
                                SEQUENCE LISTING

<110> Chen, Jake Yue
      Shiaofen Fang
      Indiana University Resarch and Technology Corporation

<120> 4-PROTEIN BIOMARKER PANEL FOR THE
  DIAGNOSIS OF LYMPHOMA FROM BIOSPECIMEN
  

<130> 12972-00425W

<150> 61/301,520          
<151> 2010-02-04  

<150> 61/301,509          
<151> 2010-02-04  

<160> 8

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3686
<212> DNA
<213> Homo sapiens

<400> 1
atacgggaga actaaggctg aaacctcgga ggaacaacca cttttgaagt gacttcgcgg 60
cgtgcgttgg gtgcggacta ggtggccgcg gcgggagtgt gctggagcct gaagtccacg 120
cgcgcggctg agaaccgccg ggaccgcacg tgggcgccgc gcgcttcccc cgcttcccag 180
gtgggcgccg gccgccaggc cacctcacgt ccggccccgg ggatgcgcgt cctcctcgcc 240
gcgctgggac tgctgttcct gggggcgcta cgagccttcc cacaggatcg acccttcgag 300
gacacctgtc atggaaaccc cagccactac tatgacaagg ctgtcaggag gtgctgttac 360
cgctgcccca tggggctgtt cccgacacag cagtgcccac agaggcctac tgactgcagg 420
aagcagtgtg agcctgacta ctacctggat gaggccgacc gctgtacagc ctgcgtgact 480
tgttctcgag acgacctcgt ggagaagacg ccgtgtgcat ggaactcctc ccgtgtctgc 540
gaatgtcgac ccggcatgtt ctgttccacg tctgccgtca actcctgtgc ccgctgcttc 600
ttccattctg tctgtccggc agggatgatt gtcaagttcc caggcacggc gcagaagaac 660
acggtctgtg agccggcttc cccaggggtc agccctgcct gtgccagccc agagaactgc 720
aaggaaccct ccagtggcac catcccccag gccaagccca ccccggtgtc cccagcaacc 780
tccagtgcca gcaccatgcc tgtaagaggg ggcacccgcc tcgcccagga agctgcttct 840
aaactgacga gggctcccga ctctccctcc tctgtgggaa ggcctagttc agatccaggt 900
ctgtccccaa cacagccatg cccagagggg tctggtgatt gcagaaagca gtgtgagccc 960
gactactacc tggacgaggc cggccgctgc acggcctgcg tgagctgttc tcgagatgac 1020
cttgtggaga agacgccatg tgcatggaac tcctcccgca cctgcgaatg tcgacctggc 1080
atgatctgtg ccacatcagc caccaactcc cgtgcccgct gtgtccccta cccaatctgt 1140
gcagcagaga cggtcaccaa gccccaggat atggctgaga aggacaccac ctttgaggcg 1200
ccacccctgg ggacccagcc ggactgcaac cccaccccag agaatggcga ggcgcctgcc 1260
agcaccagcc ccactcagag cttgctggtg gactcccagg ccagtaagac gctgcccatc 1320
ccaaccagcg ctcccgtcgc tctctcctcc acggggaagc ccgttctgga tgcagggcca 1380
gtgctcttct gggtgatcct ggtgttggtt gtggtggtcg gctccagcgc cttcctcctg 1440
tgccaccgga gggcctgcag gaagcgaatt cggcagaagc tccacctgtg ctacccggtc 1500
cagacctccc agcccaagct agagcttgtg gattccagac ccaggaggag ctcaacgcag 1560
ctgaggagtg gtgcgtcggt gacagaaccc gtcgcggaag agcgagggtt aatgagccag 1620
ccactgatgg agacctgcca cagcgtgggg gcagcctacc tggagagcct gccgctgcag 1680
gatgccagcc cggccggggg cccctcgtcc cccagggacc ttcctgagcc ccgggtgtcc 1740
acggagcaca ccaataacaa gattgagaaa atctacatca tgaaggctga caccgtgatc 1800
gtggggaccg tgaaggctga gctgccggag ggccggggcc tggcggggcc agcagagccc 1860
gagttggagg aggagctgga ggcggaccat accccccact accccgagca ggagacagaa 1920
ccgcctctgg gcagctgcag cgatgtcatg ctctcagtgg aagaggaagg gaaagaagac 1980
cccttgccca cagctgcctc tggaaagtga ggcctgggct gggctggggc taggagggca 2040
gcagggtggc ctctgggagg ccaggatggc actgttggca ccgaggttgg gggcagaggc 2100
ccatctggcc tgaactgagg ctccagcatc tagtggtgga ccggccggtc actgcagggg 2160
tctggtggtc tctgcttgca tccccaactt agctgtcccc tgacccagag cctaggggat 2220
ccggggcttg tacagaagag acagtccaag gggactggat cccagcagtg atgttggttg 2280
aggcagcaaa cagatggcag gatgggcact gccgagaaca gcattggtcc cagagccctg 2340
ggcatcagac cttaaccacc aggcccacag cccagcgagg gagaggtcgt gaggccagct 2400
cccggggccc ctgtaaccct actctcctct ctccctggac ctcagaggtg acacccattg 2460
ggcccttccg gcatgccccc agttactgta aatgtggccc ccagtgggca tggagccagt 2520
gcctgtggtt gtttctccag agtcaaaagg gaagtcgagg gatggggcgt cgtcagctgg 2580
cactgtctct gctgcagcgg ccacactgta ctctgcactg gtgtgagggc ccctgcctgg 2640
actgtgggac cctcctggtg ctgcccacct tccctgtcct gtagccccct cggtgggccc 2700
agggcctagg gcccaggatc aagtcactca tctcagaatg tccccaccaa tccccgccac 2760
agcaggcgcc tcgggtccca gatgtctgca gccctcagca gctgcagacc gcccctcacc 2820
aacccagaga acctgcttta ctttgcccag ggacttcctc cccatgtgaa catggggaac 2880
ttcgggccct gcctggagtc cttgaccgct ctctgtgggc cccacccact ctgtcctggg 2940
aaatgaagaa gcatcttcct taggtctgcc ctgcttgcaa atccactagc accgacccca 3000
ccacctggtt ccggctctgc acgctttggg gtgtggatgt cgagaggcac cacggcctca 3060
cccaggcatc tgctttactc tggaccatag gaaacaagac cgtttggagg tttcatcagg 3120
attttgggtt tttcacattt cacgctaagg agtagtggcc ctgacttccg gtcggctggc 3180
cagctgactc cctagggcct tcagacgtgt atgcaaatga gtgatggata aggatgagtc 3240
ttggagttgc gggcagcctg gagactcgtg gacttaccgc ctggaggcag gcccgggaag 3300
gctgctgttt actcatcggg cagccacgtg ctctctggag gaagtgatag tttctgaaac 3360
cgctcagatg ttttggggaa agttggagaa gccgtggcct tgcgagaggt ggttacacca 3420
gaacctggac attggccaga agaagcttaa gtgggcagac actgtttgcc cagtgtttgt 3480
gcaaggatgg agtgggtgtc tctgcatcac ccacagccgc agctgtaagg cacgctggaa 3540
ggcacacgcc tgccaggcag ggcagtctgg cgcccatgat gggagggatt gacatgtttc 3600
aacaaaataa tgcacttcct tacctagtgg cccttcacac aacttttgaa tctctaaaaa 3660
tccataaaat ccttaaagaa ctgtaa                                      3686

<210> 2
<211> 595
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15      
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30          
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45              
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60                  
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80  
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95      
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110         
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125             
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140                 
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160 
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175     
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190         
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205             
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220                 
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240 
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255     
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270         
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285             
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300                 
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320 
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335     
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350         
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365             
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380                 
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400 
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415     
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430         
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445             
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460                 
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480 
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495     
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510         
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525             
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540                 
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560 
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575     
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590         
Ser Gly Lys
        595 


<210> 3
<211> 2780
<212> DNA
<213> Homo sapiens

<400> 3
gctgcggagg gtgcgtgcgg gccgcggcag ccgaacaaag gagcaggggc gccgccgcag 60
ggacccgcca cccacctccc ggggccgcgc agcggcctct cgtctactgc caccatgacc 120
gccaacggca cagccgaggc ggtgcagatc cagttcggcc tcatcaactg cggcaacaag 180
tacctgacgg ccgaggcgtt cgggttcaag gtgaacgcgt ccgccagcag cctgaagaag 240
aagcagatct ggacgctgga gcagccccct gacgaggcgg gcagcgcggc cgtgtgcctg 300
cgcagccacc tgggccgcta cctggcggcg gacaaggacg gcaacgtgac ctgcgagcgc 360
gaggtgcccg gtcccgactg ccgtttcctc atcgtggcgc acgacgacgg tcgctggtcg 420
ctgcagtccg aggcgcaccg gcgctacttc ggcggcaccg aggaccgcct gtcctgcttc 480
gcgcagacgg tgtcccccgc cgagaagtgg agcgtgcaca tcgccatgca ccctcaggtc 540
aacatctaca gcgtcacccg taagcgctac gcgcacctga gcgcgcggcc ggccgacgag 600
atcgccgtgg accgcgacgt gccctggggc gtcgactcgc tcatcaccct cgccttccag 660
gaccagcgct acagcgtgca gaccgccgac caccgcttcc tgcgccacga cgggcgcctg 720
gtggcgcgcc ccgagccggc cactggctac acgctggagt tccgctccgg caaggtggcc 780
ttccgcgact gcgagggccg ttacctggcg ccgtcggggc ccagcggcac gctcaaggcg 840
ggcaaggcca ccaaggtggg caaggacgag ctctttgctc tggagcagag ctgcgcccag 900
gtcgtgctgc aggcggccaa cgagaggaac gtgtccacgc gccagggtat ggacctgtct 960
gccaatcagg acgaggagac cgaccaggag accttccagc tggagatcga ccgcgacacc 1020
aaaaagtgtg ccttccgtac ccacacgggc aagtactgga cgctgacggc caccgggggc 1080
gtgcagtcca ccgcctccag caagaatgcc agctgctact ttgacatcga gtggcgtgac 1140
cggcgcatca cactgagggc gtccaatggc aagtttgtga cctccaagaa gaatgggcag 1200
ctggccgcct cggtggagac agcaggggac tcagagctct tcctcatgaa gctcatcaac 1260
cgccccatca tcgtgttccg cggggagcat ggcttcatcg gctgccgcaa ggtcacgggc 1320
accctggacg ccaaccgctc cagctatgac gtcttccagc tggagttcaa cgatggcgcc 1380
tacaacatca aagactccac aggcaaatac tggacggtgg gcagtgactc cgcggtcacc 1440
agcagcggcg acactcctgt ggacttcttc ttcgagttct gcgactataa caaggtggcc 1500
atcaaggtgg gcgggcgcta cctgaagggc gaccacgcag gcgtcctgaa ggcctcggcg 1560
gaaaccgtgg accccgcctc gctctgggag tactagggcc ggcccgtcct tccccgcccc 1620
tgcccacatg gcggctcctg ccaaccctcc ctgctaaccc cttctccgcc aggtgggctc 1680
cagggcggga ggcaagcccc cttgcctttc aaactggaaa ccccagagaa aacggtgccc 1740
ccacctgtcg cccctatgga ctccccactc tcccctccgc ccgggttccc tactcccctc 1800
gggtcagcgg ctgcggcctg gccctgggag ggatttcaga tgcccctgcc ctcttgtctg 1860
ccacggggcg agtctggcac ctctttcttc tgacctcaga cggctctgag ccttatttct 1920
ctggaagcgg ctaagggacg gttgggggct gggagccctg ggcgtgtagt gtaactggaa 1980
tcttttgcct ctcccagcca cctcctccca gccccccagg agagctgggc acatgtccca 2040
agcctgtcag tggccctccc tggtgcactg tccccgaaac ccctgcttgg gaagggaagc 2100
tgtcgggtgg gctaggactg acccttgtgg tgtttttttg ggtggtggct ggaaacagcc 2160
cctctcccac gtggcagagg ctcagcctgg ctcccttccc tggagcggca gggcgtgacg 2220
gccacagggt ctgcccgctg cacgttctgc caaggtggtg gtggcgggcg ggtaggggtg 2280
tgggggccgt cttcctcctg tctctttcct ttcaccctag cctgactgga agcagaaaat 2340
gaccaaatca gtattttttt taatgaaata ttattgctgg aggcgtccca ggcaagcctg 2400
gctgtagtag cgagtgatct ggcggggggc gtctcagcac cctccccagg gggtgcatct 2460
cagccccctc tttccgtcct tcccgtccag ccccagccct gggcctgggc tgccgacacc 2520
tgggccagag cccctgctgt gattggtgct ccctgggcct cccgggtgga tgaagccagg 2580
cgtcgccccc tccgggagcc ctggggtgag ccgccggggc ccccctgctg ccagcctccc 2640
ccgtccccaa catgcatctc actctgggtg tcttggtctt ttattttttg taagtgtcat 2700
ttgtataact ctaaacgccc atgatagtag cttcaaactg gaaatagcga aataaaataa 2760
ctcagtctgc agccccaaaa                                             2780

<210> 4
<211> 493
<212> PRT
<213> Homo sapiens

<400> 4
Met Thr Ala Asn Gly Thr Ala Glu Ala Val Gln Ile Gln Phe Gly Leu
 1               5                  10                  15      
Ile Asn Cys Gly Asn Lys Tyr Leu Thr Ala Glu Ala Phe Gly Phe Lys
            20                  25                  30          
Val Asn Ala Ser Ala Ser Ser Leu Lys Lys Lys Gln Ile Trp Thr Leu
        35                  40                  45              
Glu Gln Pro Pro Asp Glu Ala Gly Ser Ala Ala Val Cys Leu Arg Ser
    50                  55                  60                  
His Leu Gly Arg Tyr Leu Ala Ala Asp Lys Asp Gly Asn Val Thr Cys
65                  70                  75                  80  
Glu Arg Glu Val Pro Gly Pro Asp Cys Arg Phe Leu Ile Val Ala His
                85                  90                  95      
Asp Asp Gly Arg Trp Ser Leu Gln Ser Glu Ala His Arg Arg Tyr Phe
            100                 105                 110         
Gly Gly Thr Glu Asp Arg Leu Ser Cys Phe Ala Gln Thr Val Ser Pro
        115                 120                 125             
Ala Glu Lys Trp Ser Val His Ile Ala Met His Pro Gln Val Asn Ile
    130                 135                 140                 
Tyr Ser Val Thr Arg Lys Arg Tyr Ala His Leu Ser Ala Arg Pro Ala
145                 150                 155                 160 
Asp Glu Ile Ala Val Asp Arg Asp Val Pro Trp Gly Val Asp Ser Leu
                165                 170                 175     
Ile Thr Leu Ala Phe Gln Asp Gln Arg Tyr Ser Val Gln Thr Ala Asp
            180                 185                 190         
His Arg Phe Leu Arg His Asp Gly Arg Leu Val Ala Arg Pro Glu Pro
        195                 200                 205             
Ala Thr Gly Tyr Thr Leu Glu Phe Arg Ser Gly Lys Val Ala Phe Arg
    210                 215                 220                 
Asp Cys Glu Gly Arg Tyr Leu Ala Pro Ser Gly Pro Ser Gly Thr Leu
225                 230                 235                 240 
Lys Ala Gly Lys Ala Thr Lys Val Gly Lys Asp Glu Leu Phe Ala Leu
                245                 250                 255     
Glu Gln Ser Cys Ala Gln Val Val Leu Gln Ala Ala Asn Glu Arg Asn
            260                 265                 270         
Val Ser Thr Arg Gln Gly Met Asp Leu Ser Ala Asn Gln Asp Glu Glu
        275                 280                 285             
Thr Asp Gln Glu Thr Phe Gln Leu Glu Ile Asp Arg Asp Thr Lys Lys
    290                 295                 300                 
Cys Ala Phe Arg Thr His Thr Gly Lys Tyr Trp Thr Leu Thr Ala Thr
305                 310                 315                 320 
Gly Gly Val Gln Ser Thr Ala Ser Ser Lys Asn Ala Ser Cys Tyr Phe
                325                 330                 335     
Asp Ile Glu Trp Arg Asp Arg Arg Ile Thr Leu Arg Ala Ser Asn Gly
            340                 345                 350         
Lys Phe Val Thr Ser Lys Lys Asn Gly Gln Leu Ala Ala Ser Val Glu
        355                 360                 365             
Thr Ala Gly Asp Ser Glu Leu Phe Leu Met Lys Leu Ile Asn Arg Pro
    370                 375                 380                 
Ile Ile Val Phe Arg Gly Glu His Gly Phe Ile Gly Cys Arg Lys Val
385                 390                 395                 400 
Thr Gly Thr Leu Asp Ala Asn Arg Ser Ser Tyr Asp Val Phe Gln Leu
                405                 410                 415     
Glu Phe Asn Asp Gly Ala Tyr Asn Ile Lys Asp Ser Thr Gly Lys Tyr
            420                 425                 430         
Trp Thr Val Gly Ser Asp Ser Ala Val Thr Ser Ser Gly Asp Thr Pro
        435                 440                 445             
Val Asp Phe Phe Phe Glu Phe Cys Asp Tyr Asn Lys Val Ala Ile Lys
    450                 455                 460                 
Val Gly Gly Arg Tyr Leu Lys Gly Asp His Ala Gly Val Leu Lys Ala
465                 470                 475                 480 
Ser Ala Glu Thr Val Asp Pro Ala Ser Leu Trp Glu Tyr
                485                 490             


<210> 5
<211> 3569
<212> DNA
<213> Homo sapiens

<400> 5
accatcgtct tgggcccggg gagggagagc caccttcagg cccctcgagc ctcgaaccgg 60
aacctccaaa tccgagacgc tctgcttatg aggacctcga aatatgccgg ccagtgaaaa 120
aatcttgtgg ctttgagggc ttttggttgg ccaggggcag taaaaatctc ggagagctga 180
caccaagtcc tcccctgcca cgtagcagtg gtaaagtccg aagctcaaat tccgagaatt 240
gagctctgtt gattcttaga actggggttc ttagaagtgg tgatgcaaga agtttctagg 300
aaaggccgga caccaggttt tgagcaaaat tttggactgt gaagcaaggc attggtgaag 360
acaaaatggc ctcgccggct gacagctgta tccagttcac ccgccatgcc agtgatgttc 420
ttctcaacct taatcgtctc cggagtcgag acatcttgac tgatgttgtc attgttgtga 480
gccgtgagca gtttagagcc cataaaacgg tcctcatggc ctgcagtggc ctgttctata 540
gcatctttac agaccagttg aaatgcaacc ttagtgtgat caatctagat cctgagatca 600
accctgaggg attctgcatc ctcctggact tcatgtacac atctcggctc aatttgcggg 660
agggcaacat catggctgtg atggccacgg ctatgtacct gcagatggag catgttgtgg 720
acacttgccg gaagtttatt aaggccagtg aagcagagat ggtttctgcc atcaagcctc 780
ctcgtgaaga gttcctcaac agccggatgc tgatgcccca agacatcatg gcctatcggg 840
gtcgtgaggt ggtggagaac aacctgccac tgaggagcgc ccctgggtgt gagagcagag 900
cctttgcccc cagcctgtac agtggcctgt ccacaccgcc agcctcttat tccatgtaca 960
gccacctccc tgtcagcagc ctcctcttct ccgatgagga gtttcgggat gtccggatgc 1020
ctgtggccaa ccccttcccc aaggagcggg cactcccatg tgatagtgcc aggccagtcc 1080
ctggtgagta cagccggccg actttggagg tgtcccccaa tgtgtgccac agcaatatct 1140
attcacccaa ggaaacaatc ccagaagagg cacgaagtga tatgcactac agtgtggctg 1200
agggcctcaa acctgctgcc ccctcagccc gaaatgcccc ctacttccct tgtgacaagg 1260
ccagcaaaga agaagagaga ccctcctcgg aagatgagat tgccctgcat ttcgagcccc 1320
ccaatgcacc cctgaaccgg aagggtctgg ttagtccaca gagcccccag aaatctgact 1380
gccagcccaa ctcgcccaca gagtcctgca gcagtaagaa tgcctgcatc ctccaggctt 1440
ctggctcccc tccagccaag agccccactg accccaaagc ctgcaactgg aagaaataca 1500
agttcatcgt gctcaacagc ctcaaccaga atgccaaacc agaggggcct gagcaggctg 1560
agctgggccg cctttcccca cgagcctaca cggccccacc tgcctgccag ccacccatgg 1620
agcctgagaa ccttgacctc cagtccccaa ccaagctgag tgccagcggg gaggactcca 1680
ccatcccaca agccagccgg ctcaataaca tcgttaacag gtccatgacg ggctctcccc 1740
gcagcagcag cgagagccac tcaccactct acatgcaccc cccgaagtgc acgtcctgcg 1800
gctctcagtc cccacagcat gcagagatgt gcctccacac cgctggcccc acgttccctg 1860
aggagatggg agagacccag tctgagtact cagattctag ctgtgagaac ggggccttct 1920
tctgcaatga gtgtgactgc cgcttctctg aggaggcctc actcaagagg cacacgctgc 1980
agacccacag tgacaaaccc tacaagtgtg accgctgcca ggcctccttc cgctacaagg 2040
gcaacctcgc cagccacaag accgtccata ccggtgagaa accctatcgt tgcaacatct 2100
gtggggccca gttcaaccgg ccagccaacc tgaaaaccca cactcgaatt cactctggag 2160
agaagcccta caaatgcgaa acctgcggag ccagatttgt acaggtggcc cacctccgtg 2220
cccatgtgct tatccacact ggtgagaagc cctatccctg tgaaatctgt ggcacccgtt 2280
tccggcacct tcagactctg aagagccacc tgcgaatcca cacaggagag aaaccttacc 2340
attgtgagaa gtgtaacctg catttccgtc acaaaagcca gctgcgactt cacttgcgcc 2400
agaagcatgg cgccatcacc aacaccaagg tgcaataccg cgtgtcagcc actgacctgc 2460
ctccggagct ccccaaagcc tgctgaagca tggagtgttg atgctttcgt ctccagcccc 2520
ttctcagaat ctacccaaag gatactgtaa cactttacaa tgttcatccc atgatgtagt 2580
gcctctttca tccactagtg caaatcatag ctgggggttg ggggtggtgg gggtcggggc 2640
ctgggggact gggagccgca gcagctcccc ctcccccact gccataaaac attaagaaaa 2700
tcatattgct tcttctccta tgtgtaaggt gaaccatgtc agcaaaaagc aaaatcattt 2760
tatatgtcaa agcaggggag tatgcaaaag ttctgacttg actttagtct gcaaaatgag 2820
gaatgtatat gttttgtggg aacagatgtt tcttttgtat gtaaatgtgc attcttttaa 2880
aagacaagac ttcagtatgt tgtcaaagag agggctttaa tttttttaac caaaggtgaa 2940
ggaatatatg gcagagttgt aaatatataa atatatatat atataaaata aatatatata 3000
aacctaaaaa agatatatta aaaatataaa actgcgttaa aggctcgatt ttgtatctgc 3060
aggcagacac ggatctgaga atctttattg agaaagagca cttaagagaa tattttaagt 3120
attgcatctg tataagtaag aaaatatttt gtctaaaatg cctcagtgta tttgtatttt 3180
tttgcaagtg aaggtttaca atttacaaag tgtgtattaa aaaaaacaaa aagaacaaaa 3240
aaatctgcag aaggaaaaat gtgtaatttt gttctagttt tcagtttgta tatacccgta 3300
caacgtgtcc tcacggtgcc ttttttcacg gaagttttca atgatgggcg agcgtgcacc 3360
atcccttttt gaagtgtagg cagacacagg gacttgaagt tgttactaac taaactctct 3420
ttgggaatgt ttgtctcatc ccattctgcg tcatgcttgt gttataacta ctccggagac 3480
agggtttggc tgtgtctaaa ctgcattacc gcgttgtaaa atatagctgt acaaatataa 3540
gaataaaatg ttgaaaagtc aaactggaa                                   3569

<210> 6
<211> 706
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser
 1               5                  10                  15      
Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr
            20                  25                  30          
Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr
        35                  40                  45              
Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln
    50                  55                  60                  
Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro
65                  70                  75                  80  
Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn
                85                  90                  95      
Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Thr Ala Met Tyr Leu
            100                 105                 110         
Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser
        115                 120                 125             
Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu
    130                 135                 140                 
Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg
145                 150                 155                 160 
Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu
                165                 170                 175     
Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Thr Pro Pro
            180                 185                 190         
Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe
        195                 200                 205             
Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe
    210                 215                 220                 
Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly
225                 230                 235                 240 
Glu Tyr Ser Arg Pro Thr Leu Glu Val Ser Pro Asn Val Cys His Ser
                245                 250                 255     
Asn Ile Tyr Ser Pro Lys Glu Thr Ile Pro Glu Glu Ala Arg Ser Asp
            260                 265                 270         
Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala
        275                 280                 285             
Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu
    290                 295                 300                 
Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn
305                 310                 315                 320 
Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys
                325                 330                 335     
Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys Asn
            340                 345                 350         
Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Thr
        355                 360                 365             
Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn
    370                 375                 380                 
Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu
385                 390                 395                 400 
Gly Arg Leu Ser Pro Arg Ala Tyr Thr Ala Pro Pro Ala Cys Gln Pro
                405                 410                 415     
Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu Ser
            420                 425                 430         
Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn Asn
        435                 440                 445             
Ile Val Asn Arg Ser Met Thr Gly Ser Pro Arg Ser Ser Ser Glu Ser
    450                 455                 460                 
His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly Ser
465                 470                 475                 480 
Gln Ser Pro Gln His Ala Glu Met Cys Leu His Thr Ala Gly Pro Thr
                485                 490                 495     
Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser Ser
            500                 505                 510         
Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser
        515                 520                 525             
Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp Lys
    530                 535                 540                 
Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn
545                 550                 555                 560 
Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg Cys
                565                 570                 575     
Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr His
            580                 585                 590         
Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys Gly
        595                 600                 605             
Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His
    610                 615                 620                 
Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe Arg
625                 630                 635                 640 
His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu Lys
                645                 650                 655     
Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser Gln
            660                 665                 670         
Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr Lys
        675                 680                 685             
Val Gln Tyr Arg Val Ser Ala Thr Asp Leu Pro Pro Glu Leu Pro Lys
    690                 695                 700                 
Ala Cys
705     


<210> 7
<211> 2709
<212> DNA
<213> Homo sapiens

<400> 7
ccctttactc ctggctgcgg ggcgagccgg gcgtctgctg cagcggccgc ggtggctgag 60
gaggcccgag aggagtcggt ggcagcggcg gcggcgggac cggcagcagc agcagcagca 120
gcagcagcag caaccactag cctcctgccc cgcggcgctg ccgcacgagc cccacgagcc 180
gctcaccccg ccgttctcag cgctgcccga ccccgctggc gcgccctccc gccgccagtc 240
ccggcagcgc cctcagttgt cctccgactc gccctcggcc ttccgcgcca gccgcagcca 300
cagccgcaac gccacccgca gccacagcca cagccacagc cccaggcata gccttcggca 360
cagccccggc tccggctcct gcggcagctc ctctgggcac cgtccctgcg ccgacatcct 420
ggaggttggg atgctcttgt ccaaaatcaa ctcgcttgcc cacctgcgcg ccgcgccctg 480
caacgacctg cacgccacca agctggcgcc cggcaaggag aaggagcccc tggagtcgca 540
gtaccaggtg ggcccgctac tgggcagcgg cggcttcggc tcggtctact caggcatccg 600
cgtctccgac aacttgccgg tggccatcaa acacgtggag aaggaccgga tttccgactg 660
gggagagctg cctaatggca ctcgagtgcc catggaagtg gtcctgctga agaaggtgag 720
ctcgggtttc tccggcgtca ttaggctcct ggactggttc gagaggcccg acagtttcgt 780
cctgatcctg gagaggcccg agccggtgca agatctcttc gacttcatca cggaaagggg 840
agccctgcaa gaggagctgg cccgcagctt cttctggcag gtgctggagg ccgtgcggca 900
ctgccacaac tgcggggtgc tccaccgcga catcaaggac gaaaacatcc ttatcgacct 960
caatcgcggc gagctcaagc tcatcgactt cgggtcgggg gcgctgctca aggacaccgt 1020
ctacacggac ttcgatggga cccgagtgta tagccctcca gagtggatcc gctaccatcg 1080
ctaccatggc aggtcggcgg cagtctggtc cctggggatc ctgctgtatg atatggtgtg 1140
tggagatatt cctttcgagc atgacgaaga gatcatcagg ggccaggttt tcttcaggca 1200
gagggtctct tcagaatgtc agcatctcat tagatggtgc ttggccctga gaccatcaga 1260
taggccaacc ttcgaagaaa tccagaacca tccatggatg caagatgttc tcctgcccca 1320
ggaaactgct gagatccacc tccacagcct gtcgccgggg cccagcaaat agcagccttt 1380
ctggcaggtc ctcccctctc ttgtcagatg cccgagggag gggaagcttc tgtctccagc 1440
ttcccgagta ccagtgacac gtctcgccaa gcaggacagt gcttgataca ggaacaacat 1500
ttacaactca ttccagatcc caggcccctg gaggctgcct cccaacagtg gggaagagtg 1560
actctccagg ggtcctaggc ctcaactcct cccatagata ctctcttctt ctcataggtg 1620
tccagcattg ctggactctg aaatatcccg ggggtggggg gtgggggtgg gtcagaaccc 1680
tgccatggaa ctgtttcctt catcatgagt tctgctgaat gccgcgatgg gtcaggtagg 1740
ggggaaacag gttgggatgg gataggacta gcaccatttt aagtccctgt cacctcttcc 1800
gactctttct gagtgccttc tgtggggact ccggctgtgc tgggagaaat acttgaactt 1860
gcctctttta cctgctgctt ctccaaaaat ctgcctgggt tttgttccct atttttctct 1920
cctgtcctcc ctcaccccct ccttcatatg aaaggtgcca tggaagaggc tacagggcca 1980
aacgctgagc cacctgccct tttttctgcc tcctttagta aaactccgag tgaactggtc 2040
ttcctttttg gtttttactt aactgtttca aagccaagac ctcacacaca caaaaaatgc 2100
acaaacaatg caatcaacag aaaagctgta aatgtgtgta cagttggcat ggtagtatac 2160
aaaaagattg tagtggatct aatttttaag aaattttgcc tttaagttat tttacctgtt 2220
tttgtttctt gttttgaaag atgcgcattc taacctggag gtcaatgtta tgtatttatt 2280
tatttattta tttggttccc ttcctattcc aagcttccat agctgctgcc ctagttttct 2340
ttcctccttt cctcctctga cttggggacc ttttggggga gggctgcgac gcttgctctg 2400
tttgtggggt gacgggactc aggcgggaca gtgctgcagc tccctggctt ctgtggggcc 2460
cctcacctac ttacccaggt gggtcccggc tctgtgggtg atggggaggg gcattgctga 2520
ctgtgtatat aggataatta tgaaaagcag ttctggatgg tgtgccttcc agatcctctc 2580
tggggctgtg ttttgagcag caggtagcct gctggtttta tctgagtgaa atactgtaca 2640
ggggaataaa agagatctta tttttttttt tatacttggc gttttttgaa taaaaacctt 2700
ttgtcttaa                                                         2709

<210> 8
<211> 404
<212> PRT
<213> Homo sapiens

<400> 8
Met Pro His Glu Pro His Glu Pro Leu Thr Pro Pro Phe Ser Ala Leu
 1               5                  10                  15      
Pro Asp Pro Ala Gly Ala Pro Ser Arg Arg Gln Ser Arg Gln Arg Pro
            20                  25                  30          
Gln Leu Ser Ser Asp Ser Pro Ser Ala Phe Arg Ala Ser Arg Ser His
        35                  40                  45              
Ser Arg Asn Ala Thr Arg Ser His Ser His Ser His Ser Pro Arg His
    50                  55                  60                  
Ser Leu Arg His Ser Pro Gly Ser Gly Ser Cys Gly Ser Ser Ser Gly
65                  70                  75                  80  
His Arg Pro Cys Ala Asp Ile Leu Glu Val Gly Met Leu Leu Ser Lys
                85                  90                  95      
Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro Cys Asn Asp Leu His
            100                 105                 110         
Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu Pro Leu Glu Ser Gln
        115                 120                 125             
Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly Phe Gly Ser Val Tyr
    130                 135                 140                 
Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val Ala Ile Lys His Val
145                 150                 155                 160 
Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu Pro Asn Gly Thr Arg
                165                 170                 175     
Val Pro Met Glu Val Val Leu Leu Lys Lys Val Ser Ser Gly Phe Ser
            180                 185                 190         
Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg Pro Asp Ser Phe Val
        195                 200                 205             
Leu Ile Leu Glu Arg Pro Glu Pro Val Gln Asp Leu Phe Asp Phe Ile
    210                 215                 220                 
Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala Arg Ser Phe Phe Trp
225                 230                 235                 240 
Gln Val Leu Glu Ala Val Arg His Cys His Asn Cys Gly Val Leu His
                245                 250                 255     
Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp Leu Asn Arg Gly Glu
            260                 265                 270         
Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu Lys Asp Thr Val
        275                 280                 285             
Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp Ile
    290                 295                 300                 
Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala Val Trp Ser Leu Gly
305                 310                 315                 320 
Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu His Asp
                325                 330                 335     
Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg Gln Arg Val Ser Ser
            340                 345                 350         
Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala Leu Arg Pro Ser Asp
        355                 360                 365             
Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro Trp Met Gln Asp Val
    370                 375                 380                 
Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu His Ser Leu Ser Pro
385                 390                 395                 400 
Gly Pro Ser Lys
                

