                               SEQUENCE LISTING	

<110> ALEXION PHARMACEUTICALS, INC.
 
<120> THERAPEUTIC AND DIAGNOSTIC METHODS USING ANTI-CD200 ANTIBODIES

<130> ALXN-152-WO1

<140>
<141>

<150> 61/337,962
<151> 2010-02-11

<160> 42    

<170> PatentIn version 3.5

<210> 1
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Glu Pro 
            260                 265                 


<210> 2
<211> 294
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Arg Leu Thr Leu Thr Arg Thr Ile Gly Gly Pro Leu Leu Thr 
1               5                   10                  15      


Ala Thr Leu Leu Gly Lys Thr Thr Ile Asn Asp Tyr Gln Val Ile Arg 
            20                  25                  30          


Met Pro Phe Ser His Leu Ser Thr Tyr Ser Leu Val Trp Val Met Ala 
        35                  40                  45              


Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu 
    50                  55                  60                  


Arg Glu Gln Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn 
65                  70                  75                  80  


Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala Val Ser 
                85                  90                  95      


Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln 
            100                 105                 110         


Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn 
        115                 120                 125             


Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr 
    130                 135                 140                 


Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala 
145                 150                 155                 160 


Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe 
                165                 170                 175     


Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala 
            180                 185                 190         


Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr 
        195                 200                 205             


Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu 
    210                 215                 220                 


His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val Ile Cys Gln 
225                 230                 235                 240 


Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys 
                245                 250                 255     


Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Leu Val 
            260                 265                 270         


Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg 
        275                 280                 285             


Asn Gln Asp Arg Glu Pro 
    290                 


<210> 3
<211> 274
<212> PRT
<213> Homo sapiens

<400> 3
Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr Ser Leu Val Trp 
1               5                   10                  15      


Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr 
            20                  25                  30          


Gln Asp Glu Arg Glu Gln Leu Tyr Thr Thr Ala Ser Leu Lys Cys Ser 
        35                  40                  45              


Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys 
    50                  55                  60                  


Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val 
65                  70                  75                  80  


Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly 
                85                  90                  95      


Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu 
            100                 105                 110         


Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser 
        115                 120                 125             


Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His 
    130                 135                 140                 


Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala 
145                 150                 155                 160 


Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu 
                165                 170                 175     


Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr 
            180                 185                 190         


Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val 
        195                 200                 205             


Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr 
    210                 215                 220                 


Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val 
225                 230                 235                 240 


Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys 
                245                 250                 255     


Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln Gly Val Gln Lys 
            260                 265                 270         


Met Thr 
        


<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Phe Thr Phe Ser Gly Phe Ala Met Ser 
1               5                   10  


<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Leu Asp Ser Val Lys Gly 
1               5                   10                  15      


<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gly Asn Tyr Tyr Ser Gly Thr Ser Tyr Asp Tyr 
1               5                   10      


<210> 7
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Gln Gln Ser Asn Glu Asp Pro Arg Thr 
1               5                   


<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   10  


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Trp Ile Asp Pro Glu Asn Gly Asp Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Lys Asn Tyr Tyr Val Ser Asn Tyr Asn Phe Phe Asp Val 
1               5                   10              


<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Ser Ala Ser Ser Ser Val Arg Tyr Met Tyr 
1               5                   10  


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
1               5                   


<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His 
1               5                   10  


<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Trp Ile Asp Pro Glu Ile Gly Ala Thr Lys Tyr Val Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Leu Tyr Gly Asn Tyr Asp Arg Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Lys Ala Ser Gln Asn Val Arg Thr Ala Val Ala 
1               5                   10      


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Leu Ala Ser Asn Arg His Thr 
1               5           


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Leu Gln His Trp Asn Tyr Pro Leu Thr 
1               5                   


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Gly Tyr Ser Phe Thr Asp Tyr Ile Ile Leu 
1               5                   10  


<210> 23
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
His Ile Asp Pro Tyr Tyr Gly Ser Ser Asn Tyr Asn Leu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Ser Lys Arg Asp Tyr Phe Asp Tyr 
1               5               


<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Arg Ala Asn Arg Leu Val Asp 
1               5           


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gly Tyr Thr Phe Thr Glu Tyr Thr Met His 
1               5                   10  


<210> 29
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Val Asn Pro Asn Asn Gly Gly Ala Leu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 30
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Arg Ser Asn Tyr Arg Tyr Asp Asp Ala Met Asp Tyr 
1               5                   10          


<210> 31
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Lys Ser Ser Gln Ser Leu Leu Asp Ile Asp Glu Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Leu Val Ser Lys Leu Asp Ser 
1               5           


<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Ala Phe Asn Ile Lys Asp His Tyr Met His 
1               5                   10  


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Trp Ile Asp Pro Glu Ser Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Phe Asn Gly Tyr Gln Ala Leu Asp Gln 
1               5                   


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210> 38
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210> 39
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Arg Gln Tyr His Arg Ser Pro Pro Ile Phe Thr 
1               5                   10      


<210> 40
<211> 297
<212> PRT
<213> Homo sapiens

<400> 40
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210> 41
<211> 9
<212> PRT
<213> Homo sapiens

<400> 41
Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
1               5                   


<210> 42
<211> 47
<212> PRT
<213> Homo sapiens

<400> 42
Asn Ile Lys Ile Ser His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile 
1               5                   10                  15      


Arg Ala His Thr Pro Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn 
            20                  25                  30          


Pro Ser Glu Lys Asn Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile 
        35                  40                  45          


