                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Nishimura, Stephen
       Lou, Jianlong
       Marks, James D.
       Baron, Jody L.
 
<120>  Integrin alph-V-beta-8 Neutralizing Antibody

<130>  02307O-204720PC

<150>  US 61/305,749
<151>  2010-02-18

<150>  US 61/428,814
<151>  2010-12-30

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of engineered variable heavy region of clone 
       37E1 from Mus musculus

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Ala Ala Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Cys Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of engineered variable heavy region of clone 
       37E1b5 from Mus musculus

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Cys Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of engineered variable light region of clone 
       37E1 from Mus musculus

<400>  3

Gln Ile Val Leu Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Pro Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala 
            100                 105             


<210>  4
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of engineered variable light region of clone 
       37E1B5 from Mus musculus

<400>  4

Gln Ile Val Leu Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Pro Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala 
            100                 105             


<210>  5
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of CDR1 of engineered variable heavy region of 
       Mus musculus clone 37E1 or 37E1b5

<400>  5

Arg Tyr Trp Met Ser 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of CDR2 of engineered variable heavy region of 
       Mus musculus clone 37E1 or 37E1b5

<400>  6

Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  7
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of CDR3 of engineered variable heavy region of 
       Mus musculus clone 37E1 or 37E1b5

<400>  7

Leu Ile Thr Thr Glu Asp Tyr 
1               5           


<210>  8
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of CDR1 of engineered variable light region of 
       Mus musculus clone 37E1 or 37E1b5

<400>  8

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of CDR2 of engineered variable light region of 
       Mus musculus clone 37E1 or 37E1b5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Arg or Tyr

<400>  9

Xaa Ala Asn Arg Leu Val Asp 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide of CDR3 of engineered variable light region of 
       Mus musculus clone 37E1 or 37E1b5

<400>  10

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  11
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  11

Ile Ser Gly Gly Ser Arg Ser Glu Arg Cys Asp Ile Val Ser Asn Leu 
1               5                   10                  15      


Ile Ser Lys Gly Cys Ser Val Asp Ser Ile Glu Tyr Pro Ser Val His 
            20                  25                  30          


Val Ile Ile Pro Thr Glu Asn Glu Ile Asn Thr Gln Val Thr Pro Gly 
        35                  40                  45              


Glu Val Ser Ile Gln Leu Arg Pro Gly Ala Glu Ala Asn Phe Met Leu 
    50                  55                  60                  


Lys Val His Pro Leu Lys Lys Tyr Pro Val Asp Leu Tyr Tyr Leu Val 
65                  70                  75                  80  


Asp Val Ser Ala Ser Met His Asn Asn Ile Glu Lys Leu Asn Ser Val 
                85                  90                  95      


Gly Asn Asp Leu Ser Arg Lys Met Ala Phe Phe 
            100                 105         


<210>  12
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  12

Val Ser Gly Gly Ser Gly Ser Glu Arg Cys Asp Thr Val Ser Ser Leu 
1               5                   10                  15      


Ile Ser Lys Gly Cys Pro Val Asp Ser Ile Glu Tyr Leu Ser Val His 
            20                  25                  30          


Val Val Thr Ser Ser Glu Asn Glu Ile Asn Thr Gln Val Thr Pro Gly 
        35                  40                  45              


Glu Val Ser Val Gln Leu His Pro Gly Ala Glu Ala Asn Phe Met Leu 
    50                  55                  60                  


Lys Val Arg Pro Leu Lys Lys Tyr Pro Val Asp Leu Tyr Tyr Leu Val 
65                  70                  75                  80  


Asp Val Ser Ala Ser Met His Asn Asn Ile Glu Lys Leu Asn Ser Val 
                85                  90                  95      


Gly Asn Asp Leu Ser Lys Lys Met Ala Leu Tyr 
            100                 105         


