                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Activatable constructs

<130>  8113.204-WO

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Asn Cys Gln Ile Ala Ile Leu Tyr Gln Arg Phe Gln Arg Val 
1               5                   10                  15      


Val Phe Gly Ile Ser Gln Leu Leu Cys Phe Ser Ala Leu Ile Ser Glu 
            20                  25                  30          


Leu Thr Asn Gln Lys Glu Val Ala Trp Thr Tyr His Tyr Ser Thr Lys 
        35                  40                  45              


Ala Tyr Ser Trp Asn Ile Ser Arg Lys Tyr Cys Gln Asn Arg Tyr Thr 
    50                  55                  60                  


Asp Leu Val Ala Ile Gln Asn Lys Asn Glu Ile Asp Tyr Leu Asn Lys 
65                  70                  75                  80  


Val Leu Pro Tyr Tyr Ser Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Asn 
                85                  90                  95      


Asn Lys Thr Trp Thr Trp Val Gly Thr Lys Lys Ala Leu Thr Asn Glu 
            100                 105                 110         


Ala Glu Asn Trp Ala Asp Asn Glu Pro Asn Asn Lys Arg Asn Asn Glu 
        115                 120                 125             


Asp Cys Val Glu Ile Tyr Ile Lys Ser Pro Ser Ala Pro Gly Lys Trp 
    130                 135                 140                 


Asn Asp Glu His Cys Leu Lys Lys Lys His Ala Leu Cys Tyr Thr Ala 
145                 150                 155                 160 


Ser Cys Gln Asp Met Ser Cys Ser Lys Gln Gly Glu Cys Leu Glu Thr 
                165                 170                 175     


Ile Gly Asn Tyr Thr Cys Ser Cys Tyr Pro Gly Phe Tyr Gly Pro Glu 
            180                 185                 190         


Cys Glu Tyr Val Arg Glu Cys Gly Glu Leu Glu Leu Pro Gln His Val 
        195                 200                 205             


Leu Met Asn Cys Ser His Pro Leu Gly Asn Phe Ser Phe Asn Ser Gln 
    210                 215                 220                 


Cys Ser Phe His Cys Thr Asp Gly Tyr Gln Val Asn Gly Pro Ser Lys 
225                 230                 235                 240 


Leu Glu Cys Leu Ala Ser Gly Ile Trp Thr Asn Lys Pro Pro Gln Cys 
                245                 250                 255     


Leu Ala Ala Gln Cys Pro Pro Leu Lys Ile Pro Glu Arg Gly Asn Met 
            260                 265                 270         


Thr Cys Leu His Ser Ala Lys Ala Phe Gln His Gln Ser Ser Cys Ser 
        275                 280                 285             


Phe Ser Cys Glu Glu Gly Phe Ala Leu Val Gly Pro Glu Val Val Gln 
    290                 295                 300                 


Cys Thr Ala Ser Gly Val Trp Thr Ala Pro Ala Pro Val Cys Lys Ala 
305                 310                 315                 320 


Val Gln Cys Gln His Leu Glu Ala Pro Ser Glu Gly Thr Met Asp Cys 
                325                 330                 335     


Val His Pro Leu Thr Ala Phe Ala Tyr Gly Ser Ser Cys Lys Phe Glu 
            340                 345                 350         


Cys Gln Pro Gly Tyr Arg Val Arg Gly Leu Asp Met Leu Arg Cys Ile 
        355                 360                 365             


Asp Ser Gly His Trp Ser Ala Pro Leu Pro Thr Cys Glu Ala Ile Ser 
    370                 375                 380                 


Cys Glu Pro Leu Glu Ser Pro Val His Gly Ser Met Asp Cys Ser Pro 
385                 390                 395                 400 


Ser Leu Arg Ala Phe Gln Tyr Asp Thr Asn Cys Ser Phe Arg Cys Ala 
                405                 410                 415     


Glu Gly Phe Met Leu Arg Gly Ala Asp Ile Val Arg Cys Asp Asn Leu 
            420                 425                 430         


Gly Gln Trp Thr Ala Pro Ala Pro Val Cys Gln Ala Leu Gln Cys Gln 
        435                 440                 445             


Asp Leu Pro Val Pro Asn Glu Ala Arg Val Asn Cys Ser His Pro Phe 
    450                 455                 460                 


Gly Ala Phe Arg Tyr Gln Ser Val Cys Ser Phe Thr Cys Asn Glu Gly 
465                 470                 475                 480 


Leu Leu Leu Val Gly Ala Ser Val Leu Gln Cys Leu Ala Thr Gly Asn 
                485                 490                 495     


Trp Asn Ser Val Pro Pro Glu Cys Gln Ala Ile Pro Cys Thr Pro Leu 
            500                 505                 510         


Leu Ser Pro Gln Asn Gly Thr Met Thr Cys Val Gln Pro Leu Gly Ser 
        515                 520                 525             


Ser Ser Tyr Lys Ser Thr Cys Gln Phe Ile Cys Asp Glu Gly Tyr Ser 
    530                 535                 540                 


Leu Ser Gly Pro Glu Arg Leu Asp Cys Thr Arg Ser Gly Arg Trp Thr 
545                 550                 555                 560 


Asp Ser Pro Pro Met Cys Glu Ala Ile Lys Cys Pro Glu Leu Phe Ala 
                565                 570                 575     


Pro Glu Gln Gly Ser Leu Asp Cys Ser Asp Thr Arg Gly Glu Phe Asn 
            580                 585                 590         


Val Gly Ser Thr Cys His Phe Ser Cys Asp Asn Gly Phe Lys Leu Glu 
        595                 600                 605             


Gly Pro Asn Asn Val Glu Cys Thr Thr Ser Gly Arg Trp Ser Ala Thr 
    610                 615                 620                 


Pro Pro Thr Cys Lys Gly Ile Ala Ser Leu Pro Thr Pro Gly Leu Gln 
625                 630                 635                 640 


Cys Pro Ala Leu Thr Thr Pro Gly Gln Gly Thr Met Tyr Cys Arg His 
                645                 650                 655     


His Pro Gly Thr Phe Gly Phe Asn Thr Thr Cys Tyr Phe Gly Cys Asn 
            660                 665                 670         


Ala Gly Phe Thr Leu Ile Gly Asp Ser Thr Leu Ser Cys Arg Pro Ser 
        675                 680                 685             


Gly Gln Trp Thr Ala Val Thr Pro Ala Cys Arg Ala Val Lys Cys Ser 
    690                 695                 700                 


Glu Leu His Val Asn Lys Pro Ile Ala Met Asn Cys Ser Asn Leu Trp 
705                 710                 715                 720 


Gly Asn Phe Ser Tyr Gly Ser Ile Cys Ser Phe His Cys Leu Glu Gly 
                725                 730                 735     


Gln Leu Leu Asn Gly Ser Ala Gln Thr Ala Cys Gln Glu Asn Gly His 
            740                 745                 750         


Trp Ser Thr Thr Val Pro Thr Cys Gln Ala Gly Pro Leu Thr Ile Gln 
        755                 760                 765             


Glu Ala Leu Thr Tyr Phe Gly Gly Ala Val Ala Ser Thr Ile Gly Leu 
    770                 775                 780                 


Ile Met Gly Gly Thr Leu Leu Ala Leu Leu Arg Lys Arg Phe Arg Gln 
785                 790                 795                 800 


Lys Asp Asp Gly Lys Cys Pro Leu Asn Pro His Ser His Leu Gly Thr 
                805                 810                 815     


Tyr Gly Val Phe Thr Asn Ala Ala Phe Asp Pro Ser Pro 
            820                 825                 


<210>  2
<211>  537
<212>  DNA
<213>  Artificial

<220>
<223>  EP-FpA-PB1.3 HC-V

<400>  2
aagcttgccg ccaccatggg atggtctggt gtatttcttt ttctcctgag tggtacagct       60

ggcgtccact caagcgtcct gcagtgtctg gctacaggga attggaactc agtgcctcct      120

gaatgtcaag ccgacttcct tgctgaaggg ggtggtgtgc gcatcgtggg agaggctcaa      180

ctgcaacagt ctgggcccga actggtagag cctggggcaa gtgtgaaggt atcctgcaaa      240

gcgtcagggt atacatttac taactacgtg atgcactggg tgaaacagaa gccaggacaa      300

ggtttggaat ggatcgggtt cattaatcct tccaatgatg ggcctaagta taacgaacga      360

ttcaagaaca aggctacact gacgtccgat aaatcctcct ctacagcata catggaactg      420

agctccttga cttcagaggt aagcgccgtg tacttctgcg caagagccag gcccggattc      480

gactggtatt tcgacgtgtg gggcgctggc actaccgtca cagtcagttc tgctagc         537


<210>  3
<211>  172
<212>  PRT
<213>  Artificial

<220>
<223>  EP-FpA-PB1.3 HC-V

<400>  3

Met Gly Trp Ser Gly Val Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Val Leu Gln Cys Leu Ala Thr Gly Asn Trp Asn Ser 
            20                  25                  30          


Val Pro Pro Glu Cys Gln Ala Asp Phe Leu Ala Glu Gly Gly Gly Val 
        35                  40                  45              


Arg Ile Val Gly Glu Ala Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
    50                  55                  60                  


Glu Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
65                  70                  75                  80  


Phe Thr Asn Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly 
                85                  90                  95      


Leu Glu Trp Ile Gly Phe Ile Asn Pro Ser Asn Asp Gly Pro Lys Tyr 
            100                 105                 110         


Asn Glu Arg Phe Lys Asn Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser 
        115                 120                 125             


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Val Ser Ala 
    130                 135                 140                 


Val Tyr Phe Cys Ala Arg Ala Arg Pro Gly Phe Asp Trp Tyr Phe Asp 
145                 150                 155                 160 


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                165                 170         


<210>  4
<211>  438
<212>  DNA
<213>  Artificial

<220>
<223>  PB1.3 HC-V

<400>  4
aagcttgccg ccaccatggg atggtcagga gtttttcttt ttctgctctc tggtactgct       60

ggcgtgcata gtgaggctca gcttcagcag tccgggccag aactcgttga acccggggct      120

tcagtcaagg ttagttgcaa ggcttcaggt tatacattca caaactacgt aatgcactgg      180

gtcaagcaga agccagggca agggcttgag tggatcgggt tcattaatcc gtccaatgat      240

ggacctaagt acaacgaaag gtttaagaac aaggcaactt tgacgagcga caagagttcc      300

tccactgcat atatggagct cagctctctg accagcgaag ttagtgcggt ctacttctgc      360

gctagagcta ggcctgggtt cgattggtac tttgatgtgt ggggagctgg aacaacagtt      420

accgtttctt ctgctagc                                                    438


<210>  5
<211>  139
<212>  PRT
<213>  Artificial

<220>
<223>  PB1.3 HC-V

<400>  5

Met Gly Trp Ser Gly Val Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Ala Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Glu 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Phe Ile Asn Pro Ser Asn Asp Gly Pro Lys Tyr Asn 
65                  70                  75                  80  


Glu Arg Phe Lys Asn Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Val Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ala Arg Pro Gly Phe Asp Trp Tyr Phe Asp Val 
        115                 120                 125             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 


<210>  6
<211>  414
<212>  DNA
<213>  Artificial

<220>
<223>  PB1.3 LC-V

<400>  6
aagcttgccg ccaccatggg cataaagatg gaatcacaga tacaggtgtt cgtgtatatg       60

ctgctctggc tgtctggcgt ggacggcgac atagtgatga cgcagtcaca gaaattcatg      120

tccacaagcg tcggggatag ggtgagcgtt acgtgtaaag catcccagaa cgtagccaca      180

aacgtcgtgt ggtatcagca gaggcccgga cagtcaccca aggccctcat ctataccgcg      240

tcctataggt ttagcggtgt gccggagcgc ttttcagggt ccggaagtgg aacagatttt      300

actctgacaa tcaccaacgt gcaaagtgag gacctcgccg actacttttg ccagcaatac      360

aataactatc cctatacttt tggcggaggc acaaaagtcg aaattcaacg tacg            414


<210>  7
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  PB1.3 LC-V

<400>  7

Met Gly Ile Lys Met Glu Ser Gln Ile Gln Val Phe Val Tyr Met Leu 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser Gln 
            20                  25                  30          


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys 
        35                  40                  45              


Ala Ser Gln Asn Val Ala Thr Asn Val Val Trp Tyr Gln Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Thr Ala Ser Tyr Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
            100                 105                 110         


Gln Gln Tyr Asn Asn Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Gln Arg 
    130         


<210>  8
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of anti-CD62P mAB

<400>  8

Glu Ala Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Ser Asn Asp Gly Pro Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Val Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Arg Pro Gly Phe Asp Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  9
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of anti-CD62P mAB

<400>  9

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Ala Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Tyr Arg Phe Ser Gly Val Pro Glu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Gln Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  10
<211>  885
<212>  DNA
<213>  Homo sapiens

<400>  10
atggagaccc ctgcctggcc ccgggtcccg cgccccgaga ccgccgtcgc tcggacgctc       60

ctgctcggct gggtcttcgc ccaggtggcc ggcgcttcag gcactacaaa tactgtggca      120

gcatataatt taacttggaa atcaactaat ttcaagacaa ttttggagtg ggaacccaaa      180

cccgtcaatc aagtctacac tgttcaaata agcactaagt caggagattg gaaaagcaaa      240

tgcttttaca caacagacac agagtgtgac ctcaccgacg agattgtgaa ggatgtgaag      300

cagacgtact tggcacgggt cttctcctac ccggcaggga atgtggagag caccggttct      360

gctggggagc ctctgtatga gaactcccca gagttcacac cttacctgga gacaaacctc      420

ggacagccaa caattcagag ttttgaacag gtgggaacaa aagtgaatgt gaccgtagaa      480

gatgaacgga ctttagtcag aaggaacaac actttcctaa gcctccggga tgtttttggc      540

aaggacttaa tttatacact ttattattgg aaatcttcaa gttcaggaaa gaaaacagcc      600

aaaacaaaca ctaatgagtt tttgattgat gtggataaag gagaaaacta ctgtttcagt      660

gttcaagcag tgattccctc ccgaacagtt aaccggaaga gtacagacag cccggtagag      720

tgtatgggcc aggagaaagg ggaattcaga gaaatattct acatcattgg agctgtggta      780

tttgtggtca tcatccttgt catcatcctg gctatatctc tacacaagtg tagaaaggca      840

ggagtggggc agagctggaa ggagaactcc ccactgaatg tttca                      885


<210>  11
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
1               5                   10                  15      


Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
            20                  25                  30          


Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
        35                  40                  45              


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
    50                  55                  60                  


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
65                  70                  75                  80  


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                85                  90                  95      


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
            100                 105                 110         


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
        115                 120                 125             


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
    130                 135                 140                 


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
145                 150                 155                 160 


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                165                 170                 175     


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
            180                 185                 190         


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
        195                 200                 205             


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
    210                 215                 220                 


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
225                 230                 235                 240 


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
                245                 250                 255     


Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
            260                 265                 270         


Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
        275                 280                 285             


Asn Ser Pro Leu Asn Val Ser 
    290                 295 


<210>  12
<211>  657
<212>  DNA
<213>  Homo sapiens

<400>  12
tcaggcacta caaatactgt ggcagcatat aatttaactt ggaaatcaac taatttcaag       60

acaattttgg agtgggaacc caaacccgtc aatcaagtct acactgttca aataagcact      120

aagtcaggag attggaaaag caaatgcttt tacacaacag acacagagtg tgacctcacc      180

gacgagattg tgaaggatgt gaagcagacg tacttggcac gggtcttctc ctacccggca      240

gggaatgtgg agagcaccgg ttctgctggg gagcctctgt atgagaactc cccagagttc      300

acaccttacc tggagacaaa cctcggacag ccaacaattc agagttttga acaggtggga      360

acaaaagtga atgtgaccgt agaagatgaa cggactttag tcagaaggaa caacactttc      420

ctaagcctcc gggatgtttt tggcaaggac ttaatttata cactttatta ttggaaatct      480

tcaagttcag gaaagaaaac agccaaaaca aacactaatg agtttttgat tgatgtggat      540

aaaggagaaa actactgttt cagtgttcaa gcagtgattc cctcccgaac agttaaccgg      600

aagagtacag acagcccggt agagtgtatg ggccaggaga aaggggaatt cagagaa         657


<210>  13
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


