                         SEQUENCE LISTING

<110>  Baylor Research Institute
       Shimoda, Masayuki
       Chen, Shuyuan
       Noguchi, Hirofumi
       Matsumoto, Shinichi
       Grayburn, Paul A.
 
<120>  IN-VIVO NON-VIRAL GENE DELIVERY OF HUMAN VASCULAR ENDOTHELIAL 
       GROWTH FACTOR FOLLOWING ISLET TRANSPLANTATION

<130>  BHCS:2428

<140>  Concurrently Herewith
<141>  2011-01-18

<150>  61/298,824
<151>  2010-01-27

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  1
ttcctcgaga atgaactttc tgctgctgtc ttg                                    33


<210>  2
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  2
aaacccgggt caccgcctcg gcttgtca                                          28


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  3
cccttcattg acctcaacta catg                                              24


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  4
ttccattgat gacaagcttc cc                                                22


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  5
aaggaggagg gcagaatcat                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  6
atctgcatgg tgatgttgga                                                   20


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  7
acgacagaag gagagcagaa gt                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  8
catggtgatg ttgctctctg ac                                                22


<210>  9
<211>  3392
<212>  DNA
<213>  Homo sapiens

<400>  9
tcgcggaggc ttggggcagc cgggtagctc ggaggtcgtg gcgctggggg ctagcaccag       60

cgctctgtcg ggaggcgcag cggttaggtg gaccggtcag cggactcacc ggccagggcg      120

ctcggtgctg gaatttgata ttcattgatc cgggttttat ccctcttctt ttttcttaaa      180

catttttttt taaaactgta ttgtttctcg ttttaattta tttttgcttg ccattcccca      240

cttgaatcgg gccgacggct tggggagatt gctctacttc cccaaatcac tgtggatttt      300

ggaaaccagc agaaagagga aagaggtagc aagagctcca gagagaagtc gaggaagaga      360

gagacggggt cagagagagc gcgcgggcgt gcgagcagcg aaagcgacag gggcaaagtg      420

agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc cttgggatcc      480

cgcagctgac cagtcgcgct gacggacaga cagacagaca ccgcccccag ccccagctac      540

cacctcctcc ccggccggcg gcggacagtg gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg ggtggagggg gtcggggctc gcggcgtcgc actgaaactt      660

ttcgtccaac ttctgggctg ttctcgcttc ggaggagccg tggtccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagtgctagc tcgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc agtggcgact cggcgctcgg      840

aagccgggct catggacggg tgaggcggcg gtgtgcgcag acagtgctcc agccgcgcgc      900

gctccccagg ccctggcccg ggcctcgggc cggggaggaa gagtagctcg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggtcgggcct ccgaaaccat gaactttctg ctgtcttggg tgcattggag ccttgccttg     1080

ctgctctacc tccaccatgc caagtggtcc caggctgcac ccatggcaga aggaggaggg     1140

cagaatcatc acgaagtggt gaagttcatg gatgtctatc agcgcagcta ctgccatcca     1200

atcgagaccc tggtggacat cttccaggag taccctgatg agatcgagta catcttcaag     1260

ccatcctgtg tgcccctgat gcgatgcggg ggctgctgca atgacgaggg cctggagtgt     1320

gtgcccactg aggagtccaa catcaccatg cagattatgc ggatcaaacc tcaccaaggc     1380

cagcacatag gagagatgag cttcctacag cacaacaaat gtgaatgcag atgtgacaag     1440

ccgaggcggt gagccgggca ggaggaagga gcctccctca gggtttcggg aaccagatct     1500

ctcaccagga aagactgata cagaacgatc gatacagaaa ccacgctgcc gccaccacac     1560

catcaccatc gacagaacag tccttaatcc agaaacctga aatgaaggaa gaggagactc     1620

tgcgcagagc actttgggtc cggagggcga gactccggcg gaagcattcc cgggcgggtg     1680

acccagcacg gtccctcttg gaattggatt cgccatttta tttttcttgc tgctaaatca     1740

ccgagcccgg aagattagag agttttattt ctgggattcc tgtagacaca cccacccaca     1800

tacatacatt tatatatata tatattatat atatataaaa ataaatatct ctattttata     1860

tatataaaat atatatattc tttttttaaa ttaacagtgc taatgttatt ggtgtcttca     1920

ctggatgtat ttgactgctg tggacttgag ttgggagggg aatgttccca ctcagatcct     1980

gacagggaag aggaggagat gagagactct ggcatgatct tttttttgtc ccacttggtg     2040

gggccagggt cctctcccct gcccaggaat gtgcaaggcc agggcatggg ggcaaatatg     2100

acccagtttt gggaacaccg acaaacccag ccctggcgct gagcctctct accccaggtc     2160

agacggacag aaagacagat cacaggtaca gggatgagga caccggctct gaccaggagt     2220

ttggggagct tcaggacatt gctgtgcttt ggggattccc tccacatgct gcacgcgcat     2280

ctcgccccca ggggcactgc ctggaagatt caggagcctg ggcggccttc gcttactctc     2340

acctgcttct gagttgccca ggagaccact ggcagatgtc ccggcgaaga gaagagacac     2400

attgttggaa gaagcagccc atgacagctc cccttcctgg gactcgccct catcctcttc     2460

ctgctcccct tcctggggtg cagcctaaaa ggacctatgt cctcacacca ttgaaaccac     2520

tagttctgtc cccccaggag acctggttgt gtgtgtgtga gtggttgacc ttcctccatc     2580

ccctggtcct tcccttccct tcccgaggca cagagagaca gggcaggatc cacgtgccca     2640

ttgtggaggc agagaaaaga gaaagtgttt tatatacggt acttatttaa tatccctttt     2700

taattagaaa ttaaaacagt taatttaatt aaagagtagg gttttttttc agtattcttg     2760

gttaatattt aatttcaact atttatgaga tgtatctttt gctctctctt gctctcttat     2820

ttgtaccggt ttttgtatat aaaattcatg tttccaatct ctctctccct gatcggtgac     2880

agtcactagc ttatcttgaa cagatattta attttgctaa cactcagctc tgccctcccc     2940

gatcccctgg ctccccagca cacattcctt tgaaataagg tttcaatata catctacata     3000

ctatatatat atttggcaac ttgtatttgt gtgtatatat atatatatat gtttatgtat     3060

atatgtgatt ctgataaaat agacattgct attctgtttt ttatatgtaa aaacaaaaca     3120

agaaaaaata gagaattcta catactaaat ctctctcctt ttttaatttt aatatttgtt     3180

atcatttatt tattggtgct actgtttatc cgtaataatt gtggggaaaa gatattaaca     3240

tcacgtcttt gtctctagtg cagtttttcg agatattccg tagtacatat ttatttttaa     3300

acaacgacaa agaaatacag atatatctta aaaaaaaaaa agcattttgt attaaagaat     3360

ttaattctga tctcaaaaaa aaaaaaaaaa aa                                   3392


<210>  10
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys 
        355                 360                 365             


Pro Arg Arg 
    370     


<210>  11
<211>  714
<212>  DNA
<213>  Aequorea victoria

<400>  11
atgagtaaag gagaagaact tttcactgga gtggtcccag ttcttgttga attagatggc       60

gatgttaatg ggcaaaaatt ctctgtcagt ggagagggtg aaggtgatgc aacatacgga      120

aaacttaccc ttaattttat ttgcactact gggaagctac ctgttccatg gccaacactt      180

gtcactactt tctcttatgg tgttcaatgc ttctcaagat acccagatca tatgaaacag      240

catgactttt tcaagagtgc catgcccgaa ggttatgtac aggaaagaac tatattttac      300

aaagatgacg ggaactacaa gacacgtgct gaagtcaagt ttgaaggtga tacccttgtt      360

aatagaatcg agttaaaagg tattgatttt aaagaagatg gaaacattct tggacacaaa      420

atggaataca actataactc acataatgta tacatcatgg gagacaaacc aaagaatggc      480

atcaaagtta acttcaaaat tagacacaac attaaagatg gaagcgttca attagcagac      540

cattatcaac aaaatactcc aattggcgat ggccctgtcc ttttaccaga caaccattac      600

ctgtccacac aatctgccct ttccaaagat cccaacgaaa agagagatca catgatcctt      660

cttgagtttg taacagctgc taggattaca catggcatgg atgaactata caaa            714


<210>  12
<211>  238
<212>  PRT
<213>  Aequorea victoria

<400>  12

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Val Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly Gln Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Asn Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Tyr Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Met Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Gly Asp Lys Pro Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Lys Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Arg Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


