                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
       Parsons, Ramon
 
<120>  USE OF PTEN-LONG LEADER SEQUENCE FOR TRANSMEMBRANE DELIVERY OF 
       MOLECULES

<130>  0575/81351-A-PCT/JPW/LAD

<150>  US 61/338,377
<151>  2010-02-17

<160>  17    

<170>  PatentIn version 3.4

<210>  1
<211>  173
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  Signal Sequence of PTEN

<400>  1

Leu Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly 
            20                  25                  30          


Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg 
        35                  40                  45              


Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro 
    50                  55                  60                  


Ser Ala Ala Ala Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Ser Arg Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala 
                85                  90                  95      


Ala Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu 
            100                 105                 110         


Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln 
        115                 120                 125             


Ser Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg 
    130                 135                 140                 


Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro 
145                 150                 155                 160 


Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp 
                165                 170             


<210>  2
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly 
            20                  25                  30          


Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg 
        35                  40                  45              


Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro 
    50                  55                  60                  


Ser Ala Ala Ala Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Ser Arg Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala 
                85                  90                  95      


Ala Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu 
            100                 105                 110         


Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln 
        115                 120                 125             


Ser Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg 
    130                 135                 140                 


Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro 
145                 150                 155                 160 


Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp 
                165                 170             


<210>  3
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Arg His Gln Gln Leu Leu Pro Ser Leu Ser Ser Phe Phe Phe Ser 
1               5                   10                  15      


His Arg Leu Pro Asp 
            20      


<210>  4
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  5
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly 
            20                  25                  30          


Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg 
        35                  40                  45              


Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro 
    50                  55                  60                  


Ser Ala Ala Ala Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Ser Arg Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala 
                85                  90                  95      


Ala Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu 
            100                 105                 110         


Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln 
        115                 120                 125             


Ser Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg 
    130                 135                 140                 


Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro 
145                 150                 155                 160 


Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp Met Thr Ala 
                165                 170                 175     


Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr Gln Glu Asp 
            180                 185                 190         


Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile Ile Ala Met 
        195                 200                 205             


Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn Asn Ile Asp 
    210                 215                 220                 


Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His Tyr Lys Ile 
225                 230                 235                 240 


Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys Phe Asn Cys 
                245                 250                 255     


Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro Gln Leu Glu 
            260                 265                 270         


Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu Ser Glu Asp 
        275                 280                 285             


Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys Gly Arg Thr 
    290                 295                 300                 


Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys Phe Leu Lys 
305                 310                 315                 320 


Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr Arg Asp Lys 
                325                 330                 335     


Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr Tyr Tyr Ser 
            340                 345                 350         


Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala Leu Leu Phe 
        355                 360                 365             


His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly Gly Thr Cys 
    370                 375                 380                 


Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile Tyr Ser Ser 
385                 390                 395                 400 


Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr Phe Glu Phe 
                405                 410                 415     


Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu Phe Phe His 
            420                 425                 430         


Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His Phe Trp Val 
        435                 440                 445             


Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu Lys Val Glu 
    450                 455                 460                 


Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys Ser Ile Glu 
465                 470                 475                 480 


Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu Thr Lys Asn 
                485                 490                 495     


Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr Phe Ser Pro 
            500                 505                 510         


Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
        515                 520                 525             


Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp Val Ser Asp 
    530                 535                 540                 


Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp Ser Asp Pro 
545                 550                 555                 560 


Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile Thr Lys Val 
                565                 570                 575     


<210>  6
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly Asn Ala Gly Glu 
1               5                   10                  15      


Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro Ser Ala Ala Ala 
        35                  40                  45              


Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly Gly Gly Ser Arg 
    50                  55                  60                  


Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala Ala Ala Ala Arg 
65                  70                  75                  80  


Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu Gln Pro Ser Ser 
                85                  90                  95      


Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln Ser Gln Ala Ala 
            100                 105                 110         


Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg Ala Ile Ser Ile 
        115                 120                 125             


Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro Ser Leu Ser Ser 
    130                 135                 140                 


Phe Phe Phe Ser His Arg Leu Pro Asp Met Thr Ala Ile Ile Lys Glu 
145                 150                 155                 160 


Ile Val Ser Arg Asn Lys Arg Arg Tyr Gln Glu Asp Gly Phe Asp Leu 
                165                 170                 175     


Asp Leu Thr Tyr Ile Tyr Pro Asn Ile Ile Ala Met Gly Phe Pro Ala 
            180                 185                 190         


Glu Arg Leu Glu Gly Val Tyr Arg Asn Asn Ile Asp Asp Val Val Arg 
        195                 200                 205             


Phe Leu Asp Ser Lys His Lys Asn His Tyr Lys Ile Tyr Asn Leu Cys 
    210                 215                 220                 


Ala Glu Arg His Tyr Asp Thr Ala Lys Phe Asn Cys Arg Val Ala Gln 
225                 230                 235                 240 


Tyr Pro Phe Glu Asp His Asn Pro Pro Gln Leu Glu Leu Ile Lys Pro 
                245                 250                 255     


Phe Cys Glu Asp Leu Asp Gln Trp Leu Ser Glu Asp Asp Asn His Val 
            260                 265                 270         


Ala Ala Ile His Cys Lys Ala Gly Lys Gly Arg Thr Gly Val Met Ile 
        275                 280                 285             


Cys Ala Tyr Leu Leu His Arg Gly Lys Phe Leu Lys Ala Gln Glu Ala 
    290                 295                 300                 


Leu Asp Phe Tyr Gly Glu Val Arg Thr Arg Asp Lys Lys Gly Val Thr 
305                 310                 315                 320 


Ile Pro Ser Gln Arg Arg Tyr Val Tyr Tyr Tyr Ser Tyr Leu Leu Lys 
                325                 330                 335     


Asn His Leu Asp Tyr Arg Pro Val Ala Leu Leu Phe His Lys Met Met 
            340                 345                 350         


Phe Glu Thr Ile Pro Met Phe Ser Gly Gly Thr Cys Asn Pro Gln Phe 
        355                 360                 365             


Val Val Cys Gln Leu Lys Val Lys Ile Tyr Ser Ser Asn Ser Gly Pro 
    370                 375                 380                 


Thr Arg Arg Glu Asp Lys Phe Met Tyr Phe Glu Phe Pro Gln Pro Leu 
385                 390                 395                 400 


Pro Val Cys Gly Asp Ile Lys Val Glu Phe Phe His Lys Gln Asn Lys 
                405                 410                 415     


Met Leu Lys Lys Asp Lys Met Phe His Phe Trp Val Asn Thr Phe Phe 
            420                 425                 430         


Ile Pro Gly Pro Glu Glu Thr Ser Glu Lys Val Glu Asn Gly Ser Leu 
        435                 440                 445             


Cys Asp Gln Glu Ile Asp Ser Ile Cys Ser Ile Glu Arg Ala Asp Asn 
    450                 455                 460                 


Asp Lys Glu Tyr Leu Val Leu Thr Leu Thr Lys Asn Asp Leu Asp Lys 
465                 470                 475                 480 


Ala Asn Lys Asp Lys Ala Asn Arg Tyr Phe Ser Pro Asn Phe Lys Val 
                485                 490                 495     


Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser Asn Pro Glu Ala 
            500                 505                 510         


Ser Ser Ser Thr Ser Val Thr Pro Asp Val Ser Asp Asn Glu Pro Asp 
        515                 520                 525             


His Tyr Arg Tyr Ser Asp Thr Thr Asp Ser Asp Pro Glu Asn Glu Pro 
    530                 535                 540                 


Phe Asp Glu Asp Gln His Thr Gln Ile Thr Lys Val 
545                 550                 555     


<210>  7
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  v5-His epitope tag

<400>  7

Lys Gly Asn Ser Ala Asp Ile Gln His Ser Gly Gly Arg Ser Ser Leu 
1               5                   10                  15      


Glu Gly Pro Arg Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly 
            20                  25                  30          


Leu Asp Ser Thr Arg Thr Gly His His His His His His 
        35                  40                  45  


<210>  8
<211>  546
<212>  PRT
<213>  Artificial

<220>
<223>  PTEN-long-p53 fusion protein

<400>  8

Met Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly Asn Ala Gly Glu 
1               5                   10                  15      


Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro Ser Ala Ala Ala 
        35                  40                  45              


Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly Gly Gly Ser Arg 
    50                  55                  60                  


Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala Ala Ala Ala Arg 
65                  70                  75                  80  


Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu Gln Pro Ser Ser 
                85                  90                  95      


Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln Ser Gln Ala Ala 
            100                 105                 110         


Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg Ala Ile Ser Ile 
        115                 120                 125             


Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro Ser Leu Ser Ser 
    130                 135                 140                 


Phe Phe Phe Ser His Arg Leu Pro Asp Met Glu Glu Pro Gln Ser Asp 
145                 150                 155                 160 


Pro Ser Val Glu Pro Pro Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp 
                165                 170                 175     


Lys Leu Leu Pro Glu Asn Asn Val Leu Ser Pro Leu Pro Ser Gln Ala 
            180                 185                 190         


Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
        195                 200                 205             


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
    210                 215                 220                 


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
225                 230                 235                 240 


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
                245                 250                 255     


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
            260                 265                 270         


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
        275                 280                 285             


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
    290                 295                 300                 


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
305                 310                 315                 320 


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
                325                 330                 335     


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
            340                 345                 350         


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
        355                 360                 365             


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
    370                 375                 380                 


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
385                 390                 395                 400 


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
                405                 410                 415     


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
            420                 425                 430         


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
        435                 440                 445             


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
    450                 455                 460                 


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
465                 470                 475                 480 


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
                485                 490                 495     


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
            500                 505                 510         


Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly Gln 
        515                 520                 525             


Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp 
    530                 535                 540                 


Ser Asp 
545     


<210>  9
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Gly Arg Gly Ser Glu Pro Val Thr Ile Ser Arg Ala Gly Asn 
            20                  25                  30          


Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg Arg 
        35                  40                  45              


Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro Ser 
    50                  55                  60                  


Ala Ala Ala Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly Gly 
65                  70                  75                  80  


Gly Ser Arg Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala Ala 
                85                  90                  95      


Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu Gln 
            100                 105                 110         


Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln Ser 
        115                 120                 125             


Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg Ala 
    130                 135                 140                 


Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro Ser 
145                 150                 155                 160 


Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp 
                165                 170         


<210>  10
<211>  113
<212>  PRT
<213>  Apis mellifera

<400>  10

Met Leu Trp Glu Leu Met Gly Cys Ile Cys Phe Ser Cys Arg Arg Pro 
1               5                   10                  15      


Thr Gly Ser Arg Leu Asn Asn Lys Ile Ser Glu His Ile Ser Ala Ser 
            20                  25                  30          


Val Thr Pro Leu Met Val Cys Leu Glu Glu Gln Arg Gly Pro Glu Leu 
        35                  40                  45              


Gly Ser Cys Asp Ala Ser Ala Tyr Lys Pro Gln Pro Ser Met Ser Asn 
    50                  55                  60                  


Thr Ile Ser Asn Met Lys Met Thr Asn Arg Ile Lys Gly Met Val Ser 
65                  70                  75                  80  


Lys Arg Arg Arg Arg Phe Thr Glu Asp Gly Phe Asp Leu Asp Leu Thr 
                85                  90                  95      


Tyr Ile Arg Asp Asn Leu Ile Ala Met Gly Phe Pro Ala Glu Lys Leu 
            100                 105                 110         


Glu 
    


<210>  11
<211>  87
<212>  PRT
<213>  Caenorhabditis elegans

<400>  11

Met Val Thr Pro Pro Pro Asp Val Pro Ser Thr Ser Thr Arg Ser Met 
1               5                   10                  15      


Ala Arg Asp Leu Gln Glu Asn Pro Asn Arg Gln Pro Gly Glu Pro Arg 
            20                  25                  30          


Val Ser Glu Pro Tyr His Asn Ser Ile Val Glu Arg Ile Arg His Ile 
        35                  40                  45              


Phe Arg Thr Ala Val Ser Ser Asn Arg Cys Arg Thr Glu Tyr Gln Asn 
    50                  55                  60                  


Ile Asp Leu Asp Cys Ala Tyr Ile Thr Asp Arg Ile Ile Ala Ile Gly 
65                  70                  75                  80  


Tyr Pro Ala Thr Gly Ile Glu 
                85          


<210>  12
<211>  264
<212>  PRT
<213>  Bos taurus

<400>  12

Met Arg Asp Gly Gly Gly Arg Ser Pro Ser Pro Leu Ser Ala Pro Val 
1               5                   10                  15      


Ser Ser Arg Gly Ala Ser Phe Ser Ala Ala Ser Pro Glu Arg Glu Gly 
            20                  25                  30          


Gly Ser Arg Gly Leu Gly Arg Glu Pro Ala Glu Ala Arg Arg Arg His 
        35                  40                  45              


Leu Pro Leu Leu Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Pro Gly Arg Gly Pro Glu Ser Pro Val Thr Ile Ser Arg Ala 
65                  70                  75                  80  


Gly Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg 
                85                  90                  95      


Arg Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu 
            100                 105                 110         


Pro Ser Ala Ala Ala Ala Pro Pro Leu Ala Arg Ala Pro Glu Ala Ala 
        115                 120                 125             


Gly Gly Gly Ser Arg Ser Glu Asp Tyr Ser Ser Pro His Ser Ala Ala 
    130                 135                 140                 


Ala Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu 
145                 150                 155                 160 


Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln 
                165                 170                 175     


Ser Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg 
            180                 185                 190         


Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro 
        195                 200                 205             


Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp Met Thr Ala 
    210                 215                 220                 


Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr Gln Glu Asp 
225                 230                 235                 240 


Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile Ile Ala Asn 
                245                 250                 255     


Gly Phe Pro Ala Glu Arg Leu Glu 
            260                 


<210>  13
<211>  217
<212>  PRT
<213>  Mus musculus

<400>  13

Leu His Leu Pro Leu Leu Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ala Arg Ala 
            20                  25                  30          


Gly Asn Ala Gly Glu Leu Leu Ser Pro Leu Leu Leu Pro Pro Thr Arg 
        35                  40                  45              


Arg Arg Arg Arg Arg Met Val Gln Gly Pro Gly Pro Val Leu Ser Leu 
    50                  55                  60                  


Pro Ser Ala Ala Ala Ala Pro Pro Leu Ala Arg Ala Pro Glu Ala Ala 
65                  70                  75                  80  


Gly Gly Gly Ser Arg Cys Glu Asp Tyr Pro Ser Ser Pro His Ser Ala 
                85                  90                  95      


Ala Ser Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser 
            100                 105                 110         


Leu Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val 
        115                 120                 125             


Gln Gly Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser 
    130                 135                 140                 


Arg Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu 
145                 150                 155                 160 


Pro Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp Met Thr 
                165                 170                 175     


Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr Gln Glu 
            180                 185                 190         


Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile Ile Ala 
        195                 200                 205             


His Gly Phe Pro Ala Glu Arg Leu Glu 
    210                 215         


<210>  14
<211>  161
<212>  PRT
<213>  Pan troglodytes

<400>  14

Met Arg Asp Gly Gly Gly His Gly Pro Glu Pro Leu Ser Ala Pro Pro 
1               5                   10                  15      


Val Ala Arg Ala Pro Glu Ala Ala Gly Gly Gly Ser Arg Ser Glu Asp 
            20                  25                  30          


Tyr Ser Ser Ser Pro His Ser Ala Ala Ala Ala Ala Arg Pro Leu Ala 
        35                  40                  45              


Ala Glu Glu Lys Gln Ala Gln Ser Leu Gln Pro Ser Gly Ser Arg Arg 
    50                  55                  60                  


Ser Ser His Tyr Pro Ala Ala Val Gln Ser Gln Ala Ala Ala Glu Arg 
65                  70                  75                  80  


Gly Ala Ser Ala Thr Ala Lys Ser Arg Ala Ile Ser Ile Leu Gln Lys 
                85                  90                  95      


Lys Pro Arg His Gln Gln Leu Leu Pro Ser Leu Ser Ser Phe Phe Phe 
            100                 105                 110         


Ser His Arg Leu Pro Asp Met Thr Ala Ile Ile Lys Glu Ile Val Ser 
        115                 120                 125             


Arg Asn Lys Arg Arg Tyr Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr 
    130                 135                 140                 


Tyr Ile Tyr Pro Asn Ile Ile Ala Met Gly Phe Pro Ala Glu Arg Leu 
145                 150                 155                 160 


Glu 
    


<210>  15
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly 
            20                  25                  30          


Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg 
        35                  40                  45              


Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro 
    50                  55                  60                  


Ser Ala Ala Ala Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Ser Arg Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala 
                85                  90                  95      


Ala Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu 
            100                 105                 110         


Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln 
        115                 120                 125             


Ser Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg 
    130                 135                 140                 


Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro 
145                 150                 155                 160 


Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp Met Thr Ala 
                165                 170                 175     


Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr Gln Glu Asp 
            180                 185                 190         


Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile Ile Ala Met 
        195                 200                 205             


Gly Phe Pro Ala Glu Arg Leu Glu 
    210                 215     


<210>  16
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence

<400>  16

Leu Glu Arg Gly Gly Ala Ala Ala Ala Ala Ala Ala Pro Gly Arg Gly 
1               5                   10                  15      


Glu Ser Pro Val Thr Ile Ser Arg Ala Gly Asn Ala Gly Glu Leu Val 
            20                  25                  30          


Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg Arg Arg Arg Arg His Ile 
        35                  40                  45              


Gln Gly Pro Gly Pro Val Leu Leu Pro Ser Ala Ala Ala Ala Pro Pro 
    50                  55                  60                  


Leu Ala Arg Ala Pro Glu Ala Ala Gly Gly Gly Ser Arg Ser Glu Asp 
65                  70                  75                  80  


Tyr Ser Ser Pro His Ser Ala Ala Ala Ala Ala Arg Pro Leu Ala Ala 
                85                  90                  95      


Glu Glu Lys Gln Ala Gln Ser Leu Gln Pro Ser Ser Ser Arg Arg Ser 
            100                 105                 110         


Ser His Tyr Pro Ala Ala Val Gln Ser Gln Ala Ala Ala Glu Arg Gly 
        115                 120                 125             


Ala Ser Ala Thr Ala Lys Ser Arg Ala Ile Ser Ile Leu Gln Lys Lys 
    130                 135                 140                 


Pro Arg His Gln Gln Leu Leu Pro Ser Leu Ser Ser Phe Phe Phe Ser 
145                 150                 155                 160 


His Arg Leu Pro Asp Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg 
                165                 170                 175     


Asn Lys Arg Arg Tyr Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr 
            180                 185                 190         


Ile Tyr Pro Asn Ile Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu 
        195                 200                 205             


<210>  17
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Glu Arg Gly Gly Glu Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ser Arg Ala 
            20                  25                  30          


Gly Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg 
        35                  40                  45              


Arg Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu 
    50                  55                  60                  


Pro Ser Ala Ala Ala Ala Pro 
65                  70      


