leu Val His Ile Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu           
220                 225                 230                 235           

ccc agg aag tcg ctg gag ctg ctg gta ggg gag aag ctg gtc ctg aac        772
Pro Arg Lys Ser Leu Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn           
                240                 245                 250               

tgc acc gtg tgg gct gag ttt aac tca ggt gtc acc ttt gac tgg gac        820
Cys Thr Val Trp Ala Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp           
            255                 260                 265                   

tac cca ggg aag cag gca gag cgg ggt aag tgg gtg ccc gag cga cgc        868
Tyr Pro Gly Lys Gln Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg           
        270                 275                 280                       

tcc cag cag acc cac aca gaa ctc tcc agc atc ctg acc atc cac aac        916
Ser Gln Gln Thr His Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn           
    285                 290                 295                           

gtc agc cag cac gac ctg ggc tcg tat gtg tgc aag gcc aac aac ggc        964
Val Ser Gln His Asp Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly           
300                 305                 310                 315           

atc cag cga ttt cgg gag agc acc gag gtc att gtg cat gaa aat ccc       1012
Ile Gln Arg Phe Arg Glu Ser Thr Glu Val Ile Val His Glu Asn Pro           
                320                 325                 330               

ttc atc agc gtc gag tgg ctc aaa gga ccc atc ctg gag gcc acg gca       1060
Phe Ile Ser Val Glu Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala           
            335                 340                 345                   

gga gac gag ctg gtg aag ctg ccc gtg aag ctg gca gcg tac ccc ccg       1108
Gly Asp Glu Leu Val Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro           
        350                 355                 360                       

ccc gag ttc cag tgg tac aag gat gga aag gca ctg tcc ggg cgc cac       1156
Pro Glu Phe Gln Trp Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His           
    365                 370                 375                           

agt cca cat gcc ctg gtg ctc aag gag gtg aca gag gcc agc aca ggc       1204
Ser Pro His Ala Leu Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly           
380                 385                 390                 395           

acc tac acc ctc gcc ctg tgg aac tcc gct gct ggc ctg agg cgc aac       1252
Thr Tyr Thr Leu Ala Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn           
                400                 405                 410               

atc agc ctg gag ctg gtg gtg aat gtg ccc ccc cag ata cat gag aag       1300
Ile Ser Leu Glu Leu Val Val Asn Val Pro Pro Gln Ile His Glu Lys           
            415                 420                 425                   

gag gcc tcc tcc ccc agc atc tac tcg cgt cac agc cgc cag gcc ctc       1348
Glu Ala Ser Ser Pro Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu           
        430                 435                 440                       

acc tgc acg gcc tac ggg gtg ccc ctg cct ctc agc atc cag tgg cac       1396
Thr Cys Thr Ala Tyr Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His           
    445                 450                 455                           

tgg cgg ccc tgg aca ccc tgc aag atg ttt gcc cag cgt agt ctc cgg       1444
Trp Arg Pro Trp Thr Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg           
460                 465                 470                 475           

cgg cgg cag cag caa gac ctc atg cca cag tgc cgt gac tgg agg gcg       1492
Arg Arg Gln Gln Gln Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala           
                480                 485                 490               

gtg acc acg cag gat gcc gtg aac ccc atc gag agc ctg gac acc tgg       1540
Val Thr Thr Gln Asp Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp           
            495                 500                 505                   

acc gag ttt gtg gag gga aag aat aag act gtg agc aag ctg gtg atc       1588
Thr Glu Phe Val Glu Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile           
        510                 515                 520                       

cag aat gcc aac gtg tct gcc atg tac aag tgt gtg gtc tcc aac aag       1636
Gln Asn Ala Asn Val Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys           
    525                 530                 535                           

gtg ggc cag gat gag cgg ctc atc tac ttc tat gtg acc acc atc ccc       1684
Val Gly Gln Asp Glu Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro           
540                 545                 550                 555           

gac ggc ttc acc atc gaa tcc aag cca tcc gag gag cta cta gag ggc       1732
Asp Gly Phe Thr Ile Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly           
                560                 565                 570               

cag ccg gtg ctc ctg agc tgc caa gcc gac agc tac aag tac gag cat       1780
Gln Pro Val Leu Leu Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His           
            575                 580                 585                   

ctg cgc tgg tac cgc ctc aac ctg tcc acg ctg cac gat gcg cac ggg       1828
Leu Arg Trp Tyr Arg Leu Asn Leu Ser Thr Leu His Asp Ala His Gly           
        590                 595                 600                       

aac ccg ctt ctg ctc gac tgc aag aac gtg cat ctg ttc gcc acc cct       1876
Asn Pro Leu Leu Leu Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro           
    605                 610                 615                           

ctg gcc gcc agc ctg gag gag gtg gca cct ggg gcg cgc cac gcc acg       1924
Leu Ala Ala Ser Leu Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr           
620                 625                 630                 635           

ctc agc ctg agt atc ccc cgc gtc gcg ccc gag cac gag ggc cac tat       1972
Leu Ser Leu Ser Ile Pro Arg Val Ala Pro Glu His Glu Gly His Tyr           
                640                 645                 650               

gtg tgc gaa gtg caa gac cgg cgc agc cat gac aag cac tgc cac aag       2020
Val Cys Glu Val Gln Asp Arg Arg Ser His Asp Lys His Cys His Lys           
            655                 660                 665                   

aag tac ctg tcg gtg cag gcc ctg gaa gcc cct cgg ctc acg cag aac       2068
Lys Tyr Leu Ser Val Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn           
        670                 675                 680                       

ttg acc gac ctc ctg gtg aac gtg agc gac tcg ctg gag atg cag tgc       2116
Leu Thr Asp Leu Leu Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys           
    685                 690                 695                           

ttg gtg gcc gga gcg cac gcg ccc agc atc gtg tgg tac aaa gac gag       2164
Leu Val Ala Gly Ala His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu           
700                 705                 710                 715           

agg ctg ctg gag gaa aag tct gga gtc gac ttg gcg gac tcc aac cag       2212
Arg Leu Leu Glu Glu Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln           
                720                 725                 730               

aag ctg agc atc cag cgc gtg cgc gag gag gat gcg gga cgc tat ctg       2260
Lys Leu Ser Ile Gln Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu           
            735                 740                 745                   

tgc agc gtg tgc aac gcc aag ggc tgc gtc aac tcc tcc gcc agc gtg       2308
Cys Ser Val Cys Asn Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val           
        750                 755                 760                       

gcc gtg gaa ggc tcc gag gat aag ggc agc atg gag atc gtg atc ctt       2356
Ala Val Glu Gly Ser Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu           
    765                 770                 775                           

gtc ggt acc ggc gtc atc gct gtc ttc ttc tgg gtc ctc ctc ctc ctc       2404
Val Gly Thr Gly Val Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu           
780                 785                 790                 795           

atc ttc tgt aac atg agg agg ccg gcc cac gca gac atc aag acg ggc       2452
Ile Phe Cys Asn Met Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly           
                800                 805                 810               

tac ctg tcc atc atc atg gac ccc ggg gag gtg cct ctg gag gag caa       2500
Tyr Leu Ser Ile Ile Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln           
            815                 820                 825                   

tgc gaa tac ctg tcc tac gat gcc agc cag tgg gaa ttc ccc cga gag       2548
Cys Glu Tyr Leu Ser Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu           
        830                 835                 840                       

cgg ctg cac ctg ggg aga gtg ctc ggc tac ggc gcc ttc ggg aag gtg       2596
Arg Leu His Leu Gly Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val           
    845                 850                 855                           

gtg gaa gcc tcc gct ttc ggc atc cac aag ggc agc agc tgt gac acc       2644
Val Glu Ala Ser Ala Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr           
860                 865                 870                 875           

gtg gcc gtg aaa atg ctg aaa gag ggc gcc acg gcc agc gag cac cgc       2692
Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg           
                880                 885                 890               

gcg ctg atg tcg gag ctc aag atc ctc att cac atc ggc aac cac ctc       2740
Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly Asn His Leu           
            895                 900                 905                   

aac gtg gtc aac ctc ctc ggg gcg tgc acc aag ccg cag ggc ccc ctc       2788
Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu           
        910                 915                 920                       

atg gtg atc gtg gag ttc tgc aag tac ggc aac ctc tcc aac ttc ctg       2836
Met Val Ile Val Glu Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu           
    925                 930                 935                           

cgc gcc aag cgg gac gcc ttc agc ccc tgc gcg gag aag tct ccc gag       2884
Arg Ala Lys Arg Asp Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu           
940                 945                 950                 955           

cag cgc gga cgc ttc cgc gcc atg gtg gag ctc gcc agg ctg gat cgg       2932
Gln Arg Gly Arg Phe Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg           
                960                 965                 970               

agg cgg ccg ggg agc agc gac agg gtc ctc ttc gcg cgg ttc tcg aag       2980
Arg Arg Pro Gly Ser Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys           
            975                 980                 985                   

acc gag ggc gga gcg agg cgg gct tct cca gac caa gaa  gct gag gac      3028
Thr Glu Gly Gly Ala Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp          
        990                 995                 1000                      

ctg tgg  ctg agc ccg ctg acc  atg gaa gat ctt gtc  tgc tac agc        3073
Leu Trp  Leu Ser Pro Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser            
    1005                 1010                 1015                        

ttc cag  gtg gcc aga ggg atg  gag ttc ctg gct tcc  cga aag tgc        3118
Phe Gln  Val Ala Arg Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys            
    1020                 1025                 1030                        

atc cac  aga gac ctg gct gct  cgg aac att ctg ctg  tcg gaa agc        3163
Ile His  Arg Asp Leu Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser            
    1035                 1040                 1045                        

gac gtg  gtg aag atc tgt gac  ttt ggc ctt gcc cgg  gac atc tac        3208
Asp Val  Val Lys Ile Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr            
    1050                 1055                 1060                        

aaa gac  cct gac tac gtc cgc  aag ggc agt gcc cgg  ctg ccc ctg        3253
Lys Asp  Pro Asp Tyr Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu            
    1065                 1070                 1075                        

aag tgg  atg gcc cct gaa agc  atc ttc gac aag gtg  tac acc acg        3298
Lys Trp  Met Ala Pro Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr            
    1080                 1085                 1090                        

cag agt  gac gtg tgg tcc ttt  ggg gtg ctt ctc tgg  gag atc ttc        3343
Gln Ser  Asp Val Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe            
    1095                 1100                 1105                        

tct ctg  ggg gcc tcc ccg tac  cct ggg gtg cag atc  aat gag gag        3388
Ser Leu  Gly Ala Ser Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu            
    1110                 1115                 1120                        

ttc tgc  cag cgg ctg aga gac  ggc aca agg atg agg  gcc ccg gag        3433
Phe Cys  Gln Arg Leu Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu            
    1125                 1130                 1135                        

ctg gcc  act ccc gcc ata cgc  cgc atc atg ctg aac  tgc tgg tcc        3478
Leu Ala  Thr Pro Ala Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser            
    1140                 1145                 1150                        

gga gac  ccc aag gcg aga cct  gca ttc tcg gag ctg  gtg gag atc        3523
Gly Asp  Pro Lys Ala Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile            
    1155                 1160                 1165                        

ctg ggg  gac ctg ctc cag ggc  agg ggc ctg caa gag  gaa gag gag        3568
Leu Gly  Asp Leu Leu Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu            
    1170                 1175                 1180                        

gtc tgc  atg gcc ccg cgc agc  tct cag agc tca gaa  gag ggc agc        3613
Val Cys  Met Ala Pro Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser            
    1185                 1190                 1195                        

ttc tcg  cag gtg tcc acc atg  gcc cta cac atc gcc  cag gct gac        3658
Phe Ser  Gln Val Ser Thr Met  Ala Leu His Ile Ala  Gln Ala Asp            
    1200                 1205                 1210                        

gct gag  gac agc ccg cca agc  ctg cag cgc cac agc  ctg gcc gcc        3703
Ala Glu  Asp Ser Pro Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala            
    1215                 1220                 1225                        

agg tat  tac aac tgg gtg tcc  ttt ccc ggg tgc ctg  gcc aga ggg        3748
Arg Tyr  Tyr Asn Trp Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly            
    1230                 1235                 1240                        

gct gag  acc cgt ggt tcc tcc  agg atg aag aca ttt  gag gaa ttc        3793
Ala Glu  Thr Arg Gly Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe            
    1245                 1250                 1255                        

ccc atg  acc cca acg acc tac  aaa ggc tct gtg gac  aac cag aca        3838
Pro Met  Thr Pro Thr Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr            
    1260                 1265                 1270                        

gac agt  ggg atg gtg ctg gcc  tcg gag gag ttt gag  cag ata gag        3883
Asp Ser  Gly Met Val Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu            
    1275                 1280                 1285                        

agc agg  cat aga caa gaa agc  ggc ttc agc tgt aaa  gga cct ggc        3928
Ser Arg  His Arg Gln Glu Ser  Gly Phe Ser Cys Lys  Gly Pro Gly            
    1290                 1295                 1300                        

cag aat  gtg gct gtg acc agg  gca cac cct gac tcc  caa ggg agg        3973
Gln Asn  Val Ala Val Thr Arg  Ala His Pro Asp Ser  Gln Gly Arg            
    1305                 1310                 1315                        

cgg cgg  cgg cct gag cgg ggg  gcc cga gga ggc cag  gtg ttt tac        4018
Arg Arg  Arg Pro Glu Arg Gly  Ala Arg Gly Gly Gln  Val Phe Tyr            
    1320                 1325                 1330                        

aac agc  gag tat ggg gag ctg  tcg gag cca agc gag  gag gac cac        4063
Asn Ser  Glu Tyr Gly Glu Leu  Ser Glu Pro Ser Glu  Glu Asp His            
    1335                 1340                 1345                        

tgc tcc  ccg tct gcc cgc gtg  act ttc ttc aca gac  aac agc tac        4108
Cys Ser  Pro Ser Ala Arg Val  Thr Phe Phe Thr Asp  Asn Ser Tyr            
    1350                 1355                 1360                        

taa gcagcatcgg acaagacccc cagcacttgg gggttcaggc ccggcagggc            4161

gggcagaggg ctggaggccc aggctgggaa ctcatctggt tgaactctgg tggcacagga     4221

gtgtcctctt ccctctctgc agacttccca gctaggaaga gcaggactcc aggcccaagg     4281

ctcccggaat tccgtcacca cgactggcca gggcacgctc cagctgcccc ggcccctccc     4341

cctgagattc agatgtcatt tagttcagca tccgcaggtg ctggtcccgg ggccagcact     4401

tccatgggaa tgtctctttg gcgacctcct ttcatcacac tgggtggtgg cctggtccct     4461

gttttcccac gaggaatctg tgggtctggg agtcacacag tgttggaggt taaggcatac     4521

gagagcagag gtctcccaaa cgccctttcc tcctcaggca cacagctact ctccccacga     4581

gggctggctg gcctcaccca cccctgcaca gttgaaggga ggggctgtgt ttccatctca     4641

aagaaggcat ttgcagggtc ctcttctggg cctgaccaaa cagccaacta gcccctgggg     4701

tggccaccag tatgacagta ttatacgctg gcaacacaga ggcagcccgc acacctgcgc     4761

ctgggtgttg agagccatcc tgcaagtctt tttc                                 4795


<210>  55
<211>  1363
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Ser Cys Lys  Gly Pro Gly Gln Asn  Val Ala Val 
    1295                 1300                 1305             


Thr Arg  Ala His Pro Asp Ser  Gln Gly Arg Arg Arg  Arg Pro Glu 
    1310                 1315                 1320             


Arg Gly  Ala Arg Gly Gly Gln  Val Phe Tyr Asn Ser  Glu Tyr Gly 
    1325                 1330                 1335             


Glu Leu  Ser Glu Pro Ser Glu  Glu Asp His Cys Ser  Pro Ser Ala 
    1340                 1345                 1350             


Arg Val  Thr Phe Phe Thr Asp  Asn Ser Tyr 
    1355                 1360             


<210>  56
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  56

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Phe Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  57
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  57

Met Gly Trp Ser Gly Val Phe Leu Phe Leu Leu Ser Gly Ser Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Asn Gly Asp Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Thr Ser Tyr Tyr Gly Gly Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135         


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  58

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  59

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  60

Ser Gln Ser Thr His Val Pro Arg Thr 
1               5                   


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  61

Gly Tyr Ser Phe Thr Gly Tyr Asn Met Tyr 
1               5                   10  


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  62

Tyr Ile Asp Pro Tyr Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  63

Thr Ser Tyr Tyr Gly Gly Met Asp Tyr 
1               5                   


