                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  METHODS AND COMPOSITIONS USING FGF23 FUSION POLYPEPTIDES

<130>  54067-US-NP

<160>  73    

<170>  PatentIn version 3.3

<210>  1
<211>  5003
<212>  DNA
<213>  Homo Sapiens

<400>  1
cgcgcagcat gcccgccagc gccccgccgc gccgcccgcg gccgccgccg ccgtcgctgt     60

cgctgctgct ggtgctgctg ggcctgggcg gccgccgcct gcgtgcggag ccgggcgacg    120

gcgcgcagac ctgggcccgt ttctcgcggc ctcctgcccc cgaggccgcg ggcctcttcc    180

agggcacctt ccccgacggc ttcctctggg ccgtgggcag cgccgcctac cagaccgagg    240

gcggctggca gcagcacggc aagggtgcgt ccatctggga tacgttcacc caccaccccc    300

tggcaccccc gggagactcc cggaacgcca gtctgccgtt gggcgccccg tcgccgctgc    360

agcccgccac cggggacgta gccagcgaca gctacaacaa cgtcttccgc gacacggagg    420

cgctgcgcga gctcggggtc actcactacc gcttctccat ctcgtgggcg cgagtgctcc    480

ccaatggcag cgcgggcgtc cccaaccgcg aggggctgcg ctactaccgg cgcctgctgg    540

agcggctgcg ggagctgggc gtgcagcccg tggtcaccct gtaccactgg gacctgcccc    600

agcgcctgca ggacgcctac ggcggctggg ccaaccgcgc cctggccgac cacttcaggg    660

attacgcgga gctctgcttc cgccacttcg gcggtcaggt caagtactgg atcaccatcg    720

acaaccccta cgtggtggcc tggcacggct acgccaccgg gcgcctggcc cccggcatcc    780

ggggcagccc gcggctcggg tacctggtgg cgcacaacct cctcctggct catgccaaag    840

tctggcatct ctacaatact tctttccgtc ccactcaggg aggtcaggtg tccattgccc    900

taagctctca ctggatcaat cctcgaagaa tgaccgacca cagcatcaaa gaatgtcaaa    960

aatctctgga ctttgtacta ggttggtttg ccaaacccgt atttattgat ggtgactatc   1020

ccgagagcat gaagaataac ctttcatcta ttctgcctga ttttactgaa tctgagaaaa   1080

agttcatcaa aggaactgct gacttttttg ctctttgctt tggacccacc ttgagttttc   1140

aacttttgga ccctcacatg aagttccgcc aattggaatc tcccaacctg aggcaactgc   1200

tttcctggat tgaccttgaa tttaaccatc ctcaaatatt tattgtggaa aatggctggt   1260

ttgtctcagg gaccaccaag agagatgatg ccaaatatat gtattacctc aaaaagttca   1320

tcatggaaac cttaaaagcc atcaagctgg atggggtgga tgtcatcggg tataccgcat   1380

ggtccctcat ggatggtttc gagtggcaca gaggttacag catcaggcgt ggactcttct   1440

atgttgactt tctaagccag gacaagatgt tgttgccaaa gtcttcagcc ttgttctacc   1500

aaaagctgat agagaaaaat ggcttccctc ctttacctga aaatcagccc ctagaaggga   1560

catttccctg tgactttgct tggggagttg ttgacaacta cattcaagta gataccactc   1620

tgtctcagtt taccgacctg aatgtttacc tgtgggatgt ccaccacagt aaaaggctta   1680

ttaaagtgga tggggttgtg accaagaaga ggaaatccta ctgtgttgac tttgctgcca   1740

tccagcccca gatcgcttta ctccaggaaa tgcacgttac acattttcgc ttctccctgg   1800

actgggccct gattctccct ctgggtaacc agtcccaggt gaaccacacc atcctgcagt   1860

actatcgctg catggccagc gagcttgtcc gtgtcaacat caccccagtg gtggccctgt   1920

ggcagcctat ggccccgaac caaggactgc cgcgcctcct ggccaggcag ggcgcctggg   1980

agaaccccta cactgccctg gcctttgcag agtatgcccg actgtgcttt caagagctcg   2040

gccatcacgt caagctttgg ataacgatga atgagccgta tacaaggaat atgacataca   2100

gtgctggcca caaccttctg aaggcccatg ccctggcttg gcatgtgtac aatgaaaagt   2160

ttaggcatgc tcagaatggg aaaatatcca tagccttgca ggctgattgg atagaacctg   2220

cctgcccttt ctcccaaaag gacaaagagg tggccgagag agttttggaa tttgacattg   2280

gctggctggc tgagcccatt ttcggctctg gagattatcc atgggtgatg agggactggc   2340

tgaaccaaag aaacaatttt cttcttcctt atttcactga agatgaaaaa aagctaatcc   2400

agggtacctt tgactttttg gctttaagcc attataccac catccttgta gactcagaaa   2460

aagaagatcc aataaaatac aatgattacc tagaagtgca agaaatgacc gacatcacgt   2520

ggctcaactc ccccagtcag gtggcggtag tgccctgggg gttgcgcaaa gtgctgaact   2580

ggctgaagtt caagtacgga gacctcccca tgtacataat atccaacgga atcgatgacg   2640

ggctgcatgc tgaggacgac cagctgaggg tgtattatat gcagaattac ataaacgaag   2700

ctctcaaagc ccacatactg gatggtatca atctttgcgg atactttgct tattcgttta   2760

acgaccgcac agctccgagg tttggcctct atcgttatgc tgcagatcag tttgagccca   2820

aggcatccat gaaacattac aggaaaatta ttgacagcaa tggtttcccg ggcccagaaa   2880

ctctggaaag attttgtcca gaagaattca ccgtgtgtac tgagtgcagt ttttttcaca   2940

cccgaaagtc tttactggct ttcatagctt ttctattttt tgcttctatt atttctctct   3000

cccttatatt ttactactcg aagaaaggca gaagaagtta caaatagttc tgaacatttt   3060

tctattcatt cattttgaaa taattatgca gacacatcag ctgttaacca tttgcacctc   3120

taagtgttgt gaaactgtaa atttcataca tttgacttct agaaaacatt tttgtggctt   3180

atgacagagg ttttgaaatg ggcataggtg atcgtaaaat attgaataat gcgaatagtg   3240

cctgaatttg ttctcttttt gggtgattaa aaaactgaca ggcactataa tttctgtaac   3300

acactaacaa aagcatgaaa aataggaacc acaccaatgc aacatttgtg cagaaatttg   3360

aatgacaaga ttaggaatat tttcttctgc acccacttct aaatttaatg tttttctgga   3420

agtagtaatt gcaagagttc gaatagaaag ttatgtacca agtaaccatt tctcagctgc   3480

cataataatg cctagtggct tcccctctgt caaatctagt ttcctatgga aaagaagatg   3540

gcagatacag gagagacgac agagggtcct aggctggaat gttcctttcg aaagcaatgc   3600

ttctatcaaa tactagtatt aatttatgta tctggttaat gacatacttg gagagcaaat   3660

tatggaaatg tgtattttat atgatttttg aggtcctgtc taaaccctgt gtccctgagg   3720

gatctgtctc actggcatct tgttgagggc cttgcacata ggaaactttt gataagtatc   3780

tgcggaaaaa caaacatgaa tcctgtgata ttgggctctt caggaagcat aaagcaattg   3840

tgaaatacag tataccgcag tggctctagg tggaggaaag gaggaaaaag tgcttattat   3900

gtgcaacatt atgattaatc tgattataca ccatttttga gcagatcttg gaatgaatga   3960

catgaccttt ccctagagaa taaggatgaa ataatcactc attctatgaa cagtgacact   4020

actttctatt ctttagctgt actgtaattt ctttgagttg atagttttac aaattcttaa   4080

taggttcaaa agcaatctgg tctgaataac actggatttg tttctgtgat ctctgaggtc   4140

tattttatgt ttttgctgct acttctgtgg aagtagcttt gaactagttt tactttgaac   4200

tttcacgctg aaacatgcta gtgatatcta gaaagggcta attaggtctc atcctttaat   4260

gccccttaaa taagtcttgc tgattttcag acagggaagt ctctctatta cactggagct   4320

gttttataga taagtcaata ttgtatcagg caagataaac caatgtcata acaggcattg   4380

ccaacctcac tgacacaggg tcatagtgta taataatata ctgtactata taatatatca   4440

tctttagagg tatgattttt tcatgaaaga taagcttttg gtaatattca ttttaaagtg   4500

gacttattaa aattggatgc tagagaatca agtttatttt atgtatatat ttttctgatt   4560

ataagagtaa tatatgttca ttgtaaaaat ttttaaaaca cagaaactat atgcaaagaa   4620

aaaataaaaa ttatctataa tctcagaacc cagaaatagc cactattaac atttcctacg   4680

tattttattt tacatagatc atattgtata tagttagtat ctttattaat ttttattatg   4740

aaactttcct ttgtcattat tagtcttcaa aagcatgatt tttaatagtt gttgagtatt   4800

ccaccacagg aatgtatcac aacttaaccg ttcccgtttg ttagactagt ttcttattaa   4860

tgttgatgaa tgttgtttaa aaataatttt gttgctacat ttactttaat ttccttgact   4920

gtaaagagaa gtaattttgc tccttgataa agtattatat taataataaa tctgcctgca   4980

actttttgcc ttctttcata atc                                           5003


<210>  2
<211>  1012
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  3
<211>  3279
<212>  DNA
<213>  Homo Sapiens

<400>  3
atcctcagtc tcccagttca agctaatcat tgacagagct ttacaatcac aagcttttac     60

tgaagctttg ataagacagt ccagcagttg gtggcaaatg aagccaggct gtgcggcagg    120

atctccaggg aatgaatgga ttttcttcag cactgatgaa ataaccacac gctataggaa    180

tacaatgtcc aacgggggat tgcaaagatc tgtcatcctg tcagcactta ttctgctacg    240

agctgttact ggattctctg gagatggaag agctatatgg tctaaaaatc ctaattttac    300

tccggtaaat gaaagtcagc tgtttctcta tgacactttc cctaaaaact ttttctgggg    360

tattgggact ggagcattgc aagtggaagg gagttggaag aaggatggaa aaggaccttc    420

tatatgggat catttcatcc acacacacct taaaaatgtc agcagcacga atggttccag    480

tgacagttat atttttctgg aaaaagactt atcagccctg gattttatag gagtttcttt    540

ttatcaattt tcaatttcct ggccaaggct tttccccgat ggaatagtaa cagttgccaa    600

cgcaaaaggt ctgcagtact acagtactct tctggacgct ctagtgctta gaaacattga    660

acctatagtt actttatacc actgggattt gcctttggca ctacaagaaa aatatggggg    720

gtggaaaaat gataccataa tagatatctt caatgactat gccacatact gtttccagat    780

gtttggggac cgtgtcaaat attggattac aattcacaac ccatatctag tggcttggca    840

tgggtatggg acaggtatgc atgcccctgg agagaaggga aatttagcag ctgtctacac    900

tgtgggacac aacttgatca aggctcactc gaaagtttgg cataactaca acacacattt    960

ccgcccacat cagaagggtt ggttatcgat cacgttggga tctcattgga tcgagccaaa   1020

ccggtcggaa aacacgatgg atatattcaa atgtcaacaa tccatggttt ctgtgcttgg   1080

atggtttgcc aaccctatcc atggggatgg cgactatcca gaggggatga gaaagaagtt   1140

gttctccgtt ctacccattt tctctgaagc agagaagcat gagatgagag gcacagctga   1200

tttctttgcc ttttcttttg gacccaacaa cttcaagccc ctaaacacca tggctaaaat   1260

gggacaaaat gtttcactta atttaagaga agcgctgaac tggattaaac tggaatacaa   1320

caaccctcga atcttgattg ctgagaatgg ctggttcaca gacagtcgtg tgaaaacaga   1380

agacaccacg gccatctaca tgatgaagaa tttcctcagc caggtgcttc aagcaataag   1440

gttagatgaa atacgagtgt ttggttatac tgcctggtct ctcctggatg gctttgaatg   1500

gcaggatgct tacaccatcc gccgaggatt attttatgtg gattttaaca gtaaacagaa   1560

agagcggaaa cctaagtctt cagcacacta ctacaaacag atcatacgag aaaatggttt   1620

ttctttaaaa gagtccacgc cagatgtgca gggccagttt ccctgtgact tctcctgggg   1680

tgtcactgaa tctgttctta agcccgagtc tgtggcttcg tccccacagt tcagcgatcc   1740

tcatctgtac gtgtggaacg ccactggcaa cagactgttg caccgagtgg aaggggtgag   1800

gctgaaaaca cgacccgctc aatgcacaga ttttgtaaac atcaaaaaac aacttgagat   1860

gttggcaaga atgaaagtca cccactaccg gtttgctctg gattgggcct cggtccttcc   1920

cactggcaac ctgtccgcgg tgaaccgaca ggccctgagg tactacaggt gcgtggtcag   1980

tgaggggctg aagcttggca tctccgcgat ggtcaccctg tattatccga cccacgccca   2040

cctaggcctc cccgagcctc tgttgcatgc cgacgggtgg ctgaacccat cgacggccga   2100

ggccttccag gcctacgctg ggctgtgctt ccaggagctg ggggacctgg tgaagctctg   2160

gatcaccatc aacgagccta accggctaag tgacatctac aaccgctctg gcaacgacac   2220

ctacggggcg gcgcacaacc tgctggtggc ccacgccctg gcctggcgcc tctacgaccg   2280

gcagttcagg ccctcacagc gcggggccgt gtcgctgtcg ctgcacgcgg actgggcgga   2340

acccgccaac ccctatgctg actcgcactg gagggcggcc gagcgcttcc tgcagttcga   2400

gatcgcctgg ttcgccgagc cgctcttcaa gaccggggac taccccgcgg ccatgaggga   2460

atacattgcc tccaagcacc gacgggggct ttccagctcg gccctgccgc gcctcaccga   2520

ggccgaaagg aggctgctca agggcacggt cgacttctgc gcgctcaacc acttcaccac   2580

taggttcgtg atgcacgagc agctggccgg cagccgctac gactcggaca gggacatcca   2640

gtttctgcag gacatcaccc gcctgagctc ccccacgcgc ctggctgtga ttccctgggg   2700

ggtgcgcaag ctgctgcggt gggtccggag gaactacggc gacatggaca tttacatcac   2760

cgccagtggc atcgacgacc aggctctgga ggatgaccgg ctccggaagt actacctagg   2820

gaagtacctt caggaggtgc tgaaagcata cctgattgat aaagtcagaa tcaaaggcta   2880

ttatgcattc aaactggctg aagagaaatc taaacccaga tttggattct tcacatctga   2940

ttttaaagct aaatcctcaa tacaatttta caacaaagtg atcagcagca ggggcttccc   3000

ttttgagaac agtagttcta gatgcagtca gacccaagaa aatacagagt gcactgtctg   3060

cttattcctt gtgcagaaga aaccactgat attcctgggt tgttgcttct tctccaccct   3120

ggttctactc ttatcaattg ccatttttca aaggcagaag agaagaaagt tttggaaagc   3180

aaaaaactta caacacatac cattaaagaa aggcaagaga gttgttagct aaactgatct   3240

gtctgcatga tagacagttt aaaaattcat cccagttcc                          3279


<210>  4
<211>  1044
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210>  5
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  5

Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala 
1               5                   10                  15      


Tyr Gln Thr Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg 
        35                  40                  45              


Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr 
    50                  55                  60                  


Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu 
65                  70                  75                  80  


Ala Leu Arg Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp 
                85                  90                  95      


Ala Arg Val Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly 
            100                 105                 110         


Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val 
        115                 120                 125             


Gln Pro Val Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln 
    130                 135                 140                 


Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg 
145                 150                 155                 160 


Asp Tyr Ala Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr 
                165                 170                 175     


Trp Ile Thr Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala 
            180                 185                 190         


Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr 
        195                 200                 205             


Leu Val Ala His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu 
    210                 215                 220                 


Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala 
225                 230                 235                 240 


Leu Ser Ser His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile 
                245                 250                 255     


Lys Glu Cys Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys 
            260                 265                 270         


Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu 
        275                 280                 285             


Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys 
    290                 295                 300                 


Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe 
305                 310                 315                 320 


Gln Leu Leu Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn 
                325                 330                 335     


Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln 
            340                 345                 350         


Ile Phe Ile Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg 
        355                 360                 365             


Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr 
    370                 375                 380                 


Leu Lys Ala Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala 
385                 390                 395                 400 


Trp Ser Leu Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg 
                405                 410                 415     


Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu 
            420                 425                 430         


Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly 
        435                 440                 445             


Phe 
    


<210>  6
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  6

Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile 
1               5                   10                  15      


Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr Leu 
            20                  25                  30          


Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val Val 
        35                  40                  45              


Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro 
    50                  55                  60                  


Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe Ser 
65                  70                  75                  80  


Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn 
                85                  90                  95      


His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg 
            100                 105                 110         


Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn 
        115                 120                 125             


Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro 
    130                 135                 140                 


Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu 
145                 150                 155                 160 


Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr 
                165                 170                 175     


Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His Ala 
            180                 185                 190         


Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly 
        195                 200                 205             


Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro 
    210                 215                 220                 


Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp 
225                 230                 235                 240 


Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp 
                245                 250                 255     


Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr 
            260                 265                 270         


Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu 
        275                 280                 285             


Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp 
    290                 295                 300                 


Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile 
305                 310                 315                 320 


Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu 
                325                 330                 335     


Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met 
            340                 345                 350         


Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp Asp 
        355                 360                 365             


Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys 
    370                 375                 380                 


Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser 
385                 390                 395                 400 


Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala 
                405                 410                 415     


Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile Ile 
            420                 425                 430         


Asp Ser Asn Gly Phe 
        435         


<210>  7
<211>  949
<212>  PRT
<213>  Homo Sapiens

<400>  7

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Leu 
945                 


<210>  8
<211>  33
<212>  PRT
<213>  Homo Sapiens

<400>  8

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala 
    


<210>  9
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Thr Arg Cys Arg Arg Leu Arg Ala 
            20                  25  


<210>  10
<211>  45
<212>  DNA
<213>  Homo Sapiens

<400>  10
ggaggtggag gttcaggagg tggaggttca ggaggtggag gttca                     45


<210>  11
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  12
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  12

Gly Gly Gly Gly Ser 
1               5   


<210>  13
<211>  1
<212>  PRT
<213>  Homo Sapiens

<400>  13

Gly 
1   


<210>  14
<211>  2
<212>  PRT
<213>  Homo Sapiens

<400>  14

Gly Gly 
1       


<210>  15
<211>  2
<212>  PRT
<213>  Homo Sapiens

<400>  15

Gly Ser 
1       


<210>  16
<211>  3
<212>  PRT
<213>  Homo Sapiens

<400>  16

Gly Gly Ser 
1           


<210>  17
<211>  1
<212>  PRT
<213>  Homo Sapiens

<400>  17

Ala 
1   


<210>  18
<211>  2
<212>  PRT
<213>  Homo Sapiens

<400>  18

Ala Ala 
1       


<210>  19
<211>  1228
<212>  PRT
<213>  Homo Sapiens

<400>  19

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            980                 985                 990         


Gly Ser Gly Gly Gly Gly Ser Leu  Lys Tyr Pro Asn Ala  Ser Pro Leu 
        995                 1000                 1005             


Leu Gly  Ser Ser Trp Gly Gly  Leu Ile His Leu Tyr  Thr Ala Thr 
    1010                 1015                 1020             


Ala Arg  Asn Ser Tyr His Leu  Gln Ile His Lys Asn  Gly His Val 
    1025                 1030                 1035             


Asp Gly  Ala Pro His Gln Thr  Ile Tyr Ser Ala Leu  Met Ile Arg 
    1040                 1045                 1050             


Ser Glu  Asp Ala Gly Phe Val  Val Ile Thr Gly Val  Met Ser Arg 
    1055                 1060                 1065             


Arg Tyr  Leu Cys Met Asp Phe  Arg Gly Asn Ile Phe  Gly Ser His 
    1070                 1075                 1080             


Tyr Phe  Asp Pro Glu Asn Cys  Arg Phe Gln His Gln  Thr Leu Glu 
    1085                 1090                 1095             


Asn Gly  Tyr Asp Val Tyr His  Ser Pro Gln Tyr His  Phe Leu Val 
    1100                 1105                 1110             


Ser Leu  Gly Arg Ala Lys Arg  Ala Phe Leu Pro Gly  Met Asn Pro 
    1115                 1120                 1125             


Pro Pro  Tyr Ser Gln Phe Leu  Ser Arg Arg Asn Glu  Ile Pro Leu 
    1130                 1135                 1140             


Ile His  Phe Asn Thr Pro Ile  Pro Arg Arg His Thr  Gln Ser Ala 
    1145                 1150                 1155             


Glu Asp  Asp Ser Glu Arg Asp  Pro Leu Asn Val Leu  Lys Pro Arg 
    1160                 1165                 1170             


Ala Arg  Met Thr Pro Ala Pro  Ala Ser Cys Ser Gln  Glu Leu Pro 
    1175                 1180                 1185             


Ser Ala  Glu Asp Asn Ser Pro  Met Ala Ser Asp Pro  Leu Gly Val 
    1190                 1195                 1200             


Val Arg  Gly Gly Arg Val Asn  Thr His Ala Gly Gly  Thr Gly Pro 
    1205                 1210                 1215             


Glu Gly  Cys Arg Pro Phe Ala  Lys Phe Ile 
    1220                 1225             


<210>  20
<211>  1220
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Leu Gly Gly Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln 
            20                  25                  30          


Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu 
        35                  40                  45              


Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala 
    50                  55                  60                  


Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser 
65                  70                  75                  80  


Ile Trp Asp Thr Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser 
                85                  90                  95      


Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala 
            100                 105                 110         


Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr 
        115                 120                 125             


Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser 
    130                 135                 140                 


Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu 
145                 150                 155                 160 


Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly 
                165                 170                 175     


Val Gln Pro Val Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu 
            180                 185                 190         


Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe 
        195                 200                 205             


Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys 
    210                 215                 220                 


Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr 
225                 230                 235                 240 


Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly 
                245                 250                 255     


Tyr Leu Val Ala His Asn Leu Leu Leu Ala His Ala Lys Val Trp His 
            260                 265                 270         


Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile 
        275                 280                 285             


Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser 
    290                 295                 300                 


Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala 
305                 310                 315                 320 


Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn 
                325                 330                 335     


Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile 
            340                 345                 350         


Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser 
        355                 360                 365             


Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro 
    370                 375                 380                 


Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro 
385                 390                 395                 400 


Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys 
                405                 410                 415     


Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu 
            420                 425                 430         


Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr 
        435                 440                 445             


Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile 
    450                 455                 460                 


Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu 
465                 470                 475                 480 


Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn 
                485                 490                 495     


Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro 
            500                 505                 510         


Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr 
        515                 520                 525             


Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His 
    530                 535                 540                 


His Ser Lys Arg Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg 
545                 550                 555                 560 


Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu 
                565                 570                 575     


Leu Gln Glu Met His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala 
            580                 585                 590         


Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu 
        595                 600                 605             


Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr 
    610                 615                 620                 


Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro 
625                 630                 635                 640 


Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu 
                645                 650                 655     


Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His 
            660                 665                 670         


Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr 
        675                 680                 685             


Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His 
    690                 695                 700                 


Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile 
705                 710                 715                 720 


Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys 
                725                 730                 735     


Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu 
            740                 745                 750         


Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp 
        755                 760                 765             


Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp 
    770                 775                 780                 


Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His 
785                 790                 795                 800 


Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr 
                805                 810                 815     


Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn 
            820                 825                 830         


Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu 
        835                 840                 845             


Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser 
    850                 855                 860                 


Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val 
865                 870                 875                 880 


Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu 
                885                 890                 895     


Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg 
            900                 905                 910         


Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu 
        915                 920                 925             


Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly 
    930                 935                 940                 


Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr 
945                 950                 955                 960 


Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg Lys Ser Leu Gly Ser 
                965                 970                 975     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
            980                 985                 990         


Lys Tyr Pro Asn Ala Ser Pro Leu  Leu Gly Ser Ser Trp  Gly Gly Leu 
        995                 1000                 1005             


Ile His  Leu Tyr Thr Ala Thr  Ala Arg Asn Ser Tyr  His Leu Gln 
    1010                 1015                 1020             


Ile His  Lys Asn Gly His Val  Asp Gly Ala Pro His  Gln Thr Ile 
    1025                 1030                 1035             


Tyr Ser  Ala Leu Met Ile Arg  Ser Glu Asp Ala Gly  Phe Val Val 
    1040                 1045                 1050             


Ile Thr  Gly Val Met Ser Arg  Arg Tyr Leu Cys Met  Asp Phe Arg 
    1055                 1060                 1065             


Gly Asn  Ile Phe Gly Ser His  Tyr Phe Asp Pro Glu  Asn Cys Arg 
    1070                 1075                 1080             


Phe Gln  His Gln Thr Leu Glu  Asn Gly Tyr Asp Val  Tyr His Ser 
    1085                 1090                 1095             


Pro Gln  Tyr His Phe Leu Val  Ser Leu Gly Arg Ala  Lys Arg Ala 
    1100                 1105                 1110             


Phe Leu  Pro Gly Met Asn Pro  Pro Pro Tyr Ser Gln  Phe Leu Ser 
    1115                 1120                 1125             


Arg Arg  Asn Glu Ile Pro Leu  Ile His Phe Asn Thr  Pro Ile Pro 
    1130                 1135                 1140             


Arg Arg  His Thr Gln Ser Ala  Glu Asp Asp Ser Glu  Arg Asp Pro 
    1145                 1150                 1155             


Leu Asn  Val Leu Lys Pro Arg  Ala Arg Met Thr Pro  Ala Pro Ala 
    1160                 1165                 1170             


Ser Cys  Ser Gln Glu Leu Pro  Ser Ala Glu Asp Asn  Ser Pro Met 
    1175                 1180                 1185             


Ala Ser  Asp Pro Leu Gly Val  Val Arg Gly Gly Arg  Val Asn Thr 
    1190                 1195                 1200             


His Ala  Gly Gly Thr Gly Pro  Glu Gly Cys Arg Pro  Phe Ala Lys 
    1205                 1210                 1215             


Phe Ile  
    1220 


<210>  21
<211>  762
<212>  PRT
<213>  Homo Sapiens

<400>  21

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Leu Lys Tyr Pro Asn Ala Ser Pro Leu Leu Gly 
    530                 535                 540                 


Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg Asn 
545                 550                 555                 560 


Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala Pro 
                565                 570                 575     


His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala Gly 
            580                 585                 590         


Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met Asp 
        595                 600                 605             


Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn Cys 
    610                 615                 620                 


Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His Ser 
625                 630                 635                 640 


Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala Phe 
                645                 650                 655     


Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg Arg 
            660                 665                 670         


Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg His 
        675                 680                 685             


Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu 
    690                 695                 700                 


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu 
705                 710                 715                 720 


Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly 
                725                 730                 735     


Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro 
            740                 745                 750         


Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
        755                 760         


<210>  22
<211>  752
<212>  PRT
<213>  Homo Sapiens

<400>  22

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Pro 
            20                  25                  30          


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
        35                  40                  45              


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
    50                  55                  60                  


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
65                  70                  75                  80  


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
                85                  90                  95      


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
            100                 105                 110         


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
        115                 120                 125             


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
    130                 135                 140                 


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
145                 150                 155                 160 


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
                165                 170                 175     


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
            180                 185                 190         


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
        195                 200                 205             


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
    210                 215                 220                 


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
225                 230                 235                 240 


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
                245                 250                 255     


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
            260                 265                 270         


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
        275                 280                 285             


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
    290                 295                 300                 


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
305                 310                 315                 320 


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
                325                 330                 335     


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
            340                 345                 350         


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
        355                 360                 365             


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
    370                 375                 380                 


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
385                 390                 395                 400 


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
                405                 410                 415     


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
            420                 425                 430         


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
        435                 440                 445             


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
    450                 455                 460                 


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
465                 470                 475                 480 


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
                485                 490                 495     


Cys Ser Phe Phe His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Lys Tyr Pro Asn 
        515                 520                 525             


Ala Ser Pro Leu Leu Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr 
    530                 535                 540                 


Thr Ala Thr Ala Arg Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly 
545                 550                 555                 560 


His Val Asp Gly Ala Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile 
                565                 570                 575     


Arg Ser Glu Asp Ala Gly Phe Val Val Ile Thr Gly Val Met Ser Arg 
            580                 585                 590         


Arg Tyr Leu Cys Met Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr 
        595                 600                 605             


Phe Asp Pro Glu Asn Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly 
    610                 615                 620                 


Tyr Asp Val Tyr His Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly 
625                 630                 635                 640 


Arg Ala Lys Arg Ala Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser 
                645                 650                 655     


Gln Phe Leu Ser Arg Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr 
            660                 665                 670         


Pro Ile Pro Arg Arg His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg 
        675                 680                 685             


Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro 
    690                 695                 700                 


Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met 
705                 710                 715                 720 


Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val Asn Thr His 
                725                 730                 735     


Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
            740                 745                 750         


<210>  23
<211>  1215
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Ser Gly Thr Phe Pro Asp Gly Phe Leu Trp Ala 
        515                 520                 525             


Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His Gly 
    530                 535                 540                 


Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala Pro 
545                 550                 555                 560 


Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser Pro 
                565                 570                 575     


Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn Val 
            580                 585                 590         


Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr Arg 
        595                 600                 605             


Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly Val 
    610                 615                 620                 


Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg Leu 
625                 630                 635                 640 


Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp Leu 
                645                 650                 655     


Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala Leu 
            660                 665                 670         


Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe Gly 
        675                 680                 685             


Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val Ala 
    690                 695                 700                 


Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly Ser 
705                 710                 715                 720 


Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His Ala 
                725                 730                 735     


Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly Gly 
            740                 745                 750         


Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg Met 
        755                 760                 765             


Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val Leu 
    770                 775                 780                 


Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu Ser 
785                 790                 795                 800 


Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser Glu 
                805                 810                 815     


Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe Gly 
            820                 825                 830         


Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg Gln 
        835                 840                 845             


Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu Glu 
    850                 855                 860                 


Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val Ser 
865                 870                 875                 880 


Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys Lys 
                885                 890                 895     


Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp Val 
            900                 905                 910         


Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His Arg 
        915                 920                 925             


Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser Gln 
    930                 935                 940                 


Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys Leu 
945                 950                 955                 960 


Ile Glu Lys Asn Gly Phe Pro Glu Phe Gly Ser Gly Gly Gly Gly Ser 
                965                 970                 975     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Lys Tyr Pro Asn Ala 
            980                 985                 990         


Ser Pro Leu Leu Gly Ser Ser Trp  Gly Gly Leu Ile His  Leu Tyr Thr 
        995                 1000                 1005             


Ala Thr  Ala Arg Asn Ser Tyr  His Leu Gln Ile His  Lys Asn Gly 
    1010                 1015                 1020             


His Val  Asp Gly Ala Pro His  Gln Thr Ile Tyr Ser  Ala Leu Met 
    1025                 1030                 1035             


Ile Arg  Ser Glu Asp Ala Gly  Phe Val Val Ile Thr  Gly Val Met 
    1040                 1045                 1050             


Ser Arg  Arg Tyr Leu Cys Met  Asp Phe Arg Gly Asn  Ile Phe Gly 
    1055                 1060                 1065             


Ser His  Tyr Phe Asp Pro Glu  Asn Cys Arg Phe Gln  His Gln Thr 
    1070                 1075                 1080             


Leu Glu  Asn Gly Tyr Asp Val  Tyr His Ser Pro Gln  Tyr His Phe 
    1085                 1090                 1095             


Leu Val  Ser Leu Gly Arg Ala  Lys Arg Ala Phe Leu  Pro Gly Met 
    1100                 1105                 1110             


Asn Pro  Pro Pro Tyr Ser Gln  Phe Leu Ser Arg Arg  Asn Glu Ile 
    1115                 1120                 1125             


Pro Leu  Ile His Phe Asn Thr  Pro Ile Pro Arg Arg  His Thr Gln 
    1130                 1135                 1140             


Ser Ala  Glu Asp Asp Ser Glu  Arg Asp Pro Leu Asn  Val Leu Lys 
    1145                 1150                 1155             


Pro Arg  Ala Arg Met Thr Pro  Ala Pro Ala Ser Cys  Ser Gln Glu 
    1160                 1165                 1170             


Leu Pro  Ser Ala Glu Asp Asn  Ser Pro Met Ala Ser  Asp Pro Leu 
    1175                 1180                 1185             


Gly Val  Val Arg Gly Gly Arg  Val Asn Thr His Ala  Gly Gly Thr 
    1190                 1195                 1200             


Gly Pro  Glu Gly Cys Arg Pro  Phe Ala Lys Phe Ile  
    1205                 1210                 1215 


<210>  24
<211>  1189
<212>  PRT
<213>  Homo Sapiens

<400>  24

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Pro 
            20                  25                  30          


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
        35                  40                  45              


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
    50                  55                  60                  


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
65                  70                  75                  80  


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
                85                  90                  95      


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
            100                 105                 110         


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
        115                 120                 125             


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
    130                 135                 140                 


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
145                 150                 155                 160 


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
                165                 170                 175     


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
            180                 185                 190         


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
        195                 200                 205             


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
    210                 215                 220                 


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
225                 230                 235                 240 


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
                245                 250                 255     


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
            260                 265                 270         


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
        275                 280                 285             


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
    290                 295                 300                 


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
305                 310                 315                 320 


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
                325                 330                 335     


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
            340                 345                 350         


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
        355                 360                 365             


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
    370                 375                 380                 


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
385                 390                 395                 400 


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
                405                 410                 415     


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
            420                 425                 430         


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
        435                 440                 445             


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
    450                 455                 460                 


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
465                 470                 475                 480 


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
                485                 490                 495     


Cys Ser Phe Phe His Thr Arg Lys Ser Leu Gly Thr Phe Pro Cys Asp 
            500                 505                 510         


Phe Ala Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu 
        515                 520                 525             


Ser Gln Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser 
    530                 535                 540                 


Lys Arg Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser 
545                 550                 555                 560 


Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln 
                565                 570                 575     


Glu Met His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile 
            580                 585                 590         


Leu Pro Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr 
        595                 600                 605             


Tyr Arg Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val 
    610                 615                 620                 


Val Ala Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu 
625                 630                 635                 640 


Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe 
                645                 650                 655     


Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys 
            660                 665                 670         


Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser 
        675                 680                 685             


Ala Gly His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr 
    690                 695                 700                 


Asn Glu Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu 
705                 710                 715                 720 


Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys 
                725                 730                 735     


Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu 
            740                 745                 750         


Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu 
        755                 760                 765             


Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys 
    770                 775                 780                 


Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr 
785                 790                 795                 800 


Thr Ile Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp 
                805                 810                 815     


Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro 
            820                 825                 830         


Ser Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp 
        835                 840                 845             


Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly 
    850                 855                 860                 


Ile Asp Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr 
865                 870                 875                 880 


Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly 
                885                 890                 895     


Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala 
            900                 905                 910         


Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys 
        915                 920                 925             


Ala Ser Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Gly 
    930                 935                 940                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
945                 950                 955                 960 


Leu Lys Tyr Pro Asn Ala Ser Pro Leu Leu Gly Ser Ser Trp Gly Gly 
                965                 970                 975     


Leu Ile His Leu Tyr Thr Ala Thr Ala Arg Asn Ser Tyr His Leu Gln 
            980                 985                 990         


Ile His Lys Asn Gly His Val Asp  Gly Ala Pro His Gln  Thr Ile Tyr 
        995                 1000                 1005             


Ser Ala  Leu Met Ile Arg Ser  Glu Asp Ala Gly Phe  Val Val Ile 
    1010                 1015                 1020             


Thr Gly  Val Met Ser Arg Arg  Tyr Leu Cys Met Asp  Phe Arg Gly 
    1025                 1030                 1035             


Asn Ile  Phe Gly Ser His Tyr  Phe Asp Pro Glu Asn  Cys Arg Phe 
    1040                 1045                 1050             


Gln His  Gln Thr Leu Glu Asn  Gly Tyr Asp Val Tyr  His Ser Pro 
    1055                 1060                 1065             


Gln Tyr  His Phe Leu Val Ser  Leu Gly Arg Ala Lys  Arg Ala Phe 
    1070                 1075                 1080             


Leu Pro  Gly Met Asn Pro Pro  Pro Tyr Ser Gln Phe  Leu Ser Arg 
    1085                 1090                 1095             


Arg Asn  Glu Ile Pro Leu Ile  His Phe Asn Thr Pro  Ile Pro Arg 
    1100                 1105                 1110             


Arg His  Thr Gln Ser Ala Glu  Asp Asp Ser Glu Arg  Asp Pro Leu 
    1115                 1120                 1125             


Asn Val  Leu Lys Pro Arg Ala  Arg Met Thr Pro Ala  Pro Ala Ser 
    1130                 1135                 1140             


Cys Ser  Gln Glu Leu Pro Ser  Ala Glu Asp Asn Ser  Pro Met Ala 
    1145                 1150                 1155             


Ser Asp  Pro Leu Gly Val Val  Arg Gly Gly Arg Val  Asn Thr His 
    1160                 1165                 1170             


Ala Gly  Gly Thr Gly Pro Glu  Gly Cys Arg Pro Phe  Ala Lys Phe 
    1175                 1180                 1185             


Ile 
    


<210>  25
<211>  1219
<212>  PRT
<213>  Homo Sapiens

<400>  25

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Lys Glu Pro 
            260                 265                 270         


Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
        275                 280                 285             


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
    290                 295                 300                 


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
305                 310                 315                 320 


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
                325                 330                 335     


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
            340                 345                 350         


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
        355                 360                 365             


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
    370                 375                 380                 


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
385                 390                 395                 400 


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
                405                 410                 415     


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
            420                 425                 430         


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
        435                 440                 445             


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
    450                 455                 460                 


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
465                 470                 475                 480 


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
                485                 490                 495     


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
            500                 505                 510         


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
        515                 520                 525             


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
    530                 535                 540                 


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
545                 550                 555                 560 


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
                565                 570                 575     


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
            580                 585                 590         


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
        595                 600                 605             


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
    610                 615                 620                 


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
625                 630                 635                 640 


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
                645                 650                 655     


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
            660                 665                 670         


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
        675                 680                 685             


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
    690                 695                 700                 


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
705                 710                 715                 720 


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
                725                 730                 735     


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
            740                 745                 750         


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
        755                 760                 765             


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
    770                 775                 780                 


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
785                 790                 795                 800 


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
                805                 810                 815     


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
            820                 825                 830         


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
        835                 840                 845             


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
    850                 855                 860                 


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
865                 870                 875                 880 


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
                885                 890                 895     


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
            900                 905                 910         


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
        915                 920                 925             


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
    930                 935                 940                 


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
945                 950                 955                 960 


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
                965                 970                 975     


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
            980                 985                 990         


Asp Ile Gly Trp Leu Ala Glu Pro  Ile Phe Gly Ser Gly  Asp Tyr Pro 
        995                 1000                 1005             


Trp Val  Met Arg Asp Trp Leu  Asn Gln Arg Asn Asn  Phe Leu Leu 
    1010                 1015                 1020             


Pro Tyr  Phe Thr Glu Asp Glu  Lys Lys Leu Ile Gln  Gly Thr Phe 
    1025                 1030                 1035             


Asp Phe  Leu Ala Leu Ser His  Tyr Thr Thr Ile Leu  Val Asp Ser 
    1040                 1045                 1050             


Glu Lys  Glu Asp Pro Ile Lys  Tyr Asn Asp Tyr Leu  Glu Val Gln 
    1055                 1060                 1065             


Glu Met  Thr Asp Ile Thr Trp  Leu Asn Ser Pro Ser  Gln Val Ala 
    1070                 1075                 1080             


Val Val  Pro Trp Gly Leu Arg  Lys Val Leu Asn Trp  Leu Lys Phe 
    1085                 1090                 1095             


Lys Tyr  Gly Asp Leu Pro Met  Tyr Ile Ile Ser Asn  Gly Ile Asp 
    1100                 1105                 1110             


Asp Gly  Leu His Ala Glu Asp  Asp Gln Leu Arg Val  Tyr Tyr Met 
    1115                 1120                 1125             


Gln Asn  Tyr Ile Asn Glu Ala  Leu Lys Ala His Ile  Leu Asp Gly 
    1130                 1135                 1140             


Ile Asn  Leu Cys Gly Tyr Phe  Ala Tyr Ser Phe Asn  Asp Arg Thr 
    1145                 1150                 1155             


Ala Pro  Arg Phe Gly Leu Tyr  Arg Tyr Ala Ala Asp  Gln Phe Glu 
    1160                 1165                 1170             


Pro Lys  Ala Ser Met Lys His  Tyr Arg Lys Ile Ile  Asp Ser Asn 
    1175                 1180                 1185             


Gly Phe  Pro Gly Pro Glu Thr  Leu Glu Arg Phe Cys  Pro Glu Glu 
    1190                 1195                 1200             


Phe Thr  Val Cys Thr Glu Cys  Ser Phe Phe His Thr  Arg Lys Ser 
    1205                 1210                 1215             


Leu 
    


<210>  26
<211>  700
<212>  PRT
<213>  Homo Sapiens

<400>  26

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gln Gly Thr Phe Pro 
                245                 250                 255     


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
            260                 265                 270         


Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
        275                 280                 285             


His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro 
    290                 295                 300                 


Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser 
305                 310                 315                 320 


Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu 
                325                 330                 335     


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
            340                 345                 350         


Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
        355                 360                 365             


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
    370                 375                 380                 


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly 
385                 390                 395                 400 


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
                405                 410                 415     


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
            420                 425                 430         


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
        435                 440                 445             


Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn 
    450                 455                 460                 


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
465                 470                 475                 480 


Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp 
                485                 490                 495     


Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys 
            500                 505                 510         


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp 
        515                 520                 525             


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro 
    530                 535                 540                 


Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe 
545                 550                 555                 560 


Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
                565                 570                 575     


His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
            580                 585                 590         


Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu 
        595                 600                 605             


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
    610                 615                 620                 


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys 
625                 630                 635                 640 


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
                645                 650                 655     


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
            660                 665                 670         


Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala 
        675                 680                 685             


Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe 
    690                 695                 700 


<210>  27
<211>  688
<212>  PRT
<213>  Homo Sapiens

<400>  27

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Thr Phe Pro Cys 
                245                 250                 255     


Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr 
            260                 265                 270         


Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His 
        275                 280                 285             


Ser Lys Arg Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys 
    290                 295                 300                 


Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu 
305                 310                 315                 320 


Gln Glu Met His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu 
                325                 330                 335     


Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln 
            340                 345                 350         


Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro 
        355                 360                 365             


Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg 
    370                 375                 380                 


Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala 
385                 390                 395                 400 


Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val 
                405                 410                 415     


Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr 
            420                 425                 430         


Ser Ala Gly His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val 
        435                 440                 445             


Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala 
    450                 455                 460                 


Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp 
465                 470                 475                 480 


Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala 
                485                 490                 495     


Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp 
            500                 505                 510         


Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu 
        515                 520                 525             


Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr 
    530                 535                 540                 


Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn 
545                 550                 555                 560 


Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser 
                565                 570                 575     


Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn 
            580                 585                 590         


Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn 
        595                 600                 605             


Gly Ile Asp Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr 
    610                 615                 620                 


Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp 
625                 630                 635                 640 


Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr 
                645                 650                 655     


Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro 
            660                 665                 670         


Lys Ala Ser Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe 
        675                 680                 685             


<210>  28
<211>  1149
<212>  PRT
<213>  Homo Sapiens

<400>  28

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gln Gly Thr Phe Pro 
                245                 250                 255     


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
            260                 265                 270         


Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
        275                 280                 285             


His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro 
    290                 295                 300                 


Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser 
305                 310                 315                 320 


Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu 
                325                 330                 335     


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
            340                 345                 350         


Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
        355                 360                 365             


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
    370                 375                 380                 


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly 
385                 390                 395                 400 


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
                405                 410                 415     


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
            420                 425                 430         


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
        435                 440                 445             


Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn 
    450                 455                 460                 


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
465                 470                 475                 480 


Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp 
                485                 490                 495     


Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys 
            500                 505                 510         


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp 
        515                 520                 525             


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro 
    530                 535                 540                 


Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe 
545                 550                 555                 560 


Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
                565                 570                 575     


His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
            580                 585                 590         


Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu 
        595                 600                 605             


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
    610                 615                 620                 


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys 
625                 630                 635                 640 


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
                645                 650                 655     


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
            660                 665                 670         


Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala 
        675                 680                 685             


Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Gln Gly Thr Phe 
    690                 695                 700                 


Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu 
705                 710                 715                 720 


Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe 
                725                 730                 735     


Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu 
            740                 745                 750         


Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala 
        755                 760                 765             


Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu 
    770                 775                 780                 


Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu 
785                 790                 795                 800 


Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr 
                805                 810                 815     


Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val 
            820                 825                 830         


Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly 
        835                 840                 845             


Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu 
    850                 855                 860                 


Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile 
865                 870                 875                 880 


Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu 
                885                 890                 895     


Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His 
            900                 905                 910         


Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser 
        915                 920                 925             


Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His 
    930                 935                 940                 


Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln 
945                 950                 955                 960 


Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile 
                965                 970                 975     


Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu 
            980                 985                 990         


Pro Asp Phe Thr Glu Ser Glu Lys  Lys Phe Ile Lys Gly  Thr Ala Asp 
        995                 1000                 1005             


Phe Phe  Ala Leu Cys Phe Gly  Pro Thr Leu Ser Phe  Gln Leu Leu 
    1010                 1015                 1020             


Asp Pro  His Met Lys Phe Arg  Gln Leu Glu Ser Pro  Asn Leu Arg 
    1025                 1030                 1035             


Gln Leu  Leu Ser Trp Ile Asp  Leu Glu Phe Asn His  Pro Gln Ile 
    1040                 1045                 1050             


Phe Ile  Val Glu Asn Gly Trp  Phe Val Ser Gly Thr  Thr Lys Arg 
    1055                 1060                 1065             


Asp Asp  Ala Lys Tyr Met Tyr  Tyr Leu Lys Lys Phe  Ile Met Glu 
    1070                 1075                 1080             


Thr Leu  Lys Ala Ile Lys Leu  Asp Gly Val Asp Val  Ile Gly Tyr 
    1085                 1090                 1095             


Thr Ala  Trp Ser Leu Met Asp  Gly Phe Glu Trp His  Arg Gly Tyr 
    1100                 1105                 1110             


Ser Ile  Arg Arg Gly Leu Phe  Tyr Val Asp Phe Leu  Ser Gln Asp 
    1115                 1120                 1125             


Lys Met  Leu Leu Pro Lys Ser  Ser Ala Leu Phe Tyr  Gln Lys Leu 
    1130                 1135                 1140             


Ile Glu  Lys Asn Gly Phe 
    1145                 


<210>  29
<211>  1125
<212>  PRT
<213>  Homo Sapiens

<400>  29

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Thr Phe Pro Cys 
                245                 250                 255     


Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr 
            260                 265                 270         


Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His 
        275                 280                 285             


Ser Lys Arg Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys 
    290                 295                 300                 


Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu 
305                 310                 315                 320 


Gln Glu Met His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu 
                325                 330                 335     


Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln 
            340                 345                 350         


Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro 
        355                 360                 365             


Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg 
    370                 375                 380                 


Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala 
385                 390                 395                 400 


Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val 
                405                 410                 415     


Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr 
            420                 425                 430         


Ser Ala Gly His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val 
        435                 440                 445             


Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala 
    450                 455                 460                 


Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp 
465                 470                 475                 480 


Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala 
                485                 490                 495     


Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp 
            500                 505                 510         


Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu 
        515                 520                 525             


Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr 
    530                 535                 540                 


Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn 
545                 550                 555                 560 


Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser 
                565                 570                 575     


Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn 
            580                 585                 590         


Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn 
        595                 600                 605             


Gly Ile Asp Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr 
    610                 615                 620                 


Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp 
625                 630                 635                 640 


Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr 
                645                 650                 655     


Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro 
            660                 665                 670         


Lys Ala Ser Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe 
        675                 680                 685             


Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile 
    690                 695                 700                 


Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr Leu 
705                 710                 715                 720 


Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val Val 
                725                 730                 735     


Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro 
            740                 745                 750         


Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe Ser 
        755                 760                 765             


Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn 
    770                 775                 780                 


His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg 
785                 790                 795                 800 


Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn 
                805                 810                 815     


Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro 
            820                 825                 830         


Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu 
        835                 840                 845             


Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr 
    850                 855                 860                 


Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His Ala 
865                 870                 875                 880 


Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly 
                885                 890                 895     


Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro 
            900                 905                 910         


Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp 
        915                 920                 925             


Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp 
    930                 935                 940                 


Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr 
945                 950                 955                 960 


Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu 
                965                 970                 975     


Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp 
            980                 985                 990         


Pro Ile Lys Tyr Asn Asp Tyr Leu  Glu Val Gln Glu Met  Thr Asp Ile 
        995                 1000                 1005             


Thr Trp  Leu Asn Ser Pro Ser  Gln Val Ala Val Val  Pro Trp Gly 
    1010                 1015                 1020             


Leu Arg  Lys Val Leu Asn Trp  Leu Lys Phe Lys Tyr  Gly Asp Leu 
    1025                 1030                 1035             


Pro Met  Tyr Ile Ile Ser Asn  Gly Ile Asp Asp Gly  Leu His Ala 
    1040                 1045                 1050             


Glu Asp  Asp Gln Leu Arg Val  Tyr Tyr Met Gln Asn  Tyr Ile Asn 
    1055                 1060                 1065             


Glu Ala  Leu Lys Ala His Ile  Leu Asp Gly Ile Asn  Leu Cys Gly 
    1070                 1075                 1080             


Tyr Phe  Ala Tyr Ser Phe Asn  Asp Arg Thr Ala Pro  Arg Phe Gly 
    1085                 1090                 1095             


Leu Tyr  Arg Tyr Ala Ala Asp  Gln Phe Glu Pro Lys  Ala Ser Met 
    1100                 1105                 1110             


Lys His  Tyr Arg Lys Ile Ile  Asp Ser Asn Gly Phe  
    1115                 1120                 1125 


<210>  30
<211>  2157
<212>  DNA
<213>  Homo Sapiens

<400>  30
gctcccagcc aagaacctcg gggccgctgc gcggtgggga ggagttcccc gaaacccggc     60

cgctaagcga ggcctcctcc tcccgcagat ccgaacggcc tgggcggggt caccccggct    120

gggacaagaa gccgccgcct gcctgcccgg gcccggggag ggggctgggg ctggggccgg    180

aggcggggtg tgagtgggtg tgtgcggggg gcggaggctt gatgcaatcc cgataagaaa    240

tgctcgggtg tcttgggcac ctacccgtgg ggcccgtaag gcgctactat ataaggctgc    300

cggcccggag ccgccgcgcc gtcagagcag gagcgctgcg tccaggatct agggccacga    360

ccatcccaac ccggcactca cagccccgca gcgcatcccg gtcgccgccc agcctcccgc    420

acccccatcg ccggagctgc gccgagagcc ccagggaggt gccatgcgga gcgggtgtgt    480

ggtggtccac gtatggatcc tggccggcct ctggctggcc gtggccgggc gccccctcgc    540

cttctcggac gcggggcccc acgtgcacta cggctggggc gaccccatcc gcctgcggca    600

cctgtacacc tccggccccc acgggctctc cagctgcttc ctgcgcatcc gtgccgacgg    660

cgtcgtggac tgcgcgcggg gccagagcgc gcacagtttg ctggagatca aggcagtcgc    720

tctgcggacc gtggccatca agggcgtgca cagcgtgcgg tacctctgca tgggcgccga    780

cggcaagatg caggggctgc ttcagtactc ggaggaagac tgtgctttcg aggaggagat    840

ccgcccagat ggctacaatg tgtaccgatc cgagaagcac cgcctcccgg tctccctgag    900

cagtgccaaa cagcggcagc tgtacaagaa cagaggcttt cttccactct ctcatttcct    960

gcccatgctg cccatggtcc cagaggagcc tgaggacctc aggggccact tggaatctga   1020

catgttctct tcgcccctgg agaccgacag catggaccca tttgggcttg tcaccggact   1080

ggaggccgtg aggagtccca gctttgagaa gtaactgaga ccatgcccgg gcctcttcac   1140

tgctgccagg ggctgtggta cctgcagcgt gggggacgtg cttctacaag aacagtcctg   1200

agtccacgtt ctgtttagct ttaggaagaa acatctagaa gttgtacata ttcagagttt   1260

tccattggca gtgccagttt ctagccaata gacttgtctg atcataacat tgtaagcctg   1320

tagcttgccc agctgctgcc tgggccccca ttctgctccc tcgaggttgc tggacaagct   1380

gctgcactgt ctcagttctg cttgaatacc tccatcgatg gggaactcac ttcctttgga   1440

aaaattctta tgtcaagctg aaattctcta attttttctc atcacttccc caggagcagc   1500

cagaagacag gcagtagttt taatttcagg aacaggtgat ccactctgta aaacagcagg   1560

taaatttcac tcaaccccat gtgggaattg atctatatct ctacttccag ggaccatttg   1620

cccttcccaa atccctccag gccagaactg actggagcag gcatggccca ccaggcttca   1680

ggagtagggg aagcctggag ccccactcca gccctgggac aacttgagaa ttccccctga   1740

ggccagttct gtcatggatg ctgtcctgag aataacttgc tgtcccggtg tcacctgctt   1800

ccatctccca gcccaccagc cctctgccca cctcacatgc ctccccatgg attggggcct   1860

cccaggcccc ccaccttatg tcaacctgca cttcttgttc aaaaatcagg aaaagaaaag   1920

atttgaagac cccaagtctt gtcaataact tgctgtgtgg aagcagcggg ggaagaccta   1980

gaaccctttc cccagcactt ggttttccaa catgatattt atgagtaatt tattttgata   2040

tgtacatctc ttattttctt acattattta tgcccccaaa ttatatttat gtatgtaagt   2100

gaggtttgtt ttgtatatta aaatggagtt tgtttgtaaa aaaaaaaaaa aaaaaaa      2157


<210>  31
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  31

Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210>  32
<211>  940
<212>  PRT
<213>  Homo Sapiens

<400>  32

Cys Thr Gly Thr Cys Ala Gly Cys Thr Gly Ala Gly Gly Ala Thr Cys 
1               5                   10                  15      


Cys Ala Gly Cys Cys Gly Ala Ala Ala Gly Ala Gly Gly Ala Gly Cys 
            20                  25                  30          


Cys Ala Gly Gly Cys Ala Cys Thr Cys Ala Gly Gly Cys Cys Ala Cys 
        35                  40                  45              


Cys Thr Gly Ala Gly Thr Cys Thr Ala Cys Thr Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Gly Ala Cys Ala Ala Cys Thr Gly Gly Ala Ala Thr Cys Thr Gly 
65                  70                  75                  80  


Gly Cys Ala Cys Cys Ala Ala Thr Thr Cys Thr Ala Ala Ala Cys Cys 
                85                  90                  95      


Ala Cys Thr Cys Ala Gly Cys Thr Thr Cys Thr Cys Cys Gly Ala Gly 
            100                 105                 110         


Cys Thr Cys Ala Cys Ala Cys Cys Cys Cys Gly Gly Ala Gly Ala Thr 
        115                 120                 125             


Cys Ala Cys Cys Thr Gly Ala Gly Gly Ala Cys Cys Cys Gly Ala Gly 
    130                 135                 140                 


Cys Cys Ala Thr Thr Gly Ala Thr Gly Gly Ala Cys Thr Cys Gly Gly 
145                 150                 155                 160 


Ala Cys Gly Ala Gly Ala Cys Cys Gly Gly Gly Thr Thr Cys Gly Ala 
                165                 170                 175     


Gly Cys Ala Cys Thr Cys Ala Gly Gly Ala Cys Thr Gly Thr Gly Gly 
            180                 185                 190         


Gly Thr Thr Thr Cys Thr Gly Thr Gly Cys Thr Gly Gly Cys Thr Gly 
        195                 200                 205             


Gly Thr Cys Thr Thr Cys Thr Gly Cys Thr Gly Gly Gly Ala Gly Cys 
    210                 215                 220                 


Cys Thr Gly Cys Cys Ala Gly Gly Cys Ala Cys Ala Cys Cys Cys Cys 
225                 230                 235                 240 


Ala Thr Cys Cys Cys Thr Gly Ala Cys Thr Cys Cys Ala Gly Thr Cys 
                245                 250                 255     


Cys Thr Cys Thr Cys Cys Thr Gly Cys Ala Ala Thr Thr Cys Gly Gly 
            260                 265                 270         


Gly Gly Gly Cys Cys Ala Ala Gly Thr Cys Cys Gly Gly Cys Ala Gly 
        275                 280                 285             


Cys Gly Gly Thr Ala Cys Cys Thr Cys Thr Ala Cys Ala Cys Ala Gly 
    290                 295                 300                 


Ala Thr Gly Ala Thr Gly Cys Cys Cys Ala Gly Cys Ala Gly Ala Cys 
305                 310                 315                 320 


Ala Gly Ala Ala Gly Cys Cys Cys Ala Cys Cys Thr Gly Gly Ala Gly 
                325                 330                 335     


Ala Thr Cys Ala Gly Gly Gly Ala Gly Gly Ala Thr Gly Gly Gly Ala 
            340                 345                 350         


Cys Gly Gly Thr Gly Gly Gly Gly Gly Gly Cys Gly Cys Thr Gly Cys 
        355                 360                 365             


Thr Gly Ala Cys Cys Ala Gly Ala Gly Cys Cys Cys Cys Gly Ala Ala 
    370                 375                 380                 


Ala Gly Thr Cys Thr Cys Cys Thr Gly Cys Ala Gly Cys Thr Gly Ala 
385                 390                 395                 400 


Ala Ala Gly Cys Cys Thr Thr Gly Ala Ala Gly Cys Cys Gly Gly Gly 
                405                 410                 415     


Ala Gly Thr Thr Ala Thr Thr Cys Ala Ala Ala Thr Cys Thr Thr Gly 
            420                 425                 430         


Gly Gly Ala Gly Thr Cys Ala Ala Gly Ala Cys Ala Thr Cys Cys Ala 
        435                 440                 445             


Gly Gly Thr Thr Cys Cys Thr Gly Thr Gly Cys Cys Ala Gly Cys Gly 
    450                 455                 460                 


Gly Cys Cys Ala Gly Ala Thr Gly Gly Gly Gly Cys Cys Cys Thr Gly 
465                 470                 475                 480 


Thr Ala Thr Gly Gly Ala Thr Cys Gly Cys Thr Cys Cys Ala Cys Thr 
                485                 490                 495     


Thr Thr Gly Ala Cys Cys Cys Thr Gly Ala Gly Gly Cys Cys Thr Gly 
            500                 505                 510         


Cys Ala Gly Cys Thr Thr Cys Cys Gly Gly Gly Ala Gly Cys Thr Gly 
        515                 520                 525             


Cys Thr Thr Cys Thr Thr Gly Ala Gly Gly Ala Cys Gly Gly Ala Thr 
    530                 535                 540                 


Ala Cys Ala Ala Thr Gly Thr Thr Thr Ala Cys Cys Ala Gly Thr Cys 
545                 550                 555                 560 


Cys Gly Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Cys Cys Thr Cys 
                565                 570                 575     


Cys Cys Gly Cys Thr Gly Cys Ala Cys Cys Thr Gly Cys Cys Ala Gly 
            580                 585                 590         


Gly Gly Ala Ala Cys Ala Ala Gly Thr Cys Cys Cys Cys Ala Cys Ala 
        595                 600                 605             


Cys Cys Gly Gly Gly Ala Cys Cys Cys Thr Gly Cys Ala Cys Cys Cys 
    610                 615                 620                 


Cys Gly Ala Gly Gly Ala Cys Cys Ala Gly Cys Thr Cys Gly Cys Thr 
625                 630                 635                 640 


Thr Cys Cys Thr Gly Cys Cys Ala Cys Thr Ala Cys Cys Ala Gly Gly 
                645                 650                 655     


Cys Cys Thr Gly Cys Cys Cys Cys Cys Cys Gly Cys Ala Cys Thr Cys 
            660                 665                 670         


Cys Cys Gly Gly Ala Gly Cys Cys Ala Cys Cys Cys Gly Gly Ala Ala 
        675                 680                 685             


Thr Cys Cys Thr Gly Gly Cys Cys Cys Cys Cys Cys Ala Gly Cys Cys 
    690                 695                 700                 


Cys Cys Cys Cys Gly Ala Thr Gly Thr Gly Gly Gly Cys Thr Cys Cys 
705                 710                 715                 720 


Thr Cys Gly Gly Ala Cys Cys Cys Thr Cys Thr Gly Ala Gly Cys Ala 
                725                 730                 735     


Thr Gly Gly Thr Gly Gly Gly Ala Cys Cys Thr Thr Cys Cys Cys Ala 
            740                 745                 750         


Gly Gly Gly Cys Cys Gly Ala Ala Gly Cys Cys Cys Cys Ala Gly Cys 
        755                 760                 765             


Thr Ala Cys Gly Cys Thr Thr Cys Cys Thr Gly Ala Ala Gly Cys Cys 
    770                 775                 780                 


Ala Gly Ala Gly Gly Cys Thr Gly Thr Thr Thr Ala Cys Thr Ala Thr 
785                 790                 795                 800 


Gly Ala Cys Ala Thr Cys Thr Cys Cys Thr Cys Thr Thr Thr Ala Thr 
                805                 810                 815     


Thr Thr Ala Thr Thr Ala Gly Gly Thr Thr Ala Thr Thr Thr Ala Thr 
            820                 825                 830         


Cys Thr Thr Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Thr Thr Ala 
        835                 840                 845             


Thr Thr Thr Thr Thr Cys Thr Thr Ala Cys Thr Thr Gly Ala Gly Ala 
    850                 855                 860                 


Thr Ala Ala Thr Ala Ala Ala Gly Ala Gly Thr Thr Cys Cys Ala Gly 
865                 870                 875                 880 


Ala Gly Gly Ala Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                885                 890                 895     


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            900                 905                 910         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        915                 920                 925             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    930                 935                 940 


<210>  33
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  33

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  34
<211>  3018
<212>  DNA
<213>  Homo Sapiens

<400>  34
cggcaaaaag gagggaatcc agtctaggat cctcacacca gctacttgca agggagaagg     60

aaaaggccag taaggcctgg gccaggagag tcccgacagg agtgtcaggt ttcaatctca    120

gcaccagcca ctcagagcag ggcacgatgt tgggggcccg cctcaggctc tgggtctgtg    180

ccttgtgcag cgtctgcagc atgagcgtcc tcagagccta tcccaatgcc tccccactgc    240

tcggctccag ctggggtggc ctgatccacc tgtacacagc cacagccagg aacagctacc    300

acctgcagat ccacaagaat ggccatgtgg atggcgcacc ccatcagacc atctacagtg    360

ccctgatgat cagatcagag gatgctggct ttgtggtgat tacaggtgtg atgagcagaa    420

gatacctctg catggatttc agaggcaaca tttttggatc acactatttc gacccggaga    480

actgcaggtt ccaacaccag acgctggaaa acgggtacga cgtctaccac tctcctcagt    540

atcacttcct ggtcagtctg ggccgggcga agagagcctt cctgccaggc atgaacccac    600

ccccgtactc ccagttcctg tcccggagga acgagatccc cctaattcac ttcaacaccc    660

ccataccacg gcggcacacc cggagcgccg aggacgactc ggagcgggac cccctgaacg    720

tgctgaagcc ccgggcccgg atgaccccgg ccccggcctc ctgttcacag gagctcccga    780

gcgccgagga caacagcccg atggccagtg acccattagg ggtggtcagg ggcggtcgag    840

tgaacacgca cgctggggga acgggcccgg aaggctgccg ccccttcgcc aagttcatct    900

agggtcgctg gaagggcacc ctctttaacc catccctcag caaacgcagc tcttcccaag    960

gaccaggtcc cttgacgttc cgaggatggg aaaggtgaca ggggcatgta tggaatttgc   1020

tgcttctctg gggtcccttc cacaggaggt cctgtgagaa ccaacctttg aggcccaagt   1080

catggggttt caccgccttc ctcactccat atagaacacc tttcccaata ggaaacccca   1140

acaggtaaac tagaaatttc cccttcatga aggtagagag aaggggtctc tcccaacata   1200

tttctcttcc ttgtgcctct cctctttatc acttttaagc ataaaaaaaa aaaaaaaaaa   1260

aaaaaaaaaa aaaagcagtg ggttcctgag ctcaagactt tgaaggtgta gggaagagga   1320

aatcggagat cccagaagct tctccactgc cctatgcatt tatgttagat gccccgatcc   1380

cactggcatt tgagtgtgca aaccttgaca ttaacagctg aatggggcaa gttgatgaaa   1440

acactacttt caagccttcg ttcttccttg agcatctctg gggaagagct gtcaaaagac   1500

tggtggtagg ctggtgaaaa cttgacagct agacttgatg cttgctgaaa tgaggcagga   1560

atcataatag aaaactcagc ctccctacag ggtgagcacc ttctgtctcg ctgtctccct   1620

ctgtgcagcc acagccagag ggcccagaat ggccccactc tgttcccaag cagttcatga   1680

tacagcctca ccttttggcc ccatctctgg tttttgaaaa tttggtctaa ggaataaata   1740

gcttttacac tggctcacga aaatctgccc tgctagaatt tgcttttcaa aatggaaata   1800

aattccaact ctcctaagag gcatttaatt aaggctctac ttccaggttg agtaggaatc   1860

cattctgaac aaactacaaa aatgtgactg ggaagggggc tttgagagac tgggactgct   1920

ctgggttagg ttttctgtgg actgaaaaat cgtgtccttt tctctaaatg aagtggcatc   1980

aaggactcag ggggaaagaa atcaggggac atgttataga agttatgaaa agacaaccac   2040

atggtcaggc tcttgtctgt ggtctctagg gctctgcagc agcagtggct cttcgattag   2100

ttaaaactct cctaggctga cacatctggg tctcaatccc cttggaaatt cttggtgcat   2160

taaatgaagc cttaccccat tactgcggtt cttcctgtaa gggggctcca ttttcctccc   2220

tctctttaaa tgaccaccta aaggacagta tattaacaag caaagtcgat tcaacaacag   2280

cttcttccca gtcacttttt tttttctcac tgccatcaca tactaacctt atactttgat   2340

ctattctttt tggttatgag agaaatgttg ggcaactgtt tttacctgat ggttttaagc   2400

tgaacttgaa ggactggttc ctattctgaa acagtaaaac tatgtataat agtatatagc   2460

catgcatggc aaatatttta atatttctgt tttcatttcc tgttggaaat attatcctgc   2520

ataatagcta ttggaggctc ctcagtgaaa gatcccaaaa ggattttggt ggaaaactag   2580

ttgtaatctc acaaactcaa cactaccatc aggggttttc tttatggcaa agccaaaata   2640

gctcctacaa tttcttatat ccctcgtcat gtggcagtat ttatttattt atttggaagt   2700

ttgcctatcc ttctatattt atagatattt ataaaaatgt aacccctttt tcctttcttc   2760

tgtttaaaat aaaaataaaa tttatctcag cttctgttag cttatcctct ttgtagtact   2820

acttaaaagc atgtcggaat ataagaataa aaaggattat gggaggggaa cattagggaa   2880

atccagagaa ggcaaaattg aaaaaaagat tttagaattt taaaattttc aaagatttct   2940

tccattcata aggagactca atgattttaa ttgatctaga cagaattatt taagttttat   3000

caatattgga tttctggt                                                 3018


<210>  35
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  35

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  36
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  36

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  37
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  37

Tyr Asp Thr Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala 
1               5                   10                  15      


Leu Gln Val Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile 
            20                  25                  30          


Trp Asp His Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn 
        35                  40                  45              


Gly Ser Ser Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu 
    50                  55                  60                  


Asp Phe Ile Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg 
65                  70                  75                  80  


Leu Phe Pro Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro 
            100                 105                 110         


Ile Val Thr Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys 
        115                 120                 125             


Tyr Gly Gly Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr 
    130                 135                 140                 


Ala Thr Tyr Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile 
145                 150                 155                 160 


Thr Ile His Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly 
                165                 170                 175     


Met His Ala Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val 
            180                 185                 190         


Gly His Asn Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn 
        195                 200                 205             


Thr His Phe Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly 
    210                 215                 220                 


Ser His Trp Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe 
225                 230                 235                 240 


Lys Cys Gln Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro 
                245                 250                 255     


Ile His Gly Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe 
            260                 265                 270         


Ser Val Leu Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly 
        275                 280                 285             


Thr Ala Asp Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro 
    290                 295                 300                 


Leu Asn Thr Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg 
305                 310                 315                 320 


Glu Ala Leu Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu 
                325                 330                 335     


Ile Ala Glu Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp 
            340                 345                 350         


Thr Thr Ala Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln 
        355                 360                 365             


Ala Ile Arg Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser 
    370                 375                 380                 


Leu Leu Asp Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly 
385                 390                 395                 400 


Leu Phe Tyr Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys 
                405                 410                 415     


Ser Ser Ala His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe 
            420                 425                 430     


<210>  38
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  38

Thr Arg Pro Ala Gln Cys Thr Asp Phe Val Asn Ile Lys Lys Gln Leu 
1               5                   10                  15      


Glu Met Leu Ala Arg Met Lys Val Thr His Tyr Arg Phe Ala Leu Asp 
            20                  25                  30          


Trp Ala Ser Val Leu Pro Thr Gly Asn Leu Ser Ala Val Asn Arg Gln 
        35                  40                  45              


Ala Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly Leu Lys Leu Gly 
    50                  55                  60                  


Ile Ser Ala Met Val Thr Leu Tyr Tyr Pro Thr His Ala His Leu Gly 
65                  70                  75                  80  


Leu Pro Glu Pro Leu Leu His Ala Asp Gly Trp Leu Asn Pro Ser Thr 
                85                  90                  95      


Ala Glu Ala Phe Gln Ala Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly 
            100                 105                 110         


Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser 
        115                 120                 125             


Asp Ile Tyr Asn Arg Ser Gly Asn Asp Thr Tyr Gly Ala Ala His Asn 
    130                 135                 140                 


Leu Leu Val Ala His Ala Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe 
145                 150                 155                 160 


Arg Pro Ser Gln Arg Gly Ala Val Ser Leu Ser Leu His Ala Asp Trp 
                165                 170                 175     


Ala Glu Pro Ala Asn Pro Tyr Ala Asp Ser His Trp Arg Ala Ala Glu 
            180                 185                 190         


Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys 
        195                 200                 205             


Thr Gly Asp Tyr Pro Ala Ala Met Arg Glu Tyr Ile Ala Ser Lys His 
    210                 215                 220                 


Arg Arg Gly Leu Ser Ser Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu 
225                 230                 235                 240 


Arg Arg Leu Leu Lys Gly Thr Val Asp Phe Cys Ala Leu Asn His Phe 
                245                 250                 255     


Thr Thr Arg Phe Val Met His Glu Gln Leu Ala Gly Ser Arg Tyr Asp 
            260                 265                 270         


Ser Asp Arg Asp Ile Gln Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser 
        275                 280                 285             


Pro Thr Arg Leu Ala Val Ile Pro Trp Gly Val Arg Lys Leu Leu Arg 
    290                 295                 300                 


Trp Val Arg Arg Asn Tyr Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser 
305                 310                 315                 320 


Gly Ile Asp Asp Gln Ala Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr 
                325                 330                 335     


Leu Gly Lys Tyr Leu Gln Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys 
            340                 345                 350         


Val Arg Ile Lys Gly Tyr Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser 
        355                 360                 365             


Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser 
    370                 375                 380                 


Ile Gln Phe Tyr Asn Lys Val Ile Ser Ser Arg Gly Phe 
385                 390                 395         


<210>  39
<211>  946
<212>  PRT
<213>  Homo Sapiens

<400>  39

Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn Pro Asn Phe 
1               5                   10                  15      


Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys 
            20                  25                  30          


Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val Glu Gly Ser 
        35                  40                  45              


Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His Phe Ile His 
    50                  55                  60                  


Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser Asp Ser Tyr 
65                  70                  75                  80  


Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile Gly Val Ser 
                85                  90                  95      


Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp Gly Ile 
            100                 105                 110         


Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser Thr Leu Leu 
        115                 120                 125             


Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His 
    130                 135                 140                 


Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp Lys Asn 
145                 150                 155                 160 


Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln 
                165                 170                 175     


Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr 
            180                 185                 190         


Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala Pro Gly Glu 
        195                 200                 205             


Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys 
    210                 215                 220                 


Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe Arg Pro His 
225                 230                 235                 240 


Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro 
                245                 250                 255     


Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln Gln Ser Met 
            260                 265                 270         


Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp 
        275                 280                 285             


Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu Pro Ile Phe 
    290                 295                 300                 


Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp Phe Phe Ala 
305                 310                 315                 320 


Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met Ala Lys 
                325                 330                 335     


Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn Trp Ile 
            340                 345                 350         


Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu Asn Gly Trp 
        355                 360                 365             


Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met 
    370                 375                 380                 


Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu Asp Glu 
385                 390                 395                 400 


Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly Phe Glu 
                405                 410                 415     


Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
            420                 425                 430         


Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr 
        435                 440                 445             


Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu Ser Thr Pro 
    450                 455                 460                 


Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu 
465                 470                 475                 480 


Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe Ser Asp 
                485                 490                 495     


Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu His Arg 
            500                 505                 510         


Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp Phe 
        515                 520                 525             


Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys Val Thr 
    530                 535                 540                 


His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn 
545                 550                 555                 560 


Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val Val 
                565                 570                 575     


Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu Tyr Tyr 
            580                 585                 590         


Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu His Ala Asp 
        595                 600                 605             


Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala Tyr Ala Gly 
    610                 615                 620                 


Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile 
625                 630                 635                 640 


Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser Gly Asn Asp 
                645                 650                 655     


Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala Leu Ala Trp 
            660                 665                 670         


Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly Ala Val Ser 
        675                 680                 685             


Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro Tyr Ala Asp 
    690                 695                 700                 


Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp 
705                 710                 715                 720 


Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala Ala Met Arg 
                725                 730                 735     


Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser Ser Ala Leu 
            740                 745                 750         


Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly Thr Val Asp 
        755                 760                 765             


Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met His Glu Gln 
    770                 775                 780                 


Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln Phe Leu Gln 
785                 790                 795                 800 


Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val Ile Pro Trp 
                805                 810                 815     


Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp Met 
            820                 825                 830         


Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala Leu Glu Asp 
        835                 840                 845             


Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val Leu 
    850                 855                 860                 


Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala Phe 
865                 870                 875                 880 


Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser 
                885                 890                 895     


Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Val Ile Ser 
            900                 905                 910         


Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys Ser Gln Thr 
        915                 920                 925             


Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val Gln Lys Lys 
    930                 935                 940                 


Pro Leu 
945     


<210>  40
<211>  1195
<212>  PRT
<213>  Homo Sapiens

<400>  40

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
945                 950                 955                 960 


Ser Gly Gly Gly Gly Ser Leu Lys Tyr Pro Asn Ala Ser Pro Leu Leu 
                965                 970                 975     


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
            980                 985                 990         


Asn Ser Tyr His Leu Gln Ile His  Lys Asn Gly His Val  Asp Gly Ala 
        995                 1000                 1005             


Pro His  Gln Thr Ile Tyr Ser  Ala Leu Met Ile Arg  Ser Glu Asp 
    1010                 1015                 1020             


Ala Gly  Phe Val Val Ile Thr  Gly Val Met Ser Arg  Arg Tyr Leu 
    1025                 1030                 1035             


Cys Met  Asp Phe Arg Gly Asn  Ile Phe Gly Ser His  Tyr Phe Asp 
    1040                 1045                 1050             


Pro Glu  Asn Cys Arg Phe Gln  His Gln Thr Leu Glu  Asn Gly Tyr 
    1055                 1060                 1065             


Asp Val  Tyr His Ser Pro Gln  Tyr His Phe Leu Val  Ser Leu Gly 
    1070                 1075                 1080             


Arg Ala  Lys Arg Ala Phe Leu  Pro Gly Met Asn Pro  Pro Pro Tyr 
    1085                 1090                 1095             


Ser Gln  Phe Leu Ser Arg Arg  Asn Glu Ile Pro Leu  Ile His Phe 
    1100                 1105                 1110             


Asn Thr  Pro Ile Pro Arg Arg  His Thr Arg Ser Ala  Glu Asp Asp 
    1115                 1120                 1125             


Ser Glu  Arg Asp Pro Leu Asn  Val Leu Lys Pro Arg  Ala Arg Met 
    1130                 1135                 1140             


Thr Pro  Ala Pro Ala Ser Cys  Ser Gln Glu Leu Pro  Ser Ala Glu 
    1145                 1150                 1155             


Asp Asn  Ser Pro Met Ala Ser  Asp Pro Leu Gly Val  Val Arg Gly 
    1160                 1165                 1170             


Gly Arg  Val Asn Thr His Ala  Gly Gly Thr Gly Pro  Glu Gly Cys 
    1175                 1180                 1185             


Arg Pro  Phe Ala Lys Phe Ile  
    1190                 1195 


<210>  41
<211>  1195
<212>  PRT
<213>  Homo Sapiens

<400>  41

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
945                 950                 955                 960 


Ser Gly Gly Gly Gly Ser Leu Lys Tyr Pro Asn Ala Ser Pro Leu Leu 
                965                 970                 975     


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
            980                 985                 990         


Asn Ser Tyr His Leu Gln Ile His  Lys Asn Gly His Val  Asp Gly Ala 
        995                 1000                 1005             


Pro His  Gln Thr Ile Tyr Ser  Ala Leu Met Ile Arg  Ser Glu Asp 
    1010                 1015                 1020             


Ala Gly  Phe Val Val Ile Thr  Gly Val Met Ser Arg  Arg Tyr Leu 
    1025                 1030                 1035             


Cys Met  Asp Phe Arg Gly Asn  Ile Phe Gly Ser His  Tyr Phe Asp 
    1040                 1045                 1050             


Pro Glu  Asn Cys Arg Phe Gln  His Gln Thr Leu Glu  Asn Gly Tyr 
    1055                 1060                 1065             


Asp Val  Tyr His Ser Pro Gln  Tyr His Phe Leu Val  Ser Leu Gly 
    1070                 1075                 1080             


Arg Ala  Lys Arg Ala Phe Leu  Pro Gly Met Asn Pro  Pro Pro Tyr 
    1085                 1090                 1095             


Ser Gln  Phe Leu Ser Arg Arg  Asn Glu Ile Pro Leu  Ile His Phe 
    1100                 1105                 1110             


Asn Thr  Pro Ile Pro Arg Arg  His Thr Gln Ser Ala  Glu Asp Asp 
    1115                 1120                 1125             


Ser Glu  Arg Asp Pro Leu Asn  Val Leu Lys Pro Arg  Ala Arg Met 
    1130                 1135                 1140             


Thr Pro  Ala Pro Ala Ser Cys  Ser Gln Glu Leu Pro  Ser Ala Glu 
    1145                 1150                 1155             


Asp Asn  Ser Pro Met Ala Ser  Asp Pro Leu Gly Val  Val Arg Gly 
    1160                 1165                 1170             


Gly Arg  Val Asn Thr His Ala  Gly Gly Thr Gly Pro  Glu Gly Cys 
    1175                 1180                 1185             


Arg Pro  Phe Ala Lys Phe Ile  
    1190                 1195 


<210>  42
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  42

Tyr Pro Asn Ala Ser Pro Leu Leu Gly Ser Ser Trp Gly Gly Leu Ile 
1               5                   10                  15      


His Leu Tyr Thr Ala Thr Ala Arg Asn Ser Tyr His Leu Gln Ile His 
            20                  25                  30          


Lys Asn Gly His Val Asp Gly Ala Pro His Gln Thr Ile Tyr Ser Ala 
        35                  40                  45              


Leu Met Ile Arg Ser Glu Asp Ala Gly Phe Val Val Ile Thr Gly Val 
    50                  55                  60                  


Met Ser Arg Arg Tyr Leu Cys Met Asp Phe Arg Gly Asn Ile Phe Gly 
65                  70                  75                  80  


Ser His Tyr Phe Asp Pro Glu Asn Cys Arg Phe Gln His Gln Thr Leu 
                85                  90                  95      


Glu Asn Gly Tyr Asp Val Tyr His Ser Pro Gln Tyr His Phe Leu Val 
            100                 105                 110         


Ser Leu Gly Arg Ala Lys Arg Ala Phe Leu Pro Gly Met Asn Pro Pro 
        115                 120                 125             


Pro Tyr Ser Gln Phe Leu Ser Arg Arg Asn Glu Ile Pro Leu Ile His 
    130                 135                 140                 


Phe Asn Thr Pro Ile Pro Arg Arg His Thr Arg Ser Ala Glu Asp Asp 
145                 150                 155                 160 


Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr 
                165                 170                 175     


Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn 
            180                 185                 190         


Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val 
        195                 200                 205             


Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala 
    210                 215                 220                 


Lys Phe Ile 
225         


<210>  43
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  43

Tyr Pro Asn Ala Ser Pro Leu Leu Gly Ser Ser Trp Gly Gly Leu Ile 
1               5                   10                  15      


His Leu Tyr Thr Ala Thr Ala Arg Asn Ser Tyr His Leu Gln Ile His 
            20                  25                  30          


Lys Asn Gly His Val Asp Gly Ala Pro His Gln Thr Ile Tyr Ser Ala 
        35                  40                  45              


Leu Met Ile Arg Ser Glu Asp Ala Gly Phe Val Val Ile Thr Gly Val 
    50                  55                  60                  


Met Ser Arg Arg Tyr Leu Cys Met Asp Phe Arg Gly Asn Ile Phe Gly 
65                  70                  75                  80  


Ser His Tyr Phe Asp Pro Glu Asn Cys Arg Phe Gln His Gln Thr Leu 
                85                  90                  95      


Glu Asn Gly Tyr Asp Val Tyr His Ser Pro Gln Tyr His Phe Leu Val 
            100                 105                 110         


Ser Leu Gly Arg Ala Lys Arg Ala Phe Leu Pro Gly Met Asn Pro Pro 
        115                 120                 125             


Pro Tyr Ser Gln Phe Leu Ser Arg Arg Asn Glu Ile Pro Leu Ile His 
    130                 135                 140                 


Phe Asn Thr Pro Ile Pro Arg Arg His Thr Gln Ser Ala Glu Asp Asp 
145                 150                 155                 160 


Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr 
                165                 170                 175     


Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn 
            180                 185                 190         


Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val 
        195                 200                 205             


Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala 
    210                 215                 220                 


Lys Phe Ile 
225         


<210>  44
<211>  982
<212>  PRT
<213>  Homo Sapiens

<400>  44

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu 
            980         


<210>  45
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  45

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Leu Gly Gly Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln 
            20                  25                  30          


Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu 
        35                  40                  45              


Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala 
    50                  55                  60                  


Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser 
65                  70                  75                  80  


Ile Trp Asp Thr Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser 
                85                  90                  95      


Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala 
            100                 105                 110         


Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr 
        115                 120                 125             


Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser 
    130                 135                 140                 


Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu 
145                 150                 155                 160 


Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly 
                165                 170                 175     


Val Gln Pro Val Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu 
            180                 185                 190         


Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe 
        195                 200                 205             


Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys 
    210                 215                 220                 


Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr 
225                 230                 235                 240 


Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly 
                245                 250                 255     


Tyr Leu Val Ala His Asn Leu Leu Leu Ala His Ala Lys Val Trp His 
            260                 265                 270         


Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile 
        275                 280                 285             


Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser 
    290                 295                 300                 


Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala 
305                 310                 315                 320 


Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn 
                325                 330                 335     


Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile 
            340                 345                 350         


Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser 
        355                 360                 365             


Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro 
    370                 375                 380                 


Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro 
385                 390                 395                 400 


Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys 
                405                 410                 415     


Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu 
            420                 425                 430         


Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr 
        435                 440                 445             


Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile 
    450                 455                 460                 


Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu 
465                 470                 475                 480 


Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn 
                485                 490                 495     


Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro 
            500                 505                 510         


Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr 
        515                 520                 525             


Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His 
    530                 535                 540                 


His Ser Lys Arg Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg 
545                 550                 555                 560 


Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu 
                565                 570                 575     


Leu Gln Glu Met His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala 
            580                 585                 590         


Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu 
        595                 600                 605             


Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr 
    610                 615                 620                 


Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro 
625                 630                 635                 640 


Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu 
                645                 650                 655     


Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His 
            660                 665                 670         


Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr 
        675                 680                 685             


Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His 
    690                 695                 700                 


Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile 
705                 710                 715                 720 


Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys 
                725                 730                 735     


Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu 
            740                 745                 750         


Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp 
        755                 760                 765             


Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp 
    770                 775                 780                 


Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His 
785                 790                 795                 800 


Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr 
                805                 810                 815     


Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn 
            820                 825                 830         


Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu 
        835                 840                 845             


Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser 
    850                 855                 860                 


Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val 
865                 870                 875                 880 


Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu 
                885                 890                 895     


Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg 
            900                 905                 910         


Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu 
        915                 920                 925             


Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly 
    930                 935                 940                 


Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr 
945                 950                 955                 960 


Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg Lys Ser Leu 
                965                 970                 


<210>  46
<211>  4380
<212>  DNA
<213>  Homo Sapiens

<400>  46
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg     60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag    120

acctgggccc gtttctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc    180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg    240

cagcagcacg gcaagggtgc gtccatctgg gatacgttca cccaccaccc cctggcaccc    300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc    360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc    420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc    480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg    540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg    600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg    660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc    720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc    780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat    840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct    900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg    960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc   1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc   1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg   1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg   1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca   1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa   1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc   1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac   1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg   1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc   1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag   1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg   1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc   1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc   1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc   1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct   1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc   1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac   2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc   2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat   2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct   2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg   2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa   2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc   2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat   2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac   2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag   2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat   2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa   2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc   2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc   2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa   2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag   2940

tctttaggat ccggaggtgg aggttcagga ggtggaggtt caggaggtgg aggttcactt   3000

aagtatccca atgcctcccc actgctcggc tccagctggg gtggcctgat ccacctgtac   3060

acagccacag ccaggaacag ctaccacctg cagatccaca agaatggcca tgtggatggc   3120

gcaccccatc agaccatcta cagtgccctg atgatcagat cagaggatgc tggctttgtg   3180

gtgattacag gtgtgatgag cagaagatac ctctgcatgg atttcagagg caacattttt   3240

ggatcacact atttcgaccc ggagaactgc aggttccaac accagacgct ggaaaacggg   3300

tacgacgtct accactctcc tcagtatcac ttcctggtca gtctgggccg ggcgaagaga   3360

gccttcctgc caggcatgaa cccacccccg tactcccagt tcctgtcccg gaggaacgag   3420

atccccctaa ttcacttcaa cacccccata ccacggcggc acacccagag cgccgaggac   3480

gactcggagc gggaccccct gaacgtgctg aagccccggg cccggatgac cccggccccg   3540

gcctcctgtt cacaggagct cccgagcgcc gaggacaaca gcccgatggc cagtgaccca   3600

ttaggggtgg tcaggggcgg tcgagtgaac acgcacgctg ggggaacggg cccggaaggc   3660

tgccgcccct tcgccaagtt catcggaggt ggaggttcaa aaacccacac gtgtcctcct   3720

tgtcctgccc cagaagcagc aggtggtcca tcagtttttc ttttccctcc caaacccaag   3780

gatacgctga tgatctctcg cacgcctgag gtgacatgcg tcgtagtaga cgtgagccac   3840

gaagatcccg aggtgaagtt caattggtat gtggacggag tagaagtgca taacgcgaaa   3900

actaagccgc gcgaggaaca atataacagt acttacaggg tggtatccgt gctcacagtc   3960

ctgcaccagg actggctgaa cggtaaggaa tacaagtgca aagtaagcaa caaggcactt   4020

cccgcgccta ttgagaaaac aatctccaag gcgaagggac aaccaagaga acctcaggtt   4080

tacactctcc cgccttccag ggaagagatg accaaaaatc aagtttccct gacttgcctc   4140

gtcaaaggat tctacccttc cgacattgct gttgaatggg aaagcaatgg acaaccagag   4200

aacaactaca agacaacacc cccggtgctg gatagtgacg gatctttctt tctctactca   4260

aagctgaccg tggataagtc caggtggcag cagggaaacg tgttttcctg ctctgtcatg   4320

catgaagcgc tgcataatca ctatacccag aagtctctga gcttgagccc aggcaagtaa   4380


<210>  47
<211>  1459
<212>  PRT
<213>  Homo Sapiens

<400>  47

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            980                 985                 990         


Gly Ser Gly Gly Gly Gly Ser Leu  Lys Tyr Pro Asn Ala  Ser Pro Leu 
        995                 1000                 1005             


Leu Gly  Ser Ser Trp Gly Gly  Leu Ile His Leu Tyr  Thr Ala Thr 
    1010                 1015                 1020             


Ala Arg  Asn Ser Tyr His Leu  Gln Ile His Lys Asn  Gly His Val 
    1025                 1030                 1035             


Asp Gly  Ala Pro His Gln Thr  Ile Tyr Ser Ala Leu  Met Ile Arg 
    1040                 1045                 1050             


Ser Glu  Asp Ala Gly Phe Val  Val Ile Thr Gly Val  Met Ser Arg 
    1055                 1060                 1065             


Arg Tyr  Leu Cys Met Asp Phe  Arg Gly Asn Ile Phe  Gly Ser His 
    1070                 1075                 1080             


Tyr Phe  Asp Pro Glu Asn Cys  Arg Phe Gln His Gln  Thr Leu Glu 
    1085                 1090                 1095             


Asn Gly  Tyr Asp Val Tyr His  Ser Pro Gln Tyr His  Phe Leu Val 
    1100                 1105                 1110             


Ser Leu  Gly Arg Ala Lys Arg  Ala Phe Leu Pro Gly  Met Asn Pro 
    1115                 1120                 1125             


Pro Pro  Tyr Ser Gln Phe Leu  Ser Arg Arg Asn Glu  Ile Pro Leu 
    1130                 1135                 1140             


Ile His  Phe Asn Thr Pro Ile  Pro Arg Arg His Thr  Gln Ser Ala 
    1145                 1150                 1155             


Glu Asp  Asp Ser Glu Arg Asp  Pro Leu Asn Val Leu  Lys Pro Arg 
    1160                 1165                 1170             


Ala Arg  Met Thr Pro Ala Pro  Ala Ser Cys Ser Gln  Glu Leu Pro 
    1175                 1180                 1185             


Ser Ala  Glu Asp Asn Ser Pro  Met Ala Ser Asp Pro  Leu Gly Val 
    1190                 1195                 1200             


Val Arg  Gly Gly Arg Val Asn  Thr His Ala Gly Gly  Thr Gly Pro 
    1205                 1210                 1215             


Glu Gly  Cys Arg Pro Phe Ala  Lys Phe Ile Gly Gly  Gly Gly Ser 
    1220                 1225                 1230             


Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Ala Ala Gly 
    1235                 1240                 1245             


Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 
    1250                 1255                 1260             


Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 
    1265                 1270                 1275             


Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 
    1280                 1285                 1290             


Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 
    1295                 1300                 1305             


Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 
    1310                 1315                 1320             


Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 
    1325                 1330                 1335             


Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 
    1340                 1345                 1350             


Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Glu 
    1355                 1360                 1365             


Glu Met  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 
    1370                 1375                 1380             


Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 
    1385                 1390                 1395             


Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 
    1400                 1405                 1410             


Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 
    1415                 1420                 1425             


Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 
    1430                 1435                 1440             


Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 
    1445                 1450                 1455             


Lys 
    


<210>  48
<211>  4353
<212>  DNA
<213>  Homo Sapiens

<400>  48
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg     60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag    120

acctgggccc gtttctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc    180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg    240

cagcagcacg gcaagggtgc gtccatctgg gatacgttca cccaccaccc cctggcaccc    300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc    360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc    420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc    480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg    540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg    600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg    660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc    720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc    780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat    840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct    900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg    960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc   1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc   1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg   1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg   1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca   1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa   1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc   1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac   1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg   1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc   1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag   1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg   1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc   1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc   1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc   1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct   1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc   1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac   2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc   2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat   2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct   2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg   2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa   2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc   2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat   2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac   2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag   2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat   2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa   2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc   2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc   2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa   2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag   2940

tctttaggat ccggaggtgg aggttcagga ggtggaggtt caggaggtgg aggttcactt   3000

aagtatccca atgcctcccc actgctcggc tccagctggg gtggcctgat ccacctgtac   3060

acagccacag ccaggaacag ctaccacctg cagatccaca agaatggcca tgtggatggc   3120

gcaccccatc agaccatcta cagtgccctg atgatcagat cagaggatgc tggctttgtg   3180

gtgattacag gtgtgatgag cagaagatac ctctgcatgg atttcagagg caacattttt   3240

ggatcacact atttcgaccc ggagaactgc aggttccaac accagacgct ggaaaacggg   3300

tacgacgtct accactctcc tcagtatcac ttcctggtca gtctgggccg ggcgaagaga   3360

gccttcctgc caggcatgaa cccacccccg tactcccagt tcctgtcccg gaggaacgag   3420

atccccctaa ttcacttcaa cacccccata ccacggcggc acacccagag cgccgaggac   3480

gactcggagc gggaccccct gaacgtgctg aagccccggg cccggatgac cccggccccg   3540

gcctcctgtt cacaggagct cccgagcgcc gaggacaaca gcccgatggc cagtgaccca   3600

ttaggggtgg tcaggggcgg tcgagtgaac acgcacgctg ggggaacggg cccggaaggc   3660

tgccgcccct tcgccaagtt catcggaggt ggaggttcag ccccagaagc agcaggtggt   3720

ccatcagttt ttcttttccc tcccaaaccc aaggatacgc tgatgatctc tcgcacgcct   3780

gaggtgacat gcgtcgtagt agacgtgagc cacgaagatc ccgaggtgaa gttcaattgg   3840

tatgtggacg gagtagaagt gcataacgcg aaaactaagc cgcgcgagga acaatataac   3900

agtacttaca gggtggtatc cgtgctcaca gtcctgcacc aggactggct gaacggtaag   3960

gaatacaagt gcaaagtaag caacaaggca cttcccgcgc ctattgagaa aacaatctcc   4020

aaggcgaagg gacaaccaag agaacctcag gtttacactc tcccgccttc cagggaagag   4080

atgaccaaaa atcaagtttc cctgacttgc ctcgtcaaag gattctaccc ttccgacatt   4140

gctgttgaat gggaaagcaa tggacaacca gagaacaact acaagacaac acccccggtg   4200

ctggatagtg acggatcttt ctttctctac tcaaagctga ccgtggataa gtccaggtgg   4260

cagcagggaa acgtgttttc ctgctctgtc atgcatgaag cgctgcataa tcactatacc   4320

cagaagtctc tgagcttgag cccaggcaag taa                                4353


<210>  49
<211>  1450
<212>  PRT
<213>  Homo Sapiens

<400>  49

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            980                 985                 990         


Gly Ser Gly Gly Gly Gly Ser Leu  Lys Tyr Pro Asn Ala  Ser Pro Leu 
        995                 1000                 1005             


Leu Gly  Ser Ser Trp Gly Gly  Leu Ile His Leu Tyr  Thr Ala Thr 
    1010                 1015                 1020             


Ala Arg  Asn Ser Tyr His Leu  Gln Ile His Lys Asn  Gly His Val 
    1025                 1030                 1035             


Asp Gly  Ala Pro His Gln Thr  Ile Tyr Ser Ala Leu  Met Ile Arg 
    1040                 1045                 1050             


Ser Glu  Asp Ala Gly Phe Val  Val Ile Thr Gly Val  Met Ser Arg 
    1055                 1060                 1065             


Arg Tyr  Leu Cys Met Asp Phe  Arg Gly Asn Ile Phe  Gly Ser His 
    1070                 1075                 1080             


Tyr Phe  Asp Pro Glu Asn Cys  Arg Phe Gln His Gln  Thr Leu Glu 
    1085                 1090                 1095             


Asn Gly  Tyr Asp Val Tyr His  Ser Pro Gln Tyr His  Phe Leu Val 
    1100                 1105                 1110             


Ser Leu  Gly Arg Ala Lys Arg  Ala Phe Leu Pro Gly  Met Asn Pro 
    1115                 1120                 1125             


Pro Pro  Tyr Ser Gln Phe Leu  Ser Arg Arg Asn Glu  Ile Pro Leu 
    1130                 1135                 1140             


Ile His  Phe Asn Thr Pro Ile  Pro Arg Arg His Thr  Gln Ser Ala 
    1145                 1150                 1155             


Glu Asp  Asp Ser Glu Arg Asp  Pro Leu Asn Val Leu  Lys Pro Arg 
    1160                 1165                 1170             


Ala Arg  Met Thr Pro Ala Pro  Ala Ser Cys Ser Gln  Glu Leu Pro 
    1175                 1180                 1185             


Ser Ala  Glu Asp Asn Ser Pro  Met Ala Ser Asp Pro  Leu Gly Val 
    1190                 1195                 1200             


Val Arg  Gly Gly Arg Val Asn  Thr His Ala Gly Gly  Thr Gly Pro 
    1205                 1210                 1215             


Glu Gly  Cys Arg Pro Phe Ala  Lys Phe Ile Gly Gly  Gly Gly Ser 
    1220                 1225                 1230             


Ala Pro  Glu Ala Ala Gly Gly  Pro Ser Val Phe Leu  Phe Pro Pro 
    1235                 1240                 1245             


Lys Pro  Lys Asp Thr Leu Met  Ile Ser Arg Thr Pro  Glu Val Thr 
    1250                 1255                 1260             


Cys Val  Val Val Asp Val Ser  His Glu Asp Pro Glu  Val Lys Phe 
    1265                 1270                 1275             


Asn Trp  Tyr Val Asp Gly Val  Glu Val His Asn Ala  Lys Thr Lys 
    1280                 1285                 1290             


Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr Arg Val  Val Ser Val 
    1295                 1300                 1305             


Leu Thr  Val Leu His Gln Asp  Trp Leu Asn Gly Lys  Glu Tyr Lys 
    1310                 1315                 1320             


Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala Pro Ile  Glu Lys Thr 
    1325                 1330                 1335             


Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu Pro Gln  Val Tyr Thr 
    1340                 1345                 1350             


Leu Pro  Pro Ser Arg Glu Glu  Met Thr Lys Asn Gln  Val Ser Leu 
    1355                 1360                 1365             


Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu 
    1370                 1375                 1380             


Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro 
    1385                 1390                 1395             


Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 
    1400                 1405                 1410             


Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 
    1415                 1420                 1425             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    1430                 1435                 1440             


Leu Ser  Leu Ser Pro Gly Lys  
    1445                 1450 


<210>  50
<211>  1449
<212>  DNA
<213>  Homo Sapiens

<400>  50
atgttggggg cccgcctcag gctctgggtc tgtgccttgt gcagcgtctg cagcatgagc     60

gtcctcagag cctatcccaa tgcctcccca ctgctcggct ccagctgggg tggcctgatc    120

cacctgtaca cagccacagc caggaacagc taccacctgc agatccacaa gaatggccat    180

gtggatggcg caccccatca gaccatctac agtgccctga tgatcagatc agaggatgct    240

ggctttgtgg tgattacagg tgtgatgagc agaagatacc tctgcatgga tttcagaggc    300

aacatttttg gatcacacta tttcgacccg gagaactgca ggttccaaca ccagacgctg    360

gaaaacgggt acgacgtcta ccactctcct cagtatcact tcctggtcag tctgggccgg    420

gcgaagagag ccttcctgcc aggcatgaac ccacccccgt actcccagtt cctgtcccgg    480

aggaacgaga tccccctaat tcacttcaac acccccatac cacggcggca cacccagagc    540

gccgaggacg actcggagcg ggaccccctg aacgtgctga agccccgggc ccggatgacc    600

ccggccccgg cctcctgttc acaggagctc ccgagcgccg aggacaacag cccgatggcc    660

agtgacccat taggggtggt caggggcggt cgagtgaaca cgcacgctgg gggaacgggc    720

ccggaaggct gccgcccctt cgccaagttc atcggaggtg gaggttcaaa aacccacacg    780

tgtcctcctt gtcctgcccc agaagcagca ggtggtccat cagtttttct tttccctccc    840

aaacccaagg atacgctgat gatctctcgc acgcctgagg tgacatgcgt cgtagtagac    900

gtgagccacg aagatcccga ggtgaagttc aattggtatg tggacggagt agaagtgcat    960

aacgcgaaaa ctaagccgcg cgaggaacaa tataacagta cttacagggt ggtatccgtg   1020

ctcacagtcc tgcaccagga ctggctgaac ggtaaggaat acaagtgcaa agtaagcaac   1080

aaggcacttc ccgcgcctat tgagaaaaca atctccaagg cgaagggaca accaagagaa   1140

cctcaggttt acactctccc gccttccagg gaagagatga ccaaaaatca agtttccctg   1200

acttgcctcg tcaaaggatt ctacccttcc gacattgctg ttgaatggga aagcaatgga   1260

caaccagaga acaactacaa gacaacaccc ccggtgctgg atagtgacgg atctttcttt   1320

ctctactcaa agctgaccgt ggataagtcc aggtggcagc agggaaacgt gttttcctgc   1380

tctgtcatgc atgaagcgct gcataatcac tatacccaga agtctctgag cttgagccca   1440

ggcaagtaa                                                           1449


<210>  51
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  51

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  52
<211>  1422
<212>  DNA
<213>  Homo Sapiens

<400>  52
atgttggggg cccgcctcag gctctgggtc tgtgccttgt gcagcgtctg cagcatgagc     60

gtcctcagag cctatcccaa tgcctcccca ctgctcggct ccagctgggg tggcctgatc    120

cacctgtaca cagccacagc caggaacagc taccacctgc agatccacaa gaatggccat    180

gtggatggcg caccccatca gaccatctac agtgccctga tgatcagatc agaggatgct    240

ggctttgtgg tgattacagg tgtgatgagc agaagatacc tctgcatgga tttcagaggc    300

aacatttttg gatcacacta tttcgacccg gagaactgca ggttccaaca ccagacgctg    360

gaaaacgggt acgacgtcta ccactctcct cagtatcact tcctggtcag tctgggccgg    420

gcgaagagag ccttcctgcc aggcatgaac ccacccccgt actcccagtt cctgtcccgg    480

aggaacgaga tccccctaat tcacttcaac acccccatac cacggcggca cacccagagc    540

gccgaggacg actcggagcg ggaccccctg aacgtgctga agccccgggc ccggatgacc    600

ccggccccgg cctcctgttc acaggagctc ccgagcgccg aggacaacag cccgatggcc    660

agtgacccat taggggtggt caggggcggt cgagtgaaca cgcacgctgg gggaacgggc    720

ccggaaggct gccgcccctt cgccaagttc atcggaggtg gaggttcagc cccagaagca    780

gcaggtggtc catcagtttt tcttttccct cccaaaccca aggatacgct gatgatctct    840

cgcacgcctg aggtgacatg cgtcgtagta gacgtgagcc acgaagatcc cgaggtgaag    900

ttcaattggt atgtggacgg agtagaagtg cataacgcga aaactaagcc gcgcgaggaa    960

caatataaca gtacttacag ggtggtatcc gtgctcacag tcctgcacca ggactggctg   1020

aacggtaagg aatacaagtg caaagtaagc aacaaggcac ttcccgcgcc tattgagaaa   1080

acaatctcca aggcgaaggg acaaccaaga gaacctcagg tttacactct cccgccttcc   1140

agggaagaga tgaccaaaaa tcaagtttcc ctgacttgcc tcgtcaaagg attctaccct   1200

tccgacattg ctgttgaatg ggaaagcaat ggacaaccag agaacaacta caagacaaca   1260

cccccggtgc tggatagtga cggatctttc tttctctact caaagctgac cgtggataag   1320

tccaggtggc agcagggaaa cgtgttttcc tgctctgtca tgcatgaagc gctgcataat   1380

cactataccc agaagtctct gagcttgagc ccaggcaagt aa                      1422


<210>  53
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  53

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  54
<211>  1228
<212>  PRT
<213>  Homo Sapiens

<400>  54

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            980                 985                 990         


Gly Ser Gly Gly Gly Gly Ser Leu  Lys Tyr Pro Asn Ala  Ser Pro Leu 
        995                 1000                 1005             


Leu Gly  Ser Ser Trp Gly Gly  Leu Ile His Leu Tyr  Thr Ala Thr 
    1010                 1015                 1020             


Ala Arg  Asn Ser Tyr His Leu  Gln Ile His Lys Asn  Gly His Val 
    1025                 1030                 1035             


Asp Gly  Ala Pro His Gln Thr  Ile Tyr Ser Ala Leu  Met Ile Arg 
    1040                 1045                 1050             


Ser Glu  Asp Ala Gly Phe Val  Val Ile Thr Gly Val  Met Ser Arg 
    1055                 1060                 1065             


Arg Tyr  Leu Cys Met Asp Phe  Arg Gly Asn Ile Phe  Gly Ser His 
    1070                 1075                 1080             


Tyr Phe  Asp Pro Glu Asn Cys  Arg Phe Gln His Gln  Thr Leu Glu 
    1085                 1090                 1095             


Asn Gly  Tyr Asp Val Tyr His  Ser Pro Gln Tyr His  Phe Leu Val 
    1100                 1105                 1110             


Ser Leu  Gly Arg Ala Lys Arg  Ala Phe Leu Pro Gly  Met Asn Pro 
    1115                 1120                 1125             


Pro Pro  Tyr Ser Gln Phe Leu  Ser Arg Arg Asn Glu  Ile Pro Leu 
    1130                 1135                 1140             


Ile His  Phe Asn Thr Pro Ile  Pro Arg Arg His Thr  Gln Ser Ala 
    1145                 1150                 1155             


Glu Asp  Asp Ser Glu Arg Asp  Pro Leu Asn Val Leu  Lys Pro Arg 
    1160                 1165                 1170             


Ala Arg  Met Thr Pro Ala Pro  Ala Ser Ser Ser Gln  Glu Leu Pro 
    1175                 1180                 1185             


Ser Ala  Glu Asp Asn Ser Pro  Met Ala Ser Asp Pro  Leu Gly Val 
    1190                 1195                 1200             


Val Arg  Gly Gly Arg Val Asn  Thr His Ala Gly Gly  Thr Gly Pro 
    1205                 1210                 1215             


Glu Gly  Cys Arg Pro Phe Ala  Lys Phe Ile 
    1220                 1225             


<210>  55
<211>  1228
<212>  PRT
<213>  Homo Sapiens

<400>  55

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            980                 985                 990         


Gly Ser Gly Gly Gly Gly Ser Leu  Lys Tyr Pro Asn Ala  Ser Pro Leu 
        995                 1000                 1005             


Leu Gly  Ser Ser Trp Gly Gly  Leu Ile His Leu Tyr  Thr Ala Thr 
    1010                 1015                 1020             


Ala Arg  Asn Ser Tyr His Leu  Gln Ile His Lys Asn  Gly His Val 
    1025                 1030                 1035             


Asp Gly  Ala Pro His Gln Thr  Ile Tyr Ser Ala Leu  Met Ile Arg 
    1040                 1045                 1050             


Ser Glu  Asp Ala Gly Phe Val  Val Ile Thr Gly Val  Met Ser Arg 
    1055                 1060                 1065             


Arg Tyr  Leu Cys Met Asp Phe  Arg Gly Asn Ile Phe  Gly Ser His 
    1070                 1075                 1080             


Tyr Phe  Asp Pro Glu Asn Cys  Arg Phe Gln His Gln  Thr Leu Glu 
    1085                 1090                 1095             


Asn Gly  Tyr Asp Val Tyr His  Ser Pro Gln Tyr His  Phe Leu Val 
    1100                 1105                 1110             


Ser Leu  Gly Arg Ala Lys Arg  Ala Phe Leu Pro Gly  Met Asn Pro 
    1115                 1120                 1125             


Pro Pro  Tyr Ser Gln Phe Leu  Ser Arg Arg Asn Glu  Ile Pro Leu 
    1130                 1135                 1140             


Ile His  Phe Asn Thr Pro Ile  Pro Arg Arg His Thr  Gln Ser Ala 
    1145                 1150                 1155             


Glu Asp  Asp Ser Glu Arg Asp  Pro Leu Asn Val Leu  Lys Pro Arg 
    1160                 1165                 1170             


Ala Arg  Met Thr Pro Ala Pro  Ala Ser Cys Ser Gln  Glu Leu Pro 
    1175                 1180                 1185             


Ser Ala  Glu Asp Asn Ser Pro  Met Ala Ser Asp Pro  Leu Gly Val 
    1190                 1195                 1200             


Val Arg  Gly Gly Arg Val Asn  Thr His Ala Gly Gly  Thr Gly Pro 
    1205                 1210                 1215             


Glu Gly  Ser Arg Pro Phe Ala  Lys Phe Ile 
    1220                 1225             


<210>  56
<211>  1228
<212>  PRT
<213>  Homo Sapiens

<400>  56

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            980                 985                 990         


Gly Ser Gly Gly Gly Gly Ser Leu  Lys Tyr Pro Asn Ala  Ser Pro Leu 
        995                 1000                 1005             


Leu Gly  Ser Ser Trp Gly Gly  Leu Ile His Leu Tyr  Thr Ala Thr 
    1010                 1015                 1020             


Ala Arg  Asn Ser Tyr His Leu  Gln Ile His Lys Asn  Gly His Val 
    1025                 1030                 1035             


Asp Gly  Ala Pro His Gln Thr  Ile Tyr Ser Ala Leu  Met Ile Arg 
    1040                 1045                 1050             


Ser Glu  Asp Ala Gly Phe Val  Val Ile Thr Gly Val  Met Ser Arg 
    1055                 1060                 1065             


Arg Tyr  Leu Cys Met Asp Phe  Arg Gly Asn Ile Phe  Gly Ser His 
    1070                 1075                 1080             


Tyr Phe  Asp Pro Glu Asn Cys  Arg Phe Gln His Gln  Thr Leu Glu 
    1085                 1090                 1095             


Asn Gly  Tyr Asp Val Tyr His  Ser Pro Gln Tyr His  Phe Leu Val 
    1100                 1105                 1110             


Ser Leu  Gly Arg Ala Lys Arg  Ala Phe Leu Pro Gly  Met Asn Pro 
    1115                 1120                 1125             


Pro Pro  Tyr Ser Ala Phe Leu  Ser Arg Arg Asn Glu  Ile Pro Leu 
    1130                 1135                 1140             


Ile His  Phe Asn Thr Pro Ile  Pro Arg Arg His Thr  Gln Ser Ala 
    1145                 1150                 1155             


Glu Asp  Asp Ser Glu Arg Asp  Pro Leu Asn Val Leu  Lys Pro Arg 
    1160                 1165                 1170             


Ala Arg  Met Thr Pro Ala Pro  Ala Ser Cys Ser Gln  Glu Leu Pro 
    1175                 1180                 1185             


Ser Ala  Glu Asp Asn Ser Pro  Met Ala Ser Asp Pro  Leu Gly Val 
    1190                 1195                 1200             


Val Arg  Gly Gly Arg Val Asn  Thr His Ala Gly Gly  Thr Gly Pro 
    1205                 1210                 1215             


Glu Gly  Cys Arg Pro Phe Ala  Lys Phe Ile 
    1220                 1225             


<210>  57
<211>  1228
<212>  PRT
<213>  Homo Sapiens

<400>  57

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            980                 985                 990         


Gly Ser Gly Gly Gly Gly Ser Leu  Lys Tyr Pro Asn Ala  Ser Pro Leu 
        995                 1000                 1005             


Leu Gly  Ser Ser Trp Gly Gly  Leu Ile His Leu Tyr  Thr Ala Thr 
    1010                 1015                 1020             


Ala Arg  Asn Ser Tyr His Leu  Gln Ile His Lys Asn  Gly His Val 
    1025                 1030                 1035             


Asp Gly  Ala Pro His Gln Thr  Ile Tyr Ser Ala Leu  Met Ile Arg 
    1040                 1045                 1050             


Ser Glu  Asp Ala Gly Phe Val  Val Ile Thr Gly Val  Met Ser Arg 
    1055                 1060                 1065             


Arg Tyr  Leu Cys Met Asp Phe  Arg Gly Asn Ile Phe  Gly Ser His 
    1070                 1075                 1080             


Tyr Phe  Asp Pro Glu Asn Cys  Arg Phe Gln His Gln  Thr Leu Glu 
    1085                 1090                 1095             


Asn Gly  Tyr Asp Val Tyr His  Ser Pro Gln Tyr His  Phe Leu Val 
    1100                 1105                 1110             


Ser Leu  Gly Arg Ala Lys Arg  Ala Phe Leu Pro Gly  Met Asn Pro 
    1115                 1120                 1125             


Pro Pro  Tyr Ser Gln Phe Leu  Ser Arg Arg Asn Glu  Ile Pro Leu 
    1130                 1135                 1140             


Ile His  Phe Asn Thr Pro Ile  Pro Arg Arg His Thr  Gln Ser Ala 
    1145                 1150                 1155             


Glu Asp  Asp Ser Glu Arg Asp  Pro Leu Asn Val Leu  Lys Pro Arg 
    1160                 1165                 1170             


Ala Arg  Met Thr Pro Ala Pro  Ala Ser Ser Ser Gln  Glu Leu Pro 
    1175                 1180                 1185             


Ser Ala  Glu Asp Asn Ser Pro  Met Ala Ser Asp Pro  Leu Gly Val 
    1190                 1195                 1200             


Val Arg  Gly Gly Arg Val Asn  Thr His Ala Gly Gly  Thr Gly Pro 
    1205                 1210                 1215             


Glu Gly  Ser Arg Pro Phe Ala  Lys Phe Ile 
    1220                 1225             


<210>  58
<211>  1228
<212>  PRT
<213>  Homo Sapiens

<400>  58

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            980                 985                 990         


Gly Ser Gly Gly Gly Gly Ser Leu  Lys Tyr Pro Asn Ala  Ser Pro Leu 
        995                 1000                 1005             


Leu Gly  Ser Ser Trp Gly Gly  Leu Ile His Leu Tyr  Thr Ala Thr 
    1010                 1015                 1020             


Ala Arg  Asn Ser Tyr His Leu  Gln Ile His Lys Asn  Gly His Val 
    1025                 1030                 1035             


Asp Gly  Ala Pro His Gln Thr  Ile Tyr Ser Ala Leu  Met Ile Arg 
    1040                 1045                 1050             


Ser Glu  Asp Ala Gly Phe Val  Val Ile Thr Gly Val  Met Ser Arg 
    1055                 1060                 1065             


Arg Tyr  Leu Cys Met Asp Phe  Arg Gly Asn Ile Phe  Gly Ser His 
    1070                 1075                 1080             


Tyr Phe  Asp Pro Glu Asn Cys  Arg Phe Gln His Gln  Thr Leu Glu 
    1085                 1090                 1095             


Asn Gly  Tyr Asp Val Tyr His  Ser Pro Gln Tyr His  Phe Leu Val 
    1100                 1105                 1110             


Ser Leu  Gly Arg Ala Lys Arg  Ala Phe Leu Pro Gly  Met Asn Pro 
    1115                 1120                 1125             


Pro Pro  Tyr Ser Ala Phe Leu  Ser Arg Arg Asn Glu  Ile Pro Leu 
    1130                 1135                 1140             


Ile His  Phe Asn Thr Pro Ile  Pro Arg Arg His Thr  Gln Ser Ala 
    1145                 1150                 1155             


Glu Asp  Asp Ser Glu Arg Asp  Pro Leu Asn Val Leu  Lys Pro Arg 
    1160                 1165                 1170             


Ala Arg  Met Thr Pro Ala Pro  Ala Ser Ser Ser Gln  Glu Leu Pro 
    1175                 1180                 1185             


Ser Ala  Glu Asp Asn Ser Pro  Met Ala Ser Asp Pro  Leu Gly Val 
    1190                 1195                 1200             


Val Arg  Gly Gly Arg Val Asn  Thr His Ala Gly Gly  Thr Gly Pro 
    1205                 1210                 1215             


Glu Gly  Ser Arg Pro Phe Ala  Lys Phe Ile 
    1220                 1225             


<210>  59
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  59

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Ser Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  60
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  60

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Ser Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  61
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  61

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Ala Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  62
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  62

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Ser Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Ser Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  63
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  63

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Ala Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Ser Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Ser Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  64
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  64

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Ser Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  65
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  65

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Ser Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  66
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  66

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Ala Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  67
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  67

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Ser Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Ser Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  68
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  68

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Ala Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Gln Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Ser Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Ser Arg Pro Phe Ala Lys Phe Ile Gly Gly Gly Gly Ser 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  69
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  69

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  70
<211>  251
<212>  PRT
<213>  Macaca mulatta

<400>  70

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Ile Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asn Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Arg His Trp Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln His His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Arg Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Val Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Ala Cys Arg Pro Phe Pro Lys Phe Ile 
                245                 250     


<210>  71
<211>  245
<212>  PRT
<213>  Bos taurus

<400>  71

Met Leu Gly Ala Arg Leu Gly Leu Trp Val Cys Thr Leu Ser Cys Val 
1               5                   10                  15      


Val Gln Ala Tyr Pro Asn Ser Ser Pro Leu Leu Gly Ser Ser Trp Gly 
            20                  25                  30          


Gly Leu Thr His Leu Tyr Thr Ala Thr Ala Arg Asn Ser Tyr His Leu 
        35                  40                  45              


Gln Ile His Gly Asp Gly His Val Asp Gly Ser Pro Gln Gln Thr Val 
    50                  55                  60                  


Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala Gly Phe Val Val Ile 
65                  70                  75                  80  


Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met Asp Phe Thr Gly Asn 
                85                  90                  95      


Ile Phe Gly Ser His His Phe Ser Pro Glu Ser Cys Arg Phe Arg Gln 
            100                 105                 110         


Arg Thr Leu Glu Asn Gly Tyr Asp Val Tyr His Ser Pro Gln His Arg 
        115                 120                 125             


Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala Phe Leu Pro Gly Thr 
    130                 135                 140                 


Asn Pro Pro Pro Tyr Ala Gln Phe Leu Ser Arg Arg Asn Glu Ile Pro 
145                 150                 155                 160 


Leu Pro His Phe Ala Ala Thr Ala Arg Pro Arg Arg His Thr Arg Ser 
                165                 170                 175     


Ala His Asp Ser Gly Asp Pro Leu Ser Val Leu Lys Pro Arg Ala Arg 
            180                 185                 190         


Ala Thr Pro Val Pro Ala Ala Cys Ser Gln Glu Leu Pro Ser Ala Glu 
        195                 200                 205             


Asp Ser Gly Pro Ala Ala Ser Asp Pro Leu Gly Val Leu Arg Gly His 
    210                 215                 220                 


Arg Leu Asp Val Arg Ala Gly Ser Ala Gly Ala Glu Arg Cys Arg Pro 
225                 230                 235                 240 


Phe Pro Gly Phe Ala 
                245 


<210>  72
<211>  251
<212>  PRT
<213>  Mus musculus

<400>  72

Met Leu Gly Thr Cys Leu Arg Leu Leu Val Gly Val Leu Cys Thr Val 
1               5                   10                  15      


Cys Ser Leu Gly Thr Ala Arg Ala Tyr Pro Asp Thr Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Asn Trp Gly Ser Leu Thr His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Thr Ser Tyr His Leu Gln Ile His Arg Asp Gly His Val Asp Gly Thr 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Thr Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Ser Val Val Ile Thr Gly Ala Met Thr Arg Arg Phe Leu Cys Met 
                85                  90                  95      


Asp Leu His Gly Asn Ile Phe Gly Ser Leu His Phe Ser Pro Glu Asn 
            100                 105                 110         


Cys Lys Phe Arg Gln Trp Thr Leu Glu Asn Gly Tyr Asp Val Tyr Leu 
        115                 120                 125             


Ser Gln Lys His His Tyr Leu Val Ser Leu Gly Arg Ala Lys Arg Ile 
    130                 135                 140                 


Phe Gln Pro Gly Thr Asn Pro Pro Pro Phe Ser Gln Phe Leu Ala Arg 
145                 150                 155                 160 


Arg Asn Glu Val Pro Leu Leu His Phe Tyr Thr Val Arg Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Pro Pro Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Pro Arg Ala Thr Pro Val Pro Val Ser Cys Ser Arg 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Glu Gly Gly Pro Ala Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Leu Arg Arg Gly Arg Gly Asp Ala Arg Gly Gly Ala Gly Gly 
225                 230                 235                 240 


Ala Asp Arg Cys Arg Pro Phe Pro Arg Phe Val 
                245                 250     


<210>  73
<211>  251
<212>  PRT
<213>  Rattus norvegicus

<400>  73

Met Leu Gly Ala Cys Leu Arg Leu Leu Val Gly Ala Leu Cys Thr Val 
1               5                   10                  15      


Cys Ser Leu Gly Thr Ala Arg Ala Tyr Ser Asp Thr Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Asn Trp Gly Ser Leu Thr His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Arg Asp Gly His Val Asp Gly Thr 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Thr Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Ser Val Val Ile Ile Gly Ala Met Thr Arg Arg Phe Leu Cys Met 
                85                  90                  95      


Asp Leu Arg Gly Asn Ile Phe Gly Ser Tyr His Phe Ser Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Arg Gln Trp Thr Leu Glu Asn Gly Tyr Asp Val Tyr Leu 
        115                 120                 125             


Ser Pro Lys His His Tyr Leu Val Ser Leu Gly Arg Ser Lys Arg Ile 
    130                 135                 140                 


Phe Gln Pro Gly Thr Asn Pro Pro Pro Phe Ser Gln Phe Leu Ala Arg 
145                 150                 155                 160 


Arg Asn Glu Val Pro Leu Leu His Phe Tyr Thr Ala Arg Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Pro Pro Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Pro Arg Ala Thr Pro Ile Pro Val Ser Cys Ser Arg 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Glu Gly Gly Pro Ala Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Leu Arg Arg Gly Arg Gly Asp Ala Arg Arg Gly Ala Gly Gly 
225                 230                 235                 240 


Thr Asp Arg Cys Arg Pro Phe Pro Arg Phe Val 
                245                 250     


