                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
 
<120>  BIOMARKERS FOR CIRCULATING TUMOR CELLS

<130>  028193-9082 WO00

<140>  New International Application
<141>  2010-09-24

<150>  61/298,845
<151>  2010-01-27

<150>  61/308,780
<151>  2010-02-26

<150>  61/309,131
<151>  2010-03-01

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  4321
<212>  DNA
<213>  Mus musculus

<400>  1
cacacacaca cgcacacaca cacacacaca cacttctcgg cgcgcacgac gcccgccctt       60

ctccccgccc cctccccagc tccttgatct cccgtctgtt ttattactcc tggtgcgagt      120

ccggcggact ccgaggcccg ctatttgtta ccaactcgct ctcattggcg gggaggagag      180

cagcggagaa gggggtgggg aggggagggg aagggaaggg gtggccactg ccggagccga      240

ctccgcgctg ctgttggtgc cgctgccgct tctgctgcct ctgctgccgc cgccgccgcc      300

tccggctcct cgctcggccc ctctccgcct ccatgtgccg gatagcggga gcgccgcgga      360

ccctgctgcc gcttctggcg gccttgcttc aggcgtctgt ggaggcttct ggtgaaattg      420

cattatgcaa gactggattt cctgaagatg tttacagcgc agtcttaccg aaggatgtgc      480

acgaaggaca gccccttctc aatgtgaaat tcagcaactg caatagaaaa aggaaagttc      540

agtatgaaag cagcgagcca gcagatttca aggtggacga ggacggcacg gtgtatgctg      600

tgagaagctt ccctctcact gcagagcagg caaagttcct gatatatgcc caagacaaag      660

aaacccagga aaagtggcag gtagctgtaa acctgagccg ggagccaacc ctgactgagg      720

agcctatgaa ggaaccacat gaaattgaag aaatagtatt ccctagacaa cttgccaagc      780

acagtggagc tctacaaagg cagaagagag actgggtcat cccgccaatc aacttgccag      840

aaaactccag aggacccttt cctcaagagc ttgtcagaat caggtctgat agagataaaa      900

acctttccct gagatacagc gtcactgggc caggagctga ccagcctcca acgggcatct      960

tcattatcaa ccccatctca ggacagctgt cagtcacaaa gcctctggat cgagagctga     1020

tagcccggtt tcacttgaga gcacatgcag tggacatcaa tggcaatcaa gtggagaacc     1080

ccattgacat tgtcatcaat gttattgaca tgaatgataa cagacctgag tttctgcacc     1140

aggtttggaa tgggtctgtt ccagagggat caaagcctgg gacgtatgtg atgacggtca     1200

ctgccattga tgcggatgat ccaaatgccc tgaatggaat gctgcggtac aggatcctgt     1260

cccaggcgcc cagcacacct tcacccaaca tgtttacaat caacaatgag actggggaca     1320

tcatcactgt ggcagctggt ctggatcgag agaaagtgca acagtatacg ttaataattc     1380

aagccacaga catggaaggc aatcccactt atggcctttc aaacacagcc acagccgtca     1440

tcacggtgac agatgtcaat gacaatcctc cagagtttac tgccatgact ttctacggag     1500

aagtccctga gaacagggtg gacgtcattg tagccaacct aactgtcacg gacaaagatc     1560

agccccacac gccggcctgg aatgcggcat acagaatcag tggtggagac cctacaggaa     1620

ggtttgccat cctgacagac cccaacagca atgatgggct agtcacagtg gtaaaaccaa     1680

ttgactttga aacgaatagg atgtttgtcc ttactgttgc tgcagaaaac caagtgccat     1740

tagctaaagg cattcagcac ccacctcagt cgacagccac tgtgtctgtg acagttattg     1800

atgtcaatga aaatccttat tttgccccaa atcctaaaat cattcgccaa gaggaaggcc     1860

tccacgcagg taccatgctg accacgctca ctgctcagga ccccgatcga tatatgcaac     1920

agaatatcag atacacaaaa ttgtctgatc ctgccaactg gctgaaaata gaccccgtga     1980

atgggcagat cactactatt gccgttttgg acagagaatc gccaaatgta aaaaacaaca     2040

tctataatgc taccttcctt gcttctgaca atggaatccc gcctatgagt gggacaggaa     2100

cactgcaaat ctatttactt gatatcaatg acaacgcccc tcaggtgtta cctcaagagg     2160

cggagacctg tgaaactcca gaacccaact caattaacat cacagcactt gattatgaca     2220

tagacccaaa cgccgggccg ttcgcgtttg atcttccctt atctccagtg actattaaaa     2280

gaaactggac catcaaccgg cttaatggtg attttgctca gctcaattta aagataaaat     2340

ttttggaagc tggtatctat gaagttccca tcattatcac agattcaggg aatcccccca     2400

agtccaacat ttccatcctg cgtgtgaaag tttgtcagtg tgactccaat ggagactgca     2460

cggacgtgga caggatcgtg ggtgcagggc ttggcacggg cgccatcatc gctatccttc     2520

tgtgtatcat catcctgctg atccttgttc tcatgtttgt ggtatggatg aaacggcggg     2580

ataaagagcg ccaagccaag cagcttttaa ttgacccaga agatgatgta agagataata     2640

tattgaaata tgatgaagaa ggtggaggag aagaagacca ggactatgac ttgagccagc     2700

tccagcaacc agatactgtg gagcctgatg ccatcaagcc cgtgggaatc agacggctag     2760

acgagaggcc tatccatgct gagccacagt acccagtccg atccgcagcc ccacaccctg     2820

gggatattgg ggacttcatt aatgagggcc ttaaagctgc tgacaacgac cccacggcgc     2880

caccgtatga ctccctctta gtctttgact acgagggcag cggctccacg gctggctcct     2940

tgagctccct caactcctcc agtagcggtg gggaccagga ctatgactac ctgaatgact     3000

ggggaccccg cttcaagaaa ctggcggaca tgtacggcgg tggtgacgac tgaacggcag     3060

gacggacttg gcttttggac aagtatgaac agtttcacct gatattccca aaaaaaagca     3120

tacagaagct aggctttaac tctgtagtcc actagcaccg tgcttgctgg aggctttggc     3180

gtaggctgcg aaccagtttg ggctcccagg gaatatcagt gatccaatac tgtctggaaa     3240

acaccgagct cagctacact tgaattttac agtaaagaag cactgggatt tatgtgcctt     3300

tttgtacctt tttcagattg gaattagttt tctgtttaag gctttaatgg tactgatttc     3360

tgaaatgata aggaaaagac aaaatatttt gtggcgggag cagaaagtta aatgtgatac     3420

gcttcaaccc acttttgtta caatgcattt gcttttgtta agatacagaa cgaaacaacc     3480

agattaaaaa aaattaactc atggagtgat tttgttacct ttggggtggg ggggatgaga     3540

ccacaagata ggaaaatgta cattacttct agttttagac tttagatttt tttttttcac     3600

taaaatctta aaacttacgc agctggttgc agataaaggg agttttcata tcaccaattt     3660

gtagcaaaat gaattttttc ataaactaga atgttagaca cattttggtc ttaatccatg     3720

tacacttttt tattttctgt attttttcca cctcgctgta aaaatggtgt gtgtacataa     3780

tgtttatcag catagactat ggaggagtgc agagaactcg gaacatgtgt atgtattatt     3840

tggactttgg attcaggttt tttgcatgtt aatatctttc gttatgggta aagtatttac     3900

aaaacaaagt gacatttgat tcaactgttg agctgtagtt agaatactca atttttaatt     3960

ttttaatttt ttttaaattt ttttattttc tttttgtttg tttcgttttg gggaggggta     4020

aaagttctta gcacaatgtt ttacataatt tgtaccaaaa aaattacaca caaaaaaaaa     4080

aaaaagaaaa gaaaagaaaa gtgaaagggg tggcctgttt cttgcagcac tagcaagtgt     4140

gtgtttttaa aaaacaaaac aaacaaacaa aaaaataaat aaaaagagga aaaagaaaaa     4200

aaaaaaagct tttaaactgg agagacttct gaaacagctt tgcgtctgtg ttgtgtacca     4260

gaatacaaac aatacacctc tgaccccagc gttctgaata aaaagctaat tttggatctg     4320

g                                                                     4321


<210>  2
<211>  906
<212>  PRT
<213>  Mus musculus

<400>  2

Met Cys Arg Ile Ala Gly Ala Pro Arg Thr Leu Leu Pro Leu Leu Ala 
1               5                   10                  15      


Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
            20                  25                  30          


Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Pro Lys Asp 
        35                  40                  45              


Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
    50                  55                  60                  


Arg Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
65                  70                  75                  80  


Val Asp Glu Asp Gly Thr Val Tyr Ala Val Arg Ser Phe Pro Leu Thr 
                85                  90                  95      


Ala Glu Gln Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
            100                 105                 110         


Glu Lys Trp Gln Val Ala Val Asn Leu Ser Arg Glu Pro Thr Leu Thr 
        115                 120                 125             


Glu Glu Pro Met Lys Glu Pro His Glu Ile Glu Glu Ile Val Phe Pro 
    130                 135                 140                 


Arg Gln Leu Ala Lys His Ser Gly Ala Leu Gln Arg Gln Lys Arg Asp 
145                 150                 155                 160 


Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                165                 170                 175     


Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
            180                 185                 190         


Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
        195                 200                 205             


Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
    210                 215                 220                 


Leu Asp Arg Glu Leu Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
225                 230                 235                 240 


Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                245                 250                 255     


Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
            260                 265                 270         


Asn Gly Ser Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
        275                 280                 285             


Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
    290                 295                 300                 


Arg Tyr Arg Ile Leu Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
305                 310                 315                 320 


Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                325                 330                 335     


Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
            340                 345                 350         


Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
        355                 360                 365             


Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
    370                 375                 380                 


Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Val Ile Val 
385                 390                 395                 400 


Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                405                 410                 415     


Asn Ala Ala Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
            420                 425                 430         


Ile Leu Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
        435                 440                 445             


Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
    450                 455                 460                 


Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
465                 470                 475                 480 


Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                485                 490                 495     


Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
            500                 505                 510         


Gly Thr Met Leu Thr Thr Leu Thr Ala Gln Asp Pro Asp Arg Tyr Met 
        515                 520                 525             


Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
    530                 535                 540                 


Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
545                 550                 555                 560 


Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                565                 570                 575     


Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
            580                 585                 590         


Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
        595                 600                 605             


Glu Ala Glu Thr Cys Glu Thr Pro Glu Pro Asn Ser Ile Asn Ile Thr 
    610                 615                 620                 


Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
625                 630                 635                 640 


Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Asn Arg 
                645                 650                 655     


Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
            660                 665                 670         


Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
        675                 680                 685             


Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
    690                 695                 700                 


Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
705                 710                 715                 720 


Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                725                 730                 735     


Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
            740                 745                 750         


Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
        755                 760                 765             


Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
    770                 775                 780                 


Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
785                 790                 795                 800 


Ile Lys Pro Val Gly Ile Arg Arg Leu Asp Glu Arg Pro Ile His Ala 
                805                 810                 815     


Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
            820                 825                 830         


Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
        835                 840                 845             


Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
    850                 855                 860                 


Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
865                 870                 875                 880 


Asp Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                885                 890                 895     


Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
            900                 905     


<210>  3
<211>  3237
<212>  DNA
<213>  Xenopus laevis

<400>  3
tcggcacgag ctggagtgta caggactttt aagatgctgc tgggtgtctg cactgtgtcc       60

atgtgaatgt ggcattttta ttttgaattc cctccggaga caagatttca tcaagagttt      120

cctttggata ttaagtcaaa gtgcaagcaa tggagattct ctataagaag gcaataatct      180

gggggattta ctaaaattaa acaaacagat tgacattcgc tggatttatc aagcaatttt      240

gcatttacaa cactaccaaa aatgaagaaa gacttttgct tacacggttt acttttatgt      300

ttgggaattg cgtattgtag tcatgccaca tctttaagaa aaaacaataa actaaggcaa      360

tcattccatg gtcaccatga aaaaggcaaa gaagggcaag ttttacatag gtcaaagaga      420

ggatgggttt ggaatcaatt ttttgtaata gaagaataca ccggaccaga tcctgtactc      480

gttggacggc ttcactcaga tgttgactct ggagattgga agataaaata catactctca      540

ggagagggtg ctgggaccat ttttgtcatt gatgacaaat cagggaatat ccatgcaacc      600

aagaccctgg atcgagaaga aagggctcag tataccttaa tggctcaggc agttgacaga      660

gaaacaaata aaccactgga accaccatca gagtttatcg ttaaagttca agacataaat      720

gataatcccc cggagttctt gcatgaaaac taccacgcaa atgtgcctga gatgtccaat      780

gtgggtacat cagtaattca agtaacagcc tctgatgcag atgatccaac atatggaaac      840

agcgctaagc ttgtgtatag tattctcgaa gggcagccat atttttcagt cgaagcacaa      900

tcaggaatca ttaggactgc ccttccaaac atggacagag aagccaagga agaataccat      960

gttgttattc aagcaaagga tatgggagga catatgggag gactctcagg gacaactaaa     1020

gtgacaataa cgctgacaga tgtcaatgac aatccaccaa agtttccaca aagtgcgtac     1080

cccatgtctg tgtcagaagc tgctgtccca ggggaagagg ttggcagaat aaaagctaaa     1140

gatccagaca ttggagaaaa tggcttaata aagtaccgta ttcttgaagg agatggggca     1200

gagatgtttg aaatcacagc tgattatgta actcaggaag gcgttgtaaa gctaaaaaag     1260

gtggtggatt atgaaaccaa gaagttctac agtatgaagg ttgaagctgt caacgttcat     1320

attgatccca gattccttag ccggggacca ttcaaagaca ctgctactgt taagatctca     1380

gtagaggatt ttgatgaacc gcctattttc ttagaaagaa gttacatttt ggaagtatat     1440

gaaaatgctc catcggatac tgtggtcgga agagtgcacg ctaaagaccc agatgctgct     1500

aacagcccaa ttaggtattc aatcgatcgc cacactgacc ttgacagatt cttcagcatc     1560

aacccagagg atggtgtcat caaaaccaca aagggtttgg atagagagga aagcccttgg     1620

cacaacatct cagtcattgc aactgaagtc cacaatcgaa ttcatgaaac tagagttcca     1680

gtagctatta aagtcttgga taagaatgac aatgctccgg aatttgcaaa gccctatgaa     1740

gcttttgtct gtgaaaatgc tccaatcaat caggagtttt tgaccatcac tgcagtagat     1800

aaagatgata cagccaatgg acttcgtttt ctctttagtt tccccccaga aattgtacat     1860

ccaaatccaa atttcaccat aatagacaaa cgagataaca cagcaagcat ccgtgttggc     1920

cgtggagttt tcagccgaca gaaacaagac ttgtatttgg ttcctattgt tataagtgat     1980

gggggaagcc caccgatgag cagcaccaat accctttctg tccgaatctg cagttgcaat     2040

agtgatggat cccaactatc ttgtaatgct gaaccccaat cccttaacgc tggactcagt     2100

actggagcac tgattgcaat ccttgcttgc attgtaattt tattagtgat tgtggttttg     2160

tttgtgactc tgaggagaga gaagaaggaa cctctaattg tctttgaaga ggaagatatc     2220

cgggaaaata taattacata tgatgatgaa ggtggtggag aggaagacac cgaagcattt     2280

gacattgcaa cactgcagaa tcctgatggg attaatggat ttatgccacg gaaagatatc     2340

aaacccgaat ttcaatataa ccccagagat attggaataa gaccagcacc aaacagtgtt     2400

gacgttgatg acttcattaa cacaaggata catgaggccg ataatgaccc tgcagctccg     2460

ccttatgact ccattcagat ctatggatac gaagggagag gttctgtggc tggctctctt     2520

agttcattag agtcagcctc tacagattca gatttggact atgattatct acaaaactgg     2580

ggacctcgat ttaagaaact agcaaattta tatgggtcca aagacacttg tgaagatgat     2640

tcttaacaaa taagttctga atttggcctt atgaactgca taatgtactg aaatatccag     2700

agtaaacatt aacaggtatt tttttaaagg aaaacatgaa aaaggcttct ttaaccttcc     2760

aaggtttaca aacaggattc cttccaaaac aagaactgtt aaatggtggt ggatactgtg     2820

aaaaccctat ggcctgtgta gaagttgtgt attcattttt ttttttgttt tttgtttttt     2880

ttccaagaaa ccacttgtaa aatgcagcct atttaaggga atggaaatgc aggaaaaacg     2940

caacaaaaaa ggggaatctt tacagtatta aacataacca tcaaatcttc tcaaacaaag     3000

cttccacaca aaaaaaaaaa aagataacag ttttgagctg taatttcgcc ttaaactatg     3060

gacactttat atgtagtgca tttttaaact tgaaaaaaat atatatataa tatccagcca     3120

gcttcaatcc atataatgta tgtacagtaa aatgtacaat tattctgtct cttgagcatc     3180

agacttgtta ctgctgattc ttgtaaatct tttttgctta taatcccctc gtgccga        3237


<210>  4
<211>  794
<212>  PRT
<213>  Xenopus laevis

<400>  4

Met Lys Lys Asp Phe Cys Leu His Gly Leu Leu Leu Cys Leu Gly Ile 
1               5                   10                  15      


Ala Tyr Cys Ser His Ala Thr Ser Leu Arg Lys Asn Asn Lys Leu Arg 
            20                  25                  30          


Gln Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


His Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Val Asp Ser Gly Asp Trp Lys Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Glu Thr Asn Lys Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Asn Tyr His Ala Asn Val Pro Glu Met Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Ser Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Ala 
            260                 265                 270         


Tyr Pro Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Ile Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Ile Lys 
    290                 295                 300                 


Tyr Arg Ile Leu Glu Gly Asp Gly Ala Glu Met Phe Glu Ile Thr Ala 
305                 310                 315                 320 


Asp Tyr Val Thr Gln Glu Gly Val Val Lys Leu Lys Lys Val Val Asp 
                325                 330                 335     


Tyr Glu Thr Lys Lys Phe Tyr Ser Met Lys Val Glu Ala Val Asn Val 
            340                 345                 350         


His Ile Asp Pro Arg Phe Leu Ser Arg Gly Pro Phe Lys Asp Thr Ala 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Phe Asp Glu Pro Pro Ile Phe Leu 
    370                 375                 380                 


Glu Arg Ser Tyr Ile Leu Glu Val Tyr Glu Asn Ala Pro Ser Asp Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Ser 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Val Ile Lys Thr Thr Lys Gly Leu Asp Arg 
        435                 440                 445             


Glu Glu Ser Pro Trp His Asn Ile Ser Val Ile Ala Thr Glu Val His 
    450                 455                 460                 


Asn Arg Ile His Glu Thr Arg Val Pro Val Ala Ile Lys Val Leu Asp 
465                 470                 475                 480 


Lys Asn Asp Asn Ala Pro Glu Phe Ala Lys Pro Tyr Glu Ala Phe Val 
                485                 490                 495     


Cys Glu Asn Ala Pro Ile Asn Gln Glu Phe Leu Thr Ile Thr Ala Val 
            500                 505                 510         


Asp Lys Asp Asp Thr Ala Asn Gly Leu Arg Phe Leu Phe Ser Phe Pro 
        515                 520                 525             


Pro Glu Ile Val His Pro Asn Pro Asn Phe Thr Ile Ile Asp Lys Arg 
    530                 535                 540                 


Asp Asn Thr Ala Ser Ile Arg Val Gly Arg Gly Val Phe Ser Arg Gln 
545                 550                 555                 560 


Lys Gln Asp Leu Tyr Leu Val Pro Ile Val Ile Ser Asp Gly Gly Ser 
                565                 570                 575     


Pro Pro Met Ser Ser Thr Asn Thr Leu Ser Val Arg Ile Cys Ser Cys 
            580                 585                 590         


Asn Ser Asp Gly Ser Gln Leu Ser Cys Asn Ala Glu Pro Gln Ser Leu 
        595                 600                 605             


Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Ala Cys Ile 
    610                 615                 620                 


Val Ile Leu Leu Val Ile Val Val Leu Phe Val Thr Leu Arg Arg Glu 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu Asp Ile Arg Glu Asn 
                645                 650                 655     


Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala 
            660                 665                 670         


Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly Ile Asn Gly Phe Met 
        675                 680                 685             


Pro Arg Lys Asp Ile Lys Pro Glu Phe Gln Tyr Asn Pro Arg Asp Ile 
    690                 695                 700                 


Gly Ile Arg Pro Ala Pro Asn Ser Val Asp Val Asp Asp Phe Ile Asn 
705                 710                 715                 720 


Thr Arg Ile His Glu Ala Asp Asn Asp Pro Ala Ala Pro Pro Tyr Asp 
                725                 730                 735     


Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser Val Ala Gly Ser 
            740                 745                 750         


Leu Ser Ser Leu Glu Ser Ala Ser Thr Asp Ser Asp Leu Asp Tyr Asp 
        755                 760                 765             


Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu Ala Asn Leu Tyr 
    770                 775                 780                 


Gly Ser Lys Asp Thr Cys Glu Asp Asp Ser 
785                 790                 


<210>  5
<211>  3701
<212>  DNA
<213>  Mus musculus

<400>  5
gtccaatcag tgcgctcaga ctcagagccc taggctcctg ctctttaaat taccgagcct       60

tgtggagacc ccggcacctg gccttaagct cagccctgag gatggtactt tgagtgaatg      120

accaccttgg agaccgttct tctgtttccc ttgttaccag ccaggaggca gaagagtcca      180

ccggtccagg aaagacccat ttcccttgag tttccagaaa gtacctcatg cttgagagat      240

caggccaaca actatggctc tcgtcttcag tgccctgctg ttactggggc tgtgtggaaa      300

gatctcttca gaaggtcagc ctgcattcca taacactcct ggggctatga attatgaatt      360

gcctaccacc aaatatgaga cccaagatac cttcaatgct gggattgttg gccctctcta      420

caaaatggtg cacatcttcc tcaacgtggt ccagccgaat gacttccctc tagatttgat      480

caaaaaactc atacagaaca agaactttga catctcagtt gattccaagg agccagaaat      540

catagtcttg gctctgaaga ttgccctcta tgagatcgga gtccttatct gcgccatcct      600

gggactgctg ttcattatcc tcatgcctct ggtgggctgc ttcttttgta tgtgccgttg      660

ctgcaacaaa tgcggcggag agatgcacca gcggcagaag cagaatgcgc catgcaggag      720

gaagtgcttg ggcctctccc tcctggtgat ttgtctgctc atgagccttg gcattatata      780

tggctttgtg gctaaccagc agaccaggac tcggatcaaa gggacccaga aactggcaaa      840

gagcaatttc agagactttc aaacactcct gactgaaaca ccaaagcaaa ttgactatgt      900

agtggagcag tacaccaaca ccaagaacaa ggcattctca gacctggatg gcatcggctc      960

cgtgctggga ggcagaataa aggaccaact aaaacccaaa gtaactcctg tcctcgaaga     1020

gattaaggcc atggcgacag ccatcaaaca gaccaaggat gccctgcaga acatgagcag     1080

cagcctgaaa agtctccaag atgcagccac ccagctcaat accaacctga gctctgtgag     1140

aaacagcatc gagaattcgc tcagcagcag tgactgtacc tcagatccag ccagcaagat     1200

ctgcgatagc atcagaccaa gcctaagcag tctggggagc agcctcaatt caagtcagct     1260

cccatcagtg gatagagaac tcaacactgt tactgaagtc gacaaaactg atctggagag     1320

cctcgtcaaa agggggtata cgacaattga tgaaataccc aatacaatac aaaaccaaac     1380

tgtggatgtc atcaaagacg tcaaaaatac cttggactcc attagctcca acattaagga     1440

catgagccaa agtattccta ttgaggatat gctgttacag gtctcccatt accttaataa     1500

cagcaacaga tacttaaacc aggagctgcc caagctggaa gaatatgact cgtactggtg     1560

gctgggtggc ttgattgtct gctttctgct gactctcatt gtgaccttct ttttcctggg     1620

cttgctgtgt ggtgtgtttg gctatgacaa gcatgccacc ccaactagaa gaggctgtgt     1680

gtccaacact ggaggcatct tcctcatggc tggggttgga ttcggcttcc ttttttgctg     1740

gatattgatg atccttgtgg ttcttacgtt tgttgttggt gcaaatgtgg aaaagttgct     1800

ctgcgaacct tatgaaaaca agaaattatt acaggttttg gacactccct atctgctcaa     1860

ggaacaatgg caattttatc tttctggcat gctattcaat aacccagaca ttaacatgac     1920

ctttgagcaa gtctacaggg attgcaaaag aggtcgaggt atatatgctg cttttcagct     1980

tgagaatgtc gtcaacgtca gtgatcattt caacattgac cagatttctg aaaacataaa     2040

tacggagttg gaaaacctga atgtgaacat tgatagcatt gaactgttgg ataacacagg     2100

aaggaagagc ctcgaggact ttgcacattc tgggatagat acaatcgatt attccacata     2160

cttgaaggag actgagaaat cccctactga agtgaatctg ctgacatttg cctctaccct     2220

ggaagcaaaa gcaaaccagt tgcctgaagg aaagctgaaa caggccttct tactggatgt     2280

acagaatata agagccatcc accagcatct cctccctcct gtgcagcaat cactgaaatt     2340

tgtgagggtg aggaatacgt taagacaaag tgtctggacc ctccagcaaa caagcaacaa     2400

gttgccggag aaagtgaaga agatccttgc ctctttggac tctgttcagc atttcctcac     2460

caataacgtt tccctcatcg ttatcgggga aacgaagaag tttgggaaaa caatactagg     2520

ctactttgaa cattatctgc actgggtctt ttatgccatc acagagaaga tgacatcctg     2580

caaacccatg gccaccgcga tggactctgc tgttaatggc attctgtgtg gctatgttgc     2640

ggaccctctg aatttgttct ggttcggcat agggaaagcc acggtgctct tacttccggc     2700

tgtaatcatt gctatcaagc tggccaagta ctatcgcagg atggattcag aggatgtata     2760

cgacgacccg tctcgatact gacaactgga gttgaagctg cttgaacaac aagatagtca     2820

acatggaaag catcacagat tttggatagt ttctgagtct tctagaacgt tccaagtgca     2880

gaagaaacct ggtggagact caggcgggca ctaggaacat ggcatcagtg gtcttagggt     2940

agcactttgt caggaatgaa cagtcatcat ggttataatc cacatatcca ttgcaactca     3000

tgaatgattc tctcctgttt tgtttttaac ttttcttttt acactgattt tctatttaga     3060

cactaaaaca tataggggtg cttattcccc ctggatacat ttacctgtga accagctatt     3120

ccggtgtcat agctgggtac ctaacttact tccatatgtg aagtgtgcta aacacaaacc     3180

agtttacaga agagatgtat tttgtgtata gtaaactgta tatataccct tttaccacag     3240

tcagtttttt aaacaaatga atactctaga tttttcttct aaatgaggtt actgttgggg     3300

tggttgtgac ctagtgatgc tgtagaaagg agtctgcatt cactaaaagt gtgtcaacct     3360

agagcaggca atgcccttcc ttgtggattt ctgtctgctc gttttggagc tacctgcggt     3420

ttagaaatag aattcaagaa caatcacgga gtttcccact tgatgccact gccaaagtca     3480

gaacaaggga tcttgagaga aggaactgtc gctcagctgg gagcggaatc attatcgcaa     3540

tcacaggtcc tggttcacag tttagtggca ctctctggtt tgtaagaatg ggcattacgt     3600

tcagtgtcat ctggtcatct gtgatgtgtg tcatcagcct gtcctgatgt tgagatttaa     3660

aataaagcat gaatgaacag aaaaaaaaaa aaaaaaaaaa a                         3701


<210>  6
<211>  842
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Leu Val Phe Ser Ala Leu Leu Leu Leu Gly Leu Cys Gly Lys 
1               5                   10                  15      


Ile Ser Ser Glu Gly Gln Pro Ala Phe His Asn Thr Pro Gly Ala Met 
            20                  25                  30          


Asn Tyr Glu Leu Pro Thr Thr Lys Tyr Glu Thr Gln Asp Thr Phe Asn 
        35                  40                  45              


Ala Gly Ile Val Gly Pro Leu Tyr Lys Met Val His Ile Phe Leu Asn 
    50                  55                  60                  


Val Val Gln Pro Asn Asp Phe Pro Leu Asp Leu Ile Lys Lys Leu Ile 
65                  70                  75                  80  


Gln Asn Lys Asn Phe Asp Ile Ser Val Asp Ser Lys Glu Pro Glu Ile 
                85                  90                  95      


Ile Val Leu Ala Leu Lys Ile Ala Leu Tyr Glu Ile Gly Val Leu Ile 
            100                 105                 110         


Cys Ala Ile Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly 
        115                 120                 125             


Cys Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met 
    130                 135                 140                 


His Gln Arg Gln Lys Gln Asn Ala Pro Cys Arg Arg Lys Cys Leu Gly 
145                 150                 155                 160 


Leu Ser Leu Leu Val Ile Cys Leu Leu Met Ser Leu Gly Ile Ile Tyr 
                165                 170                 175     


Gly Phe Val Ala Asn Gln Gln Thr Arg Thr Arg Ile Lys Gly Thr Gln 
            180                 185                 190         


Lys Leu Ala Lys Ser Asn Phe Arg Asp Phe Gln Thr Leu Leu Thr Glu 
        195                 200                 205             


Thr Pro Lys Gln Ile Asp Tyr Val Val Glu Gln Tyr Thr Asn Thr Lys 
    210                 215                 220                 


Asn Lys Ala Phe Ser Asp Leu Asp Gly Ile Gly Ser Val Leu Gly Gly 
225                 230                 235                 240 


Arg Ile Lys Asp Gln Leu Lys Pro Lys Val Thr Pro Val Leu Glu Glu 
                245                 250                 255     


Ile Lys Ala Met Ala Thr Ala Ile Lys Gln Thr Lys Asp Ala Leu Gln 
            260                 265                 270         


Asn Met Ser Ser Ser Leu Lys Ser Leu Gln Asp Ala Ala Thr Gln Leu 
        275                 280                 285             


Asn Thr Asn Leu Ser Ser Val Arg Asn Ser Ile Glu Asn Ser Leu Ser 
    290                 295                 300                 


Ser Ser Asp Cys Thr Ser Asp Pro Ala Ser Lys Ile Cys Asp Ser Ile 
305                 310                 315                 320 


Arg Pro Ser Leu Ser Ser Leu Gly Ser Ser Leu Asn Ser Ser Gln Leu 
                325                 330                 335     


Pro Ser Val Asp Arg Glu Leu Asn Thr Val Thr Glu Val Asp Lys Thr 
            340                 345                 350         


Asp Leu Glu Ser Leu Val Lys Arg Gly Tyr Thr Thr Ile Asp Glu Ile 
        355                 360                 365             


Pro Asn Thr Ile Gln Asn Gln Thr Val Asp Val Ile Lys Asp Val Lys 
    370                 375                 380                 


Asn Thr Leu Asp Ser Ile Ser Ser Asn Ile Lys Asp Met Ser Gln Ser 
385                 390                 395                 400 


Ile Pro Ile Glu Asp Met Leu Leu Gln Val Ser His Tyr Leu Asn Asn 
                405                 410                 415     


Ser Asn Arg Tyr Leu Asn Gln Glu Leu Pro Lys Leu Glu Glu Tyr Asp 
            420                 425                 430         


Ser Tyr Trp Trp Leu Gly Gly Leu Ile Val Cys Phe Leu Leu Thr Leu 
        435                 440                 445             


Ile Val Thr Phe Phe Phe Leu Gly Leu Leu Cys Gly Val Phe Gly Tyr 
    450                 455                 460                 


Asp Lys His Ala Thr Pro Thr Arg Arg Gly Cys Val Ser Asn Thr Gly 
465                 470                 475                 480 


Gly Ile Phe Leu Met Ala Gly Val Gly Phe Gly Phe Leu Phe Cys Trp 
                485                 490                 495     


Ile Leu Met Ile Leu Val Val Leu Thr Phe Val Val Gly Ala Asn Val 
            500                 505                 510         


Glu Lys Leu Leu Cys Glu Pro Tyr Glu Asn Lys Lys Leu Leu Gln Val 
        515                 520                 525             


Leu Asp Thr Pro Tyr Leu Leu Lys Glu Gln Trp Gln Phe Tyr Leu Ser 
    530                 535                 540                 


Gly Met Leu Phe Asn Asn Pro Asp Ile Asn Met Thr Phe Glu Gln Val 
545                 550                 555                 560 


Tyr Arg Asp Cys Lys Arg Gly Arg Gly Ile Tyr Ala Ala Phe Gln Leu 
                565                 570                 575     


Glu Asn Val Val Asn Val Ser Asp His Phe Asn Ile Asp Gln Ile Ser 
            580                 585                 590         


Glu Asn Ile Asn Thr Glu Leu Glu Asn Leu Asn Val Asn Ile Asp Ser 
        595                 600                 605             


Ile Glu Leu Leu Asp Asn Thr Gly Arg Lys Ser Leu Glu Asp Phe Ala 
    610                 615                 620                 


His Ser Gly Ile Asp Thr Ile Asp Tyr Ser Thr Tyr Leu Lys Glu Thr 
625                 630                 635                 640 


Glu Lys Ser Pro Thr Glu Val Asn Leu Leu Thr Phe Ala Ser Thr Leu 
                645                 650                 655     


Glu Ala Lys Ala Asn Gln Leu Pro Glu Gly Lys Leu Lys Gln Ala Phe 
            660                 665                 670         


Leu Leu Asp Val Gln Asn Ile Arg Ala Ile His Gln His Leu Leu Pro 
        675                 680                 685             


Pro Val Gln Gln Ser Leu Lys Phe Val Arg Val Arg Asn Thr Leu Arg 
    690                 695                 700                 


Gln Ser Val Trp Thr Leu Gln Gln Thr Ser Asn Lys Leu Pro Glu Lys 
705                 710                 715                 720 


Val Lys Lys Ile Leu Ala Ser Leu Asp Ser Val Gln His Phe Leu Thr 
                725                 730                 735     


Asn Asn Val Ser Leu Ile Val Ile Gly Glu Thr Lys Lys Phe Gly Lys 
            740                 745                 750         


Thr Ile Leu Gly Tyr Phe Glu His Tyr Leu His Trp Val Phe Tyr Ala 
        755                 760                 765             


Ile Thr Glu Lys Met Thr Ser Cys Lys Pro Met Ala Thr Ala Met Asp 
    770                 775                 780                 


Ser Ala Val Asn Gly Ile Leu Cys Gly Tyr Val Ala Asp Pro Leu Asn 
785                 790                 795                 800 


Leu Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Leu Leu Leu Pro Ala 
                805                 810                 815     


Val Ile Ile Ala Ile Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser 
            820                 825                 830         


Glu Asp Val Tyr Asp Asp Pro Ser Arg Tyr 
        835                 840         


<210>  7
<211>  3306
<212>  DNA
<213>  Mus musculus

<400>  7
gaattcccgc gcggccgcca gagctccggc ccgggggctg cctgtgtgtt cctggcccgg       60

cgtggcgact gctctccggg ctggcggggg ccgggcgtga gcccgggcct cagcgttcct      120

gagcgctgcg agtgttcact actcgccagc aaagtttgga gtaggcaacg caagctccag      180

tcctttcttc tgctgctgcc cagatccgag agcagctccg gtgtatgtct agctgttctg      240

cgatcccggc gcgcgtgaag cctcggaacc ttggcgccgg ctgctaccca aggaatcgtt      300

ctctttttgg agttttcctc cgagatcatc gcctgctcca tcccgatcca ctctgggctc      360

cggcgcagca ccgagcgcag aggagcgctg ccattcaagt ggcagccaca gcagcagcag      420

cagcagcagt gggagcagga acagcagtaa caacagcaac agcagcacag ccgcctcaga      480

gctttgctcc tgagcccctg tgggctgaag gcattgcagg tagcccatgg tctcagaaga      540

agtgtgcaga tgggattacc gtccacgtgg agatatggaa gaggaccagg gattggcact      600

gtgaccatgg tcagctgggg gcgcttcatc tgcctggtct tggtcaccat ggcaaccttg      660

tccctggccc ggccctcctt cagtttagtt gaggatacca ctttagaacc agaagagcca      720

ccaaccaaat accaaatctc ccaaccagaa gcgtacgtgg ttgcccccgg ggaatcgcta      780

gagttgcagt gcatgttgaa agatgccgcc gtgatcagtt ggactaagga tggggtgcac      840

ttggggccca acaataggac agtgcttatt ggggagtatc tccagataaa aggtgccaca      900

cctagagact ccggcctcta tgcttgtact gcagctagga cggtagacag tgaaacttgg      960

atcttcatgg tgaatgtcac agatgccatc tcatctggag atgatgagga cgacacagat     1020

agctccgaag acgttgtcag tgagaacagg agcaaccaga gagcaccgta ctggaccaac     1080

accgagaaga tggagaagcg gctccacgct tgtcctgccg ccaacactgt gaagttccgc     1140

tgtccggctg gggggaatcc aacgtccaca atgaggtggt taaaaaacgg gaaggagttt     1200

aagcaggagc atcgcattgg aggctataag gtacgaaacc agcactggag ccttattatg     1260

gaaagtgtgg tcccgtcaga caaaggcaac tacacctgcc tggtggagaa tgaatacggg     1320

tccatcaacc acacctacca cctggatgtc gttgaacgtt caccacaccg tcccatcctc     1380

caagctggac tgcctgcaaa tgcctccacg gtggtcggag gggatgtgga gtttgtctgc     1440

aaggtttaca gcgatgccca gccccacatc cagtggatca agcacgtgga aaagaacggc     1500

agtaaaaacg ggcctgatgg gctgccctac ctcaaggttc tgaaagctgc cggtgttaac     1560

accacggaca aagagattga ggttctctat attcggaatg taacttttga ggatgctggg     1620

gaatatacgt gcttggcggg taattctatc gggatatcct ttcactctgc atggttgaca     1680

gttctgccag cgcctgtgag agagaaggag atcacggctt ccccagatta tctggagata     1740

gctatttact gcataggggt cttcttaatc gcctgcatgg tggtgacagt catcttttgc     1800

cgaatgaaga ccacgaccaa gaagccagac ttcagcagcc agccagctgt gcacaagctg     1860

accaagcgca tccccctgcg gagacaggta acagtttcgg ccgagtccag ctcctccatg     1920

aactccaaca ccccgctggt gaggataaca acgcgtctgt cctcaacagc ggacaccccg     1980

atgctagcag gggtctccga gtatgagttg ccagaggatc caaagtggga attccccaga     2040

gataagctga cgctgggcaa acccctgggg gaaggttgct tcgggcaagt agtcatggct     2100

gaagcagtgg gaatcgataa agacaaaccc aaggaggcgg tcaccgtggc agtgaagatg     2160

ttgaaagatg atgccacaga gaaggacctg tctgatctgg tatcagagat ggagatgatg     2220

aagatgattg ggaaacataa gaacattatc aacctcctgg gggcctgcac gcaggatgga     2280

cctctctacg tcatagttga atatgcatcg aaaggcaacc tccgggaata cctccgagcc     2340

cggaggccac ctggcatgga gtactcctat gacattaacc gtgtccccga ggagcagatg     2400

accttcaagg acttggtgtc ctgcacctac cagctggcta gaggcatgga gtacttggct     2460

tcccaaaaat gtatccatcg agatttggct gccagaaacg tgttggtaac agaaaacaat     2520

gtgatgaaga tagcagactt tggcctggcc agggatatca acaacataga ctactataaa     2580

aagaccacaa atgggcgact tccagtcaag tggatggctc ctgaagccct ttttgataga     2640

gtttacactc atcagagcga tgtctggtcc ttcggggtgt taatgtggga gatctttact     2700

ttagggggct caccctaccc agggattccc gtggaggaac tttttaagct gctcaaagag     2760

ggacacagga tggacaagcc caccaactgc accaatgaac tgtacatgat gatgagggat     2820

tgctggcatg ctgtaccctc acagagaccc acattcaagc agttggtcga agacttggat     2880

cgaattctga ctctcacaac caatgaggaa tacttggatc tcacccagcc tctcgaacag     2940

tattctccta gttaccccga cacaagtagc tcttgttctt caggggacga ttctgtgttt     3000

tctccagacc ccatgcctta tgaaccctgt ctgcctcagt atccacacat aaacggcagt     3060

gttaaaacat gagtgaatgt gtcttcctgt ccccaaacag gacagcacca ggaacctact     3120

tacactgagc agagaggctg tgctccagag cctgtgacac gcctccactt gtatatatgg     3180

atcagaggag taaatagtgg gaagcatatt tgtcacgtgt gtaaagattt atacagttgg     3240

aacatgtact acaggaagga gactgttctg atagtgacag ccgccaccat gccacctttg     3300

accaca                                                                3306


<210>  8
<211>  821
<212>  PRT
<213>  Mus musculus

<400>  8

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Leu Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Ala Tyr Val Val Ala Pro Gly Glu Ser Leu Glu Leu Gln Cys Met Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ala Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Ile Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Ser Ser Glu Asp Val Val 
    130                 135                 140                 


Ser Glu Asn Arg Ser Asn Gln Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Cys Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Thr Ser Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Leu Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Asn Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Val Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Phe Cys Arg Met 
385                 390                 395                 400 


Lys Thr Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Thr Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Thr Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Ser Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  9
<211>  3037
<212>  DNA
<213>  Mus musculus

<400>  9
ggcgagggga gagagccggg agaggcgagc ggcggcgcgg caggcgcgga acgggcgcac       60

ggacgatcga acgcgcggcc gccagagctc cggcgcgggg gctgcctgtg tgttcctggc      120

ccggcgtggc gactgctctc cgggctggcg ggggccgggc gtgagcccgg gcctcagcgt      180

tcctgagcgc tgcgagtgtt cactactcgc cagcaaagtt tggagtaggc aacgccaagc      240

tccagtcctt tcttctgctg ctgcccagat ccgagagcag ctccggtgtc atgtcctagc      300

tgttctgcga tccccggcgc gcgtgaagcc tcggaacctt cgcgccggct gctacccaag      360

gaatcgttct ctttttggag ttttcctccg agatcatcgc ctgctccatc ccgatccact      420

ctgggctccg gcgcagaccg agcgcagagg agcgctgcca ttcaagtggc agccacagca      480

gcagcagcag cagcagtggg agcaggaaca gcagtaacaa cagcaacagc agcacagccg      540

cctcagagct ttggctcctg agccccctgt gggctgaagg cattgcaggt agcccatggt      600

ctcagaagaa gtgtgcagat gggattaccg tccacgtgga gatatggaag aggaccaggg      660

attggcactg tgaccatggt cagctggggg cgcttcatct gcctggtctt ggtcaccatg      720

gcaaccttgt ccctggcccg gccctccttc agtttagttg aggataccac tttagaacca      780

gaaggagcac cgtactggac caacaccgag aagatggaga agcggctcca cgctgtccct      840

gccgccaaca ctgtgaagtt ccgctgtccg gctgggggga atccaacgcc cacaatgagg      900

tggttaaaaa acgggaagga gtttaagcag gagcatcgca ttggaggcta taaggtacga      960

aaccagcact ggagccttat tatggaaagt gtggtcccgt cagacaaagg caactacacc     1020

tgcctggtgg agaatgaata cgggtccatc aaccacacct accacctcga tgtcgttgaa     1080

cggtcaccac accggcccat cctccaagct ggactgcctg caaatgcctc cacggtggtc     1140

ggaggggatg tggagtttgt ctgcaaggtt tacagcgatg cccagcccca catccagtgg     1200

atcaagcacg tggaaaagaa cggcagtaaa tacgggcctg atgggctgcc ctacctcaag     1260

gtcctgaagc actcggggat aaatagctcc aatgcagaag tgctggctct gttcaatgtg     1320

acggagatgg atgctgggga atatatatgt aaggtctcca attatatagg gcaggccaac     1380

cagtctgcct ggctcactgt cctgcccaaa cagcaagcgc ctgtgagaga gaaggagatc     1440

acggcttccc cagattatct ggagatagct atttactgca taggggtctt cttaatcgcc     1500

tgcatggtgg tgacagtcat cttttgccga atgaagacca cgaccaagaa gccagacttc     1560

agcagccagc cagctgtgca caagctgacc aagcgcatcc ccctgcggag acaggtaaca     1620

gtttcggccg agtccagctc ctccatgaac tccaacaccc cgctggtgag gataacaacg     1680

cgtctgtcct caacagcgga caccccgatg ctagcagggg tctccgagta tgagttgcca     1740

gaggatccaa agtgggaatt ccccagagat aagctgacgc tgggcaaacc cctgggggaa     1800

ggttgcttcg ggcaagtagt catggctgaa gcagtgggaa tcgataaaga caaacccaag     1860

gaggcggtca ccgtggcagt gaagatgttg aaagatgatg ccacagagaa ggacctgtct     1920

gatctggtat cagagatgga gatgatgaag atgattggga aacataagaa cattatcaac     1980

ctcctggggg cctgcacgca ggatggacct ctctacgtca tagttgaata tgcatcgaaa     2040

ggcaacctcc gggaatacct ccgagcccgg aggccacctg gcatggagta ctcctatgac     2100

attaaccgtg tccccgagga gcagatgacc ttcaaggact tggtgtcctg cacctaccag     2160

ctggctagag gcatggagta cttggcttcc caaaaatgta tccatcgaga tttggctgcc     2220

agaaacgtgt tggtaacaga aaacaatgtg atgaagatag cagactttgg cctggccagg     2280

gatatcaaca acatagacta ctataaaaag accacaaatg ggcgacttcc agtcaagtgg     2340

atggctcctg aagccctttt tgatagagtt tacactcatc agagcgatgt ctggtccttc     2400

ggggtgttaa tgtgggagat ctttacttta gggggctcac cctacccagg gattcccgtg     2460

gaggaacttt ttaagctgct caaagaggga cacaggatgg acaagcccac caactgcacc     2520

aatgaactgt acatgatgat gagggattgc tggcatgctg taccctcaca gagacccaca     2580

ttcaagcagt tggtcgaaga cttggatcga attctgactc tcacaaccaa tgaggaatac     2640

ttggatctca cccagcctct cgaacagtat tctcctagtt accccgacac aaggagctct     2700

tgttcttcag gggacgattc tgtgttttct ccagacccca tgccttatga accctgtctg     2760

cctcagtatc cacacataaa cggcagtgtt aaaacatgag tgaatgtgtc ttcctgtccc     2820

caaacaggac agcaccagga acctacttac actgagcaga gaggctgtct cagagcctgt     2880

gacacgcctc cacttgtata tatggatcag aggagtaaat agtgggaagc atattgtcac     2940

gtgtgtaaag atttatacag ttcggaaaca tgttacctaa ccaggaaagg aagactgttt     3000

tcctgataag tggacagccg caagccacca tgccacc                              3037


<210>  10
<211>  707
<212>  PRT
<213>  Mus musculus

<400>  10

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Leu Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu 
        35                  40                  45              


Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys 
    50                  55                  60                  


Pro Ala Gly Gly Asn Pro Thr Pro Thr Met Arg Trp Leu Lys Asn Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn 
                85                  90                  95      


Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly 
            100                 105                 110         


Asn Tyr Thr Cys Leu Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
        115                 120                 125             


Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
    130                 135                 140                 


Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu 
145                 150                 155                 160 


Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile 
                165                 170                 175     


Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro 
            180                 185                 190         


Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser Asn Ala Glu 
        195                 200                 205             


Val Leu Ala Leu Phe Asn Val Thr Glu Met Asp Ala Gly Glu Tyr Ile 
    210                 215                 220                 


Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser Ala Trp Leu 
225                 230                 235                 240 


Thr Val Leu Pro Lys Gln Gln Ala Pro Val Arg Glu Lys Glu Ile Thr 
                245                 250                 255     


Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe 
            260                 265                 270         


Leu Ile Ala Cys Met Val Val Thr Val Ile Phe Cys Arg Met Lys Thr 
        275                 280                 285             


Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu 
    290                 295                 300                 


Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser 
305                 310                 315                 320 


Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg 
                325                 330                 335     


Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr 
            340                 345                 350         


Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr 
        355                 360                 365             


Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala 
    370                 375                 380                 


Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val 
385                 390                 395                 400 


Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp 
                405                 410                 415     


Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn 
            420                 425                 430         


Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val 
        435                 440                 445             


Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala 
    450                 455                 460                 


Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro 
465                 470                 475                 480 


Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu 
                485                 490                 495     


Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp 
            500                 505                 510         


Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile 
        515                 520                 525             


Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys 
    530                 535                 540                 


Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
545                 550                 555                 560 


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
                565                 570                 575     


Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
            580                 585                 590         


Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met 
        595                 600                 605             


Asp Lys Pro Thr Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp 
    610                 615                 620                 


Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
625                 630                 635                 640 


Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu 
                645                 650                 655     


Asp Leu Thr Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr 
            660                 665                 670         


Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro 
        675                 680                 685             


Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser 
    690                 695                 700                 


Val Lys Thr 
705         


<210>  11
<211>  3344
<212>  DNA
<213>  Xenopus tropicalis

<400>  11
agagcaggga agtacagcgc tgcgctacaa gaactgagca aacgagcaga aaagtacaca       60

ttcctgatcc ttcggtcttt ccaaaagtcc ccaatggggt cacacaggcc atggttactt      120

ggtgctgtgg tgctgctggc actccttcag gtacagggag gactggcaga atggacacag      180

tgtcaaatgg gattttccaa ggaaaggtac agcttttcgg tacctaagaa cttggagaca      240

gacaaagcac tgggtagagt gatctttaac agctgtgagg gaccagtgag aattcagttt      300

gcctctaaag atcctaattt tgaaattcac aaagatggca cagtttatgt taagaatcct      360

accaagatga aagacaacag aaaaacattc cgtgtcctgg cttgggagaa tcaaggtcat      420

gtatactcta ccagtgtaac cttgaaaggg gaagggcatc accataagca ggacatttct      480

tctgtgaaac attcccacca cccaaaatct gagactggtt taaaaagaca aaaaagagac      540

tgggtgattc caccaatcgt aacatctgag aatgaaaagg gcccatttcc caaacggctt      600

gtgcagatca agtccagtaa tgcaaaggaa atcaaggttt tttacagtat cacaggccag      660

ggtgccgata cccctccaga aggagtgttc actattggac gggaggatgg atggctaaat      720

gtgacacgac ctttggacag agaagccatt gatagttaca ctcttttttc tcatgctgtg      780

tcagtaaatg ggcaaaatgt ggaagatccc atggaaatcc aaattaaagt acaagatcag      840

aatgataatg acccagtttt cacacaggag gtctttgaag gctatgtgcc tgaagggtct      900

aagccaggta cgcccgtcat gactgtatct gcaacagatg ccgatgatgc tatagacatg      960

tacaatggtg tgattactta ctccattctc aaccaagacc ctaaagagcc caacaatcaa     1020

atgttcacta ttgattccca gtctgggttg atcagcgtag ttacaactgg attagacaga     1080

gagaaaatac cagtgtacac actgactatt caagctgcag atggagaatt tgggaaagat     1140

cgcacaacaa ctgcaaaagc tgtgatcatt gtgacagaca ccaatgataa ccctcctgtg     1200

tttaacccaa cgcaatacat tgcagaggtt cctgaaaatg aagttggata tgaggttgca     1260

cgtcttacgg taacagatgc agatattgaa gggtcagatg cctggaatgc tgtgtacaag     1320

atcattaaag gaaatgaggc tggctttttc agcatccaaa cagatattga caacattggg     1380

ctactgaaaa cagtgaaggg tctggactat gagctgaaga agcagtatat tctgtcagtc     1440

attgtgacaa acaaagctaa cttttctgtt ccactacaaa cttcaactgc aacggtcact     1500

gtaactgtca cagatgtgaa tgaggcccca gtatttgtac cagtgttgaa agacgtgtct     1560

gtgccagagg atctgcccag tggccaagtt gttgctacct ataccgcaca ggatccagac     1620

aaggaacaga accagaaaat aagttacttc attggaaatg acccagcagg gtgggtgtct     1680

gtgaacagag ataatgggat tgtcactgga aatggaaact tggatcggga atcaaagttt     1740

gtgctaaaca acacctacaa agtcataatc ttggccgctg acagtggcac tccttctgcc     1800

actgggactg gaacccttgt gcttaatctc attgatgtta atgataatgg cccatttttg     1860

gatccccaac aaaatagttt ctgccagaag gatccaggct ttcgtgtatt taatatcatt     1920

gacaaagatc tttaccctaa cacataccca tatacagtag acctgactgg tgaatccaat     1980

gaaaactgga ctgctacagt gacagaacag agtttacttg agctgagacc taaaaaggaa     2040

ctggatattg gacgatacga agttttgatc tcattgagag acaatcaggg actgacagat     2100

gtgacaaagc tacagattac aatctgtcaa tgtaatggtg accaaatgca atgtgaggaa     2160

aaggctgctc aagcaggagg tttggggata tcagccatag ttggaatcct tggagggatc     2220

ctagcgcttc ttttattgtt gttgctgctc ttactgtttg tacgacgaaa gaaagtggta     2280

aaagaacctt tattaccacc agaagatgag actcgggaca atgtattttt ctatgatgaa     2340

gaaggcggtg gtgaggaaga ccaggatttt gatctaagcc agcttcaccg tggtctagat     2400

gctcgtccag atataatccg taatgatgtc gttccagttt tagctgctcc ccagtatcga     2460

ccccgtcctg ccaatccaga tgaaattgga aatttcattg atgagaactt gcatgcagct     2520

gacaatgacc ccactgctcc tccatacgac tcgctccttg tgttcgatta cgaaggcagt     2580

ggctctgagg ccgcatcact cagctctctt aactcttcca actctgattt agatcaggat     2640

tacagtgctt tgaataactg gggacctcgt ttcaccaaac tggcagaaat gtatggagga     2700

gatgaggatt agaatgtgca ctgcaatacc attttgattc taaacagtaa actaaaaacc     2760

ataattgtgt atgcagtctt tggaattcac tttgttttct cctgctctta aaacagagat     2820

aaggactgct caaaagttac tcctcctgct tttgtaaaat cgttcaaaaa tattttatgt     2880

atatgtatat atgaaaaaat cgtatttttt gtactatttg tgttcttata tccctgcaat     2940

ttgtaataca agaggatctt tatctgctta attataaata taaaatgccc gatatgattc     3000

actatgattt taatgtgttg agaaatcttt ttttaaaaag gtttccagac acctgacgct     3060

tggaagggaa ttccataaaa atataattga attgggggga gattgtgttt tgccatggtc     3120

tgatatacat tttcatatat atacatatga tcattcacag agtacagtca acatttggaa     3180

tttgatgagc ttgctggtcg aactgaaaaa aaaatgtatt atagctgggg taaaaattaa     3240

tgtatgagct aaatggggca caattttgat atctctgcat ttgtatttta cttggcatgt     3300

atacttttgt aataaaataa agatatacat taatatacaa cata                      3344


<210>  12
<211>  872
<212>  PRT
<213>  Xenopus tropicalis

<400>  12

Met Gly Ser His Arg Pro Trp Leu Leu Gly Ala Val Val Leu Leu Ala 
1               5                   10                  15      


Leu Leu Gln Val Gln Gly Gly Leu Ala Glu Trp Thr Gln Cys Gln Met 
            20                  25                  30          


Gly Phe Ser Lys Glu Arg Tyr Ser Phe Ser Val Pro Lys Asn Leu Glu 
        35                  40                  45              


Thr Asp Lys Ala Leu Gly Arg Val Ile Phe Asn Ser Cys Glu Gly Pro 
    50                  55                  60                  


Val Arg Ile Gln Phe Ala Ser Lys Asp Pro Asn Phe Glu Ile His Lys 
65                  70                  75                  80  


Asp Gly Thr Val Tyr Val Lys Asn Pro Thr Lys Met Lys Asp Asn Arg 
                85                  90                  95      


Lys Thr Phe Arg Val Leu Ala Trp Glu Asn Gln Gly His Val Tyr Ser 
            100                 105                 110         


Thr Ser Val Thr Leu Lys Gly Glu Gly His His His Lys Gln Asp Ile 
        115                 120                 125             


Ser Ser Val Lys His Ser His His Pro Lys Ser Glu Thr Gly Leu Lys 
    130                 135                 140                 


Arg Gln Lys Arg Asp Trp Val Ile Pro Pro Ile Val Thr Ser Glu Asn 
145                 150                 155                 160 


Glu Lys Gly Pro Phe Pro Lys Arg Leu Val Gln Ile Lys Ser Ser Asn 
                165                 170                 175     


Ala Lys Glu Ile Lys Val Phe Tyr Ser Ile Thr Gly Gln Gly Ala Asp 
            180                 185                 190         


Thr Pro Pro Glu Gly Val Phe Thr Ile Gly Arg Glu Asp Gly Trp Leu 
        195                 200                 205             


Asn Val Thr Arg Pro Leu Asp Arg Glu Ala Ile Asp Ser Tyr Thr Leu 
    210                 215                 220                 


Phe Ser His Ala Val Ser Val Asn Gly Gln Asn Val Glu Asp Pro Met 
225                 230                 235                 240 


Glu Ile Gln Ile Lys Val Gln Asp Gln Asn Asp Asn Asp Pro Val Phe 
                245                 250                 255     


Thr Gln Glu Val Phe Glu Gly Tyr Val Pro Glu Gly Ser Lys Pro Gly 
            260                 265                 270         


Thr Pro Val Met Thr Val Ser Ala Thr Asp Ala Asp Asp Ala Ile Asp 
        275                 280                 285             


Met Tyr Asn Gly Val Ile Thr Tyr Ser Ile Leu Asn Gln Asp Pro Lys 
    290                 295                 300                 


Glu Pro Asn Asn Gln Met Phe Thr Ile Asp Ser Gln Ser Gly Leu Ile 
305                 310                 315                 320 


Ser Val Val Thr Thr Gly Leu Asp Arg Glu Lys Ile Pro Val Tyr Thr 
                325                 330                 335     


Leu Thr Ile Gln Ala Ala Asp Gly Glu Phe Gly Lys Asp Arg Thr Thr 
            340                 345                 350         


Thr Ala Lys Ala Val Ile Ile Val Thr Asp Thr Asn Asp Asn Pro Pro 
        355                 360                 365             


Val Phe Asn Pro Thr Gln Tyr Ile Ala Glu Val Pro Glu Asn Glu Val 
    370                 375                 380                 


Gly Tyr Glu Val Ala Arg Leu Thr Val Thr Asp Ala Asp Ile Glu Gly 
385                 390                 395                 400 


Ser Asp Ala Trp Asn Ala Val Tyr Lys Ile Ile Lys Gly Asn Glu Ala 
                405                 410                 415     


Gly Phe Phe Ser Ile Gln Thr Asp Ile Asp Asn Ile Gly Leu Leu Lys 
            420                 425                 430         


Thr Val Lys Gly Leu Asp Tyr Glu Leu Lys Lys Gln Tyr Ile Leu Ser 
        435                 440                 445             


Val Ile Val Thr Asn Lys Ala Asn Phe Ser Val Pro Leu Gln Thr Ser 
    450                 455                 460                 


Thr Ala Thr Val Thr Val Thr Val Thr Asp Val Asn Glu Ala Pro Val 
465                 470                 475                 480 


Phe Val Pro Val Leu Lys Asp Val Ser Val Pro Glu Asp Leu Pro Ser 
                485                 490                 495     


Gly Gln Val Val Ala Thr Tyr Thr Ala Gln Asp Pro Asp Lys Glu Gln 
            500                 505                 510         


Asn Gln Lys Ile Ser Tyr Phe Ile Gly Asn Asp Pro Ala Gly Trp Val 
        515                 520                 525             


Ser Val Asn Arg Asp Asn Gly Ile Val Thr Gly Asn Gly Asn Leu Asp 
    530                 535                 540                 


Arg Glu Ser Lys Phe Val Leu Asn Asn Thr Tyr Lys Val Ile Ile Leu 
545                 550                 555                 560 


Ala Ala Asp Ser Gly Thr Pro Ser Ala Thr Gly Thr Gly Thr Leu Val 
                565                 570                 575     


Leu Asn Leu Ile Asp Val Asn Asp Asn Gly Pro Phe Leu Asp Pro Gln 
            580                 585                 590         


Gln Asn Ser Phe Cys Gln Lys Asp Pro Gly Phe Arg Val Phe Asn Ile 
        595                 600                 605             


Ile Asp Lys Asp Leu Tyr Pro Asn Thr Tyr Pro Tyr Thr Val Asp Leu 
    610                 615                 620                 


Thr Gly Glu Ser Asn Glu Asn Trp Thr Ala Thr Val Thr Glu Gln Ser 
625                 630                 635                 640 


Leu Leu Glu Leu Arg Pro Lys Lys Glu Leu Asp Ile Gly Arg Tyr Glu 
                645                 650                 655     


Val Leu Ile Ser Leu Arg Asp Asn Gln Gly Leu Thr Asp Val Thr Lys 
            660                 665                 670         


Leu Gln Ile Thr Ile Cys Gln Cys Asn Gly Asp Gln Met Gln Cys Glu 
        675                 680                 685             


Glu Lys Ala Ala Gln Ala Gly Gly Leu Gly Ile Ser Ala Ile Val Gly 
    690                 695                 700                 


Ile Leu Gly Gly Ile Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Phe Val Arg Arg Lys Lys Val Val Lys Glu Pro Leu Leu Pro Pro 
                725                 730                 735     


Glu Asp Glu Thr Arg Asp Asn Val Phe Phe Tyr Asp Glu Glu Gly Gly 
            740                 745                 750         


Gly Glu Glu Asp Gln Asp Phe Asp Leu Ser Gln Leu His Arg Gly Leu 
        755                 760                 765             


Asp Ala Arg Pro Asp Ile Ile Arg Asn Asp Val Val Pro Val Leu Ala 
    770                 775                 780                 


Ala Pro Gln Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn 
785                 790                 795                 800 


Phe Ile Asp Glu Asn Leu His Ala Ala Asp Asn Asp Pro Thr Ala Pro 
                805                 810                 815     


Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu 
            820                 825                 830         


Ala Ala Ser Leu Ser Ser Leu Asn Ser Ser Asn Ser Asp Leu Asp Gln 
        835                 840                 845             


Asp Tyr Ser Ala Leu Asn Asn Trp Gly Pro Arg Phe Thr Lys Leu Ala 
    850                 855                 860                 


Glu Met Tyr Gly Gly Asp Glu Asp 
865                 870         


<210>  13
<211>  1862
<212>  DNA
<213>  Homo sapiens

<400>  13
gtccccgcgc cagagacgca gccgcgctcc caccacccac acccaccgcg ccctcgttcg       60

cctcttctcc gggagccagt ccgcgccacc gccgccgccc aggccatcgc caccctccgc      120

agccatgtcc accaggtccg tgtcctcgtc ctcctaccgc aggatgttcg gcggcccggg      180

caccgcgagc cggccgagct ccagccggag ctacgtgact acgtccaccc gcacctacag      240

cctgggcagc gcgctgcgcc ccagcaccag ccgcagcctc tacgcctcgt ccccgggcgg      300

cgtgtatgcc acgcgctcct ctgccgtgcg cctgcggagc agcgtgcccg gggtgcggct      360

cctgcaggac tcggtggact tctcgctggc cgacgccatc aacaccgagt tcaagaacac      420

ccgcaccaac gagaaggtgg agctgcagga gctgaatgac cgcttcgcca actacatcga      480

caaggtgcgc ttcctggagc agcagaataa gatcctgctg gccgagctcg agcagctcaa      540

gggccaaggc aagtcgcgcc tgggggacct ctacgaggag gagatgcggg agctgcgccg      600

gcaggtggac cagctaacca acgacaaagc ccgcgtcgag gtggagcgcg acaacctggc      660

cgaggacatc atgcgcctcc gggagaaatt gcaggaggag atgcttcaga gagaggaagc      720

cgaaaacacc ctgcaatctt tcagacagga tgttgacaat gcgtctctgg cacgtcttga      780

ccttgaacgc aaagtggaat ctttgcaaga agagattgcc tttttgaaga aactccacga      840

agaggaaatc caggagctgc aggctcagat tcaggaacag catgtccaaa tcgatgtgga      900

tgtttccaag cctgacctca cggctgccct gcgtgacgta cgtcagcaat atgaaagtgt      960

ggctgccaag aacctgcagg aggcagaaga atggtacaaa tccaagtttg ctgacctctc     1020

tgaggctgcc aaccggaaca atgacgccct gcgccaggca aagcaggagt ccactgagta     1080

ccggagacag gtgcagtccc tcacctgtga agtggatgcc cttaaaggaa ccaatgagtc     1140

cctggaacgc cagatgcgtg aaatggaaga gaactttgcc gttgaagctg ctaactacca     1200

agacactatt ggccgcctgc aggatgagat tcagaatatg aaggaggaaa tggctcgtca     1260

ccttcgtgaa taccaagacc tgctcaatgt taagatggcc cttgacattg agattgccac     1320

ctacaggaag ctgctggaag gcgaggagag caggatttct ctgcctcttc caaacttttc     1380

ctccctgaac ctgagggaaa ctaatctgga ttcactccct ctggttgata cccactcaaa     1440

aaggacactt ctgattaaga cggttgaaac tagagatgga caggttatca acgaaacttc     1500

tcagcatcac gatgaccttg aataaaaatt gcacacactc agtgcagcaa tatattacca     1560

gcaagaataa aaaagaaatc catatcttaa agaaacagct ttcaagtgcc tttctgcagt     1620

ttttcaggag cgcaagatag atttggaata ggaataagct ctagttctta acaaccgaca     1680

ctcctacaag atttagaaaa aagtttacaa cataatctag tttacagaaa aatcttgtgc     1740

tagaatactt tttaaaaggt attttgaata ccattaaaac tgcttttttt tttccagcaa     1800

gtatccaacc aacttggttc tgcttcaata aatctttgga aaaactcaaa aaaaaaaaaa     1860

aa                                                                    1862


<210>  14
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  15
<211>  2721
<212>  DNA
<213>  Homo sapiens

<400>  15
atgtgccgga tagcgggagc gctgcggacc ctgctgccgc tgctggcggc cctgcttcag       60

gcgtctgtag aggcttctgg tgaaatcgca ttatgcaaga ctggatttcc tgaagatgtt      120

tacagtgcag tcttatcgaa ggatgtgcat gaaggacagc ctcttctcaa tgtgaagttt      180

agcaactgca atggaaaaag aaaagtacaa tatgagagca gtgagcctgc agattttaag      240

gtggatgaag atggcatggt gtatgccgtg agaagctttc cactctcttc tgagcatgcc      300

aagttcctga tatatgccca agacaaagag acccaggaaa agtggcaagt ggcagtaaaa      360

ttgagcctga agccaacctt aactgaggag tcagtgaagg agtcagcaga agttgaagaa      420

atagtgttcc caagacaatt cagtaagcac agtggccacc tacaaaggca gaagagagac      480

tgggtcatcc ctccaatcaa cttgccagaa aactccaggg gaccttttcc tcaagagctt      540

gtcaggatca ggtctgatag agataaaaac ctttcactgc ggtacagtgt aactgggcca      600

ggagctgacc agcctccaac tggtatcttc attatcaacc ccatctcggg tcagctgtcg      660

gtgacaaagc ccctggatcg cgagcagata gcccggtttc atttgagggc acatgcagta      720

gatattaatg gaaatcaagt ggagaacccc attgacattg tcatcaatgt tattgacatg      780

aatgacaaca gacctgagtt cttacaccag gtttggaatg ggacagttcc tgagggatca      840

aagcctggaa catatgtgat gaccgtaaca gcaattgatg ctgacgatcc caatgccctc      900

aatgggatgt tgaggtacag aatcgtgtct caggctccaa gcaccccttc acccaacatg      960

tttacaatca acaatgagac tggtgacatc atcacagtgg cagctggact tgatcgagaa     1020

aaagtgcaac agtatacgtt aataattcaa gctacagaca tggaaggcaa tcccacatat     1080

ggcctttcaa acacagccac ggccgtcatc acagtgacag atgtcaatga caatcctcca     1140

gagtttactg ccatgacgtt ttatggtgaa gttcctgaga acagggtaga catcatagta     1200

gctaatctaa ctgtgaccga taaggatcaa ccccatacac cagcctggaa cgcagtgtac     1260

agaatcagtg gcggagatcc tactggacgg ttcgccatcc agaccgaccc aaacagcaac     1320

gacgggttag tcaccgtggt caaaccaatc gactttgaaa caaataggat gtttgtcctt     1380

actgttgctg cagaaaatca agtgccatta gccaagggaa ttcagcaccc ccctcagtca     1440

actgcaaccg tgtctgttac agttattgac gtaaatgaaa acccttattt tgcccccaat     1500

cctaagatca ttcgccaaga agaagggctt catgccggta ccatgttgac aacattcact     1560

gctcaggacc cagatcgata tatgcagcaa aatattagat acactaaatt atctgatcct     1620

gccaattggc taaaaataga tcctgtgaat ggacaaataa ctacaattgc tgttttggac     1680

cgagaatcac caaatgtgaa aaacaatata tataatgcta ctttccttgc ttctgacaat     1740

ggaattcctc ctatgagtgg aacaggaacg ctgcagatct atttacttga tattaatgac     1800

aatgcccctc aagtgttacc tcaagaggca gagacttgcg aaactccaga ccccaattca     1860

attaatatta cagcacttga ttatgacatt gatccaaatg ctggaccatt tgcttttgat     1920

cttcctttat ctccagtgac tattaagaga aattggacca tcactcggct taatggtgat     1980

tttgctcagc ttaatttaaa gataaaattt cttgaagctg gtatctatga agttcccatc     2040

ataatcacag attcgggtaa tcctcccaaa tcaaatattt ccatcctgcg tgtgaaggtt     2100

tgccagtgtg actccaacgg ggactgcaca gatgtggaca ggattgtggg tgcggggctt     2160

ggcaccggtg ccatcattgc catcctgctc tgcatcatca tcctgcttat ccttgtgctg     2220

atgtttgtgg tatggatgaa acgccgggat aaagaacgcc aggccaaaca acttttaatt     2280

gatccagaag atgatgtaag agataatatt ttaaaatatg atgaagaagg tggaggagaa     2340

gaagaccagg actatgactt gagccagctg cagcagcctg acactgtgga gcctgatgcc     2400

atcaagcctg tgggaatccg acgaatggat gaaagaccca tccacgccga gccccagtat     2460

ccggtccgat ctgcagcccc acaccctgga gacattgggg acttcattaa tgagggcctt     2520

aaagcggctg acaatgaccc cacagctcca ccatatgact ccctgttagt gtttgactat     2580

gaaggcagtg gctccactgc tgggtccttg agctccctta attcctcaag tagtggtggt     2640

gagcaggact atgattacct gaacgactgg gggccacggt tcaagaaact tgctgacatg     2700

tatggtggag gtgatgactg a                                               2721


<210>  16
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Ala 
1               5                   10                  15      


Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
            20                  25                  30          


Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
        35                  40                  45              


Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
    50                  55                  60                  


Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
65                  70                  75                  80  


Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                85                  90                  95      


Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
            100                 105                 110         


Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
        115                 120                 125             


Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
    130                 135                 140                 


Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
145                 150                 155                 160 


Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                165                 170                 175     


Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
            180                 185                 190         


Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
        195                 200                 205             


Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
    210                 215                 220                 


Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
225                 230                 235                 240 


Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                245                 250                 255     


Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
            260                 265                 270         


Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
        275                 280                 285             


Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
    290                 295                 300                 


Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
305                 310                 315                 320 


Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                325                 330                 335     


Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
            340                 345                 350         


Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
        355                 360                 365             


Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
    370                 375                 380                 


Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
385                 390                 395                 400 


Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                405                 410                 415     


Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
            420                 425                 430         


Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
        435                 440                 445             


Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
    450                 455                 460                 


Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
465                 470                 475                 480 


Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                485                 490                 495     


Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
            500                 505                 510         


Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
        515                 520                 525             


Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
    530                 535                 540                 


Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
545                 550                 555                 560 


Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                565                 570                 575     


Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
            580                 585                 590         


Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
        595                 600                 605             


Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
    610                 615                 620                 


Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
625                 630                 635                 640 


Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                645                 650                 655     


Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
            660                 665                 670         


Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
        675                 680                 685             


Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
    690                 695                 700                 


Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
705                 710                 715                 720 


Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                725                 730                 735     


Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
            740                 745                 750         


Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
        755                 760                 765             


Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
    770                 775                 780                 


Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
785                 790                 795                 800 


Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                805                 810                 815     


Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
            820                 825                 830         


Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
        835                 840                 845             


Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
    850                 855                 860                 


Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
865                 870                 875                 880 


Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                885                 890                 895     


Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
            900                 905     


<210>  17
<211>  2391
<212>  DNA
<213>  Homo sapiens

<400>  17
atgaaggaga actactgttt acaagccgcc ctggtgtgcc tgggcatgct gtgccacagc       60

catgcctttg ccccagagcg gcgggggcac ctgcggccct ccttccatgg gcaccatgag      120

aagggcaagg aggggcaggt gctacagcgc tccaagcgtg gctgggtctg gaaccagttc      180

ttcgtgatag aggagtacac cgggcctgac cccgtgcttg tgggcaggct tcattcagat      240

attgactctg gtgatgggaa cattaaatac attctctcag gggaaggagc tggaaccatt      300

tttgtgattg atgacaaatc agggaacatt catgccacca agacgttgga tcgagaagag      360

agagcccagt acacgttgat ggctcaggcg gtggacaggg acaccaatcg gccactggag      420

ccaccgtcgg aattcattgt caaggtccag gacattaatg acaaccctcc ggagttcctg      480

cacgagacct atcatgccaa cgtgcctgag aggtccaatg tgggaacgtc agtaatccag      540

gtgacagctt cagatgcaga tgaccccact tatggaaata gcgccaagtt agtgtacagt      600

atcctcgaag gacaacccta tttttcggtg gaagcacaga caggtatcat cagaacagcc      660

ctacccaaca tggacaggga ggccaaggag gagtaccacg tggtgatcca ggccaaggac      720

atgggtggac atatgggcgg actctcaggg acaaccaaag tgacgatcac actgaccgat      780

gtcaatgaca acccaccaaa gtttccgcag agcgtatacc agatgtctgt gtcagaagca      840

gccgtccctg gggaggaagt aggaagagtg aaagctaaag atccagacat tggagaaaat      900

ggcttagtca catacaatat tgttgatgga gatggtatgg aatcgtttga aatcacaacg      960

gactatgaaa cacaggaggg ggtgataaag ctgaaaaagc ctgtagattt tgaaaccaaa     1020

agagcctata gcttgaaggt agaggcagcc aacgtgcaca tcgacccgaa gtttatcagc     1080

aatggccctt tcaaggacac tgtgaccgtc aagatctcag tagaagatgc tgatgagccc     1140

cctatgttct tggccccaag ttacatccac gaagtccaag aaaatgcagc tgctggcacc     1200

gtggttggga gagtgcatgc caaagaccct gatgctgcca acagcccgat aaggtattcc     1260

atcgatcgtc acactgacct cgacagattt ttcactatta atccagagga tggttttatt     1320

aaaactacaa aacctctgga tagagaggaa acagcctggc tcaacatcac tgtctttgca     1380

gcagaaatcc acaatcggca tcaggaagcc aaagtcccag tggccattag ggtccttgat     1440

gtcaacgata atgctcccaa gtttgctgcc ccttatgaag gtttcatctg tgagagtgat     1500

cagaccaagc cactttccaa ccagccaatt gttacaatta gtgcagatga caaggatgac     1560

acggccaatg gaccaagatt tatcttcagc ctaccccctg aaatcattca caatccaaat     1620

ttcacagtca gagacaaccg agataacaca gcaggcgtgt acgcccggcg tggagggttc     1680

agtcggcaga agcaggactt gtaccttctg cccatagtga tcagcgatgg cggcatcccg     1740

cccatgagta gcaccaacac cctcaccatc aaagtctgcg ggtgcgacgt gaacggggca     1800

ctgctctcct gcaacgcaga ggcctacatt ctgaacgccg gcctgagcac aggcgccctg     1860

atcgccatcc tcgcctgcat cgtcattctc ctggtcattg tagtattgtt tgtgaccctg     1920

agaaggcaaa agaaagaacc actcattgtc tttgaggaag aagatgtccg tgagaacatc     1980

attacttatg atgatgaagg gggtggggaa gaagacacag aagcctttga tattgccacc     2040

ctccagaatc ctgatggtat caatggattt atcccccgca aagacatcaa acctgagtat     2100

cagtacatgc ctagacctgg gctccggcca gcgcccaaca gcgtggatgt cgatgacttc     2160

atcaacacga gaatacagga ggcagacaat gaccccacgg ctcctcctta tgactccatt     2220

caaatctacg gttatgaagg caggggctca gtggccgggt ccctgagctc cctagagtcg     2280

gccaccacag attcagactt ggactatgat tatctacaga actggggacc tcgttttaag     2340

aaactagcag atttgtatgg ttccaaagac acttttgatg acgattctta a              2391


<210>  18
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Val Ile Val Val Leu Phe Val Thr Leu 
625                 630                 635                 640 


Arg Arg Gln Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu Asp Val 
                645                 650                 655     


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
            660                 665                 670         


Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly Ile Asn 
        675                 680                 685             


Gly Phe Ile Pro Arg Lys Asp Ile Lys Pro Glu Tyr Gln Tyr Met Pro 
    690                 695                 700                 


Arg Pro Gly Leu Arg Pro Ala Pro Asn Ser Val Asp Val Asp Asp Phe 
705                 710                 715                 720 


Ile Asn Thr Arg Ile Gln Glu Ala Asp Asn Asp Pro Thr Ala Pro Pro 
                725                 730                 735     


Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser Val Ala 
            740                 745                 750         


Gly Ser Leu Ser Ser Leu Glu Ser Ala Thr Thr Asp Ser Asp Leu Asp 
        755                 760                 765             


Tyr Asp Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp 
    770                 775                 780                 


Leu Tyr Gly Ser Lys Asp Thr Phe Asp Asp Asp Ser 
785                 790                 795     


<210>  19
<211>  2598
<212>  DNA
<213>  Homo sapiens

<400>  19
atggccctcg tactcggctc cctgttgctg ctggggctgt gcgggaactc cttttcagga       60

gggcagcctt catccacaga tgctcctaag gcttggaatt atgaattgcc tgcaacaaat      120

tatgagaccc aagactccca taaagctgga cccattggca ttctctttga actagtgcat      180

atctttctct atgtggtaca gccgcgtgat ttcccagaag atactttgag aaaattctta      240

cagaaggcat atgaatccaa aattgattat gacaagccag aaactgtaat cttaggtcta      300

aagattgtct actatgaagc agggattatt ctatgctgtg tcctggggct gctgtttatt      360

attctgatgc ctctggtggg gtatttcttt tgtatgtgtc gttgctgtaa caaatgtggt      420

ggagaaatgc accagcgaca gaaggaaaat gggcccttcc tgaggaaatg ctttgcaatc      480

tccctgttgg tgatttgtat aataataagc attggcatct tctatggttt tgtggcaaat      540

caccaggtaa gaacccggat caaaaggagt cggaaactgg cagatagcaa tttcaaggac      600

ttgcgaactc tcttgaatga aactccagag caaatcaaat atatattggc ccagtacaac      660

actaccaagg acaaggcgtt cacagatctg aacagtatca attcagtgct aggaggcgga      720

attcttgacc gactgagacc caacatcatc cctgttcttg atgagattaa gtccatggca      780

acagcgatca aggagaccaa agaggcgttg gagaacatga acagcacctt gaagagcttg      840

caccaacaaa gtacacagct tagcagcagt ctgaccagcg tgaaaactag cctgcggtca      900

tctctcaatg accctctgtg cttggtgcat ccatcaagtg aaacctgcaa cagcatcaga      960

ttgtctctaa gccagctgaa tagcaaccct gaactgaggc agcttccacc cgtggatgca     1020

gaacttgaca acgttaataa cgttcttagg acagatttgg atggcctggt ccaacagggc     1080

tatcaatccc ttaatgatat acctgacaga gtacaacgcc aaaccacgac tgtcgtagca     1140

ggtatcaaaa gggtcttgaa ttccattggt tcagatatcg acaatgtaac tcagcgtctt     1200

cctattcagg atatactctc agcattctct gtttatgtta ataacactga aagttacatc     1260

cacagaaatt tacctacatt ggaagagtat gattcatact ggtggctggg tggcctggtc     1320

atctgctctc tgctgaccct catcgtgatt ttttactacc tgggcttact gtgtggcgtg     1380

tgcggctatg acaggcatgc caccccgacc acccgaggct gtgtctccaa caccggaggc     1440

gtcttcctca tggttggagt tggattaagt ttcctctttt gctggatatt gatgatcatt     1500

gtggttctta cctttgtctt tggtgcaaat gtggaaaaac tgatctgtga accttacacg     1560

agcaaggaat tattccgggt tttggataca ccctacttac taaatgaaga ctgggaatac     1620

tatctctctg ggaagctatt taataaatca aaaatgaagc tcacttttga acaagtttac     1680

agtgactgca aaaaaaatag aggcacttac ggcactcttc acctgcagaa cagcttcaat     1740

atcagtgaac atctcaacat taatgagcat actggaagca taagcagtga attggaaagt     1800

ctgaaggtaa atcttaatat ctttctgttg ggtgcagcag gaagaaaaaa ccttcaggat     1860

tttgctgctt gtggaataga cagaatgaat tatgacagct acttggctca gactggtaaa     1920

tcccccgcag gagtgaatct tttatcattt gcatatgatc tagaagcaaa agcaaacagt     1980

ttgcccccag gaaatttgag gaactccctg aaaagagatg cacaaactat taaaacaatt     2040

caccagcaac gagtccttcc tatagaacaa tcactgagca ctctatacca aagcgtcaag     2100

atacttcaac gcacagggaa tggattgttg gagagagtaa ctaggattct agcttctctg     2160

gattttgctc agaacttcat cacaaacaat acttcctctg ttattattga ggaaactaag     2220

aagtatggga gaacaataat aggatatttt gaacattatc tgcagtggat cgagttctct     2280

atcagtgaga aagtggcatc gtgcaaacct gtggccaccg ctctagatac tgctgttgat     2340

gtctttctgt gtagctacat tatcgacccc ttgaatttgt tttggtttgg cataggaaaa     2400

gctactgtat ttttacttcc ggctctaatt tttgcggtaa aactggctaa gtactatcgt     2460

cgaatggatt cggaggacgt gtacgatgat gttgaaacta tacccatgaa aaatatggaa     2520

aatggtaata atggttatca taaagatcat gtatatggta ttcacaatcc tgttatgaca     2580

agcccatcac aacattga                                                   2598


<210>  20
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  21
<211>  2466
<212>  DNA
<213>  Homo sapiens

<400>  21
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg       60

gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc      120

aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg      180

cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg      240

cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga      300

gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc      360

atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg      420

gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa      480

aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca      540

gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag      600

gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt      660

gtggtcccat ctgacaaggg aaattatacc tgtgtagtgg agaatgaata cgggtccatc      720

aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc      780

ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt      840

tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa      900

tacgggcccg acgggctgcc ctacctcaag gttctcaagg ccgccggtgt taacaccacg      960

gacaaagaga ttgaggttct ctatattcgg aatgtaactt ttgaggacgc tggggaatat     1020

acgtgcttgg cgggtaattc tattgggata tcctttcact ctgcatggtt gacagttctg     1080

ccagcgcctg gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt     1140

tactgcatag gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg     1200

aagaacacga ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa     1260

cgtatccccc tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc     1320

aacaccccgc tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg     1380

gcaggggtct ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag     1440

ctgacactgg gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca     1500

gtgggaattg acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa     1560

gatgatgcca cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg     1620

attgggaaac acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc     1680

tatgtcatag ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg     1740

ccacccggga tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc     1800

aaggacttgg tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa     1860

aaatgtattc atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg     1920

aaaatagcag actttggact cgccagagat atcaacaata tagactatta caaaaagacc     1980

accaatgggc ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac     2040

actcatcaga gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg     2100

ggctcgccct acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac     2160

agaatggata agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg     2220

catgcagtgc cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt     2280

ctcactctca caaccaatga ggaatacttg gacctcagcc aacctctcga acagtattca     2340

cctagttacc ctgacacaag aagttcttgt tcttcaggag atgattctgt tttttctcca     2400

gaccccatgc cttacgaacc atgccttcct cagtatccac acataaacgg cagtgttaaa     2460

acatga                                                                2466


<210>  22
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  23
<211>  2649
<212>  DNA
<213>  Homo sapiens

<400>  23
atgggccctt ggagccgcag cctctcggcg ctgctgctgc tgctgcaggt ctcctcttgg       60

ctctgccagg agccggagcc ctgccaccct ggctttgacg ccgagagcta cacgttcacg      120

gtgccccggc gccacctgga gagaggccgc gtcctgggca gagtgaattt tgaagattgc      180

accggtcgac aaaggacagc ctatttttcc ctcgacaccc gattcaaagt gggcacagat      240

ggtgtgatta cagtcaaaag gcctctacgg tttcataacc cacagatcca tttcttggtc      300

tacgcctggg actccaccta cagaaagttt tccaccaaag tcacgctgaa tacagtgggg      360

caccaccacc gccccccgcc ccatcaggcc tccgtttctg gaatccaagc agaattgctc      420

acatttccca actcctctcc tggcctcaga agacagaaga gagactgggt tattcctccc      480

atcagctgcc cagaaaatga aaaaggccca tttcctaaaa acctggttca gatcaaatcc      540

aacaaagaca aagaaggcaa ggttttctac agcatcactg gccaaggagc tgacacaccc      600

cctgttggtg tctttattat tgaaagagaa acaggatggc tgaaggtgac agagcctctg      660

gatagagaac gcattgccac atacactctc ttctctcacg ctgtgtcatc caacgggaat      720

gcagttgagg atccaatgga gattttgatc acggtaaccg atcagaatga caacaagccc      780

gaattcaccc aggaggtctt taaggggtct gtcatggaag gtgctcttcc aggaacctct      840

gtgatggagg tcacagccac agacgcggac gatgatgtga acacctacaa tgccgccatc      900

gcttacacca tcctcagcca agatcctgag ctccctgaca aaaatatgtt caccattaac      960

aggaacacag gagtcatcag tgtggtcacc actgggctgg accgagagag tttccctacg     1020

tataccctgg tggttcaagc tgctgacctt caaggtgagg ggttaagcac aacagcaaca     1080

gctgtgatca cagtcactga caccaacgat aatcctccga tcttcaatcc caccacgtac     1140

aagggtcagg tgcctgagaa cgaggctaac gtcgtaatca ccacactgaa agtgactgat     1200

gctgatgccc ccaatacccc agcgtgggag gctgtataca ccatattgaa tgatgatggt     1260

ggacaatttg tcgtcaccac aaatccagtg aacaacgatg gcattttgaa aacagcaaag     1320

ggcttggatt ttgaggccaa gcagcagtac attctacacg tagcagtgac gaatgtggta     1380

ccttttgagg tctctctcac cacctccaca gccaccgtca ccgtggatgt gctggatgtg     1440

aatgaagccc ccatctttgt gcctcctgaa aagagagtgg aagtgtccga ggactttggc     1500

gtgggccagg aaatcacatc ctacactgcc caggagccag acacatttat ggaacagaaa     1560

ataacatatc ggatttggag agacactgcc aactggctgg agattaatcc ggacactggt     1620

gccatttcca ctcgggctga gctggacagg gaggattttg agcacgtgaa gaacagcacg     1680

tacacagccc taatcatagc tacagacaat ggttctccag ttgctactgg aacagggaca     1740

cttctgctga tcctgtctga tgtgaatgac aacgccccca taccagaacc tcgaactata     1800

ttcttctgtg agaggaatcc aaagcctcag gtcataaaca tcattgatgc agaccttcct     1860

cccaatacat ctcccttcac agcagaacta acacacgggg cgagtgccaa ctggaccatt     1920

cagtacaacg acccaaccca agaatctatc attttgaagc caaagatggc cttagaggtg     1980

ggtgactaca aaatcaatct caagctcatg gataaccaga ataaagacca agtgaccacc     2040

ttagaggtca gcgtgtgtga ctgtgaaggg gccgctggcg tctgtaggaa ggcacagcct     2100

gtcgaagcag gattgcaaat tcctgccatt ctggggattc ttggaggaat tcttgctttg     2160

ctaattctga ttctgctgct cttgctgttt cttcggagga gagcggtggt caaagagccc     2220

ttactgcccc cagaggatga cacccgggac aacgtttatt actatgatga agaaggaggc     2280

ggagaagagg accaggactt tgacttgagc cagctgcaca ggggcctgga cgctcggcct     2340

gaagtgactc gtaacgacgt tgcaccaacc ctcatgagtg tcccccggta tcttccccgc     2400

cctgccaatc ccgatgaaat tggaaatttt attgatgaaa atctgaaagc ggctgatact     2460

gaccccacag ccccgcctta tgattctctg ctcgtgtttg actatgaagg aagcggttcc     2520

gaagctgcta gtctgagctc cctgaactcc tcagagtcag acaaagacca ggactatgac     2580

tacttgaacg aatggggcaa tcgcttcaag aagctggctg acatgtacgg aggcggcgag     2640

gacgactag                                                             2649


<210>  24
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


