                         SEQUENCE LISTING

<110> 	CELLECTIS
	DELENDA Christophe
	CABANIOLS Jean-Pierre
 
<120>  Improved Meganuclease Recombination System

<130>  F1546 - 37ext PCT

<160>  60   

<170>  PatentIn version 3.3

<210>  1
<211>  7179
<212>  DNA
<213>  Artificial

<220>
<223>  pIM-Universal-TK-Neo

<400>  1
gctagggata acagggtaat atcgcgccag atctgtacat tcgaagatat cttaattaag     60

cggccgctcg agtctagagg gcccgtttaa acccgctgat cagcctcgac tgtgccttct    120

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc    180

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt    240

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat    300

agcaggcatg ctggggaggc cggcctgcag gttcgaaaag ggcgaattcg cgtttaaagc    360

ttgtacatcg atgcggccgc aataaaatat ctttattttc attacatctg tgtgttggtt    420

ttttgtgtga atcgtaacta acatacgctc tccatcaaaa caaaacgaaa caaaacaaac    480

tagcaaaata ggctgtcccc agtgcaagtg caggtgccag aacatttctc tatcgaagga    540

tctgcgatcg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca gtccccgaga    600

agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc ggggtaaact    660

gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata    720

taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagc    780

tgaagcttcg aggggctcgc atctctcctt cacgcgcccg ccgccctacc tgaggccgcc    840

atccacgccg gttgagtcgc gttctgccgc ctcccgcctg tggtgcctcc tgaactgcgt    900

ccgccgtcta ggtaagttta aagctcaggt cgagaccggg cctttgtccg gcgctccctt    960

ggagcctacc tagactcagc cggctctcca cgctttgcct gaccctgctt gctcaactct   1020

acgtctttgt ttcgttttct gttctgcgcc gttacagatc caagctgtga ccggcgccta   1080

cgtaagtgat atctactaga tttatcaaaa agagtgttga cttgtgagcg ctcacaattg   1140

atacttagat tcatcgagag ggacacgtcg actactaacc ttcttctctt tcctacagct   1200

gagatcaccg gcgaaggagg gccaccatgg cttcttaccc tggacaccag catgcttctg   1260

cctttgacca ggctgccaga tccaggggcc actccaacag gagaactgcc ctaagaccca   1320

gaagacagca ggaagccact gaggtgaggc ctgagcagaa gatgccaacc ctgctgaggg   1380

tgtacattga tggacctcat ggcatgggca agaccaccac cactcaactg ctggtggcac   1440

tgggctccag ggatgacatt gtgtatgtgc ctgagccaat gacctactgg agagtgctag   1500

gagcctctga gaccattgcc aacatctaca ccacccagca caggctggac cagggagaaa   1560

tctctgctgg agatgctgct gtggtgatga cctctgccca gatcacaatg ggaatgccct   1620

atgctgtgac tgatgctgtt ctggctcctc acattggagg agaggctggc tcttctcatg   1680

cccctccacc tgccctgacc ctgatctttg acagacaccc cattgcagcc ctgctgtgct   1740

acccagcagc aaggtacctc atgggctcca tgaccccaca ggctgtgctg gcttttgtgg   1800

ccctgatccc tccaaccctc cctggcacca acattgttct gggagcactg cctgaagaca   1860

gacacattga caggctggca aagaggcaga gacctggaga gagactggac ctggccatgc   1920

tggctgcaat cagaagggtg tatggactgc tggcaaacac tgtgagatac ctccagtgtg   1980

gaggctcttg gagagaggac tggggacagc tctctggaac agcagtgccc cctcaaggag   2040

ctgagcccca gtccaatgct ggtccaagac cccacattgg ggacaccctg ttcaccctgt   2100

tcagagcccc tgagctgctg gctcccaatg gagacctgta caatgtgttt gcctgggctc   2160

tggatgttct agccaagagg ctgaggtcca tgcatgtgtt catcctggac tatgaccagt   2220

cccctgctgg atgcagagat gctctgctgc aactaacctc tggcatggtg cagacccatg   2280

tgaccacccc tggcagcatc cccaccatct gtgacctagc cagaaccttt gccagggaga   2340

tgggagaggc caactaaacc tgagctagct cgacatgata agatacattg atgagtttgg   2400

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat   2460

tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat   2520

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg   2580

gaggtttttt aaagcaagta aaacctctac aaatgtggta gatcatttaa atgttaatta   2640

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg   2700

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga   2760

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg   2820

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg   2880

gaagcgtggc gctttctcaa tgctcacgct gtaggtatct cagttcggtg taggtcgttc   2940

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg   3000

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca   3060

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt   3120

ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag   3180

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg   3240

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc   3300

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt   3360

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt   3420

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca   3480

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg   3540

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac   3600

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg   3660

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc   3720

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta   3780

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac   3840

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc   3900

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac   3960

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact   4020

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa   4080

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt   4140

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca   4200

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa   4260

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac   4320

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg   4380

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc   4440

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata   4500

ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac   4560

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag   4620

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat   4680

cagagcagat tgtactgaga gtgcaccata tggatctcga gcggccgcgg cgcgccgttg   4740

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc   4800

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa   4860

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac   4920

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca   4980

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg   5040

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt   5100

agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg   5160

gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg   5220

gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat   5280

gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctccccggg agcttgtata   5340

tccattttcg gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat   5400

ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca   5460

caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg   5520

gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg   5580

cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact   5640

gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct   5700

caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg   5760

cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt   5820

actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc   5880

gcgccagccg aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc   5940

gtgacccatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga   6000

ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc   6060

cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt   6120

atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga   6180

ttaattaaca ggactgaccg tgctacgaga tttcgattcc accgccgcct tctatgaaag   6240

gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct   6300

catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata   6360

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg   6420

tttgtccaaa ctcatcaatg tatcttatca tgtctgacgc gaattcgccc ttgcgcgcga   6480

tgtacgggcc agatatacgc gttgacattg attattgact agttattaat agtaatcaat   6540

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa   6600

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt   6660

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta   6720

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt   6780

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc   6840

tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca   6900

gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat   6960

tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa   7020

caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag   7080

cagagctctc tggctaacta gagaacccac tgcttactgg cttatcgaaa ttaatacgac   7140

tcactatagg gagacccaag ctggctagcc ttaggcgcg                          7179


<210>  2
<211>  7415
<212>  DNA
<213>  Artificial

<220>
<223>  pIM-Universal-CD:UPRT-Hygro

<400>  2
gctagggata acagggtaat atcgcgccag atctgtacat tcgaagatat cttaattaag     60

cggccgctcg agtctagagg gcccgtttaa acccgctgat cagcctcgac tgtgccttct    120

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc    180

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt    240

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat    300

agcaggcatg ctggggaggc cggcctgcag gttcgaaaag ggcgaattcg cgtttaaagc    360

ttgtacatcg atgcggccgc aataaaatat ctttattttc attacatctg tgtgttggtt    420

ttttgtgtga atcgtaacta acatacgctc tccatcaaaa caaaacgaaa caaaacaaac    480

tagcaaaata ggctgtcccc agtgcaagtg caggtgccag aacatttctc tatcgaagga    540

tctgcgatcg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca gtccccgaga    600

agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc ggggtaaact    660

gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata    720

taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagc    780

tggtgggtag ggatgaggga gggaggggca ttgtgatgta cagggctgct ctgtgagatc    840

aagggtctct taagggtggg agctggggca gggactacga gagcagccag atgggctgaa    900

agtggaactc aaggggtttc tggcacctac ctacctgctt cccgctgggg ggtggggagt    960

tggcccagag tcttaagatt ggggcagggt ggagaggtgg gctcttcctg cttcccactc   1020

atcttatagc tttctttccc cagatccgaa ttcgagatcc aaaccaagga ggaaaggata   1080

tcacagagga gaccatggtc acaggaggca tggcttcaaa gtgggaccag aagggcatgg   1140

acattgccta tgaggaggct gctctgggct acaaggaggg aggggtccca attggtggct   1200

gcctcatcaa caacaaggat ggcagtgtcc tgggcagggg ccacaacatg aggttccaga   1260

agggcagtgc caccctgcat ggggagatca gcaccctgga gaactgtggc aggctggagg   1320

gcaaggtcta caaggacacc actctgtaca ccaccctcag cccttgtgac atgtgcacag   1380

gggccatcat catgtatggc attcccaggt gtgtggtggg agagaatgtc aacttcaagt   1440

caaaaggaga gaagtacctc cagaccaggg gccatgaggt ggttgtggtg gatgatgaga   1500

ggtgcaagaa gattatgaag cagttcattg atgagagacc ccaggactgg tttgaggaca   1560

ttggggaggc ctctgagccc ttcaagaatg tgtacctcct cccccagacc aaccaactcc   1620

tgggactcta caccatcatc aggaacaaga acaccaccag gccagacttc atcttctaca   1680

gtgacaggat catcaggctc ctggtggagg agggcctcaa ccacctccct gtgcagaagc   1740

agattgtgga gactgacacc aatgagaact ttgagggagt gtctttcatg ggcaagattt   1800

gtggggtgtc cattgtgagg gctggggaga gcatggagca gggcctgagg gactgttgca   1860

ggagtgtgag gattggcaag atcctgatcc agagggatga ggagactgcc ctgcccaagc   1920

tgttctatga gaagctccct gaagacatct ctgagaggta tgtcttcctc ctggacccca   1980

tgctggcaac tggaggctct gcaatcatgg ccactgaggt gctcatcaag aggggagtca   2040

agcctgagag gatctacttc ctcaacctca tctgctcaaa ggagggcatt gagaagtacc   2100

atgctgcctt ccctgaagtg aggattgtca ctggggctct ggacaggggc ctggatgaga   2160

acaagtacct ggtccctggc ctgggagact ttggggacag atactactgt gtctaaacct   2220

gagctagctc gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca   2280

gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg tgaaatttgt   2340

gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat   2400

tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa   2460

aacctctaca aatgtggtag atccatttaa atgttaatta aaaacccgct tcggcgggtt   2520

tttttatgca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg   2580

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt   2640

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc   2700

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct   2760

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc   2820

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta   2880

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca   2940

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag   3000

tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag   3060

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt   3120

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa   3180

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg   3240

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga   3300

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta   3360

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc   3420

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg   3480

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga   3540

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt   3600

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt   3660

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc   3720

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc   3780

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca   3840

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag   3900

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg   3960

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa   4020

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa   4080

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga   4140

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga   4200

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg   4260

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt   4320

ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa   4380

aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg tgaaaacctc   4440

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga   4500

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct taactatgcg   4560

gcatcagagc agattgtact gagagtgcac catatggatc tcgataacaa aaaaccccgc   4620

cccggcgggg ttttttgtta gcggccgcgg cgcgccgttg acattgatta ttgactagtt   4680

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta   4740

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt   4800

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg   4860

tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta   4920

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga   4980

ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg   5040

tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc   5100

caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact   5160

ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt   5220

gggagaaggg cgaattctgc agatgggagc ttgtatatcc attttcggat ctgatcagca   5280

cgtgatgaaa aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt   5340

cgacagcgtc tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt   5400

cgatgtagga gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa   5460

agatcgttat gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga   5520

cattggggaa ttcagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac   5580

gttgcaagac ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat   5640

ggatgcgatc gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca   5700

aggaatcggt caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt   5760

gtatcactgg caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga   5820

tgagctgatg ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt   5880

cggctccaac aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga   5940

ggcgatgttc ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt   6000

ggcttgtatg gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc   6060

gccgcggctc cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt   6120

tgacggcaat ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc   6180

cggagccggg actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga   6240

tggctgtgta gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc   6300

aaaggaatag cacgtgctac gagatttcga ttccaccgcc gccttctatg aaaggttggg   6360

cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct   6420

ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa   6480

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc   6540

caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc   6600

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa   6660

catacgagcc ggaagcataa agtgtaaagc ctacgcgaat tcgcccttgc gcgcgatgta   6720

cgggccagat atacgcgttg acattgatta ttgactagtt attaatagta atcaattacg   6780

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc   6840

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc   6900

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact   6960

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat   7020

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact   7080

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac   7140

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac   7200

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac   7260

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga   7320

gctctctggc taactagaga acccactgct tactggctta tcgaaattaa tacgactcac   7380

tatagggaga cccaagctgg ctagccttag gcgcg                              7415


<210>  3
<211>  795
<212>  DNA
<213>  Artificial

<220>
<223>  nptl gene

<400>  3
atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc     60

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca    120

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg    180

caggacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg    240

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag    300

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg    360

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc    420

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa    480

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac    540

ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat    600

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac    660

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc    720

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt    780

gacgagttct tctga                                                     795


<210>  4
<211>  1038
<212>  DNA
<213>  Artificial

<220>
<223>  hph gene

<400>  4
atgaagaagc ccgaactcac cgctaccagc gttgaaaaat ttctcatcga gaagttcgac     60

agtgtgagcg acctgatgca gttgtcggag ggcgaagaga gccgagcctt cagcttcgat    120

gtcggcggac gcggctatgt actgcgggtg aatagctgcg ctgatggctt ctacaaagac    180

cgctacgtgt accgccactt cgccagcgct gcactaccca tccccgaagt gttggacatc    240

ggcgagttca gcgagagcct gacatactgc atcagtagac gcgcccaagg cgttactctc    300

caagacctcc ccgaaacaga gctgcctgct gtgttacagc ctgtcgccga agctatggat    360

gctattgccg ccgccgacct cagtcaaacc agcggcttcg gcccattcgg gccccaaggc    420

atcggccagt acacaacctg gcgggatttc atttgcgcca ttgctgatcc ccatgtctac    480

cactggcaga ccgtgatgga cgacaccgtg tccgccagcg tagctcaagc cctggacgaa    540

ctgatgctgt gggccgaaga ctgtcccgag gtgcgccacc tcgtccatgc cgacttcggc    600

agcaacaacg tcctgaccga caacggccgc atcaccgccg taatcgactg gtccgaagct    660

atgttcgggg acagtcagta cgaggtggcc aacatcttct tctggcggcc ctggctggct    720

tgcatggagc agcagactcg ctacttcgag cgccggcatc ccgagctggc cggcagccct    780

cgtctgcgag cctacatgct gcgcatcggc ctggatcagc tctaccagag cctcgtggac    840

ggcaacttcg acgatgctgc ctgggctcaa ggccgctgcg atgccatcgt ccgcagcggg    900

gccggcaccg tcggtcgcac acaaatcgct cgccggagcg cagccgtatg gaccgacggc    960

tgcgtcgagg tgctggccga cagcggcaac cgccggccca gtacacgacc gcgcgctaag   1020

gaggtaggtc gagtttaa                                                 1038


<210>  5
<211>  600
<212>  DNA
<213>  Artificial

<220>
<223>  pac

<400>  5
atgaccgagt acaagcctac cgtgcgcctg gccactcgcg atgatgtgcc ccgcgccgtc     60

cgcactctgg ccgccgcttt cgccgactac cccgctaccc ggcacaccgt ggaccccgac    120

cggcacatcg agcgtgtgac agagttgcag gagctgttcc tgacccgcgt cgggctggac    180

atcggcaagg tgtgggtagc cgacgacggc gcggccgtgg ccgtgtggac tacccccgag    240

agcgttgagg ccggcgccgt gttcgccgag atcggccccc gaatggccga gctgagcggc    300

agccgcctgg ccgcccagca gcaaatggag ggcctgcttg ccccccatcg tcccaaggag    360

cctgcctggt ttctggccac tgtaggagtg agccccgacc accagggcaa gggcttgggc    420

agcgccgtcg tgttgcccgg cgtagaggcc gccgaacgcg ccggtgtgcc cgcctttctc    480

gaaacaagcg caccaagaaa ccttccattc tacgagcgcc tgggcttcac cgtgaccgcc    540

gatgtcgagg tgcccgaggg acctaggacc tggtgtatga cacgaaaacc tggcgcctaa    600


<210>  6
<211>  399
<212>  DNA
<213>  Artificial

<220>
<223>  bsr gene

<400>  6
atggccaagc ctttgtctca agaagaatcc accctcattg aaagagcaac ggctacaatc     60

aacagcatcc ccatctctga agactacagc gtcgccagcg cagctctctc tagcgacggc    120

cgcatcttca ctggtgtcaa tgtatatcat tttactgggg gaccttgtgc agaactcgtg    180

gtgctgggca ctgctgctgc tgcggcagct ggcaacctga cttgtatcgt cgcgatcgga    240

aatgagaaca ggggcatctt gagcccctgc ggacggtgcc gacaggtgct tctcgatctg    300

catcctggga tcaaagccat agtgaaggac agtgatggac agccgacggc agttgggatt    360

cgtgaattgc tgccctctgg ttatgtgtgg gagggctaa                           399


<210>  7
<211>  375
<212>  DNA
<213>  Artificial

<220>
<223>  sh ble gene

<400>  7
atggccaagt tgaccagtgc cgttccggtg ctcaccgcgc gcgacgtcgc cggagcggtc     60

gagttctgga ccgaccggct cgggttctcc cgggacttcg tggaggacga cttcgccggt    120

gtggtccggg acgacgtgac cctgttcatc agcgcggtcc aggaccaggt ggtgccggac    180

aacaccctgg cctgggtgtg ggtgcgcggc ctggacgagc tgtacgccga gtggtcggag    240

gtcgtgtcca cgaacttccg ggacgcctcc gggccggcca tgaccgagat cggcgagcag    300

ccgtgggggc gggagttcgc cctgcgcgac ccggccggca actgcgtgca cttcgtggcc    360

gaggagcagg actga                                                     375


<210>  8
<211>  655
<212>  DNA
<213>  Artificial

<220>
<223>  HSV TK DelCpG gene

<400>  8
cgatgtacgg gccagatata cgcgttgaca ttgattattg actagttatt aatagtaatc     60

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt    120

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta    180

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg    240

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga    300

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt    360

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg    420

gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc    480

cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg    540

taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat    600

aagcagagct ctctggctaa ctagagaacc cactgcttac tggcttatcg aaatt         655


<210>  9
<211>  344
<212>  DNA
<213>  Artificial

<220>
<223>  CD:UPRT DelCpG

<400>  9
ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt     60

atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca    120

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta    180

actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga    240

ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag    300

tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agct                     344


<210>  10
<211>  1131
<212>  DNA
<213>  Artificial

<220>
<223>  cytomegalovirus immediate-early promoter

<400>  10
atggcttctt accctggaca ccagcatgct tctgcctttg accaggctgc cagatccagg     60

ggccactcca acaggagaac tgccctaaga cccagaagac agcaggaagc cactgaggtg    120

aggcctgagc agaagatgcc aaccctgctg agggtgtaca ttgatggacc tcatggcatg    180

ggcaagacca ccaccactca actgctggtg gcactgggct ccagggatga cattgtgtat    240

gtgcctgagc caatgaccta ctggagagtg ctaggagcct ctgagaccat tgccaacatc    300

tacaccaccc agcacaggct ggaccaggga gaaatctctg ctggagatgc tgctgtggtg    360

atgacctctg cccagatcac aatgggaatg ccctatgctg tgactgatgc tgttctggct    420

cctcacattg gaggagaggc tggctcttct catgcccctc cacctgccct gaccctgatc    480

tttgacagac accccattgc agccctgctg tgctacccag cagcaaggta cctcatgggc    540

tccatgaccc cacaggctgt gctggctttt gtggccctga tccctccaac cctccctggc    600

accaacattg ttctgggagc actgcctgaa gacagacaca ttgacaggct ggcaaagagg    660

cagagacctg gagagagact ggacctggcc atgctggctg caatcagaag ggtgtatgga    720

ctgctggcaa acactgtgag atacctccag tgtggaggct cttggagaga ggactgggga    780

cagctctctg gaacagcagt gccccctcaa ggagctgagc cccagtccaa tgctggtcca    840

agaccccaca ttggggacac cctgttcacc ctgttcagag cccctgagct gctggctccc    900

aatggagacc tgtacaatgt gtttgcctgg gctctggatg ttctagccaa gaggctgagg    960

tccatgcatg tgttcatcct ggactatgac cagtcccctg ctggatgcag agatgctctg   1020

ctgcaactaa cctctggcat ggtgcagacc catgtgacca cccctggcag catccccacc   1080

atctgtgacc tagccagaac ctttgccagg gagatgggag aggccaacta a            1131


<210>  11
<211>  1122
<212>  DNA
<213>  Artificial

<220>
<223>  simian virus 40 promoter

<400>  11
atggtcacag gaggcatggc ttcaaagtgg gaccagaagg gcatggacat tgcctatgag     60

gaggctgctc tgggctacaa ggagggaggg gtcccaattg gtggctgcct catcaacaac    120

aaggatggca gtgtcctggg caggggccac aacatgaggt tccagaaggg cagtgccacc    180

ctgcatgggg agatcagcac cctggagaac tgtggcaggc tggagggcaa ggtctacaag    240

gacaccactc tgtacaccac cctcagccct tgtgacatgt gcacaggggc catcatcatg    300

tatggcattc ccaggtgtgt ggtgggagag aatgtcaact tcaagtcaaa aggagagaag    360

tacctccaga ccaggggcca tgaggtggtt gtggtggatg atgagaggtg caagaagatt    420

atgaagcagt tcattgatga gagaccccag gactggtttg aggacattgg ggaggcctct    480

gagcccttca agaatgtgta cctcctcccc cagaccaacc aactcctggg actctacacc    540

atcatcagga acaagaacac caccaggcca gacttcatct tctacagtga caggatcatc    600

aggctcctgg tggaggaggg cctcaaccac ctccctgtgc agaagcagat tgtggagact    660

gacaccaatg agaactttga gggagtgtct ttcatgggca agatttgtgg ggtgtccatt    720

gtgagggctg gggagagcat ggagcagggc ctgagggact gttgcaggag tgtgaggatt    780

ggcaagatcc tgatccagag ggatgaggag actgccctgc ccaagctgtt ctatgagaag    840

ctccctgaag acatctctga gaggtatgtc ttcctcctgg accccatgct ggcaactgga    900

ggctctgcaa tcatggccac tgaggtgctc atcaagaggg gagtcaagcc tgagaggatc    960

tacttcctca acctcatctg ctcaaaggag ggcattgaga agtaccatgc tgccttccct   1020

gaagtgagga ttgtcactgg ggctctggac aggggcctgg atgagaacaa gtacctggtc   1080

cctggcctgg gagactttgg ggacagatac tactgtgtct aa                      1122


<210>  12
<211>  883
<212>  DNA
<213>  Artificial

<220>
<223>  human elongation factor 1  promoter

<400>  12
gatctaaagc taactgtagg actgagtcta ttctaaactg aaagcctgga catctggagt     60

accaggggga gatgacgtgt tacgggcttc cataaaagca gctggctttg aatggaagga    120

gccaagaggc cagcacagga gcggattcgt cgctttcacg gccatcgagc cgaacctctc    180

gcaagtccgt gagccgttaa ggaggccccc agtcccgacc cttcgcccca agcccctcgg    240

ggtccccggg cctggtactc cttgccacac gggaggggcg cggaagccgg ggcggaggag    300

gagccaaccc cgggctgggc tgagacccgc agaggaagac gctctaggga tttgtcccgg    360

actagcgaga tggcaaggct gaggacggga ggctgattga gaggcgaagg tacaccctaa    420

tctcaataca acctttggag ctaagccagc aatggtagag ggaagattct gcacgtccct    480

tccaggcggc ctccccgtca ccaccccccc caacccgccc cgaccggagc tgagagtaat    540

tcatacaaaa ggactcgccc ctgccttggg gaatcccagg gaccgtcgtt aaactcccac    600

taacgtagaa cccagagatc gctgcgttcc cgccccctca cccgcccgct ctcgtcatca    660

ctgaggtgga gaagagcatg cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc    720

gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag    780

gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg    840

tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gtt                      883


<210>  13
<211>  301
<212>  DNA
<213>  Artificial

<220>
<223>  human phosphoglycerate kinase promoter

<400>  13
aattccacgg ggttggggtt gcgccttttc caaggcagcc ctgggtttgc gcagggacgc     60

ggctgctctg ggcgtggttc cgggaaacgc agcggcgccg accctgggtc tcgcacattc    120

ttcacgtccg ttcgcagcgt cacccggatc ttcgccgcta cccttgtggg ccccccggcg    180

acgcttcctg ctccgcccct aagtcgggaa ggttccttgc ggttcgcggc gtgccggacg    240

tgacaaacgg aagccgcacg tctcactagt accctcgcag acggacagcg ccagggagca    300

a                                                                    301


<210>  14
<211>  507
<212>  DNA
<213>  Artificial

<220>
<223>  murine phosphoglycerate kinase promoter

<400>  14
ctaccgggta ggggaggcgc ttttcccaag gcagtctgga gcatgcgctt tagcagcccc     60

gctgggcact tggcgctaca caagtggcct ctggcctcgc acacattcca catccaccgg    120

taggcgccaa ccggctccgt tctttggtgg ccccttcgcg ccaccttcta ctcctcccct    180

agtcaggaag ttcccccccg ccccgcagct cgcgtcgtgc aggacgtgac aaatggaagt    240

agcacgtctc actagtctcg tgcagatgga cagcaccgct gagcaatgga agcgggtagg    300

cctttggggc agcggccaat agcagctttg ctccttcgct ttctgggctc agaggctggg    360

aaggggtggg tccgggggcg ggctcagggg cgggctcagg ggcggggcgg gcgcccgaag    420

gtcctccgga ggcccggcat tctgcacgct tcaaaagcgc acgtctgccg cgctgttctc    480

ctcttcctca tctccgggcc tttcgac                                        507


<210>  15
<211>  1212
<212>  DNA
<213>  Artificial

<220>
<223>  human polyubiquitin promoter

<400>  15
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg     60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag    120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag    180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg    240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat    300

gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt    360

cgcggttctt gtttgtggat cgctgtgatc gtcacttggt gagtagcggg ctgctgggct    420

ggccggggct ttcgtggccg ccgggccgct cggtgggacg gaagcgtgtg gagagaccgc    480

caagggctgt agtctgggtc cgcgagcaag gttgccctga actgggggtt ggggggagcg    540

cagcaaaatg gcggctgttc ccgagtcttg aatggaagac gcttgtgagg cgggctgtga    600

ggtcgttgaa acaaggtggg gggcatggtg ggcggcaaga acccaaggtc ttgaggcctt    660

cgctaatgcg ggaaagctct tattcgggtg agatgggctg gggcaccatc tggggaccct    720

gacgtgaagt ttgtcactga ctggagaact cggtttgtcg tctgttgcgg gggcggcagt    780

tatggcggtg ccgttgggca gtgcacccgt acctttggga gcgcgcgccc tcgtcgtgtc    840

gtgacgtcac ccgttctgtt ggcttataat gcagggtggg gccacctgcc ggtaggtgtg    900

cggtaggctt ttctccgtcg caggacgcag ggttcgggcc tagggtaggc tctcctgaat    960

cgacaggcgc cggacctctg gtgaggggag ggataagtga ggcgtcagtt tctttggtcg   1020

gttttatgta cctatcttct taagtagctg aagctccggt tttgaactat gcgctcgggg   1080

ttggcgagtg tgttttgtga agttttttag gcaccttttg aaatgtaatc atttgggtca   1140

atatgtaatt ttcagtgtta gactagtaaa ttgtccgcta aattctggcc gtttttggct   1200

tttttgttag ac                                                       1212


<210>  16
<211>  753
<212>  DNA
<213>  Artificial

<220>
<223>  thymidine kinase promoter from human herpes simplex virus

<400>  16
aaatgagtct tcggacctcg cgggggccgc ttaagcggtg gttagggttt gtctgacgcg     60

gggggagggg gaaggaacga aacactctca ttcggaggcg gctcggggtt tggtcttggt    120

ggccacgggc acgcagaaga gcgccgcgat cctcttaagc acccccccgc cctccgtgga    180

ggcgggggtt tggtcggcgg gtggtaactg gcgggccgct gactcgggcg ggtcgcgcgc    240

cccagagtgt gaccttttcg gtctgctcgc agacccccgg gcggcgccgc cgcggcggcg    300

acgggctcgc tgggtcctag gctccatggg gaccgtatac gtggacaggc tctggagcat    360

ccgcacgact gcggtgatat taccggagac cttctgcggg acgagccggg tcacgcggct    420

gacgcggagc gtccgttggg cgacaaacac caggacgggg cacaggtaca ctatcttgtc    480

acccggaggc gcgagggact gcaggagctt cagggagtgg cgcagctgct tcatccccgt    540

ggcccgttgc tcgcgtttgc tggcggtgtc cccggaagaa atatatttgc atgtctttag    600

ttctatgatg acacaaaccc cgcccagcgt cttgtcattg gcgaattcga acacgcagat    660

gcagtcgggg cggcgcggtc ccaggtccac ttcgcatatt aaggtgacgc gtgtggcctc    720

gaacaccgag cgaccctgca gcgacccgct taa                                 753


<210>  17
<211>  746
<212>  DNA
<213>  Artificial

<220>
<223>  human growth arrest specific 5 promoter

<400>  17
ggcaagggag ttgcgggcgc acaggtaagg cgcgggaccg ggaagggggc ggcgccccgg     60

gatcggtcta gggcggcgga ggctgccggg gcgggggtgt gtctgggtgt ggccccggcg    120

cgcgcggggt cctgagggag gggctcgcca agggggcggg cccgcgagct cgacagcccc    180

gagccaaagg ggcggaaggt cgccgagtgc tgggagggga ggtggggcag cgactgagcg    240

ccgcaggagc tggctgcaac ccagacgcgg cccgggagcg tcgggtatga gctaacgggg    300

cgggggtgcg gggaacgagc ccagtcaagg agcagcacct acctccgggg gtggaaatgg    360

gccggaatgg gccggaacac cgtcccggaa gtgaaacccc ccgccccctc ctccgcagcg    420

agcgacgtgc cggaaggaaa tcagtcaccc tccccccgcc cctcccccag cactttcctt    480

gcaggagccc cctcccctca gcctgtactc ctcagggagg cggagggcgg gcctatcgtg    540

cccgcggcaa ctccgccctc cgggctctcg ggggcgtggc cagagggaaa gttttgtggg    600

cctgaagaag gtggggcttg aggaggagtc tgagggcgtg tgaggggcgg ggtttaagtg    660

gacgcagcaa gcagctttgc gtcttgacgt cacgaagacc ttatatactc gactcagccg    720

ccatctcagc ctttcggagc tgtgcg                                         746


<210>  18
<211>  316
<212>  DNA
<213>  Artificial

<220>
<223>  tetracycline-responsive element

<400>  18
cgagtttact ccctatcagt gatagagaac gtatgtcgag tttactccct atcagtgata     60

gagaacgatg tcgagtttac tccctatcag tgatagagaa cgtatgtcga gtttactccc    120

tatcagtgat agagaacgta tgtcgagttt actccctatc agtgatagag aacgtatgtc    180

gagtttatcc ctatcagtga tagagaacgt atgtcgagtt tactccctat cagtgataga    240

gaacgtatgt cgaggtaggc gtgtacggtg ggaggcctat ataagcagag ctcgtttagt    300

gaaccgtcag atcgcc                                                    316


<210>  19
<211>  596
<212>  DNA
<213>  Artificial

<220>
<223>  internal ribosomal entry site (IRES) sequence from encephalopathy
       myocarditis virus

<400>  19
aattccgccc ctctcccccc cccccctctc cctccccccc ccctaacgtt actggccgaa     60

gccgcttgga ataaggccgg tgtgcgtttg tctatatgtg attttccacc atattgccgt    120

cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg    180

gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc    240

ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc    300

ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa    360

aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc    420

tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg    480

gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac    540

gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataa        596


<210>  20
<211>  469
<212>  DNA
<213>  Artificial

<220>
<223>  IRES sequence from foot and mouth disease virus

<400>  20
agcaggtttc cccaatgaca caaaacgtgc aacttgaaac tccgcctggt ctttccaggt     60

ctagaggggt aacactttgt actgcgtttg gctccacgct cgatccactg gcgagtgtta    120

gtaacagcac tgttgcttcg tagcggagca tgacggccgt gggaactcct ccttggtaac    180

aaggacccac ggggccaaaa gccacgccca cacgggcccg tcatgtgtgc aaccccagca    240

cggcgacttt actgcgaaac ccactttaaa gtgacattga aactggtacc cacacactgg    300

tgacaggcta aggatgccct tcaggtaccc cgaggtaaca cgcgacactc gggatctgag    360

aaggggactg gggcttctat aaaagcgctc ggtttaaaaa gcttctatgc ctgaataggt    420

gaccggaggt cggcaccttt cctttgcaat tactgaccct atgaataca                469


<210>  21
<211>  131
<212>  DNA
<213>  Artificial

<220>
<223>  SV40 polyadenylation signal

<400>  21
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca     60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct    120

tatcatgtct g                                                         131


<210>  22
<211>  215
<212>  DNA
<213>  Artificial

<220>
<223>  bovine growth hormone polyadenylation signal

<400>  22
gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     60

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg    120

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg    180

gaggattggg aagacaatag caggcatgct gggga                               215


<210>  23
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  FLAG tag

<400>  23

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  24
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  FLASH/REASH tag

<400>  24

Cys Cys Pro Gly Cys Cys 
1               5       


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  IQ tag

<400>  25

Ile Gln Ser Pro His Phe Phe 
1               5           


<210>  26
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  histidine tag

<400>  26

His His His His His His 
1               5       


<210>  27
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  STREP tag

<400>  27

Trp Ser His Pro Glu Phe Glu Lys 
1               5               


<210>  28
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  streptavidin binding protein

<400>  28

Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro Ser Gly Gly Cys Lys Leu Gly 
        35                  40                  45  


<210>  29
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  calmodulin binding protein

<400>  29

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  30
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  haemagglutinin tag

<400>  30

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  31
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  c-myc tag

<400>  31

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  32
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  V5 tag

<400>  32

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  33
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  nuclear localization signal from nucleoplasmin

<400>  33

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  34
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  NLS from SV40

<400>  34

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  35
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  NLS consensus


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Lys Lys Arg Xaa Lys Arg 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  thrombin cleavage site

<400>  36

Leu Val Pro Arg Gly Ser 
1               5       


<210>  37
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  P2A cleavage site

<400>  37
gccacgaagc aagcaggatg ttgaagaaaa ccccgggcct                           40


<210>  38
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  T2A cleavage site

<400>  38
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct           54


<210>  39
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  E2A cleavage site

<400>  39
cagtgtacta attatgctct cttgaaattg gctggagatg ttgagagcaa cccaggtccc     60


<210>  40
<211>  1668
<212>  DNA
<213>  Artificial

<220>
<223>  firefly luciferase gene

<400>  40
gtgattgcag aattcatgga agatgccaaa aacattaaga agggcccagc gccattctac     60

ccactcgaag acgggaccgc cggcgagcag ctgcacaaag ccatgaagcg ctacgccctg    120

gtgcccggca ccatcgcctt taccgacgca catatcgagg tggacattac ctacgccgag    180

tacttcgaga tgagcgttcg gctggcagaa gctatgaagc gctatgggct gaatacaaac    240

catcggatcg tggtgtgcag cgagaatagc ttgcagttct tcatgcccgt gttgggtgcc    300

ctgttcatcg gtgtggctgt ggccccagct aacgacatct acaacgagcg cgagctgctg    360

aacagcatgg gcatcagcca gcccaccgtc gtattcgtga gcaagaaagg gctgcaaaag    420

atcctcaacg tgcaaaagaa gctaccgatc atacaaaaga tcatcatcat ggatagcaag    480

accgactacc agggcttcca aagcatgtac accttcgtga cttcccattt gccacccggc    540

ttcaacgagt acgacttcgt gcccgagagc ttcgaccggg acaaaaccat cgccctgatc    600

atgaacagta gtggcagtac cggattgccc aagggcgtag ccctaccgca ccgcaccgct    660

tgtgtccgat tcagtcatgc ccgcgacccc atcttcggca accagatcat ccccgacacc    720

gctatcctca gcgtggtgcc atttcaccac ggcttcggca tgttcaccac gctgggctac    780

ttgatctgcg gctttcgggt cgtgctcatg taccgcttcg aggaggagct attcttgcgc    840

agcttgcaag actataagat tcaatctgcc ctgctggtgc ccacactatt tagcttcttc    900

gctaagagca ctctcatcga caagtacgac ctaagcaact tgcacgagat cgccagcggc    960

ggggcgccgc tcagcaagga ggtaggtgag gccgtggcca aacgcttcca cctaccaggc   1020

atccgccagg gctacggcct gacagaaaca accagcgcca ttctgatcac ccccgaaggg   1080

gacgacaagc ctggcgcagt aggcaaggtg gtgcccttct tcgaggctaa ggtggtggac   1140

ttggacaccg gtaagacact gggtgtgaac cagcgcggcg agctgtgcgt ccgtggcccc   1200

atgatcatga gcggctacgt taacaacccc gaggctacaa acgctctcat cgacaaggac   1260

ggctggctgc acagcggcga catcgcctac tgggacgagg acgagcactt cttcatcgtg   1320

gaccggctga agagcctgat caaatacaag ggctaccagg tagccccagc cgaactggag   1380

agcatcctgc tgcaacaccc caacatcttc gacgccgggg tcgccggcct gcccgacgac   1440

gatgccggcg agctgcccgc cgcagtcgtc gtgctggaac acggtaaaac catgaccgag   1500

aaggagatcg tggactatgt ggccagccag gttacaaccg ccaagaagct gcgcggtggt   1560

gttgtgttcg tggacgaggt gcctaaagga ctgaccggca agttggacgc ccgcaagatc   1620

cgcgagattc tcattaaggc caagaagggc ggcaagatcg ccgtgtaa                1668


<210>  41
<211>  936
<212>  DNA
<213>  Artificial

<220>
<223>  renilla luciferase gene

<400>  41
atgacttcga aagtttatga tccagaacaa aggaaacgga tgataactgg tccgcagtgg     60

tgggccagat gtaaacaaat gaatgttctt gattcattta ttaattatta tgattcagaa    120

aaacatgcag aaaatgctgt tattttttta catggtaacg cggcctcttc ttatttatgg    180

cgacatgttg tgccacatat tgagccagta gcgcggtgta ttataccaga ccttattggt    240

atgggcaaat caggcaaatc tggtaatggt tcttataggt tacttgatca ttacaaatat    300

cttactgcat ggtttgaact tcttaattta ccaaagaaga tcatttttgt cggccatgat    360

tggggtgctt gtttggcatt tcattatagc tatgagcatc aagataagat caaagcaata    420

gttcacgctg aaagtgtagt agatgtgatt gaatcatggg atgaatggcc tgatattgaa    480

gaagatattg cgttgatcaa atctgaagaa ggagaaaaaa tggttttgga gaataacttc    540

ttcgtggaaa ccatgttgcc atcaaaaatc atgagaaagt tagaaccaga agaatttgca    600

gcatatcttg aaccattcaa agagaaaggt gaagttcgtc gtccaacatt atcatggcct    660

cgtgaaatcc cgttagtaaa aggtggtaaa cctgacgttg tacaaattgt taggaattat    720

aatgcttatc tacgtgcaag tgatgattta ccaaaaatgt ttattgaatc ggacccagga    780

ttcttttcca atgctattgt tgaaggtgcc aagaagtttc ctaatactga atttgtcaaa    840

gtaaaaggtc ttcatttttc gcaagaagat gcacctgatg aaatgggaaa atatatcaaa    900

tcgttcgttg agcgagttct caaaaatgaa caataa                              936


<210>  42
<211>  3075
<212>  DNA
<213>  Artificial

<220>
<223>  beta - galactosidase gene

<400>  42
atgatagatc ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt     60

aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc    120

gatcgccctt cccaacagtt gcgcagcctg aatggcgaat ggcgctttgc ctggtttccg    180

gtaccagaag cggtgccgga aagctggctg gagtgcgatc ttcctgaggc cgatactgtc    240

gtcgtcccct caaactggca gatgcacggt tacgatgcgc ccatctacac caacgtaacc    300

tatcccatta cggtcaatcc gccgtttgtt cccacggaga atccgacggg ttgttactcg    360

ctcacattta atgttgatga aagctggcta caggaaggcc agacgcgaat tatttttgat    420

ggcgttaact cggcgtttca tctgtggtgc aacgggcgct gggtcggtta cggccaggac    480

agtcgtttgc cgtctgaatt tgacctgagc gcatttttac gcgccggaga aaaccgcctc    540

gcggtgatgg tgctgcgttg gagtgacggc agttatctgg aagatcagga tatgtggcgg    600

atgagcggca ttttccgtga cgtctcgttg ctgcataaac cgactacaca aatcagcgat    660

ttccatgttg ccactcgctt taatgatgat ttcagccgcg ctgtactgga ggctgaagtt    720

cagatgtgcg gcgagttgcg tgactaccta cgggtaacag tttctttatg gcagggtgaa    780

acgcaggtcg ccagcggcac cgcgcctttc ggcggtgaaa ttatcgatga gcgtggtggt    840

tatgccgatc gcgtcacact acgtctgaac gtcgaaaacc cgaaactgtg gagcgccgaa    900

atcccgaatc tctatcgtgc ggtggttgaa ctgcacaccg ccgacggcac gctgattgaa    960

gcagaagcct gcgatgtcgg tttccgcgag gtgcggattg aaaatggtct gctgctgctg   1020

aacggcaagc cgttgctgat tcgaggcgtt aaccgtcacg agcatcatcc tctgcatggt   1080

caggtcatgg atgagcagac gatggtgcag gatatcctgc tgatgaagca gaacaacttt   1140

aacgccgtgc gctgttcgca ttatccgaac catccgctgt ggtacacgct gtgcgaccgc   1200

tacggcctgt atgtggtgga tgaagccaat attgaaaccc acggcatggt gccaatgaat   1260

cgtctgaccg atgatccgcg ctggctaccg gcgatgagcg aacgcgtaac gcgaatggtg   1320

cagcgcgatc gtaatcaccc gagtgtgatc atctggtcgc tggggaatga atcaggccac   1380

ggcgctaatc acgacgcgct gtatcgctgg atcaaatctg tcgatccttc ccgcccggtg   1440

cagtatgaag gcggcggagc cgacaccacg gccaccgata ttatttgccc gatgtacgcg   1500

cgcgtggatg aagaccagcc cttcccggct gtgccgaaat ggtccatcaa aaaatggctt   1560

tcgctacctg gagagacgcg cccgctgatc ctttgcgaat acgcccacgc gatgggtaac   1620

agtcttggcg gtttcgctaa atactggcag gcgtttcgtc agtatccccg tttacagggc   1680

ggcttcgtct gggactgggt ggatcagtcg ctgattaaat atgatgaaaa cggcaacccg   1740

tggtcggctt acggcggtga ttttggcgat acgccgaacg atcgccagtt ctgtatgaac   1800

ggtctggtct ttgccgaccg cacgccgcat ccagcgctga cggaagcaaa acaccagcag   1860

cagtttttcc agttccgttt atccgggcaa accatcgaag tgaccagcga atacctgttc   1920

cgtcatagcg ataacgagct cctgcactgg atggtggcgc tggatggtaa gccgctggca   1980

agcggtgaag tgcctctgga tgtcgctcca caaggtaaac agttgattga actgcctgaa   2040

ctaccgcagc cggagagcgc cgggcaactc tggctcacag tacgcgtagt gcaaccgaac   2100

gcgaccgcat ggtcagaagc cgggcacatc agcgcctggc agcagtggcg tctggcggaa   2160

aacctcagtg tgacgctccc cgccgcgtcc cacgccatcc cgcatctgac caccagcgaa   2220

atggattttt gcatcgagct gggtaataag cgttggcaat ttaaccgcca gtcaggcttt   2280

ctttcacaga tgtggattgg cgataaaaaa caactgctga cgccgctgcg cgatcagttc   2340

acccgtgcac cgctggataa cgacattggc gtaagtgaag cgacccgcat tgaccctaac   2400

gcctgggtcg aacgctggaa ggcggcgggc cattaccagg ccgaagcagc gttgttgcag   2460

tgcacggcag atacacttgc tgatgcggtg ctgattacga ccgctcacgc gtggcagcat   2520

caggggaaaa ccttatttat cagccggaaa acctaccgga ttgatggtag tggtcaaatg   2580

gcgattaccg ttgatgttga agtggcgagc gatacaccgc atccggcgcg gattggcctg   2640

aactgccagc tggcgcaggt agcagagcgg gtaaactggc tcggattagg gccgcaagaa   2700

aactatcccg accgccttac tgccgcctgt tttgaccgct gggatctgcc attgtcagac   2760

atgtataccc cgtacgtctt cccgagcgaa aacggtctgc gctgcgggac gcgcgaattg   2820

aattatggcc cacaccagtg gcgcggcgac ttccagttca acatcagccg ctacagtcaa   2880

cagcaactga tggaaaccag ccatcgccat ctgctgcacg cggaagaagg cacatggctg   2940

aatatcgacg gtttccatat ggggattggt ggcgacgact cctggagccc gtcagtatcg   3000

gcggaattcc agctgagcgc cggtcgctac cattaccagt tggtctggtg tcaaaaagcg   3060

gccgctcgag tctag                                                    3075


<210>  43
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  human secreted alkaline phosphatase gene

<400>  43
atgattctgg ggccctgcat gctgctgctg ctgctgctgc tgggcctgag gctacagctc     60

tccctgggca tcatcccagt tgaggaggag aacccggact tctggaaccg cgaggcagcc    120

gaggccctgg gtgccgccaa gaagctgcag cctgcacaga cagccgccaa gaacctcatc    180

atcttcctgg gcgatgggat gggggtgtct acggtgacag ctgccaggat cctaaaaggg    240

cagaagaagg acaaactggg gcctgagata cccctggcta tggaccgctt cccatatgtg    300

gctctgtcca agacatacaa tgtagacaaa catgtgccag acagtggagc cacagccacg    360

gcctacctgt gcggggtcaa gggcaacttc cagaccattg gcttgagtgc agccgcccgc    420

tttaaccagt gcaacacgac acgcggcaac gaggtcatct ccgtgatgaa tcgggccaag    480

aaagcaggga agtcagtggg agtggtaacc accacacgag tgcagcacgc ctcgccagcc    540

ggcacctacg cccacacggt gaaccgcaac tggtactcgg acgccgacgt gcctgcctcg    600

gcccgccagg aggggtgcca ggacatcgct acgcagctca tctccaacat ggacattgat    660

gtgatcctgg gtggaggccg aaagtacatg tttcgcatgg gaaccccaga ccctgagtac    720

ccagatgact acagccaagg tgggaccagg ctggacggga agaatctggt gcaggaatgg    780

ctggcgaagc gccagggtgc ccggtatgtg tggaaccgca ctgagctcat gcaggcttcc    840

ctggacccgt ctgtgaccca tctcatgggt ctctttgagc ctggagacat gaaatacgag    900

atccaccgag actccacact ggacccctcc ctgatggaga tgacagaggc tgccctgcgc    960

ctgctgagca ggaacccccg cggcttcttc ctcttcgtgg agggtggtcg catcgaccac   1020

ggtcatcacg aaagcagggc ttaccgggca ctgactgaga cgatcatgtt cgacgacgcc   1080

attgagaggg cgggccagct caccagcgag gaggacacgc tgagcctcgt cactgccgac   1140

cactcccacg tcttctcctt cggaggctac cccctgcgag ggagctccat cttcgggctg   1200

gcccctggca aggcccggga caggaaggcc tacacggtcc tcctatacgg aaacggtcca   1260

ggctatgtgc tcaaggacgg cgcccggccg gatgttaccg agagcgagag cgggagcccc   1320

gagtatcggc agcagtcagc agtgcccctg gacgaagaga cccacgcagg cgaggacgtg   1380

gcggtgttcg cgcgcggccc gcaggcgcac ctggttcacg gcgtgcagga gcagaccttc   1440

atagcgcacg tcatggcctt cgccgcctgc ctggagccct acaccgcctg cgacctggcg   1500

ccccccgccg gcaccaccga cgccgcgcac ccggggcggt cccggtccaa gcgtctggat   1560

tga                                                                 1563


<210>  44
<211>  1524
<212>  DNA
<213>  Artificial

<220>
<223>  murine secreted alkaline phosphatase gene

<400>  44
atgtggggtg cctgtctgct attgctgggc ttaagtcttc aagtttgccc cagtgtcatt     60

cctgtggagg aggagaatcc tgctttttgg aataggaagg cagctgaagc cttggatgca    120

gccaagaagc tcaagcccat tcagacatct gcaaagaatc ttgtcatcct catgggtgat    180

ggaatgggtg tctccactgt aacagccacc aggattctga agggccagca acaaggtcat    240

ctaggcccag agacccagtt ggcaatggac aggttccctc acatggccct ttccaagact    300

tacaacactg acaagcagat tcctgactct gctgggacag gcacagcatt cttgtgtgga    360

gtaaaaacca acatgaaagt cattggtctt tcagctgctg ccagattcaa ccagtgcaac    420

accacatggg gcaatgaagt ggtctctgta atgcacaggg ccaaaaaagc tgggaaaagt    480

gtgggtgtgg tgacaaccac ctctgtccag catgcctctc ctgctggaac ttatgcccac    540

acagtgaaca gaggttggta ctctgatgct cagatgcctg cctcagcttt acaagatggc    600

tgcaaggaca tcagcaccca gctcatctca aacatggaca tagatgtcat cttagggggt    660

gggagaaagt tcatgttccc aaaggggact cctgaccagg agtaccccac agacacaaag    720

caggctggca caagattaga tggtaggaac cttgtgcaag agtggcttgc caagcatcag    780

ggagcaaggt atgtctggaa caggagtgag ctaatccagg cctctttgaa caggtctgtc    840

actcacctaa tggggttatt tgagcccaat gacatgaagt atgagataca cagggaccct    900

gcccaggacc cctccttagc agaaatgact gaagttgctg tgaggatgtt gtccagaaat    960

ccaaaagggt tctacctctt tgttgagggg ggaaggattg atcatggtca ccatgagaca   1020

gttgcttaca gagccttaac tgaggctgtg atgtttgatt ctgctgtgga caaggctgac   1080

aaactgacct ctgagcagga cacaatgatt ctagtgactg ctgaccacag tcatgttttc   1140

tcctttgggg gctacaccca gaggggtgct tcaatctttg gcctggcccc tttcaaggca   1200

gaagatggga agagtttcac ctccatcctc tatgggaatg gtcctgggta caagctgcac   1260

aatggggcca gagctgatgt gacagaagag gagagctcca acccaaccta ccagcagcaa   1320

gcagcagtcc ctctttcttc agaaacccac tctggggaag atgtggccat atttgccaga   1380

ggcccccaag cccacttggt gcatggagtt caggagcaga attacatagc tcatgtaatg   1440

gcttttgctg cttgcttgga gccctacaca gactgtggcc tagccagccc agcaggccag   1500

tcctctgcag taagcccagg ctag                                          1524


<210>  45
<211>  10613
<212>  DNA
<213>  Artificial

<220>
<223>  pIM-RAG1-MCS

<400>  45
ggcgcgccag atctgtacat tcgaagatat cttaattaag cggccgctcg agtctagagg     60

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    120

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    180

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    240

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    300

ggtgggctct atggcttctg aggcggaaag aacggatccg cagcctcttt cccacccacc    360

ttgggactca gttctgcccc agatgaaatt cagcacccac atattaaatt ttcagaatgg    420

aaatttaagc tgttccgggt gagatccttt gaaaagacac ctgaagaagc tcaaaaggaa    480

aagaaggatt cctttgaggg gaaaccctct ctggagcaat ctccagcagt cctggacaag    540

gctgatggtc agaagccagt cccaactcag ccattgttaa aagcccaccc taagttttcg    600

aagaaatttc acgacaacga gaaagcaaga ggcaaagcga tccatcaagc caaccttcga    660

catctctgcc gcatctgtgg gaattctttt agagctgatg agcacaacag gagatatcca    720

gtccatggtc ctgtggatgg taaaacccta ggccttttac gaaagaagga aaagagagct    780

acttcctggc cggacctcat tgccaaggtt ttccggatcg atgtgaaggc agatgttgac    840

tcgatccacc ccactgagtt ctgccataac tgctggagca tcatgcacag gaagtttagc    900

agtgccccat gtgaggttta cttcccgagg aacgtgacca tggagtggca cccccacaca    960

ccatcctgtg acatctgcaa cactgcccgt cggggactca agaggaagag tcttcagcca   1020

aacttgcagc tcagcaaaaa actcaaaact gtgcttgacc aagcaagaca agcccgtcag   1080

cacaagagaa gagctcaggc aaggatcagc agcaaggatg tcatgaagaa gatcgccaac   1140

tgcagtaaga tacatcttag taccaagctc cttgcagtgg acttcccaga gcactttgtg   1200

aaatccatct cctgccagat ctgtgaacac attctggctg accctgtgga gaccaactgt   1260

aagcatgtct tttgccgggt ctgcattctc agatgcctca aagtcatggg cagctattgt   1320

ccctcttgcc gatatccatg cttccctact gacctggaga gtccagtgaa gtcctttctg   1380

agcgtcttga attccctgat ggtgaaatgt ccagcaaaag agtgcaatga ggaggtcagt   1440

ttggaaaaat ataatcacca catctcaagt cacaaggaat caaaagagat ttttgtgcac   1500

attaataaag ggggtcgagt aacgcgtgca ggcatgcaag ctggccgcaa taaaatatct   1560

ttattttcat tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac atacgctctc   1620

catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag tgcaagtgca   1680

ggtgccagaa catttctcta tcgaaggatc tgcgatcgct ccggtgcccg tcagtgggca   1740

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt   1800

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt   1860

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt   1920

cgcaacgggt ttgccgccag aacacagctg aagcttcgag gggctcgcat ctctccttca   1980

cgcgcccgcc gccctacctg aggccgccat ccacgccggt tgagtcgcgt tctgccgcct   2040

cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg   2100

agaccgggcc tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg   2160

ctttgcctga ccctgcttgc tcaactctac gtctttgttt cgttttctgt tctgcgccgt   2220

tacagatcca agctgtgacc ggcgcctacg taagtgatat ctactagatt tatcaaaaag   2280

agtgttgact tgtgagcgct cacaattgat acttagattc atcgagaggg acacgtcgac   2340

tactaacctt cttctctttc ctacagctga gatcaccggc gaaggagggc caccatggct   2400

tcttaccctg gacaccagca tgcttctgcc tttgaccagg ctgccagatc caggggccac   2460

tccaacagga gaactgccct aagacccaga agacagcagg aagccactga ggtgaggcct   2520

gagcagaaga tgccaaccct gctgagggtg tacattgatg gacctcatgg catgggcaag   2580

accaccacca ctcaactgct ggtggcactg ggctccaggg atgacattgt gtatgtgcct   2640

gagccaatga cctactggag agtgctagga gcctctgaga ccattgccaa catctacacc   2700

acccagcaca ggctggacca gggagaaatc tctgctggag atgctgctgt ggtgatgacc   2760

tctgcccaga tcacaatggg aatgccctat gctgtgactg atgctgttct ggctcctcac   2820

attggaggag aggctggctc ttctcatgcc cctccacctg ccctgaccct gatctttgac   2880

agacacccca ttgcagccct gctgtgctac ccagcagcaa ggtacctcat gggctccatg   2940

accccacagg ctgtgctggc ttttgtggcc ctgatccctc caaccctccc tggcaccaac   3000

attgttctgg gagcactgcc tgaagacaga cacattgaca ggctggcaaa gaggcagaga   3060

cctggagaga gactggacct ggccatgctg gctgcaatca gaagggtgta tggactgctg   3120

gcaaacactg tgagatacct ccagtgtgga ggctcttgga gagaggactg gggacagctc   3180

tctggaacag cagtgccccc tcaaggagct gagccccagt ccaatgctgg tccaagaccc   3240

cacattgggg acaccctgtt caccctgttc agagcccctg agctgctggc tcccaatgga   3300

gacctgtaca atgtgtttgc ctgggctctg gatgttctag ccaagaggct gaggtccatg   3360

catgtgttca tcctggacta tgaccagtcc cctgctggat gcagagatgc tctgctgcaa   3420

ctaacctctg gcatggtgca gacccatgtg accacccctg gcagcatccc caccatctgt   3480

gacctagcca gaacctttgc cagggagatg ggagaggcca actaaacctg agctagctcg   3540

acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat   3600

gctttatttg tgaaatttgt gatgctattg ctttatttgt gaaatttgtg atgctattgc   3660

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt   3720

tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa   3780

atgtggtaga tccatttttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt   3840

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg   3900

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg   3960

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc   4020

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc   4080

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata   4140

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg   4200

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct   4260

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa   4320

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc   4380

tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt   4440

aggtcgttcg ctccaagctg ggctgtgtgc acgacccccc cgttcagccc gaccgctgcg   4500

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg   4560

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct   4620

tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc   4680

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg   4740

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc   4800

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt   4860

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa   4920

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat   4980

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct   5040

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg   5100

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag   5160

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta   5220

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg   5280

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg   5340

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct   5400

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta   5460

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg   5520

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc   5580

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg   5640

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga   5700

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg   5760

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat   5820

gttgaatact catactcttc ctttttcaat attattgaag catttatcag ggttattgtc   5880

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca   5940

catttccccg aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct   6000

ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa   6060

acctctgaca catgcagctc ccggagacgg tcacagcttg tctgtaagcg gatgccggga   6120

gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact   6180

atgcggcatc agagcagatt gtactgagag tgcaccatat gcggtgtgaa ataccgcaca   6240

gatgcgtaag gagaaaatac cgcatcaggc gccaatatta aacttgatga gctctagaga   6300

tggtcatgca ttttaaaaag aattactcaa aatattgtct tggaatacca gagagcaagt   6360

gctttaagta taggctggga agtaaaatgc taaaggaatg agaaggcatt tggggttgag   6420

ttcaacctaa gaggcagggg agccacaggg aaagacctag cacctgccac agaagagaat   6480

taggaagcag aattgaacta taagcaattt tgaggtgttc gttgggctgc agttgaaata   6540

ttttttgagg ttaatgagac atttgaaatg gccgtgtatt gtttaactct tgcatagtcc   6600

tgcataggga acaatctaat aggatttctc tgtgaatcaa gtcttagaaa tttgctttta   6660

atttttatga aaaacgccca tttctttgtt tttgagacag agtcctgctc tgtcatccag   6720

gctgggttgc agtggcgtga tcttggccca ctgcaatctc tgcctcctgg gttcaggcaa   6780

ttttcctgtc tcagcctccc gagtagctgg gatttcaagt gcctgccacc atgcccggct   6840

aaattttttt gtatttttgg tacagatgga gtatcaccat gttggccagg ctggtctcga   6900

actcctgacc tcaagtgatt caccagcctt gacctcccaa agtgttggga tcacaggcat   6960

gagccactgt gcctgtgccc caaaacacca atttctgatg tgtgatgcat gtaagataga   7020

acaaacttca gtaaagcggg gacttgaaaa gaggctttgg taacagctgt cagcattaac   7080

ccttgcccct ccgtacctcc taatcccacc cctgctcaaa gtatgttcat ctgagaattt   7140

gtctccataa ctatgtgact ataaaaattc tcatcgattt tgttagttga tcaattgagg   7200

gaaaaacata tgttacttga tataactggt gggtcaaaag aattaaccca ggcaaatttg   7260

agataggtgg atgggatgat ggattgaaaa tacagctgct ctctttccaa tcatgtacta   7320

agtaatttgg gaaagattga tctaattggg tctagagagt acacttcaca tggcattgtt   7380

tgactttttt tctgcatcgc tagcgatctg tgcattacaa ctcaaatcag tcgggtttcc   7440

tggcatatgt aattgccaat gttttttacc agaagagaaa cattactccc acctcttctt   7500

attatgttac aaactatagt gctaatgacc atcgaccaac agtgactttc aggatgacct   7560

gtgtgagttt tatctgaaac catgtgaatt tttcatctta aaagtccctt agaatctcag   7620

tctatgtaca ctcaggtttg ttgcaggttt agagttccgt gttttttgtt tctaatgtag   7680

acacagcctt ataatttaca acagcattca ctaattaaaa ttgtaagcat aattactatc   7740

cacgatactt attattagtt tgcattcata aagctcaaaa ttcacttcat cctttcaagt   7800

agtgaataat tagtttcttt gggtttgcag ctttatcatc cttttatgac ccatttggaa   7860

gaaataaaca accaaccccc tggaagactg ctttaaaaag ctggaaatac attgtccagc   7920

tagtacaatg aggctaatac aatgtggaaa atattacttt tctttgattt tagtagcctg   7980

tttatcttta catttactga acaaataact attgagcacc taatgtatac tgggaccctt   8040

ggggaggcaa agatgaatca aagattctgt ccttaaagac cttaagacgc gttgacattg   8100

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat   8160

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc   8220

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca   8280

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta   8340

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta   8400

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat   8460

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga   8520

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca   8580

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg   8640

taggcgtgta cggtgggagg tctatataag cagagctccc cgggagcttg tatatccatt   8700

ttcggatctg atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg   8760

cacgcaggtt ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag   8820

acaatcggct gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt   8880

tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta   8940

tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg   9000

ggaagggact ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt   9060

gctcctgccg agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat   9120

ccggctacct gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg   9180

atggaagccg gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca   9240

gccgaactgt tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc   9300

catggcgatg cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc   9360

gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat   9420

attgctgaag agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc   9480

gctcccgatt cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgattaatt   9540

aacaggactg accgtgctac gagatttcga ttccaccgcc gccttctatg aaaggttggg   9600

cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct   9660

ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa   9720

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc   9780

caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc   9840

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa   9900

catacaggat ccactagcga tgtacgggcc agatatacgc gttgacattg attattgact   9960

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc  10020

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg  10080

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa  10140

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca  10200

agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac  10260

atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc  10320

atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga  10380

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg  10440

gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta  10500

cggtgggagg tctatataag cagagctctc tggctaacta gagaacccac tgcttactgg  10560

cttatcgaaa ttaatacgac tcactatagg gagacccaag ctggctagcc tta         10613


<210>  46
<211>  12415
<212>  DNA
<213>  Artificial

<220>
<223>  pIM-RAG1-Luc

<400>  46
atggaagatg ccaaaaacat taagaagggc ccagcgccat tctacccact cgaagacggg     60

accgccggcg agcagctgca caaagccatg aagcgctacg ccctggtgcc cggcaccatc    120

gcctttaccg acgcacatat cgaggtggac attacctacg ccgagtactt cgagatgagc    180

gttcggctgg cagaagctat gaagcgctat gggctgaata caaaccatcg gatcgtggtg    240

tgcagcgaga atagcttgca gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg    300

gctgtggccc cagctaacga catctacaac gagcgcgagc tgctgaacag catgggcatc    360

agccagccca ccgtcgtatt cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa    420

aagaagctac cgatcataca aaagatcatc atcatggata gcaagaccga ctaccagggc    480

ttccaaagca tgtacacctt cgtgacttcc catttgccac ccggcttcaa cgagtacgac    540

ttcgtgcccg agagcttcga ccgggacaaa accatcgccc tgatcatgaa cagtagtggc    600

agtaccggat tgcccaaggg cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt    660

catgcccgcg accccatctt cggcaaccag atcatccccg acaccgctat cctcagcgtg    720

gtgccatttc accacggctt cggcatgttc accacgctgg gctacttgat ctgcggcttt    780

cgggtcgtgc tcatgtaccg cttcgaggag gagctattct tgcgcagctt gcaagactat    840

aagattcaat ctgccctgct ggtgcccaca ctatttagct tcttcgctaa gagcactctc    900

atcgacaagt acgacctaag caacttgcac gagatcgcca gcggcggggc gccgctcagc    960

aaggaggtag gtgaggccgt ggccaaacgc ttccacctac caggcatccg ccagggctac   1020

ggcctgacag aaacaaccag cgccattctg atcacccccg aaggggacga caagcctggc   1080

gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg tggacttgga caccggtaag   1140

acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg gccccatgat catgagcggc   1200

tacgttaaca accccgaggc tacaaacgct ctcatcgaca aggacggctg gctgcacagc   1260

ggcgacatcg cctactggga cgaggacgag cacttcttca tcgtggaccg gctgaagagc   1320

ctgatcaaat acaagggcta ccaggtagcc ccagccgaac tggagagcat cctgctgcaa   1380

caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg   1440

cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga ccgagaagga gatcgtggac   1500

tatgtggcca gccaggttac aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac   1560

gaggtgccta aaggactgac cggcaagttg gacgcccgca agatccgcga gattctcatt   1620

aaggccaaga agggcggcaa gatcgccgtg taataattct agagtcgggg cggccggccg   1680

cttcgagcag acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag   1740

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattaaa   1800

acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc   1860

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag   1920

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag   1980

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct   2040

atggcttctg aggcggaaag aacggatccg cagcctcttt cccacccacc ttgggactca   2100

gttctgcccc agatgaaatt cagcacccac atattaaatt ttcagaatgg aaatttaagc   2160

tgttccgggt gagatccttt gaaaagacac ctgaagaagc tcaaaaggaa aagaaggatt   2220

cctttgaggg gaaaccctct ctggagcaat ctccagcagt cctggacaag gctgatggtc   2280

agaagccagt cccaactcag ccattgttaa aagcccaccc taagttttcg aagaaatttc   2340

acgacaacga gaaagcaaga ggcaaagcga tccatcaagc caaccttcga catctctgcc   2400

gcatctgtgg gaattctttt agagctgatg agcacaacag gagatatcca gtccatggtc   2460

ctgtggatgg taaaacccta ggccttttac gaaagaagga aaagagagct acttcctggc   2520

cggacctcat tgccaaggtt ttccggatcg atgtgaaggc agatgttgac tcgatccacc   2580

ccactgagtt ctgccataac tgctggagca tcatgcacag gaagtttagc agtgccccat   2640

gtgaggttta cttcccgagg aacgtgacca tggagtggca cccccacaca ccatcctgtg   2700

acatctgcaa cactgcccgt cggggactca agaggaagag tcttcagcca aacttgcagc   2760

tcagcaaaaa actcaaaact gtgcttgacc aagcaagaca agcccgtcag cacaagagaa   2820

gagctcaggc aaggatcagc agcaaggatg tcatgaagaa gatcgccaac tgcagtaaga   2880

tacatcttag taccaagctc cttgcagtgg acttcccaga gcactttgtg aaatccatct   2940

cctgccagat ctgtgaacac attctggctg accctgtgga gaccaactgt aagcatgtct   3000

tttgccgggt ctgcattctc agatgcctca aagtcatggg cagctattgt ccctcttgcc   3060

gatatccatg cttccctact gacctggaga gtccagtgaa gtcctttctg agcgtcttga   3120

attccctgat ggtgaaatgt ccagcaaaag agtgcaatga ggaggtcagt ttggaaaaat   3180

ataatcacca catctcaagt cacaaggaat caaaagagat ttttgtgcac attaataaag   3240

ggggtcgagt aacgcgtgca ggcatgcaag ctggccgcaa taaaatatct ttattttcat   3300

tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac atacgctctc catcaaaaca   3360

aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag tgcaagtgca ggtgccagaa   3420

catttctcta tcgaaggatc tgcgatcgct ccggtgcccg tcagtgggca gagcgcacat   3480

cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa   3540

ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg   3600

gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt   3660

ttgccgccag aacacagctg aagcttcgag gggctcgcat ctctccttca cgcgcccgcc   3720

gccctacctg aggccgccat ccacgccggt tgagtcgcgt tctgccgcct cccgcctgtg   3780

gtgcctcctg aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg agaccgggcc   3840

tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg ctttgcctga   3900

ccctgcttgc tcaactctac gtctttgttt cgttttctgt tctgcgccgt tacagatcca   3960

agctgtgacc ggcgcctacg taagtgatat ctactagatt tatcaaaaag agtgttgact   4020

tgtgagcgct cacaattgat acttagattc atcgagaggg acacgtcgac tactaacctt   4080

cttctctttc ctacagctga gatcaccggc gaaggagggc caccatggct tcttaccctg   4140

gacaccagca tgcttctgcc tttgaccagg ctgccagatc caggggccac tccaacagga   4200

gaactgccct aagacccaga agacagcagg aagccactga ggtgaggcct gagcagaaga   4260

tgccaaccct gctgagggtg tacattgatg gacctcatgg catgggcaag accaccacca   4320

ctcaactgct ggtggcactg ggctccaggg atgacattgt gtatgtgcct gagccaatga   4380

cctactggag agtgctagga gcctctgaga ccattgccaa catctacacc acccagcaca   4440

ggctggacca gggagaaatc tctgctggag atgctgctgt ggtgatgacc tctgcccaga   4500

tcacaatggg aatgccctat gctgtgactg atgctgttct ggctcctcac attggaggag   4560

aggctggctc ttctcatgcc cctccacctg ccctgaccct gatctttgac agacacccca   4620

ttgcagccct gctgtgctac ccagcagcaa ggtacctcat gggctccatg accccacagg   4680

ctgtgctggc ttttgtggcc ctgatccctc caaccctccc tggcaccaac attgttctgg   4740

gagcactgcc tgaagacaga cacattgaca ggctggcaaa gaggcagaga cctggagaga   4800

gactggacct ggccatgctg gctgcaatca gaagggtgta tggactgctg gcaaacactg   4860

tgagatacct ccagtgtgga ggctcttgga gagaggactg gggacagctc tctggaacag   4920

cagtgccccc tcaaggagct gagccccagt ccaatgctgg tccaagaccc cacattgggg   4980

acaccctgtt caccctgttc agagcccctg agctgctggc tcccaatgga gacctgtaca   5040

atgtgtttgc ctgggctctg gatgttctag ccaagaggct gaggtccatg catgtgttca   5100

tcctggacta tgaccagtcc cctgctggat gcagagatgc tctgctgcaa ctaacctctg   5160

gcatggtgca gacccatgtg accacccctg gcagcatccc caccatctgt gacctagcca   5220

gaacctttgc cagggagatg ggagaggcca actaaacctg agctagctcg acatgataag   5280

atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg   5340

tgaaatttgt gatgctattg ctttatttgt gaaatttgtg atgctattgc tttatttgta   5400

accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag   5460

gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtaga   5520

tccatttttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac   5580

aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt   5640

gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc   5700

gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg   5760

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt   5820

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa   5880

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc   5940

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag   6000

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt   6060

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg   6120

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg   6180

ctccaagctg ggctgtgtgc acgacccccc cgttcagccc gaccgctgcg ccttatccgg   6240

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac   6300

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg   6360

gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt   6420

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg   6480

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc   6540

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt   6600

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt   6660

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag   6720

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt   6780

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc   6840

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc   6900

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg   6960

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac   7020

aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg   7080

atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc   7140

tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact   7200

gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc   7260

aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat   7320

acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc   7380

ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac   7440

tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa   7500

aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact   7560

catactcttc ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg   7620

atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg   7680

aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag   7740

gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa acctctgaca   7800

catgcagctc ccggagacgg tcacagcttg tctgtaagcg gatgccggga gcagacaagc   7860

ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact atgcggcatc   7920

agagcagatt gtactgagag tgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag   7980

gagaaaatac cgcatcaggc gccaatatta aacttgatga gctctagaga tggtcatgca   8040

ttttaaaaag aattactcaa aatattgtct tggaatacca gagagcaagt gctttaagta   8100

taggctggga agtaaaatgc taaaggaatg agaaggcatt tggggttgag ttcaacctaa   8160

gaggcagggg agccacaggg aaagacctag cacctgccac agaagagaat taggaagcag   8220

aattgaacta taagcaattt tgaggtgttc gttgggctgc agttgaaata ttttttgagg   8280

ttaatgagac atttgaaatg gccgtgtatt gtttaactct tgcatagtcc tgcataggga   8340

acaatctaat aggatttctc tgtgaatcaa gtcttagaaa tttgctttta atttttatga   8400

aaaacgccca tttctttgtt tttgagacag agtcctgctc tgtcatccag gctgggttgc   8460

agtggcgtga tcttggccca ctgcaatctc tgcctcctgg gttcaggcaa ttttcctgtc   8520

tcagcctccc gagtagctgg gatttcaagt gcctgccacc atgcccggct aaattttttt   8580

gtatttttgg tacagatgga gtatcaccat gttggccagg ctggtctcga actcctgacc   8640

tcaagtgatt caccagcctt gacctcccaa agtgttggga tcacaggcat gagccactgt   8700

gcctgtgccc caaaacacca atttctgatg tgtgatgcat gtaagataga acaaacttca   8760

gtaaagcggg gacttgaaaa gaggctttgg taacagctgt cagcattaac ccttgcccct   8820

ccgtacctcc taatcccacc cctgctcaaa gtatgttcat ctgagaattt gtctccataa   8880

ctatgtgact ataaaaattc tcatcgattt tgttagttga tcaattgagg gaaaaacata   8940

tgttacttga tataactggt gggtcaaaag aattaaccca ggcaaatttg agataggtgg   9000

atgggatgat ggattgaaaa tacagctgct ctctttccaa tcatgtacta agtaatttgg   9060

gaaagattga tctaattggg tctagagagt acacttcaca tggcattgtt tgactttttt   9120

tctgcatcgc tagcgatctg tgcattacaa ctcaaatcag tcgggtttcc tggcatatgt   9180

aattgccaat gttttttacc agaagagaaa cattactccc acctcttctt attatgttac   9240

aaactatagt gctaatgacc atcgaccaac agtgactttc aggatgacct gtgtgagttt   9300

tatctgaaac catgtgaatt tttcatctta aaagtccctt agaatctcag tctatgtaca   9360

ctcaggtttg ttgcaggttt agagttccgt gttttttgtt tctaatgtag acacagcctt   9420

ataatttaca acagcattca ctaattaaaa ttgtaagcat aattactatc cacgatactt   9480

attattagtt tgcattcata aagctcaaaa ttcacttcat cctttcaagt agtgaataat   9540

tagtttcttt gggtttgcag ctttatcatc cttttatgac ccatttggaa gaaataaaca   9600

accaaccccc tggaagactg ctttaaaaag ctggaaatac attgtccagc tagtacaatg   9660

aggctaatac aatgtggaaa atattacttt tctttgattt tagtagcctg tttatcttta   9720

catttactga acaaataact attgagcacc taatgtatac tgggaccctt ggggaggcaa   9780

agatgaatca aagattctgt ccttaaagac cttaagacgc gttgacattg attattgact   9840

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc   9900

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg   9960

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa  10020

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca  10080

agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac  10140

atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc  10200

atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga  10260

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg  10320

gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta  10380

cggtgggagg tctatataag cagagctccc cgggagcttg tatatccatt ttcggatctg  10440

atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt  10500

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct  10560

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga  10620

ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta tcgtggctgg  10680

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact  10740

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg  10800

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct  10860

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg  10920

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt  10980

tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg  11040

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc  11100

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag  11160

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt  11220

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgattaatt aacaggactg  11280

accgtgctac gagatttcga ttccaccgcc gccttctatg aaaggttggg cttcggaatc  11340

gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct ggagttcttc  11400

gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca  11460

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc  11520

aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc gtaatcatgg  11580

tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacaggat  11640

ccactagcga tgtacgggcc agatatacgc gttgacattg attattgact agttattaat  11700

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac  11760

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa  11820

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt  11880

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc  11940

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat  12000

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc  12060

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc  12120

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa  12180

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg  12240

tctatataag cagagctctc tggctaacta gagaacccac tgcttactgg cttatcgaaa  12300

ttaatacgac tcactatagg gagacccaag ctggctagcc ttaggcgcgc cagatctgta  12360

cattcgaaga tatcttaatt aagcggccgc gaattcacta gtgattgcag aattc       12415


<210>  47
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  F_HS1_PCRSC primer

<400>  47
ggaggattgg gaagacaata gc                                              22


<210>  48
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  R_HS1_PCRSC primer

<400>  48
ctttcacagt cctgtacatc ttgt                                            24

<210>  49
<211>  717
<212>  DNA
<213>  Artificial

<220>
<223>  TagGFP2

<400>  49
atgagcgggg gcgaggagct gttcgccggc atcgtgcccg tgctgatcga gctggacggc     60

gacgtgcacg gccacaagtt cagcgtgcgc ggcgagggcg agggcgacgc cgactacggc    120

aagctggaga tcaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctg    180

gtgaccaccc tctgctacgg catccagtgc ttcgcccgct accccgagca catgaagatg    240

aacgacttct tcaagagcgc catgcccgag ggctacatcc aggagcgcac catccagttc    300

caggacgacg gcaagtacaa gacccgcggc gaggtgaagt tcgagggcga caccctggtg    360

aaccgcatcg agctgaaggg caaggacttc aaggaggacg gcaacatcct gggccacaag    420

ctggagtaca gcttcaacag ccacaacgtg tacatccgcc ccgacaaggc caacaacggc    480

ctggaggcta acttcaagac ccgccacaac atcgagggcg gcggcgtgca gctggccgac    540

cactaccaga ccaacgtgcc cctgggcgac ggccccgtgc tgatccccat caaccactac    600

ctgagcactc agaccaagat cagcaaggac cgcaacgagg cccgcgacca catggtgctc    660

ctggagtcct tcagcgcctg ctgccacacc cacggcatgg acgagctgta caggtaa       717

<210>  50
<211>  11805
<212>  DNA
<213>  Artificial

<220>
<223>  pIM-RAG1-EF1-MCS

<400>  50
gtttaaacaa tattcctgca gggcagcccg gggagcggcc gcggagctcc aggaattctg     60

cagatcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    120

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    180

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    240

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggatccgca    300

gcctctttcc cacccacctt gggactcagt tctgccccag atgaaattca gcacccacat    360

attaaatttt cagaatggaa atttaagctg ttccgggtga gatcctttga aaagacacct    420

gaagaagctc aaaaggaaaa gaaggattcc tttgagggga aaccctctct ggagcaatct    480

ccagcagtcc tggacaaggc tgatggtcag aagccagtcc caactcagcc attgttaaaa    540

gcccacccta agttttcgaa gaaatttcac gacaacgaga aagcaagagg caaagcgatc    600

catcaagcca accttcgaca tctctgccgc atctgtggga attcttttag agctgatgag    660

cacaacagga gatatccagt ccatggtcct gtggatggta aaaccctagg ccttttacga    720

aagaaggaaa agagagctac ttcctggccg gacctcattg ccaaggtttt ccggatcgat    780

gtgaaggcag atgttgactc gatccacccc actgagttct gccataactg ctggagcatc    840

atgcacagga agtttagcag tgccccatgt gaggtttact tcccgaggaa cgtgaccatg    900

gagtggcacc cccacacacc atcctgtgac atctgcaaca ctgcccgtcg gggactcaag    960

aggaagagtc ttcagccaaa cttgcagctc agcaaaaaac tcaaaactgt gcttgaccaa   1020

gcaagacaag cccgtcagca caagagaaga gctcaggcaa ggatcagcag caaggatgtc   1080

atgaagaaga tcgccaactg cagtaagata catcttagta ccaagctcct tgcagtggac   1140

ttcccagagc actttgtgaa atccatctcc tgccagatct gtgaacacat tctggctgac   1200

cctgtggaga ccaactgtaa gcatgtcttt tgccgggtct gcattctcag atgcctcaaa   1260

gtcatgggca gctattgtcc ctcttgccga tatccatgct tccctactga cctggagagt   1320

ccagtgaagt cctttctgag cgtcttgaat tccctgatgg tgaaatgtcc agcaaaagag   1380

tgcaatgagg aggtcagttt ggaaaaatat aatcaccaca tctcaagtca caaggaatca   1440

aaagagattt ttgtgcacat taataaaggg ggtcgagtaa cgcgtgcagg catgcaagct   1500

ggccgcaata aaatatcttt attttcatta catctgtgtg ttggtttttt gtgtgaatcg   1560

taactaacat acgctctcca tcaaaacaaa acgaaacaaa acaaactagc aaaataggct   1620

gtccccagtg caagtgcagg tgccagaaca tttctctatc gaaggatctg cgatcgctcc   1680

ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg   1740

gtcggcaatt gaaccggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc   1800

gtgtactggc tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc   1860

gccgtgaacg ttctttttcg caacgggttt gccgccagaa cacagctgaa gcttcgaggg   1920

gctcgcatct ctccttcacg cgcccgccgc cctacctgag gccgccatcc acgccggttg   1980

agtcgcgttc tgccgcctcc cgcctgtggt gcctcctgaa ctgcgtccgc cgtctaggta   2040

agtttaaagc tcaggtcgag accgggcctt tgtccggcgc tcccttggag cctacctaga   2100

ctcagccggc tctccacgct ttgcctgacc ctgcttgctc aactctacgt ctttgtttcg   2160

ttttctgttc tgcgccgtta cagatccaag ctgtgaccgg cgcctacgta agtgatatct   2220

actagattta tcaaaaagag tgttgacttg tgagcgctca caattgatac ttagattcat   2280

cgagagggac acgtcgacta ctaaccttct tctctttcct acagctgaga tcaccggcga   2340

aggagggcca ccatggcttc ttaccctgga caccagcatg cttctgcctt tgaccaggct   2400

gccagatcca ggggccactc caacaggaga actgccctaa gacccagaag acagcaggaa   2460

gccactgagg tgaggcctga gcagaagatg ccaaccctgc tgagggtgta cattgatgga   2520

cctcatggca tgggcaagac caccaccact caactgctgg tggcactggg ctccagggat   2580

gacattgtgt atgtgcctga gccaatgacc tactggagag tgctaggagc ctctgagacc   2640

attgccaaca tctacaccac ccagcacagg ctggaccagg gagaaatctc tgctggagat   2700

gctgctgtgg tgatgacctc tgcccagatc acaatgggaa tgccctatgc tgtgactgat   2760

gctgttctgg ctcctcacat tggaggagag gctggctctt ctcatgcccc tccacctgcc   2820

ctgaccctga tctttgacag acaccccatt gcagccctgc tgtgctaccc agcagcaagg   2880

tacctcatgg gctccatgac cccacaggct gtgctggctt ttgtggccct gatccctcca   2940

accctccctg gcaccaacat tgttctggga gcactgcctg aagacagaca cattgacagg   3000

ctggcaaaga ggcagagacc tggagagaga ctggacctgg ccatgctggc tgcaatcaga   3060

agggtgtatg gactgctggc aaacactgtg agatacctcc agtgtggagg ctcttggaga   3120

gaggactggg gacagctctc tggaacagca gtgccccctc aaggagctga gccccagtcc   3180

aatgctggtc caagacccca cattggggac accctgttca ccctgttcag agcccctgag   3240

ctgctggctc ccaatggaga cctgtacaat gtgtttgcct gggctctgga tgttctagcc   3300

aagaggctga ggtccatgca tgtgttcatc ctggactatg accagtcccc tgctggatgc   3360

agagatgctc tgctgcaact aacctctggc atggtgcaga cccatgtgac cacccctggc   3420

agcatcccca ccatctgtga cctagccaga acctttgcca gggagatggg agaggccaac   3480

taaacctgag ctagctcgac atgataagat acattgatga gtttggacaa accacaacta   3540

gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtga   3600

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa   3660

caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag   3720

caagtaaaac ctctacaaat gtggtagatc atttagcttg gcgtaatcat ggtcatagct   3780

gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag ccggaagcat   3840

aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg cgttgcgctc   3900

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg   3960

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct   4020

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt   4080

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc   4140

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga   4200

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata   4260

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac   4320

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg   4380

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc   4440

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag   4500

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt   4560

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt   4620

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg   4680

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac   4740

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca   4800

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac   4860

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac   4920

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt   4980

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt   5040

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt   5100

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc   5160

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa   5220

tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg   5280

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt   5340

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc   5400

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt   5460

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg   5520

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac   5580

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc   5640

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt   5700

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg   5760

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat attattgaag   5820

catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa   5880

acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct aagaaaccat   5940

tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg   6000

tttcggtgat gacggtgaaa acctctgaca catgcagctc ccggagacgg tcacagcttg   6060

tctgtaagcg gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg   6120

gtgtcggggc tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat   6180

gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gccaatatta   6240

aacttgatga gctctagaga tggtcatgca ttttaaaaag aattactcaa aatattgtct   6300

tggaatacca gagagcaagt gctttaagta taggctggga agtaaaatgc taaaggaatg   6360

agaaggcatt tggggttgag ttcaacctaa gaggcagggg agccacaggg aaagacctag   6420

cacctgccac agaagagaat taggaagcag aattgaacta taagcaattt tgaggtgttc   6480

gttgggctgc agttgaaata ttttttgagg ttaatgagac atttgaaatg gccgtgtatt   6540

gtttaactct tgcatagtcc tgcataggga acaatctaat aggatttctc tgtgaatcaa   6600

gtcttagaaa tttgctttta atttttatga aaaacgccca tttctttgtt tttgagacag   6660

agtcctgctc tgtcatccag gctgggttgc agtggcgtga tcttggccca ctgcaatctc   6720

tgcctcctgg gttcaggcaa ttttcctgtc tcagcctccc gagtagctgg gatttcaagt   6780

gcctgccacc atgcccggct aaattttttt gtatttttgg tacagatgga gtatcaccat   6840

gttggccagg ctggtctcga actcctgacc tcaagtgatt caccagcctt gacctcccaa   6900

agtgttggga tcacaggcat gagccactgt gcctgtgccc caaaacacca atttctgatg   6960

tgtgatgcat gtaagataga acaaacttca gtaaagcggg gacttgaaaa gaggctttgg   7020

taacagctgt cagcattaac ccttgcccct ccgtacctcc taatcccacc cctgctcaaa   7080

gtatgttcat ctgagaattt gtctccataa ctatgtgact ataaaaattc tcatcgattt   7140

tgttagttga tcaattgagg gaaaaacata tgttacttga tataactggt gggtcaaaag   7200

aattaaccca ggcaaatttg agataggtgg atgggatgat ggattgaaaa tacagctgct   7260

ctctttccaa tcatgtacta agtaatttgg gaaagattga tctaattggg tctagagagt   7320

acacttcaca tggcattgtt tgactttttt tctgcatcgc tagcgatctg tgcattacaa   7380

ctcaaatcag tcgggtttcc tggcatatgt aattgccaat gttttttacc agaagagaaa   7440

cattactccc acctcttctt attatgttac aaactatagt gctaatgacc atcgaccaac   7500

agtgactttc aggatgacct gtgtgagttt tatctgaaac catgtgaatt tttcatctta   7560

aaagtccctt agaatctcag tctatgtaca ctcaggtttg ttgcaggttt agagttccgt   7620

gttttttgtt tctaatgtag acacagcctt ataatttaca acagcattca ctaattaaaa   7680

ttgtaagcat aattactatc cacgatactt attattagtt tgcattcata aagctcaaaa   7740

ttcacttcat cctttcaagt agtgaataat tagtttcttt gggtttgcag ctttatcatc   7800

cttttatgac ccatttggaa gaaataaaca accaaccccc tggaagactg ctttaaaaag   7860

ctggaaatac attgtccagc tagtacaatg aggctaatac aatgtggaaa atattacttt   7920

tctttgattt tagtagcctg tttatcttta catttactga acaaataact attgagcacc   7980

taatgtatac tgggaccctt ggggaggcaa agatgaatca aagattctgt ccttaaagac   8040

cttaagttaa gacgcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg   8100

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc   8160

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca   8220

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg   8280

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg   8340

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt   8400

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca   8460

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg   8520

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact   8580

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag   8640

ctccccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat gaggatcgtt   8700

tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct   8760

attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct   8820

gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga   8880

actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc   8940

tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg   9000

gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc   9060

aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca   9120

tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga   9180

cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc   9240

cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga   9300

aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca   9360

ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg   9420

cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct   9480

tcttgacgag ttcttctgat taattaacag gactgaccgt gctacgagat ttcgattcca   9540

ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga   9600

tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg tttattgcag   9660

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt   9720

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgtatac   9780

cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt   9840

gttatccgct cacaattcca cacaacatac aggatccact agtaacggcc gccagtgtgc   9900

tggaattccg aggtcgacgg tatcgataag ggcgcgccaa agctaactgt aggactgagt   9960

ctattctaaa ctgaaagcct ggacatctgg agtaccaggg ggagatgacg tgttacgggc  10020

ttccataaaa gcagctggct ttgaatggaa ggagccaaga ggccagcaca ggagcggatt  10080

cgtcgctttc acggccatcg agccgaacct ctcgcaagtc cgtgagccgt taaggaggcc  10140

cccagtcccg acccttcgcc ccaagcccct cggggtcccc gggcctggta ctccttgcca  10200

cacgggaggg gcgcggaagc cggggcggag gaggagccaa ccccgggctg ggctgagacc  10260

cgcagaggaa gacgctctag ggatttgtcc cggactagcg agatggcaag gctgaggacg  10320

ggaggctgat tgagaggcga aggtacaccc taatctcaat acaacctttg gagctaagcc  10380

agcaatggta gagggaagat tctgcacgtc ccttccaggc ggcctccccg tcaccacccc  10440

ccccaacccg ccccgaccgg agctgagagt aattcataca aaaggactcg cccctgcctt  10500

ggggaatccc agggaccgtc gttaaactcc cactaacgta gaacccagag atcgctgcgt  10560

tcccgccccc tcacccgccc gctctcgtca tcactgaggt ggagaagagc atgcgtgagg  10620

ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca gtccccgaga agttgggggg  10680

aggggtcggc aattgaaccg gtgcctagag aaggtggcgc ggggtaaact gggaaagtga  10740

tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata taagtgcagt  10800

agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt  10860

gtgtggttcc cgcgggcctg gcctctttac gggttatggc ccttgcgtgc cttgaattac  10920

ttccacgccc ctggctgcag tacgtgattc ttgatcccga gcttcgggtt ggaagtgggt  10980

gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct  11040

ggcttgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc tgtctcgctg  11100

ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg ctttttttct  11160

ggcaagatag tcttgtaaat gcgggccaag atcgatctgc acactggtat ttcggttttt  11220

ggggccgcgg gcggcgacgg ggcccgtgcg tcccagcgca catgttcggc gaggcggggc  11280

ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc aagctggccg gcctgctctg  11340

gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg cggcaaggct ggcccggtcg  11400

gcaccagttg cgtgagcgga aagatggccg cttcccggcc ctgctgcagg gagctcaaaa  11460

tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac ccacacaaag gaaaagggcc  11520

tttccgtcct cagccgtcgc ttcatgtgac tccacggagt accgggcgcc gtccaggcac  11580

ctcgattagt tctcgagctt ttggagtacg tcgtctttag gttgggggga ggggttttat  11640

gcgatggagt ttccccacac tgagtgggtg gagactgaag ttaggccagc ttggcacttg  11700

atgtaattct ccttggaatt tgcccttttt gagtttggat cttggttcat tctcaagcct  11760

cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt cgtgg                  11805

<210>  51
<211>  10688
<212>  DNA
<213>  Artificial

<220>
<223>  pIM-RAG1-GAS5-MCS

<400>  51
gtttaaacaa tattcctgca gggcagcccg gggagcggcc gcggagctcc aggaattctg     60

cagatcactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc    120

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg    180

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg    240

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggatccgcag    300

cctctttccc acccaccttg ggactcagtt ctgccccaga tgaaattcag cacccacata    360

ttaaattttc agaatggaaa tttaagctgt tccgggtgag atcctttgaa aagacacctg    420

aagaagctca aaaggaaaag aaggattcct ttgaggggaa accctctctg gagcaatctc    480

cagcagtcct ggacaaggct gatggtcaga agccagtccc aactcagcca ttgttaaaag    540

cccaccctaa gttttcgaag aaatttcacg acaacgagaa agcaagaggc aaagcgatcc    600

atcaagccaa ccttcgacat ctctgccgca tctgtgggaa ttcttttaga gctgatgagc    660

acaacaggag atatccagtc catggtcctg tggatggtaa aaccctaggc cttttacgaa    720

agaaggaaaa gagagctact tcctggccgg acctcattgc caaggttttc cggatcgatg    780

tgaaggcaga tgttgactcg atccacccca ctgagttctg ccataactgc tggagcatca    840

tgcacaggaa gtttagcagt gccccatgtg aggtttactt cccgaggaac gtgaccatgg    900

agtggcaccc ccacacacca tcctgtgaca tctgcaacac tgcccgtcgg ggactcaaga    960

ggaagagtct tcagccaaac ttgcagctca gcaaaaaact caaaactgtg cttgaccaag   1020

caagacaagc ccgtcagcac aagagaagag ctcaggcaag gatcagcagc aaggatgtca   1080

tgaagaagat cgccaactgc agtaagatac atcttagtac caagctcctt gcagtggact   1140

tcccagagca ctttgtgaaa tccatctcct gccagatctg tgaacacatt ctggctgacc   1200

ctgtggagac caactgtaag catgtctttt gccgggtctg cattctcaga tgcctcaaag   1260

tcatgggcag ctattgtccc tcttgccgat atccatgctt ccctactgac ctggagagtc   1320

cagtgaagtc ctttctgagc gtcttgaatt ccctgatggt gaaatgtcca gcaaaagagt   1380

gcaatgagga ggtcagtttg gaaaaatata atcaccacat ctcaagtcac aaggaatcaa   1440

aagagatttt tgtgcacatt aataaagggg gtcgagtaac gcgtgcaggc atgcaagctg   1500

gccgcaataa aatatcttta ttttcattac atctgtgtgt tggttttttg tgtgaatcgt   1560

aactaacata cgctctccat caaaacaaaa cgaaacaaaa caaactagca aaataggctg   1620

tccccagtgc aagtgcaggt gccagaacat ttctctatcg aaggatctgc gatcgctccg   1680

gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg   1740

tcggcaattg aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg   1800

tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg   1860

ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac acagctgaag cttcgagggg   1920

ctcgcatctc tccttcacgc gcccgccgcc ctacctgagg ccgccatcca cgccggttga   1980

gtcgcgttct gccgcctccc gcctgtggtg cctcctgaac tgcgtccgcc gtctaggtaa   2040

gtttaaagct caggtcgaga ccgggccttt gtccggcgct cccttggagc ctacctagac   2100

tcagccggct ctccacgctt tgcctgaccc tgcttgctca actctacgtc tttgtttcgt   2160

tttctgttct gcgccgttac agatccaagc tgtgaccggc gcctacgtaa gtgatatcta   2220

ctagatttat caaaaagagt gttgacttgt gagcgctcac aattgatact tagattcatc   2280

gagagggaca cgtcgactac taaccttctt ctctttccta cagctgagat caccggcgaa   2340

ggagggccac catggcttct taccctggac accagcatgc ttctgccttt gaccaggctg   2400

ccagatccag gggccactcc aacaggagaa ctgccctaag acccagaaga cagcaggaag   2460

ccactgaggt gaggcctgag cagaagatgc caaccctgct gagggtgtac attgatggac   2520

ctcatggcat gggcaagacc accaccactc aactgctggt ggcactgggc tccagggatg   2580

acattgtgta tgtgcctgag ccaatgacct actggagagt gctaggagcc tctgagacca   2640

ttgccaacat ctacaccacc cagcacaggc tggaccaggg agaaatctct gctggagatg   2700

ctgctgtggt gatgacctct gcccagatca caatgggaat gccctatgct gtgactgatg   2760

ctgttctggc tcctcacatt ggaggagagg ctggctcttc tcatgcccct ccacctgccc   2820

tgaccctgat ctttgacaga caccccattg cagccctgct gtgctaccca gcagcaaggt   2880

acctcatggg ctccatgacc ccacaggctg tgctggcttt tgtggccctg atccctccaa   2940

ccctccctgg caccaacatt gttctgggag cactgcctga agacagacac attgacaggc   3000

tggcaaagag gcagagacct ggagagagac tggacctggc catgctggct gcaatcagaa   3060

gggtgtatgg actgctggca aacactgtga gatacctcca gtgtggaggc tcttggagag   3120

aggactgggg acagctctct ggaacagcag tgccccctca aggagctgag ccccagtcca   3180

atgctggtcc aagaccccac attggggaca ccctgttcac cctgttcaga gcccctgagc   3240

tgctggctcc caatggagac ctgtacaatg tgtttgcctg ggctctggat gttctagcca   3300

agaggctgag gtccatgcat gtgttcatcc tggactatga ccagtcccct gctggatgca   3360

gagatgctct gctgcaacta acctctggca tggtgcagac ccatgtgacc acccctggca   3420

gcatccccac catctgtgac ctagccagaa cctttgccag ggagatggga gaggccaact   3480

aaacctgagc tagctcgaca tgataagata cattgatgag tttggacaaa ccacaactag   3540

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtgaa   3600

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac   3660

aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc   3720

aagtaaaacc tctacaaatg tggtagatca tttagcttgg cgtaatcatg gtcatagctg   3780

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata   3840

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca   3900

ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc   3960

gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg   4020

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta   4080

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc   4140

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag   4200

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac   4260

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc   4320

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt   4380

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc   4440

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga   4500

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta   4560

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta   4620

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga   4680

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg   4740

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag   4800

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc   4860

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact   4920

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt   4980

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta   5040

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta   5100

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc   5160

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat   5220

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt   5280

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg   5340

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca   5400

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta   5460

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg   5520

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact   5580

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg   5640

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt   5700

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga   5760

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc   5820

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa   5880

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt   5940

attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg tctcgcgcgt   6000

ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt   6060

ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg   6120

tgtcggggct ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatatg   6180

cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ccaatattaa   6240

acttgatgag ctctagagat ggtcatgcat tttaaaaaga attactcaaa atattgtctt   6300

ggaataccag agagcaagtg ctttaagtat aggctgggaa gtaaaatgct aaaggaatga   6360

gaaggcattt ggggttgagt tcaacctaag aggcagggga gccacaggga aagacctagc   6420

acctgccaca gaagagaatt aggaagcaga attgaactat aagcaatttt gaggtgttcg   6480

ttgggctgca gttgaaatat tttttgaggt taatgagaca tttgaaatgg ccgtgtattg   6540

tttaactctt gcatagtcct gcatagggaa caatctaata ggatttctct gtgaatcaag   6600

tcttagaaat ttgcttttaa tttttatgaa aaacgcccat ttctttgttt ttgagacaga   6660

gtcctgctct gtcatccagg ctgggttgca gtggcgtgat cttggcccac tgcaatctct   6720

gcctcctggg ttcaggcaat tttcctgtct cagcctcccg agtagctggg atttcaagtg   6780

cctgccacca tgcccggcta aatttttttg tatttttggt acagatggag tatcaccatg   6840

ttggccaggc tggtctcgaa ctcctgacct caagtgattc accagccttg acctcccaaa   6900

gtgttgggat cacaggcatg agccactgtg cctgtgcccc aaaacaccaa tttctgatgt   6960

gtgatgcatg taagatagaa caaacttcag taaagcgggg acttgaaaag aggctttggt   7020

aacagctgtc agcattaacc cttgcccctc cgtacctcct aatcccaccc ctgctcaaag   7080

tatgttcatc tgagaatttg tctccataac tatgtgacta taaaaattct catcgatttt   7140

gttagttgat caattgaggg aaaaacatat gttacttgat ataactggtg ggtcaaaaga   7200

attaacccag gcaaatttga gataggtgga tgggatgatg gattgaaaat acagctgctc   7260

tctttccaat catgtactaa gtaatttggg aaagattgat ctaattgggt ctagagagta   7320

cacttcacat ggcattgttt gacttttttt ctgcatcgct agcgatctgt gcattacaac   7380

tcaaatcagt cgggtttcct ggcatatgta attgccaatg ttttttacca gaagagaaac   7440

attactccca cctcttctta ttatgttaca aactatagtg ctaatgacca tcgaccaaca   7500

gtgactttca ggatgacctg tgtgagtttt atctgaaacc atgtgaattt ttcatcttaa   7560

aagtccctta gaatctcagt ctatgtacac tcaggtttgt tgcaggttta gagttccgtg   7620

ttttttgttt ctaatgtaga cacagcctta taatttacaa cagcattcac taattaaaat   7680

tgtaagcata attactatcc acgatactta ttattagttt gcattcataa agctcaaaat   7740

tcacttcatc ctttcaagta gtgaataatt agtttctttg ggtttgcagc tttatcatcc   7800

ttttatgacc catttggaag aaataaacaa ccaaccccct ggaagactgc tttaaaaagc   7860

tggaaataca ttgtccagct agtacaatga ggctaataca atgtggaaaa tattactttt   7920

ctttgatttt agtagcctgt ttatctttac atttactgaa caaataacta ttgagcacct   7980

aatgtatact gggacccttg gggaggcaaa gatgaatcaa agattctgtc cttaaagacc   8040

ttaagttaag acgcgttgac attgattatt gactagttat taatagtaat caattacggg   8100

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc   8160

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat   8220

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc   8280

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga   8340

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg   8400

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat   8460

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt   8520

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc   8580

cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc   8640

tccccgggag cttgtatatc cattttcgga tctgatcaag agacaggatg aggatcgttt   8700

cgcatgattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt ggagaggcta   8760

ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt gttccggctg   8820

tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa   8880

ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct   8940

gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga agtgccgggg   9000

caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat ggctgatgca   9060

atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca agcgaaacat   9120

cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga tgatctggac   9180

gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc gcgcatgccc   9240

gacggcgagg atctcgtcgt gacccatggc gatgcctgct tgccgaatat catggtggaa   9300

aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga ccgctatcag   9360

gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg ggctgaccgc   9420

ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt   9480

cttgacgagt tcttctgatt aattaacagg actgaccgtg ctacgagatt tcgattccac   9540

cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat   9600

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc   9660

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc   9720

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc   9780

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg   9840

ttatccgctc acaattccac acaacataca ggatccacta gtaacggccg ccagtgtgct   9900

ggaattccga ggtcgacggt atcgataagg gcgcgcctgc ggcaagggag ttgcgggcgc   9960

acaggtaagg cgcgggaccg ggaagggggc ggcgccccgg gatcggtcta gggcggcgga  10020

ggctgccggg gcgggggtgt gtctgggtgt ggccccggcg cgcgcggggt cctgagggag  10080

gggctcgcca agggggcggg cccgcgagct cgacagcccc gagccaaagg ggcggaaggt  10140

cgccgagtgc tgggagggga ggtggggcag cgactgagcg ccgcaggagc tggctgcaac  10200

ccagacgcgg cccgggagcg tcgggtatga gctaacgggg cgggggtgcg gggaacgagc  10260

ccagtcaagg agcagcacct acctccgggg gtggaaatgg gccggaatgg gccggaacac  10320

cgtcccggaa gtgaaacccc ccgccccctc ctccgcagcg agcgacgtgc cggaaggaaa  10380

tcagtcaccc tccccccgcc cctcccccca gcactttcct tgcaggagcc ccctcccctc  10440

agcctgtact cctcagggag gcggagggcg ggcctatcgt gcccgcggca actccgccct  10500

ccgggtctcg ggggcgtggc cagagggaaa gttttgtggg cctgaagaag gtggggcttg  10560

aggaggagtc tgagggcgtg tgaggggcgg ggtttaagtg gacgcagcaa gcagctttgc  10620

gtcttgacgt cacgaagacc ttatatactc gactcagccg ccatctcagc ctttcggagc  10680

tgtgcggt  							   10688 	

<210>  52
<211>  11328
<212>  DNA
<213>  Artificial

<220>
<223>  pIM-RAG1-TagGFP2

<400>  52
atgagcgggg gcgaggagct gttcgccggc atcgtgcccg tgctgatcga gctggacggc     60

gacgtgcacg gccacaagtt cagcgtgcgc ggcgagggcg agggcgacgc cgactacggc    120

aagctggaga tcaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctg    180

gtgaccaccc tctgctacgg catccagtgc ttcgcccgct accccgagca catgaagatg    240

aacgacttct tcaagagcgc catgcccgag ggctacatcc aggagcgcac catccagttc    300

caggacgacg gcaagtacaa gacccgcggc gaggtgaagt tcgagggcga caccctggtg    360

aaccgcatcg agctgaaggg caaggacttc aaggaggacg gcaacatcct gggccacaag    420

ctggagtaca gcttcaacag ccacaacgtg tacatccgcc ccgacaaggc caacaacggc    480

ctggaggcta acttcaagac ccgccacaac atcgagggcg gcggcgtgca gctggccgac    540

cactaccaga ccaacgtgcc cctgggcgac ggccccgtgc tgatccccat caaccactac    600

ctgagcactc agaccaagat cagcaaggac cgcaacgagg cccgcgacca catggtgctc    660

ctggagtcct tcagcgcctg ctgccacacc cacggcatgg acgagctgta caggtaaccc    720

ggggagcggc cgctcgagtc tagagggccc gtttaaaccc gctgatcagc ctcgactgtg    780

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa    840

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt    900

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa    960

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc ggaaagaacg   1020

gatccgcagc ctctttccca cccaccttgg gactcagttc tgccccagat gaaattcagc   1080

acccacatat taaattttca gaatggaaat ttaagctgtt ccgggtgaga tcctttgaaa   1140

agacacctga agaagctcaa aaggaaaaga aggattcctt tgaggggaaa ccctctctgg   1200

agcaatctcc agcagtcctg gacaaggctg atggtcagaa gccagtccca actcagccat   1260

tgttaaaagc ccaccctaag ttttcgaaga aatttcacga caacgagaaa gcaagaggca   1320

aagcgatcca tcaagccaac cttcgacatc tctgccgcat ctgtgggaat tcttttagag   1380

ctgatgagca caacaggaga tatccagtcc atggtcctgt ggatggtaaa accctaggcc   1440

ttttacgaaa gaaggaaaag agagctactt cctggccgga cctcattgcc aaggttttcc   1500

ggatcgatgt gaaggcagat gttgactcga tccaccccac tgagttctgc cataactgct   1560

ggagcatcat gcacaggaag tttagcagtg ccccatgtga ggtttacttc ccgaggaacg   1620

tgaccatgga gtggcacccc cacacaccat cctgtgacat ctgcaacact gcccgtcggg   1680

gactcaagag gaagagtctt cagccaaact tgcagctcag caaaaaactc aaaactgtgc   1740

ttgaccaagc aagacaagcc cgtcagcaca agagaagagc tcaggcaagg atcagcagca   1800

aggatgtcat gaagaagatc gccaactgca gtaagataca tcttagtacc aagctccttg   1860

cagtggactt cccagagcac tttgtgaaat ccatctcctg ccagatctgt gaacacattc   1920

tggctgaccc tgtggagacc aactgtaagc atgtcttttg ccgggtctgc attctcagat   1980

gcctcaaagt catgggcagc tattgtccct cttgccgata tccatgcttc cctactgacc   2040

tggagagtcc agtgaagtcc tttctgagcg tcttgaattc cctgatggtg aaatgtccag   2100

caaaagagtg caatgaggag gtcagtttgg aaaaatataa tcaccacatc tcaagtcaca   2160

aggaatcaaa agagattttt gtgcacatta ataaaggggg tcgagtaacg cgtgcaggca   2220

tgcaagctgg ccgcaataaa atatctttat tttcattaca tctgtgtgtt ggttttttgt   2280

gtgaatcgta actaacatac gctctccatc aaaacaaaac gaaacaaaac aaactagcaa   2340

aataggctgt ccccagtgca agtgcaggtg ccagaacatt tctctatcga aggatctgcg   2400

atcgctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc gagaagttgg   2460

ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta aactgggaaa   2520

gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg tatataagtg   2580

cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca cagctgaagc   2640

ttcgaggggc tcgcatctct ccttcacgcg cccgccgccc tacctgaggc cgccatccac   2700

gccggttgag tcgcgttctg ccgcctcccg cctgtggtgc ctcctgaact gcgtccgccg   2760

tctaggtaag tttaaagctc aggtcgagac cgggcctttg tccggcgctc ccttggagcc   2820

tacctagact cagccggctc tccacgcttt gcctgaccct gcttgctcaa ctctacgtct   2880

ttgtttcgtt ttctgttctg cgccgttaca gatccaagct gtgaccggcg cctacgtaag   2940

tgatatctac tagatttatc aaaaagagtg ttgacttgtg agcgctcaca attgatactt   3000

agattcatcg agagggacac gtcgactact aaccttcttc tctttcctac agctgagatc   3060

accggcgaag gagggccacc atggcttctt accctggaca ccagcatgct tctgcctttg   3120

accaggctgc cagatccagg ggccactcca acaggagaac tgccctaaga cccagaagac   3180

agcaggaagc cactgaggtg aggcctgagc agaagatgcc aaccctgctg agggtgtaca   3240

ttgatggacc tcatggcatg ggcaagacca ccaccactca actgctggtg gcactgggct   3300

ccagggatga cattgtgtat gtgcctgagc caatgaccta ctggagagtg ctaggagcct   3360

ctgagaccat tgccaacatc tacaccaccc agcacaggct ggaccaggga gaaatctctg   3420

ctggagatgc tgctgtggtg atgacctctg cccagatcac aatgggaatg ccctatgctg   3480

tgactgatgc tgttctggct cctcacattg gaggagaggc tggctcttct catgcccctc   3540

cacctgccct gaccctgatc tttgacagac accccattgc agccctgctg tgctacccag   3600

cagcaaggta cctcatgggc tccatgaccc cacaggctgt gctggctttt gtggccctga   3660

tccctccaac cctccctggc accaacattg ttctgggagc actgcctgaa gacagacaca   3720

ttgacaggct ggcaaagagg cagagacctg gagagagact ggacctggcc atgctggctg   3780

caatcagaag ggtgtatgga ctgctggcaa acactgtgag atacctccag tgtggaggct   3840

cttggagaga ggactgggga cagctctctg gaacagcagt gccccctcaa ggagctgagc   3900

cccagtccaa tgctggtcca agaccccaca ttggggacac cctgttcacc ctgttcagag   3960

cccctgagct gctggctccc aatggagacc tgtacaatgt gtttgcctgg gctctggatg   4020

ttctagccaa gaggctgagg tccatgcatg tgttcatcct ggactatgac cagtcccctg   4080

ctggatgcag agatgctctg ctgcaactaa cctctggcat ggtgcagacc catgtgacca   4140

cccctggcag catccccacc atctgtgacc tagccagaac ctttgccagg gagatgggag   4200

aggccaacta aacctgagct agctcgacat gataagatac attgatgagt ttggacaaac   4260

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt   4320

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa   4380

gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt gtgggaggtt   4440

ttttaaagca agtaaaacct ctacaaatgt ggtagatcca tttttggcgt aatcatggtc   4500

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg   4560

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt   4620

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg   4680

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga   4740

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat   4800

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca   4860

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc   4920

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata   4980

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc   5040

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc   5100

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga   5160

cccccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc   5220

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag   5280

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag   5340

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag   5400

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca   5460

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga   5520

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat   5580

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga   5640

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg   5700

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga   5760

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc   5820

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac   5880

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc   5940

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc   6000

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc   6060

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt   6120

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc   6180

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg   6240

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag   6300

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat   6360

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc   6420

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa   6480

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta   6540

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa   6600

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga   6660

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct   6720

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac   6780

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt   6840

tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca   6900

ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcaggcgcca   6960

atattaaact tgatgagctc tagagatggt catgcatttt aaaaagaatt actcaaaata   7020

ttgtcttgga ataccagaga gcaagtgctt taagtatagg ctgggaagta aaatgctaaa   7080

ggaatgagaa ggcatttggg gttgagttca acctaagagg caggggagcc acagggaaag   7140

acctagcacc tgccacagaa gagaattagg aagcagaatt gaactataag caattttgag   7200

gtgttcgttg ggctgcagtt gaaatatttt ttgaggttaa tgagacattt gaaatggccg   7260

tgtattgttt aactcttgca tagtcctgca tagggaacaa tctaatagga tttctctgtg   7320

aatcaagtct tagaaatttg cttttaattt ttatgaaaaa cgcccatttc tttgtttttg   7380

agacagagtc ctgctctgtc atccaggctg ggttgcagtg gcgtgatctt ggcccactgc   7440

aatctctgcc tcctgggttc aggcaatttt cctgtctcag cctcccgagt agctgggatt   7500

tcaagtgcct gccaccatgc ccggctaaat ttttttgtat ttttggtaca gatggagtat   7560

caccatgttg gccaggctgg tctcgaactc ctgacctcaa gtgattcacc agccttgacc   7620

tcccaaagtg ttgggatcac aggcatgagc cactgtgcct gtgccccaaa acaccaattt   7680

ctgatgtgtg atgcatgtaa gatagaacaa acttcagtaa agcggggact tgaaaagagg   7740

ctttggtaac agctgtcagc attaaccctt gcccctccgt acctcctaat cccacccctg   7800

ctcaaagtat gttcatctga gaatttgtct ccataactat gtgactataa aaattctcat   7860

cgattttgtt agttgatcaa ttgagggaaa aacatatgtt acttgatata actggtgggt   7920

caaaagaatt aacccaggca aatttgagat aggtggatgg gatgatggat tgaaaataca   7980

gctgctctct ttccaatcat gtactaagta atttgggaaa gattgatcta attgggtcta   8040

gagagtacac ttcacatggc attgtttgac tttttttctg catcgctagc gatctgtgca   8100

ttacaactca aatcagtcgg gtttcctggc atatgtaatt gccaatgttt tttaccagaa   8160

gagaaacatt actcccacct cttcttatta tgttacaaac tatagtgcta atgaccatcg   8220

accaacagtg actttcagga tgacctgtgt gagttttatc tgaaaccatg tgaatttttc   8280

atcttaaaag tcccttagaa tctcagtcta tgtacactca ggtttgttgc aggtttagag   8340

ttccgtgttt tttgtttcta atgtagacac agccttataa tttacaacag cattcactaa   8400

ttaaaattgt aagcataatt actatccacg atacttatta ttagtttgca ttcataaagc   8460

tcaaaattca cttcatcctt tcaagtagtg aataattagt ttctttgggt ttgcagcttt   8520

atcatccttt tatgacccat ttggaagaaa taaacaacca accccctgga agactgcttt   8580

aaaaagctgg aaatacattg tccagctagt acaatgaggc taatacaatg tggaaaatat   8640

tacttttctt tgattttagt agcctgttta tctttacatt tactgaacaa ataactattg   8700

agcacctaat gtatactggg acccttgggg aggcaaagat gaatcaaaga ttctgtcctt   8760

aaagacctta agacgcgttg acattgatta ttgactagtt attaatagta atcaattacg   8820

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc   8880

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc   8940

atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact   9000

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat   9060

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact   9120

tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac   9180

atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac   9240

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac   9300

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga   9360

gctccccggg agcttgtata tccattttcg gatctgatca agagacagga tgaggatcgt   9420

ttcgcatgat tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc   9480

tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc   9540

tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg   9600

aactgcagga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag   9660

ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg   9720

ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg   9780

caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac   9840

atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg   9900

acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc   9960

ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg  10020

aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc  10080

aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc  10140

gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc  10200

ttcttgacga gttcttctga ttaattaaca ggactgaccg tgctacgaga tttcgattcc  10260

accgccgcct tctatgaaag gttgggcttc ggaatcgttt tccgggacgc cggctggatg  10320

atcctccagc gcggggatct catgctggag ttcttcgccc accccaactt gtttattgca  10380

gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt  10440

tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgtata  10500

ccgtcgacct ctagctagag cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat  10560

tgttatccgc tcacaattcc acacaacata caggatccac tagcgatgta cgggccagat  10620

atacgcgttg acattgatta ttgactagtt attaatagta atcaattacg gggtcattag  10680

ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct  10740

gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc  10800

caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg  10860

cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat  10920

ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca  10980

tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc  11040

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga  11100

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat  11160

tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctctggc  11220

taactagaga acccactgct tactggctta tcgaaattaa tacgactcac tatagggaga  11280

cccaagctgg ctagccttag gcgcgcctcg cgagtttaaa ccgccacc               11328

<210>  53
<211>  12507
<212>  DNA
<213>  Artificial

<220>
<223> pIM-RAG1-EF1-TagGFP

<400>  53
atgagcgggg gcgaggagct gttcgccggc atcgtgcccg tgctgatcga gctggacggc     60

gacgtgcacg gccacaagtt cagcgtgcgc ggcgagggcg agggcgacgc cgactacggc    120

aagctggaga tcaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctg    180

gtgaccaccc tctgctacgg catccagtgc ttcgcccgct accccgagca catgaagatg    240

aacgacttct tcaagagcgc catgcccgag ggctacatcc aggagcgcac catccagttc    300

caggacgacg gcaagtacaa gacccgcggc gaggtgaagt tcgagggcga caccctggtg    360

aaccgcatcg agctgaaggg caaggacttc aaggaggacg gcaacatcct gggccacaag    420

ctggagtaca gcttcaacag ccacaacgtg tacatccgcc ccgacaaggc caacaacggc    480

ctggaggcta acttcaagac ccgccacaac atcgagggcg gcggcgtgca gctggccgac    540

cactaccaga ccaacgtgcc cctgggcgac ggccccgtgc tgatccccat caaccactac    600

ctgagcactc agaccaagat cagcaaggac cgcaacgagg cccgcgacca catggtgctc    660

ctggagtcct tcagcgcctg ctgccacacc cacggcatgg acgagctgta caggtaaccc    720

ggggagcggc cgcggagctc caggaattct gcagatcgac tgtgccttct agttgccagc    780

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg    840

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc    900

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg    960

ctggggatgc ggtgggctct atggatccgc agcctctttc ccacccacct tgggactcag   1020

ttctgcccca gatgaaattc agcacccaca tattaaattt tcagaatgga aatttaagct   1080

gttccgggtg agatcctttg aaaagacacc tgaagaagct caaaaggaaa agaaggattc   1140

ctttgagggg aaaccctctc tggagcaatc tccagcagtc ctggacaagg ctgatggtca   1200

gaagccagtc ccaactcagc cattgttaaa agcccaccct aagttttcga agaaatttca   1260

cgacaacgag aaagcaagag gcaaagcgat ccatcaagcc aaccttcgac atctctgccg   1320

catctgtggg aattctttta gagctgatga gcacaacagg agatatccag tccatggtcc   1380

tgtggatggt aaaaccctag gccttttacg aaagaaggaa aagagagcta cttcctggcc   1440

ggacctcatt gccaaggttt tccggatcga tgtgaaggca gatgttgact cgatccaccc   1500

cactgagttc tgccataact gctggagcat catgcacagg aagtttagca gtgccccatg   1560

tgaggtttac ttcccgagga acgtgaccat ggagtggcac ccccacacac catcctgtga   1620

catctgcaac actgcccgtc ggggactcaa gaggaagagt cttcagccaa acttgcagct   1680

cagcaaaaaa ctcaaaactg tgcttgacca agcaagacaa gcccgtcagc acaagagaag   1740

agctcaggca aggatcagca gcaaggatgt catgaagaag atcgccaact gcagtaagat   1800

acatcttagt accaagctcc ttgcagtgga cttcccagag cactttgtga aatccatctc   1860

ctgccagatc tgtgaacaca ttctggctga ccctgtggag accaactgta agcatgtctt   1920

ttgccgggtc tgcattctca gatgcctcaa agtcatgggc agctattgtc cctcttgccg   1980

atatccatgc ttccctactg acctggagag tccagtgaag tcctttctga gcgtcttgaa   2040

ttccctgatg gtgaaatgtc cagcaaaaga gtgcaatgag gaggtcagtt tggaaaaata   2100

taatcaccac atctcaagtc acaaggaatc aaaagagatt tttgtgcaca ttaataaagg   2160

gggtcgagta acgcgtgcag gcatgcaagc tggccgcaat aaaatatctt tattttcatt   2220

acatctgtgt gttggttttt tgtgtgaatc gtaactaaca tacgctctcc atcaaaacaa   2280

aacgaaacaa aacaaactag caaaataggc tgtccccagt gcaagtgcag gtgccagaac   2340

atttctctat cgaaggatct gcgatcgctc cggtgcccgt cagtgggcag agcgcacatc   2400

gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag   2460

gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg   2520

tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt   2580

tgccgccaga acacagctga agcttcgagg ggctcgcatc tctccttcac gcgcccgccg   2640

ccctacctga ggccgccatc cacgccggtt gagtcgcgtt ctgccgcctc ccgcctgtgg   2700

tgcctcctga actgcgtccg ccgtctaggt aagtttaaag ctcaggtcga gaccgggcct   2760

ttgtccggcg ctcccttgga gcctacctag actcagccgg ctctccacgc tttgcctgac   2820

cctgcttgct caactctacg tctttgtttc gttttctgtt ctgcgccgtt acagatccaa   2880

gctgtgaccg gcgcctacgt aagtgatatc tactagattt atcaaaaaga gtgttgactt   2940

gtgagcgctc acaattgata cttagattca tcgagaggga cacgtcgact actaaccttc   3000

ttctctttcc tacagctgag atcaccggcg aaggagggcc accatggctt cttaccctgg   3060

acaccagcat gcttctgcct ttgaccaggc tgccagatcc aggggccact ccaacaggag   3120

aactgcccta agacccagaa gacagcagga agccactgag gtgaggcctg agcagaagat   3180

gccaaccctg ctgagggtgt acattgatgg acctcatggc atgggcaaga ccaccaccac   3240

tcaactgctg gtggcactgg gctccaggga tgacattgtg tatgtgcctg agccaatgac   3300

ctactggaga gtgctaggag cctctgagac cattgccaac atctacacca cccagcacag   3360

gctggaccag ggagaaatct ctgctggaga tgctgctgtg gtgatgacct ctgcccagat   3420

cacaatggga atgccctatg ctgtgactga tgctgttctg gctcctcaca ttggaggaga   3480

ggctggctct tctcatgccc ctccacctgc cctgaccctg atctttgaca gacaccccat   3540

tgcagccctg ctgtgctacc cagcagcaag gtacctcatg ggctccatga ccccacaggc   3600

tgtgctggct tttgtggccc tgatccctcc aaccctccct ggcaccaaca ttgttctggg   3660

agcactgcct gaagacagac acattgacag gctggcaaag aggcagagac ctggagagag   3720

actggacctg gccatgctgg ctgcaatcag aagggtgtat ggactgctgg caaacactgt   3780

gagatacctc cagtgtggag gctcttggag agaggactgg ggacagctct ctggaacagc   3840

agtgccccct caaggagctg agccccagtc caatgctggt ccaagacccc acattgggga   3900

caccctgttc accctgttca gagcccctga gctgctggct cccaatggag acctgtacaa   3960

tgtgtttgcc tgggctctgg atgttctagc caagaggctg aggtccatgc atgtgttcat   4020

cctggactat gaccagtccc ctgctggatg cagagatgct ctgctgcaac taacctctgg   4080

catggtgcag acccatgtga ccacccctgg cagcatcccc accatctgtg acctagccag   4140

aacctttgcc agggagatgg gagaggccaa ctaaacctga gctagctcga catgataaga   4200

tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt   4260

gaaatttgtg atgctattgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa   4320

ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg   4380

ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtagat   4440

catttagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca   4500

caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag   4560

tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt   4620

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc   4680

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg   4740

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa   4800

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg   4860

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga   4920

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg   4980

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg   5040

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc   5100

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg   5160

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca   5220

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt   5280

ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag   5340

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg   5400

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc   5460

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt   5520

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt   5580

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca   5640

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg   5700

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac   5760

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg   5820

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc   5880

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta   5940

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac   6000

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc   6060

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac   6120

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact   6180

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa   6240

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt   6300

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca   6360

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa   6420

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac   6480

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg   6540

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc   6600

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata   6660

ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac   6720

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag   6780

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat   6840

cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa   6900

ggagaaaata ccgcatcagg cgccaatatt aaacttgatg agctctagag atggtcatgc   6960

attttaaaaa gaattactca aaatattgtc ttggaatacc agagagcaag tgctttaagt   7020

ataggctggg aagtaaaatg ctaaaggaat gagaaggcat ttggggttga gttcaaccta   7080

agaggcaggg gagccacagg gaaagaccta gcacctgcca cagaagagaa ttaggaagca   7140

gaattgaact ataagcaatt ttgaggtgtt cgttgggctg cagttgaaat attttttgag   7200

gttaatgaga catttgaaat ggccgtgtat tgtttaactc ttgcatagtc ctgcataggg   7260

aacaatctaa taggatttct ctgtgaatca agtcttagaa atttgctttt aatttttatg   7320

aaaaacgccc atttctttgt ttttgagaca gagtcctgct ctgtcatcca ggctgggttg   7380

cagtggcgtg atcttggccc actgcaatct ctgcctcctg ggttcaggca attttcctgt   7440

ctcagcctcc cgagtagctg ggatttcaag tgcctgccac catgcccggc taaatttttt   7500

tgtatttttg gtacagatgg agtatcacca tgttggccag gctggtctcg aactcctgac   7560

ctcaagtgat tcaccagcct tgacctccca aagtgttggg atcacaggca tgagccactg   7620

tgcctgtgcc ccaaaacacc aatttctgat gtgtgatgca tgtaagatag aacaaacttc   7680

agtaaagcgg ggacttgaaa agaggctttg gtaacagctg tcagcattaa cccttgcccc   7740

tccgtacctc ctaatcccac ccctgctcaa agtatgttca tctgagaatt tgtctccata   7800

actatgtgac tataaaaatt ctcatcgatt ttgttagttg atcaattgag ggaaaaacat   7860

atgttacttg atataactgg tgggtcaaaa gaattaaccc aggcaaattt gagataggtg   7920

gatgggatga tggattgaaa atacagctgc tctctttcca atcatgtact aagtaatttg   7980

ggaaagattg atctaattgg gtctagagag tacacttcac atggcattgt ttgacttttt   8040

ttctgcatcg ctagcgatct gtgcattaca actcaaatca gtcgggtttc ctggcatatg   8100

taattgccaa tgttttttac cagaagagaa acattactcc cacctcttct tattatgtta   8160

caaactatag tgctaatgac catcgaccaa cagtgacttt caggatgacc tgtgtgagtt   8220

ttatctgaaa ccatgtgaat ttttcatctt aaaagtccct tagaatctca gtctatgtac   8280

actcaggttt gttgcaggtt tagagttccg tgttttttgt ttctaatgta gacacagcct   8340

tataatttac aacagcattc actaattaaa attgtaagca taattactat ccacgatact   8400

tattattagt ttgcattcat aaagctcaaa attcacttca tcctttcaag tagtgaataa   8460

ttagtttctt tgggtttgca gctttatcat ccttttatga cccatttgga agaaataaac   8520

aaccaacccc ctggaagact gctttaaaaa gctggaaata cattgtccag ctagtacaat   8580

gaggctaata caatgtggaa aatattactt ttctttgatt ttagtagcct gtttatcttt   8640

acatttactg aacaaataac tattgagcac ctaatgtata ctgggaccct tggggaggca   8700

aagatgaatc aaagattctg tccttaaaga ccttaagtta agacgcgttg acattgatta   8760

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag   8820

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc   8880

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga   8940

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat   9000

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc   9060

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct   9120

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca   9180

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat   9240

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg   9300

cgtgtacggt gggaggtcta tataagcaga gctccccggg agcttgtata tccattttcg   9360

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg   9420

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa   9480

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg   9540

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt   9600

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa   9660

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc   9720

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg   9780

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg   9840

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg   9900

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg   9960

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact  10020

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg  10080

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc  10140

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga ttaattaaca  10200

ggactgaccg tgctacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc  10260

ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag  10320

ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata aagcaatagc  10380

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa  10440

ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag cttggcgtaa  10500

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata  10560

caggatccac tagtaacggc cgccagtgtg ctggaattcc gaggtcgacg gtatcgataa  10620

gggcgcgcca aagctaactg taggactgag tctattctaa actgaaagcc tggacatctg  10680

gagtaccagg gggagatgac gtgttacggg cttccataaa agcagctggc tttgaatgga  10740

aggagccaag aggccagcac aggagcggat tcgtcgcttt cacggccatc gagccgaacc  10800

tctcgcaagt ccgtgagccg ttaaggaggc ccccagtccc gacccttcgc cccaagcccc  10860

tcggggtccc cgggcctggt actccttgcc acacgggagg ggcgcggaag ccggggcgga  10920

ggaggagcca accccgggct gggctgagac ccgcagagga agacgctcta gggatttgtc  10980

ccggactagc gagatggcaa ggctgaggac gggaggctga ttgagaggcg aaggtacacc  11040

ctaatctcaa tacaaccttt ggagctaagc cagcaatggt agagggaaga ttctgcacgt  11100

cccttccagg cggcctcccc gtcaccaccc cccccaaccc gccccgaccg gagctgagag  11160

taattcatac aaaaggactc gcccctgcct tggggaatcc cagggaccgt cgttaaactc  11220

ccactaacgt agaacccaga gatcgctgcg ttcccgcccc ctcacccgcc cgctctcgtc  11280

atcactgagg tggagaagag catgcgtgag gctccggtgc ccgtcagtgg gcagagcgca  11340

catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga  11400

gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg  11460

agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg  11520

ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta  11580

cgggttatgg cccttgcgtg ccttgaatta cttccacgcc cctggctgca gtacgtgatt  11640

cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg cgcttaagga  11700

gccccttcgc ctcgtgcttg agttgaggcc tggcttgggc gctggggccg ccgcgtgcga  11760

atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc catttaaaat  11820

ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa tgcgggccaa  11880

gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc  11940

cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat cggacggggg  12000

tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg tatcgccccg  12060

ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag atggccgctt  12120

cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt  12180

gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc  12240

acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg gagtacgtcg  12300

tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga gtgggtggag  12360

actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc cctttttgag  12420

tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt tcttccattt  12480

caggtgtcgt gggtttaaac cgccacc                                      12507

<210>  54
<211>  11395
<212>  DNA
<213>  Artificial

<220>
<223> pIM-RAG1-GAS5-TagGFP2

<400>  54
atgagcgggg gcgaggagct gttcgccggc atcgtgcccg tgctgatcga gctggacggc     60

gacgtgcacg gccacaagtt cagcgtgcgc ggcgagggcg agggcgacgc cgactacggc    120

aagctggaga tcaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctg    180

gtgaccaccc tctgctacgg catccagtgc ttcgcccgct accccgagca catgaagatg    240

aacgacttct tcaagagcgc catgcccgag ggctacatcc aggagcgcac catccagttc    300

caggacgacg gcaagtacaa gacccgcggc gaggtgaagt tcgagggcga caccctggtg    360

aaccgcatcg agctgaaggg caaggacttc aaggaggacg gcaacatcct gggccacaag    420

ctggagtaca gcttcaacag ccacaacgtg tacatccgcc ccgacaaggc caacaacggc    480

ctggaggcta acttcaagac ccgccacaac atcgagggcg gcggcgtgca gctggccgac    540

cactaccaga ccaacgtgcc cctgggcgac ggccccgtgc tgatccccat caaccactac    600

ctgagcactc agaccaagat cagcaaggac cgcaacgagg cccgcgacca catggtgctc    660

ctggagtcct tcagcgcctg ctgccacacc cacggcatgg acgagctgta caggtaaccc    720

ggggagcggc cgcggagctc caggaattct gcagatcgac tgtgccttct agttgccagc    780

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg    840

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc    900

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg    960

ctggggatgc ggtgggctct atggatccgc agcctctttc ccacccacct tgggactcag   1020

ttctgcccca gatgaaattc agcacccaca tattaaattt tcagaatgga aatttaagct   1080

gttccgggtg agatcctttg aaaagacacc tgaagaagct caaaaggaaa agaaggattc   1140

ctttgagggg aaaccctctc tggagcaatc tccagcagtc ctggacaagg ctgatggtca   1200

gaagccagtc ccaactcagc cattgttaaa agcccaccct aagttttcga agaaatttca   1260

cgacaacgag aaagcaagag gcaaagcgat ccatcaagcc aaccttcgac atctctgccg   1320

catctgtggg aattctttta gagctgatga gcacaacagg agatatccag tccatggtcc   1380

tgtggatggt aaaaccctag gccttttacg aaagaaggaa aagagagcta cttcctggcc   1440

ggacctcatt gccaaggttt tccggatcga tgtgaaggca gatgttgact cgatccaccc   1500

cactgagttc tgccataact gctggagcat catgcacagg aagtttagca gtgccccatg   1560

tgaggtttac ttcccgagga acgtgaccat ggagtggcac ccccacacac catcctgtga   1620

catctgcaac actgcccgtc ggggactcaa gaggaagagt cttcagccaa acttgcagct   1680

cagcaaaaaa ctcaaaactg tgcttgacca agcaagacaa gcccgtcagc acaagagaag   1740

agctcaggca aggatcagca gcaaggatgt catgaagaag atcgccaact gcagtaagat   1800

acatcttagt accaagctcc ttgcagtgga cttcccagag cactttgtga aatccatctc   1860

ctgccagatc tgtgaacaca ttctggctga ccctgtggag accaactgta agcatgtctt   1920

ttgccgggtc tgcattctca gatgcctcaa agtcatgggc agctattgtc cctcttgccg   1980

atatccatgc ttccctactg acctggagag tccagtgaag tcctttctga gcgtcttgaa   2040

ttccctgatg gtgaaatgtc cagcaaaaga gtgcaatgag gaggtcagtt tggaaaaata   2100

taatcaccac atctcaagtc acaaggaatc aaaagagatt tttgtgcaca ttaataaagg   2160

gggtcgagta acgcgtgcag gcatgcaagc tggccgcaat aaaatatctt tattttcatt   2220

acatctgtgt gttggttttt tgtgtgaatc gtaactaaca tacgctctcc atcaaaacaa   2280

aacgaaacaa aacaaactag caaaataggc tgtccccagt gcaagtgcag gtgccagaac   2340

atttctctat cgaaggatct gcgatcgctc cggtgcccgt cagtgggcag agcgcacatc   2400

gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag   2460

gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg   2520

tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt   2580

tgccgccaga acacagctga agcttcgagg ggctcgcatc tctccttcac gcgcccgccg   2640

ccctacctga ggccgccatc cacgccggtt gagtcgcgtt ctgccgcctc ccgcctgtgg   2700

tgcctcctga actgcgtccg ccgtctaggt aagtttaaag ctcaggtcga gaccgggcct   2760

ttgtccggcg ctcccttgga gcctacctag actcagccgg ctctccacgc tttgcctgac   2820

cctgcttgct caactctacg tctttgtttc gttttctgtt ctgcgccgtt acagatccaa   2880

gctgtgaccg gcgcctacgt aagtgatatc tactagattt atcaaaaaga gtgttgactt   2940

gtgagcgctc acaattgata cttagattca tcgagaggga cacgtcgact actaaccttc   3000

ttctctttcc tacagctgag atcaccggcg aaggagggcc accatggctt cttaccctgg   3060

acaccagcat gcttctgcct ttgaccaggc tgccagatcc aggggccact ccaacaggag   3120

aactgcccta agacccagaa gacagcagga agccactgag gtgaggcctg agcagaagat   3180

gccaaccctg ctgagggtgt acattgatgg acctcatggc atgggcaaga ccaccaccac   3240

tcaactgctg gtggcactgg gctccaggga tgacattgtg tatgtgcctg agccaatgac   3300

ctactggaga gtgctaggag cctctgagac cattgccaac atctacacca cccagcacag   3360

gctggaccag ggagaaatct ctgctggaga tgctgctgtg gtgatgacct ctgcccagat   3420

cacaatggga atgccctatg ctgtgactga tgctgttctg gctcctcaca ttggaggaga   3480

ggctggctct tctcatgccc ctccacctgc cctgaccctg atctttgaca gacaccccat   3540

tgcagccctg ctgtgctacc cagcagcaag gtacctcatg ggctccatga ccccacaggc   3600

tgtgctggct tttgtggccc tgatccctcc aaccctccct ggcaccaaca ttgttctggg   3660

agcactgcct gaagacagac acattgacag gctggcaaag aggcagagac ctggagagag   3720

actggacctg gccatgctgg ctgcaatcag aagggtgtat ggactgctgg caaacactgt   3780

gagatacctc cagtgtggag gctcttggag agaggactgg ggacagctct ctggaacagc   3840

agtgccccct caaggagctg agccccagtc caatgctggt ccaagacccc acattgggga   3900

caccctgttc accctgttca gagcccctga gctgctggct cccaatggag acctgtacaa   3960

tgtgtttgcc tgggctctgg atgttctagc caagaggctg aggtccatgc atgtgttcat   4020

cctggactat gaccagtccc ctgctggatg cagagatgct ctgctgcaac taacctctgg   4080

catggtgcag acccatgtga ccacccctgg cagcatcccc accatctgtg acctagccag   4140

aacctttgcc agggagatgg gagaggccaa ctaaacctga gctagctcga catgataaga   4200

tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt   4260

gaaatttgtg atgctattgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa   4320

ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg   4380

ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtagat   4440

catttagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca   4500

caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag   4560

tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt   4620

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc   4680

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg   4740

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa   4800

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg   4860

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga   4920

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg   4980

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg   5040

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc   5100

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg   5160

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca   5220

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt   5280

ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag   5340

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg   5400

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc   5460

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt   5520

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt   5580

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca   5640

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg   5700

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac   5760

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg   5820

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc   5880

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta   5940

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac   6000

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc   6060

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac   6120

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact   6180

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa   6240

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt   6300

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca   6360

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa   6420

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac   6480

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg   6540

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc   6600

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata   6660

ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac   6720

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag   6780

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat   6840

cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa   6900

ggagaaaata ccgcatcagg cgccaatatt aaacttgatg agctctagag atggtcatgc   6960

attttaaaaa gaattactca aaatattgtc ttggaatacc agagagcaag tgctttaagt   7020

ataggctggg aagtaaaatg ctaaaggaat gagaaggcat ttggggttga gttcaaccta   7080

agaggcaggg gagccacagg gaaagaccta gcacctgcca cagaagagaa ttaggaagca   7140

gaattgaact ataagcaatt ttgaggtgtt cgttgggctg cagttgaaat attttttgag   7200

gttaatgaga catttgaaat ggccgtgtat tgtttaactc ttgcatagtc ctgcataggg   7260

aacaatctaa taggatttct ctgtgaatca agtcttagaa atttgctttt aatttttatg   7320

aaaaacgccc atttctttgt ttttgagaca gagtcctgct ctgtcatcca ggctgggttg   7380

cagtggcgtg atcttggccc actgcaatct ctgcctcctg ggttcaggca attttcctgt   7440

ctcagcctcc cgagtagctg ggatttcaag tgcctgccac catgcccggc taaatttttt   7500

tgtatttttg gtacagatgg agtatcacca tgttggccag gctggtctcg aactcctgac   7560

ctcaagtgat tcaccagcct tgacctccca aagtgttggg atcacaggca tgagccactg   7620

tgcctgtgcc ccaaaacacc aatttctgat gtgtgatgca tgtaagatag aacaaacttc   7680

agtaaagcgg ggacttgaaa agaggctttg gtaacagctg tcagcattaa cccttgcccc   7740

tccgtacctc ctaatcccac ccctgctcaa agtatgttca tctgagaatt tgtctccata   7800

actatgtgac tataaaaatt ctcatcgatt ttgttagttg atcaattgag ggaaaaacat   7860

atgttacttg atataactgg tgggtcaaaa gaattaaccc aggcaaattt gagataggtg   7920

gatgggatga tggattgaaa atacagctgc tctctttcca atcatgtact aagtaatttg   7980

ggaaagattg atctaattgg gtctagagag tacacttcac atggcattgt ttgacttttt   8040

ttctgcatcg ctagcgatct gtgcattaca actcaaatca gtcgggtttc ctggcatatg   8100

taattgccaa tgttttttac cagaagagaa acattactcc cacctcttct tattatgtta   8160

caaactatag tgctaatgac catcgaccaa cagtgacttt caggatgacc tgtgtgagtt   8220

ttatctgaaa ccatgtgaat ttttcatctt aaaagtccct tagaatctca gtctatgtac   8280

actcaggttt gttgcaggtt tagagttccg tgttttttgt ttctaatgta gacacagcct   8340

tataatttac aacagcattc actaattaaa attgtaagca taattactat ccacgatact   8400

tattattagt ttgcattcat aaagctcaaa attcacttca tcctttcaag tagtgaataa   8460

ttagtttctt tgggtttgca gctttatcat ccttttatga cccatttgga agaaataaac   8520

aaccaacccc ctggaagact gctttaaaaa gctggaaata cattgtccag ctagtacaat   8580

gaggctaata caatgtggaa aatattactt ttctttgatt ttagtagcct gtttatcttt   8640

acatttactg aacaaataac tattgagcac ctaatgtata ctgggaccct tggggaggca   8700

aagatgaatc aaagattctg tccttaaaga ccttaagtta agacgcgttg acattgatta   8760

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag   8820

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc   8880

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga   8940

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat   9000

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc   9060

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct   9120

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca   9180

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat   9240

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg   9300

cgtgtacggt gggaggtcta tataagcaga gctccccggg agcttgtata tccattttcg   9360

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg   9420

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa   9480

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg   9540

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt   9600

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa   9660

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc   9720

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg   9780

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg   9840

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg   9900

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg   9960

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact  10020

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg  10080

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc  10140

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga ttaattaaca  10200

ggactgaccg tgctacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc  10260

ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag  10320

ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata aagcaatagc  10380

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa  10440

ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag cttggcgtaa  10500

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata  10560

caggatccac tagtaacggc cgccagtgtg ctggaattcc gaggtcgacg gtatcgataa  10620

gggcgcgcct gcggcaaggg agttgcgggc gcacaggtaa ggcgcgggac cgggaagggg  10680

gcggcgcccc gggatcggtc tagggcggcg gaggctgccg gggcgggggt gtgtctgggt  10740

gtggccccgg cgcgcgcggg gtcctgaggg aggggctcgc caagggggcg ggcccgcgag  10800

ctcgacagcc ccgagccaaa ggggcggaag gtcgccgagt gctgggaggg gaggtggggc  10860

agcgactgag cgccgcagga gctggctgca acccagacgc ggcccgggag cgtcgggtat  10920

gagctaacgg ggcgggggtg cggggaacga gcccagtcaa ggagcagcac ctacctccgg  10980

gggtggaaat gggccggaat gggccggaac accgtcccgg aagtgaaacc ccccgccccc  11040

tcctccgcag cgagcgacgt gccggaagga aatcagtcac cctccccccg cccctccccc  11100

cagcactttc cttgcaggag ccccctcccc tcagcctgta ctcctcaggg aggcggaggg  11160

cgggcctatc gtgcccgcgg caactccgcc ctccgggtct cgggggcgtg gccagaggga  11220

aagttttgtg ggcctgaaga aggtggggct tgaggaggag tctgagggcg tgtgaggggc  11280

ggggtttaag tggacgcagc aagcagcttt gcgtcttgac gtcacgaaga ccttatatac  11340

tcgactcagc cgccatctca gcctttcgga gctgtgcggt gtttaaaccg ccacc       11395

<210>  55
<211>  10872
<212>  DNA
<213>  Artificial

<220>
<223> pIM-RAG1-Hygro

<400>  55
ggcgcgccag atctgtacat tcgaagatat cttaattaag cggccgctcg agtctagagg     60

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    120

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    180

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    240

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    300

ggtgggctct atggcttctg aggcggaaag aacggatccg cagcctcttt cccacccacc    360

ttgggactca gttctgcccc agatgaaatt cagcacccac atattaaatt ttcagaatgg    420

aaatttaagc tgttccgggt gagatccttt gaaaagacac ctgaagaagc tcaaaaggaa    480

aagaaggatt cctttgaggg gaaaccctct ctggagcaat ctccagcagt cctggacaag    540

gctgatggtc agaagccagt cccaactcag ccattgttaa aagcccaccc taagttttcg    600

aagaaatttc acgacaacga gaaagcaaga ggcaaagcga tccatcaagc caaccttcga    660

catctctgcc gcatctgtgg gaattctttt agagctgatg agcacaacag gagatatcca    720

gtccatggtc ctgtggatgg taaaacccta ggccttttac gaaagaagga aaagagagct    780

acttcctggc cggacctcat tgccaaggtt ttccggatcg atgtgaaggc agatgttgac    840

tcgatccacc ccactgagtt ctgccataac tgctggagca tcatgcacag gaagtttagc    900

agtgccccat gtgaggttta cttcccgagg aacgtgacca tggagtggca cccccacaca    960

ccatcctgtg acatctgcaa cactgcccgt cggggactca agaggaagag tcttcagcca   1020

aacttgcagc tcagcaaaaa actcaaaact gtgcttgacc aagcaagaca agcccgtcag   1080

cacaagagaa gagctcaggc aaggatcagc agcaaggatg tcatgaagaa gatcgccaac   1140

tgcagtaaga tacatcttag taccaagctc cttgcagtgg acttcccaga gcactttgtg   1200

aaatccatct cctgccagat ctgtgaacac attctggctg accctgtgga gaccaactgt   1260

aagcatgtct tttgccgggt ctgcattctc agatgcctca aagtcatggg cagctattgt   1320

ccctcttgcc gatatccatg cttccctact gacctggaga gtccagtgaa gtcctttctg   1380

agcgtcttga attccctgat ggtgaaatgt ccagcaaaag agtgcaatga ggaggtcagt   1440

ttggaaaaat ataatcacca catctcaagt cacaaggaat caaaagagat ttttgtgcac   1500

attaataaag ggggtcgagt aacgcgtgca ggcatgcaag ctggccgcaa taaaatatct   1560

ttattttcat tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac atacgctctc   1620

catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag tgcaagtgca   1680

ggtgccagaa catttctcta tcgaaggatc tgcgatcgct ccggtgcccg tcagtgggca   1740

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt   1800

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt   1860

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt   1920

cgcaacgggt ttgccgccag aacacagctg aagcttcgag gggctcgcat ctctccttca   1980

cgcgcccgcc gccctacctg aggccgccat ccacgccggt tgagtcgcgt tctgccgcct   2040

cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg   2100

agaccgggcc tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg   2160

ctttgcctga ccctgcttgc tcaactctac gtctttgttt cgttttctgt tctgcgccgt   2220

tacagatcca agctgtgacc ggcgcctacg taagtgatat ctactagatt tatcaaaaag   2280

agtgttgact tgtgagcgct cacaattgat acttagattc atcgagaggg acacgtcgac   2340

tactaacctt cttctctttc ctacagctga gatcaccggc gaaggagggc caccatggct   2400

tcttaccctg gacaccagca tgcttctgcc tttgaccagg ctgccagatc caggggccac   2460

tccaacagga gaactgccct aagacccaga agacagcagg aagccactga ggtgaggcct   2520

gagcagaaga tgccaaccct gctgagggtg tacattgatg gacctcatgg catgggcaag   2580

accaccacca ctcaactgct ggtggcactg ggctccaggg atgacattgt gtatgtgcct   2640

gagccaatga cctactggag agtgctagga gcctctgaga ccattgccaa catctacacc   2700

acccagcaca ggctggacca gggagaaatc tctgctggag atgctgctgt ggtgatgacc   2760

tctgcccaga tcacaatggg aatgccctat gctgtgactg atgctgttct ggctcctcac   2820

attggaggag aggctggctc ttctcatgcc cctccacctg ccctgaccct gatctttgac   2880

agacacccca ttgcagccct gctgtgctac ccagcagcaa ggtacctcat gggctccatg   2940

accccacagg ctgtgctggc ttttgtggcc ctgatccctc caaccctccc tggcaccaac   3000

attgttctgg gagcactgcc tgaagacaga cacattgaca ggctggcaaa gaggcagaga   3060

cctggagaga gactggacct ggccatgctg gctgcaatca gaagggtgta tggactgctg   3120

gcaaacactg tgagatacct ccagtgtgga ggctcttgga gagaggactg gggacagctc   3180

tctggaacag cagtgccccc tcaaggagct gagccccagt ccaatgctgg tccaagaccc   3240

cacattgggg acaccctgtt caccctgttc agagcccctg agctgctggc tcccaatgga   3300

gacctgtaca atgtgtttgc ctgggctctg gatgttctag ccaagaggct gaggtccatg   3360

catgtgttca tcctggacta tgaccagtcc cctgctggat gcagagatgc tctgctgcaa   3420

ctaacctctg gcatggtgca gacccatgtg accacccctg gcagcatccc caccatctgt   3480

gacctagcca gaacctttgc cagggagatg ggagaggcca actaaacctg agctagctcg   3540

acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat   3600

gctttatttg tgaaatttgt gatgctattg ctttatttgt gaaatttgtg atgctattgc   3660

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt   3720

tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa   3780

atgtggtaga tccatttttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt   3840

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg   3900

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg   3960

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc   4020

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc   4080

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata   4140

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg   4200

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct   4260

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa   4320

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc   4380

tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt   4440

aggtcgttcg ctccaagctg ggctgtgtgc acgacccccc cgttcagccc gaccgctgcg   4500

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg   4560

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct   4620

tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc   4680

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg   4740

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc   4800

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt   4860

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa   4920

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat   4980

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct   5040

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg   5100

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag   5160

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta   5220

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg   5280

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg   5340

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct   5400

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta   5460

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg   5520

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc   5580

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg   5640

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga   5700

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg   5760

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat   5820

gttgaatact catactcttc ctttttcaat attattgaag catttatcag ggttattgtc   5880

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca   5940

catttccccg aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct   6000

ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa   6060

acctctgaca catgcagctc ccggagacgg tcacagcttg tctgtaagcg gatgccggga   6120

gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact   6180

atgcggcatc agagcagatt gtactgagag tgcaccatat gcggtgtgaa ataccgcaca   6240

gatgcgtaag gagaaaatac cgcatcaggc gccaatatta aacttgatga gctctagaga   6300

tggtcatgca ttttaaaaag aattactcaa aatattgtct tggaatacca gagagcaagt   6360

gctttaagta taggctggga agtaaaatgc taaaggaatg agaaggcatt tggggttgag   6420

ttcaacctaa gaggcagggg agccacaggg aaagacctag cacctgccac agaagagaat   6480

taggaagcag aattgaacta taagcaattt tgaggtgttc gttgggctgc agttgaaata   6540

ttttttgagg ttaatgagac atttgaaatg gccgtgtatt gtttaactct tgcatagtcc   6600

tgcataggga acaatctaat aggatttctc tgtgaatcaa gtcttagaaa tttgctttta   6660

atttttatga aaaacgccca tttctttgtt tttgagacag agtcctgctc tgtcatccag   6720

gctgggttgc agtggcgtga tcttggccca ctgcaatctc tgcctcctgg gttcaggcaa   6780

ttttcctgtc tcagcctccc gagtagctgg gatttcaagt gcctgccacc atgcccggct   6840

aaattttttt gtatttttgg tacagatgga gtatcaccat gttggccagg ctggtctcga   6900

actcctgacc tcaagtgatt caccagcctt gacctcccaa agtgttggga tcacaggcat   6960

gagccactgt gcctgtgccc caaaacacca atttctgatg tgtgatgcat gtaagataga   7020

acaaacttca gtaaagcggg gacttgaaaa gaggctttgg taacagctgt cagcattaac   7080

ccttgcccct ccgtacctcc taatcccacc cctgctcaaa gtatgttcat ctgagaattt   7140

gtctccataa ctatgtgact ataaaaattc tcatcgattt tgttagttga tcaattgagg   7200

gaaaaacata tgttacttga tataactggt gggtcaaaag aattaaccca ggcaaatttg   7260

agataggtgg atgggatgat ggattgaaaa tacagctgct ctctttccaa tcatgtacta   7320

agtaatttgg gaaagattga tctaattggg tctagagagt acacttcaca tggcattgtt   7380

tgactttttt tctgcatcgc tagcgatctg tgcattacaa ctcaaatcag tcgggtttcc   7440

tggcatatgt aattgccaat gttttttacc agaagagaaa cattactccc acctcttctt   7500

attatgttac aaactatagt gctaatgacc atcgaccaac agtgactttc aggatgacct   7560

gtgtgagttt tatctgaaac catgtgaatt tttcatctta aaagtccctt agaatctcag   7620

tctatgtaca ctcaggtttg ttgcaggttt agagttccgt gttttttgtt tctaatgtag   7680

acacagcctt ataatttaca acagcattca ctaattaaaa ttgtaagcat aattactatc   7740

cacgatactt attattagtt tgcattcata aagctcaaaa ttcacttcat cctttcaagt   7800

agtgaataat tagtttcttt gggtttgcag ctttatcatc cttttatgac ccatttggaa   7860

gaaataaaca accaaccccc tggaagactg ctttaaaaag ctggaaatac attgtccagc   7920

tagtacaatg aggctaatac aatgtggaaa atattacttt tctttgattt tagtagcctg   7980

tttatcttta catttactga acaaataact attgagcacc taatgtatac tgggaccctt   8040

ggggaggcaa agatgaatca aagattctgt ccttaaagac cttaagacgc gttgacattg   8100

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat   8160

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc   8220

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca   8280

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta   8340

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta   8400

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat   8460

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga   8520

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca   8580

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg   8640

taggcgtgta cggtgggagg tctatataag cagagctccc cggggatcaa gggcgaattc   8700

tgcagatggg agcttgtata tccattttcg gatctgatca gcacgtgatg aaaaagcctg   8760

aactcaccgc gacgtctgtc gagaagtttc tgatcgaaaa gttcgacagc gtctccgacc   8820

tgatgcagct ctcggagggc gaagaatctc gtgctttcag cttcgatgta ggagggcgtg   8880

gatatgtcct gcgggtaaat agctgcgccg atggtttcta caaagatcgt tatgtttatc   8940

ggcactttgc atcggccgcg ctcccgattc cggaagtgct tgacattggg gaattcagcg   9000

agagcctgac ctattgcatc tcccgccgtg cacagggtgt cacgttgcaa gacctgcctg   9060

aaaccgaact gcccgctgtt ctgcagccgg tcgcggaggc catggatgcg atcgctgcgg   9120

ccgatcttag ccagacgagc gggttcggcc cattcggacc gcaaggaatc ggtcaataca   9180

ctacatggcg tgatttcata tgcgcgattg ctgatcccca tgtgtatcac tggcaaactg   9240

tgatggacga caccgtcagt gcgtccgtcg cgcaggctct cgatgagctg atgctttggg   9300

ccgaggactg ccccgaagtc cggcacctcg tgcacgcgga tttcggctcc aacaatgtcc   9360

tgacggacaa tggccgcata acagcggtca ttgactggag cgaggcgatg ttcggggatt   9420

cccaatacga ggtcgccaac atcttcttct ggaggccgtg gttggcttgt atggagcagc   9480

agacgcgcta cttcgagcgg aggcatccgg agcttgcagg atcgccgcgg ctccgggcgt   9540

atatgctccg cattggtctt gaccaactct atcagagctt ggttgacggc aatttcgatg   9600

atgcagcttg ggcgcagggt cgatgcgacg caatcgtccg atccggagcc gggactgtcg   9660

ggcgtacaca aatcgcccgc agaagcgcgg ccgtctggac cgatggctgt gtagaagtac   9720

tcgccgatag tggaaaccga cgccccagca ctcgtccgag ggcaaaggaa tagcacgtgc   9780

tacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc   9840

gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc   9900

ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca   9960

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat  10020

cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc  10080

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca  10140

taaagtgtaa agcctacgcg aattcgccct tgcgcgcgat gtacgggcca gatatacgcg  10200

ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag  10260

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc  10320

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg  10380

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca  10440

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc  10500

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt  10560

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata  10620

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt  10680

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca  10740

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctctct ggctaactag  10800

agaacccact gcttactggc ttatcgaaat taatacgact cactataggg agacccaagc  10860

tggctagcct ta                                                      10872

<210>  56
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  DMD21 single chain meganuclease

<400>  56

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Glu Leu Thr Phe Thr Val Gly Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Thr Asp Ser Gly Ser Met Ser Ala Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Asn Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Arg Pro Asn Gln Ser Ala 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Gln Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ser Gly Ser Val Ser Asp Tyr Lys Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        

<210>  57
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  CAPNS1 single chain meganuclease

<400>  57

Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Arg Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gln Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Pro Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Arg Leu Thr Phe Tyr Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        

<210>  58
<211>  10613
<212>  DNA
<213>  Artificial

<220>
<223>  pIM.RAG1.CMV.Neo

<400>  58
ggcgcgccag atctgtacat tcgaagatat cttaattaag cggccgctcg agtctagagg     60

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    120

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    180

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    240

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    300

ggtgggctct atggcttctg aggcggaaag aacggatccg cagcctcttt cccacccacc    360

ttgggactca gttctgcccc agatgaaatt cagcacccac atattaaatt ttcagaatgg    420

aaatttaagc tgttccgggt gagatccttt gaaaagacac ctgaagaagc tcaaaaggaa    480

aagaaggatt cctttgaggg gaaaccctct ctggagcaat ctccagcagt cctggacaag    540

gctgatggtc agaagccagt cccaactcag ccattgttaa aagcccaccc taagttttcg    600

aagaaatttc acgacaacga gaaagcaaga ggcaaagcga tccatcaagc caaccttcga    660

catctctgcc gcatctgtgg gaattctttt agagctgatg agcacaacag gagatatcca    720

gtccatggtc ctgtggatgg taaaacccta ggccttttac gaaagaagga aaagagagct    780

acttcctggc cggacctcat tgccaaggtt ttccggatcg atgtgaaggc agatgttgac    840

tcgatccacc ccactgagtt ctgccataac tgctggagca tcatgcacag gaagtttagc    900

agtgccccat gtgaggttta cttcccgagg aacgtgacca tggagtggca cccccacaca    960

ccatcctgtg acatctgcaa cactgcccgt cggggactca agaggaagag tcttcagcca   1020

aacttgcagc tcagcaaaaa actcaaaact gtgcttgacc aagcaagaca agcccgtcag   1080

cacaagagaa gagctcaggc aaggatcagc agcaaggatg tcatgaagaa gatcgccaac   1140

tgcagtaaga tacatcttag taccaagctc cttgcagtgg acttcccaga gcactttgtg   1200

aaatccatct cctgccagat ctgtgaacac attctggctg accctgtgga gaccaactgt   1260

aagcatgtct tttgccgggt ctgcattctc agatgcctca aagtcatggg cagctattgt   1320

ccctcttgcc gatatccatg cttccctact gacctggaga gtccagtgaa gtcctttctg   1380

agcgtcttga attccctgat ggtgaaatgt ccagcaaaag agtgcaatga ggaggtcagt   1440

ttggaaaaat ataatcacca catctcaagt cacaaggaat caaaagagat ttttgtgcac   1500

attaataaag ggggtcgagt aacgcgtgca ggcatgcaag ctggccgcaa taaaatatct   1560

ttattttcat tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac atacgctctc   1620

catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag tgcaagtgca   1680

ggtgccagaa catttctcta tcgaaggatc tgcgatcgct ccggtgcccg tcagtgggca   1740

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt   1800

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt   1860

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt   1920

cgcaacgggt ttgccgccag aacacagctg aagcttcgag gggctcgcat ctctccttca   1980

cgcgcccgcc gccctacctg aggccgccat ccacgccggt tgagtcgcgt tctgccgcct   2040

cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg   2100

agaccgggcc tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg   2160

ctttgcctga ccctgcttgc tcaactctac gtctttgttt cgttttctgt tctgcgccgt   2220

tacagatcca agctgtgacc ggcgcctacg taagtgatat ctactagatt tatcaaaaag   2280

agtgttgact tgtgagcgct cacaattgat acttagattc atcgagaggg acacgtcgac   2340

tactaacctt cttctctttc ctacagctga gatcaccggc gaaggagggc caccatggct   2400

tcttaccctg gacaccagca tgcttctgcc tttgaccagg ctgccagatc caggggccac   2460

tccaacagga gaactgccct aagacccaga agacagcagg aagccactga ggtgaggcct   2520

gagcagaaga tgccaaccct gctgagggtg tacattgatg gacctcatgg catgggcaag   2580

accaccacca ctcaactgct ggtggcactg ggctccaggg atgacattgt gtatgtgcct   2640

gagccaatga cctactggag agtgctagga gcctctgaga ccattgccaa catctacacc   2700

acccagcaca ggctggacca gggagaaatc tctgctggag atgctgctgt ggtgatgacc   2760

tctgcccaga tcacaatggg aatgccctat gctgtgactg atgctgttct ggctcctcac   2820

attggaggag aggctggctc ttctcatgcc cctccacctg ccctgaccct gatctttgac   2880

agacacccca ttgcagccct gctgtgctac ccagcagcaa ggtacctcat gggctccatg   2940

accccacagg ctgtgctggc ttttgtggcc ctgatccctc caaccctccc tggcaccaac   3000

attgttctgg gagcactgcc tgaagacaga cacattgaca ggctggcaaa gaggcagaga   3060

cctggagaga gactggacct ggccatgctg gctgcaatca gaagggtgta tggactgctg   3120

gcaaacactg tgagatacct ccagtgtgga ggctcttgga gagaggactg gggacagctc   3180

tctggaacag cagtgccccc tcaaggagct gagccccagt ccaatgctgg tccaagaccc   3240

cacattgggg acaccctgtt caccctgttc agagcccctg agctgctggc tcccaatgga   3300

gacctgtaca atgtgtttgc ctgggctctg gatgttctag ccaagaggct gaggtccatg   3360

catgtgttca tcctggacta tgaccagtcc cctgctggat gcagagatgc tctgctgcaa   3420

ctaacctctg gcatggtgca gacccatgtg accacccctg gcagcatccc caccatctgt   3480

gacctagcca gaacctttgc cagggagatg ggagaggcca actaaacctg agctagctcg   3540

acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat   3600

gctttatttg tgaaatttgt gatgctattg ctttatttgt gaaatttgtg atgctattgc   3660

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt   3720

tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa   3780

atgtggtaga tccatttttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt   3840

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg   3900

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg   3960

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc   4020

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc   4080

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata   4140

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg   4200

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct   4260

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa   4320

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc   4380

tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt   4440

aggtcgttcg ctccaagctg ggctgtgtgc acgacccccc cgttcagccc gaccgctgcg   4500

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg   4560

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct   4620

tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc   4680

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg   4740

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc   4800

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt   4860

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa   4920

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat   4980

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct   5040

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg   5100

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag   5160

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta   5220

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg   5280

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg   5340

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct   5400

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta   5460

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg   5520

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc   5580

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg   5640

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga   5700

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg   5760

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat   5820

gttgaatact catactcttc ctttttcaat attattgaag catttatcag ggttattgtc   5880

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca   5940

catttccccg aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct   6000

ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa   6060

acctctgaca catgcagctc ccggagacgg tcacagcttg tctgtaagcg gatgccggga   6120

gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact   6180

atgcggcatc agagcagatt gtactgagag tgcaccatat gcggtgtgaa ataccgcaca   6240

gatgcgtaag gagaaaatac cgcatcaggc gccaatatta aacttgatga gctctagaga   6300

tggtcatgca ttttaaaaag aattactcaa aatattgtct tggaatacca gagagcaagt   6360

gctttaagta taggctggga agtaaaatgc taaaggaatg agaaggcatt tggggttgag   6420

ttcaacctaa gaggcagggg agccacaggg aaagacctag cacctgccac agaagagaat   6480

taggaagcag aattgaacta taagcaattt tgaggtgttc gttgggctgc agttgaaata   6540

ttttttgagg ttaatgagac atttgaaatg gccgtgtatt gtttaactct tgcatagtcc   6600

tgcataggga acaatctaat aggatttctc tgtgaatcaa gtcttagaaa tttgctttta   6660

atttttatga aaaacgccca tttctttgtt tttgagacag agtcctgctc tgtcatccag   6720

gctgggttgc agtggcgtga tcttggccca ctgcaatctc tgcctcctgg gttcaggcaa   6780

ttttcctgtc tcagcctccc gagtagctgg gatttcaagt gcctgccacc atgcccggct   6840

aaattttttt gtatttttgg tacagatgga gtatcaccat gttggccagg ctggtctcga   6900

actcctgacc tcaagtgatt caccagcctt gacctcccaa agtgttggga tcacaggcat   6960

gagccactgt gcctgtgccc caaaacacca atttctgatg tgtgatgcat gtaagataga   7020

acaaacttca gtaaagcggg gacttgaaaa gaggctttgg taacagctgt cagcattaac   7080

ccttgcccct ccgtacctcc taatcccacc cctgctcaaa gtatgttcat ctgagaattt   7140

gtctccataa ctatgtgact ataaaaattc tcatcgattt tgttagttga tcaattgagg   7200

gaaaaacata tgttacttga tataactggt gggtcaaaag aattaaccca ggcaaatttg   7260

agataggtgg atgggatgat ggattgaaaa tacagctgct ctctttccaa tcatgtacta   7320

agtaatttgg gaaagattga tctaattggg tctagagagt acacttcaca tggcattgtt   7380

tgactttttt tctgcatcgc tagcgatctg tgcattacaa ctcaaatcag tcgggtttcc   7440

tggcatatgt aattgccaat gttttttacc agaagagaaa cattactccc acctcttctt   7500

attatgttac aaactatagt gctaatgacc atcgaccaac agtgactttc aggatgacct   7560

gtgtgagttt tatctgaaac catgtgaatt tttcatctta aaagtccctt agaatctcag   7620

tctatgtaca ctcaggtttg ttgcaggttt agagttccgt gttttttgtt tctaatgtag   7680

acacagcctt ataatttaca acagcattca ctaattaaaa ttgtaagcat aattactatc   7740

cacgatactt attattagtt tgcattcata aagctcaaaa ttcacttcat cctttcaagt   7800

agtgaataat tagtttcttt gggtttgcag ctttatcatc cttttatgac ccatttggaa   7860

gaaataaaca accaaccccc tggaagactg ctttaaaaag ctggaaatac attgtccagc   7920

tagtacaatg aggctaatac aatgtggaaa atattacttt tctttgattt tagtagcctg   7980

tttatcttta catttactga acaaataact attgagcacc taatgtatac tgggaccctt   8040

ggggaggcaa agatgaatca aagattctgt ccttaaagac cttaagacgc gttgacattg   8100

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat   8160

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc   8220

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca   8280

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta   8340

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta   8400

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat   8460

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga   8520

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca   8580

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg   8640

taggcgtgta cggtgggagg tctatataag cagagctccc cgggagcttg tatatccatt   8700

ttcggatctg atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg   8760

cacgcaggtt ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag   8820

acaatcggct gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt   8880

tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta   8940

tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg   9000

ggaagggact ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt   9060

gctcctgccg agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat   9120

ccggctacct gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg   9180

atggaagccg gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca   9240

gccgaactgt tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc   9300

catggcgatg cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc   9360

gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat   9420

attgctgaag agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc   9480

gctcccgatt cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgattaatt   9540

aacaggactg accgtgctac gagatttcga ttccaccgcc gccttctatg aaaggttggg   9600

cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct   9660

ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa   9720

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc   9780

caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc   9840

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa   9900

catacaggat ccactagcga tgtacgggcc agatatacgc gttgacattg attattgact   9960

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc  10020

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg  10080

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa  10140

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca  10200

agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac  10260

atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc  10320

atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga  10380

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg  10440

gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta  10500

cggtgggagg tctatataag cagagctctc tggctaacta gagaacccac tgcttactgg  10560

cttatcgaaa ttaatacgac tcactatagg gagacccaag ctggctagcc tta         10613

<210>  59
<211>  12415
<212>  DNA
<213>  Artificial

<220>
<223>  pIM.RAG1.CMV.Neo.Luc

<400>  59
atggaagatg ccaaaaacat taagaagggc ccagcgccat tctacccact cgaagacggg     60

accgccggcg agcagctgca caaagccatg aagcgctacg ccctggtgcc cggcaccatc    120

gcctttaccg acgcacatat cgaggtggac attacctacg ccgagtactt cgagatgagc    180

gttcggctgg cagaagctat gaagcgctat gggctgaata caaaccatcg gatcgtggtg    240

tgcagcgaga atagcttgca gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg    300

gctgtggccc cagctaacga catctacaac gagcgcgagc tgctgaacag catgggcatc    360

agccagccca ccgtcgtatt cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa    420

aagaagctac cgatcataca aaagatcatc atcatggata gcaagaccga ctaccagggc    480

ttccaaagca tgtacacctt cgtgacttcc catttgccac ccggcttcaa cgagtacgac    540

ttcgtgcccg agagcttcga ccgggacaaa accatcgccc tgatcatgaa cagtagtggc    600

agtaccggat tgcccaaggg cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt    660

catgcccgcg accccatctt cggcaaccag atcatccccg acaccgctat cctcagcgtg    720

gtgccatttc accacggctt cggcatgttc accacgctgg gctacttgat ctgcggcttt    780

cgggtcgtgc tcatgtaccg cttcgaggag gagctattct tgcgcagctt gcaagactat    840

aagattcaat ctgccctgct ggtgcccaca ctatttagct tcttcgctaa gagcactctc    900

atcgacaagt acgacctaag caacttgcac gagatcgcca gcggcggggc gccgctcagc    960

aaggaggtag gtgaggccgt ggccaaacgc ttccacctac caggcatccg ccagggctac   1020

ggcctgacag aaacaaccag cgccattctg atcacccccg aaggggacga caagcctggc   1080

gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg tggacttgga caccggtaag   1140

acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg gccccatgat catgagcggc   1200

tacgttaaca accccgaggc tacaaacgct ctcatcgaca aggacggctg gctgcacagc   1260

ggcgacatcg cctactggga cgaggacgag cacttcttca tcgtggaccg gctgaagagc   1320

ctgatcaaat acaagggcta ccaggtagcc ccagccgaac tggagagcat cctgctgcaa   1380

caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg   1440

cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga ccgagaagga gatcgtggac   1500

tatgtggcca gccaggttac aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac   1560

gaggtgccta aaggactgac cggcaagttg gacgcccgca agatccgcga gattctcatt   1620

aaggccaaga agggcggcaa gatcgccgtg taataattct agagtcgggg cggccggccg   1680

cttcgagcag acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag   1740

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattaaa   1800

acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc   1860

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag   1920

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag   1980

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct   2040

atggcttctg aggcggaaag aacggatccg cagcctcttt cccacccacc ttgggactca   2100

gttctgcccc agatgaaatt cagcacccac atattaaatt ttcagaatgg aaatttaagc   2160

tgttccgggt gagatccttt gaaaagacac ctgaagaagc tcaaaaggaa aagaaggatt   2220

cctttgaggg gaaaccctct ctggagcaat ctccagcagt cctggacaag gctgatggtc   2280

agaagccagt cccaactcag ccattgttaa aagcccaccc taagttttcg aagaaatttc   2340

acgacaacga gaaagcaaga ggcaaagcga tccatcaagc caaccttcga catctctgcc   2400

gcatctgtgg gaattctttt agagctgatg agcacaacag gagatatcca gtccatggtc   2460

ctgtggatgg taaaacccta ggccttttac gaaagaagga aaagagagct acttcctggc   2520

cggacctcat tgccaaggtt ttccggatcg atgtgaaggc agatgttgac tcgatccacc   2580

ccactgagtt ctgccataac tgctggagca tcatgcacag gaagtttagc agtgccccat   2640

gtgaggttta cttcccgagg aacgtgacca tggagtggca cccccacaca ccatcctgtg   2700

acatctgcaa cactgcccgt cggggactca agaggaagag tcttcagcca aacttgcagc   2760

tcagcaaaaa actcaaaact gtgcttgacc aagcaagaca agcccgtcag cacaagagaa   2820

gagctcaggc aaggatcagc agcaaggatg tcatgaagaa gatcgccaac tgcagtaaga   2880

tacatcttag taccaagctc cttgcagtgg acttcccaga gcactttgtg aaatccatct   2940

cctgccagat ctgtgaacac attctggctg accctgtgga gaccaactgt aagcatgtct   3000

tttgccgggt ctgcattctc agatgcctca aagtcatggg cagctattgt ccctcttgcc   3060

gatatccatg cttccctact gacctggaga gtccagtgaa gtcctttctg agcgtcttga   3120

attccctgat ggtgaaatgt ccagcaaaag agtgcaatga ggaggtcagt ttggaaaaat   3180

ataatcacca catctcaagt cacaaggaat caaaagagat ttttgtgcac attaataaag   3240

ggggtcgagt aacgcgtgca ggcatgcaag ctggccgcaa taaaatatct ttattttcat   3300

tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac atacgctctc catcaaaaca   3360

aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag tgcaagtgca ggtgccagaa   3420

catttctcta tcgaaggatc tgcgatcgct ccggtgcccg tcagtgggca gagcgcacat   3480

cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa   3540

ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg   3600

gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt   3660

ttgccgccag aacacagctg aagcttcgag gggctcgcat ctctccttca cgcgcccgcc   3720

gccctacctg aggccgccat ccacgccggt tgagtcgcgt tctgccgcct cccgcctgtg   3780

gtgcctcctg aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg agaccgggcc   3840

tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg ctttgcctga   3900

ccctgcttgc tcaactctac gtctttgttt cgttttctgt tctgcgccgt tacagatcca   3960

agctgtgacc ggcgcctacg taagtgatat ctactagatt tatcaaaaag agtgttgact   4020

tgtgagcgct cacaattgat acttagattc atcgagaggg acacgtcgac tactaacctt   4080

cttctctttc ctacagctga gatcaccggc gaaggagggc caccatggct tcttaccctg   4140

gacaccagca tgcttctgcc tttgaccagg ctgccagatc caggggccac tccaacagga   4200

gaactgccct aagacccaga agacagcagg aagccactga ggtgaggcct gagcagaaga   4260

tgccaaccct gctgagggtg tacattgatg gacctcatgg catgggcaag accaccacca   4320

ctcaactgct ggtggcactg ggctccaggg atgacattgt gtatgtgcct gagccaatga   4380

cctactggag agtgctagga gcctctgaga ccattgccaa catctacacc acccagcaca   4440

ggctggacca gggagaaatc tctgctggag atgctgctgt ggtgatgacc tctgcccaga   4500

tcacaatggg aatgccctat gctgtgactg atgctgttct ggctcctcac attggaggag   4560

aggctggctc ttctcatgcc cctccacctg ccctgaccct gatctttgac agacacccca   4620

ttgcagccct gctgtgctac ccagcagcaa ggtacctcat gggctccatg accccacagg   4680

ctgtgctggc ttttgtggcc ctgatccctc caaccctccc tggcaccaac attgttctgg   4740

gagcactgcc tgaagacaga cacattgaca ggctggcaaa gaggcagaga cctggagaga   4800

gactggacct ggccatgctg gctgcaatca gaagggtgta tggactgctg gcaaacactg   4860

tgagatacct ccagtgtgga ggctcttgga gagaggactg gggacagctc tctggaacag   4920

cagtgccccc tcaaggagct gagccccagt ccaatgctgg tccaagaccc cacattgggg   4980

acaccctgtt caccctgttc agagcccctg agctgctggc tcccaatgga gacctgtaca   5040

atgtgtttgc ctgggctctg gatgttctag ccaagaggct gaggtccatg catgtgttca   5100

tcctggacta tgaccagtcc cctgctggat gcagagatgc tctgctgcaa ctaacctctg   5160

gcatggtgca gacccatgtg accacccctg gcagcatccc caccatctgt gacctagcca   5220

gaacctttgc cagggagatg ggagaggcca actaaacctg agctagctcg acatgataag   5280

atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg   5340

tgaaatttgt gatgctattg ctttatttgt gaaatttgtg atgctattgc tttatttgta   5400

accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag   5460

gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtaga   5520

tccatttttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac   5580

aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt   5640

gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc   5700

gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg   5760

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt   5820

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa   5880

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc   5940

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag   6000

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt   6060

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg   6120

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg   6180

ctccaagctg ggctgtgtgc acgacccccc cgttcagccc gaccgctgcg ccttatccgg   6240

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac   6300

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg   6360

gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt   6420

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg   6480

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc   6540

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt   6600

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt   6660

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag   6720

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt   6780

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc   6840

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc   6900

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg   6960

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac   7020

aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg   7080

atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc   7140

tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact   7200

gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc   7260

aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat   7320

acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc   7380

ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac   7440

tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa   7500

aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact   7560

catactcttc ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg   7620

atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg   7680

aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag   7740

gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa acctctgaca   7800

catgcagctc ccggagacgg tcacagcttg tctgtaagcg gatgccggga gcagacaagc   7860

ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact atgcggcatc   7920

agagcagatt gtactgagag tgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag   7980

gagaaaatac cgcatcaggc gccaatatta aacttgatga gctctagaga tggtcatgca   8040

ttttaaaaag aattactcaa aatattgtct tggaatacca gagagcaagt gctttaagta   8100

taggctggga agtaaaatgc taaaggaatg agaaggcatt tggggttgag ttcaacctaa   8160

gaggcagggg agccacaggg aaagacctag cacctgccac agaagagaat taggaagcag   8220

aattgaacta taagcaattt tgaggtgttc gttgggctgc agttgaaata ttttttgagg   8280

ttaatgagac atttgaaatg gccgtgtatt gtttaactct tgcatagtcc tgcataggga   8340

acaatctaat aggatttctc tgtgaatcaa gtcttagaaa tttgctttta atttttatga   8400

aaaacgccca tttctttgtt tttgagacag agtcctgctc tgtcatccag gctgggttgc   8460

agtggcgtga tcttggccca ctgcaatctc tgcctcctgg gttcaggcaa ttttcctgtc   8520

tcagcctccc gagtagctgg gatttcaagt gcctgccacc atgcccggct aaattttttt   8580

gtatttttgg tacagatgga gtatcaccat gttggccagg ctggtctcga actcctgacc   8640

tcaagtgatt caccagcctt gacctcccaa agtgttggga tcacaggcat gagccactgt   8700

gcctgtgccc caaaacacca atttctgatg tgtgatgcat gtaagataga acaaacttca   8760

gtaaagcggg gacttgaaaa gaggctttgg taacagctgt cagcattaac ccttgcccct   8820

ccgtacctcc taatcccacc cctgctcaaa gtatgttcat ctgagaattt gtctccataa   8880

ctatgtgact ataaaaattc tcatcgattt tgttagttga tcaattgagg gaaaaacata   8940

tgttacttga tataactggt gggtcaaaag aattaaccca ggcaaatttg agataggtgg   9000

atgggatgat ggattgaaaa tacagctgct ctctttccaa tcatgtacta agtaatttgg   9060

gaaagattga tctaattggg tctagagagt acacttcaca tggcattgtt tgactttttt   9120

tctgcatcgc tagcgatctg tgcattacaa ctcaaatcag tcgggtttcc tggcatatgt   9180

aattgccaat gttttttacc agaagagaaa cattactccc acctcttctt attatgttac   9240

aaactatagt gctaatgacc atcgaccaac agtgactttc aggatgacct gtgtgagttt   9300

tatctgaaac catgtgaatt tttcatctta aaagtccctt agaatctcag tctatgtaca   9360

ctcaggtttg ttgcaggttt agagttccgt gttttttgtt tctaatgtag acacagcctt   9420

ataatttaca acagcattca ctaattaaaa ttgtaagcat aattactatc cacgatactt   9480

attattagtt tgcattcata aagctcaaaa ttcacttcat cctttcaagt agtgaataat   9540

tagtttcttt gggtttgcag ctttatcatc cttttatgac ccatttggaa gaaataaaca   9600

accaaccccc tggaagactg ctttaaaaag ctggaaatac attgtccagc tagtacaatg   9660

aggctaatac aatgtggaaa atattacttt tctttgattt tagtagcctg tttatcttta   9720

catttactga acaaataact attgagcacc taatgtatac tgggaccctt ggggaggcaa   9780

agatgaatca aagattctgt ccttaaagac cttaagacgc gttgacattg attattgact   9840

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc   9900

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg   9960

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa  10020

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca  10080

agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac  10140

atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc  10200

atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga  10260

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg  10320

gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta  10380

cggtgggagg tctatataag cagagctccc cgggagcttg tatatccatt ttcggatctg  10440

atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt  10500

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct  10560

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga  10620

ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta tcgtggctgg  10680

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact  10740

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg  10800

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct  10860

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg  10920

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt  10980

tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg  11040

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc  11100

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag  11160

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt  11220

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgattaatt aacaggactg  11280

accgtgctac gagatttcga ttccaccgcc gccttctatg aaaggttggg cttcggaatc  11340

gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct ggagttcttc  11400

gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca  11460

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc  11520

aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc gtaatcatgg  11580

tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacaggat  11640

ccactagcga tgtacgggcc agatatacgc gttgacattg attattgact agttattaat  11700

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac  11760

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa  11820

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt  11880

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc  11940

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat  12000

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc  12060

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc  12120

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa  12180

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg  12240

tctatataag cagagctctc tggctaacta gagaacccac tgcttactgg cttatcgaaa  12300

ttaatacgac tcactatagg gagacccaag ctggctagcc ttaggcgcgc cagatctgta  12360

cattcgaaga tatcttaatt aagcggccgc gaattcacta gtgattgcag aattc       12415

<210>  60
<211>  6089
<212>  DNA
<213>  Artificial

<220>
<223>  hsRAG1 meganuclease expression plasmid

<400>  60
atggccaata ccaaatataa cgaagagttc ctgctgtacc tggccggctt tgtggacggt     60

gacggtagca tcatcgctca gattaatcca aaccagtctt ctaagtttaa acatcgtcta    120

cgtttgacct tttatgtgac tcaaaagacc cagcgccgtt ggtttctgga caaactagtg    180

gatgaaattg gcgttggtta cgtacgtgat tctggatccg tttcccagta cgttttaagc    240

gaaatcaagc cgctgcacaa cttcctgact caactgcagc cgtttctgga actgaaacag    300

aaacaggcaa acctggttct gaaaattatc gaacagctgc cgtctgcaaa agaatccccg    360

gacaaattcc tggaagtttg tacctgggtg gatcagattg cagctctgaa cgattctaag    420

acgcgtaaaa ccacttctga aaccgttcgt gctgtgctgg acagcctgag cgggaagaag    480

aaatcctccc cggcggccgg tggatctgat aagtataatc aggctctgtc taaatacaac    540

caagcactgt ccaagtacaa tcaggccctg tctggtggag gcggttccaa caaaaagttc    600

ctgctgtatc ttgctggatt tgtggattct gatggctcca tcattgctca gataaaacca    660

cgtcaatcta acaagttcaa acaccagctc tccttgactt ttgcagtcac tcagaagaca    720

caaagaaggt ggttcttgga caaattggtt gataggattg gtgtgggcta tgtctatgac    780

agtggctctg tgtcagacta ccgcctgtct gaaattaagc ctcttcataa ctttctcacc    840

caactgcaac ccttcttgaa gctcaaacag aagcaagcaa atctggtttt gaaaatcatc    900

gagcaactgc catctgccaa ggagtcccct gacaagtttc ttgaagtgtg tacttgggtg    960

gatcagattg ctgccttgaa tgactccaag accagaaaaa ccacctctga gactgtgagg   1020

gcagttctgg atagcctctc tgagaagaaa aagtcctctc cttagtctag agggcccgcg   1080

gttcgaaggt aagcctatcc ctaaccctct cctcggtctc gattctacgc gtaccggtta   1140

gtaatgagtt taaacggggg aggctaactg aaacacggaa ggagacaata ccggaaggaa   1200

cccgcgctat gacggcaata aaaagacaga ataaaacgca cgggtgttgg gtcgtttgtt   1260

cataaacgcg gggttcggtc ccagggctgg cactctgtcg ataccccacc gagaccccat   1320

tggggccaat acgcccgcgt ttcttccttt tccccacccc accccccaag ttcgggtgaa   1380

ggcccagggc tcgcagccaa cgtcggggcg gcaggccctg ccatagcaga tctgcgcagc   1440

tggggctcta gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg   1500

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct   1560

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggc   1620

atccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag   1680

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg   1740

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc   1800

tcggtctatt cttttgattt ataagggatt ttggggattt cggcctattg gttaaaaaat   1860

gagctgattt aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt   1920

gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt   1980

cagcaaccag gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc   2040

atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc   2100

cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg   2160

ccgaggccgc ctctgcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc   2220

taggcttttg caaaaagctc ccgggagctt gtatatccat tttcggatct gatcagcacg   2280

tgttgacaat taatcatcgg catagtatat cggcatagta taatacgaca aggtgaggaa   2340

ctaaaccatg gccaagcctt tgtctcaaga agaatccacc ctcattgaaa gagcaacggc   2400

tacaatcaac agcatcccca tctctgaaga ctacagcgtc gccagcgcag ctctctctag   2460

cgacggccgc atcttcactg gtgtcaatgt atatcatttt actgggggac cttgtgcaga   2520

actcgtggtg ctgggcactg ctgctgctgc ggcagctggc aacctgactt gtatcgtcgc   2580

gatcggaaat gagaacaggg gcatcttgag cccctgcgga cggtgccgac aggtgcttct   2640

cgatctgcat cctgggatca aagccatagt gaaggacagt gatggacagc cgacggcagt   2700

tgggattcgt gaattgctgc cctctggtta tgtgtgggag ggctaagcac ttcgtggccg   2760

aggagcagga ctgacacgtg ctacgagatt tcgattccac cgccgccttc tatgaaaggt   2820

tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc ggggatctca   2880

tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt tacaaataaa   2940

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt   3000

tgtccaaact catcaatgta tcttatcatg tctgtatacc gtcgacctct agctagagct   3060

tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac   3120

acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac   3180

tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc   3240

tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg   3300

cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc   3360

actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt   3420

gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc   3480

ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa   3540

acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc   3600

ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg   3660

cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc   3720

tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc   3780

gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca   3840

ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact   3900

acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg   3960

gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc ggtttttttg   4020

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt   4080

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat   4140

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct   4200

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta   4260

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa   4320

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac   4380

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa   4440

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag   4500

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg   4560

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag   4620

ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg   4680

tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc   4740

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat   4800

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata   4860

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa   4920

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca   4980

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc   5040

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc   5100

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg   5160

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac   5220

ctgacgtcga cggatcggga gatctcccga tcccctatgg tgcactctca gtacaatctg   5280

ctctgatgcc gcatagttaa gccagtatct gctccctgct tgtgtgttgg aggtcgctga   5340

gtagtgcgcg agcaaaattt aagctacaac aaggcaaggc ttgaccgaca attgcatgaa   5400

gaatctgctt agggttaggc gttttgcgct gcttcgcgat gtacgggcca gatatacgcg   5460

ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag   5520

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc   5580

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg   5640

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca   5700

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc   5760

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt   5820

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata   5880

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt   5940

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca   6000

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctctct ggctaactag   6060

agaacccact gcttactggc ttatcgacc                                     6089





