                         SEQUENCE LISTING

<110>  CABIROL, Fabien
       COLLIER, Steven J.
       DAUSSMANN, Thomas
       MODUKURU, Naga
 
<120>  PROCESS USING AMINO ACID DEHYDROGENASE AND KETOREDUCTASE COFACTOR
        REGENERATING SYSTEM

<130>  CX2-038USP1

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  1
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  2
<211>  263
<212>  PRT
<213>  Novosphingobium aromaticivorans

<400>  2

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  3
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  3
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttttccagcg tcgtgggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  4
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  4

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Val Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  5
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  5
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcggggatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  6
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  6

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Gly Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  7
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  7
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggctcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  8
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  8

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ser Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  9
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  9
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcatt gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  10
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  10

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ile Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  11
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  11
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcggggggct gcgcggctgg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  12
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  12

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Trp Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  13
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  13
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcccg atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  14
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  14

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Pro Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  15
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  15
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggccag atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  16
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  16

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gln Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  17
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  17
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcgtt atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  18
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  18

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Val Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  19
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  19
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtact ttgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  20
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  20

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Phe Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  21
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  21
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcgatcatg      600

gacaagtact ttgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  22
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  22

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Met Asp Lys Tyr Phe Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  23
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  23
atgccgcttg aaatgacgat tgctctcaac aatgtggtcg ccgtcgtcac cggcgcggcg       60

ggaggcatcg gccgcgaact ggtcaaggcg atgaaggccg ccaacgccat cgtcatcgcc      120

accgacatgg cgccctcggc cgatgtcgaa ggcgcggacc attatctcca gcacgacgtg      180

acgagcgagg ccggctggaa ggcggtcgcg gcgctggccc aggaaaagta cgggcgcgtc      240

gatgcgctgg tgcacaacgc gggcatctcg atcgtcacga agttcgaaga cactccgctg      300

tccgatttcc accgcgtgaa cacggtcaac gtcgattcca tcatcatcgg tacgcaggtc      360

ctgctgccgc tgctcaagga aggcggcaag gcgcgcgcag ggggcgcctc ggtggtcaac      420

ttctccagcg tcgggggtct gcgcggcgcg gcgttcaatg cggcctattg caccagcaag      480

gcggcggtga agatgctctc gaagtgcctc ggcgcggaat tcgcggcgct cggctacaac      540

atccgcgtca actccgtgca tccgggcggc atcgataccc cgatgctcgg ctcgatcatt      600

gacaagtacg tcgaactcgg cgctgccccc tcgcgcgagg tggcccaggc cgcgatggaa      660

atgcgccacc cgatcggtcg catgggtcgc cctgccgaaa tgggcggcgg cgtggtctat      720

ctctgctccg acgcagcaag cttcgtcacc tgcacggaat tcgtgatgga cggcggcttc      780

agccaggtct ga                                                          792


<210>  24
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of ketoreductase from Novosphingobium aromaticivorans

<400>  24

Met Pro Leu Glu Met Thr Ile Ala Leu Asn Asn Val Val Ala Val Val 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Ile Gly Arg Glu Leu Val Lys Ala Met Lys 
            20                  25                  30          


Ala Ala Asn Ala Ile Val Ile Ala Thr Asp Met Ala Pro Ser Ala Asp 
        35                  40                  45              


Val Glu Gly Ala Asp His Tyr Leu Gln His Asp Val Thr Ser Glu Ala 
    50                  55                  60                  


Gly Trp Lys Ala Val Ala Ala Leu Ala Gln Glu Lys Tyr Gly Arg Val 
65                  70                  75                  80  


Asp Ala Leu Val His Asn Ala Gly Ile Ser Ile Val Thr Lys Phe Glu 
                85                  90                  95      


Asp Thr Pro Leu Ser Asp Phe His Arg Val Asn Thr Val Asn Val Asp 
            100                 105                 110         


Ser Ile Ile Ile Gly Thr Gln Val Leu Leu Pro Leu Leu Lys Glu Gly 
        115                 120                 125             


Gly Lys Ala Arg Ala Gly Gly Ala Ser Val Val Asn Phe Ser Ser Val 
    130                 135                 140                 


Gly Gly Leu Arg Gly Ala Ala Phe Asn Ala Ala Tyr Cys Thr Ser Lys 
145                 150                 155                 160 


Ala Ala Val Lys Met Leu Ser Lys Cys Leu Gly Ala Glu Phe Ala Ala 
                165                 170                 175     


Leu Gly Tyr Asn Ile Arg Val Asn Ser Val His Pro Gly Gly Ile Asp 
            180                 185                 190         


Thr Pro Met Leu Gly Ser Ile Ile Asp Lys Tyr Val Glu Leu Gly Ala 
        195                 200                 205             


Ala Pro Ser Arg Glu Val Ala Gln Ala Ala Met Glu Met Arg His Pro 
    210                 215                 220                 


Ile Gly Arg Met Gly Arg Pro Ala Glu Met Gly Gly Gly Val Val Tyr 
225                 230                 235                 240 


Leu Cys Ser Asp Ala Ala Ser Phe Val Thr Cys Thr Glu Phe Val Met 
                245                 250                 255     


Asp Gly Gly Phe Ser Gln Val 
            260             


<210>  25
<211>  1104
<212>  DNA
<213>  Geobacillus stearothermophilus

<400>  25
atggaattgt tcaaatatat ggaaacttac gattatgagc aagtgctgtt ttgccaagat       60

aaagaatcgg gtttgaaagc gatcattgcc attcatgaca caacgctcgg cccggcgctc      120

ggcgggacgc gcatgtggat gtacaattcg gaagaagaag cgcttgaaga cgccttgcgc      180

ctcgcccgcg gcatgacgta caaaaacgcg gccgccggcc tcaacttggg cgggggcaaa      240

acggtcatca tcggcgaccc gcgcaaagat aaaaacgaag cgatgttccg ggcgttcggc      300

cgcttcattc aagggctgaa cggccgctac atcacggcgg aagacgtcgg cacgaccgtc      360

gccgatatgg atatcatcta tcaagaaacc gactatgtca ccggcatttc gcccgaattc      420

ggctcatccg gcaacccatc gccggcgacc gcctacggcg tataccgcgg catgaaggcg      480

gcggcaaaag aggcgttcgg cagcgattcg ctcgaaggaa aagtcgtcgc cgtccaagga      540

gtcggcaatg tcgcgtatca tttgtgccgc catttgcacg aagaaggagc gaaactcatc      600

gtgactgaca tcaacaagga agtggtggcg cgcgcggtcg aggaattcgg agcgaaagcg      660

gtcgacccga acgacattta cggcgtggag tgcgacattt ttgctccatg cgcgctcggc      720

ggcatcatca acgatcaaac gattccgcaa ctgaaagcga aagtgatcgc cggatcggcg      780

aacaaccagc tgaaagagcc gcgccatggc gacatcatcc atgaaatggg catcgtctat      840

gccccggatt atgtgatcaa cgccggcggc gtcatcaacg tcgcggacga actgtacggc      900

tacaatcggg aacgggcgat gaaaaaaatc gagcaaattt atgacaacat cgaaaaagtg      960

tttgccatcg ccaagcgcga caacattcca acgtatgtgg ccgccgaccg gatggcggaa     1020

gaacggattg aaacgatgcg caaagcgcgc agtcaatttt tgcaaaatgg tcaccatatt     1080

ttaagccgcc gtcgcgcccg ctaa                                            1104


<210>  26
<211>  367
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  26

Met Glu Leu Phe Lys Tyr Met Glu Thr Tyr Asp Tyr Glu Gln Val Leu 
1               5                   10                  15      


Phe Cys Gln Asp Lys Glu Ser Gly Leu Lys Ala Ile Ile Ala Ile His 
            20                  25                  30          


Asp Thr Thr Leu Gly Pro Ala Leu Gly Gly Thr Arg Met Trp Met Tyr 
        35                  40                  45              


Asn Ser Glu Glu Glu Ala Leu Glu Asp Ala Leu Arg Leu Ala Arg Gly 
    50                  55                  60                  


Met Thr Tyr Lys Asn Ala Ala Ala Gly Leu Asn Leu Gly Gly Gly Lys 
65                  70                  75                  80  


Thr Val Ile Ile Gly Asp Pro Arg Lys Asp Lys Asn Glu Ala Met Phe 
                85                  90                  95      


Arg Ala Phe Gly Arg Phe Ile Gln Gly Leu Asn Gly Arg Tyr Ile Thr 
            100                 105                 110         


Ala Glu Asp Val Gly Thr Thr Val Ala Asp Met Asp Ile Ile Tyr Gln 
        115                 120                 125             


Glu Thr Asp Tyr Val Thr Gly Ile Ser Pro Glu Phe Gly Ser Ser Gly 
    130                 135                 140                 


Asn Pro Ser Pro Ala Thr Ala Tyr Gly Val Tyr Arg Gly Met Lys Ala 
145                 150                 155                 160 


Ala Ala Lys Glu Ala Phe Gly Ser Asp Ser Leu Glu Gly Lys Val Val 
                165                 170                 175     


Ala Val Gln Gly Val Gly Asn Val Ala Tyr His Leu Cys Arg His Leu 
            180                 185                 190         


His Glu Glu Gly Ala Lys Leu Ile Val Thr Asp Ile Asn Lys Glu Val 
        195                 200                 205             


Val Ala Arg Ala Val Glu Glu Phe Gly Ala Lys Ala Val Asp Pro Asn 
    210                 215                 220                 


Asp Ile Tyr Gly Val Glu Cys Asp Ile Phe Ala Pro Cys Ala Leu Gly 
225                 230                 235                 240 


Gly Ile Ile Asn Asp Gln Thr Ile Pro Gln Leu Lys Ala Lys Val Ile 
                245                 250                 255     


Ala Gly Ser Ala Asn Asn Gln Leu Lys Glu Pro Arg His Gly Asp Ile 
            260                 265                 270         


Ile His Glu Met Gly Ile Val Tyr Ala Pro Asp Tyr Val Ile Asn Ala 
        275                 280                 285             


Gly Gly Val Ile Asn Val Ala Asp Glu Leu Tyr Gly Tyr Asn Arg Glu 
    290                 295                 300                 


Arg Ala Met Lys Lys Ile Glu Gln Ile Tyr Asp Asn Ile Glu Lys Val 
305                 310                 315                 320 


Phe Ala Ile Ala Lys Arg Asp Asn Ile Pro Thr Tyr Val Ala Ala Asp 
                325                 330                 335     


Arg Met Ala Glu Glu Arg Ile Glu Thr Met Arg Lys Ala Arg Ser Gln 
            340                 345                 350         


Phe Leu Gln Asn Gly His His Ile Leu Ser Arg Arg Arg Ala Arg 
        355                 360                 365         


