                         SEQUENCE LISTING

<110>  Van Voorhis, Wesley
       Hol, Wilhelmus
       Larson, Eric
       Maly, Dustin James
       Merritt, Ethan
       Ojo, Kayode
 
<120>  COMPOSITIONS AND METHODS FOR TREATING TOXOPLASMOSIS, 
       CRYPTOSPORIDIOSIS AND OTHER APICOMPLEXAN PROTOZOAN RELATED 
       DISEASES

<130>  10-1391-PCT

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Toxoplasma gondii

<400>  1

Gly Tyr Phe Tyr Leu Val Gly Glu Val Tyr Thr Gly Gly Glu Leu Phe 
1               5                   10                  15      


Asp Glu Ile 
            


<210>  2
<211>  19
<212>  PRT
<213>  Cryptosporidium parvum

<400>  2

Ser Ser Phe Tyr Ile Val Gly Glu Leu Tyr Thr Gly Gly Glu Leu Phe 
1               5                   10                  15      


Asp Glu Ile 
            


<210>  3
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ggctacttct acctcgtcat ggaagtgtac acgggaggcg agttg                       45


<210>  4
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
caactcgcct cccgtgtaca cttccatgac gaggtagaag tagcc                       45


<210>  5
<211>  19
<212>  PRT
<213>  Toxoplasma gondii

<400>  5

Arg Asn Tyr Tyr Leu Val Met Glu Val Tyr Arg Gly Gly Glu Leu Phe 
1               5                   10                  15      


Asp Glu Ile 
            


<210>  6
<211>  19
<212>  PRT
<213>  Eimeria tenella

<400>  6

Gly Tyr Phe Tyr Leu Val Thr Glu Val Tyr Thr Gly Gly Glu Leu Phe 
1               5                   10                  15      


Asp Glu Ile 
            


<210>  7
<211>  19
<212>  PRT
<213>  Plasmodium falciparum

<400>  7

Lys Tyr Phe Tyr Leu Val Thr Glu Phe Tyr Glu Gly Gly Glu Leu Phe 
1               5                   10                  15      


Glu Gln Ile 
            


<210>  8
<211>  19
<212>  PRT
<213>  Plasmodium falciparum

<400>  8

Asn Tyr Tyr Tyr Leu Val Ser Asp Val Thr Thr Gly Gly Glu Leu Phe 
1               5                   10                  15      


Asp Glu Ile 
            


<210>  9
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly His Leu Tyr Leu Ile Met Gln Leu Val Ser Gly Gly Glu Leu Phe 
1               5                   10                  15      


Asp Arg Ile 
            


<210>  10
<211>  19
<212>  PRT
<213>  Xenopus tropicalis

<400>  10

Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly Glu Leu Phe 
1               5                   10                  15      


Glu Asp Ile 
            


<210>  11
<211>  19
<212>  PRT
<213>  Macaca mulatta

<400>  11

Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly Glu Leu Phe 
1               5                   10                  15      


Glu Asp Ile 
            


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Pro Leu Ala Arg Thr Leu Ser Val Ala Gly Leu Pro Gly Lys Lys 
1               5                   10                  15  


<210>  13
<211>  507
<212>  PRT
<213>  Toxoplasma gondii

<400>  13

Met Gly Gln Gln Glu Ser Thr Leu Gly Gly Ala Ala Gly Glu Pro Arg 
1               5                   10                  15      


Ser Arg Gly His Ala Ala Gly Thr Ser Gly Gly Pro Gly Asp His Leu 
            20                  25                  30          


His Ala Thr Pro Gly Met Phe Val Gln His Ser Thr Ala Ile Phe Ser 
        35                  40                  45              


Asp Arg Tyr Lys Gly Gln Arg Val Leu Gly Lys Gly Ser Phe Gly Glu 
    50                  55                  60                  


Val Ile Leu Cys Lys Asp Lys Ile Thr Gly Gln Glu Cys Ala Val Lys 
65                  70                  75                  80  


Val Ile Ser Lys Arg Gln Val Lys Gln Lys Thr Asp Lys Glu Ser Leu 
                85                  90                  95      


Leu Arg Glu Val Gln Leu Leu Lys Gln Leu Asp His Pro Asn Ile Met 
            100                 105                 110         


Lys Leu Tyr Glu Phe Phe Glu Asp Lys Gly Tyr Phe Tyr Leu Val Gly 
        115                 120                 125             


Glu Val Tyr Thr Gly Gly Glu Leu Phe Asp Glu Ile Ile Ser Arg Lys 
    130                 135                 140                 


Arg Phe Ser Glu Val Asp Ala Ala Arg Ile Ile Arg Gln Val Leu Ser 
145                 150                 155                 160 


Gly Ile Thr Tyr Met His Lys Asn Lys Ile Val His Arg Asp Leu Lys 
                165                 170                 175     


Pro Glu Asn Leu Leu Leu Glu Ser Lys Ser Lys Asp Ala Asn Ile Arg 
            180                 185                 190         


Ile Ile Asp Phe Gly Leu Ser Thr His Phe Glu Ala Ser Lys Lys Met 
        195                 200                 205             


Lys Asp Lys Ile Gly Thr Ala Tyr Tyr Ile Ala Pro Glu Val Leu His 
    210                 215                 220                 


Gly Thr Tyr Asp Glu Lys Cys Asp Val Trp Ser Thr Gly Val Ile Leu 
225                 230                 235                 240 


Tyr Ile Leu Leu Ser Gly Cys Pro Pro Phe Asn Gly Ala Asn Glu Tyr 
                245                 250                 255     


Asp Ile Leu Lys Lys Val Glu Lys Gly Lys Tyr Thr Phe Glu Leu Pro 
            260                 265                 270         


Gln Trp Lys Lys Val Ser Glu Ser Ala Lys Asp Leu Ile Arg Lys Met 
        275                 280                 285             


Leu Thr Tyr Val Pro Ser Met Arg Ile Ser Ala Arg Asp Ala Leu Asp 
    290                 295                 300                 


His Glu Trp Ile Gln Thr Tyr Thr Lys Glu Gln Ile Ser Val Asp Val 
305                 310                 315                 320 


Pro Ser Leu Asp Asn Ala Ile Leu Asn Ile Arg Gln Phe Gln Gly Thr 
                325                 330                 335     


Gln Lys Leu Ala Gln Ala Ala Leu Leu Tyr Met Gly Ser Lys Leu Thr 
            340                 345                 350         


Ser Gln Asp Glu Thr Lys Glu Leu Thr Ala Ile Phe His Lys Met Asp 
        355                 360                 365             


Lys Asn Gly Asp Gly Gln Leu Asp Arg Ala Glu Leu Ile Glu Gly Tyr 
    370                 375                 380                 


Lys Glu Leu Met Arg Met Lys Gly Gln Asp Ala Ser Met Leu Asp Ala 
385                 390                 395                 400 


Ser Ala Val Glu His Glu Val Asp Gln Val Leu Asp Ala Val Asp Phe 
                405                 410                 415     


Asp Lys Asn Gly Tyr Ile Glu Tyr Ser Glu Phe Val Thr Val Ala Met 
            420                 425                 430         


Asp Arg Lys Thr Leu Leu Ser Arg Glu Arg Leu Glu Arg Ala Phe Arg 
        435                 440                 445             


Met Phe Asp Ser Asp Asn Ser Gly Lys Ile Ser Ser Thr Glu Leu Ala 
    450                 455                 460                 


Thr Ile Phe Gly Val Ser Asp Val Asp Ser Glu Thr Trp Lys Ser Val 
465                 470                 475                 480 


Leu Ser Glu Val Asp Lys Asn Asn Asp Gly Glu Val Asp Phe Asp Glu 
                485                 490                 495     


Phe Gln Gln Met Leu Leu Lys Leu Cys Gly Asn 
            500                 505         


<210>  14
<211>  538
<212>  PRT
<213>  Cryptosporidium parvum

<400>  14

Met Gly Asn Thr Ala Val Gly Asn Thr Gly Thr Arg Leu Arg Ala Pro 
1               5                   10                  15      


Val Asp Ala Val Val Asn Thr Thr Asn Lys Lys Ala Pro Val Ser Glu 
            20                  25                  30          


Lys Pro Ser Gln Pro Gln Ile Pro Asn Lys Thr Ser Asp Val Lys Lys 
        35                  40                  45              


Gly Gly Thr Met Gly Gly Glu Arg Gly Ser Val Thr Thr Gly Met Phe 
    50                  55                  60                  


Val Gln Ser Gly Ser Gly Thr Phe Ala Glu Arg Tyr Asn Ile Val Cys 
65                  70                  75                  80  


Met Leu Gly Lys Gly Ser Phe Gly Glu Val Leu Lys Cys Lys Asp Arg 
                85                  90                  95      


Ile Thr Gln Gln Glu Tyr Ala Val Lys Val Ile Asn Lys Ala Ser Ala 
            100                 105                 110         


Lys Asn Lys Asp Thr Ser Thr Ile Leu Arg Glu Val Glu Leu Leu Lys 
        115                 120                 125             


Lys Leu Asp His Pro Asn Ile Met Lys Leu Phe Glu Ile Leu Glu Asp 
    130                 135                 140                 


Ser Ser Ser Phe Tyr Ile Val Gly Glu Leu Tyr Thr Gly Gly Glu Leu 
145                 150                 155                 160 


Phe Asp Glu Ile Ile Lys Arg Lys Arg Phe Ser Glu His Asp Ala Ala 
                165                 170                 175     


Arg Ile Ile Lys Gln Val Phe Ser Gly Ile Thr Tyr Met His Lys His 
            180                 185                 190         


Asn Ile Val His Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Glu Ser 
        195                 200                 205             


Lys Glu Lys Asp Cys Asp Ile Lys Ile Ile Asp Phe Gly Leu Ser Thr 
    210                 215                 220                 


Cys Phe Gln Gln Asn Thr Lys Met Lys Asp Arg Ile Gly Thr Ala Tyr 
225                 230                 235                 240 


Tyr Ile Ala Pro Glu Val Leu Arg Gly Thr Tyr Asp Glu Lys Cys Asp 
                245                 250                 255     


Val Trp Ser Ala Gly Val Ile Leu Tyr Ile Leu Leu Ser Gly Thr Pro 
            260                 265                 270         


Pro Phe Tyr Gly Lys Asn Glu Tyr Asp Ile Leu Lys Arg Val Glu Thr 
        275                 280                 285             


Gly Lys Tyr Ala Phe Asp Leu Pro Gln Trp Arg Thr Ile Ser Asp Asp 
    290                 295                 300                 


Ala Lys Asp Leu Ile Arg Lys Met Leu Thr Phe His Pro Ser Leu Arg 
305                 310                 315                 320 


Ile Thr Ala Thr Gln Cys Leu Glu His Pro Trp Ile Gln Lys Tyr Ser 
                325                 330                 335     


Ser Glu Thr Pro Thr Ile Ser Asp Leu Pro Ser Leu Glu Ser Ala Met 
            340                 345                 350         


Thr Asn Ile Arg Gln Phe Gln Ala Glu Lys Lys Leu Ala Gln Ala Ala 
        355                 360                 365             


Leu Leu Tyr Met Ala Ser Lys Leu Thr Thr Leu Asp Glu Thr Lys Gln 
    370                 375                 380                 


Leu Thr Glu Ile Phe Arg Lys Leu Asp Thr Asn Asn Asp Gly Met Leu 
385                 390                 395                 400 


Asp Arg Asp Glu Leu Val Arg Gly Tyr His Glu Phe Met Arg Leu Lys 
                405                 410                 415     


Gly Val Asp Ser Asn Ser Leu Ile Gln Asn Glu Gly Ser Thr Ile Glu 
            420                 425                 430         


Asp Gln Ile Asp Ser Leu Met Pro Leu Leu Asp Met Asp Gly Ser Gly 
        435                 440                 445             


Ser Ile Glu Tyr Ser Glu Phe Ile Ala Ser Ala Ile Asp Arg Thr Ile 
    450                 455                 460                 


Leu Leu Ser Arg Glu Arg Met Glu Arg Ala Phe Lys Met Phe Asp Lys 
465                 470                 475                 480 


Asp Gly Ser Gly Lys Ile Ser Thr Lys Glu Leu Phe Lys Leu Phe Ser 
                485                 490                 495     


Gln Ala Asp Ser Ser Ile Gln Met Glu Glu Leu Glu Ser Ile Ile Glu 
            500                 505                 510         


Gln Val Asp Asn Asn Lys Asp Gly Glu Val Asp Phe Asn Glu Phe Val 
        515                 520                 525             


Glu Met Leu Gln Asn Phe Val Arg Asn Glu 
    530                 535             


<210>  15
<211>  1617
<212>  DNA
<213>  Cryptosporidium parvum

<400>  15
atgggaaata ctgcagtagg gaatacagga acaaggctta gagcaccagt agatgccgta       60

gtaaacacta ctaataagaa agcacctgta agtgaaaagc catctcaacc acaaatacca      120

aacaaaactt ctgatgttaa aaagggagga actatgggag gagagagagg aagtgtaaca      180

actggtatgt ttgttcagag tggtagcggg acctttgcag aaaggtacaa tattgtatgt      240

atgcttggca aaggttcttt tggagaagtt ttgaaatgta aagacagaat cactcaacaa      300

gaatatgctg tcaaggttat taacaaagct agtgcaaaga acaaggatac tagtacaatt      360

ttgagagaag ttgagctttt aaagaagctt gatcatccaa atattatgaa gctattcgag      420

attttggaag attcatctag cttctacatt gtaggagagc tttacacagg aggagaactc      480

tttgatgaaa ttattaagag aaaaagattt agtgagcatg atgctgctag aattattaaa      540

caagtatttt caggaattac ttacatgcat aaacataaca ttgtacatag agatttaaag      600

ccagaaaaca tacttttaga gtctaaagaa aaagactgtg atattaaaat tatagatttt      660

ggattatcaa catgcttcca gcaaaatacc aagatgaagg atagaatagg aacagcctac      720

tatatagctc cagaagtttt gagaggtact tatgatgaga aatgtgatgt atggtcagct      780

ggagtaattc tatatattct cttatctgga acacctccat tctatggaaa aaatgaatat      840

gatattttga agagagtcga gacaggaaag tatgcttttg accttccaca atggagaact      900

atttctgatg atgccaagga tttaataaga aagatgttaa ctttccatcc ttctttgaga      960

attactgcaa cacaatgttt agaacatcca tggattcaaa aatattcaag tgagactcca     1020

acaattagtg acttaccttc attagaatct gctatgacaa atattcgtca attccaagca     1080

gaaaagaaac ttgctcaagc agctctacta tatatggcaa gtaaattgac aacattggac     1140

gaaacaaagc aacttacaga gatctttagg aagttagata ctaataatga tggtatgtta     1200

gatagagatg agctcgttcg tggttatcat gaatttatga gattgaaagg agtagattct     1260

aattctttaa ttcagaatga aggatcaaca atagaggatc aaattgatag cttaatgcca     1320

ttgttagata tggatggatc gggttctata gaatattcag aatttattgc atctgcaata     1380

gatagaacaa ttttgttgag tagagaaaga atggaaagag cttttaaaat gtttgataaa     1440

gatggttctg gtaagatttc tacaaaggaa ctttttaaac tcttttccca ggcagatagc     1500

agtattcaga tggaggagtt ggaatcaata attgaacaag ttgacaacaa taaggatggg     1560

gaagtagact ttaatgagtt tgtagaaatg cttcagaatt ttgtcaggaa tgaataa        1617


<210>  16
<211>  1617
<212>  DNA
<213>  Cryptosporidium parvum

<400>  16
atgggaaata ctgcagtagg gaatacagga acaaggctta gagcaccagt agatgccgta       60

gtaaacacta ctaataagaa agcacctgta agtgaaaagc catctcaacc acaaatacca      120

aacaaaactt ctgatgttaa aaagggagga actatgggag gagagagagg aagtgtaaca      180

actggtatgt ttgttcagag tggtagcggg acctttgcag aaaggtacaa tattgtatgt      240

atgcttggca aaggttcttt tggagaagtt ttgaaatgta aagacagaat cactcaacaa      300

gaatatgctg tcaaggttat taacaaagct agtgcaaaga acaaggatac tagtacaatt      360

ttgagagaag ttgagctttt aaagaagctt gatcatccaa atattatgaa gctattcgag      420

attttggaag attcatctag cttctacatt gtaggagagc tttacacagg aggagaactc      480

tttgatgaaa ttattaagag aaaaagattt agtgagcatg atgctgctag aattattaaa      540

caagtatttt caggaattac ttacatgcat aaacataaca ttgtacatag agatttaaag      600

ccagaaaaca tacttttaga gtctaaagaa aaagactgtg atattaaaat tatagatttt      660

ggattatcaa catgcttcca gcaaaatacc aagatgaagg atagaatagg aacagcctac      720

tatatagctc cagaagtttt gagaggtact tatgatgaga aatgtgatgt atggtcagct      780

ggagtaattc tatatattct cttatctgga acacctccat tctatggaaa aaatgaatat      840

gatattttga agagagtcga gacaggaaag tatgcttttg accttccaca atggagaact      900

atttctgatg atgccaagga tttaataaga aagatgttaa ctttccatcc ttctttgaga      960

attactgcaa cacaatgttt agaacatcca tggattcaaa aatattcaag tgagactcca     1020

acaattagtg acttaccttc attagaatct gctatgacaa atattcgtca attccaagca     1080

gaaaagaaac ttgctcaagc agctctacta tatatggcaa gtaaattgac aacattggac     1140

gaaacaaagc aacttacaga gatctttagg aagttagata ctaataatga tggtatgtta     1200

gatagagatg agctcgttcg tggttatcat gaatttatga gattgaaagg agtagattct     1260

aattctttaa ttcagaatga aggatcaaca atagaggatc aaattgatag cttaatgcca     1320

ttgttagata tggatggatc gggttctata gaatattcag aatttattgc atctgcaata     1380

gatagaacaa ttttgttgag tagagaaaga atggaaagag cttttaaaat gtttgataaa     1440

gatggttctg gtaagatttc tacaaaggaa ctttttaaac tcttttccca ggcagatagc     1500

agtattcaga tggaggagtt ggaatcaata attgaacaag ttgacaacaa taaggatggg     1560

gaagtagact ttaatgagtt tgtagaaatg cttcagaatt ttgtcaggaa tgaataa        1617


<210>  17
<211>  1617
<212>  DNA
<213>  Cryptosporidium parvum

<400>  17
atgggaaata ctgcagtagg gaatacagga acaaggctta gagcaccagt agatgccgta       60

gtaaacacta ctaataagaa agcacctgta agtgaaaagc catctcaacc acaaatacca      120

aacaaaactt ctgatgttaa aaagggagga actatgggag gagagagagg aagtgtaaca      180

actggtatgt ttgttcagag tggtagcggg acctttgcag aaaggtacaa tattgtatgt      240

atgcttggca aaggttcttt tggagaagtt ttgaaatgta aagacagaat cactcaacaa      300

gaatatgctg tcaaggttat taacaaagct agtgcaaaga acaaggatac tagtacaatt      360

ttgagagaag ttgagctttt aaagaagctt gatcatccaa atattatgaa gctattcgag      420

attttggaag attcatctag cttctacatt gtaggagagc tttacacagg aggagaactc      480

tttgatgaaa ttattaagag aaaaagattt agtgagcatg atgctgctag aattattaaa      540

caagtatttt caggaattac ttacatgcat aaacataaca ttgtacatag agatttaaag      600

ccagaaaaca tacttttaga gtctaaagaa aaagactgtg atattaaaat tatagatttt      660

ggattatcaa catgcttcca gcaaaatacc aagatgaagg atagaatagg aacagcctac      720

tatatagctc cagaagtttt gagaggtact tatgatgaga aatgtgatgt atggtcagct      780

ggagtaattc tatatattct cttatctgga acacctccat tctatggaaa aaatgaatat      840

gatattttga agagagtcga gacaggaaag tatgcttttg accttccaca atggagaact      900

atttctgatg atgccaagga tttaataaga aagatgttaa ctttccatcc ttctttgaga      960

attactgcaa cacaatgttt agaacatcca tggattcaaa aatattcaag tgagactcca     1020

acaattagtg acttaccttc attagaatct gctatgacaa atattcgtca attccaagca     1080

gaaaagaaac ttgctcaagc agctctacta tatatggcaa gtaaattgac aacattggac     1140

gaaacaaagc aacttacaga gatctttagg aagttagata ctaataatga tggtatgtta     1200

gatagagatg agctcgttcg tggttatcat gaatttatga gattgaaagg agtagattct     1260

aattctttaa ttcagaatga aggatcaaca atagaggatc aaattgatag cttaatgcca     1320

ttgttagata tggatggatc gggttctata gaatattcag aatttattgc atctgcaata     1380

gatagaacaa ttttgttgag tagagaaaga atggaaagag cttttaaaat gtttgataaa     1440

gatggttctg gtaagatttc tacaaaggaa ctttttaaac tcttttccca ggcagatagc     1500

agtattcaga tggaggagtt ggaatcaata attgaacaag ttgacaacaa taaggatggg     1560

gaagtagact ttaatgagtt tgtagaaatg cttcagaatt ttgtcaggaa tgaataa        1617


