                         SEQUENCE LISTING

<110>  The University of Nottingham
 
<120>  Methods

<130>  JA52687P.WOP

<150>  GB1002409.9
<151>  2010 02 12

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  2
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  3
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro 
                85                  90                  95      


Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu 
            100                 105                 110         


Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu 
        115                 120                 125             


Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu 
    130                 135                 140                 


Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val 
145                 150                 155                 160 


Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg 
                165                 170                 175     


Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln 
            180                 185                 190         


Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys 
        195                 200                 205             


Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu 
    210                 215                 220                 


Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala 
225                 230                 235                 240 


Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu 
                245                 250                 255     


Gln Leu Glu Thr Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu 
            260                 265                 270         


Arg Gln Leu Leu Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr 
        275                 280                 285             


Gln Asp Asp Pro Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val 
    290                 295                 300                 


Thr Glu Leu Leu Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr 
305                 310                 315                 320 


Gln Pro Cys Met Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr 
                325                 330                 335     


Gly Ser Lys Phe Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu 
            340                 345                 350         


Gly Asn Glu Ser Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro 
        355                 360                 365             


Gln Leu Gln Gly Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys 
    370                 375                 380                 


Thr Leu Thr Pro Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe 
385                 390                 395                 400 


Gly Tyr Leu Thr Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly 
                405                 410                 415     


Ser Asn Lys Gly Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser 
            420                 425                 430         


Phe Thr Val Lys Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Thr 
        435                 440                 445             


Asp Thr Leu Pro Val Val Ile Ile Ser Asn Met Asn Gln Leu Ser Ile 
    450                 455                 460                 


Ala Trp Ala Ser Val Leu Trp Phe Asn Leu Leu Ser Pro Asn Leu Gln 
465                 470                 475                 480 


Asn Gln Gln Phe Phe Ser Asn Pro Pro Lys Ala Pro Trp Ser Leu Leu 
                485                 490                 495     


Gly Pro Ala Leu Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu 
            500                 505                 510         


Asn Ser Asp Gln Leu Ser Met Leu Arg Asn Lys Leu Phe Gly Gln Asn 
        515                 520                 525             


Cys Arg Thr Glu Asp Pro Leu Leu Ser Trp Ala Asp Phe Thr Lys Arg 
    530                 535                 540                 


Glu Ser Pro Pro Gly Lys Leu Pro Phe Trp Thr Trp Leu Asp Lys Ile 
545                 550                 555                 560 


Leu Glu Leu Val His Asp His Leu Lys Asp Leu Trp Asn Asp Gly Arg 
                565                 570                 575     


Ile Met Gly Phe Val Ser Arg Ser Gln Glu Arg Arg Leu Leu Lys Lys 
            580                 585                 590         


Thr Met Ser Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Glu Gly 
        595                 600                 605             


Gly Ile Thr Cys Ser Trp Val Glu His Gln Asp Asp Asp Lys Val Leu 
    610                 615                 620                 


Ile Tyr Ser Val Gln Pro Tyr Thr Lys Glu Val Leu Gln Ser Leu Pro 
625                 630                 635                 640 


Leu Thr Glu Ile Ile Arg His Tyr Gln Leu Leu Thr Glu Glu Asn Ile 
                645                 650                 655     


Pro Glu Asn Pro Leu Arg Phe Leu Tyr Pro Arg Ile Pro Arg Asp Glu 
            660                 665                 670         


Ala Phe Gly Cys Tyr Tyr Gln Glu Lys Val Asn Leu Gln Glu Arg Arg 
        675                 680                 685             


Lys Tyr Leu Lys His Arg Leu Ile Val Val Ser Asn Arg Gln Val Asp 
    690                 695                 700                 


Glu Leu Gln Gln Pro Leu Glu Leu Lys Pro Glu Pro Glu Leu Glu Ser 
705                 710                 715                 720 


Leu Glu Leu Glu Leu Gly Leu Val Pro Glu Pro Glu Leu Ser Leu Asp 
                725                 730                 735     


Leu Glu Pro Leu Leu Lys Ala Gly Leu Asp Leu Gly Pro Glu Leu Glu 
            740                 745                 750         


Ser Val Leu Glu Ser Thr Leu Glu Pro Val Ile Glu Pro Thr Leu Cys 
        755                 760                 765             


Met Val Ser Gln Thr Val Pro Glu Pro Asp Gln Gly Pro Val Ser Gln 
    770                 775                 780                 


Pro Val Pro Glu Pro Asp Leu Pro Cys Asp Leu Arg His Leu Asn Thr 
785                 790                 795                 800 


Glu Pro Met Glu Ile Phe Arg Asn Cys Val Lys Ile Glu Glu Ile Met 
                805                 810                 815     


Pro Asn Gly Asp Pro Leu Leu Ala Gly Gln Asn Thr Val Asp Glu Val 
            820                 825                 830         


Tyr Val Ser Arg Pro Ser His Phe Tyr Thr Asp Gly Pro Leu Met Pro 
        835                 840                 845             


Ser Asp Phe 
    850     


<210>  4
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210>  5
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ala Ala Pro Tyr 
    690                 695                 700                 


Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn Thr 
705                 710                 715                 720 


Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln Phe 
                725                 730                 735     


Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe Glu 
            740                 745                 750         


Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser Pro 
        755                 760                 765             


Met 
    


<210>  6
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Phe Ile Asp Ala Val 
705                 710                 715                 720 


Trp Lys 
        


<210>  7
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Gln Trp Asn Gln Val Gln Gln Leu Glu Ile Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val Asp Gln Phe Tyr Asp Asp Asn Phe Pro Met Glu Ile Arg His 
            20                  25                  30          


Leu Leu Ala Gln Trp Ile Glu Asn Gln Asp Trp Glu Ala Ala Ser Asn 
        35                  40                  45              


Asn Glu Thr Met Ala Thr Ile Leu Leu Gln Asn Leu Leu Ile Gln Leu 
    50                  55                  60                  


Asp Glu Gln Leu Gly Arg Val Ser Lys Glu Lys Asn Leu Leu Leu Ile 
65                  70                  75                  80  


His Asn Leu Lys Arg Ile Arg Lys Val Leu Gln Gly Lys Phe His Gly 
                85                  90                  95      


Asn Pro Met His Val Ala Val Val Ile Ser Asn Cys Leu Arg Glu Glu 
            100                 105                 110         


Arg Arg Ile Leu Ala Ala Ala Asn Met Pro Val Gln Gly Pro Leu Glu 
        115                 120                 125             


Lys Ser Leu Gln Ser Ser Ser Val Ser Glu Arg Gln Arg Asn Val Glu 
    130                 135                 140                 


His Lys Val Ala Ala Ile Lys Asn Ser Val Gln Met Thr Glu Gln Asp 
145                 150                 155                 160 


Thr Lys Tyr Leu Glu Asp Leu Gln Asp Glu Phe Asp Tyr Arg Tyr Lys 
                165                 170                 175     


Thr Ile Gln Thr Met Asp Gln Ser Asp Lys Asn Ser Ala Met Val Asn 
            180                 185                 190         


Gln Glu Val Leu Thr Leu Gln Glu Met Leu Asn Ser Leu Asp Phe Lys 
        195                 200                 205             


Arg Lys Glu Ala Leu Ser Lys Met Thr Gln Ile Ile His Glu Thr Asp 
    210                 215                 220                 


Leu Leu Met Asn Thr Met Leu Ile Glu Glu Leu Gln Asp Trp Lys Arg 
225                 230                 235                 240 


Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Leu His Asn Gly Leu Asp 
                245                 250                 255     


Gln Leu Gln Asn Cys Phe Thr Leu Leu Ala Glu Ser Leu Phe Gln Leu 
            260                 265                 270         


Arg Arg Gln Leu Glu Lys Leu Glu Glu Gln Ser Thr Lys Met Thr Tyr 
        275                 280                 285             


Glu Gly Asp Pro Ile Pro Met Gln Arg Thr His Met Leu Glu Arg Val 
    290                 295                 300                 


Thr Phe Leu Ile Tyr Asn Leu Phe Lys Asn Ser Phe Val Val Glu Arg 
305                 310                 315                 320 


Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys Thr 
                325                 330                 335     


Leu Ile Gln Phe Thr Val Lys Leu Arg Leu Leu Ile Lys Leu Pro Glu 
            340                 345                 350         


Leu Asn Tyr Gln Val Lys Val Lys Ala Ser Ile Asp Lys Asn Val Ser 
        355                 360                 365             


Thr Leu Ser Asn Arg Arg Phe Val Leu Cys Gly Thr Asn Val Lys Ala 
    370                 375                 380                 


Met Ser Ile Glu Glu Ser Ser Asn Gly Ser Leu Ser Val Glu Phe Arg 
385                 390                 395                 400 


His Leu Gln Pro Lys Glu Met Lys Ser Ser Ala Gly Gly Lys Gly Asn 
                405                 410                 415     


Glu Gly Cys His Met Val Thr Glu Glu Leu His Ser Ile Thr Phe Glu 
            420                 425                 430         


Thr Gln Ile Cys Leu Tyr Gly Leu Thr Ile Asp Leu Glu Thr Ser Ser 
        435                 440                 445             


Leu Pro Val Val Met Ile Ser Asn Val Ser Gln Leu Pro Asn Ala Trp 
    450                 455                 460                 


Ala Ser Ile Ile Trp Tyr Asn Val Ser Thr Asn Asp Ser Gln Asn Leu 
465                 470                 475                 480 


Val Phe Phe Asn Asn Pro Pro Pro Ala Thr Leu Ser Gln Leu Leu Glu 
                485                 490                 495     


Val Met Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu Asn Ser 
            500                 505                 510         


Asp Gln Leu His Met Leu Ala Glu Lys Leu Thr Val Gln Ser Ser Tyr 
        515                 520                 525             


Ser Asp Gly His Leu Thr Trp Ala Lys Phe Cys Lys Glu His Leu Pro 
    530                 535                 540                 


Gly Lys Ser Phe Thr Phe Trp Thr Trp Leu Glu Ala Ile Leu Asp Leu 
545                 550                 555                 560 


Ile Lys Lys His Ile Leu Pro Leu Trp Ile Asp Gly Tyr Val Met Gly 
                565                 570                 575     


Phe Val Ser Lys Glu Lys Glu Arg Leu Leu Leu Lys Asp Lys Met Pro 
            580                 585                 590         


Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser His Leu Gly Gly Ile Thr 
        595                 600                 605             


Phe Thr Trp Val Asp His Ser Glu Ser Gly Glu Val Arg Phe His Ser 
    610                 615                 620                 


Val Glu Pro Tyr Asn Lys Gly Arg Leu Ser Ala Leu Pro Phe Ala Asp 
625                 630                 635                 640 


Ile Leu Arg Asp Tyr Lys Val Ile Met Ala Glu Asn Ile Pro Glu Asn 
                645                 650                 655     


Pro Leu Lys Tyr Leu Tyr Pro Asp Ile Pro Lys Asp Lys Ala Phe Gly 
            660                 665                 670         


Lys His Tyr Ser Ser Gln Pro Cys Glu Val Ser Arg Pro Thr Glu Arg 
        675                 680                 685             


Gly Asp Lys Gly Tyr Val Pro Ser Val Phe Ile Pro Ile Ser Thr Ile 
    690                 695                 700                 


Arg Ser Asp Ser Thr Glu Pro His Ser Pro Ser Asp Leu Leu Pro Met 
705                 710                 715                 720 


Ser Pro Ser Val Tyr Ala Val Leu Arg Glu Asn Leu Ser Pro Thr Thr 
                725                 730                 735     


Ile Glu Thr Ala Met Lys Ser Pro Tyr Ser Ala Glu 
            740                 745             


<210>  8
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gly Trp Ile Gln Ala Gln Gln Leu Gln Gly Asp Ala Leu Arg 
1               5                   10                  15      


Gln Met Gln Val Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          


Tyr Leu Ala Gln Trp Ile Glu Ser Gln Pro Trp Asp Ala Ile Asp Leu 
        35                  40                  45              


Asp Asn Pro Gln Asp Arg Ala Gln Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  


Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  


Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Lys 
                85                  90                  95      


Thr Tyr Asp Arg Cys Pro Leu Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         


Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Cys Ser Ser 
        115                 120                 125             


Pro Ala Gly Ile Leu Val Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 


Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 


Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     


Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Ala Gln Leu Ala Gln Leu 
            180                 185                 190         


Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             


Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 


Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 


Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     


Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         


Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             


Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 


Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 


Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     


Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         


Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             


Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 


Asn Glu Asn Thr Arg Asn Glu Cys Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 


Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     


Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ala Asp Arg Arg Gly Ala 
            420                 425                 430         


Glu Ser Val Thr Glu Glu Lys Phe Thr Val Leu Phe Glu Ser Gln Phe 
        435                 440                 445             


Ser Val Gly Ser Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 


Pro Val Val Val Ile Val His Gly Ser Gln Asp His Asn Ala Thr Ala 
465                 470                 475                 480 


Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     


Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         


Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             


Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His 
    530                 535                 540                 


Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 


Glu Asn Leu Pro Gly Trp Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     


Val Met Glu Val Leu Lys Lys His His Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         


Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             


Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 


Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Pro Glu Arg Asn Leu 
625                 630                 635                 640 


Trp Asn Leu Lys Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     


Ala Asp Arg Leu Gly Asp Leu Ser Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         


Arg Pro Lys Asp Glu Val Phe Ser Lys Tyr Tyr Thr Pro Val Leu Ala 
        675                 680                 685             


Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile Lys Gln Val Val Pro 
    690                 695                 700                 


Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly Ser Ser Ala Thr Tyr 
705                 710                 715                 720 


Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro Gln Ala Pro Tyr Asn 
                725                 730                 735     


Met Tyr Pro Gln Asn Pro Asp His Val Leu Asp Gln Asp Gly Glu Phe 
            740                 745                 750         


Asp Leu Asp Glu Thr Met Asp Val Ala Arg His Val Glu Glu Leu Leu 
        755                 760                 765             


Arg Arg Pro Met Asp Ser Leu Asp Ser Arg Leu Ser Pro Pro Ala Gly 
    770                 775                 780                 


Leu Phe Thr Ser Ala Arg Gly Ser Leu Ser 
785                 790                 


<210>  9
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Val Trp Ile Gln Ala Gln Gln Leu Gln Gly Glu Ala Leu His 
1               5                   10                  15      


Gln Met Gln Ala Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          


Tyr Leu Ser Gln Trp Ile Glu Ser Gln Ala Trp Asp Ser Val Asp Leu 
        35                  40                  45              


Asp Asn Pro Gln Glu Asn Ile Lys Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  


Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  


Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Asn 
                85                  90                  95      


Thr Tyr Asp Arg Cys Pro Met Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         


Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Gly Ser Ser 
        115                 120                 125             


Pro Ala Gly Ser Leu Ala Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 


Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 


Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     


Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Gly Pro Leu Ala Gln Leu 
            180                 185                 190         


Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             


Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 


Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 


Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     


Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         


Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             


Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 


Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 


Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     


Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         


Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             


Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 


Asn Glu Asn Thr Arg Asn Asp Tyr Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 


Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     


Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ser Asp Arg Arg Gly Ala 
            420                 425                 430         


Glu Ser Val Thr Glu Glu Lys Phe Thr Ile Leu Phe Glu Ser Gln Phe 
        435                 440                 445             


Ser Val Gly Gly Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 


Pro Val Val Val Ile Val His Gly Ser Gln Asp Asn Asn Ala Thr Ala 
465                 470                 475                 480 


Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     


Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         


Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             


Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His 
    530                 535                 540                 


Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 


Glu Asn Leu Pro Gly Arg Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     


Val Met Glu Val Leu Lys Lys His Leu Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         


Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             


Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 


Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Gln Glu Arg Met Phe 
625                 630                 635                 640 


Trp Asn Leu Met Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     


Ala Asp Arg Leu Gly Asp Leu Asn Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         


Arg Pro Lys Asp Glu Val Tyr Ser Lys Tyr Tyr Thr Pro Val Pro Cys 
        675                 680                 685             


Glu Ser Ala Thr Ala Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile 
    690                 695                 700                 


Lys Gln Val Val Pro Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly 
705                 710                 715                 720 


Gly Ser Ala Thr Tyr Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro 
                725                 730                 735     


Gln Ala His Tyr Asn Met Tyr Pro Gln Asn Pro Asp Ser Val Leu Asp 
            740                 745                 750         


Thr Asp Gly Asp Phe Asp Leu Glu Asp Thr Met Asp Val Ala Arg Arg 
        755                 760                 765             


Val Glu Glu Leu Leu Gly Arg Pro Met Asp Ser Gln Trp Ile Pro His 
    770                 775                 780                 


Ala Gln Ser 
785         


<210>  10
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln 
1               5                   10                  15      


Arg Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp 
            20                  25                  30          


Trp Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe 
        35                  40                  45              


Cys Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu 
    50                  55                  60                  


Gln Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His 
65                  70                  75                  80  


Ile Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val 
                85                  90                  95      


Ala Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu 
            100                 105                 110         


Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu 
        115                 120                 125             


Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile 
    130                 135                 140                 


His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val 
145                 150                 155                 160 


Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser 
                165                 170                 175     


Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala 
            180                 185                 190         


Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln 
        195                 200                 205             


Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln 
225                 230                 235                 240 


Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser 
                245                 250                 255     


Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys 
            260                 265                 270         


Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys 
        275                 280                 285             


Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala 
    290                 295                 300                 


Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln 
305                 310                 315                 320 


Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser 
                325                 330                 335     


Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro 
            340                 345                 350         


Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile 
        355                 360                 365             


Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys 
    370                 375                 380                 


Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro 
385                 390                 395                 400 


Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly 
                405                 410                 415     


Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe 
            420                 425                 430         


Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp 
        435                 440                 445             


Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly 
    450                 455                 460                 


Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys 
465                 470                 475                 480 


Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser 
                485                 490                 495     


Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe 
            500                 505                 510         


Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys 
        515                 520                 525             


Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys 
    530                 535                 540                 


Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu 
545                 550                 555                 560 


Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val 
                565                 570                 575     


Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe 
            580                 585                 590         


Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp 
        595                 600                 605             


Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala 
    610                 615                 620                 


Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly 
625                 630                 635                 640 


Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu 
                645                 650                 655     


Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu 
            660                 665                 670         


Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met 
        675                 680                 685             


Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu 
705                 710                 715                 720 


Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe 
                725                 730                 735     


Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His 
            740                 745                 750         


Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val 
        755                 760                 765             


Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr 
    770                 775                 780                 


Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln 
785                 790                 795                 800 


Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly 
                805                 810                 815     


Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser 
            820                 825                 830         


Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp 
        835                 840                 845         


<210>  11
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val Ala His Asn Gln Val Ala Ala Asp Asn Ala Val Ser Thr Ala 
1               5                   10                  15      


Ala Glu Pro Arg Arg Arg Pro Glu Pro Ser Ser Ser Ser Ser Ser Ser 
            20                  25                  30          


Pro Ala Ala Pro Ala Arg Pro Arg Pro Cys Pro Ala Val Pro Ala Pro 
        35                  40                  45              


Ala Pro Gly Asp Thr His Phe Arg Thr Phe Arg Ser His Ala Asp Tyr 
    50                  55                  60                  


Arg Arg Ile Thr Arg Ala Ser Ala Leu Leu Asp Ala Cys Gly Phe Tyr 
65                  70                  75                  80  


Trp Gly Pro Leu Ser Val His Gly Ala His Glu Arg Leu Arg Ala Glu 
                85                  90                  95      


Pro Val Gly Thr Phe Leu Val Arg Asp Ser Arg Gln Arg Asn Cys Phe 
            100                 105                 110         


Phe Ala Leu Ser Val Lys Met Ala Ser Gly Pro Thr Ser Ile Arg Val 
        115                 120                 125             


His Phe Gln Ala Gly Arg Phe His Leu Asp Gly Ser Arg Glu Ser Phe 
    130                 135                 140                 


Asp Cys Leu Phe Glu Leu Leu Glu His Tyr Val Ala Ala Pro Arg Arg 
145                 150                 155                 160 


Met Leu Gly Ala Pro Leu Arg Gln Arg Arg Val Arg Pro Leu Gln Glu 
                165                 170                 175     


Leu Cys Arg Gln Arg Ile Val Ala Thr Val Gly Arg Glu Asn Leu Ala 
            180                 185                 190         


Arg Ile Pro Leu Asn Pro Val Leu Arg Asp Tyr Leu Ser Ser Phe Pro 
        195                 200                 205             


Phe Gln Ile 
    210     


<210>  12
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210>  13
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Thr His Ser Lys Phe Pro Ala Ala Gly Met Ser Arg Pro Leu 
1               5                   10                  15      


Asp Thr Ser Leu Arg Leu Lys Thr Phe Ser Ser Lys Ser Glu Tyr Gln 
            20                  25                  30          


Leu Val Val Asn Ala Val Arg Lys Leu Gln Glu Ser Gly Phe Tyr Trp 
        35                  40                  45              


Ser Ala Val Thr Gly Gly Glu Ala Asn Leu Leu Leu Ser Ala Glu Pro 
    50                  55                  60                  


Ala Gly Thr Phe Leu Ile Arg Asp Ser Ser Asp Gln Arg His Phe Phe 
65                  70                  75                  80  


Thr Leu Ser Val Lys Thr Gln Ser Gly Thr Lys Asn Leu Arg Ile Gln 
                85                  90                  95      


Cys Glu Gly Gly Ser Phe Ser Leu Gln Ser Asp Pro Arg Ser Thr Gln 
            100                 105                 110         


Pro Val Pro Arg Phe Asp Cys Val Leu Lys Leu Val His His Tyr Met 
        115                 120                 125             


Pro Pro Pro Gly Ala Pro Ser Phe Pro Ser Pro Pro Thr Glu Pro Ser 
    130                 135                 140                 


Ser Glu Val Pro Glu Gln Pro Ser Ala Gln Pro Leu Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Arg Arg Ala Tyr Tyr Ile Tyr Ser Gly Gly Glu Lys Ile Pro Leu 
                165                 170                 175     


Val Leu Ser Arg Pro Leu Ser Ser Asn Val Ala Thr Leu Gln His Leu 
            180                 185                 190         


Cys Arg Lys Thr Val Asn Gly His Leu Asp Ser Tyr Glu Lys Val Thr 
        195                 200                 205             


Gln Leu Pro Gly Pro Ile Arg Glu Phe Leu Asp Gln Tyr Asp Ala Pro 
    210                 215                 220                 


Leu 
225 


<210>  14
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Glu Asn Asn Glu Asn Ile Ser Lys Asn Val Asp Val Arg Pro 
1               5                   10                  15      


Lys Thr Ser Arg Ser Arg Ser Ala Asp Arg Lys Asp Gly Tyr Val Trp 
            20                  25                  30          


Ser Gly Lys Lys Leu Ser Trp Ser Lys Lys Ser Glu Ser Tyr Ser Asp 
        35                  40                  45              


Ala Glu Thr Val Asn Gly Ile Glu Lys Thr Glu Val Ser Leu Arg Asn 
    50                  55                  60                  


Gln Glu Arg Lys His Ser Cys Ser Ser Ile Glu Leu Asp Leu Asp His 
65                  70                  75                  80  


Ser Cys Gly His Arg Phe Leu Gly Arg Ser Leu Lys Gln Lys Leu Gln 
                85                  90                  95      


Asp Ala Val Gly Gln Cys Phe Pro Ile Lys Asn Cys Ser Ser Arg His 
            100                 105                 110         


Ser Ser Gly Leu Pro Ser Lys Arg Lys Ile His Ile Ser Glu Leu Met 
        115                 120                 125             


Leu Asp Lys Cys Pro Phe Pro Pro Arg Ser Asp Leu Ala Phe Arg Trp 
    130                 135                 140                 


His Phe Ile Lys Arg His Thr Ala Pro Ile Asn Ser Lys Ser Asp Glu 
145                 150                 155                 160 


Trp Val Ser Thr Asp Leu Ser Gln Thr Glu Leu Arg Asp Gly Gln Leu 
                165                 170                 175     


Lys Arg Arg Asn Met Glu Glu Asn Ile Asn Cys Phe Ser His Thr Asn 
            180                 185                 190         


Val Gln Pro Cys Val Ile Thr Thr Asp Asn Ala Leu Cys Arg Glu Gly 
        195                 200                 205             


Pro Met Thr Gly Ser Val Met Asn Leu Val Ser Asn Asn Ser Ile Glu 
    210                 215                 220                 


Asp Ser Asp Met Asp Ser Asp Asp Glu Ile Leu Thr Leu Cys Thr Ser 
225                 230                 235                 240 


Ser Arg Lys Arg Asn Lys Pro Lys Trp Asp Leu Asp Asp Glu Ile Leu 
                245                 250                 255     


Gln Leu Glu Thr Pro Pro Lys Tyr His Thr Gln Ile Asp Tyr Val His 
            260                 265                 270         


Cys Leu Val Pro Asp Leu Leu Gln Ile Asn Asn Asn Pro Cys Tyr Trp 
        275                 280                 285             


Gly Val Met Asp Lys Tyr Ala Ala Glu Ala Leu Leu Glu Gly Lys Pro 
    290                 295                 300                 


Glu Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe 
305                 310                 315                 320 


Ser Val Ser Phe Arg Arg Tyr Ser Arg Ser Leu His Ala Arg Ile Glu 
                325                 330                 335     


Gln Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe 
            340                 345                 350         


His Ser Pro Asp Ile Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser 
        355                 360                 365             


Ala Cys Met Phe Phe Glu Pro Leu Leu Ser Thr Pro Leu Ile Arg Thr 
    370                 375                 380                 


Phe Pro Phe Ser Leu Gln His Ile Cys Arg Thr Val Ile Cys Asn Cys 
385                 390                 395                 400 


Thr Thr Tyr Asp Gly Ile Asp Ala Leu Pro Ile Pro Ser Ser Met Lys 
                405                 410                 415     


Leu Tyr Leu Lys Glu Tyr His Tyr Lys Ser Lys Val Arg Val Leu Arg 
            420                 425                 430         


Ile Asp Ala Pro Glu Gln Gln Cys 
        435                 440 


<210>  15
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Glu Asn Asn Glu Asn Ile Ser Lys Asn Val Asp Val Arg Pro 
1               5                   10                  15      


Lys Thr Ser Arg Ser Arg Ser Ala Asp Arg Lys Asp Gly Tyr Val Trp 
            20                  25                  30          


Ser Gly Lys Lys Leu Ser Trp Ser Lys Lys Ser Glu Ser Tyr Ser Asp 
        35                  40                  45              


Ala Glu Thr Val Asn Gly Ile Glu Lys Thr Glu Val Ser Leu Arg Asn 
    50                  55                  60                  


Gln Glu Arg Lys His Ser Cys Ser Ser Ile Glu Leu Asp Leu Asp His 
65                  70                  75                  80  


Ser Cys Gly His Arg Phe Leu Gly Arg Ser Leu Lys Gln Lys Leu Gln 
                85                  90                  95      


Asp Ala Val Gly Gln Cys Phe Pro Ile Lys Asn Cys Ser Ser Arg His 
            100                 105                 110         


Ser Ser Gly Leu Pro Ser Lys Arg Lys Ile His Ile Ser Glu Leu Met 
        115                 120                 125             


Leu Asp Lys Cys Pro Phe Pro Pro Arg Ser Asp Leu Ala Phe Arg Trp 
    130                 135                 140                 


His Phe Ile Lys Arg His Thr Ala Pro Ile Asn Ser Lys Ser Asp Glu 
145                 150                 155                 160 


Trp Val Ser Thr Asp Leu Ser Gln Thr Glu Leu Arg Asp Gly Gln Leu 
                165                 170                 175     


Lys Arg Arg Asn Met Glu Glu Asn Ile Asn Cys Phe Ser His Thr Asn 
            180                 185                 190         


Val Gln Pro Cys Val Ile Thr Thr Asp Asn Ala Leu Cys Arg Glu Gly 
        195                 200                 205             


Pro Met Thr Gly Ser Val Met Asn Leu Val Ser Asn Asn Ser Ile Glu 
    210                 215                 220                 


Asp Ser Asp Met Asp Ser Asp Asp Glu Ile Leu Thr Leu Cys Thr Ser 
225                 230                 235                 240 


Ser Arg Lys Arg Asn Lys Pro Lys Trp Asp Leu Asp Asp Glu Ile Leu 
                245                 250                 255     


Gln Leu Glu Thr Pro Pro Lys Tyr His Thr Gln Ile Asp Tyr Val His 
            260                 265                 270         


Cys Leu Val Pro Asp Leu Leu Gln Ile Asn Asn Asn Pro Cys Tyr Trp 
        275                 280                 285             


Gly Val Met Asp Lys Tyr Ala Ala Glu Ala Leu Leu Glu Gly Lys Pro 
    290                 295                 300                 


Glu Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe 
305                 310                 315                 320 


Ser Val Ser Phe Arg Arg Tyr Ser Arg Ser Leu His Ala Arg Ile Glu 
                325                 330                 335     


Gln Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe 
            340                 345                 350         


His Ser Pro Asp Ile Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser 
        355                 360                 365             


Ala Cys Met Phe Phe Glu Pro Leu Leu Ser Thr Pro Leu Ile Arg Thr 
    370                 375                 380                 


Phe Pro Phe Ser Leu Gln His Ile Cys Arg Thr Val Ile Cys Asn Cys 
385                 390                 395                 400 


Thr Thr Tyr Asp Gly Ile Asp Ala Leu Pro Ile Pro Ser Ser Met Lys 
                405                 410                 415     


Leu Tyr Leu Lys Glu Tyr His Tyr Lys Ser Lys Val Arg Val Leu Arg 
            420                 425                 430         


Ile Asp Ala Pro Glu Gln Gln Cys 
        435                 440 


<210>  16
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     


<210>  17
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     


<210>  18
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Lys Ile Ser Leu Lys Thr Leu Arg Lys Ser Phe Asn Leu Asn 
1               5                   10                  15      


Lys Ser Lys Glu Glu Thr Asp Phe Met Val Val Gln Gln Pro Ser Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Lys Asp Asp Ser Leu Phe Gly Ser Cys Tyr Gly 
        35                  40                  45              


Lys Asp Met Ala Ser Cys Asp Ile Asn Gly Glu Asp Glu Lys Gly Gly 
    50                  55                  60                  


Lys Asn Arg Ser Lys Ser Glu Ser Leu Met Gly Thr Leu Lys Arg Arg 
65                  70                  75                  80  


Leu Ser Ala Lys Gln Lys Ser Lys Gly Lys Ala Gly Thr Pro Ser Gly 
                85                  90                  95      


Ser Ser Ala Asp Glu Asp Thr Phe Ser Ser Ser Ser Ala Pro Ile Val 
            100                 105                 110         


Phe Lys Asp Val Arg Ala Gln Arg Pro Ile Arg Ser Thr Ser Leu Arg 
        115                 120                 125             


Ser His His Tyr Ser Pro Ala Pro Trp Pro Leu Arg Pro Thr Asn Ser 
    130                 135                 140                 


Glu Glu Thr Cys Ile Lys Met Glu Val Arg Val Lys Ala Leu Val His 
145                 150                 155                 160 


Ser Ser Ser Pro Ser Pro Ala Leu Asn Gly Val Arg Lys Asp Phe His 
                165                 170                 175     


Asp Leu Gln Ser Glu Thr Thr Cys Gln Glu Gln Ala Asn Ser Leu Lys 
            180                 185                 190         


Ser Ser Ala Ser His Asn Gly Asp Leu His Leu His Leu Asp Glu His 
        195                 200                 205             


Val Pro Val Val Ile Gly Leu Met Pro Gln Asp Tyr Ile Gln Tyr Thr 
    210                 215                 220                 


Val Pro Leu Asp Glu Gly Met Tyr Pro Leu Glu Gly Ser Arg Ser Tyr 
225                 230                 235                 240 


Cys Leu Asp Ser Ser Ser Pro Met Glu Val Ser Ala Val Pro Pro Gln 
                245                 250                 255     


Val Gly Gly Arg Ala Phe Pro Glu Asp Glu Ser Gln Val Asp Gln Asp 
            260                 265                 270         


Leu Val Val Ala Pro Glu Ile Phe Val Asp Gln Ser Val Asn Gly Leu 
        275                 280                 285             


Leu Ile Gly Thr Thr Gly Val Met Leu Gln Ser Pro Arg Ala Gly His 
    290                 295                 300                 


Asp Asp Val Pro Pro Leu Ser Pro Leu Leu Pro Pro Met Gln Asn Asn 
305                 310                 315                 320 


Gln Ile Gln Arg Asn Phe Ser Gly Leu Thr Gly Thr Glu Ala His Val 
                325                 330                 335     


Ala Glu Ser Met Arg Cys His Leu Asn Phe Asp Pro Asn Ser Ala Pro 
            340                 345                 350         


Gly Val Ala Arg Val Tyr Asp Ser Val Gln Ser Ser Gly Pro Met Val 
        355                 360                 365             


Val Thr Ser Leu Thr Glu Glu Leu Lys Lys Leu Ala Lys Gln Gly Trp 
    370                 375                 380                 


Tyr Trp Gly Pro Ile Thr Arg Trp Glu Ala Glu Gly Lys Leu Ala Asn 
385                 390                 395                 400 


Val Pro Asp Gly Ser Phe Leu Val Arg Asp Ser Ser Asp Asp Arg Tyr 
                405                 410                 415     


Leu Leu Ser Leu Ser Phe Arg Ser His Gly Lys Thr Leu His Thr Arg 
            420                 425                 430         


Ile Glu His Ser Asn Gly Arg Phe Ser Phe Tyr Glu Gln Pro Asp Val 
        435                 440                 445             


Glu Gly His Thr Ser Ile Val Asp Leu Ile Glu His Ser Ile Arg Asp 
    450                 455                 460                 


Ser Glu Asn Gly Ala Phe Cys Tyr Ser Arg Ser Arg Leu Pro Gly Ser 
465                 470                 475                 480 


Ala Thr Tyr Pro Val Arg Leu Thr Asn Pro Val Ser Arg Phe Met Gln 
                485                 490                 495     


Val Arg Ser Leu Gln Tyr Leu Cys Arg Phe Val Ile Arg Gln Tyr Thr 
            500                 505                 510         


Arg Ile Asp Leu Ile Gln Lys Leu Pro Leu Pro Asn Lys Met Lys Asp 
        515                 520                 525             


Tyr Leu Gln Glu Lys His Tyr 
    530                 535 


<210>  19
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Val Phe Arg Asn Val Gly Arg Pro Pro Glu Glu Glu Asp Val Glu 
1               5                   10                  15      


Ala Ala Pro Glu Pro Gly Pro Ser Glu Leu Leu Cys Pro Arg His Arg 
            20                  25                  30          


Cys Ala Leu Asp Pro Lys Ala Leu Pro Pro Gly Leu Ala Leu Glu Arg 
        35                  40                  45              


Thr Trp Gly Pro Ala Ala Gly Leu Glu Ala Gln Leu Ala Ala Leu Gly 
    50                  55                  60                  


Leu Gly Gln Pro Ala Gly Pro Gly Val Lys Thr Val Gly Gly Gly Cys 
65                  70                  75                  80  


Cys Pro Cys Pro Cys Pro Pro Gln Pro Pro Pro Pro Gln Pro Gln Pro 
                85                  90                  95      


Pro Ala Ala Ala Pro Gln Ala Gly Glu Asp Pro Thr Glu Thr Ser Asp 
            100                 105                 110         


Ala Leu Leu Val Leu Glu Gly Leu Glu Ser Glu Ala Glu Ser Leu Glu 
        115                 120                 125             


Thr Asn Ser Cys Ser Glu Glu Glu Leu Ser Ser Pro Gly Arg Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Arg Leu Leu Leu Gln Pro Pro Gly Pro Glu Leu Pro 
145                 150                 155                 160 


Pro Val Pro Phe Pro Leu Gln Asp Leu Val Pro Leu Gly Arg Leu Ser 
                165                 170                 175     


Arg Gly Glu Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro 
            180                 185                 190         


Pro Pro Pro Gly Pro Leu Arg Pro Leu Ala Gly Pro Ser Arg Lys Gly 
        195                 200                 205             


Ser Phe Lys Ile Arg Leu Ser Arg Leu Phe Arg Thr Lys Ser Cys Asn 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Asp Gly Thr Gly Lys Arg Pro Ser Gly Glu 
225                 230                 235                 240 


Leu Ala Ala Ser Ala Ala Ser Leu Thr Asp Met Gly Gly Ser Ala Gly 
                245                 250                 255     


Arg Glu Leu Asp Ala Gly Arg Lys Pro Lys Leu Thr Arg Thr Gln Ser 
            260                 265                 270         


Ala Phe Ser Pro Val Ser Phe Ser Pro Leu Phe Thr Gly Glu Thr Val 
        275                 280                 285             


Ser Leu Val Asp Val Asp Ile Ser Gln Arg Gly Leu Thr Ser Pro His 
    290                 295                 300                 


Pro Pro Thr Pro Pro Pro Pro Pro Arg Arg Ser Leu Ser Leu Leu Asp 
305                 310                 315                 320 


Asp Ile Ser Gly Thr Leu Pro Thr Ser Val Leu Val Ala Pro Met Gly 
                325                 330                 335     


Ser Ser Leu Gln Ser Phe Pro Leu Pro Pro Pro Pro Pro Pro His Ala 
            340                 345                 350         


Pro Asp Ala Phe Pro Arg Ile Ala Pro Ile Arg Ala Ala Glu Ser Leu 
        355                 360                 365             


His Ser Gln Pro Pro Gln His Leu Gln Cys Pro Leu Tyr Arg Pro Asp 
    370                 375                 380                 


Ser Ser Ser Phe Ala Ala Ser Leu Arg Glu Leu Glu Lys Cys Gly Trp 
385                 390                 395                 400 


Tyr Trp Gly Pro Met Asn Trp Glu Asp Ala Glu Met Lys Leu Lys Gly 
                405                 410                 415     


Lys Pro Asp Gly Ser Phe Leu Val Arg Asp Ser Ser Asp Pro Arg Tyr 
            420                 425                 430         


Ile Leu Ser Leu Ser Phe Arg Ser Gln Gly Ile Thr His His Thr Arg 
        435                 440                 445             


Met Glu His Tyr Arg Gly Thr Phe Ser Leu Trp Cys His Pro Lys Phe 
    450                 455                 460                 


Glu Asp Arg Cys Gln Ser Val Val Glu Phe Ile Lys Arg Ala Ile Met 
465                 470                 475                 480 


His Ser Lys Asn Gly Lys Phe Leu Tyr Phe Leu Arg Ser Arg Val Pro 
                485                 490                 495     


Gly Leu Pro Pro Thr Pro Val Gln Leu Leu Tyr Pro Val Ser Arg Phe 
            500                 505                 510         


Ser Asn Val Lys Ser Leu Gln His Leu Cys Arg Phe Arg Ile Arg Gln 
        515                 520                 525             


Leu Val Arg Ile Asp His Ile Pro Asp Leu Pro Leu Pro Lys Pro Leu 
    530                 535                 540                 


Ile Ser Tyr Ile Arg Lys Phe Tyr Tyr Tyr Asp Pro Gln Glu Glu Val 
545                 550                 555                 560 


Tyr Leu Ser Leu Lys Glu Ala Gln Leu Ile Ser Lys Gln Lys Gln Glu 
                565                 570                 575     


Val Glu Pro Ser Thr 
            580     


<210>  20
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Tyr Leu Glu His Thr Ser His Cys Pro His His Asp Asp Asp Thr 
1               5                   10                  15      


Ala Met Asp Thr Pro Leu Pro Arg Pro Arg Pro Leu Leu Ala Val Glu 
            20                  25                  30          


Arg Thr Gly Gln Arg Pro Leu Trp Ala Pro Ser Leu Glu Leu Pro Lys 
        35                  40                  45              


Pro Val Met Gln Pro Leu Pro Ala Gly Ala Phe Leu Glu Glu Val Ala 
    50                  55                  60                  


Glu Gly Thr Pro Ala Gln Thr Glu Ser Glu Pro Lys Val Leu Asp Pro 
65                  70                  75                  80  


Glu Glu Asp Leu Leu Cys Ile Ala Lys Thr Phe Ser Tyr Leu Arg Glu 
                85                  90                  95      


Ser Gly Trp Tyr Trp Gly Ser Ile Thr Ala Ser Glu Ala Arg Gln His 
            100                 105                 110         


Leu Gln Lys Met Pro Glu Gly Thr Phe Leu Val Arg Asp Ser Thr His 
        115                 120                 125             


Pro Ser Tyr Leu Phe Thr Leu Ser Val Lys Thr Thr Arg Gly Pro Thr 
    130                 135                 140                 


Asn Val Arg Ile Glu Tyr Ala Asp Ser Ser Phe Arg Leu Asp Ser Asn 
145                 150                 155                 160 


Cys Leu Ser Arg Pro Arg Ile Leu Ala Phe Pro Asp Val Val Ser Leu 
                165                 170                 175     


Val Gln His Tyr Val Ala Ser Cys Thr Ala Asp Thr Arg Ser Asp Ser 
            180                 185                 190         


Pro Asp Pro Ala Pro Thr Pro Ala Leu Pro Met Pro Lys Glu Asp Ala 
        195                 200                 205             


Pro Ser Asp Pro Ala Leu Pro Ala Pro Pro Pro Ala Thr Ala Val His 
    210                 215                 220                 


Leu Lys Leu Val Gln Pro Phe Val Arg Arg Ser Ser Ala Arg Ser Leu 
225                 230                 235                 240 


Gln His Leu Cys Arg Leu Val Ile Asn Arg Leu Val Ala Asp Val Asp 
                245                 250                 255     


Cys Leu Pro Leu Pro Arg Arg Met Ala Asp Tyr Leu Arg Gln Tyr Pro 
            260                 265                 270         


Phe Gln Leu 
        275 


<210>  21
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Val Leu Cys Val Gln Gly Pro Arg Pro Leu Leu Ala Val Glu Arg 
1               5                   10                  15      


Thr Gly Gln Arg Pro Leu Trp Ala Pro Ser Leu Glu Leu Pro Lys Pro 
            20                  25                  30          


Val Met Gln Pro Leu Pro Ala Gly Ala Phe Leu Glu Glu Val Ala Glu 
        35                  40                  45              


Gly Thr Pro Ala Gln Thr Glu Ser Glu Pro Lys Val Leu Asp Pro Glu 
    50                  55                  60                  


Glu Asp Leu Leu Cys Ile Ala Lys Thr Phe Ser Tyr Leu Arg Glu Ser 
65                  70                  75                  80  


Gly Trp Tyr Trp Gly Ser Ile Thr Ala Ser Glu Ala Arg Gln His Leu 
                85                  90                  95      


Gln Lys Met Pro Glu Gly Thr Phe Leu Val Arg Asp Ser Thr His Pro 
            100                 105                 110         


Ser Tyr Leu Phe Thr Leu Ser Val Lys Thr Thr Arg Gly Pro Thr Asn 
        115                 120                 125             


Val Arg Ile Glu Tyr Ala Asp Ser Ser Phe Arg Leu Asp Ser Asn Cys 
    130                 135                 140                 


Leu Ser Arg Pro Arg Ile Leu Ala Phe Pro Asp Val Val Ser Leu Val 
145                 150                 155                 160 


Gln His Tyr Val Ala Ser Cys Thr Ala Asp Thr Arg Ser Asp Ser Pro 
                165                 170                 175     


Asp Pro Ala Pro Thr Pro Ala Leu Pro Met Pro Lys Glu Asp Ala Pro 
            180                 185                 190         


Ser Asp Pro Ala Leu Pro Ala Pro Pro Pro Ala Thr Ala Val His Leu 
        195                 200                 205             


Lys Leu Val Gln Pro Phe Val Arg Arg Ser Ser Ala Arg Ser Leu Gln 
    210                 215                 220                 


His Leu Cys Arg Leu Val Ile Asn Arg Leu Val Ala Asp Val Asp Cys 
225                 230                 235                 240 


Leu Pro Leu Pro Arg Arg Met Ala Asp Tyr Leu Arg Gln Tyr Pro Phe 
                245                 250                 255     


Gln Leu 
        


<210>  22
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Asp Ser Ala Glu Leu Lys Gln Met Val Met Ser Leu Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys His Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys Ala Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro Asn Val 
65                  70                  75                  80  


His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile Pro Gln 
                85                  90                  95      


Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro Val Ser 
            100                 105                 110         


Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr Ser Ala 
        115                 120                 125             


Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro Phe Tyr 
    130                 135                 140                 


Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser Asp Asn 
145                 150                 155                 160 


Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr Pro Gln 
                165                 170                 175     


Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr Lys Cys 
            180                 185                 190         


Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu Thr Ser 
        195                 200                 205             


Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys Val Asn 
    210                 215                 220                 


Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly 
225                 230                 235                 240 


Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser Leu Val 
                245                 250                 255     


Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp Thr Ala 
            260                 265                 270         


Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys Gln Leu 
        275                 280                 285             


Ser Ser Thr Val Leu Leu Gln Arg Leu Arg Ala Lys Gly Ile Arg Asn 
    290                 295                 300                 


Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro 
305                 310                 315                 320 


Asp Ser Glu Ile Ala Thr Thr Ser Leu Arg Val Ser Leu Leu Cys Pro 
                325                 330                 335     


Leu Gly Lys Met Arg Leu Thr Ile Pro Cys Arg Ala Leu Thr Cys Ser 
            340                 345                 350         


His Leu Gln Cys Phe Asp Ala Thr Leu Tyr Ile Gln Met Asn Glu Lys 
        355                 360                 365             


Lys Pro Thr Trp Val Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu 
    370                 375                 380                 


His Leu Ile Ile Asp Gly Leu Phe Met Glu Ile Leu Lys Tyr Cys Thr 
385                 390                 395                 400 


Asp Cys Asp Glu Ile Gln Phe Lys Glu Asp Gly Thr Trp Ala Pro Met 
                405                 410                 415     


Arg Ser Lys Lys Glu Val Gln Glu Val Ser Ala Ser Tyr Asn Gly Val 
            420                 425                 430         


Asp Gly Cys Leu Ser Ser Thr Leu Glu His Gln Val Ala Ser His His 
        435                 440                 445             


Gln Ser Ser Asn Lys Asn Lys Lys Val Glu Val Ile Asp Leu Thr Ile 
    450                 455                 460                 


Asp Ser Ser Ser Asp Glu Glu Glu Glu Glu Pro Ser Ala Lys Arg Thr 
465                 470                 475                 480 


Cys Pro Ser Leu Ser Pro Thr Ser Pro Leu Asn Asn Lys Gly Ile Leu 
                485                 490                 495     


Ser Leu Pro His Gln Ala Ser Pro Val Ser Arg Thr Pro Ser Leu Pro 
            500                 505                 510         


Ala Val Asp Thr Ser Tyr Ile Asn Thr Ser Leu Ile Gln Asp Tyr Arg 
        515                 520                 525             


His Pro Phe His Met Thr Pro Met Pro Tyr Asp Leu Gln Gly Leu Asp 
    530                 535                 540                 


Phe Phe Pro Phe Leu Ser Gly Asp Asn Gln His Tyr Asn Thr Ser Leu 
545                 550                 555                 560 


Leu Ala Ala Ala Ala Ala Ala Val Ser Asp Asp Gln Asp Leu Leu His 
                565                 570                 575     


Ser Ser Arg Phe Phe Pro Tyr Thr Ser Ser Gln Met Phe Leu Asp Gln 
            580                 585                 590         


Leu Ser Ala Gly Gly Ser Thr Ser Leu Pro Thr Thr Asn Gly Ser Ser 
        595                 600                 605             


Ser Gly Ser Asn Ser Ser Leu Val Ser Ser Asn Ser Leu Arg Glu Ser 
    610                 615                 620                 


His Ser His Thr Val Thr Asn Arg Ser Ser Thr Asp Thr Ala Ser Ile 
625                 630                 635                 640 


Phe Gly Ile Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650     


<210>  23
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Asp Phe Glu Glu Leu Arg Asn Met Val Ser Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Asp Leu Leu Met Arg Ala Leu His Leu Leu Lys Ser Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Ile Lys Ile Arg Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Tyr Pro Arg Thr Leu Glu Gly Leu Ser Asp Leu Ser Thr Ile Lys Ser 
65                  70                  75                  80  


Ser Val Phe Ser Leu Asp Gly Gly Ser Ser Pro Val Glu Pro Asp Leu 
                85                  90                  95      


Ala Val Ala Gly Ile His Ser Leu Pro Ser Thr Ser Val Thr Pro His 
            100                 105                 110         


Ser Pro Ser Ser Pro Val Gly Ser Val Leu Leu Gln Asp Thr Lys Pro 
        115                 120                 125             


Thr Phe Glu Met Gln Gln Pro Ser Pro Pro Ile Pro Pro Val His Pro 
    130                 135                 140                 


Asp Val Gln Leu Lys Asn Leu Pro Phe Tyr Asp Val Leu Asp Val Leu 
145                 150                 155                 160 


Ile Lys Pro Thr Ser Leu Val Gln Ser Ser Ile Gln Arg Phe Gln Glu 
                165                 170                 175     


Lys Phe Phe Ile Phe Ala Leu Thr Pro Gln Gln Val Arg Glu Ile Cys 
            180                 185                 190         


Ile Ser Arg Asp Phe Leu Pro Gly Gly Arg Arg Asp Tyr Thr Val Gln 
        195                 200                 205             


Val Gln Leu Arg Leu Cys Leu Ala Glu Thr Ser Cys Pro Gln Glu Asp 
    210                 215                 220                 


Asn Tyr Pro Asn Ser Leu Cys Ile Lys Val Asn Gly Lys Leu Phe Pro 
225                 230                 235                 240 


Leu Pro Gly Tyr Ala Pro Pro Pro Lys Asn Gly Ile Glu Gln Lys Arg 
                245                 250                 255     


Pro Gly Arg Pro Leu Asn Ile Thr Ser Leu Val Arg Leu Ser Ser Ala 
            260                 265                 270         


Val Pro Asn Gln Ile Ser Ile Ser Trp Ala Ser Glu Ile Gly Lys Asn 
        275                 280                 285             


Tyr Ser Met Ser Val Tyr Leu Val Arg Gln Leu Thr Ser Ala Met Leu 
    290                 295                 300                 


Leu Gln Arg Leu Lys Met Lys Gly Ile Arg Asn Pro Asp His Ser Arg 
305                 310                 315                 320 


Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Ile Ala 
                325                 330                 335     


Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg 
            340                 345                 350         


Leu Thr Ile Pro Cys Arg Ala Val Thr Cys Thr His Leu Gln Cys Phe 
        355                 360                 365             


Asp Ala Ala Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Ile 
    370                 375                 380                 


Cys Pro Val Cys Asp Lys Lys Ala Ala Tyr Glu Ser Leu Ile Leu Asp 
385                 390                 395                 400 


Gly Leu Phe Met Glu Ile Leu Asn Asp Cys Ser Asp Val Asp Glu Ile 
                405                 410                 415     


Lys Phe Gln Glu Asp Gly Ser Trp Cys Pro Met Arg Pro Lys Lys Glu 
            420                 425                 430         


Ala Met Lys Val Ser Ser Gln Pro Cys Thr Lys Ile Glu Ser Ser Ser 
        435                 440                 445             


Val Leu Ser Lys Pro Cys Ser Val Thr Val Ala Ser Glu Ala Ser Lys 
    450                 455                 460                 


Lys Lys Val Asp Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu 
465                 470                 475                 480 


Glu Glu Asp Pro Pro Ala Lys Arg Lys Cys Ile Phe Met Ser Glu Thr 
                485                 490                 495     


Gln Ser Ser Pro Thr Lys Gly Val Leu Met Tyr Gln Pro Ser Ser Val 
            500                 505                 510         


Arg Val Pro Ser Val Thr Ser Val Asp Pro Ala Ala Ile Pro Pro Ser 
        515                 520                 525             


Leu Thr Asp Tyr Ser Val Pro Phe His His Thr Pro Ile Ser Ser Met 
    530                 535                 540                 


Ser Ser Asp Leu Pro Gly Glu Gln Arg Arg Asn Asp Ile Asn Asn Glu 
545                 550                 555                 560 


Leu Lys Leu Gly Thr Ser Ser Asp Thr Val Gln Gln 
                565                 570         


<210>  24
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Asp Phe Glu Glu Leu Arg Asn Met Val Ser Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Asp Leu Leu Met Arg Ala Leu His Leu Leu Lys Ser Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Ile Lys Ile Arg Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Tyr Pro Arg Thr Leu Glu Gly Leu Ser Asp Leu Ser Thr Ile Lys Ser 
65                  70                  75                  80  


Ser Val Phe Ser Leu Asp Gly Gly Ser Ser Pro Val Glu Pro Asp Leu 
                85                  90                  95      


Ala Val Ala Gly Ile His Ser Leu Pro Ser Thr Ser Val Thr Pro His 
            100                 105                 110         


Ser Pro Ser Ser Pro Val Gly Ser Val Leu Leu Gln Asp Thr Lys Pro 
        115                 120                 125             


Thr Phe Glu Met Gln Gln Pro Ser Pro Pro Ile Pro Pro Val His Pro 
    130                 135                 140                 


Asp Val Gln Leu Lys Asn Leu Pro Phe Tyr Asp Val Leu Asp Val Leu 
145                 150                 155                 160 


Ile Lys Pro Thr Ser Leu Val Gln Ser Ser Ile Gln Arg Phe Gln Glu 
                165                 170                 175     


Lys Phe Phe Ile Phe Ala Leu Thr Pro Gln Gln Val Arg Glu Ile Cys 
            180                 185                 190         


Ile Ser Arg Asp Phe Leu Pro Gly Gly Arg Arg Asp Tyr Thr Val Gln 
        195                 200                 205             


Val Gln Leu Arg Leu Cys Leu Ala Glu Thr Ser Cys Pro Gln Glu Asp 
    210                 215                 220                 


Asn Tyr Pro Asn Ser Leu Cys Ile Lys Val Asn Gly Lys Leu Phe Pro 
225                 230                 235                 240 


Leu Pro Gly Tyr Ala Pro Pro Pro Lys Asn Gly Ile Glu Gln Lys Arg 
                245                 250                 255     


Pro Gly Arg Pro Leu Asn Ile Thr Ser Leu Val Arg Leu Ser Ser Ala 
            260                 265                 270         


Val Pro Asn Gln Ile Ser Ile Ser Trp Ala Ser Glu Ile Gly Lys Asn 
        275                 280                 285             


Tyr Ser Met Ser Val Tyr Leu Val Arg Gln Leu Thr Ser Ala Met Leu 
    290                 295                 300                 


Leu Gln Arg Leu Lys Met Lys Gly Ile Arg Asn Pro Asp His Ser Arg 
305                 310                 315                 320 


Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Ile Ala 
                325                 330                 335     


Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg 
            340                 345                 350         


Leu Thr Ile Pro Cys Arg Ala Val Thr Cys Thr His Leu Gln Cys Phe 
        355                 360                 365             


Asp Ala Ala Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Ile 
    370                 375                 380                 


Cys Pro Val Cys Asp Lys Lys Ala Ala Tyr Glu Ser Leu Ile Leu Asp 
385                 390                 395                 400 


Gly Leu Phe Met Glu Ile Leu Asn Asp Cys Ser Asp Val Asp Glu Ile 
                405                 410                 415     


Lys Phe Gln Glu Asp Gly Ser Trp Cys Pro Met Arg Pro Lys Lys Glu 
            420                 425                 430         


Ala Met Lys Val Ser Ser Gln Pro Cys Thr Lys Ile Glu Ser Ser Ser 
        435                 440                 445             


Val Leu Ser Lys Pro Cys Ser Val Thr Val Ala Ser Glu Ala Ser Lys 
    450                 455                 460                 


Lys Lys Val Asp Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu 
465                 470                 475                 480 


Glu Glu Asp Pro Pro Ala Lys Arg Lys Cys Ile Phe Met Ser Glu Thr 
                485                 490                 495     


Gln Ser Ser Pro Thr Lys Gly Val Leu Met Tyr Gln Pro Ser Ser Val 
            500                 505                 510         


Arg Val Pro Ser Val Thr Ser Val Asp Pro Ala Ala Ile Pro Pro Ser 
        515                 520                 525             


Leu Thr Asp Tyr Ser Val Pro Phe His His Thr Pro Ile Ser Ser Met 
    530                 535                 540                 


Ser Ser Asp Leu Pro Gly Leu Asp Phe Leu Ser Leu Ile Pro Val Asp 
545                 550                 555                 560 


Pro Gln Tyr Cys Pro Pro Met Phe Leu Asp Ser Leu Thr Ser Pro Leu 
                565                 570                 575     


Thr Ala Ser Ser Thr Ser Val Thr Thr Thr Ser Ser His Glu Ser Ser 
            580                 585                 590         


Thr His Val Ser Ser Ser Ser Ser Arg Ser Glu Thr Gly Val Ile Thr 
        595                 600                 605             


Ser Ser Gly Ser Asn Ile Pro Asp Ile Ile Ser Leu Asp 
    610                 615                 620     


<210>  25
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Glu Leu Gly Glu Leu Lys His Met Val Met Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Ala Lys Ala Leu His Leu Leu Lys Ser Ser 
        35                  40                  45              


Cys Ala Pro Ser Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Arg Lys Thr Leu Gly Pro Ser Asp Leu Ser Leu Leu Ser Leu 
65                  70                  75                  80  


Pro Pro Gly Thr Ser Pro Val Gly Ser Pro Gly Pro Leu Ala Pro Ile 
                85                  90                  95      


Pro Pro Thr Leu Leu Ala Pro Gly Thr Leu Leu Gly Pro Lys Arg Glu 
            100                 105                 110         


Val Asp Met His Pro Pro Leu Pro Gln Pro Val His Pro Asp Val Thr 
        115                 120                 125             


Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro 
    130                 135                 140                 


Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe 
145                 150                 155                 160 


Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile Leu Thr Ser Arg 
                165                 170                 175     


Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu 
            180                 185                 190         


Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro 
        195                 200                 205             


Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly 
    210                 215                 220                 


Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg 
225                 230                 235                 240 


Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn 
                245                 250                 255     


Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu 
            260                 265                 270         


Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys 
        275                 280                 285             


Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile 
    290                 295                 300                 


Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val Ala Thr Thr Ser 
305                 310                 315                 320 


Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg Leu Thr Val 
                325                 330                 335     


Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser Phe Asp Ala Ala 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Thr Cys Pro Val 
        355                 360                 365             


Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile Asp Gly Leu Phe 
    370                 375                 380                 


Met Glu Ile Leu Ser Ser Cys Ser Asp Cys Asp Glu Ile Gln Phe Met 
385                 390                 395                 400 


Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser Glu 
                405                 410                 415     


Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser Pro 
            420                 425                 430         


Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys Val Glu Val Ile 
        435                 440                 445             


Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro Thr 
    450                 455                 460                 


Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro Ala Leu Pro Gly 
465                 470                 475                 480 


Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu Arg 
                485                 490                 495     


Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu Ser Ser Leu Pro 
            500                 505                 510         


Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala Asp Ile Gln Gly 
        515                 520                 525             


Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln His Tyr Gly Pro 
    530                 535                 540                 


Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Ala Leu Gly His Phe Phe 
545                 550                 555                 560 


Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly Pro Leu Ala Pro Thr 
                565                 570                 575     


Leu Gly Ser Ser His Cys Ser Ala Thr Pro Ala Pro Pro Pro Gly Arg 
            580                 585                 590         


Val Ser Ser Ile Val Ala Pro Gly Gly Ala Leu Arg Glu Gly His Gly 
        595                 600                 605             


Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys Arg Ser Asp Ile 
    610                 615                 620                 


Ile Ser Leu Asp 
625             


<210>  26
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ala Glu Leu Val Glu Ala Lys Asn Met Val Met Ser Phe Arg 
1               5                   10                  15      


Val Ser Asp Leu Gln Met Leu Leu Gly Phe Val Gly Arg Ser Lys Ser 
            20                  25                  30          


Gly Leu Lys His Glu Leu Val Thr Arg Ala Leu Gln Leu Val Gln Phe 
        35                  40                  45              


Asp Cys Ser Pro Glu Leu Phe Lys Lys Ile Lys Glu Leu Tyr Glu Thr 
    50                  55                  60                  


Arg Tyr Ala Lys Lys Asn Ser Glu Pro Ala Pro Gln Pro His Arg Pro 
65                  70                  75                  80  


Leu Asp Pro Leu Thr Met His Ser Thr Tyr Asp Arg Ala Gly Ala Val 
                85                  90                  95      


Pro Arg Thr Pro Leu Ala Gly Pro Asn Ile Asp Tyr Pro Val Leu Tyr 
            100                 105                 110         


Gly Lys Tyr Leu Asn Gly Leu Gly Arg Leu Pro Ala Lys Thr Leu Lys 
        115                 120                 125             


Pro Glu Val Arg Leu Val Lys Leu Pro Phe Phe Asn Met Leu Asp Glu 
    130                 135                 140                 


Leu Leu Lys Pro Thr Glu Leu Val Pro Gln Asn Asn Glu Lys Leu Gln 
145                 150                 155                 160 


Glu Ser Pro Cys Ile Phe Ala Leu Thr Pro Arg Gln Val Glu Leu Ile 
                165                 170                 175     


Arg Asn Ser Arg Glu Leu Gln Pro Gly Val Lys Ala Val Gln Val Val 
            180                 185                 190         


Leu Arg Ile Cys Tyr Ser Asp Thr Ser Cys Pro Gln Glu Asp Gln Tyr 
        195                 200                 205             


Pro Pro Asn Ile Ala Val Lys Val Asn His Ser Tyr Cys Ser Val Pro 
    210                 215                 220                 


Gly Tyr Tyr Pro Ser Asn Lys Pro Gly Val Glu Pro Lys Arg Pro Cys 
225                 230                 235                 240 


Arg Pro Ile Asn Leu Thr His Leu Met Tyr Leu Ser Ser Ala Thr Asn 
                245                 250                 255     


Arg Ile Thr Val Thr Trp Gly Asn Tyr Gly Lys Ser Tyr Ser Val Ala 
            260                 265                 270         


Leu Tyr Leu Val Arg Gln Leu Thr Ser Ser Glu Leu Leu Gln Arg Leu 
        275                 280                 285             


Lys Thr Ile Gly Val Lys His Pro Glu Leu Cys Lys Ala Leu Val Lys 
    290                 295                 300                 


Glu Lys Leu Arg Leu Asp Pro Asp Ser Glu Ile Ala Thr Thr Gly Val 
305                 310                 315                 320 


Arg Val Ser Leu Ile Cys Pro Leu Val Lys Met Arg Leu Ser Val Pro 
                325                 330                 335     


Cys Arg Ala Glu Thr Cys Ala His Leu Gln Cys Phe Asp Ala Val Phe 
            340                 345                 350         


Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Met Cys Pro Val Cys 
        355                 360                 365             


Asp Lys Pro Ala Pro Tyr Asp Gln Leu Ile Ile Asp Gly Leu Leu Ser 
    370                 375                 380                 


Lys Ile Leu Ser Glu Cys Glu Asp Ala Asp Glu Ile Glu Tyr Leu Val 
385                 390                 395                 400 


Asp Gly Ser Trp Cys Pro Ile Arg Ala Glu Lys Glu Arg Ser Cys Ser 
                405                 410                 415     


Pro Gln Gly Ala Ile Leu Val Leu Gly Pro Ser Asp Ala Asn Gly Leu 
            420                 425                 430         


Leu Pro Ala Pro Ser Val Asn Gly Ser Gly Ala Leu Gly Ser Thr Gly 
        435                 440                 445             


Gly Gly Gly Pro Val Gly Ser Met Glu Asn Gly Lys Pro Gly Ala Asp 
    450                 455                 460                 


Val Val Asp Leu Thr Leu Asp Ser Ser Ser Ser Ser Glu Asp Glu Glu 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Gly Pro Arg Pro 
                485                 490                 495     


Lys Arg Arg Cys Pro Phe Gln Lys Gly Leu Val Pro Ala Cys 
            500                 505                 510 


<210>  27
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


<210>  28
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  29
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 
1               5                   10                  15      


Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 
            20                  25                  30          


Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His 
        35                  40                  45              


Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 
    50                  55                  60                  


Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 
65                  70                  75                  80  


Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 
                85                  90                  95      


Val Leu Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu 
            100                 105                 110         


Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile 
        115                 120                 125             


Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser Asp 
    130                 135                 140                 


Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly 
145                 150                 155                 160 


Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu 
                165                 170                 175     


Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala 
            180                 185                 190         


Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val 
        195                 200                 205             


Thr Arg Arg Arg Ile Arg Arg Thr Val Arg Arg Ala Leu Arg Arg Val 
    210                 215                 220                 


Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met 
225                 230                 235                 240 


Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val 
                245                 250                 255     


Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg 
            260                 265                 270         


Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val 
        275                 280                 285             


Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 
    290                 295                 300                 


Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 
305                 310                 315                 320 


Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 
            340                 345                 350         


Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 
        355                 360                 365             


Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 
    370                 375                 380                 


Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 
385                 390                 395                 400 


Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 
                405                 410                 415     


Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 
            420                 425                 430         


Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 
        435                 440                 445             


Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 
    450                 455                 460                 


Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 
465                 470                 475                 480 


Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr 
                485                 490                 495     


Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr 
            500                 505                 510         


Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly 
        515                 520                 525             


His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val 
    530                 535                 540                 


Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala 
545                 550                 555                 560 


Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met 
                565                 570                 575     


Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met 
            580                 585                 590         


Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile 
        595                 600                 605             


Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys 
    610                 615                 620                 


Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp 
625                 630                 635                 640 


Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala 
                645                 650                 655     


Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro 
            660                 665                 670         


Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile 
        675                 680                 685             


Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu 
    690                 695                 700                 


Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser 
705                 710                 715                 720 


Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln 
                725                 730                 735     


Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu 
            740                 745                 750         


Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro 
        755                 760                 765             


Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp 
    770                 775                 780                 


Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp 
785                 790                 795                 800 


Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile 
                805                 810                 815     


Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn 
            820                 825                 830         


Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr 
        835                 840                 845             


Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln 
    850                 855                 860                 


Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser 
865                 870                 875                 880 


Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Gln 
                885                 890                 895     


Ser Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp 
            900                 905                 910         


Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu 
        915                 920                 925             


Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg 
    930                 935                 940                 


Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu 
945                 950                 955                 960 


Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu 
                965                 970                 975     


Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe 
            980                 985                 990         


Trp Tyr Ala Pro Glu Ser Leu Ser  Asp Asn Ile Phe Ser  Arg Gln Ser 
        995                 1000                 1005             


Asp Val  Trp Ser Phe Gly Val  Val Leu Tyr Glu Leu  Phe Thr Tyr 
    1010                 1015                 1020             


Cys Asp  Lys Ser Cys Ser Pro  Ser Ala Glu Phe Leu  Arg Met Met 
    1025                 1030                 1035             


Gly Cys  Glu Arg Asp Val Pro  Ala Leu Cys Arg Leu  Leu Glu Leu 
    1040                 1045                 1050             


Leu Glu  Glu Gly Gln Arg Leu  Pro Ala Pro Pro Ala  Cys Pro Ala 
    1055                 1060                 1065             


Glu Val  His Glu Leu Met Lys  Leu Cys Trp Ala Pro  Ser Pro Gln 
    1070                 1075                 1080             


Asp Arg  Pro Ser Phe Ser Ala  Leu Gly Pro Gln Leu  Asp Met Leu 
    1085                 1090                 1095             


Trp Ser  Gly Ser Arg Gly Cys  Glu Thr His Ala Phe  Thr Ala His 
    1100                 1105                 1110             


Pro Glu  Gly Lys His His Ser  Leu Ser Phe Ser 
    1115                 1120                 


<210>  30
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


