                         SEQUENCE LISTING

<110>  Universit de Lige
 
<120>  A pharmaceutical composition for treatment of thrombosis-related 
       diseases comprising a fragment of prolactin (PRL)-growth hormone 
       (GH) - placental lactogen (PL)-family protein

<130>  P15209WO

<150>  EP 10 153 766.0
<151>  2010-02-17

<160>  36    

<170>  PatentIn version 3.3

<210>  1
<211>  200
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  1

Met Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu 
1               5                   10                  15      


Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn 
            20                  25                  30          


Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly 
        35                  40                  45              


Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu 
    50                  55                  60                  


Ala Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp 
65                  70                  75                  80  


Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu 
                85                  90                  95      


Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala 
            100                 105                 110         


Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu 
        115                 120                 125             


Glu Gly Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu 
    130                 135                 140                 


Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala 
145                 150                 155                 160 


Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu 
                165                 170                 175     


Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys 
            180                 185                 190         


Arg Ile Ile His Asn Asn Asn Cys 
        195                 200 


<210>  2
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  2

Met Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu 
1               5                   10                  15      


Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn 
            20                  25                  30          


Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly 
        35                  40                  45              


Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Ser His Thr Ser Ser Leu 
    50                  55                  60                  


Ala Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp 
65                  70                  75                  80  


Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu 
                85                  90                  95      


Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala 
            100                 105                 110         


Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr 
        115                 120                 


<210>  3
<211>  140
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  3

Met Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu 
1               5                   10                  15      


Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn 
            20                  25                  30          


Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly 
        35                  40                  45              


Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Ser His Thr Ser Ser Leu 
    50                  55                  60                  


Ala Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp 
65                  70                  75                  80  


Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu 
                85                  90                  95      


Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala 
            100                 105                 110         


Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu 
        115                 120                 125             


Glu Gly Met Glu Leu Ile Val Ser Gln Val His Pro 
    130                 135                 140 


<210>  4
<211>  143
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  4

Met Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu 
1               5                   10                  15      


Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn 
            20                  25                  30          


Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly 
        35                  40                  45              


Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Ser His Thr Ser Ser Leu 
    50                  55                  60                  


Ala Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp 
65                  70                  75                  80  


Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu 
                85                  90                  95      


Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala 
            100                 105                 110         


Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu 
        115                 120                 125             


Glu Gly Met Glu Leu Ile Val Ser Gln Val His Pro Arg Pro Pro 
    130                 135                 140             


<210>  5
<211>  192
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  5

Met Val Gln Thr Val Pro Leu Ser Arg Leu Phe Asp His Ala Met Leu 
1               5                   10                  15      


Gln Ala His Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu Phe 
            20                  25                  30          


Glu Glu Thr Tyr Ile Pro Lys Asp Gln Lys Tyr Ser Phe Leu His Asp 
        35                  40                  45              


Ser Gln Thr Ser Phe Cys Phe Ser Asp Ser Ile Pro Thr Pro Ser Asn 
    50                  55                  60                  


Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
65                  70                  75                  80  


Leu Leu Leu Ile Glu Ser Trp Leu Glu Pro Val Arg Phe Leu Arg Ser 
                85                  90                  95      


Met Phe Ala Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
            100                 105                 110         


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg 
        115                 120                 125             


Leu Glu Asp Gly Ser Arg Arg Thr Gly Gln Ile Leu Lys Gln Thr Tyr 
    130                 135                 140                 


Ser Lys Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn 
145                 150                 155                 160 


Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
                165                 170                 175     


Phe Leu Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190         


<210>  6
<211>  135
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  6

Met Val Gln Thr Val Pro Leu Ser Arg Leu Phe Asp His Ala Met Leu 
1               5                   10                  15      


Gln Ala His Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu Phe 
            20                  25                  30          


Glu Glu Thr Tyr Ile Pro Lys Asp Gln Lys Tyr Ser Phe Leu His Asp 
        35                  40                  45              


Ser Gln Thr Ser Phe Ser Phe Ser Asp Ser Ile Pro Thr Pro Ser Asn 
    50                  55                  60                  


Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
65                  70                  75                  80  


Leu Leu Leu Ile Glu Ser Trp Leu Glu Pro Val Arg Phe Leu Arg Ser 
                85                  90                  95      


Met Phe Ala Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
            100                 105                 110         


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg 
        115                 120                 125             


Leu Glu Asp Gly Ser Pro Arg 
    130                 135 


<210>  7
<211>  192
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  7

Met Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu 
1               5                   10                  15      


Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe 
            20                  25                  30          


Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn 
        35                  40                  45              


Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn 
    50                  55                  60                  


Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
65                  70                  75                  80  


Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser 
                85                  90                  95      


Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr 
            100                 105                 110         


Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg 
        115                 120                 125             


Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr 
    130                 135                 140                 


Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn 
145                 150                 155                 160 


Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
                165                 170                 175     


Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190         


<210>  8
<211>  134
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  8

Met Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu 
1               5                   10                  15      


Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe 
            20                  25                  30          


Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn 
        35                  40                  45              


Pro Gln Thr Ser Leu Ser Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn 
    50                  55                  60                  


Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
65                  70                  75                  80  


Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser 
                85                  90                  95      


Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr 
            100                 105                 110         


Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg 
        115                 120                 125             


Leu Glu Asp Gly Ser Pro 
    130                 


<210>  9
<211>  192
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  9

Met Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu 
1               5                   10                  15      


Arg Ala Arg Arg Leu Tyr Gln Leu Ala Tyr Asp Thr Tyr Gln Glu Phe 
            20                  25                  30          


Glu Glu Ala Tyr Ile Leu Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn 
        35                  40                  45              


Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn 
    50                  55                  60                  


Arg Val Lys Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
65                  70                  75                  80  


Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Leu Leu Arg Ser 
                85                  90                  95      


Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr 
            100                 105                 110         


Arg His Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Trp Arg 
        115                 120                 125             


Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Asn Gln Ser Tyr 
    130                 135                 140                 


Ser Lys Phe Asp Thr Lys Ser His Asn Asp Asp Ala Leu Leu Lys Asn 
145                 150                 155                 160 


Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
                165                 170                 175     


Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190         


<210>  10
<211>  135
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  10

Met Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu 
1               5                   10                  15      


Arg Ala Arg Arg Leu Tyr Gln Leu Ala Tyr Asp Thr Tyr Gln Glu Phe 
            20                  25                  30          


Glu Glu Ala Tyr Ile Leu Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn 
        35                  40                  45              


Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn 
    50                  55                  60                  


Arg Val Lys Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
65                  70                  75                  80  


Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Leu Leu Arg Ser 
                85                  90                  95      


Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr 
            100                 105                 110         


Arg His Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Trp Arg 
        115                 120                 125             


Leu Glu Asp Gly Ser Pro Arg 
    130                 135 


<210>  11
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Leu, Phe

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Arg, Ser

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Ile, Leu

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Ser, Ile

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Leu, Val

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Leu, Ser

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Leu, Ile

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Ile, Leu

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Gln, Glu, Arg

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Leu, Asn

<400>  11

Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Trp Xaa Glu 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  12

Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  13

Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp Leu Glu 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  14

Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu 
1               5                   10                  


<210>  15
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  15

Leu Leu Arg Ile Ser Leu 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  16

Arg Ile Ser Leu Leu Leu 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  17

Ser Leu Leu Leu Ile Gln 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  18

Leu Leu Ile Gln Ser Trp 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  19

Ile Gln Ser Trp Leu Glu 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  20

Ser Leu Leu Leu Ile Glu 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  21

Leu Leu Ile Glu Ser Trp 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  22

Ile Glu Ser Trp Leu Glu 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  23

Phe Leu Ser Leu Ile Val 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  24

Ser Leu Ile Val Ser Ile 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  25

Ile Val Ser Ile Leu Arg 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  26

Ser Ile Leu Arg Ser Trp 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  27

Leu Arg Ser Trp Asn Glu 
1               5       


<210>  28
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  28

Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
1               5                   10                  15      


Phe Ala Asn Ser 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  29

Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
1               5                   10                  15      


Leu Glu Pro Val 
            20  


<210>  30
<211>  37
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  30

Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp 
1               5                   10                  15      


Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu 
            20                  25                  30          


Ala Pro Glu Ala Ile 
        35          


<210>  31
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  31

Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu 
1               5                   10                  15      


Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
            20                  25                  


<210>  32
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  32

Leu Ser Gln Ile Leu Ser Ser Leu Ile Gln Ser Trp Leu Glu 
1               5                   10                  


<210>  33
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  33

Phe Asn Ser Leu Ile Ser Ser Ile Leu Arg Val Trp Leu Glu 
1               5                   10                  


<210>  34
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  34

Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu 
1               5                   10                  15      


Arg 
    


<210>  35
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic RNA

<400>  35
ccgauuuacu gaagaauugc acaga                                           25


<210>  36
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic RNA

<400>  36
gaauguaacc uaauagaacc cuaau                                           25


