                         SEQUENCE LISTING

<110>  Rinat Neuroscience Corporation
 
<120>  ANTAGONIST ANTI-IL-7 RECEPTOR ANTIBODIES AND METHODS

<130>  PC33990A

<140>  61/438,205
<141>  2011-01-31

<150>  61/307,670
<151>  2010-02-24

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  1

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Asn Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Val Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Cys 
            100                 105                 110     


<210>  2
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Ser Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  3
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Arg Ile Ala Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Ser 
                85                  90                  95      


Ser Ser Leu Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser 
            100                 105                 110         


<210>  4
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Ser Gly Gly Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  5
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Asn Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Val Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Met Gln Tyr Asp Ser 
                85                  90                  95      


Ser His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Cys 
            100                 105                 110     


<210>  6
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Val Phe Asn Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  7
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  7

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Asn Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Val Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Phe 
                85                  90                  95      


His His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Cys 
            100                 105                 110     


<210>  8
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Met Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  9

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Asn Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Val Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Phe 
                85                  90                  95      


His His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Cys 
            100                 105                 110     


<210>  10
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Met Gly Asn Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Asn Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Val Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Met Gln Tyr Asp Phe 
                85                  90                  95      


His His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Cys 
            100                 105                 110     


<210>  12
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Met Gly Asn Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linking peptide

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  14
caggtcaact taagggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattctgtca tgcactgggt ccgtcaagct      120

ccggggaagg gtctggagtg gctctctctt gttggttggg atggtttttt tacatactat      180

gcagactcag tgaagggccg attcaccatc tccagagaca acaccaagaa cttactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacaaggg      300

gattacatgg ggaacaactg gggccaggga accctggtca ccgtctcctc a               351


<210>  15
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  15
aattttatgc tgactcagcc ccactctgtg tcggggtctc cgggaaagac ggtgaccatc       60

tcctgcaccc gcagcagtgg cagcattgac agttcctatg tgcagtggta ccagcagcgc      120

ccgggcaatt cccccaccac tgtgatctat gaggatgacc aaagaccctc tggggtccct      180

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240

ctggtgactg aggacgaggc tgactactac tgtcagtctt atgattttca tcatctggtg      300

ttcggcggag ggaccaagct gaccgtccta tgt                                   333


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  17
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Met Gly Asn Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
            180                 185                 190         


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Thr Val Ala Pro Pro Val Ala Gly Pro Ser Val 
    210                 215                 220                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
225                 230                 235                 240 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                245                 250                 255     


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            260                 265                 270         


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
        275                 280                 285             


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    290                 295                 300                 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
305                 310                 315                 320 


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                325                 330                 335     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            340                 345                 350         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        355                 360                 365             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
    370                 375                 380                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
385                 390                 395                 400 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                405                 410                 415     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430     


<210>  18
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  18

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Asn Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Val Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Phe 
                85                  90                  95      


His His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  19
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Ser Val Met His 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  20

Asn Tyr Gly Met His 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Val Gly Trp Asp Gly Ser Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  23

Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Gly Asp Tyr Val Phe Asp Tyr 
1               5               


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Ile Ser Gly Gly Gly Met Asp Val 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Gly Asp Tyr Val Phe Asn Asn 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Gly Asp Tyr Met Gly Asp Tyr 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Gly Asp Tyr Met Gly Asn Asn 
1               5               


<210>  29
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  29

Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser Tyr Val Gln 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  30

Thr Gly Ser Ser Gly Arg Ile Ala Ser Ser Tyr Val Gln 
1               5                   10              


<210>  31
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Asp Asp Gln Arg Pro Ser 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Asp Asn Gln Arg Pro Ser 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Ser Tyr Asp Ser Ser His Leu Val 
1               5                   


<210>  34
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Ser Tyr Ala Ser Ser Ser Leu Trp Val 
1               5                   10  


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gln Tyr Asp Ser Ser His Leu Val 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Ser Tyr Asp Phe His His Leu Val 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gln Tyr Asp Phe His His Leu Val 
1               5                   


<210>  38
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  38
gaggtccagt tagtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattctgtca tgcactgggt ccgtcaagct      120

ccggggaagg gtctggagtg ggtttctctt gttggttggg atggtttttt tacatactat      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgcgaagaa ctctctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacaaggg      300

gattacatgg ggaacaactg gggccaggga accctggtca ccgtctcctc a               351


<210>  39
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  39
aattttatgc tgactcagcc ccactctgtg tcggaatctc cgggaaagac ggtgaccatc       60

tcctgcaccc gcagcagtgg cagcattgac agttcctatg tgcagtggta ccagcagcgc      120

ccgggcagct cccccaccac tgtgatctat gaggatgacc aaagaccctc tggggtccct      180

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240

ctgaaaactg aggacgaggc tgactactac tgtcagtctt atgattttca tcatctggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  40
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Met Gly Asn Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  41
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  41

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Phe 
                85                  90                  95      


His His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  42
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Met Gly Asn Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430         


<210>  43
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  43

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Phe 
                85                  90                  95      


His His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  44
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  44

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ser Ser 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Met Gln Tyr Asp Phe 
                85                  90                  95      


His His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  45
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Val Gly Trp Asp Gly Phe Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Asp Tyr Met Gly Asn Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
            180                 185                 190         


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Thr Val Ala Pro Pro Val Ala Gly Pro Ser Val 
    210                 215                 220                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
225                 230                 235                 240 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                245                 250                 255     


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            260                 265                 270         


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
        275                 280                 285             


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    290                 295                 300                 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
305                 310                 315                 320 


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                325                 330                 335     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            340                 345                 350         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        355                 360                 365             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
    370                 375                 380                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
385                 390                 395                 400 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                405                 410                 415     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430     


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Phe Thr Phe Asp Asp Ser 
1               5           


<210>  47
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Phe Thr Phe Asp Asp Ser Val Met His 
1               5                   10  


<210>  48
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Trp Asp Gly Phe Phe 
1               5       


<210>  49
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Gly Asp Tyr Met Gly Asn Asn 
1               5               


<210>  50
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Ser or Tyr

<400>  50

Xaa Xaa Val Met His 
1               5   


<210>  51
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Trp or Gly

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Phe, Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Phe, Ala or Ser

<400>  51

Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Gln or Asp

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Gly or Ile

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Tyr or Gly

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Met, Val or Gly

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be Gly or Phe

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Asn, Asp or Met

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Asn, Tyr or Asp

<400>  52

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  53
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Arg or Gly

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be Ser or Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Asp or Ala

<400>  53

Thr Xaa Ser Ser Gly Xaa Ile Xaa Ser Ser Tyr Val Gln 
1               5                   10              


<210>  54
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Asp or Asn

<400>  54

Glu Asp Xaa Gln Arg Pro Ser 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Gln or Met

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Ser or Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Phe or Ser

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be His or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be His or Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be Val or Trp

<400>  55

Xaa Xaa Tyr Xaa Xaa Xaa Xaa Leu Xaa 
1               5                   


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Phe Thr Phe Asp Asp Ser Val Met 
1               5               


<210>  57
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Trp Asp Gly Phe Phe 
1               5       


<210>  58
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be any amino acid

<400>  58

Ala Arg Xaa Xaa Xaa Xaa 
1               5       


<210>  59
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Gly Ser Ile Asp Ser Ser Tyr 
1               5               


<210>  60
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Asp Asp Gln Arg Pro Ser Gly Val 
1               5                   


<210>  61
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  61

Phe His His Leu 
1               


