                         SEQUENCE LISTING

<110>  Immunogen, Inc.
       AB, Olga
       TAVARES, Daniel
       RUI, Lingyun
       PAYNE, Gillian
       GOLDMAKHER, Viktor S.
 
<120>  Folate Receptor 1 Antibodies and Immunoconjugates and Uses 
       Thereof

<130>  2921.002PC04

<140>  To Be Assigned
<141>  Herewith

<150>  US 61/413,172 
<151>  2010-11-12

<150>  US 61/346,595 
<151>  2010-05-20

<150>  US 61/307,797
<151>  2010-02-24 

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC CDR1

<400>  1

Gly Tyr Phe Met Asn 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC CDR2

<400>  2

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC CDR3

<400>  3

Tyr Asp Gly Ser Arg Ala Met Asp Tyr 
1               5                   


<210>  4
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  5
<211>  440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC

<400>  5
aagcttgcca ccatgggttg gtcatgcatc atcctcttct tggttgcaac tgctaccgga       60

gtgcacagtc aggtacagct cgtgcagtcc ggcgccgagg tggtgaagcc tggtgccagc      120

gtgaagatct cctgtaaagc cagtggatac acattcaccg gttattttat gaattgggtg      180

aaacagagcc caggccaatc cctcgaatgg atagggcgaa tccacccata tgacggggac      240

accttttaca accagaaatt ccaggggaaa gccactctga cagtggacaa gagttccaac      300

actgcacaca tggagcttct ctccctgacc agcgaagact tcgctgttta ttactgtacc      360

cgttatgatg gttcccgtgc aatggactac tggggccaag ggaccactgt caccgtaagt      420

tccgccagca ccaagggccc                                                  440


<210>  6
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 HC

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLC CDR1

<400>  7

Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr Ser Leu Met His 
1               5                   10                  15  


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLC CDR2

<400>  8

Arg Ala Ser Asn Leu Glu Ala 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLC CDR3

<400>  9

Gln Gln Ser Arg Glu Tyr Pro Tyr Thr 
1               5                   


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLCv1.00

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLCv1.60

<400>  11

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  12
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 LCv1.00

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  13
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 LCv1.60

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  14
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMov19 LCv1.00 nucleic acid

<400>  14
gaattcgcca ccatgggctg gagctgcatt atcctttttc tggtagccac agctacaggc       60

gtgcatagcg atatcgtgct gacacaatcc cccctctctc tggccgtgtc actcggacag      120

cccgctatca tcagctgcaa agccagccag tctgtcagct tcgctggaac aagtcttatg      180

cattggtatc atcagaagcc tggccagcaa cccaggctgc tgatctatcg agcctcaaac      240

ttggaagcag gagtgccaga ccggttttct gggtccggga gtaaaaccga ttttacactt      300

aatatctcac ctgtcgaggc cgaggacgcc gccacctact actgtcagca gagccgagag      360

tacccttaca cttttggcgg tgggactaaa ctggaaataa aacgtacg                   408


<210>  15
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMov19 LCv1.60

<400>  15
gaattcgcca ccatgggctg gtcttgtatc atcctgtttc tggtggccac cgcaaccggt       60

gttcactccg acattgtgct gacacagtcc cccctttcac tggctgtatc cctcggccag      120

cccgctatca tcagctgcaa ggctagccag agcgtgagtt ttgccggcac ttcacttatg      180

cattggtacc atcagaaacc aggccagcaa cctaggctgc tgatttatcg ggctagcaac      240

ctggaggccg gcgtgcccga ccgctttagc gggagcggct ccaagactga cttcactctg      300

accatctccc ccgtagaagc agaagatgct gcaacctact actgtcagca gtctcgcgag      360

tatccttata cattcggagg cggaactaaa ctggagatta aacgtacg                   408


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMov19 vHC CDR2

<400>  16

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  17
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMov19 vHC_CAA68252

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser 
        115         


<210>  18
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMov19 vLC_CAA68253

<400>  18

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105             


<210>  19
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chMov19 HC

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  20
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chMov19 LC

<400>  20

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  21
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chMov19 HC nucleic acid

<400>  21

Ala Ala Gly Cys Thr Thr Gly Cys Cys Ala Cys Cys Ala Thr Gly Gly 
1               5                   10                  15      


Gly Thr Thr Gly Gly Thr Cys Thr Thr Gly Thr Ala Thr Thr Ala Thr 
            20                  25                  30          


Cys Cys Thr Cys Thr Thr Thr Cys Thr Cys Gly Thr Cys Gly Cys Ala 
        35                  40                  45              


Ala Cys Cys Gly Cys Ala Ala Cys Ala Gly Gly Cys Gly Thr Cys Cys 
    50                  55                  60                  


Ala Thr Thr Cys Ala Cys Ala Ala Gly Thr Cys Cys Ala Ala Cys Thr 
65                  70                  75                  80  


Gly Cys Ala Gly Cys Ala Ala Thr Cys Cys Gly Gly Cys Gly Cys Cys 
                85                  90                  95      


Gly Ala Ala Cys Thr Cys Gly Thr Thr Ala Ala Ala Cys Cys Thr Gly 
            100                 105                 110         


Gly Ala Gly Cys Ala Thr Cys Thr Gly Thr Thr Ala Ala Ala Ala Thr 
        115                 120                 125             


Cys Thr Cys Ala Thr Gly Thr Ala Ala Ala Gly Cys Ala Thr Cys Ala 
    130                 135                 140                 


Gly Gly Ala Thr Ala Cys Thr Cys Ala Thr Thr Thr Ala Cys Thr Gly 
145                 150                 155                 160 


Gly Cys Thr Ala Thr Thr Thr Thr Ala Thr Gly Ala Ala Cys Thr Gly 
                165                 170                 175     


Gly Gly Thr Cys Ala Ala Ala Cys Ala Ala Thr Cys Ala Cys Ala Cys 
            180                 185                 190         


Gly Gly Ala Ala Ala Ala Thr Cys Ala Cys Thr Thr Gly Ala Ala Thr 
        195                 200                 205             


Gly Gly Ala Thr Cys Gly Gly Ala Cys Gly Thr Ala Thr Thr Cys Ala 
    210                 215                 220                 


Cys Cys Cys Cys Thr Ala Thr Gly Ala Thr Gly Gly Cys Gly Ala Thr 
225                 230                 235                 240 


Ala Cys Thr Thr Thr Thr Thr Ala Cys Ala Ala Cys Cys Ala Gly Ala 
                245                 250                 255     


Ala Cys Thr Thr Cys Ala Ala Ala Gly Ala Cys Ala Ala Ala Gly Cys 
            260                 265                 270         


Thr Ala Cys Ala Cys Thr Cys Ala Cys Cys Gly Thr Thr Gly Ala Cys 
        275                 280                 285             


Ala Ala Ala Thr Cys Ala Thr Cys Thr Ala Ala Cys Ala Cys Cys Gly 
    290                 295                 300                 


Cys Thr Cys Ala Cys Ala Thr Gly Gly Ala Ala Cys Thr Cys Cys Thr 
305                 310                 315                 320 


Thr Thr Cys Ala Cys Thr Cys Ala Cys Ala Thr Cys Thr Gly Ala Ala 
                325                 330                 335     


Gly Ala Cys Thr Thr Cys Gly Cys Thr Gly Thr Thr Thr Ala Thr Thr 
            340                 345                 350         


Ala Cys Thr Gly Thr Ala Cys Thr Ala Gly Ala Thr Ala Cys Gly Ala 
        355                 360                 365             


Thr Gly Gly Ala Thr Cys Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly 
    370                 375                 380                 


Gly Ala Thr Thr Ala Thr Thr Gly Gly Gly Gly Ala Cys Ala Ala Gly 
385                 390                 395                 400 


Gly Ala Ala Cys Ala Ala Cys Ala Gly Thr Cys Ala Cys Ala Gly Thr 
                405                 410                 415     


Cys Thr Cys Ala Thr Cys Thr Gly Cys Ala Thr Cys Ala Ala Cys Thr 
            420                 425                 430         


Ala Ala Gly Gly Gly Cys Cys Cys Ala 
        435                 440     


<210>  22
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chMov19 LC nucleic acid

<400>  22
gaattcgcca ccatgggttg gtcttgtatt atcctctttc tcgtcgcaac cgcaacaggc       60

gtccattcag atatcgaact cacacaatca ccagcttccc tcgcagtctc tctcggtcaa      120

cgcgcaatca tctcttgtaa agcctcccaa tcagtctcat tcgccggcac gtccctcatg      180

cattggtacc atcaaaaacc cggtcagcaa cccaaactcc ttatctatag agcaagcaac      240

ctcgaagcag gcgttcccac cagatttagc ggatcaggaa gtaaaaccga tttcacactc      300

aacattcatc cagtcgaaga agaagatgca gctacttatt attgccaaca gtctagagaa      360

tatccataca cattcggagg gggtaccaaa cttgaaatta aacgtacg                   408


<210>  23
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMov19 vHC_CAA68252

<400>  23

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser 
        115         


<210>  24
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMov19 vLC_CAA68253

<400>  24

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105             


<210>  25
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human folate receptor 1

<400>  25

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  26
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human folate receptor 1 nucleic acid sequence

<400>  26
atggctcagc ggatgacaac acagctgctg ctccttctag tgtgggtggc tgtagtaggg       60

gaggctcaga caaggattgc atgggccagg actgagcttc tcaatgtctg catgaacgcc      120

aagcaccaca aggaaaagcc aggccccgag gacaagttgc atgagcagtg tcgaccctgg      180

aggaagaatg cctgctgttc taccaacacc agccaggaag cccataagga tgtttcctac      240

ctatatagat tcaactggaa ccactgtgga gagatggcac ctgcctgcaa acggcatttc      300

atccaggaca cctgcctcta cgagtgctcc cccaacttgg ggccctggat ccagcaggtg      360

gatcagagct ggcgcaaaga gcgggtactg aacgtgcccc tgtgcaaaga ggactgtgag      420

caatggtggg aagattgtcg cacctcctac acctgcaaga gcaactggca caagggctgg      480

aactggactt cagggtttaa caagtgcgca gtgggagctg cctgccaacc tttccatttc      540

tacttcccca cacccactgt tctgtgcaat gaaatctgga ctcactccta caaggtcagc      600

aactacagcc gagggagtgg ccgctgcatc cagatgtggt tcgacccagc ccagggcaac      660

cccaatgagg aggtggcgag gttctatgct gcagccatga gtggggctgg gccctgggca      720

gcctggcctt tcctgcttag cctggcccta atgctgctgt ggctgctcag c               771


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-21 vLC CDR1

<400>  27

Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-21 vLC CDR2

<400>  28

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-21 vLC CDR3

<400>  29

Gln Gln Tyr Trp Ser Thr Pro Phe Thr 
1               5                   


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-21 vHC CDR1

<400>  30

Ser Ser Tyr Gly Met Ser 
1               5       


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-21 vHC CDR2

<400>  31

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr 
1               5                   10  


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-21 vHC CDR3

<400>  32

Asp Gly Glu Gly Gly Leu Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-21 Kabat murine CDR-H2

<400>  33

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Gly Val Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-21 Kabat human CDR-H2

<400>  34

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ser Pro Gly Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-21 vLC

<400>  35

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  36
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-21 vHC

<400>  36

Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Cys Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Gly Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Glu Gly Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muFR1-21 vLC DNA sequence

<400>  37
gacatccaga tgacacaatc ttcatcctac ttgtctgtat ctctaggagg cagagtcacc       60

attacttgca aggcaagtga ccacataaat aattggttag cctggtatca gcagaaacca      120

ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca      180

agattcagtg gcagtggatc tggaaaggat tacactctca gcatttccag tcttcagact      240

gaagatgttg ctacttatta ctgtcaacag tattggagta ctccattcac gttcggctcg      300

gggacaaagt tggaaataaa acg                                              323


<210>  38
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muFR1-21HCvarPat

<400>  38
gaagtgaagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact      120

ccagacaaga ggttggagtg tgtcgcaacc attagtagtg gtggtagtta cacctactat      180

ccagacggtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagggacggc      300

gaggggggcc tctatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  39
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-21 LC

<400>  39

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  40
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-21 HC

<400>  40

Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Cys Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Gly Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Glu Gly Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu 
                165                 170                 175     


Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         


Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser 
    210                 215                 220                 


Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala 
225                 230                 235                 240 


Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile 
                245                 250                 255     


Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
        275                 280                 285             


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
    290                 295                 300                 


Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His Gln 
305                 310                 315                 320 


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
                325                 330                 335     


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val 
            340                 345                 350         


Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser 
        355                 360                 365             


Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly 
    370                 375                 380                 


Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr 
385                 390                 395                 400 


Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr 
                405                 410                 415     


Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe 
            420                 425                 430         


Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys 
        435                 440                 445             


Thr Ile Ser Arg Ser Pro Gly Lys 
    450                 455     


<210>  41
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-21 vLC

<400>  41

Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  42
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-21 vHC

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Cys Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ser Pro Gly Phe 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Glu Gly Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  43
<211>  446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-21VH_co

<400>  43
aagcttgcca ccatgggatg gtcatgcatc attctttttc tcgtcgccac tgccacaggt       60

gtgcattccg aggtgcaact tgtagaatct ggcggggatg ttgtgaagcc tggaggtagt      120

ctcaagttgt cctgtgctgc atctgggttt accttctctt cctacggaat gagctgggtg      180

agacagactc ctggcaaggg gctggagtgc gttgccacca ttagtagtgg aggttcttac      240

acctactatt cacctggttt tcagggacgc tttacaatct cccgcgataa gtctaagaac      300

accctttacc tccagatgag tagccttaag gctgaggaca cagccatgta ttattgcgct      360

cgcgatgggg agggagggct ttacgctatg gactactggg gccagggtac cagcgtgacc      420

gtttcctctg ctagtaccaa gggccc                                           446


<210>  44
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR21VL_co

<400>  44
gaattcgcca ccatgggatg gtcatgtatc attctgttct tggtagcaac agcaactggc       60

gtccattctg acatccagat gacccaatcc tccagcagct tgtcagtatc cgttgggggc      120

cgcgttacta ttacctgtaa ggcctccgac catataaata actggcttgc atggtatcaa      180

cagaagcctg ggaaggcacc taaactgctt atctctgggg ccacaagcct ggagaccggc      240

gtgccttcca ggttctctgg aagtggatct ggcaaggact ataccttgag cattagtagc      300

cttcaacctg aggacgtcgc cacctactat tgtcagcagt attggtctac accctttacc      360

tttggacagg gcactaaatt ggagataaaa cgtacg                                396


<210>  45
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-21 LC

<400>  45

Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  46
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-21 HC

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Cys Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ser Pro Gly Phe 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Glu Gly Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  47
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-21LC

<400>  47
gacatccaga tgacccaatc ctccagcagc ttgtcagtat ccgttggggg ccgcgttact       60

attacctgta aggcctccga ccatataaat aactggcttg catggtatca acagaagcct      120

gggaaggcac ctaaactgct tatctctggg gccacaagcc tggagaccgg cgtgccttcc      180

aggttctctg gaagtggatc tggcaaggac tataccttga gcattagtag ccttcaacct      240

gaggacgtcg ccacctacta ttgtcagcag tattggtcta caccctttac ctttggacag      300

ggcactaaat tggagataaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  48
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-21HC

<400>  48
gaggtgcaac ttgtagaatc tggcggggat gttgtgaagc ctggaggtag tctcaagttg       60

tcctgtgctg catctgggtt taccttctct tcctacggaa tgagctgggt gagacagact      120

cctggcaagg ggctggagtg cgttgccacc attagtagtg gaggttctta cacctactat      180

tcacctggtt ttcagggacg ctttacaatc tcccgcgata agtctaagaa caccctttac      240

ctccagatga gtagccttaa ggctgaggac acagccatgt attattgcgc tcgcgatggg      300

gagggagggc tttacgctat ggactactgg ggccagggta ccagcgtgac cgtttcctct      360

gctagtacca agggcccatc agttttcccc ttggctccaa gttctaaatc cacaagcggt      420

ggaacagctg cactgggatg cctcgttaaa gattatttcc ctgagcctgt gacagtgagc      480

tggaatagcg gagcattgac ttcaggtgtg cacacttttc ccgctgtgtt gcagtcctcc      540

ggtctgtact cactgtccag tgtcgtaacc gtcccttcta gcagcttggg aacccagacc      600

tacatctgta acgtcaacca taaaccatcc aacacaaagg tggataagaa ggttgaacca      660

aagagctgtg ataagacaca tacatgccct ccttgtcctg caccagagct cctcggaggt      720

ccatctgtgt tcctgtttcc ccccaaaccc aaggacactc ttatgatctc tcgtactcca      780

gaggtcacct gtgttgttgt cgacgtgagc catgaagatc ccgaggttaa attcaactgg      840

tacgtggatg gagtcgaggt tcacaatgcc aagaccaagc ccagggagga gcaatataat      900

tctacatatc gggtagtgag cgttctgacc gtgctccacc aagattggct caatggaaaa      960

gagtacaagt gcaaggtgtc caacaaggct cttcccgctc ccattgagaa aactatctcc     1020

aaagccaagg ggcagccacg ggaaccccag gtgtatacat tgcccccatc tagagacgag     1080

ctgaccaaga accaggtgag tctcacttgt ctggtcaagg ggttttaccc ttctgacatt     1140

gctgtagagt gggagtctaa cggacagcca gaaaacaact acaagacaac tcccccagtg     1200

ctggacagcg acgggagctt cttcctctac tccaagttga ctgtagacaa gtctagatgg     1260

cagcaaggaa acgttttctc ctgctcagta atgcatgagg ctctgcacaa tcactatacc     1320

cagaaatcac tgtcccttag cccaggg                                         1347


<210>  49
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFolR1 DNA sequence EcoRI to Xba1

<400>  49
gaattcgcca ccatggcaca gcgcatgacc actcagctcc tgcttctgtt ggtttgggtg       60

gcagtcgtgg gagaggccca gaccaggatt gcttgggcac gcacagagct gcttaatgtt      120

tgcatgaacg caaagcacca taaagagaaa cccggtcccg aggataagtt gcacgaacag      180

tgccgccctt ggagaaagaa tgcatgctgt agcacgaaca cctctcagga ggcgcataaa      240

gacgtaagct atttgtatag atttaactgg aaccattgcg gtgaaatggc acctgcctgt      300

aaacggcact ttatccagga tacttgcttg tacgagtgta gcccgaatct cgggccctgg      360

attcagcaag ttgatcagag ttggcgcaaa gagagggtgc tgaacgttcc gctttgcaag      420

gaggactgcg agcaatggtg ggaagactgt agaaccagct acacctgtaa gtctaactgg      480

cacaaaggat ggaactggac atccgggttt aacaaatgcg ctgtcggcgc tgcctgccag      540

ccatttcatt tctactttcc aactcccact gtcctgtgta acgagatttg gacgcattca      600

tataaagtca gcaactacag ccggggctcc ggccgctgca ttcagatgtg gttcgaccct      660

gcacagggca accctaacga ggaggtcgca cgcttctacg ctgcagcaat gtctggagcc      720

ggtccttggg ctgcttggcc atttctcctt agcctcgccc tcatgcttct ctggctgttg      780

tcataatcta ga                                                          792


<210>  50
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer EcoMH1

<400>  50

Cys Thr Thr Cys Cys Gly Gly Ala Ala Thr Thr Cys Ser Ala Arg Gly 
1               5                   10                  15      


Thr Asn Met Ala Gly Cys Thr Gly Ser Ala Gly Ser Ala Gly Thr Cys 
            20                  25                  30          


<210>  51
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer EcoMH2

<400>  51

Cys Thr Thr Cys Cys Gly Gly Ala Ala Thr Thr Cys Ser Ala Arg Gly 
1               5                   10                  15      


Thr Asn Met Ala Gly Cys Thr Gly Ser Ala Gly Ser Ala Gly Thr Cys 
            20                  25                  30          


Trp Gly Gly 
        35  


<210>  52
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer BamIgG1

<400>  52

Gly Gly Ala Gly Gly Ala Thr Cys Cys Ala Thr Ala Gly Ala Cys Ala 
1               5                   10                  15      


Gly Ala Thr Gly Gly Gly Gly Gly Thr Gly Thr Cys Gly Thr Thr Thr 
            20                  25                  30          


Thr Gly Gly Cys 
        35      


<210>  53
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SacIMK

<400>  53

Gly Gly Ala Gly Cys Thr Cys Gly Ala Tyr Ala Thr Thr Gly Thr Gly 
1               5                   10                  15      


Met Thr Ser Ala Cys Met Cys Ala Arg Trp Cys Thr Met Cys Ala 
            20                  25                  30      


<210>  54
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HindKL

<400>  54

Thr Ala Thr Ala Gly Ala Gly Cys Thr Cys Ala Ala Gly Cys Thr Thr 
1               5                   10                  15      


Gly Gly Ala Thr Gly Gly Thr Gly Gly Gly Ala Ala Gly Ala Thr Gly 
            20                  25                  30          


Gly Ala Thr Ala Cys Ala Gly Thr Thr Gly Gly Thr Gly Cys 
        35                  40                  45      


<210>  55
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cd37-1LClead

<400>  55
ttttgaattc gccaccatga agtttccttc tcaacttct                              39


<210>  56
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human and chimeric Mov19 vHC CDR2 composite


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa1 = Q, H, K, or R

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa2 = R, Q, H, or N

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa3 = E, T, S, G, A, or V

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  56

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Xaa Ala Ala 
1               5                   10                  15      


Phe Xaa Ala Ala Xaa Ala Ala 
            20              


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-48vL CDR1

<400>  57

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-48vL CDR2

<400>  58

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-48vL CDR3

<400>  59

Gln His Phe Trp Ala Ser Pro Tyr Thr 
1               5                   


<210>  60
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-48vH CDR1

<400>  60

Thr Asn Tyr Trp Met Gln 
1               5       


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-48vH CDR2

<400>  61

Ala Ile Tyr Pro Gly Asn Gly Asp Ser Arg 
1               5                   10  


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-48vH CDR3

<400>  62

Arg Asp Gly Asn Tyr Ala Ala Tyr 
1               5               


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-49vL CDR1

<400>  63

Arg Ala Ser Glu Asn Ile Tyr Thr Asn Leu Ala 
1               5                   10      


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-49vL CDR2

<400>  64

Thr Ala Ser Asn Leu Ala Asp 
1               5           


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-49vL CDR3

<400>  65

Gln His Phe Trp Val Ser Pro Tyr Thr 
1               5                   


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-49vH CDR1

<400>  66

Thr Asn Tyr Trp Met Tyr 
1               5       


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-49vH CDR2

<400>  67

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr 
1               5                   10  


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-49vH CDR3

<400>  68

Arg His Asp Tyr Gly Ala Met Asp Tyr 
1               5                   


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-57vL CDR1

<400>  69

Arg Ala Ser Gln Asn Ile Asn Asn Asn Leu His 
1               5                   10      


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-57vL CDR2

<400>  70

Tyr Val Ser Gln Ser Val Ser 
1               5           


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-57vL CDR3

<400>  71

Gln Gln Ser Asn Ser Trp Pro His Tyr Thr 
1               5                   10  


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-57vH CDR1

<400>  72

Ser Ser Phe Gly Met His 
1               5       


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-57vH CDR2

<400>  73

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Ser 
1               5                   10  


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-57vH CDR3

<400>  74

Glu Ala Tyr Gly Ser Ser Met Glu Tyr 
1               5                   


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-65vL CDR1

<400>  75

Lys Ala Ser Gln Asn Val Gly Pro Asn Val Ala 
1               5                   10      


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-65vL CDR2

<400>  76

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-65vL CDR3

<400>  77

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-65vH CDR1

<400>  78

Thr Ser Tyr Thr Met His 
1               5       


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-65vH CDR2

<400>  79

Tyr Ile Asn Pro Ile Ser Gly Tyr Thr Asn 
1               5                   10  


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1-65vH CDR3

<400>  80

Gly Gly Ala Tyr Gly Arg Lys Pro Met Asp Tyr 
1               5                   10      


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-48 Kabat defined HC CDR2

<400>  81

Ala Ile Tyr Pro Gly Asn Gly Asp Ser Arg Tyr Thr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-48 Kabat defined HC CDR2

<400>  82

Ala Ile Tyr Pro Gly Asn Gly Asp Ser Arg Tyr Thr Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-49 Kabat defined HC CDR2

<400>  83

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-57 Kabat defined HC CDR2

<400>  84

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Ser Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-57 Kabat defined HC CDR2

<400>  85

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-65 Kabat defined HC CDR2

<400>  86

Tyr Ile Asn Pro Ile Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-65 Kabat defined HC CDR2

<400>  87

Tyr Ile Asn Pro Ile Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-48vL

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ala Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  89
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-48vH

<400>  89

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Ser Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Gly Asn Tyr Ala Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  90
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-49vL

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Thr Ala Ser Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Val Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  91
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-49vH

<400>  91

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Leu Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Arg His Asp Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  92
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-57vL

<400>  92

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Val Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  93
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-57vH

<400>  93

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Ser Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Leu 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Tyr Gly Ser Ser Met Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  94
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-65vL

<400>  94

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Pro Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Glu Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Ala Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  95
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-65vH

<400>  95

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ile Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Ala Tyr Gly Arg Lys Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  96
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-48vL

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ala Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  97
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-48vH

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Ser Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Gly Asn Tyr Ala Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  98
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-49vL

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Thr Ala Ser Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Val Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  99
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-49vH

<400>  99

Gln Val Gln Leu Gln Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Leu Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Val Thr Ser Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Arg His Asp Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  100
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-57vL

<400>  100

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Val Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  101
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-57vH

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Leu 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Tyr Gly Ser Ser Met Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  102
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-65vL

<400>  102

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Met Ser Thr Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Pro Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  103
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-65vH

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ile Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Ala Tyr Gly Arg Lys Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  104
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-48LC

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ala Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  105
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-48HC

<400>  105

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Ser Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Gly Asn Tyr Ala Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Glu Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Met Arg 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  106
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-49LC

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Thr Ala Ser Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Val Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  107
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-49HC

<400>  107

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Leu Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Arg His Asp Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
    210                 215                 220                 


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
                245                 250                 255     


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
            260                 265                 270         


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
        275                 280                 285             


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
    290                 295                 300                 


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
                325                 330                 335     


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
            340                 345                 350         


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
        355                 360                 365             


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
    370                 375                 380                 


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
                405                 410                 415     


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
            420                 425                 430         


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445             


<210>  108
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-57LC

<400>  108

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Val Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser 
        115                 120                 125             


Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val 
145                 150                 155                 160 


Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser 
            180                 185                 190         


Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys 
        195                 200                 205             


Ser Phe Asn Arg Asn Glu Cys 
    210                 215 


<210>  109
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-57HC

<400>  109

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Ser Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Leu 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Tyr Gly Ser Ser Met Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
    210                 215                 220                 


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
                245                 250                 255     


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
            260                 265                 270         


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
        275                 280                 285             


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
    290                 295                 300                 


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
                325                 330                 335     


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
            340                 345                 350         


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
        355                 360                 365             


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
    370                 375                 380                 


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
                405                 410                 415     


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
            420                 425                 430         


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445             


<210>  110
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-65LC

<400>  110

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Pro Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Glu Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Ala Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  111
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-65HC

<400>  111

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ile Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Ala Tyr Gly Arg Lys Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Glu Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         


Ser Met Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
    210                 215                 220                 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
    290                 295                 300                 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
305                 310                 315                 320 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
            340                 345                 350         


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
        355                 360                 365             


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
    370                 375                 380                 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser 
385                 390                 395                 400 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
                405                 410                 415     


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
            420                 425                 430         


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 


<210>  112
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-48LC

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ala Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  113
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-48HC

<400>  113

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Ser Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Gly Asn Tyr Ala Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  114
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-49LC

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Thr Ala Ser Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Val Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  115
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-49HC

<400>  115

Gln Val Gln Leu Gln Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Leu Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Val Thr Ser Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Arg His Asp Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  116
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-57LC

<400>  116

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Val Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  117
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-57HC

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Leu 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Tyr Gly Ser Ser Met Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  118
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-65LC

<400>  118

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Met Ser Thr Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Pro Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  119
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFR1-65HC

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ile Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Ala Tyr Gly Arg Lys Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  120
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-48_VL

<400>  120
gaattcgcca ccatgggatg gagttgtatc atcctgtttc ttgtggctac agccacaggg       60

gtacactccg atattcaaat gacacagtcc ccttcatccc tgtccgtcag tgtgggggaa      120

agggttacca tcacctgccg tgcatcagag aacatctatt ccaacctcgc ctggtaccaa      180

cagaaacctg gcaagtcccc taagctgttg gtctacgccg ctacaaacct cgccgatggg      240

gtgccttccc gtttcagtgg gtcagagtca ggcaccgact attctctgaa gatcaactcc      300

ctccagcctg aggatttcgg ctcctattac tgtcagcact tctgggctag tccatatact      360

ttcggccagg gaaccaaact tgaaattaaa cgtacg                                396


<210>  121
<211>  437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-48_VH

<400>  121
aagcttgcca ccatggggtg gagctgcatc atcctttttc tggtggccac tgccaccggc       60

gtgcactctc aggtccaact tgtgcagagc ggagccgagg tggccaaacc cggagctagt      120

gttaagctct catgtaaagc atctggctac acctttacta actactggat gcagtggatc      180

aagcaacggc caggccaggg cctggagtgg attggtgcta tttatcccgg aaacggggat      240

agcaggtaca ctcagaaatt tcagggaaag gctaccctta ccgccgataa gagttcttcc      300

acagcatata tgcaagtctc ctctctgacc tcagaggata gtgctgtcta ttactgcgct      360

cgccgggatg gcaactatgc agcctattgg ggtcaaggca cccttgtgac tgtatccgca      420

gcaagcacca agggccc                                                     437


<210>  122
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-49_VL

<400>  122
gaattcgcca ccatgggttg gtcatgcatt atcctgtttc tggtcgcaac agcaacaggt       60

gtgcacagtg acattcagat gacccaaagc ccctccagtc tgagcgtttc cgtgggggaa      120

cgtgtcacta tcacatgcag agcttccgag aatatttaca ctaacctcgc atggtaccag      180

cagaaacccg ggaagtctcc aaaacttctc gtatatacag ccagcaactt ggcagatggg      240

gtgcccagcc ggtttagcgg atctggttca ggcaccgact attctttgaa aattaattcc      300

ctgcagcctg aggattttgg tacctactat tgccagcatt tttgggtatc accatacact      360

tttggacagg gaacaaagct ggagatcaag cgtacg                                396


<210>  123
<211>  440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-49_VH

<400>  123
aagcttgcca ccatgggctg gtcttgtatt attctttttc ttgtggccac agccacagga       60

gtccattcac aggtacagct ccaacagtct ggcgcagttg tcgccaagcc cggcgcctct      120

gtgaagatga gttgcaaggc ctctggctac accttcacta attattggat gtactggatc      180

aaacaacgcc ccggccaggg tctggaactc attggagcca tctacccagg caactccgac      240

acaacataca atcagaagtt tcagggcaaa gcaaccctga ccgctgtaac ctcagctaat      300

accgtgtaca tggaggtaag tagcttgact agtgaagatt ccgcagtata ctattgcacc      360

aagcgccatg attacggcgc catggattac tggggccaag gtaccagtgt gaccgtgtct      420

tccgcttcca ccaagggccc                                                  440


<210>  124
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-57_VL

<400>  124
gaattcgcca ccatgggctg gtcatgcatt attttgttcc tggtcgccac cgcaaccggc       60

gttcattccg aaattgttct tactcagagc cctgcaacct tgagtgtgac acccggcgat      120

cgggtctcac tgagttgcag agcttcccag aatatcaaca ataatctgca ctggtatcag      180

cagaagcctg gccagtctcc tcgcttgctg attaagtatg tctcacagag cgtgtcaggt      240

atccctgacc gtttctccgg gtcaggttca ggcaccgact tcacactgtc catttctagc      300

gtggagcctg aggatttcgg aatgtacttt tgccagcaga gcaatagctg gcctcactac      360

acctttggcc aagggaccaa gctggagatc aagcgtacg                             399


<210>  125
<211>  440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-57_VH

<400>  125
aagcttgcca ccatgggctg gagctgtatc atcttgttcc ttgtggccac agctactggc       60

gtgcactccg aggtgcagct ggtcgaatcc ggcggaggcc tggtgcagcc tggggggagt      120

agacggctgt cctgcgctgc ctctgggttt actttctcaa gtttcggtat gcactgggtg      180

cgtcaggccc ccgggaaggg cctggaatgg gttgcttata tatcatctgg cagctccacc      240

atttcttatg ctgattccgt taagggacgc ttcaccattt ccagagacaa cagtaagaaa      300

acccttctgc tgcagatgac ctctctccgc gccgaagaca ccgcaatgta ttattgtgct      360

agagaggcct acggcagtag tatggaatac tgggggcagg ggaccctggt gaccgtgtct      420

tccgcatcta ctaagggccc                                                  440


<210>  126
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-65_VL

<400>  126
gaattcgcca ccatgggctg gtcttgcatt attctgttcc tggttgcaac agccactggc       60

gtccattccg aaatcgtgat gacccaatct cccgccacca tgtctacctc tcccggggac      120

cgggtgtctg tgacctgcaa ggcctctcag aatgttggcc caaacgtggc atggtatcaa      180

cagaaaccag ggcagtcacc cagagccctg atttactccg cttcttacag atattcagga      240

gttcccgccc ggttcacagg tagtgggtcc ggcactgact ttaccttgac catttccaac      300

atgcaatccg aggacctggc cgaatacttc tgtcagcagt acaattcata tccctataca      360

ttcggccagg ggaccaagct ggaaataaag cgtacg                                396


<210>  127
<211>  446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFR1-65_VH

<400>  127
aagcttgcca ccatgggctg gtcatgcata atcctgttcc tggtcgcaac cgctacaggt       60

gtacactccc aggtgcagtt ggtgcagagc ggggccgaag ttgctaagcc cggtgcaagt      120

gtaaaaatgt cctgcaaagc tagcgggtac acattcacat cctatactat gcattgggta      180

aaacagcgcc caggacaggg gctcgcctgg ataggctata ttaacccaat atcaggatac      240

acaaactaca atcagaaatt tcagggaaag gcaaccctga ccgccgacaa gtcctcttct      300

accgcatata tgcagctcaa ctccctgacc agtgaagata gcgcagtgta ttactgtgcc      360

tccggcggtg cttatggccg gaaacccatg gattactggg gacaaggcac ctccgtcaca      420

gtgagtagcg cctcaaccaa gggccc                                           446


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat Defined Mov19 HC CDR2 Murine

<400>  128

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat Defined Mov19 HC CDR2 Human

<400>  129

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFR1-49 Kabat defined HC CDR2

<400>  130

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Leu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


