                         SEQUENCE LISTING

<110>  Advaxis
       THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
 
<120>  LIVE LISTERIA-BASED VACCINES FOR CENTRAL NERVOUS SYSTEM THERAPY

<130>  P-73609-PC

<140>  PCT/US11/999999
<141>  2011-02-15

<150>  61/304,701
<151>  2010-02-15

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  1329
<212>  DNA
<213>  Listeria monocytogenes

<400>  1
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag caaaggatgc atctgcattc aataaagaaa attcaatttc atccatggca      120

ccaccagcat ctccgcctgc aagtcctaag acgccaatcg aaaagaaaca cgcggatgaa      180

atcgataagt atatacaagg attggattac aataaaaaca atgtattagt ataccacgga      240

gatgcagtga caaatgtgcc gccaagaaaa ggttacaaag atggaaatga atatattgtt      300

gtggagaaaa agaagaaatc catcaatcaa aataatgcag acattcaagt tgtgaatgca      360

atttcgagcc taacctatcc aggtgctctc gtaaaagcga attcggaatt agtagaaaat      420

caaccagatg ttctccctgt aaaacgtgat tcattaacac tcagcattga tttgccaggt      480

atgactaatc aagacaataa aatagttgta aaaaatgcca ctaaatcaaa cgttaacaac      540

gcagtaaata cattagtgga aagatggaat gaaaaatatg ctcaagctta tccaaatgta      600

agtgcaaaaa ttgattatga tgacgaaatg gcttacagtg aatcacaatt aattgcgaaa      660

tttggtacag catttaaagc tgtaaataat agcttgaatg taaacttcgg cgcaatcagt      720

gaagggaaaa tgcaagaaga agtcattagt tttaaacaaa tttactataa cgtgaatgtt      780

aatgaaccta caagaccttc cagatttttc ggcaaagctg ttactaaaga gcagttgcaa      840

gcgcttggag tgaatgcaga aaatcctcct gcatatatct caagtgtggc gtatggccgt      900

caagtttatt tgaaattatc aactaattcc catagtacta aagtaaaagc tgcttttgat      960

gctgccgtaa gcggaaaatc tgtctcaggt gatgtagaac taacaaatat catcaaaaat     1020

tcttccttca aagccgtaat ttacggaggt tccgcaaaag atgaagttca aatcatcgac     1080

ggcaacctcg gagacttacg cgatattttg aaaaaaggcg ctacttttaa tcgagaaaca     1140

ccaggagttc ccattgctta tacaacaaac ttcctaaaag acaatgaatt agctgttatt     1200

aaaaacaact cagaatatat tgaaacaact tcaaaagctt atacagatgg aaaaattaac     1260

atcgatcact ctggaggata cgttgctcaa ttcaacattt cttgggatga agtaaattat     1320

gatctcgag                                                             1329


<210>  2
<211>  442
<212>  PRT
<213>  Listeria monocytogenes

<400>  2

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Leu 
        435                 440         


<210>  3
<211>  14
<212>  PRT
<213>  Listeria monocytogenes

<400>  3

Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg 
1               5                   10                  


<210>  4
<211>  28
<212>  PRT
<213>  Listeria monocytogenes

<400>  4

Lys Ala Ser Val Thr Asp Thr Ser Glu Gly Asp Leu Asp Ser Ser Met 
1               5                   10                  15      


Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
            20                  25              


<210>  5
<211>  20
<212>  PRT
<213>  Listeria monocytogenes

<400>  5

Lys Asn Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro Thr Asp 
1               5                   10                  15      


Glu Glu Leu Arg 
            20  


<210>  6
<211>  33
<212>  PRT
<213>  Listeria monocytogenes

<400>  6

Arg Gly Gly Ile Pro Thr Ser Glu Glu Phe Ser Ser Leu Asn Ser Gly 
1               5                   10                  15      


Asp Phe Thr Asp Asp Glu Asn Ser Glu Thr Thr Glu Glu Glu Ile Asp 
            20                  25                  30          


Arg 
    


<210>  7
<211>  17
<212>  PRT
<213>  Streptococcus pyogenes

<400>  7

Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  8
<211>  17
<212>  PRT
<213>  Streptococcus equisimilis

<400>  8

Lys Gln Asn Thr Ala Asn Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  9
<211>  98
<212>  PRT
<213>  Human papillomavirus type 16

<400>  9

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  10
<211>  105
<212>  PRT
<213>  Human papillomavirus type 16

<400>  10

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E7 antigen

<400>  11

Thr Leu Gly Ile Val Cys Pro Ile 
1               5               


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E7 antigen

<400>  12

Leu Leu Met Gly Thr Leu Gly Ile Val 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E7 antigen

<400>  13

Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   10  


<210>  14
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  15
<211>  158
<212>  PRT
<213>  Human papillomavirus type 16

<400>  15

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210>  16
<211>  158
<212>  PRT
<213>  Human papillomavirus type 18

<400>  16

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  17
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Her-2 chimeric protein

<400>  17
acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg       60

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      120

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      180

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      240

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      300

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      360

ctctgctacc aggacacgat tttgtggaag aatatccagg agtttgctgg ctgcaagaag      420

atctttggga gcctggcatt tctgccggag agctttgatg gggacccagc ctccaacact      480

gccccgctcc agccagagca gctccaagtg tttgagactc tggaagagat cacaggttac      540

ctatacatct cagcatggcc ggacagcctg cctgacctca gcgtcttcca gaacctgcaa      600

gtaatccggg gacgaattct gcacaatggc gcctactcgc tgaccctgca agggctgggc      660

atcagctggc tggggctgcg ctcactgagg gaactgggca gtggactggc cctcatccac      720

cataacaccc acctctgctt cgtgcacacg gtgccctggg accagctctt tcggaacccg      780

caccaagctc tgctccacac tgccaaccgg ccagaggacg agtgtgtggg cgagggcctg      840

gcctgccacc agctgtgcgc ccgagggcag cagaagatcc ggaagtacac gatgcggaga      900

ctgctgcagg aaacggagct ggtggagccg ctgacaccta gcggagcgat gcccaaccag      960

gcgcagatgc ggatcctgaa agagacggag ctgaggaagg tgaaggtgct tggatctggc     1020

gcttttggca cagtctacaa gggcatctgg atccctgatg gggagaatgt gaaaattcca     1080

gtggccatca aagtgttgag ggaaaacaca tcccccaaag ccaacaaaga aatcttagac     1140

gaagcatacg tgatggctgg tgtgggctcc ccatatgtct cccgccttct gggcatctgc     1200

ctgacatcca cggtgcagct ggtgacacag cttatgccct atggctgcct cttagactaa     1260


<210>  18
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Her-2 chimeric protein

<400>  18

Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln Val 
1               5                   10                  15      


Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu 
            20                  25                  30          


Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile Ala 
        35                  40                  45              


His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg 
    50                  55                  60                  


Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn 
65                  70                  75                  80  


Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro Gly 
                85                  90                  95      


Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly 
            100                 105                 110         


Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile 
        115                 120                 125             


Leu Trp Lys Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly 
    130                 135                 140                 


Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn 
145                 150                 155                 160 


Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu 
                165                 170                 175     


Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro 
            180                 185                 190         


Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu 
        195                 200                 205             


His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp 
    210                 215                 220                 


Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile 
225                 230                 235                 240 


His His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln 
                245                 250                 255     


Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro 
            260                 265                 270         


Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala 
        275                 280                 285             


Arg Gly Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln 
    290                 295                 300                 


Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro Asn 
305                 310                 315                 320 


Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val Lys 
                325                 330                 335     


Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile 
            340                 345                 350         


Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu Arg 
        355                 360                 365             


Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr 
    370                 375                 380                 


Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile 
385                 390                 395                 400 


Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr Gly 
                405                 410                 415     


Cys Leu Leu Asp 
            420 


<210>  19
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Gln Ala Ser Ser Gly Gln Ala Arg Met Phe Pro Asn Ala Pro Tyr 
1               5                   10                  15      


Leu Pro Ser Cys Leu Glu Ser Gln Pro Ala Ile Arg Asn Gln Gly Tyr 
            20                  25                  30          


Ser Thr Val Thr Phe Asp Gln Thr Pro Ser Tyr Gly His Thr Pro Ser 
        35                  40                  45              


His His Ala Ala Gln Phe Pro Asn His Ser Phe Lys His Glu Asp Pro 
    50                  55                  60                  


Met Gly Gln Gln Gly Ser Leu Gly Glu Gln Gln Tyr Ser Val Pro Pro 
65                  70                  75                  80  


Pro Val Tyr Gly Cys His Thr Pro Thr Asp Ser Cys Thr Gly Ser Gln 
                85                  90                  95      


Ala Leu Leu Leu Arg Thr Pro Tyr Ser Ser Asp Asn Leu Tyr Gln Met 
            100                 105                 110         


Thr Ser Gln Leu Glu Cys Met Thr Trp Asn Gln Met Asn Leu Gly Ala 
        115                 120                 125             


Thr Leu Lys Gly Val Ala Ala Gly Ser Ser Ser Ser Val Lys Trp Thr 
    130                 135                 140                 


Glu Gly Gln Ser Asn His Ser Thr Gly Tyr Glu Ser Asp Asn His Thr 
145                 150                 155                 160 


Thr Pro Ile Leu Cys Gly Ala Gln Tyr Arg Ile His Thr His Gly Val 
                165                 170                 175     


Phe Arg Gly Ile Gly Asp Val Arg Arg Val Pro Gly Val Ala Pro Thr 
            180                 185                 190         


Leu Val Arg Ser Ala Ser Glu Thr Ser Glu Lys Arg Pro Phe Met Cys 
        195                 200                 205             


Ala Tyr Pro Gly Cys Asn Lys Arg Tyr Phe Lys Leu Ser His Leu Gln 
    210                 215                 220                 


Met His Ser Arg Lys His Thr Gly Glu Lys Pro Tyr Gln Cys Asp Phe 
225                 230                 235                 240 


Lys Asp Cys Glu Arg Arg Phe Ser Arg Ser Asp Gln Leu Lys Arg His 
                245                 250                 255     


Gln Arg Arg His Thr Gly Val Lys Pro Phe Gln Cys Lys Thr Cys Gln 
            260                 265                 270         


Arg Lys Phe Ser Arg Ser Asp His Leu Lys Thr His Thr Arg Thr His 
        275                 280                 285             


Thr Gly Lys Thr Ser Glu Lys Pro Phe Ser Cys Arg Trp Pro Ser Cys 
    290                 295                 300                 


Gln Lys Lys Phe Ala Arg Ser Asp Glu Leu Val Arg His His Asn Met 
305                 310                 315                 320 


His Gln Arg Asn Met Thr Lys Leu Gln Leu Ala Leu 
                325                 330         


<210>  20
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile Ser 
1               5                   10                  15      


Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val Asn 
            20                  25                  30          


Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr Leu 
        35                  40                  45              


Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu Cys 
    50                  55                  60                  


Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr Trp 
65                  70                  75                  80  


Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp Leu 
                85                  90                  95      


Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln Cys 
            100                 105                 110         


Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr Trp 
        115                 120                 125             


Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp Cys 
    130                 135                 140                 


Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly Ile 
145                 150                 155                 160 


Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu Gly 
                165                 170                 175     


Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile 
            180                 185         


<210>  21
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gln Gln Asn 
1               5                   10                  15      


Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys Asp Phe 
            20                  25                  30          


Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg Ser Ser 
        35                  40                  45              


Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro Pro Val 
    50                  55                  60                  


Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu Lys Trp 
65                  70                  75                  80  


Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr Glu Ile 
                85                  90                  95      


Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val Glu Asn 
            100                 105                 110         


Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gly Leu Cys Phe 
        115                 120                 125             


Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly Ile Trp 
    130                 135                 140                 


Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu Ser Lys 
145                 150                 155                 160 


Lys Thr Leu Leu Arg Phe Ala Leu Pro Phe Gly Phe Ile Leu Val Leu 
                165                 170                 175     


Val Ile Phe Val Thr Gly Leu Leu 
            180                 


<210>  22
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp His 
1               5                   10                  15      


Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala Cys 
            20                  25                  30          


Ala Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr Glu 
        35                  40                  45              


Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu Glu 
    50                  55                  60                  


Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His Ser 
65                  70                  75                  80  


Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu Thr 
                85                  90                  95      


Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys Ile 
            100                 105                 110         


Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala Lys 
        115                 120                 125             


Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140     


<210>  23
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Ala Pro Ala Leu Pro Gln Ile Trp Gln Leu Tyr Leu Lys Asn Tyr 
1               5                   10                  15      


Arg Ile Ala Thr Phe Lys Asn Trp Pro Phe Leu Glu Asp Cys Ala Cys 
            20                  25                  30          


Ala Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr Glu 
        35                  40                  45              


Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu Glu 
    50                  55                  60                  


Gly Trp Glu Pro Asp Asp Asn Pro Ile Glu Glu His Arg Lys His Ser 
65                  70                  75                  80  


Pro Gly Cys Ala Phe Leu Thr Val Lys Lys Gln Met Glu Glu Leu Thr 
                85                  90                  95      


Val Ser Glu Phe Leu Lys Leu Asp Arg Gln Arg Ala Lys Asn Lys Ile 
            100                 105                 110         


Ala Lys Glu Thr Asn Asn Lys Gln Lys Glu Phe Glu Glu Thr Ala Lys 
        115                 120                 125             


Thr Thr Arg Gln Ser Ile Glu Gln Leu Ala Ala 
    130                 135                 


<210>  24
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro Leu Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp Leu Pro Ser Glu Glu 
            20                  25                  30          


Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu Glu Asp Leu Pro Gly 
        35                  40                  45              


Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Glu Val Lys Pro Lys 
    50                  55                  60                  


Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp Leu Pro Thr Val Glu 
65                  70                  75                  80  


Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn Ala His Arg Asp Lys 
                85                  90                  95      


Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly Gly Asp Pro Pro Trp 
            100                 105                 110         


Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe Gln Ser Pro Val Asp 
        115                 120                 125             


Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala Leu Arg Pro Leu Glu 
    130                 135                 140                 


Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu Leu Arg Leu Arg Asn 
145                 150                 155                 160 


Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro Gly Leu Glu Met Ala 
                165                 170                 175     


Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln Leu His Leu His Trp 
            180                 185                 190         


Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr Val Glu Gly His Arg 
        195                 200                 205             


Phe Pro Ala Glu Ile His Val Val His Leu Ser Thr Ala Phe Ala Arg 
    210                 215                 220                 


Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu Ala Val Leu Ala Ala 
225                 230                 235                 240 


Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala Tyr Glu Gln Leu Leu 
                245                 250                 255     


Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser Glu Thr Gln Val Pro 
            260                 265                 270         


Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp Phe Ser Arg Tyr Phe 
        275                 280                 285             


Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys Ala Gln Gly Val Ile 
    290                 295                 300                 


Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser Ala Lys Gln Leu His 
305                 310                 315                 320 


Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp Ser Arg Leu Gln Leu 
                325                 330                 335     


Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg Val Ile Glu Ala Ser 
            340                 345                 350         


Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala Ala Glu Pro Val Gln 
        355                 360                 365             


Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu Ala Leu Val Phe Gly 
    370                 375                 380                 


Leu Leu 
385     


<210>  25
<211>  366
<212>  PRT
<213>  Mus musculus

<400>  25

Gln Gly Leu Ser Gly Met Gln Gly Glu Pro Ser Leu Gly Asp Ser Ser 
1               5                   10                  15      


Ser Gly Glu Asp Glu Leu Gly Val Asp Val Leu Pro Ser Glu Glu Asp 
            20                  25                  30          


Ala Pro Glu Glu Ala Asp Pro Pro Asp Gly Glu Asp Pro Pro Glu Val 
        35                  40                  45              


Asn Ser Glu Asp Arg Met Glu Glu Ser Leu Gly Leu Glu Asp Leu Ser 
    50                  55                  60                  


Thr Pro Glu Ala Pro Glu His Ser Gln Gly Ser His Gly Asp Glu Lys 
65                  70                  75                  80  


Gly Gly Gly His Ser His Trp Ser Tyr Gly Gly Thr Leu Leu Trp Pro 
                85                  90                  95      


Gln Val Ser Pro Ala Cys Ala Gly Arg Phe Gln Ser Pro Val Asp Ile 
            100                 105                 110         


Arg Leu Glu Arg Thr Ala Phe Cys Arg Thr Leu Gln Pro Leu Glu Leu 
        115                 120                 125             


Leu Gly Tyr Glu Leu Gln Pro Leu Pro Glu Leu Ser Leu Ser Asn Asn 
    130                 135                 140                 


Gly His Thr Val Gln Leu Thr Leu Pro Pro Gly Leu Lys Met Ala Leu 
145                 150                 155                 160 


Gly Pro Gly Gln Glu Tyr Arg Ala Leu Gln Leu His Leu His Trp Gly 
                165                 170                 175     


Thr Ser Asp His Pro Gly Ser Glu His Thr Val Asn Gly His Arg Phe 
            180                 185                 190         


Pro Ala Glu Ile His Val Val His Leu Ser Thr Ala Phe Ser Glu Leu 
        195                 200                 205             


His Glu Ala Leu Gly Arg Pro Gly Gly Leu Ala Val Leu Ala Ala Phe 
    210                 215                 220                 


Leu Gln Glu Ser Pro Glu Glu Asn Ser Ala Tyr Glu Gln Leu Leu Ser 
225                 230                 235                 240 


His Leu Glu Glu Ile Ser Glu Glu Gly Ser Lys Ile Glu Ile Pro Gly 
                245                 250                 255     


Leu Asp Val Ser Ala Leu Leu Pro Ser Asp Leu Ser Arg Tyr Tyr Arg 
            260                 265                 270         


Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys Ser Gln Gly Val Ile Trp 
        275                 280                 285             


Thr Val Phe Asn Glu Thr Val Lys Leu Ser Ala Lys Gln Leu His Thr 
    290                 295                 300                 


Leu Ser Val Ser Leu Trp Gly Pro Arg Asp Ser Arg Leu Gln Leu Asn 
305                 310                 315                 320 


Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg Thr Ile Glu Ala Ser Phe 
                325                 330                 335     


Pro Ala Ala Glu Asp Ser Ser Pro Glu Pro Val His Val Asn Ser Cys 
            340                 345                 350         


Phe Thr Ala Gly Asp Ile Leu Ala Leu Val Phe Gly Leu Leu 
        355                 360                 365     


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT1 peptide

<400>  26

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mapped HLA-A2 restricted epitopes located at the extracellular 
       domains of the Her2/neu molecule

<400>  27

His Leu Tyr Gln Gly Cys Gln Val Val 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mapped HLA-A2 restricted epitopes located at the extracellular 
       domains of the Her2/neu molecule

<400>  28

Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mapped HLA-A2 restricted epitopes located at the intracellular 
       domains of the Her2/neu molecule

<400>  29

Arg Leu Leu Gln Glu Thr Glu Leu Val 
1               5                   


