                        SEQUENCE LISTING

<110>  Epiontis GmbH
 
<120>  Assay for determining the type and/or status of a cell based on 
       the epigenetic pattern and the chromatin structure

<130>  E31434PCT

<150>  EP 10001121.2
<151>  2010-02-03

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid insert containing methylation segments

<400>  1
gcggccgccc taaacactac cacatctcaa aaccccttaa aaaaaaccat caaccccata       60

acacaaacca taacaactaa atttctgatc gtttttgatt tgtttagatt tttttgttat      120

tgatgttatg gtggttggat gtgttgggtt ttattgatat tatggaggaa gagaagaggc      180

tcgacccaaa cccctacctc cacatctaca taataaaaac cattaaccct catcaataaa      240

tctacatttc ctcaaaccta cactatctaa aattatacaa aactaataaa aaaacaaaat      300

ctcttctata ttcagtcgga atagaggaga agagagagtt tcattttttt ggttttttag      360

aaggaacatg agaatacatg tttgtgttga gagtgggtta gagcagtttt agggtaaagt      420

atgtggataa gtcggttttt ggtattgtag gttttgggat gttagtgtgt agtgggtgta      480

tttttgtttg gatgttgtgt ttgtggtaga gtggttgtta tgttgtaatt ggagtcgttt      540

tttttaaaga gtgtttttga tagggattgt tttaggaatt aggtaggaga gaagggagtg      600

tgagaggtga aagttattat tattctcgag                                       630


<210>  2
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  2
cttctctaaa cccaacatca at                                                22


<210>  3
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  3
gaatttagga ggtagaggtg gt                                                22


<210>  4
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  4
ggatatttga tttgggagtt ta                                                22


<210>  5
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  5
aaccactaac aacttctatt ttca                                              24


<210>  6
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  6
ttttgtgtta atatgaggtt gttt                                              24


<210>  7
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  7
accctctccc tactcaaata ct                                                22


<210>  8
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  8
agtggtataa ttttgttttg atttt                                             25


<210>  9
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  9
aaattctcat cctcccacta a                                                 21


<210>  10
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  10
acccacaaac ctacattaaa aa                                                22


<210>  11
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  11
gtaaggagag tgatgaggaa aa                                                22


<210>  12
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  12
caattcacaa atcccataaa ta                                                22


<210>  13
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  13
ttgtttaggt gaggataggt tt                                                22


<210>  14
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  14
aggtatttta agggtttgaa tg                                                22


<210>  15
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  bisulfite converted

<400>  15
tctcctcaca atctaacaaa aa                                                22


<210>  16
<211>  455
<212>  DNA
<213>  Homo sapiens

<400>  16
gaacccagga ggcagaggtg gcagtgagcc gagaccgtgc cattgcactc cagcctgggt       60

gacagagcga gactccgtct taaaaaataa ataaaacagg gtaaaaacac agaagttaca      120

gaagcctggc aggaaaagcc aaagacagaa ggctgacgga ggctttaaac gcacttcgtt      180

gacattcagg accctcggga atattcctcg gccctacggg ggtgggggtg tgcttgttct      240

tattttggtc tcacatcctt ctcaggccag ccttcctcct cctgcatggc caagcagggt      300

gagtccttcc ttgggaggcc gcctgttctc tccccgcctc ctggttctgg atttgggtag      360

ggcaggattt gggtgttcac cctcctagga ggccctgaga ggctgccagg ccccagctct      420

gcttcctcca cccactgatg ctgggctcag agaag                                 455


<210>  17
<211>  427
<212>  DNA
<213>  Homo sapiens

<400>  17
agccactgac agcttctatt ttcatagacc taaatatggg cttgccaccc ggataacatt       60

acacgcatgg cctctcctgg tgctccccac acccgggtga agtccgtgtt attattatct      120

ccatttctca ggtaagagaa ttgggtgaga actagagatg ttaagcagca agttcccaca      180

gggctgaagg aggtgagtgg tagcgtcaag atgtgaacca ctgttactgc acactgaatc      240

ataccactat ggccgatcac agagggccct ggggagccac ggaaggctct aggcagaggc      300

agggcctctt gggttagaag gacggcctgg agttgggatc ctgccacccg gcacttacca      360

gcagacaccc caccatgaga ttatgtctct tgatgattga gcaaataggc tcccaggtca      420

aatgtcc                                                                427


<210>  18
<211>  458
<212>  DNA
<213>  Homo sapiens

<400>  18
accctctccc tgctcagatg ctcccgcctc ccctgccttt atgccagggt gggtccgttc       60

cttggctggg cttccagggc atttcaggat ctgtccctct tgcctctgag ccccttgacc      120

gccgacccca ccgcagctct cagccctctg cctgccacgc cttccccttc ttccccagcc      180

cccgctgagt ccagcactgc cggcctggct cacctgcagg aagcctggta gctccttctc      240

catcagcacc ttgagctccc ccttggtcag ggtctgcgtg ctgccctcgc tgcccgaata      300

tcgggaaaag acgtctatga tcatgcccat ggctgtctct agttccgtca tggtgctaga      360

ttcagaccca ccttcctcct gggggctggc agggccgaga aaatgtccca ctggcagcct      420

cttggtgctt tataaggcag cctcatattg acacagag                              458


<210>  19
<211>  379
<212>  DNA
<213>  Homo sapiens

<400>  19
aaattctcat cctcccacta agggtagtgc ttttcagaca aagataccat ttaatagacc       60

tcgaggacac aacttttcat tgcagacaag tgctgttgtt ttgaaaaaca ctgcaggtgc      120

tacaaaggtc atagcagctc aggcacagca agctcacgtg caggcacctc agattggggc      180

gtggcgaaac agattgcatt tcctagaagg cccccagcga tgtggattga agcgcaagag      240

tgaggagttg gataatcata gcagcgcaat gcagattgtc gatgaattgt ccatacttcc      300

tgcaatgttg caaaccaaca tgggaaatcc agtgacagtt gtgacagcta ccacaggatc      360

aaaacagaat tgtaccact                                                   379


<210>  20
<211>  308
<212>  DNA
<213>  Homo sapiens

<400>  20
gtaaggagag tgatgaggaa aaaggggtgg ctgccctgct cggtgctgtt ctgtcaaaga       60

gccgaaattc ttcgcggggt ggcagatgag gacaggaaca gctggggtgt ggcaagtgtt      120

gctgcctggg gagagcggag ggtgaggtgt ttctcacggg tgcatccagt gactcatcag      180

gacagcggag ctcatgaggc catgtctccc gtttcctgcc ttagaatcac atgaaaatga      240

gcagagggtg ggtcatcagg acagggctct ccggggagcg gaagcgcctt caatgcaggc      300

ctgtgggc                                                               308


<210>  21
<211>  388
<212>  DNA
<213>  Homo sapiens

<400>  21
ctgctcaggt gaggacaggc ttctcatgag gtccctgaga aacttgcctt ttggagggaa       60

atgtcctctg ccctctggag cctggggaga aggttatttc tgcccgccag accagcatgc      120

tcgcttttct tccatgggca ttcaggaatc ctggccccat tctgacattc ctcaaatgga      180

ggaattcctc aaattaccag aggaaagtta ccaaagttta gatctgctgg agctcttcaa      240

ggattggcct gagacaagcc gggaggtgcc acggggcttg gagctggccc tgtgaggcac      300

ctccggggga agttcatgtc ctaggtggtt cacgtcatgg acctcttgga ggtccgtgaa      360

tagatttatt catgggattt gtgaattg                                         388


<210>  22
<211>  411
<212>  DNA
<213>  homo sapiens

<400>  22
tctcctcaca gtctgacaag aggtctaagg tttggtttta atttttttcc tccagccagg       60

acccttcaca acctgattgc taagcttgtt agcatagagg tggtctaacc gctacatgag      120

ccgctcaccc ctgacaacca cactgttgta atgtatcaga aatgttgatt actacaaaat      180

acagaaacac gggcactgtg gtgccccgaa ttgggaccgg tgattcactc acatgcagag      240

atttatttca gcactaatct ccctatgtag ttttgcttta cttgctgttg ttccaagggc      300

tgttatattc tttgccctcc actccatctc actcccatct ctccccactc acccctcttc      360

ccagccacct ccctcttctc caaagacttc attcaggccc ttaaggtgcc t               411


<210>  23
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  23
cccactggct gagaacacca tggtggggag agtgacttca tttttaactc tcctccctcc       60

tcctgtatac tcaaggacgg agtctcttct tggtgccatg gtgtttttag ctcctgccta      120

gtgcttctcc atgcctcttt ctaacaaaca gctgtaggcc tgggaagcag agcctctacc      180

aagtgtgaat ctctagctag aattttggcc tatggtttta acatttgcag tacattttct      240

tctagagcac attctactta ggggagggac accattttcc atttatgtta gtgacataaa      300

gcttccttta aaagataaat atattttggg atggagaatt gcttgaaccc aggaggcaga      360

ggtggcagtg agccgagacc gtgccattgc actccagcct gggtgacaga gcgagactcc      420

gtcttaaaaa ataaataaaa cagggtaaaa acacagaagt tacagaagcc tggcaggaaa      480

agccaaagac agaaggctga cggaggcttt aaacgcactt cgttgacatt caggaccctc      540

gggaatattc ctcggcccta cgggggtggg ggtgtgcttg ttcttatttt ggtctcacat      600

ccttctcagg ccagccttcc tcctcctgca tggccaagca gggtgagtcc ttccttggga      660

ggccgcctgt tctctccccg cctcctggtt ctggatttgg gtagggcagg atttgggtgt      720

tcaccctcct aggaggccct gagaggctgc caggccccag ctctgcttcc tccacccact      780

gatgctgggc tcagagaagg gtggggaagg tgctgttccc ccactgatgt cacacctgct      840

cgggggcctg gttgctgctg ggggtcccct ggtatgtgct cagtggggac tctgaccgga      900

gcctggacca tggagaggag cctcagcctg tctggccctt ccctccctcc ccatggagcc      960

ttggcatgtt ccacctcctc tgccctgcac acattcacca gtgagcccca cgcaggtggg     1020

taaggggttc tggagtgagt gggggtgctg                                      1050


<210>  24
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  24
ggcgctttga tctccacttc ccatggccaa cccccaacac accagatacg tactcactta       60

gtggagtttg gagcctgtgt ctgtcctcct agtgtgttgg ggtcgaccag agcgattggc      120

agggaccgtc agagacagag gtttaagcag gaagagagac actttcttct gaaagtagag      180

ccactgacag cttctatttt catagaccta aatatgggct tgccacccgg ataacattac      240

acgcatggcc tctcctggtg ctccccacac ccgggtgaag tccgtgttat tattatctcc      300

atttctcagg taagagaatt gggtgagaac tagagatgtt aagcagcaag ttcccacagg      360

gctgaaggag gtgagtggta gcgtcaagat gtgaaccact gttactgcac actgaatcat      420

accactatgg ccgatcacag agggccctgg ggagccacgg aaggctctag gcagaggcag      480

ggcctcttgg gttagaagga cggcctggag ttgggatcct gccacccggc acttaccagc      540

agacacccca ccatgagatt atgtctcttg atgattgagc aaataggctc ccaggtcaaa      600

tgtcccaggt ttgagtccca gcaagaaaaa agggaagagg agagagaggc agaggaaggg      660

gaaaaaaaag acagaaggaa ggagagggag aaggaggagt aggagggaag gagggaagcg      720

gggggaaaga aagatacgtg agataatatt caggtcaaat atggacagtt ttggctgggc      780

acggtggctc acgcctgtaa tcccagcact ttgggaggct gaggtgggag gatcacttaa      840

gcctgggagt tcaagaccag cctggacaac atagcaagcc gttgtctcta caaaaactat      900

aaaaactagc agggcatggt ggtgcatgcc tgtgatccca gctactgggg aggcagaggt      960

gagtggatca cttgagccca ggagttcaag atcagcctgg gcaacacagt gagatgaaag     1020

aaagaaagag agagagaaag agagagagag                                      1050


<210>  25
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  25
atggccggca gccttggagg acagccccga gggctcaagg gcttggcaag cttggcaaac       60

ttgcaaatgg cagccctgga ttgcattccg cccctgcccc cactgcacag gtttgagtcc      120

cactctccca ccaggcctgt cacaaataca ctggggtcaa ccccatgttt caaggatcaa      180

gctgaccaca ccctctccct gctcagatgc tcccgcctcc cctgccttta tgccagggtg      240

ggtccgttcc ttggctgggc ttccagggca tttcaggatc tgtccctctt gcctctgagc      300

cccttgaccg ccgaccccac cgcagctctc agccctctgc ctgccacgcc ttccccttct      360

tccccagccc ccgctgagtc cagcactgcc ggcctggctc acctgcagga agcctggtag      420

ctccttctcc atcagcacct tgagctcccc cttggtcagg gtctgcgtgc tgccctcgct      480

gcccgaatat cgggaaaaga cgtctatgat catgcccatg gctgtctcta gttccgtcat      540

ggtgctagat tcagacccac cttcctcctg ggggctggca gggccgagaa aatgtcccac      600

tggcagcctc ttggtgcttt ataaggcagc ctcatattga cacagagggt gggacagtgg      660

ggttgggaca ttcaggaagt cctgcccctc cccattcatg tgctcagttc tgatgaaatg      720

catcgttgtg atgacgtttc tggaaccttt cccccagcca aggcccaggg tgtgggctgc      780

ctccaggcat ccacatttta cagtgttcac ctgtgtctcg gcgccatcac tgagccacag      840

tggcatcctc attcctggcc ctccctgggt aagtgggcac ggggtgagtg tgtgtggagt      900

gagtggtgac tccgtggccc tttgtgtcaa tatcagagcg tgctggcacc cagcgtgctg      960

acacgaggag acatctgaga gtgaattcac atgggcgtgt ttgtgaacat ggatctgccc     1020

catcgtccct ttcttagagc actctgtgtc                                      1050


<210>  26
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  26
agggaaaaaa tcatcttcat ggaaattaat tactttttta caaattgtga atttgaccct       60

taagagtttt cttcctgata tttaaaattg aaaaaaaaat tgttgacatt aatatttctt      120

ctttcctttt ttttcttttc cttttttttt ttttttttgc aggtatggcc tcacaagtct      180

tggtctaccc accatatgtt tatcaaactc agtcaagtgc cttttgtagt gtgaagaaac      240

tcaaagtaga gccaagcagt tgtgtattcc aggaaagaaa ctatccacgg acctatgtga      300

atggtagaaa ctttggaaat tctcatcctc ccactaaggg tagtgctttt cagacaaaga      360

taccatttaa tagacctcga ggacacaact tttcattgca gacaagtgct gttgttttga      420

aaaacactgc aggtgctaca aaggtcatag cagctcaggc acagcaagct cacgtgcagg      480

cacctcagat tggggcgtgg cgaaacagat tgcatttcct agaaggcccc cagcgatgtg      540

gattgaagcg caagagtgag gagttggata atcatagcag cgcaatgcag attgtcgatg      600

aattgtccat acttcctgca atgttgcaaa ccaacatggg aaatccagtg acagttgtga      660

cagctaccac aggatcaaaa cagaattgta ccactggaga aggtgactat cagttagtac      720

agcatgaagt cttatgctcc atgaaaaata cttacgaagt ccttgatttt cttggtcgag      780

gcacgtttgg ccaggtagtt aaatgctgga aaagagggac aaatgaaatt gtagcaatca      840

aaattttgaa gaatcatcct tcttatgccc gtcaaggtca aatagaagtg agcatattag      900

caaggctcag tactgaaaat gctgatgaat ataactttgt acgagcttat gaatgctttc      960

agcaccgtaa ccatacttgt ttagtctttg agatgctgga acaaaacttg tatgactttc     1020

tgaaacaaaa taaatttagt cccctgccac                                      1050


<210>  27
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  27
ctgaatcttg aataggagct tgtccataga gggtcacgga tctcccacac agagagcacc       60

acaaaatcct cagcaatttg gtgagagtat ggtacaagat gatagtggcc tggggcttga      120

acaagaggct gagtgcggtg gctcacacct gtaatctcag cactttggga ggctgaggcg      180

aacacctgag gtcagcagtt cgagaccagc ctggccaaaa tggcaaaacc ccgtctctat      240

taaaaataca aacattagcc gggcatggtg gcaggtgcct gtaatcccag ctactcagga      300

ggctgaggtg ggaggattgc ttgagtgtgg gaggcggagg ttgcagtgag ccgagatcat      360

gccactgcac tccagcctgg gtgacagagt gagaccctgt ctcaaaaaaa aaaaaaaaaa      420

aaagttagac gtctagtaca ggaaccatgc aacacatcga gtcagccaag ggcaaggtaa      480

ggagagtgat gaggaaaaag gggtggctgc cctgctcggt gctgttctgt caaagagccg      540

aaattcttcg cggggtggca gatgaggaca ggaacagctg gggtgtggca agtgttgctg      600

cctggggaga gcggagggtg aggtgtttct cacgggtgca tccagtgact catcaggaca      660

gcggagctca tgaggccatg tctcccgttt cctgccttag aatcacatga aaatgagcag      720

agggtgggtc atcaggacag ggctctccgg ggagcggaag cgccttcaat gcaggcctgt      780

gggcaggggc gtgggggcgc gcacacacac acgcctgggt gacctctacg tatatacaga      840

gcctccctgg ccctcctgga aagagtcctg gaaagacaac cttcaggtcc agccctggag      900

ctggaggagt ggagccccac tctgaagacg cagcctttct ccaggttctg tctctcccat      960

tctgattctt gacaccagat gcaggtaagc agagatgaaa gggtgaggtg acggccaggg     1020

aacagcctag cctcacagat gagagtgcac                                      1050


<210>  28
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  28
aaactggaga gatagggttt taacaagatg caaggacaat ctgaggactg agagccattt       60

caacgtgagc ccccagtctg agaacaagaa agaagaactt ctgtctcgag gtaaaaaggc      120

ctgctgggga cctggggtcc aggtgaaggg atgggatggt tgacagaact gctcaggtga      180

ggacaggctt ctcatgaggt ccctgagaaa cttgcctttt ggagggaaat gtcctctgcc      240

ctctggagcc tggggagaag gttatttctg cccgccagac cagcatgctc gcttttcttc      300

catgggcatt caggaatcct ggccccattc tgacattcct caaatggagg aattcctcaa      360

attaccagag gaaagttacc aaagtttaga tctgctggag ctcttcaagg attggcctga      420

gacaagccgg gaggtgccac ggggcttgga gctggccctg tgaggcacct ccgggggaag      480

ttcatgtcct aggtggttca cgtcatggac ctcttggagg tccgtgaata gatttattca      540

tgggatttgt gaattggggg gaaaaataca tctttatttt cactaatctt taattgaaag      600

tcagcacttg cttcagttat gaatgtagac aatgaaccac aatagaattt gccatcaata      660

gaaaacacaa atattttcaa atctcattac agtttttata gatttctcca aatgtcctta      720

acgctcagca ctactacaga attacaacag ttattaggct gatgtcaaat ctaaagaagc      780

atgtgtactg ctctaccaca cattcttcta atgttttgac aactgtcttg tcataatttg      840

ttccctttat tatcccatgt atcttattaa tttttaaatg ttgttctgag aagggactcc      900

atatgccttc ccagaccacc aaagaggtcc atggcgcctt tatgtcaggc acctgctttg      960

gtgtgttgag caggaagcct gagatctcag acaagagctt caagggcccc ccagcccaaa     1020

cctctgtcta ctaacaagtc tggttctact                                      1050


<210>  29
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  29
cagtacaaag tagacgcacg cacacacgct cacacacaca cagaggcagg caggcaggca       60

ggctgaacac gctggctggg aactgctgtc ggagccctct atagcaggag aggagaggga      120

gaggagagga gggagggaaa gagggaggga gggagggagc acgggagagg agggagaggg      180

agagagcagg agctccagag agggagggag gttggtatgg aggaagggag ggaagaaggg      240

agggagggag ggagggagga gggagggagg gagggggaga gagagagaga gagagagaga      300

gagagagaga gagagagaga gagagagaga gagagagaga ggagctggat agctttaggc      360

accactgctt gtttttaaag aagcagtttg tggagaggtc atttcctgtc cacattgtag      420

actagttcac aaatataatt ctcctcacag tctgacaaga ggtctaaggt ttggttttaa      480

tttttttcct ccagccagga cccttcacaa cctgattgct aagcttgtta gcatagaggt      540

ggtctaaccg ctacatgagc cgctcacccc tgacaaccac actgttgtaa tgtatcagaa      600

atgttgatta ctacaaaata cagaaacacg ggcactgtgg tgccccgaat tgggaccggt      660

gattcactca catgcagaga tttatttcag cactaatctc cctatgtagt tttgctttac      720

ttgctgttgt tccaagggct gttatattct ttgccctcca ctccatctca ctcccatctc      780

tccccactca cccctcttcc cagccacctc cctcttctcc aaagacttca ttcaggccct      840

taaggtgcct gggcattttc aggtaaaaac agtcgttctg aatgtggaag gtataaaata      900

cacttaagga gagcaatggt cttttttccc aggaaggaaa aacaaacaaa caaacaaaca      960

aaaaacccaa acagacctcc caataagaca ggaaaagcaa agaaggagaa aactgccaca     1020

aaaatgacca cggaaaattt ggttgagaag                                      1050




