                         SEQUENCE LISTING

<110>  New England Biolabs, Inc.
       Zhu, Zhenyu
       Quimby, Aine
       Guan, Shengxi
       Sun, Dapeng
       Huang, Yishu
       Lai, Xuhui
       Chan, Siu-hong
       Li, Xianghui
       Xu, Shuang-yong
       Zhang, Chunhua
 
<120>  High Fidelity Restriction Endonucleases

<130>  NEB-331-PCT

<150>  61/301,666
<151>  2010-02-05

<150>  61/387,800
<151>  2010-09-29

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  218
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  1

Met Asp Val Phe Asp Lys Val Tyr Ser Asp Asp Asn Asn Ser Tyr Asp 
1               5                   10                  15      


Gln Lys Thr Val Ser Gln Arg Ile Glu Ala Leu Phe Leu Asn Asn Leu 
            20                  25                  30          


Gly Lys Val Val Thr Arg Gln Gln Ile Ile Arg Ala Ala Thr Asp Pro 
        35                  40                  45              


Lys Thr Gly Lys Gln Pro Glu Asn Trp His Gln Arg Leu Ser Glu Leu 
    50                  55                  60                  


Arg Thr Asp Lys Gly Tyr Thr Ile Leu Ser Trp Arg Asp Met Lys Val 
65                  70                  75                  80  


Leu Ala Pro Gln Glu Tyr Ile Met Pro His Ala Thr Arg Arg Pro Lys 
                85                  90                  95      


Ala Ala Lys Arg Val Leu Pro Thr Lys Glu Thr Trp Glu Gln Val Leu 
            100                 105                 110         


Asp Arg Ala Asn Tyr Ser Cys Glu Trp Gln Glu Asp Gly Gln His Cys 
        115                 120                 125             


Gly Leu Val Glu Gly Asp Ile Asp Pro Ile Gly Gly Gly Thr Val Lys 
    130                 135                 140                 


Leu Thr Pro Asp His Met Thr Pro His Ser Ile Asp Pro Ala Thr Asp 
145                 150                 155                 160 


Val Asn Asp Pro Lys Met Trp Gln Ala Leu Cys Gly Arg His Gln Val 
                165                 170                 175     


Met Lys Lys Asn Tyr Trp Asp Ser Asn Asn Gly Lys Ile Asn Val Ile 
            180                 185                 190         


Gly Ile Leu Gln Ser Val Asn Glu Lys Gln Lys Asn Asp Ala Leu Glu 
        195                 200                 205             


Phe Leu Leu Asn Tyr Tyr Gly Leu Lys Arg 
    210                 215             


<210>  2
<211>  355
<212>  PRT
<213>  Salmonella typhi

<400>  2

Met Asn Phe Lys Asp Lys Asn Cys Phe Pro Asn Glu Leu Ile Ala Leu 
1               5                   10                  15      


Ala Lys Ile Ser Lys Asn Asp Val Leu Asp Lys Phe Gly Thr Asp Val 
            20                  25                  30          


Phe Lys Lys Val Val Tyr Asp Val Leu Thr Gly Lys Asn Val Arg Glu 
        35                  40                  45              


Phe Thr Glu Ile Leu Thr Arg Thr Arg Leu Leu Glu Ser Asn Leu Ser 
    50                  55                  60                  


Phe Phe Asp Phe Phe Val Asp Lys Met Lys Glu Gly Ile Thr Pro Lys 
65                  70                  75                  80  


Gln Leu Tyr Leu Tyr Ala Lys Asn Ala Leu Ser Asn Lys Ser Tyr Val 
                85                  90                  95      


Lys Tyr Asn Gln Pro Val Leu Glu Trp Met Val Met Met Thr Asn Lys 
            100                 105                 110         


Gln Thr Gln Asn Val Leu Arg Asp Glu His Gly Asp Gly Phe Asp Arg 
        115                 120                 125             


Leu Ala Leu Arg Thr Gln Glu Glu Ile Leu Lys Ile Lys Asn Gly Tyr 
    130                 135                 140                 


Glu Asp Lys Ile Gly Glu Ile Ser Ile Gly Gly Gln Lys Val Ser Leu 
145                 150                 155                 160 


Glu Asp Phe Cys Tyr Ile Ile Leu Ser Leu Gly Ser Gln Thr Leu Thr 
                165                 170                 175     


Ile Arg Gly Ser Glu Lys Ser Leu His Gly Lys Tyr Phe Glu Lys Leu 
            180                 185                 190         


Ile Leu Gly Ser Leu Phe Thr Ile Met Gly Phe Glu Tyr Lys Glu Lys 
        195                 200                 205             


Ile Glu Glu Gly Leu Asn Ala Lys Cys Phe Thr Leu Ser Thr Arg Ala 
    210                 215                 220                 


Asp Asp Arg Glu Ser Asp Ala Thr Leu Ile Phe Asn Gly Lys Ala Ile 
225                 230                 235                 240 


Arg Val Asp Ile Gly Phe Ile Gly Arg Gly Asn Thr Glu Ile Ser Leu 
                245                 250                 255     


Asp Lys Val Ser Arg Phe Arg Arg Met Asp Asp Ile Gly Gly Val Met 
            260                 265                 270         


His Asn Ile Ser Thr Met Val Ile Val Asp Val Ile Gly Asp Arg Ser 
        275                 280                 285             


Arg Ile Val Asn Met Ala Glu Glu Ile Asp Gly Lys Val Val Ala Met 
    290                 295                 300                 


Ser Asp Pro Tyr Trp Val Ala Lys Val Ser Ser Tyr Ile Ser Ser Lys 
305                 310                 315                 320 


Leu Asn Val Asp Asp Leu Leu Glu Asp Lys Pro Gln Leu Lys Tyr Ile 
                325                 330                 335     


Gln Ser Phe Ile Ser Asp Ala Leu Glu Asn Val Asp Leu Glu Lys Tyr 
            340                 345                 350         


Ile Lys Leu 
        355 


<210>  3
<211>  300
<212>  PRT
<213>  Haemophilus influenzae

<400>  3

Met Lys Lys Ser Ala Leu Glu Lys Leu Leu Ser Leu Ile Glu Asn Leu 
1               5                   10                  15      


Thr Asn Gln Glu Phe Lys Gln Ala Thr Asn Ser Leu Ile Ser Phe Ile 
            20                  25                  30          


Tyr Lys Leu Asn Arg Asn Glu Val Ile Glu Leu Val Arg Ser Ile Gly 
        35                  40                  45              


Ile Leu Pro Glu Ala Ile Lys Pro Ser Ser Thr Gln Glu Lys Leu Phe 
    50                  55                  60                  


Ser Lys Ala Gly Asp Ile Val Leu Ala Lys Ala Phe Gln Leu Leu Asn 
65                  70                  75                  80  


Leu Asn Ser Lys Pro Leu Glu Gln Arg Gly Asn Ala Gly Asp Val Ile 
                85                  90                  95      


Ala Leu Ser Lys Glu Phe Asn Tyr Gly Leu Val Ala Asp Ala Lys Ser 
            100                 105                 110         


Phe Arg Leu Ser Arg Thr Ala Lys Asn Gln Lys Asp Phe Lys Val Lys 
        115                 120                 125             


Ala Leu Ser Glu Trp Arg Glu Asp Lys Asp Tyr Ala Val Leu Thr Ala 
    130                 135                 140                 


Pro Phe Phe Gln Tyr Pro Thr Thr Lys Ser Gln Ile Phe Lys Gln Ser 
145                 150                 155                 160 


Leu Asp Glu Asn Val Leu Leu Phe Ser Trp Glu His Leu Ala Ile Leu 
                165                 170                 175     


Leu Gln Leu Asp Leu Glu Glu Thr Asn Ile Phe Pro Phe Glu Gln Leu 
            180                 185                 190         


Trp Asn Phe Pro Lys Lys Gln Ser Lys Lys Thr Ser Val Ser Asp Ala 
        195                 200                 205             


Glu Asn Asn Phe Met Arg Asp Phe Asn Lys Tyr Phe Met Asp Leu Phe 
    210                 215                 220                 


Lys Ile Asp Lys Asp Thr Leu Asn Gln Leu Leu Gln Lys Glu Ile Asn 
225                 230                 235                 240 


Phe Ile Glu Glu Arg Ser Leu Ile Glu Lys Glu Tyr Trp Lys Lys Gln 
                245                 250                 255     


Ile Asn Ile Ile Lys Asn Phe Thr Arg Glu Glu Ala Ile Glu Ala Leu 
            260                 265                 270         


Leu Lys Asp Ile Asn Met Ser Ser Lys Ile Glu Thr Ile Asp Ser Phe 
        275                 280                 285             


Ile Lys Gly Ile Lys Ser Asn Asp Arg Leu Tyr Leu 
    290                 295                 300 


<210>  4
<211>  260
<212>  PRT
<213>  Proteus vulgaris

<400>  4

Met Lys Lys Asn Arg Tyr Glu Ser Ile Ile Glu Gly Ile Phe Leu Asp 
1               5                   10                  15      


Lys Tyr Val Asp Gly Asn Asp Ile Val Glu Phe Asn Arg Thr Asp Ile 
            20                  25                  30          


Ile Ser Lys Ser Ala Glu Leu Asp Ile Asn Leu Pro Lys Asn Ile Gly 
        35                  40                  45              


Asp Val Ile Tyr Ser Phe Lys Tyr Arg Ala Ser Leu Pro Val Ser Ile 
    50                  55                  60                  


Thr Gln Lys Ala Gln Asn Gly Lys Glu Trp Val Ile Lys Asn Ile Gly 
65                  70                  75                  80  


Arg Ser Leu Tyr Cys Phe Gln Gln Val Asn Tyr Ser Arg Ile Leu Pro 
                85                  90                  95      


Asp Met Met Leu Ser Thr Ile Lys Ile Pro Asp Ser Thr Pro Thr Ile 
            100                 105                 110         


Val Ala Glu His Ala Phe Asn Asp Glu Gln Ala Leu Leu Thr Arg Val 
        115                 120                 125             


Arg Tyr Asn Arg Leu Ile Asp Ile Phe Thr Gly Ala Val Cys Tyr Ser 
    130                 135                 140                 


Leu Gln Asn His Leu Arg Thr Thr Val Pro Ser Val Gly Gln Ile Glu 
145                 150                 155                 160 


Thr Asp Glu Ile Tyr Val Gly Val Asp Arg Leu Gly Arg Gln Phe Ile 
                165                 170                 175     


Phe Pro Val Gln Ala Lys Gly Gly Lys Asp Glu Leu Gly Ile Val Gln 
            180                 185                 190         


Ile Glu Gln Asp Phe Leu Leu Cys Arg His Lys Tyr Pro Asn Leu Ile 
        195                 200                 205             


Cys Arg Pro Ile Ala Thr Gln Phe Ile Ser Asn Asp Lys Ile Ala Ile 
    210                 215                 220                 


Phe Glu Phe Val Leu Glu Asn Asn Glu Val Lys Lys Leu Gln Glu Lys 
225                 230                 235                 240 


His Tyr Leu Leu Val Gly Lys Gly Gln Ile Ser Val Asp Glu Leu Ser 
                245                 250                 255     


Asn Tyr Asn Phe 
            260 


<210>  5
<211>  227
<212>  PRT
<213>  Deinococcus radiophilus

<400>  5

Met Glu Leu Cys His Lys Thr Val Lys Ser Arg Thr Ala Tyr Ser Lys 
1               5                   10                  15      


His Phe Pro His Lys Cys Gln Leu Pro Leu Gly His Ser Gly Lys Cys 
            20                  25                  30          


Leu Glu Phe Pro Phe Leu Val Ser Leu Ser Lys Thr His Pro Arg Ile 
        35                  40                  45              


Ala Ala Lys Ile Val Arg Asp Ala Thr Met Thr Thr Gly Ala Ala Trp 
    50                  55                  60                  


Lys Ser Ser Gln Ala Gly Pro Asn Arg Met Pro Arg Tyr Val Ala Ile 
65                  70                  75                  80  


Leu Asp Asp Asp Ile Leu Leu Glu Lys Phe Asn Leu Asp Met Gln Ser 
                85                  90                  95      


Leu Pro Glu Ile Thr Arg Leu Lys Ile Arg Glu Lys Ala Ala Asp Tyr 
            100                 105                 110         


Asp Ser Cys Ile Asp Val Ala Arg Lys Leu Thr Trp Leu Ala Tyr Gln 
        115                 120                 125             


Leu His Gly Ala Pro Ile Pro Asp Ser Phe Thr Lys Asn Tyr Leu Glu 
    130                 135                 140                 


Glu Phe Phe Gly Pro Met Val Ala Gly Ser Thr Asn Cys Glu Ile Cys 
145                 150                 155                 160 


Lys Leu Pro Leu Thr Ile Asp Leu Phe Ser Glu Asn Arg Val Gly Lys 
                165                 170                 175     


Ala Ala Val Glu Thr Ala His Lys Thr Pro Arg Leu His Asn Ala Glu 
            180                 185                 190         


Asn Val Gly Phe Ala His Arg Phe Cys Asn Val Ala Gln Gly Asn Lys 
        195                 200                 205             


Ser Leu Asp Glu Phe Tyr Leu Trp Met Glu Glu Val Leu Thr Arg Val 
    210                 215                 220                 


Lys Met Leu 
225         


<210>  6
<211>  307
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  6

Met Thr Phe Asp Lys Ile Ala Val Lys Gln Ile Leu Leu Arg Leu Leu 
1               5                   10                  15      


Lys Gly Glu Asp Tyr Arg Gly Glu Val Leu Asn Ile Ile Asn Ala Asp 
            20                  25                  30          


Phe Leu Asp Phe Ala Leu Gln Phe Phe Lys Asp Val Ala Leu Ala Lys 
        35                  40                  45              


Leu Gln Asn Glu Glu Leu Thr Asp Asp Trp Tyr Lys Lys Tyr Phe Ile 
    50                  55                  60                  


Gln Asn Pro Ser Leu Thr Lys Glu Lys Val Ala Ile Tyr Ser Gly Leu 
65                  70                  75                  80  


Asn Met Lys Thr Ile Ser Asn Thr Tyr Lys Thr Thr Ala Lys Asn Val 
                85                  90                  95      


Val Val Asp Ala Ser Leu Glu His Tyr Asp Ala Phe Val Lys Thr Ile 
            100                 105                 110         


Gln Glu Leu Ile Glu Ile Asp Asp Ser Leu Glu Leu Met Leu Thr Ile 
        115                 120                 125             


Lys Tyr Asn Lys Val Ser Val Glu Leu Thr Leu Ser Glu Ser Leu Ile 
    130                 135                 140                 


Val Met Asn Val Leu Ala Val Lys Arg Ala Ala Ile Arg Gly Gly Ala 
145                 150                 155                 160 


Trp Ser Thr Ala Gly Lys Arg Val Glu Lys Leu Leu Met Leu Thr Leu 
                165                 170                 175     


Cys Lys Leu Phe Arg Val Pro Asp Lys His Tyr Lys Ser Ile Tyr Val 
            180                 185                 190         


Ala Gln Leu Lys Asp Glu Asn Asp Phe Ser Arg Glu Ile Asp Phe Tyr 
        195                 200                 205             


Leu Ile Asp Gln Asn Asn Asn Glu Leu Lys Cys Glu Val Lys Leu Met 
    210                 215                 220                 


Gly Lys Gly Asn Pro Glu Ser Ala Asp Ala Val Ile Ala Arg Asp Ser 
225                 230                 235                 240 


Lys Ile Phe Val Ala Asp Thr Leu Ser Glu Thr Asn Lys Lys Gln Leu 
                245                 250                 255     


Asp Phe Leu Lys Val Glu Trp Val Glu Leu Arg Ser Glu Lys Gly Tyr 
            260                 265                 270         


Glu Lys Phe Lys Thr Ile Leu Ser Asn Arg Gly Ile Pro Tyr Glu Asp 
        275                 280                 285             


Ile Glu Glu Ile Thr Pro Glu Tyr Leu Glu Lys Val Ile Asp Glu Ser 
    290                 295                 300                 


Leu Gly Ile 
305         


<210>  7
<211>  272
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  7

Met Asn Phe Phe Glu Tyr Cys Ile Ser Thr Tyr Ala Lys Ile Phe Glu 
1               5                   10                  15      


Glu Thr Met Asn Ala Val Gly Asp Glu Arg Val Ser Gln Lys Lys Ala 
            20                  25                  30          


Ile Arg Asp Thr Met Ile Ser Ala Met Arg Glu Phe Pro Asn Val Glu 
        35                  40                  45              


Ala Ala Glu Ile Trp Lys Ala Val Tyr Ser Ala His Met Asp Arg Lys 
    50                  55                  60                  


Ser Gly Ile Ala Asp Pro Asp Ile Ile Gln Lys Val Ile Ser Ala Glu 
65                  70                  75                  80  


Asn Ser Trp Lys Lys Ser Ser Gly His Ala Phe Glu Glu Met Ile Lys 
                85                  90                  95      


Leu Leu Gly Asn Ser Ser Leu Glu Glu Tyr Gly Met Arg Ile Leu Leu 
            100                 105                 110         


Gln Lys Asp Leu Asn Met Met Ile Glu Asn Gln Glu Ile Ala Asn Glu 
        115                 120                 125             


Pro Arg Asp Ile Asn Trp Leu Lys Glu Gln Ile Ser Ser Asn Val Phe 
    130                 135                 140                 


Asp Leu Tyr Ile Thr Val Arg Asn Asn Asp Lys Glu Tyr Val Phe Gly 
145                 150                 155                 160 


Cys Ile Gln Ser Lys Thr Ser Ile Arg Asp Arg Val Thr Arg Asp Arg 
                165                 170                 175     


Glu Pro Ser Met Lys Ala Met Glu Ala Phe Phe Trp Ser Val Ala Ile 
            180                 185                 190         


Cys Leu Asp Gly Asp Phe Leu Lys Met Pro Lys Phe Ile Ala Met Val 
        195                 200                 205             


Asn Gly Gly Thr Ser Asn Tyr Arg Leu Asn Gly Trp His Gly Met Tyr 
    210                 215                 220                 


Val Phe Trp Asp Lys Pro Thr Ile Asp Arg Ile Tyr Pro Ile Asp Ile 
225                 230                 235                 240 


Asn Leu Glu Leu Phe Val Gln His Ala Arg Glu Ala Ala Glu Asp Trp 
                245                 250                 255     


Leu His Arg Arg Gln Trp Phe Asn Tyr Glu Trp Lys Ala Gly Gln Lys 
            260                 265                 270         


<210>  8
<211>  299
<212>  PRT
<213>  Bacillus globigii

<400>  8

Met Tyr Asn Leu His Arg Glu Lys Ile Phe Met Ser Tyr Asn Gln Asn 
1               5                   10                  15      


Lys Gln Tyr Leu Glu Asp Asn Pro Glu Ile Gln Glu Lys Ile Glu Leu 
            20                  25                  30          


Tyr Gly Leu Asn Leu Leu Asn Glu Val Ile Ser Asp Asn Glu Glu Glu 
        35                  40                  45              


Ile Arg Ala Asp Tyr Asn Glu Ala Asn Phe Leu His Pro Phe Trp Met 
    50                  55                  60                  


Asn Tyr Pro Pro Leu Asp Arg Gly Lys Met Pro Lys Gly Asp Gln Ile 
65                  70                  75                  80  


Pro Trp Ile Glu Val Gly Glu Lys Ala Val Gly Ser Lys Leu Thr Arg 
                85                  90                  95      


Leu Val Ser Gln Arg Glu Asp Ile Thr Val Arg Glu Ile Gly Leu Pro 
            100                 105                 110         


Thr Gly Pro Asp Glu Arg Tyr Leu Leu Thr Ser Pro Thr Ile Tyr Ser 
        115                 120                 125             


Leu Thr Asn Gly Phe Thr Asp Ser Ile Met Met Phe Val Asp Ile Lys 
    130                 135                 140                 


Ser Val Gly Pro Arg Asp Ser Asp Tyr Asp Leu Val Leu Ser Pro Asn 
145                 150                 155                 160 


Gln Val Ser Gly Asn Gly Asp Trp Ala Gln Leu Glu Gly Gly Ile Gln 
                165                 170                 175     


Asn Asn Gln Gln Thr Ile Gln Gly Pro Arg Ser Ser Gln Ile Phe Leu 
            180                 185                 190         


Pro Thr Ile Pro Pro Leu Tyr Ile Leu Ser Asp Gly Thr Ile Ala Pro 
        195                 200                 205             


Val Val His Leu Phe Ile Lys Pro Ile Tyr Ala Met Arg Ser Leu Thr 
    210                 215                 220                 


Lys Gly Asp Thr Gly Gln Ser Leu Tyr Lys Ile Lys Leu Ala Ser Val 
225                 230                 235                 240 


Pro Asn Gly Leu Gly Leu Phe Cys Asn Pro Gly Tyr Ala Phe Asp Ser 
                245                 250                 255     


Ala Tyr Lys Phe Leu Phe Arg Pro Gly Lys Asp Asp Arg Thr Lys Ser 
            260                 265                 270         


Leu Leu Gln Lys Arg Val Arg Val Asp Leu Arg Val Leu Asp Lys Ile 
        275                 280                 285             


Gly Pro Arg Val Met Thr Ile Asp Met Asp Lys 
    290                 295                 


<210>  9
<211>  533
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  9

Met Thr Glu Tyr Asp Leu His Leu Tyr Ala Asp Ser Phe His Glu Gly 
1               5                   10                  15      


His Trp Cys Cys Glu Asn Leu Ala Lys Ile Ala Gln Ser Asp Gly Gly 
            20                  25                  30          


Lys His Gln Ile Asp Tyr Leu Gln Gly Phe Ile Pro Arg His Ser Leu 
        35                  40                  45              


Ile Phe Ser Asp Leu Ile Ile Asn Ile Thr Val Phe Gly Ser Tyr Lys 
    50                  55                  60                  


Ser Trp Lys His Leu Pro Lys Gln Ile Lys Asp Leu Leu Phe Trp Gly 
65                  70                  75                  80  


Lys Pro Asp Phe Ile Ala Tyr Asp Pro Lys Asn Asp Lys Ile Leu Phe 
                85                  90                  95      


Ala Val Glu Glu Thr Gly Ala Val Pro Thr Gly Asn Gln Ala Leu Gln 
            100                 105                 110         


Arg Cys Glu Arg Ile Tyr Gly Ser Ala Arg Lys Gln Ile Pro Phe Trp 
        115                 120                 125             


Tyr Leu Leu Ser Glu Phe Gly Gln His Lys Asp Gly Gly Thr Arg Arg 
    130                 135                 140                 


Asp Ser Ile Trp Pro Thr Ile Met Gly Leu Lys Leu Thr Gln Leu Val 
145                 150                 155                 160 


Lys Thr Pro Ser Ile Ile Leu His Tyr Ser Asp Ile Asn Asn Pro Glu 
                165                 170                 175     


Asp Tyr Asn Ser Gly Asn Gly Leu Lys Phe Leu Phe Lys Ser Leu Leu 
            180                 185                 190         


Gln Ile Ile Ile Asn Tyr Cys Thr Leu Lys Asn Pro Leu Lys Gly Met 
        195                 200                 205             


Leu Glu Leu Leu Ser Ile Gln Tyr Glu Asn Met Leu Glu Phe Ile Lys 
    210                 215                 220                 


Ser Gln Trp Lys Glu Gln Ile Asp Phe Leu Pro Gly Glu Glu Ile Leu 
225                 230                 235                 240 


Asn Thr Lys Thr Lys Glu Leu Ala Arg Met Tyr Ala Ser Leu Ala Ile 
                245                 250                 255     


Gly Gln Thr Val Lys Ile Pro Glu Glu Leu Phe Asn Trp Pro Arg Thr 
            260                 265                 270         


Asp Lys Val Asn Phe Lys Ser Pro Gln Gly Leu Ile Lys Tyr Asp Glu 
        275                 280                 285             


Leu Cys Tyr Gln Leu Glu Lys Ala Val Gly Ser Lys Lys Ala Tyr Cys 
    290                 295                 300                 


Leu Ser Asn Asn Ala Gly Ala Lys Pro Gln Lys Leu Glu Ser Leu Lys 
305                 310                 315                 320 


Glu Trp Ile Asn Ser Gln Lys Lys Leu Phe Asp Lys Ala Pro Lys Leu 
                325                 330                 335     


Thr Pro Pro Ala Glu Phe Asn Met Lys Leu Asp Ala Phe Pro Val Thr 
            340                 345                 350         


Ser Asn Asn Asn Tyr Tyr Val Thr Thr Ser Lys Asn Ile Leu Tyr Leu 
        355                 360                 365             


Phe Asp Tyr Trp Lys Asp Leu Arg Ile Ala Ile Glu Thr Ala Phe Pro 
    370                 375                 380                 


Arg Leu Lys Gly Lys Leu Pro Thr Asp Ile Asp Glu Lys Pro Ala Leu 
385                 390                 395                 400 


Ile Tyr Ile Cys Asn Ser Val Lys Pro Gly Arg Leu Phe Gly Asp Pro 
                405                 410                 415     


Phe Thr Gly Gln Leu Ser Ala Phe Ser Thr Ile Phe Gly Lys Lys Asn 
            420                 425                 430         


Ile Asp Met Pro Arg Ile Val Val Ala Tyr Tyr Pro His Gln Ile Tyr 
        435                 440                 445             


Ser Gln Ala Leu Pro Lys Asn Asn Lys Ser Asn Lys Gly Ile Thr Leu 
    450                 455                 460                 


Lys Lys Glu Leu Thr Asp Phe Leu Ile Phe His Gly Gly Val Val Val 
465                 470                 475                 480 


Lys Leu Asn Glu Gly Lys Ala Tyr Pro His Gln Ile Tyr Ser Gln Ala 
                485                 490                 495     


Leu Pro Lys Asn Asn Lys Ser Asn Lys Gly Ile Thr Leu Lys Lys Glu 
            500                 505                 510         


Leu Thr Asp Phe Leu Ile Phe His Gly Gly Val Val Val Lys Leu Asn 
        515                 520                 525             


Glu Gly Lys Ala Tyr 
    530             


<210>  10
<211>  383
<212>  PRT
<213>  Neisseria sicca

<400>  10

Met Ile Asn His Ser Ile Leu Lys His His Ser Phe Thr Gly Lys Ile 
1               5                   10                  15      


Ile Ser Ile Leu Lys Asp Glu Phe Gly Asp Asp Ala Ile Tyr Ile Phe 
            20                  25                  30          


Glu Asn Ser Pro Ile Leu Gly Tyr Leu Asn Ile Lys Thr Lys Ser Ala 
        35                  40                  45              


Glu Arg Gly Ser Lys Ser Arg Gly Ser Phe Ala Asn His Tyr Ala Leu 
    50                  55                  60                  


Tyr Val Ile Ile Glu Asp Tyr Ile Asn Lys Gly Tyr Leu Gly Asp Asp 
65                  70                  75                  80  


Leu Asp Tyr Ser Lys Tyr Asp Gly Ala Lys Phe Thr Asp Leu Phe Arg 
                85                  90                  95      


Arg Gln Arg Glu Leu Pro Phe Gly Ser Lys Leu Gln Asn His Ala Leu 
            100                 105                 110         


Asn Ser Arg Leu Asn Asp Glu Phe Lys Lys Phe Phe Pro Thr Leu Gly 
        115                 120                 125             


Ile Val Pro Ile Ile Arg Asp Val Arg Thr Ser Arg Tyr Trp Ile Gln 
    130                 135                 140                 


Glu Asp Leu Ile Lys Val Ser Val Arg Asn Lys Asn Gly Ile Glu Arg 
145                 150                 155                 160 


Arg Glu Asn Leu Ala Pro Ser Ile Ile Arg Ile Ile Asp Glu Tyr Ile 
                165                 170                 175     


Ala Thr Lys Lys Glu Ser Phe Glu Leu Phe Leu Lys Thr Cys Gln Glu 
            180                 185                 190         


Ile Ala Asn Leu Ser Ser Ser Asp Pro His Ser Val Val Lys Phe Ile 
        195                 200                 205             


Gln Glu Gln Leu His Pro Ser Ser Asp Ala Arg Val Phe Glu Ile Val 
    210                 215                 220                 


Ser Tyr Ala Val Leu Lys Glu Arg Tyr Ser Asn Gln Thr Ile Trp Ile 
225                 230                 235                 240 


Gly Asp Ser Arg Asp Asp Val Ala Glu Glu Ser Leu Val Leu Tyr Lys 
                245                 250                 255     


Thr Gly Arg Thr Asn Ala Asn Asp Gly Gly Ile Asp Phe Val Met Lys 
            260                 265                 270         


Pro Leu Gly Arg Phe Phe Gln Val Thr Glu Thr Ile Asp Ala Asn Lys 
        275                 280                 285             


Tyr Phe Leu Asp Ile Asp Lys Val Gln Arg Phe Pro Ile Thr Phe Val 
    290                 295                 300                 


Val Lys Thr Asn Ser Ser Tyr Glu Glu Ile Glu Lys Ile Ile Lys Glu 
305                 310                 315                 320 


Gln Ala Lys Ala Lys Tyr Asn Ile Glu Ala Ile Val Asn Ser Tyr Met 
                325                 330                 335     


Asp Ser Ile Glu Glu Ile Ile Asn Val Pro Asp Leu Met Lys Tyr Phe 
            340                 345                 350         


Glu Glu Met Ile Tyr Ser Asp Ser Leu Lys Arg Ile Met Asp Glu Ile 
        355                 360                 365             


Ile Val Gln Ser Lys Val Glu Phe Asn Tyr Glu Glu Asp Val Ser 
    370                 375                 380             


<210>  11
<211>  288
<212>  PRT
<213>  Diplococcus pneumoniae

<400>  11

Met Lys Gln Thr Arg Asn Phe Asp Glu Trp Leu Ser Thr Met Thr Asp 
1               5                   10                  15      


Thr Val Ala Asp Trp Thr Tyr Tyr Thr Asp Phe Pro Lys Val Tyr Lys 
            20                  25                  30          


Asn Val Ser Ser Ile Lys Val Ala Leu Asn Ile Met Asn Ser Leu Ile 
        35                  40                  45              


Gly Ser Lys Asn Ile Gln Glu Asp Phe Leu Asp Leu Tyr Gln Asn Tyr 
    50                  55                  60                  


Pro Glu Ile Leu Lys Val Val Pro Leu Leu Ile Ala Lys Arg Leu Arg 
65                  70                  75                  80  


Asp Thr Ile Ile Val Lys Asp Pro Ile Lys Asp Phe Tyr Phe Asp Phe 
                85                  90                  95      


Ser Lys Arg Asn Tyr Ser Ile Glu Glu Tyr Thr Met Phe Leu Glu Lys 
            100                 105                 110         


Ser Gly Ile Phe Asp Leu Leu Gln Asn His Leu Val Ser Asn Leu Val 
        115                 120                 125             


Asp Tyr Val Thr Gly Val Glu Val Gly Met Asp Thr Asn Gly Arg Lys 
    130                 135                 140                 


Asn Arg Thr Gly Asp Ala Met Glu Asn Ile Val Gln Ser Tyr Leu Glu 
145                 150                 155                 160 


Ala Glu Gly Tyr Ile Leu Gly Glu Asn Leu Phe Lys Glu Ile Glu Gln 
                165                 170                 175     


Asn Glu Ile Glu Glu Ile Phe Ser Val Asp Leu Ser Ala Ile Thr Asn 
            180                 185                 190         


Asp Gly Asn Thr Val Lys Arg Phe Asp Phe Val Ile Lys Asn Glu Gln 
        195                 200                 205             


Val Leu Tyr Leu Ile Glu Val Asn Phe Tyr Ser Gly Ser Gly Ser Lys 
    210                 215                 220                 


Leu Asn Glu Thr Ala Arg Ser Tyr Lys Met Ile Ala Glu Glu Thr Lys 
225                 230                 235                 240 


Ala Ile Pro Asn Val Glu Phe Met Trp Ile Thr Asp Gly Gln Gly Trp 
                245                 250                 255     


Tyr Lys Ala Lys Asn Asn Leu Arg Glu Thr Phe Asp Ile Leu Pro Phe 
            260                 265                 270         


Leu Tyr Asn Ile Asn Asp Leu Glu His Asn Ile Leu Lys Asn Leu Lys 
        275                 280                 285             


<210>  12
<211>  285
<212>  PRT
<213>  Bacillus caldolyticus

<400>  12

Met Gln Pro Asn Pro Lys Phe Ile Asn Lys Ser Ser Ala Phe Trp Ala 
1               5                   10                  15      


Tyr Ala Lys Leu Leu Ser Glu Gln Leu Gly Tyr Ser Lys Asp Gly Val 
            20                  25                  30          


Val Ile Ser Tyr Ser Glu Ala Gln Ala Arg Ala Lys Leu Lys Lys Leu 
        35                  40                  45              


Gly Ile Asn Val Lys Glu Gly Ile Phe Lys Asp Val Leu Arg Tyr Leu 
    50                  55                  60                  


Lys Tyr Arg Ala Glu Leu Leu Asn Lys His Lys Asp Tyr Leu Met Asp 
65                  70                  75                  80  


Val Glu Glu Ala Arg Lys Tyr Phe Gln Val Ala Leu Lys Gln His Gln 
                85                  90                  95      


Gln Asn Asn Tyr Thr Cys Lys Leu Pro Leu Asn Lys Gln Lys Asn Glu 
            100                 105                 110         


Lys Lys Asp Tyr Ala Tyr Phe Thr Cys Ile Ile Asn Ile Ile Ala Glu 
        115                 120                 125             


Thr Glu Leu Arg Tyr Phe Ala Asn Asn Asn Gly Leu Val Tyr Gly Lys 
    130                 135                 140                 


Asp Ile Tyr Phe Asp Asp Asn Pro Met Asn Leu Ser Tyr Ile Leu Asn 
145                 150                 155                 160 


Phe Asn Arg Glu Leu Glu Gly Ile Met Ser Arg Arg Phe Asp Gly Ala 
                165                 170                 175     


Phe Pro Ser Thr Val Asn Pro Ile Leu Ile Trp Glu Ile Lys Glu Tyr 
            180                 185                 190         


Tyr Tyr Thr Thr Thr Phe Gly Ser Arg Ile Ala Asp Gly Val Tyr Glu 
        195                 200                 205             


Thr Gln Leu Asp Gly Tyr Glu Ile Lys Thr Ile Arg Glu Glu Thr Asn 
    210                 215                 220                 


Lys Asn Ile Gln His Ile Tyr Phe Ile Asp Asp Tyr Asn Thr Trp Trp 
225                 230                 235                 240 


Asn Met Gly Lys Ser Tyr Leu Cys Arg Ile Ile Asp Met Leu His Met 
                245                 250                 255     


Gly Leu Val Asp Glu Val Ile Met Gly Lys Glu Val Phe Glu Arg Trp 
            260                 265                 270         


Pro Gln Ile Leu Arg Ala Val Leu Asn Gln Tyr Tyr Lys 
        275                 280                 285 


<210>  13
<211>  223
<212>  PRT
<213>  Bacillus globigii

<400>  13

Met Lys Ile Asp Ile Thr Asp Tyr Asn His Ala Asp Glu Ile Leu Asn 
1               5                   10                  15      


Pro Gln Leu Trp Lys Glu Ile Glu Glu Thr Leu Leu Lys Met Pro Leu 
            20                  25                  30          


His Val Lys Ala Ser Asp Gln Ala Ser Lys Val Gly Ser Leu Ile Phe 
        35                  40                  45              


Asp Pro Val Gly Thr Asn Gln Tyr Ile Lys Asp Glu Leu Val Pro Lys 
    50                  55                  60                  


His Trp Lys Asn Asn Ile Pro Ile Pro Lys Arg Phe Asp Phe Leu Gly 
65                  70                  75                  80  


Thr Asp Ile Asp Phe Gly Lys Arg Asp Thr Leu Val Glu Val Gln Phe 
                85                  90                  95      


Ser Asn Tyr Pro Phe Leu Leu Asn Asn Thr Val Arg Ser Glu Leu Phe 
            100                 105                 110         


His Lys Ser Asn Met Asp Ile Asp Glu Glu Gly Met Lys Val Ala Ile 
        115                 120                 125             


Ile Ile Thr Lys Gly His Met Phe Pro Ala Ser Asn Ser Ser Leu Tyr 
    130                 135                 140                 


Tyr Glu Gln Ala Gln Asn Gln Leu Asn Ser Leu Ala Glu Tyr Asn Val 
145                 150                 155                 160 


Phe Asp Val Pro Ile Arg Leu Val Gly Leu Ile Glu Asp Phe Glu Thr 
                165                 170                 175     


Asp Ile Asp Ile Val Ser Thr Thr Tyr Ala Asp Lys Arg Tyr Ser Arg 
            180                 185                 190         


Thr Ile Thr Lys Arg Asp Thr Val Lys Gly Lys Val Ile Asp Thr Asn 
        195                 200                 205             


Thr Pro Asn Thr Arg Arg Arg Lys Arg Gly Thr Ile Val Thr Tyr 
    210                 215                 220             


<210>  14
<211>  288
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  14

Met Ile Lys Asn Phe Arg Asp Tyr Gln Arg Val Ala Ala Lys Tyr Ile 
1               5                   10                  15      


Thr Phe Ile Glu Ser Glu Phe Tyr Pro Asp Tyr Leu Asp Asn Ala Arg 
            20                  25                  30          


Phe Leu Tyr Gly Glu Val Leu Asn Lys Phe Tyr Glu Leu Val Asn Ser 
        35                  40                  45              


Ser Ser Ser Ser Ile Glu Leu Leu Glu Asn Ile Ser Lys Thr Lys Asp 
    50                  55                  60                  


Pro Val Arg Thr Gln Leu Leu Arg Ile Phe Arg Lys Tyr Val Ser Pro 
65                  70                  75                  80  


Asp Thr Ser Val Glu Met Leu Lys Arg Lys Gln Arg Ile Pro Asp Ile 
                85                  90                  95      


Ile Lys Glu Phe Gly Thr Arg Phe Arg Asp Ile Lys Ile Val Arg Gln 
            100                 105                 110         


Lys Ile Ala Thr Arg Asn His Pro Asp Glu Thr Ile Met Ala Leu Leu 
        115                 120                 125             


Tyr Glu Tyr Lys Asp Arg Gly Lys Lys Gly Tyr Glu Leu Thr Asp Ala 
    130                 135                 140                 


Phe Phe Thr Trp Phe Glu Gln Lys Phe Pro Asn Tyr Glu Ile Ile Gly 
145                 150                 155                 160 


Pro Arg Gly Ala Gly Lys Asp Ile Leu Leu Asn Glu Val Leu Pro Gly 
                165                 170                 175     


Phe Pro Ser Lys Ile Pro Ala Asp Phe Leu Ile Tyr Arg Arg Ser Asp 
            180                 185                 190         


Lys Thr Pro Ile Val Val Gly Phe Ala Arg Tyr Asp Ser Asp Arg Gly 
        195                 200                 205             


Gly Ala Gln Glu Asp Asp Arg Thr Gly Gly Asn Arg Asp Lys Ile Thr 
    210                 215                 220                 


Glu Ile Lys Lys Tyr Ala Ala Glu His Asn Ile Pro Leu Lys Ile Leu 
225                 230                 235                 240 


Phe Leu Asn Asp Gly Pro Gly Leu Leu Leu Gly Ser Met Trp Asn Asp 
                245                 250                 255     


Tyr Ser Ala Leu Glu Asp Tyr Gly Glu Gly Cys Val Met Val Cys Thr 
            260                 265                 270         


Leu Lys Met Leu Glu Glu Arg Phe Thr Ile Asp Trp Leu Glu Asn Leu 
        275                 280                 285             


<210>  15
<211>  353
<212>  PRT
<213>  Bacillus aneurinolyticus

<400>  15

Met Ala Gln Leu Lys Tyr Asn Lys Asp Ile Asp Glu Leu Glu Arg Asn 
1               5                   10                  15      


Ala Ala Lys Trp Trp Pro Asp Phe Leu Ala Lys Lys Glu Ser Ser Thr 
            20                  25                  30          


Ser Ile Ile Pro Lys Leu Val Glu Ser Gln Asp Ala Phe Ile Ser Leu 
        35                  40                  45              


Leu Asn Leu Ser Lys Asn Asn Pro Phe Asp Ile Phe Gln Leu Ile Asp 
    50                  55                  60                  


Ala Ser Lys Phe Pro Pro Asn Leu Phe Leu Lys His Leu Val Val Leu 
65                  70                  75                  80  


Thr Asp Phe Gly Gly Glu Pro Leu Asn Arg Leu Asn Gln Asn Phe Asp 
                85                  90                  95      


Ser Leu Phe Pro Met Ile Pro Tyr Gly Asn Pro Leu His Asn Lys Ser 
            100                 105                 110         


Val Arg Lys Phe Glu Phe Phe Trp Asn Glu Lys Lys Tyr Glu Tyr Val 
        115                 120                 125             


Phe Gln Glu Leu Pro Val Thr Ser Leu Thr Asn Ser Lys Leu Lys Ile 
    130                 135                 140                 


Asp Gly Ala Ser Ile Ser Lys Thr Val Pro Leu Ser Asp Leu Tyr Lys 
145                 150                 155                 160 


Asp Val Ile Val Leu Leu Met Phe Gly Ala Asn Ala Val Asn Ser Glu 
                165                 170                 175     


Val Ser Glu Val Leu Arg Lys Cys Glu Val Gly Asn Leu Ile Gly Lys 
            180                 185                 190         


Thr Asp Glu Leu Lys Lys Phe Ile Lys Glu Arg Tyr Ile Phe Val Ser 
        195                 200                 205             


Arg Ile Thr Gly Gly Ala Glu Ala Asn Thr Leu Gly Gln Val Ala Gln 
    210                 215                 220                 


Thr His Val Ile Asp Phe Leu Arg Thr Arg Leu Gly Lys Gly Tyr Asp 
225                 230                 235                 240 


Ile Lys Ser Asn Gly His Ile Glu Gly Val Thr His Asn Asp Gly Gln 
                245                 250                 255     


Thr Leu Thr Thr Phe Asp Val Val Ile Lys Lys Gly Ser Lys Ser Val 
            260                 265                 270         


Ala Ile Glu Ile Ser Phe Gln Val Thr Thr Asn Ser Thr Ile Glu Arg 
        275                 280                 285             


Lys Ala Gly Gln Ala Lys Ala Arg Tyr Asp Met Val Ser Asp Thr Gly 
    290                 295                 300                 


Asn Tyr Ile Ala Tyr Ile Ile Asp Gly Ala Gly Asn Phe Gln Arg Lys 
305                 310                 315                 320 


Asn Ala Ile Thr Thr Ile Cys Asn Asn Ser His Cys Thr Val Ala Tyr 
                325                 330                 335     


Thr Glu Glu Glu Leu Asn Val Leu Leu Lys Phe Ile Leu Glu Lys Leu 
            340                 345                 350         


Glu 
    


<210>  16
<211>  272
<212>  PRT
<213>  Pyrococcus species

<400>  16

Met Val Arg Asn Leu Val Ile Asp Ile Thr Lys Lys Pro Thr Gln Asn 
1               5                   10                  15      


Ile Pro Pro Thr Asn Glu Ile Ile Glu Glu Ala Ile Thr Glu Leu Asn 
            20                  25                  30          


Val Asp Glu Leu Leu Asp Arg Leu Phe Glu Lys Asp Glu Ser Gly Glu 
        35                  40                  45              


Val Ile Thr Pro Ser Arg Ile Ala Lys Met Leu Glu Glu Lys Ala Phe 
    50                  55                  60                  


Glu Ile Tyr Lys Glu Tyr Glu Lys Gln Val Arg Glu Ala Tyr Leu Ser 
65                  70                  75                  80  


Ala Gly Tyr Ser Arg Glu Lys Leu Glu Gln Ser Phe Gln Gln Ala Arg 
                85                  90                  95      


Phe Ser Arg Gly Gly Lys Ala Phe Glu Ile Ile Phe Thr Lys Leu Leu 
            100                 105                 110         


Asn Lys Phe Gly Ile Arg Tyr Glu His Asp Arg Val Ile Lys Ile Tyr 
        115                 120                 125             


Asp Tyr Ile Thr Glu Gly Glu Lys Pro Asp Phe Ile Ile Pro Ser Val 
    130                 135                 140                 


Arg Ala Phe Leu Asn Asp Pro Ser Ser Ala Ile Leu Ile Thr Val Lys 
145                 150                 155                 160 


Arg Lys Val Arg Glu Arg Trp Arg Glu Ala Val Gly Glu Ala Gln Ile 
                165                 170                 175     


Leu Arg Asn Lys Phe Gly Asp Glu Ile Asn Phe Trp Phe Val Gly Phe 
            180                 185                 190         


Asp Glu Glu Phe Thr Ile Tyr Ser Ala Ile Ala Met Leu Asp Asn Gly 
        195                 200                 205             


Ile Asp Arg Val Tyr Val Ile Asp Gly Arg Tyr Asp Ser Leu Ile Glu 
    210                 215                 220                 


Glu Ile Lys Arg Ile Ser Asp Pro Asn Phe Asn Glu Asp Lys Tyr Ile 
225                 230                 235                 240 


Gln Lys Ile Arg Arg Phe Ser Asp Ile Phe Asp Asp Ile Ile Gln Phe 
                245                 250                 255     


Leu Asn Lys His Gly Asn Lys Lys Arg Gly Lys Gln Leu Thr Leu Val 
            260                 265                 270         


<210>  17
<211>  188
<212>  PRT
<213>  Sphaerotilus natans

<400>  17

Met Ser Ile Asp Pro Asn Lys Leu Asn Ser Ala Leu Tyr Ala Ile Leu 
1               5                   10                  15      


Gly Gly Tyr Arg Gly Lys Phe Ser Asn Lys Val Tyr Asn Gly Glu Asn 
            20                  25                  30          


Asp Glu Phe Asp Ile Leu Met Glu Ile Phe Gly Ile Ser Pro Leu Leu 
        35                  40                  45              


Lys Arg Glu Ser Arg Gln Tyr Trp Gly Arg Glu Leu Gly Met Cys Trp 
    50                  55                  60                  


Pro Arg Leu Val Val Glu Ile Cys Lys Gln Thr Arg Asn Asp Phe Gly 
65                  70                  75                  80  


Ser Ala Leu Gln Ile Asp Gly Gly Glu Pro Cys Asp Leu Ile Val Gly 
                85                  90                  95      


Gly Leu Ala Ile Glu Thr Lys Tyr Arg Ile Gly Ser Gly Asp Ala Gly 
            100                 105                 110         


Thr Leu Lys Lys Phe Gln Ala Tyr Gly Ser Leu Leu Ser Ser Met Gly 
        115                 120                 125             


Tyr Glu Pro Val Leu Leu Ile Val Arg Glu Asp Asn Leu Gly Ala Ala 
    130                 135                 140                 


Ile Thr Ala Cys His Ala Gly Gly Trp Thr Val Ile Thr Gly Gln Arg 
145                 150                 155                 160 


Thr Phe Asp Tyr Leu Arg Asp Leu Thr Gly Ile Asn Ile Lys Glu Leu 
                165                 170                 175     


Leu Leu Gln Arg Ala Gly Lys Phe Pro Val Val Arg 
            180                 185             


<210>  18
<211>  465
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  18

Met Ala Arg Glu Glu Arg Glu Trp His Pro Lys Phe Ile Glu Tyr Met 
1               5                   10                  15      


Asp Phe Ile Ile Gln His Pro Asn Tyr Lys Gly Leu Pro Ile Thr Lys 
            20                  25                  30          


Lys Ser Asp Gly Ser Trp Ser Trp Phe Gly Thr Lys Lys Thr Gln Ile 
        35                  40                  45              


Gly Lys Ala Arg Ile Ala Trp Cys Glu Asn Lys Ala Lys Glu Leu Gly 
    50                  55                  60                  


Phe Pro Ile Glu Pro Gly Val Tyr Ala Asn Val Met Arg Glu Ile His 
65                  70                  75                  80  


Pro Thr Lys Trp Lys Val Cys Gln Thr Cys Gly His Ser Met Ser Ile 
                85                  90                  95      


Tyr Tyr His Tyr Pro Ser Ala Asn Phe Leu Lys Ala Leu Lys Lys Glu 
            100                 105                 110         


Phe Gly Val Glu Tyr Thr Glu Val Asp His Ile Ala Asp Ile Trp Asp 
        115                 120                 125             


Asp Leu Leu Ser Arg Gly Phe Ser Asn Asn Lys Ile Ala Ser Phe Leu 
    130                 135                 140                 


Ile Lys Lys Gly Glu Leu Asp Leu Asn Ala Lys Thr Ser Ser Lys Asp 
145                 150                 155                 160 


Glu Val Ile Tyr Glu Leu Glu Ser Val Cys Arg Asn Lys Gly Lys Lys 
                165                 170                 175     


Ile Leu Ser Pro Gly Ala Met Ser Asn Phe Pro Asp Arg Phe Asp Gly 
            180                 185                 190         


Phe His Thr Tyr Asn Arg Cys Cys Arg Ala Ser Gln Asp Lys Gly Arg 
        195                 200                 205             


Ser Lys Glu Asn Leu Lys Ser Tyr Thr Lys Asp Arg Arg Ala Tyr Glu 
    210                 215                 220                 


Tyr Trp Ser Asp Gly Asn Ile His Ala Ala Asn Gln Phe Met Gly Ser 
225                 230                 235                 240 


Pro Phe Phe Asn Asn Ile Ser Ala Asp His Ile Gly Pro Ile Ser Leu 
                245                 250                 255     


Gly Phe Val His Asp Pro Arg Tyr Leu Gln Pro Met Ser Gly Gly Asp 
            260                 265                 270         


Asn Ser Ser Lys Arg Asp Arg Leu Gln Leu Asp Asp Ile Glu Lys Ile 
        275                 280                 285             


Ile Glu Thr Glu Lys Arg Thr Asn Val Tyr Pro Met Ser Trp Tyr Ser 
    290                 295                 300                 


Lys Leu Ile Trp Glu Tyr Ile Lys Lys Asn Tyr Ser Thr His Lys Ser 
305                 310                 315                 320 


Leu Ile Ser Gly Val Tyr Arg Asp Ala Leu Lys Gln Asn Met Ser Asn 
                325                 330                 335     


Phe Met Tyr Ile Leu Trp Tyr Ile Leu Glu His Cys Asn Gln Asp Gly 
            340                 345                 350         


Glu His Phe Leu Glu Glu Ala Leu Leu Lys Pro Asn Tyr Asp Tyr Phe 
        355                 360                 365             


Gln Tyr Ser Tyr Thr Phe Asn Glu Leu Gly Glu Ile Val Ser Ile Asn 
    370                 375                 380                 


Pro Arg His Phe Thr Asp Arg Asn Gln Tyr Glu Thr Glu Arg Tyr Lys 
385                 390                 395                 400 


Arg Ile Ala Phe Glu Ser Val Tyr Asp Tyr Asn Glu Lys Glu Asn Arg 
                405                 410                 415     


Asn Ile Lys Ala Asn Leu Ile Asp Asn Glu Gln Arg Met Leu Asn Lys 
            420                 425                 430         


Leu Cys Gln Glu Ile Ser Ser Gly Val Pro Val Glu Gln Cys Lys Lys 
        435                 440                 445             


Leu Leu Ile Glu Leu Met Glu Val Ile Gln Lys Arg Ile Ile Ser Thr 
    450                 455                 460                 


Leu 
465 


<210>  19
<211>  383
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  19

Met Ala Ile Thr Leu Cys Asp Ile Asn Gly Cys Arg Leu Glu Arg Gly 
1               5                   10                  15      


His Thr Gly Lys His Asn Lys Phe Pro Glu Phe Val Trp Thr Ser Gln 
            20                  25                  30          


Phe Asn Lys Lys Asp Ile Asp Lys Val Asn Lys Ala Gly Tyr Ala Thr 
        35                  40                  45              


Pro Arg Gly Gly Asp Lys Gly Ala Tyr Gln Asn His Val Tyr Arg Asn 
    50                  55                  60                  


Asn Lys Val Ile Ile Pro Phe Glu Arg Leu Glu Asn Val Asn Leu Asn 
65                  70                  75                  80  


Asn Tyr Gln Asp Gly Tyr Val Ile Arg Leu Phe Pro Asn Gln Tyr Phe 
                85                  90                  95      


Glu Ser Ala Gly Val Val Lys Pro Glu Phe Leu Gln Pro Asn Ser Phe 
            100                 105                 110         


Val Lys Val Gly Asp Asn Ala Phe Ile Leu Tyr Arg Thr His Ser Ser 
        115                 120                 125             


Phe Glu Glu Leu Pro Pro Leu Pro Asp Trp Glu Val Arg His Leu Lys 
    130                 135                 140                 


Lys Asn Gly Asn Ile Val Thr Arg Arg Ser Lys Asp Val Ile Asp Ala 
145                 150                 155                 160 


Gly His Tyr Val Leu Arg Leu Ser Ser Ile Ser Asn Lys Lys Glu Arg 
                165                 170                 175     


Lys Glu Gly Pro Pro Gln Gly Ile Phe Ala Pro Glu Tyr Ala Asn Ala 
            180                 185                 190         


Glu Thr Asn Tyr Leu Ser Lys Ala Phe Leu Ala Trp Leu Ile Ile Lys 
        195                 200                 205             


Thr Gln Asn Ser Pro Tyr Asn Glu Glu Gln Phe Gln His Leu Arg Ala 
    210                 215                 220                 


Ile Leu Ile Ser His Asn Leu Ile Asn Ile Ser Gln Leu Glu Glu Lys 
225                 230                 235                 240 


Ala Ile Leu Lys Asn Gly Ile Thr Cys Cys Pro Leu Cys Glu Gln Ile 
                245                 250                 255     


Ile Phe Tyr Glu Gln Leu His Glu Met Val Ser Phe Glu Gly Ala Ser 
            260                 265                 270         


Gly Leu Ala Asn Ser Gln Glu Gln Val Glu Gly Ala Thr Arg Ser Thr 
        275                 280                 285             


Ser Val Asn Leu Phe His Met Val Pro Leu Val Tyr Glu Thr Leu Glu 
    290                 295                 300                 


His Lys Pro Asp Gln Ile Ala Trp Gly His Ala Ile Cys Asn Thr Arg 
305                 310                 315                 320 


Leu Gly Gln Arg Glu Cys Leu Pro Leu Ser Arg Leu Lys Gln Glu Gly 
                325                 330                 335     


Thr Pro Val Gly Leu Leu Asp Glu Asp Ser Asn Leu Glu Val Leu Gly 
            340                 345                 350         


Trp Ile Ser Lys Asp Lys Gln Phe Ile Arg Thr Glu Asn Gly Glu Val 
        355                 360                 365             


Trp Ile Lys Ile Thr Asp Ile Glu Phe Asn Asp Asp Phe Glu Glu 
    370                 375                 380             


<210>  20
<211>  269
<212>  PRT
<213>  Streptomyces fimbriatus

<400>  20

Met His Gln Asp Tyr Arg Glu Leu Ser Leu Asp Glu Leu Glu Ser Val 
1               5                   10                  15      


Glu Lys Gln Thr Leu Arg Thr Ile Val Gln Ala Leu Gln Gln Tyr Ser 
            20                  25                  30          


Lys Glu Ala Lys Ser Ile Phe Glu Thr Thr Ala Ala Asp Ser Ser Gly 
        35                  40                  45              


Glu Val Ile Val Leu Ala Glu Asp Ile Thr Gln Tyr Ala Leu Glu Val 
    50                  55                  60                  


Ala Glu Thr Tyr Pro Ile Asn Arg Arg Phe Ala Gly Phe Ile Asp Tyr 
65                  70                  75                  80  


Lys Arg Val Arg Trp Leu Pro Ser Pro His Gly Leu Leu Pro Gln Val 
                85                  90                  95      


Leu Leu Val Asp Ala Lys Ala Ser Thr Glu Lys Asn Arg Asp Thr Leu 
            100                 105                 110         


Gln Arg Ser Gln Leu Pro Met Asp Ala Glu Phe Arg Asn Thr Ser Ser 
        115                 120                 125             


Gly Glu Val Val Thr Met Glu Ala Gly Val Ile Pro His Leu Met Leu 
    130                 135                 140                 


Gln Ser Ala Asn Asp Gly Val Leu Pro Ala Val Thr Thr Ser Ile Phe 
145                 150                 155                 160 


Val His Phe Tyr Tyr Arg Glu Leu Lys Asp Val Glu Gly Arg Tyr Arg 
                165                 170                 175     


Glu Leu Lys Ser Ile Tyr Val Leu Ser Leu Pro His Ala Arg Leu Lys 
            180                 185                 190         


Gln Arg Tyr Asn Pro Asp Pro Asp Thr Ser Phe Phe Gly Ala Gly Lys 
        195                 200                 205             


His Ser Pro Ala Arg Gly Glu Val Ala Arg Ile Arg Val Tyr Phe Asp 
    210                 215                 220                 


Arg Leu Lys Glu Ala Cys Pro Trp Arg Leu Gln Glu Leu His Tyr Ser 
225                 230                 235                 240 


Ala Asp Ser Glu Tyr Thr Gln Pro Arg Trp Arg Asp Leu Asn Asp Ala 
                245                 250                 255     


Gly His Glu Val Thr Lys Glu Phe Leu Phe Leu Glu Arg 
            260                 265                 


<210>  21
<211>  231
<212>  PRT
<213>  Pseudomonas mendocina

<400>  21

Met Thr Thr Asn Ser Pro Ser Asp Val Gly Met Ile Asp Glu Cys Leu 
1               5                   10                  15      


Ser Ile Val Arg Thr Ser Leu Ala Arg Cys Phe Gln Gln Gln Ala Pro 
            20                  25                  30          


Ser Ile Gln Ala Ser Trp Pro Leu Ser Gly Arg Ala Val Ser Glu Ile 
        35                  40                  45              


Gly Gly Arg Leu Val Glu Ser Phe Val Leu Ala Arg Leu Pro His Glu 
    50                  55                  60                  


Leu Ser Thr Thr Pro Phe Asp Gly Gln Ile Leu Cys Glu Ile Pro Glu 
65                  70                  75                  80  


Ser Gly Arg Ala Met Glu Asp Ile Ala Val Thr Phe Ile Gly Pro His 
                85                  90                  95      


Gly Arg Ala Arg Leu Leu Ile Asp Val Lys Gly His Asn Glu Tyr Arg 
            100                 105                 110         


Thr Gly Ser Arg Pro Asn Leu Ala Ser Ile Arg Lys Cys Leu Glu Leu 
        115                 120                 125             


Tyr Arg Ser Ser Ser His Thr Val Asp Glu Leu Val Val Phe Phe Cys 
    130                 135                 140                 


Arg Tyr Arg Pro Ser Val His Pro Asp His His Ala Gln Ala Val Glu 
145                 150                 155                 160 


Tyr His Val Leu Pro Glu Ser Phe Asn Glu Gln Gly Leu Phe Leu Leu 
                165                 170                 175     


Arg Ala Leu Ser Glu Ser Asn Leu Asp Pro Ala Asn Ile Gly Ser Gly 
            180                 185                 190         


Gly Gln Leu Leu Leu Ala Arg Glu Asn Asn Ile Arg Leu Val Asn Arg 
        195                 200                 205             


Ser Arg Ser Glu Phe Val Gln Leu Leu Glu Gly Leu Gln Ser Arg Leu 
    210                 215                 220                 


Gln Arg Gly Arg Ser Thr Val 
225                 230     


<210>  22
<211>  247
<212>  PRT
<213>  Serratia marcescens

<400>  22

Met Ser Arg Asp Asp Gln Leu Phe Thr Leu Trp Gly Lys Leu Asn Asp 
1               5                   10                  15      


Arg Gln Lys Asp Asn Phe Leu Lys Trp Met Lys Ala Phe Asp Val Glu 
            20                  25                  30          


Lys Thr Tyr Gln Lys Thr Ser Gly Asp Ile Phe Asn Asp Asp Phe Phe 
        35                  40                  45              


Asp Ile Phe Gly Asp Arg Leu Ile Thr His His Phe Ser Ser Thr Gln 
    50                  55                  60                  


Ala Leu Thr Lys Thr Leu Phe Glu His Ala Phe Asn Asp Ser Leu Asn 
65                  70                  75                  80  


Glu Ser Gly Val Ile Ser Ser Leu Ala Glu Ser Arg Thr Asn Pro Gly 
                85                  90                  95      


His Asp Ile Thr Ile Asp Ser Ile Lys Val Ala Leu Lys Thr Glu Ala 
            100                 105                 110         


Ala Lys Asn Ile Ser Lys Ser Tyr Ile His Val Ser Lys Trp Met Glu 
        115                 120                 125             


Leu Gly Lys Gly Glu Trp Ile Leu Glu Leu Leu Leu Glu Arg Phe Leu 
    130                 135                 140                 


Glu His Leu Glu Asn Tyr Glu Arg Ile Phe Thr Leu Arg Tyr Phe Lys 
145                 150                 155                 160 


Ile Ser Glu Tyr Lys Phe Ser Tyr Gln Leu Val Glu Ile Pro Lys Ser 
                165                 170                 175     


Leu Leu Leu Glu Ala Lys Asn Ala Lys Leu Glu Ile Met Ser Gly Ser 
            180                 185                 190         


Lys Gln Ser Pro Lys Pro Gly Tyr Gly Tyr Val Leu Asp Glu Asn Glu 
        195                 200                 205             


Asn Lys Lys Phe Ser Leu Tyr Phe Asp Gly Gly Ala Glu Arg Lys Leu 
    210                 215                 220                 


Gln Ile Lys His Leu Asn Leu Glu His Cys Ile Val His Gly Val Trp 
225                 230                 235                 240 


Asp Phe Ile Leu Pro Pro Pro 
                245         


<210>  23
<211>  345
<212>  PRT
<213>  Acetobacter aceti

<400>  23

Met Asn Pro Asp Glu Val Phe Ser Asp Phe Gln Arg Gly Phe Phe Gly 
1               5                   10                  15      


Arg Lys Phe Thr Ala Gly Leu Leu Val Ser Phe Ile Asp Leu Met Ser 
            20                  25                  30          


Glu Leu Glu Thr Pro Lys Leu Gly Ile Ala Asp Phe Asp Gly Phe Leu 
        35                  40                  45              


Lys Leu Phe Pro Arg Gln Leu Lys Thr Ser Ala Gly Lys Arg Ala Asn 
    50                  55                  60                  


Thr Leu Ile Val Glu Lys Glu Asp Gly Lys Thr Ile Ser Leu Arg Lys 
65                  70                  75                  80  


Phe Tyr Asn Ser Ile Glu Lys Phe Tyr Arg Ala Glu His Lys Arg Phe 
                85                  90                  95      


Asp Tyr Pro Ser Ala Ala Pro His Ala Thr Gln Ala Trp Ala Asp Tyr 
            100                 105                 110         


Lys Thr Trp Leu Asp Ala Leu Val Thr Phe Ser Glu Glu Gln Leu Gly 
        115                 120                 125             


Glu Leu Arg Gly Arg Val Asn Gln Phe Val Leu Asp Thr Leu Lys Ser 
    130                 135                 140                 


Gln Glu Phe Asp Pro Thr Ser Val Lys Val Glu Pro Pro Leu Phe Arg 
145                 150                 155                 160 


Ile Leu Leu Glu Lys Phe Glu Met Thr Ala Gln Lys Gly Glu Pro Thr 
                165                 170                 175     


Gly Ala Ser Phe Gln Gly Ile Val Phe Gly Phe Leu Arg Ala Asp Asn 
            180                 185                 190         


Pro His Leu Gln Ile Glu Ile Asp Lys Val Arg Thr Gly Ser Lys Arg 
        195                 200                 205             


Leu Gln Arg Ile Gly Asp Val Asp Gly Trp Glu Gly Glu Arg Leu Ala 
    210                 215                 220                 


Ile Ser Ala Glu Val Lys Gln Tyr Glu Ile Asn Thr Glu Ser Ile Asp 
225                 230                 235                 240 


Asp Leu Ala Asp Phe Ala Asn Arg Thr Gly Gln Arg Gly Ala Leu Gly 
                245                 250                 255     


Val Ile Ala Ala Leu Ser Phe Ser Glu Glu Ala Lys Pro Leu Leu Glu 
            260                 265                 270         


Asn Met Gly Leu Ile Ala Leu Asp Lys Glu Gly Met Leu Lys Ile Val 
        275                 280                 285             


Glu Leu Trp Asp Pro Val Lys Gln Arg Thr Ala Val Ser Ser Phe Ile 
    290                 295                 300                 


Tyr Tyr Ala Thr His Val Glu Lys Asn Ser Ser Leu Ser Ala Arg Leu 
305                 310                 315                 320 


Asn Ile Phe Leu Glu Ala Ser Ala Ser Glu Trp Ala Glu Gln Arg Gln 
                325                 330                 335     


Ala Ala Ile Leu Pro Gln Ser Glu Ser 
            340                 345 


<210>  24
<211>  237
<212>  PRT
<213>  Arthrobacter protophormiae

<400>  24

Met Ala Gln Lys Ala Arg Leu Arg Gln Asn Arg Tyr Gly Thr Val Ile 
1               5                   10                  15      


Asn Thr Thr Ser Ser Lys Gln Glu Leu Gln Leu Gly Asp Ala Leu Val 
            20                  25                  30          


Asp Ala Thr Glu Arg Leu Thr Ala Lys Phe Gly Ile Ala Phe Thr His 
        35                  40                  45              


Glu Lys Lys Val Met Leu Ala Asp Ile Val Thr Ser Leu Arg Arg Ser 
    50                  55                  60                  


Phe Pro Thr Val Ser Phe Asp Asp Pro Leu Pro Asn Thr Tyr Met Ser 
65                  70                  75                  80  


Pro Asp Gly Gly Ile Leu Ser Ile Met Ala Ala Asp Gly Glu Arg Thr 
                85                  90                  95      


Phe Pro Val Leu Ile Thr Glu Val Lys Asn Gln Gly Thr Asn Asp Leu 
            100                 105                 110         


Arg Ala Gln Glu Gly Leu Lys Lys Gln Ala Met Gly Asn Ala Ile Glu 
        115                 120                 125             


Arg Leu Gly Lys Asn Val Ile Gly Phe Arg Ala Met Met Leu Glu Asp 
    130                 135                 140                 


Gly Ile Ile Pro Phe Val Cys Phe Gly Tyr Gly Trp Asp Phe His Glu 
145                 150                 155                 160 


Gly Ser Ser Ile Leu Asp Arg Val Lys Thr Ile Ala Met Phe Gly Glu 
                165                 170                 175     


Leu Asn Gln Val Asn Val Ile Pro Glu Gly Glu Glu Gly Leu Phe Asn 
            180                 185                 190         


Arg Gly Ser Phe Phe Phe Arg Met Glu Pro Trp Ser Leu Glu Glu Met 
        195                 200                 205             


Ser Asp Val Met Phe Asp Val Gly Ser Arg Ala Ile His Tyr Tyr Phe 
    210                 215                 220                 


Ala Lys Phe Gly Asp Ser Ala Phe Lys Met Ile Gly Ser 
225                 230                 235         


<210>  25
<211>  530
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  25

Met Ala Lys Tyr Gly Arg Gly Lys Phe Leu Pro His Gln Asn Tyr Ile 
1               5                   10                  15      


Asp Tyr Met His Phe Ile Val Asn His Lys Asn Tyr Ser Gly Met Pro 
            20                  25                  30          


Asn Ala Ile Gly Glu Asp Gly Arg Ile Asn Trp Gln Val Ser Ser Gly 
        35                  40                  45              


Lys Thr Thr Ser Phe Tyr Glu Tyr Tyr Gln Ala Arg Phe Glu Trp Trp 
    50                  55                  60                  


Glu Lys Lys Ala Asp Glu Leu Asn Leu Pro Gly Thr Gly Asn Ser Asn 
65                  70                  75                  80  


Lys Arg Phe Ser Leu Ala Ala Arg Leu Ile His Pro Thr Gly Gln Arg 
                85                  90                  95      


Pro Cys Arg Leu Cys Gly Lys Tyr Gln Tyr Val Gly Tyr Met Tyr Val 
            100                 105                 110         


Ser His Asn Leu Tyr Lys Arg Trp Ser Lys Ile Thr Gly Arg Glu Asp 
        115                 120                 125             


Leu Phe Phe Lys Lys Gln Asn Ile Ile Glu Ala Ala Asn Ile Phe Lys 
    130                 135                 140                 


Ser Ile Met Gly Glu Gln Ala Leu Ile Asn Glu Leu Thr Thr Ile Phe 
145                 150                 155                 160 


Pro Glu Arg Lys Asp Tyr Phe Asn Arg Leu Pro Asn Ile Glu Asp Phe 
                165                 170                 175     


Phe Val Ser Ser Ser His Ile Lys Asn Asn Gly Asn Tyr Ile Ser Pro 
            180                 185                 190         


Gly Phe Met Ala Asn Pro Pro Asp Arg Leu Asp Gly Phe His Asp Tyr 
        195                 200                 205             


Gly Ile Cys Cys Arg Lys Glu Lys Asp Pro Gly Arg His Asp Asp Asn 
    210                 215                 220                 


Met Arg Leu Tyr Asn His Asp Arg Arg Ala Phe Met Trp Trp Ser Glu 
225                 230                 235                 240 


Gly Asp Trp Ala Leu Ala Asp Ala Leu Tyr Asn Lys Ala Gly Ala Gly 
                245                 250                 255     


Lys Cys Ala Asp Pro Asp Cys Gln Lys Glu Val Glu Lys Ile Ser Pro 
            260                 265                 270         


Asp His Val Gly Pro Ile Ser Cys Gly Phe Lys Gln Ile Pro Phe Phe 
        275                 280                 285             


Lys Pro Leu Cys Ala Ser Cys Asn Ser Ala Lys Asn Arg Arg Phe Ser 
    290                 295                 300                 


Tyr Gln Asp Val Lys Glu Leu Leu Lys Tyr Glu Asn Tyr Thr Gly Asp 
305                 310                 315                 320 


Ser Val Ala Ser Trp Gln Val Arg Ala Leu Trp Asp Asn Cys Lys His 
                325                 330                 335     


Leu Val Lys Asn Asp Asp Asp Ser Lys Leu Leu Ser Asn Leu Met Arg 
            340                 345                 350         


Ser Leu Gln Asp Tyr Tyr Leu Arg Ser Leu Tyr Lys Leu Phe Ser Asn 
        355                 360                 365             


Gly Phe Ala His Leu Leu Ser Tyr Phe Leu Thr Pro Glu Tyr Ala His 
    370                 375                 380                 


Tyr Lys Ile Thr Phe Glu Gly Leu Asn Thr Ser Thr Leu Glu Tyr Glu 
385                 390                 395                 400 


Arg Tyr Tyr Lys Thr Phe Lys Lys Thr Lys Ser Thr Ser Ser Leu Ala 
                405                 410                 415     


Ala Arg Ile Val Arg Ile Ala Phe Glu Glu Leu Glu Ile Tyr Asn Ser 
            420                 425                 430         


Lys Asp Ile Asn Glu Arg Lys Leu Ile Lys Phe Asp Thr Ser Ser Trp 
        435                 440                 445             


Glu Lys Asp Phe Glu Asn Ile Ile Ser Tyr Ala Thr Lys Asn Leu Ser 
    450                 455                 460                 


Leu Asp Glu Glu Ala Ser Lys Trp Asn Lys Val Leu Thr Asp Lys Asn 
465                 470                 475                 480 


Leu Ser Ser Thr Glu Lys Asp Lys Lys Ile Ser Ser Leu Leu Glu Asp 
                485                 490                 495     


Lys Asn Tyr Glu Val Tyr Lys Lys Gln Phe Tyr Ile Leu Lys Asp Leu 
            500                 505                 510         


Leu Val Glu His Phe Asn Lys Ile Gly Glu Gln Ile Ala Lys Asp Tyr 
        515                 520                 525             


Met Lys 
    530 


<210>  26
<211>  246
<212>  PRT
<213>  Bacillus megaterium

<400>  26

Met Leu Lys Ile Glu Asp Ile Val Glu Ile Arg Lys Ala Ile Gly Arg 
1               5                   10                  15      


Pro Gly Tyr Glu Ile Val Phe Ser Lys Asp Lys Val Ile Trp Leu Thr 
            20                  25                  30          


Lys Arg Arg Thr Ile Ile Ser Leu Leu Leu Leu Ile Lys Tyr Gly Ile 
        35                  40                  45              


Ser Ser Glu Ala Asp Leu Ala Arg Gly Ser Asn Arg Leu Leu Glu Val 
    50                  55                  60                  


Lys Gly Ile Leu Lys Gly Lys Tyr Asn Glu Thr Trp Ile Asn Asp His 
65                  70                  75                  80  


Tyr Ala Asp Ala Asn Lys Pro Phe Ser Glu Leu Trp Asn Glu Glu Gly 
                85                  90                  95      


Phe Thr Trp Ile His Pro Ala Gln Glu Lys Leu Asn Gly Asn Gln Gln 
            100                 105                 110         


Tyr Val Leu Lys Pro Glu Asp His Asp Lys Leu Phe Ile Leu Ile Lys 
        115                 120                 125             


Lys Ala Phe Arg Thr Ser Leu Ser Ile Lys Glu Gln Asp Glu Val Met 
    130                 135                 140                 


Lys Lys Gln Asn Gly Lys Cys Asn Leu Cys Gly Ser Ser Leu Leu Pro 
145                 150                 155                 160 


Lys Ser Lys Ile Gln Lys Asn Thr Tyr Ala Lys Asp Arg Val Arg Gly 
                165                 170                 175     


Val Phe Asp His Arg Ile Pro Val Glu Lys Gly Gly Asp Ser Thr Ile 
            180                 185                 190         


Asp Asn Tyr Gln Ala Leu Cys Phe Tyr Cys Asn Lys Ser Lys Trp Gln 
        195                 200                 205             


Ile Cys Asn Ile Cys His Leu Asp Asp Cys Asp Thr Asn Cys Val Leu 
    210                 215                 220                 


Ala Thr Pro Glu Asn Asn Asn Ile Ile Ser Pro Thr Lys Glu Asp Ile 
225                 230                 235                 240 


Ser Asp Arg Leu Asn Arg 
                245     


<210>  27
<211>  236
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  27

Met Met Asp Ile Lys Thr Phe Ile Lys Lys Leu Glu Glu Ile Lys Ala 
1               5                   10                  15      


Lys Gly Tyr Ile Arg Thr Leu Arg Arg Gly Asp Thr Gly Val Gly His 
            20                  25                  30          


Thr Leu Glu Gln Glu Leu Gly Leu Thr Glu Asn Asn Ile Ser Leu Pro 
        35                  40                  45              


Asp Leu Gly Val Ala Glu Leu Lys Ala Ala Arg Arg Asn Thr Ser Ser 
    50                  55                  60                  


Met Leu Thr Leu Phe Thr Lys Glu Pro Leu Ser Asp Lys Gly Arg Lys 
65                  70                  75                  80  


Arg Asp Arg Tyr Leu Leu Glu Thr Phe Ala Tyr Asp Ser Asp Lys Glu 
                85                  90                  95      


Asp Arg Ile Lys Glu Leu Tyr Thr Thr Ile Ser Ala Leu Asp Tyr Asn 
            100                 105                 110         


Ala Gln Gly Phe Lys Leu Glu Val Thr Asn Lys Glu Ile Arg Leu Ile 
        115                 120                 125             


His Lys Asp Ile Pro Leu Asp Val Tyr Trp Thr Ala Glu Leu Leu Gln 
    130                 135                 140                 


Lys Thr Phe Glu Asp Lys Leu Pro Ala Leu Val Tyr Val Tyr Ala Asp 
145                 150                 155                 160 


His Ile Gly Glu Asp Ala Asp Glu His Phe His Tyr Thr Glu Ala Arg 
                165                 170                 175     


Leu Leu Lys Gly Phe Asp Phe Lys Gly Phe Met Lys Ala Val Gln Asp 
            180                 185                 190         


Gly Tyr Ile Lys Val Asp Leu Arg Met His Met Lys Asn Asn Gly Arg 
        195                 200                 205             


Pro Arg Asn His Gly Thr Ala Phe Arg Ile Leu Arg Ser His Leu Pro 
    210                 215                 220                 


Ile Cys Phe Lys Glu Gln Gln Ile Leu Val Lys Pro 
225                 230                 235     


<210>  28
<211>  276
<212>  PRT
<213>  Micrococcus luteus

<400>  28

Met Ser Ala Pro Glu Val Asp Ser Ala Arg Asp Ala Arg Tyr Val Glu 
1               5                   10                  15      


Ile Leu Leu Ala Pro Leu Arg Lys Cys Gly Thr Tyr Leu Pro Lys Met 
            20                  25                  30          


Gly Gly Ser Gly Glu Val Asp Leu Ala Gly Phe Thr Ala Ala Tyr Gly 
        35                  40                  45              


Ala Asp Pro Leu Tyr His Trp Met Gly Leu Asp Ser Pro Leu Met Phe 
    50                  55                  60                  


Ala Ala His Lys Ala Ala Gly Gly Met Thr Ser Ile Tyr Arg Gln Leu 
65                  70                  75                  80  


Gly Ile Gly Ser Glu Arg Leu Phe Arg Gln Val Leu Arg Asp Glu Leu 
                85                  90                  95      


Asn Leu Thr Ala Asp Gln Val Lys Trp Ser Tyr Lys Met Leu Pro Glu 
            100                 105                 110         


Leu Asp Ala Glu His Ala Asn Glu Ser Val Lys Ala Arg Val Leu Ser 
        115                 120                 125             


Leu Asp Gly Arg Val Glu Leu Glu Asp Leu Glu Asp Gln Gln Ala Arg 
    130                 135                 140                 


Glu Arg Val Glu Ala Trp Ile Glu Val Gln Arg Arg Arg Leu Asn Ile 
145                 150                 155                 160 


Thr Ala Pro Leu Lys Gly Ala Val Phe Glu Val Arg Gln Gly Tyr Lys 
                165                 170                 175     


Ser Ala Asp Ser Lys Arg Gln Asn Ala Asp Leu Ala Asn Ala Ala Gln 
            180                 185                 190         


Ala Leu Gly His Gln Tyr Leu Pro Val Leu Val Ile Met Ser Thr Gln 
        195                 200                 205             


Ile Asn Glu Val Val His Ala Arg Tyr Thr Thr Gly Asn Trp Ser Val 
    210                 215                 220                 


Leu Met Gly Thr Val Gly Ala Ser Asp Pro Val Gly Ser Thr Tyr Asp 
225                 230                 235                 240 


Phe Leu Asp Gln Val Val Gly Tyr Asp Leu Ala Ala Phe Phe Glu Arg 
                245                 250                 255     


Asn Lys Ala Ala Leu Arg Ala Gly Thr Glu Gly Ile Leu Thr Asp Leu 
            260                 265                 270         


Leu Glu Ala Arg 
        275     


<210>  29
<211>  353
<212>  PRT
<213>  Bacillus aneurinolyticus

<400>  29

Met Ala Gln Leu Lys Tyr Asn Lys Asp Ile Asp Glu Leu Glu Arg Asn 
1               5                   10                  15      


Ala Ala Lys Trp Trp Pro Asp Phe Leu Ala Lys Lys Glu Ser Ser Thr 
            20                  25                  30          


Ser Ile Ile Pro Lys Leu Val Glu Ser Gln Asp Ala Phe Ile Ser Leu 
        35                  40                  45              


Leu Asn Leu Ser Lys Asn Asn Pro Phe Asp Ile Phe Gln Leu Ile Asp 
    50                  55                  60                  


Ala Ser Lys Phe Pro Pro Asn Leu Phe Leu Lys His Leu Val Val Leu 
65                  70                  75                  80  


Thr Asp Phe Gly Gly Glu Pro Leu Asn Arg Leu Asn Gln Asn Phe Asp 
                85                  90                  95      


Ser Leu Phe Pro Met Ile Pro Tyr Gly Asn Pro Leu His Asn Lys Ser 
            100                 105                 110         


Val Arg Lys Phe Glu Phe Phe Trp Asn Glu Lys Lys Tyr Glu Tyr Val 
        115                 120                 125             


Phe Gln Glu Leu Pro Val Thr Ser Leu Thr Asn Ser Lys Leu Lys Ile 
    130                 135                 140                 


Asp Gly Ala Ser Ile Ser Lys Thr Val Pro Leu Ser Asp Leu Tyr Lys 
145                 150                 155                 160 


Asp Val Ile Val Leu Leu Met Phe Gly Ala Asn Ala Val Asn Ser Glu 
                165                 170                 175     


Val Ser Glu Val Leu Arg Lys Cys Glu Val Gly Asn Leu Ile Gly Lys 
            180                 185                 190         


Thr Asp Glu Leu Lys Lys Phe Ile Lys Glu Arg Tyr Ile Phe Val Ser 
        195                 200                 205             


Arg Ile Thr Gly Gly Ala Glu Ala Asn Thr Leu Gly Gln Val Ala Gln 
    210                 215                 220                 


Thr His Val Ile Asp Phe Leu Arg Thr Arg Leu Gly Lys Gly Tyr Asp 
225                 230                 235                 240 


Ile Lys Ser Asn Gly His Ile Glu Gly Val Thr His Asn Asp Gly Gln 
                245                 250                 255     


Thr Leu Thr Thr Phe Asp Val Val Ile Lys Lys Gly Ser Lys Ser Val 
            260                 265                 270         


Ala Ile Glu Ile Ser Phe Gln Val Thr Thr Asn Ser Thr Ile Glu Arg 
        275                 280                 285             


Lys Ala Gly Gln Ala Lys Ala Arg Tyr Asp Met Val Ser Asp Thr Gly 
    290                 295                 300                 


Asn Tyr Ile Ala Tyr Ile Ile Asp Gly Ala Gly Asn Phe Gln Arg Lys 
305                 310                 315                 320 


Asn Ala Ile Thr Thr Ile Cys Asn Asn Ser His Cys Thr Val Ala Tyr 
                325                 330                 335     


Thr Glu Glu Glu Leu Asn Val Leu Leu Lys Phe Ile Leu Glu Lys Leu 
            340                 345                 350         


Glu 
    


<210>  30
<211>  285
<212>  PRT
<213>  Kluyvera ascorbata

<400>  30

Met Ser Val Ile Pro Cys Lys Lys Asp Leu Gln Leu Lys Lys Leu Ile 
1               5                   10                  15      


Glu Ser Tyr Ala Glu Ala Leu Lys Val Glu Ala His Lys Leu Gly Glu 
            20                  25                  30          


His Gly Leu Thr Glu Ala Glu Phe Tyr Asp Ser Gly Leu Phe Arg Gly 
        35                  40                  45              


Ala Ile Glu Arg Ile Arg Gly Gln Phe Ser Ala Thr Met Arg Glu Lys 
    50                  55                  60                  


Arg Asn Phe Val Lys His Val Leu Asn Tyr Met Gln Asp Asn Asp Tyr 
65                  70                  75                  80  


Ile Ala Asp Trp Glu Ser Ala Gly Glu Ser Asn Arg His Asp Tyr Met 
                85                  90                  95      


Val Thr Leu Asn Ser Gly Arg Lys Ala Ala Ile Glu Leu Lys Gly Cys 
            100                 105                 110         


Leu Asp Gly Asn Asn Thr Asn Ile Phe Asp Arg Pro Pro Gln Ala Glu 
        115                 120                 125             


Glu Phe Val Ile Trp Ser Val Cys Thr Asn Pro Gly Ala Asp Pro Gln 
    130                 135                 140                 


His Asn Val Trp Ser Gly Leu His Thr Arg Leu Ser Ala Glu Ile Ile 
145                 150                 155                 160 


Ser Arg Glu Gln Arg Ile Asp Gly Met Val Ile Trp Asp Trp Ala Cys 
                165                 170                 175     


Gly Thr Val Gly Arg Pro Cys Pro Lys Ile Ala Thr Glu Pro Glu Arg 
            180                 185                 190         


Ala Val Thr Phe Gly Pro Phe Lys Leu Pro Pro Pro Cys Leu Tyr Leu 
        195                 200                 205             


Leu Pro Ser Thr Ile Pro Ser Pro Arg Asn Asn Pro Ser Pro Arg Ala 
    210                 215                 220                 


Gln Gln Ile Glu Asp Val Gln Leu Ile Lys Ala Phe His Asp Cys Phe 
225                 230                 235                 240 


Gly Cys Arg Ser Glu Glu Val Asn Phe Val Asn Phe Asp Val Gly Tyr 
                245                 250                 255     


His Gly Lys Asp Thr Val Arg Lys Thr Thr Ile Ile Arg Asn Gly Met 
            260                 265                 270         


Val Glu Arg Glu Ser Glu Met Thr Ala Ile Arg Arg Ser 
        275                 280                 285 


<210>  31
<211>  219
<212>  PRT
<213>  Nocardia rubra

<400>  31

Met Gly Phe Leu Glu Asp Trp Asp Leu Ser Tyr Asp Glu Ile Asn Glu 
1               5                   10                  15      


Leu Leu Thr Asp Asn Pro Ser Leu Arg Ser Phe Val Met Gly Tyr Ala 
            20                  25                  30          


Ala Glu Ile Lys Cys Arg Asn Met Phe Phe Val Asp His Pro His Ile 
        35                  40                  45              


Thr Asn Ile Tyr Lys Pro Asp Asp His Asp Arg Thr Glu Lys Gly Asp 
    50                  55                  60                  


Trp Ile Ile Asn Tyr Lys Gly His Arg Ile Gly Val Glu Val Lys Ser 
65                  70                  75                  80  


Leu Gln Thr Asn Ser Leu Arg Leu Arg Arg Asp Gly Ser Val Arg Pro 
                85                  90                  95      


Asn Tyr Gln Cys Asp Ala Ser Asp Ala Arg Thr Val Ile Phe Ala Asp 
            100                 105                 110         


Gly Ser Glu Val His Thr Thr Ala Leu Leu Val Gly Glu Phe Asp Val 
        115                 120                 125             


Val Ala Val Asn Ile His Ala Phe Glu Asn Lys Trp Asp Phe Ala Phe 
    130                 135                 140                 


Ala Lys Asn Glu Asp Leu Ile Thr Met Glu Gly Ala Thr Arg Gly Ala 
145                 150                 155                 160 


Ala Lys Asp Tyr Thr Glu Leu Gln Lys Arg Asn Leu Ile Lys Thr Leu 
                165                 170                 175     


Gln Pro Met Pro Met Asp Val Pro Ala Pro Tyr Thr Arg Asp Pro Phe 
            180                 185                 190         


Lys Leu Phe Asp Glu Ile Ile Glu Glu Arg Met Lys Gly Glu Gln Pro 
        195                 200                 205             


Gln Leu Lys Ala Lys Ile Ile Glu Asp Glu Glu 
    210                 215                 


<210>  32
<211>  244
<212>  PRT
<213>  Nostoc species

<400>  32

Met Ser Lys Glu Gln Asn Leu Val Gln Thr Ile Gln Ser Gln Phe Arg 
1               5                   10                  15      


Gln Asp Ser Thr Gln Leu Gln Val Phe Lys Leu Leu Ser Asp Gln Gln 
            20                  25                  30          


Trp His Cys Arg Glu Cys Glu Gly Lys Lys Ile Gly Ser Asn Gln Tyr 
        35                  40                  45              


Ala Gly Gly Gly Gly Ile Gln Gly Leu Gln Arg Gly Thr Arg Ser Arg 
    50                  55                  60                  


Pro Gly Leu Val Ile Glu Thr Thr Lys Asn Tyr Cys Gln Thr Cys Gln 
65                  70                  75                  80  


Gln Thr Arg Leu Gly Asp Arg Trp Thr Gly Glu Ile Lys Ser Ala Asn 
                85                  90                  95      


Ser Ala Ser Asn Ile Pro Ala Ser Leu Val Glu Lys Ile Leu Gln Val 
            100                 105                 110         


Tyr Ser Tyr Thr Asp Val Ile Glu Gln Arg Gln Arg Glu Lys His Glu 
        115                 120                 125             


Leu Val Ile Asp His Arg Phe Pro Met Glu Arg Trp Gly Ala Ser Glu 
    130                 135                 140                 


Pro Pro His Leu Thr Ser Met Asn Asp Asn Glu Ile Lys Arg Lys Phe 
145                 150                 155                 160 


Gln Leu Leu Lys Lys Asp Thr Ser Gly Asn His Asn Leu Leu Lys Ser 
                165                 170                 175     


Arg Ser Cys Glu Arg Cys Ile Lys Thr Gly Lys Arg Gly Ala Pro Phe 
            180                 185                 190         


Gly Ile His Phe Trp Tyr Gln Gly Asp Glu Asn Trp Pro Ser Val His 
        195                 200                 205             


Gln Arg Gly Asp Glu Ala Glu Glu Gly Cys Val Gly Cys Gly Trp Tyr 
    210                 215                 220                 


Asn Phe Glu Ala Trp Arg Asn Ala Leu Asn Gln Lys Leu Ser Gln Ser 
225                 230                 235                 240 


Asp Gln His Lys 
                


<210>  33
<211>  293
<212>  PRT
<213>  Bacillus stearothermophilus

<400>  33

Met Met Thr Glu Leu Lys Asn Ser Asn Cys Ile Glu Glu Tyr Gln Glu 
1               5                   10                  15      


Asn Gly Lys Thr Lys Val Arg Ile Lys Pro Phe Asn Ala Leu Ile Glu 
            20                  25                  30          


Leu Tyr Asp Asn Gln Ile Pro Thr Gly Asn Ile Lys Glu Asn Leu Asp 
        35                  40                  45              


Lys Leu Gln Asn Tyr Val Met Lys Val Ala Asp Ala Lys Gly Leu Thr 
    50                  55                  60                  


Lys Pro Ala Ser Ala Ala Phe Ser Asn Thr Arg Gly Thr Trp Phe Glu 
65                  70                  75                  80  


Val Met Ile Ala Ile Gln Ser Trp Asn Tyr Arg Ile Lys Arg Gly Tyr 
                85                  90                  95      


Asn Asp Tyr Leu Ile Ile Lys Met Pro Asn Val Lys Thr Phe Asp Phe 
            100                 105                 110         


Arg Lys Ile Phe Asp Asp Glu Thr Arg Glu Lys Leu Tyr Gln Leu Glu 
        115                 120                 125             


Lys Ser Leu Leu Thr His Lys Gln Gln Val Arg Leu Ile Thr Ser Asn 
    130                 135                 140                 


Pro Asp Leu Leu Ile Ile Arg Gln Lys Asp Leu Ile Lys Asp Glu Tyr 
145                 150                 155                 160 


Asn Gln Pro Ile Asp Lys Phe Thr His Glu Asn Val Asp Thr Ala Leu 
                165                 170                 175     


Thr Leu Phe Lys His Leu Glu Arg Lys Cys Lys Trp Asp Ser Leu Val 
            180                 185                 190         


Ala Gly Ile Gly Leu Lys Thr Ser Leu Arg Pro Asp Arg Arg Leu Gln 
        195                 200                 205             


Leu Val His Glu Gly Asn Ile Leu Lys Ser Leu Phe Ala His Leu Lys 
    210                 215                 220                 


Met Arg Tyr Trp Asn Pro Lys Ala Glu Phe Lys Tyr Tyr Gly Ala Ser 
225                 230                 235                 240 


Ser Glu Pro Val Ser Gln Ala Asp Asp Asp Ala Leu Gln Thr Ala Ala 
                245                 250                 255     


Thr His Thr Ile Val Asn Val Asn Ser Thr Pro Glu Arg Ala Val Asp 
            260                 265                 270         


Asp Val Phe Ser Leu Thr Ser Phe Glu Asp Ile Asp Lys Met Leu Asp 
        275                 280                 285             


Gln Ile Ile Lys Lys 
    290             


<210>  34
<211>  300
<212>  PRT
<213>  Bacillus species

<400>  34

Met Ile Glu Thr Val Leu Glu Lys Val Thr Asn Lys Asn Asn Phe Val 
1               5                   10                  15      


Thr Leu Gln Asn Tyr Thr Asp Phe Ala Leu Tyr Phe Leu Glu Tyr Ile 
            20                  25                  30          


Gln Lys Asn Lys Gln Ala Thr Ile Val Ser Gln Asn Glu His Val Tyr 
        35                  40                  45              


Asn Phe Tyr Gln Tyr Asn Ser Glu Ala Asn Tyr Gln Val Thr Arg Pro 
    50                  55                  60                  


Phe Asn Ser Lys Ile Leu Tyr Ser His Gln Asp Phe Leu Asp Asn Leu 
65                  70                  75                  80  


Gly Glu Phe Asn Lys Ile Leu Lys Asp Leu Lys Ser Asp Arg Asn His 
                85                  90                  95      


Ala Lys Ile Leu Asp Arg Ser Ile Ile Asn Arg Thr Ile Tyr Thr Val 
            100                 105                 110         


Gln Gln Thr Ile Gly Phe Ala Leu Asp Gly Leu Asp Ala Asn Arg Thr 
        115                 120                 125             


Asn Val Ala Arg Lys Leu Asn Gly Asp Tyr Phe Glu Gln Leu Ile Leu 
    130                 135                 140                 


Leu Leu Leu Arg Glu Ile Gly Ala Pro Ala Asn Asn Gly Val Val Lys 
145                 150                 155                 160 


Val Pro Val Asn Met Glu Asp Lys Gln Leu Phe Asn Met Ser Tyr Gln 
                165                 170                 175     


His Asp Leu Ile Leu Lys Asp Lys Lys Gly Glu Val Lys Leu Ile Gly 
            180                 185                 190         


Ser Val Lys Thr Thr Ser Lys Asp Arg Ile Gly Lys Ile Phe Val Asp 
        195                 200                 205             


Lys Phe Leu Tyr Ser Lys Leu Thr Glu Thr Thr Val Pro His Ile Ala 
    210                 215                 220                 


Ile Phe Leu His Asp Val Gln Arg Lys Arg Asn Lys Asp Pro Gln Lys 
225                 230                 235                 240 


Phe Gly Ile Asn Gly Thr Phe Leu Ala Gly His Phe Lys Gly Tyr Thr 
                245                 250                 255     


Val Lys Leu Asn Pro Leu Asp Gly Val Tyr Tyr Phe Asp Pro Arg Pro 
            260                 265                 270         


Gln Met Gln Thr Asp Val Leu Leu Ser Glu His Ile Gln Thr Phe Asp 
        275                 280                 285             


His Leu Leu Cys Asp Asp Ile Trp Ser Tyr Val Asp 
    290                 295                 300 


<210>  35
<211>  213
<212>  PRT
<213>  Bacillus amyloliquefaciens

<400>  35

Met Glu Val Glu Lys Glu Phe Ile Thr Asp Glu Ala Lys Glu Leu Leu 
1               5                   10                  15      


Ser Lys Asp Lys Leu Ile Gln Gln Ala Tyr Asn Glu Val Lys Thr Ser 
            20                  25                  30          


Ile Cys Ser Pro Ile Trp Pro Ala Thr Ser Lys Thr Phe Thr Ile Asn 
        35                  40                  45              


Asn Thr Glu Lys Asn Cys Asn Gly Val Val Pro Ile Lys Glu Leu Cys 
    50                  55                  60                  


Tyr Thr Leu Leu Glu Asp Thr Tyr Asn Trp Tyr Arg Glu Lys Pro Leu 
65                  70                  75                  80  


Asp Ile Leu Lys Leu Glu Lys Lys Lys Gly Gly Pro Ile Asp Val Tyr 
                85                  90                  95      


Lys Glu Phe Ile Glu Asn Ser Glu Leu Lys Arg Val Gly Met Glu Phe 
            100                 105                 110         


Glu Thr Gly Asn Ile Ser Ser Ala His Arg Ser Met Asn Lys Leu Leu 
        115                 120                 125             


Leu Gly Leu Lys His Gly Glu Ile Asp Leu Ala Ile Ile Leu Met Pro 
    130                 135                 140                 


Ile Lys Gln Leu Ala Tyr Tyr Leu Thr Asp Arg Val Thr Asn Phe Glu 
145                 150                 155                 160 


Glu Leu Glu Pro Tyr Phe Glu Leu Thr Glu Gly Gln Pro Phe Ile Phe 
                165                 170                 175     


Ile Gly Phe Asn Ala Glu Ala Tyr Asn Ser Asn Val Pro Leu Ile Pro 
            180                 185                 190         


Lys Gly Ser Asp Gly Met Ser Lys Arg Ser Ile Lys Lys Trp Lys Asp 
        195                 200                 205             


Lys Val Glu Asn Lys 
    210             


