                         SEQUENCE LISTING

<110>  New England Biolabs, Inc.
       Zhu, Zhenyu
       Guan, Shengxi
       Zheng, Yu
       Wang, Hua
       Quimby, Aine
       Zhang, Penghua
       Apone, Lynne
 
<120>  Compositions, Methods and Related Uses for Cleaving Modified DNA

<130>  NEB-328-PCT

<150>  61/296,630
<151>  2010-01-20

<150>  61/376,932
<151>  2010-08-25

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  948
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide

<400>  1
ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg       60

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat      120

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg      180

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa      240

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca      300

tccagtctat caattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc      360

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt      420

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa      480

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat      540

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct      600

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga      660

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag      720

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga      780

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca      840

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg      900

cgacacggaa atgttgaata ctcatactct tcctttttca atattatt                   948


<210>  2
<211>  56
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide

<400>  2
cggcgtttcc gggttccata ggctccgcca cgtactctga tgaccagggc atcaca           56


<210>  3
<211>  55
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide

<400>  3
ccatacatat cccttacttc tcctaacgtg gatgataaag gtagtttatg tggaa            55


<210>  4
<211>  55
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide

<400>  4
tccacataaa ctacctttat catccacgtt aggagaagta agggatatgt atgga            55


<210>  5
<211>  334
<212>  PRT
<213>  Bacillus megaterium

<400>  5

Met Asn Lys Tyr Asp Tyr Ile Lys Arg Gln Leu Ala Lys Thr Asn Lys 
1               5                   10                  15      


Lys Asn Asp Glu Asn Tyr Ile Val Thr Arg Ile Trp His Leu Leu Asp 
            20                  25                  30          


Asn Tyr Asp Ile Lys Ile Asn Thr Gln Gln Tyr Val Val Arg Ser Asn 
        35                  40                  45              


Lys Asn Gln Lys Ala Glu Tyr Gly Leu Ile Asp Leu Tyr Phe Pro Gln 
    50                  55                  60                  


Phe Asn Leu Ala Val Glu Ile Asp Glu Ala His His Lys Asn Asp Ile 
65                  70                  75                  80  


Asn Gln Thr Leu Asp Glu Ile Arg Lys Asn Asp Ile Val Asn Ala Leu 
                85                  90                  95      


Asp Cys Glu Phe Ile Arg Ile Asp Ala Thr Gln Ser Phe Glu Lys Ile 
            100                 105                 110         


His Glu Lys Ile Asp Gln Val Val Glu Lys Ile Asn Leu Leu Thr Lys 
        115                 120                 125             


Glu Lys Trp Phe Ile Pro Trp Asp Leu Glu Lys Glu Tyr Asp Pro Asn 
    130                 135                 140                 


Thr Tyr Ile Glu Gln Gly Tyr Ile Asp Ala Asp Asp Asn Val Ser Leu 
145                 150                 155                 160 


Arg Leu Val Ala Asp Cys Cys Asn Val Phe Gly Ala Gly Tyr Ala His 
                165                 170                 175     


Gly Ile Gln Lys Ser Gly Ala Pro His Lys Phe Glu Glu Asp Thr Asp 
            180                 185                 190         


Ile Lys Arg Leu Lys Phe Phe Pro Asn Glu Thr Trp Asn Asn Gln Leu 
        195                 200                 205             


Leu Glu Asn Glu Glu Ile Phe Ile Glu Tyr Asn Thr Ile Pro Glu Glu 
    210                 215                 220                 


Asn Glu Ala Tyr Phe Gln Lys Arg Met Tyr Gln Leu Asn Gln Lys Ile 
225                 230                 235                 240 


Ala Leu Phe Ala Tyr Ala Lys Thr Ser Ser Gly Arg Phe Glu Ala Ile 
                245                 250                 255     


Phe Lys Gly Leu Tyr Leu Leu Asn Arg Glu Lys Ser Lys Asn Thr Gly 
            260                 265                 270         


Val Leu Thr Tyr Asn Arg Ile Ser Thr Ile Met Pro Thr Tyr Tyr Pro 
        275                 280                 285             


Lys Asp Val Lys Gln Pro Leu Arg Ile Ala Glu Ala Tyr Asn Asn Asp 
    290                 295                 300                 


Glu Tyr Lys Val Ala His Phe Tyr Thr Glu Asn Gln Val Arg Lys Phe 
305                 310                 315                 320 


Glu Gly Lys Tyr Lys Lys Arg Tyr Lys Ile Ile Ser Tyr Ser 
                325                 330                 


<210>  6
<211>  309
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  6

Met Ser Gly Ala Asp Lys Leu Gly Tyr Leu Ile Arg Ala Leu Ser Arg 
1               5                   10                  15      


Thr Lys Arg Lys Asp Tyr Glu Asn Tyr Val Val Asn Ala Ile Trp Asn 
            20                  25                  30          


Arg Leu Ala Met Asp Asp Val Lys Pro Val Thr Gln Gln Leu Val Leu 
        35                  40                  45              


Trp Pro Asp Gly Arg Arg Ser Phe Val Asp Leu Tyr Phe Pro Gln Ala 
    50                  55                  60                  


Met Ile Gly Val Glu Cys Asp Glu Ala Tyr His Gln Arg Gln Arg Glu 
65                  70                  75                  80  


Arg Asp Arg Glu Arg Glu Ile Thr Ile Thr Asp Val Leu Arg Gln Ile 
                85                  90                  95      


Arg Gly Glu Asp Tyr Arg Ala Leu His Val Asp Val Ser Gly Ser Tyr 
            100                 105                 110         


Glu Gln Val Glu Arg Ser Ile Asp Asp Cys Val Arg Arg Ile Arg Ala 
        115                 120                 125             


Glu Ile Glu Arg Arg Arg Gln Ala Asn Glu Phe Thr Pro Trp Thr Glu 
    130                 135                 140                 


Ala Tyr Val Asp Tyr Lys Glu Phe Tyr Lys Thr Arg Asp Ala Val Ser 
145                 150                 155                 160 


Val Ala Asp Asp Val Gly Phe Pro Arg Ile Ala Asp Ala Val Asn Thr 
                165                 170                 175     


Leu Cys Gly Ser Glu Tyr Lys Arg Phe Gln Glu Ser Trp Phe Val Pro 
            180                 185                 190         


Ser Val Met Arg Gln Trp Tyr Gly Asp Arg Tyr Arg Val Trp Phe Pro 
        195                 200                 205             


Lys Leu Ala Ile Gly Gly Lys Ala Val Ala Asn Gly Trp Asn Asn Arg 
    210                 215                 220                 


Leu Ser Asp Asp Gly Thr Tyr Ile Tyr Glu Tyr Asn Glu Asp Ala Asp 
225                 230                 235                 240 


Leu Val Asp Pro Val Gly Asp Gly Asp Pro Asn Asp Ile Arg Ile Thr 
                245                 250                 255     


Phe Ala Lys Ser Ala Asp Pro Val Thr Arg Ile Gln Ala Tyr Arg Phe 
            260                 265                 270         


Val Gly Val Phe Arg Arg Ile Ser Asn Ser Glu Asp Gly Thr Arg Lys 
        275                 280                 285             


Arg Tyr Gln Arg Ile Glu Thr Val Phe Pro Ile His Arg Thr Pro Cys 
    290                 295                 300                 


Leu Pro Ile His Arg 
305                 


<210>  7
<211>  321
<212>  PRT
<213>  Acinetobacter baumannii

<400>  7

Met Cys Asn Lys Ala Ser Ser Asp Leu Thr Asp Tyr Val Ile Arg Gln 
1               5                   10                  15      


Leu Gly Arg Thr Lys Asn Lys Arg Tyr Glu Ala Tyr Val Val Ser Arg 
            20                  25                  30          


Ile Ile His Leu Leu Asn Asp Phe Thr Leu Lys Phe Val Thr Gln Gln 
        35                  40                  45              


Phe Val Arg Leu Ser Asn Lys Lys Ile Ala Leu Thr Asp Leu Tyr Phe 
    50                  55                  60                  


Pro Gln Leu Gly Ile His Ile Glu Val Asp Glu Gly His His Phe Leu 
65                  70                  75                  80  


Arg Asn Ser Lys Met Glu Tyr Ser Leu Asn Gln Ile Asp Glu Pro Leu 
                85                  90                  95      


Tyr Ser Ile Ser Gln Thr Glu Ser Asp Ala Met Arg Glu Glu Asp Ile 
            100                 105                 110         


Ile Ser Ile Thr Gly His Lys Ile Phe Arg Val Asn Val Phe Lys Asn 
        115                 120                 125             


Gln Glu Gly Gln Pro Gln Asn Leu Glu Asn Ile His Gln Gln Ile Asp 
    130                 135                 140                 


Lys Ile Ile Glu Glu Ile Lys Thr Ala Lys Asn Lys Leu Ile Glu Ala 
145                 150                 155                 160 


Ser Thr Phe Lys Glu Trp Asn Ile Glu Thr Glu Tyr Asn Pro Gln Thr 
                165                 170                 175     


Tyr Ile Asp Leu Gly Arg Ile Ser Leu Ala Asp Asn Val Val Leu Lys 
            180                 185                 190         


Thr Thr Lys Asp Val Cys Asn Cys Phe Gly Tyr Ser Tyr Lys Asn Tyr 
        195                 200                 205             


Gln Arg Gly Gly Ala Leu His Pro Tyr Lys Lys Asp Thr Leu Ile Trp 
    210                 215                 220                 


Phe Pro Arg Leu Tyr Glu Asn Lys Asp Trp Ile Asn Thr Ile Ser Pro 
225                 230                 235                 240 


Asp Gly Leu Thr Ile Thr Glu Lys Ser Thr Asp Glu Thr Ile Thr Leu 
                245                 250                 255     


Lys Lys Leu Glu Glu Trp Lys Asn Gly Pro Gln Lys Arg Ile Val Phe 
            260                 265                 270         


Ala Arg Val Lys Asp Asn Leu Ser Ser Arg Ala Met Tyr Arg Phe Met 
        275                 280                 285             


Gly Leu Tyr Glu Phe Gln Lys Ala Asp Leu Lys Asp Gly Ala Val Trp 
    290                 295                 300                 


Lys Arg Val Lys Cys Glu Val Gln Thr Tyr Ser Pro Lys Glu Thr Lys 
305                 310                 315                 320 


Cys 
    


<210>  8
<211>  285
<212>  PRT
<213>  Pseudoalteromonas atlantica

<400>  8

Met Asp Lys Lys Glu Tyr Ile Ile Arg Gln Leu Gly Arg Thr Lys Asn 
1               5                   10                  15      


Lys Lys Tyr Glu Ala Tyr Val Val Thr Arg Ile Ile His Leu Leu Asn 
            20                  25                  30          


Asp Phe Ser Ile Lys Phe Ile Thr Gln Gln Tyr Val Thr Arg Pro Lys 
        35                  40                  45              


Gly Arg Ala Leu Thr Asp Leu Tyr Phe Pro Gln Phe Ala Phe His Ile 
    50                  55                  60                  


Glu Val Asp Glu Gly Gln His Phe Asn Gln Ala Asn Ile Glu Ala Asp 
65                  70                  75                  80  


Lys Ile Arg Glu Ala Asp Ile Ile Asn Ala Thr Gly His Glu Ile Leu 
                85                  90                  95      


Arg Ile Asp Val Thr Lys Ser Phe Asp Asp Ile Asn Thr Gln Ile Asp 
            100                 105                 110         


Ala Ala Val Asn Lys Ile Lys Ser Met Arg Gln Glu Ile Ser Phe Ile 
        115                 120                 125             


Pro Trp Asp Ile Asp Ser Glu Phe Asp Ser Ala Thr Tyr Ile Lys Arg 
    130                 135                 140                 


Gly Tyr Ile Asp Ile Lys Asp Asn Val Ala Phe Lys Thr Ile Lys Asp 
145                 150                 155                 160 


Ala Cys Asn Cys Phe Gly His Asn Tyr Thr Gly Tyr Gln Arg Ala Gly 
                165                 170                 175     


Ala Ala His Pro Asp His Tyr Ile Met Leu Trp Phe Pro Lys Leu Phe 
            180                 185                 190         


Pro Asn Gly Glu Trp Asp Asn Gln Ile Ser Ser Asp Glu Glu Val Ile 
        195                 200                 205             


Thr Glu Arg Asn Glu Asp Asp Lys Lys Ala Lys Gln His Val Ser Ser 
    210                 215                 220                 


His Val Asn Asn Lys Glu Lys His Lys His Gln Arg Ile Val Phe Ala 
225                 230                 235                 240 


Lys Val Arg Gly Asn Leu Gly Asp Val Leu Tyr Arg Phe Arg Gly Gln 
                245                 250                 255     


Tyr Gln Leu Asp Val Lys Asp Ser Asn Glu Lys Thr Gly Leu Ile Trp 
            260                 265                 270         


Arg Arg Ile Lys Thr Arg Val Lys Thr Tyr Glu Gln Asn 
        275                 280                 285 


<210>  9
<211>  289
<212>  PRT
<213>  Yersinia kristensenii

<400>  9

Met Ile Ser Gln Tyr Glu Tyr Val Val Arg Gln Leu Ala Arg Thr Lys 
1               5                   10                  15      


Asn Lys Lys His Glu Gln Tyr Val Val Thr Gly Ile Val His Lys Leu 
            20                  25                  30          


Asn Arg Asp Asp Ile Lys Phe Val Thr Gln Gln Tyr Val Lys Arg Glu 
        35                  40                  45              


Ser Gly Arg Ala Leu Thr Asp Leu Tyr Phe Pro Ala Ile Asn Leu His 
    50                  55                  60                  


Ile Glu Ile Asp Glu Pro Phe His Leu Lys Gln Ala Glu His Asp Asn 
65                  70                  75                  80  


Leu Arg Glu Ala Asp Ile Ile Asp Ala Thr Gly His Glu Val Ile Arg 
                85                  90                  95      


Ile Ser Val Asp Gly Ser Leu Arg Gln Met Asn Glu Arg Ile Asp Asp 
            100                 105                 110         


Cys Val Ala Ala Ile Lys Ser Lys Ile Ser Ala Leu Gly Asp Cys Phe 
        115                 120                 125             


Glu Pro Trp Asp Met Asp Lys Glu Leu Ser Ile Glu Pro His Ile Arg 
    130                 135                 140                 


Arg Gly Tyr Ile Asp Val Lys Asp Asn Val Ala Phe Arg Arg Ile Thr 
145                 150                 155                 160 


Asp Ala Cys Asn Cys Phe Gly His Asn Tyr Lys Phe Leu Gln Lys Ala 
                165                 170                 175     


Gly Ala Lys His Pro Tyr His Asp Asp Ile Leu Ile Trp Leu Pro Lys 
            180                 185                 190         


Leu Phe Asp Asn Glu His Trp Ser Asn Gln Ile Ser Asn Asp Glu Asn 
        195                 200                 205             


Val Ile Thr Glu Ile Pro Lys Ser Glu Asp Ala Gln Ala Ala His Phe 
    210                 215                 220                 


Asp Lys Trp Met Ala Glu Thr Arg Asn Lys Arg Leu Val Phe Ala Lys 
225                 230                 235                 240 


Ala Lys Asp Asn Leu Gly Met Thr Leu Tyr Arg Phe Lys Gly Leu Tyr 
                245                 250                 255     


Glu Leu Asn Pro Lys Lys Ser Asn Arg Thr Ile Gly Leu Tyr Trp Gln 
            260                 265                 270         


Arg Ile Ser Thr Arg Val Lys Thr Tyr Pro Ser Pro Ala Arg Asn Pro 
        275                 280                 285             


Asp 
    


<210>  10
<211>  283
<212>  PRT
<213>  Shewanella pealeana

<400>  10

Met Lys Thr Leu His Met Thr Arg Gln Leu Gln Arg Cys Lys Asn Lys 
1               5                   10                  15      


Arg Phe Glu Leu Tyr Ala Ile Thr Arg Ile Ile His Lys Val Asp Asp 
            20                  25                  30          


Leu Asp Ile Lys Phe Ile Thr Gln Gln Tyr Val Ala Arg Pro Asp Gly 
        35                  40                  45              


Phe Ala Leu Thr Asp Leu Tyr Leu Pro Gln Leu Lys Leu His Ile Glu 
    50                  55                  60                  


Ile Asp Glu Gly Phe His Lys Gln Gln Val Asp Ala Asp Lys Val Arg 
65                  70                  75                  80  


Glu Leu Asp Ile Ile Thr Ala Thr Asp His Gln Val Lys Arg Ile Asp 
                85                  90                  95      


Ala Ser Val Ala Ile Glu Gln Ile Asn Leu Gln Val Asp Gln Ile Val 
            100                 105                 110         


Ala Glu Ile Leu Gln Ser Val Glu Val Gln Lys Ala Ala Gly Asn Phe 
        115                 120                 125             


Gln Ala Trp Asp Pro Glu Thr Glu His Ser Val Ser Tyr Leu Gln Ser 
    130                 135                 140                 


Arg Gly Val Ile Arg Ala Ser Glu Asn Val Ala Leu Arg Thr Ser Ala 
145                 150                 155                 160 


Glu Val Cys Asn Leu Leu Gly His Asn Tyr Lys Gly Trp Gln Arg Ser 
                165                 170                 175     


Ser Ala Ser Val Pro His Tyr Pro Asn Ile Arg Leu Trp Phe Pro Lys 
            180                 185                 190         


Leu Tyr Pro Asn Glu Gln Trp Phe Asn His Ile Ser Tyr Asp Gly Cys 
        195                 200                 205             


Glu Ile His Glu Tyr Cys Ile Glu Ser Glu Thr Lys Lys Arg Gln Phe 
    210                 215                 220                 


Ile Asp Lys Asn Leu Ser Glu Asn Ile Gln Gln Met Val Phe Ala Arg 
225                 230                 235                 240 


Val Lys Asp Glu Leu Gly Gln Thr Met Tyr Arg Phe Lys Gly Leu Phe 
                245                 250                 255     


Ile Leu Asp Arg Asp Lys Thr Cys His Glu Ser Gly Val Tyr Trp Lys 
            260                 265                 270         


Arg Val Ala Thr Glu Phe Glu Leu Gly Leu Thr 
        275                 280             


<210>  11
<211>  296
<212>  PRT
<213>  Environmental sample, Newport Harbor, Rhode Island

<400>  11

Met Ser Lys Phe Thr Lys Glu Thr Tyr Val Thr Arg Asn Phe Gln Lys 
1               5                   10                  15      


Ile Ser Gly Lys Arg Trp Glu Leu Tyr Val Ile Thr Arg Val Ile His 
            20                  25                  30          


Leu Leu Asn Asp Pro Asp Ile Glu Tyr Val Cys Gln Gln Tyr Ile Asn 
        35                  40                  45              


Pro Pro Gln Asn Lys Asp Tyr Tyr Leu Ala Asp Leu Ala Phe Pro Ser 
    50                  55                  60                  


Leu Lys Leu Tyr Leu Glu Ile Asp Glu Gly Gln His Gly Ser Glu Met 
65                  70                  75                  80  


His Gln Thr Ser Asp Leu Lys Arg Asp Ala Glu Ile Leu Glu Ala Thr 
                85                  90                  95      


Asp Trp Thr Cys Lys Arg Ile Pro Val Phe Val Lys Lys Gly Ser Ser 
            100                 105                 110         


Lys Ile Asp Lys Ser Leu Glu Ala Leu Asn Lys Glu Ile Asp Asp Phe 
        115                 120                 125             


Val Ser Tyr Val Glu Gln Lys Lys Gln Lys Met Val Ser Ala Gly His 
    130                 135                 140                 


Lys Ile Ser Trp Asn Tyr Glu Gln Lys Phe Ser Pro Asp Thr Phe Ile 
145                 150                 155                 160 


Ala Lys Glu Lys Ile Lys Val Ser Asp Asn Val Ala Leu Leu Asn His 
                165                 170                 175     


Arg Asp Val Leu Arg Leu Phe Gly Tyr Lys Lys Gly His Tyr Gln Arg 
            180                 185                 190         


Ala Val Trp Thr Ile Lys Lys Thr Asn Gln Met Val Trp Phe Pro Lys 
        195                 200                 205             


Leu Tyr Pro Asn Ser Asp Trp Val Asn Ser Phe Asp Asp Lys Ser Gly 
    210                 215                 220                 


Tyr Ile His Gln Phe Arg Lys Asp Asn Gln Pro His Pro Met Pro Lys 
225                 230                 235                 240 


Glu Gly Asp Pro Asp Arg Ile Val Phe Ala His Gln Lys Asn Ile Phe 
                245                 250                 255     


Gly Gln Thr Val Tyr Lys Phe Phe Gly Ile Phe Arg Ala Asp Leu Asn 
            260                 265                 270         


Lys Thr Asp Pro Val His His Tyr Phe Lys Arg Ile Asn Thr Cys Leu 
        275                 280                 285             


Asp Leu Ser Arg Tyr Ser Ala Asn 
    290                 295     


<210>  12
<211>  293
<212>  PRT
<213>  Proteus penneri

<400>  12

Met Ser Lys Thr Asp Tyr Ile Leu Arg Ser Leu Ser Lys Ile Thr Lys 
1               5                   10                  15      


Lys Arg Trp Glu His Tyr Val Ile Asn Arg Ile Phe His Lys Leu Asp 
            20                  25                  30          


Asp Pro Glu Ile Glu Phe Val Cys Gln Gln Cys Ile Arg Lys Ala Asn 
        35                  40                  45              


Ser Pro Asp Lys Ile Tyr Leu Ala Asp Leu Phe Phe Pro Gln Leu Ala 
    50                  55                  60                  


Leu Tyr Leu Glu Ile Asp Glu Glu His His Asp Ser Asp Glu Ala Lys 
65                  70                  75                  80  


Lys Lys Asp Ala Lys Arg Arg Leu Asp Ile Ile Glu Ala Thr Gly Phe 
                85                  90                  95      


Ile Glu Lys Arg Ile Pro Ala Ser Asn Val Thr Ile Glu Gln Leu Asn 
            100                 105                 110         


Thr Ser Ile Asp Glu Phe Val Lys Leu Leu Ile Asp Thr Lys Glu Lys 
        115                 120                 125             


Gln Lys Ala Gln Lys Lys Phe Ile Pro Trp Asp Tyr Ser Ala Gln Tyr 
    130                 135                 140                 


Thr Ala Lys Arg His Ile Asp Ala Gly Phe Ile Glu Val Gly Pro His 
145                 150                 155                 160 


Ala Ile Phe Arg Tyr His Arg Asp Ala Leu Glu Cys Phe Gly Tyr Ile 
                165                 170                 175     


Asn Lys Gly His His Gln Ser Gly Ser Trp Lys Leu Pro Glu Asn Ile 
            180                 185                 190         


Val Arg Glu Ile Gly Leu Ser Gly Arg Ile Met Val Trp Phe Pro Arg 
        195                 200                 205             


Leu Tyr Asn Ala Gly Val Trp Asn Asn Glu Leu Ser Pro Asp Gly Glu 
    210                 215                 220                 


Trp Ile Thr Glu Glu Ser Leu Glu Val Asp Asn Asn Tyr Ile Glu Asp 
225                 230                 235                 240 


Trp Asp Tyr Arg Ile Val Met Ala His Ser Arg Asp Glu Leu Asn Arg 
                245                 250                 255     


Val Leu Tyr Arg Phe Leu Gly Val Phe Gln Ile Asp Lys Asn Lys Ser 
            260                 265                 270         


Val Glu Gly Lys Asn Ile Phe Lys Arg Ile Asn Thr Lys Val Lys Val 
        275                 280                 285             


Phe Asn Ser Tyr Asn 
    290             


<210>  13
<211>  293
<212>  PRT
<213>  Proteus vulgaris

<400>  13

Met Ser Lys Thr Asp Tyr Ile Leu Arg Ala Leu Ser Lys Ile Ser His 
1               5                   10                  15      


Lys Arg Trp Glu His Tyr Ile Ile Asn Arg Val Val His Thr Leu Asp 
            20                  25                  30          


Asp Pro Asp Ile Glu Phe Val Cys Gln Gln Cys Ile Arg Lys Glu Gly 
        35                  40                  45              


His Leu Gly Lys Ile Tyr Leu Ala Asp Leu Leu Phe Pro Gln Leu Asn 
    50                  55                  60                  


Leu Tyr Leu Glu Ile Asp Glu Ala His His Asp Ser Asn Asp Ala Arg 
65                  70                  75                  80  


Lys Ala Asp Ala Val Arg Arg Leu Asp Ile Val Glu Ala Thr Gly Phe 
                85                  90                  95      


Gln Glu Glu Arg Ile Pro Ala Ser Asn Ile Thr Leu Ser Glu Val Asn 
            100                 105                 110         


Lys Leu Val Asp Glu Phe Val Arg Leu Val Lys Asp Lys Lys Glu Glu 
        115                 120                 125             


Leu Glu Asn Gln Gly Leu Phe Phe Arg Trp Asp Tyr Asp Glu Arg Tyr 
    130                 135                 140                 


Ser Ala Lys Lys His Ile Asn Thr Gly Tyr Met Ala Val Gly Pro Asn 
145                 150                 155                 160 


Ser Val Phe Arg Tyr His Arg Asp Ala Leu Gln Cys Phe Gly Tyr Arg 
                165                 170                 175     


Arg Glu Gly His His Gln Ser Gly Gly Trp Ala Leu Pro Ala Glu Val 
            180                 185                 190         


Ala Gln Ser Ile Gly Leu Thr Gly Arg Val Met Val Trp Phe Pro Arg 
        195                 200                 205             


Leu Tyr Glu Ala Gly Glu Trp Lys Asn Ala Leu Ser Ala Asp Gly Asn 
    210                 215                 220                 


Lys Ile Thr Glu Gln Ser Leu Asn Ala Thr Arg Asn Tyr Gln Glu Thr 
225                 230                 235                 240 


Trp Asp Tyr Arg Ile Val Met Ala His Ser Arg Asp Glu Leu Asn Arg 
                245                 250                 255     


Thr Leu Tyr Arg Phe Leu Gly Val Phe Ala Ile Asp Val Asp Lys Ser 
            260                 265                 270         


Ser Asp Glu Val Lys Val Phe Ser Arg Val Tyr Ser Arg Val Asn Val 
        275                 280                 285             


Tyr Arg Ser Gln Asn 
    290             


<210>  14
<211>  102
<212>  PRT
<213>  artificial

<220>
<223>  consensus sequence in N-terminal domain


<220>
<221>  MISC_FEATURE
<222>  (2)..(8)
<223>  X =any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(32)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(50)
<223>  X may be repeated as few as 11 times and as much as 16 times

<220>
<221>  MISC_FEATURE
<222>  (53)..(54)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(61)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (66)..(67)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (69)..(94)
<223>  X may be repeated as few as 6 times and as much as 26 times

<220>
<221>  MISC_FEATURE
<222>  (96)..(97)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(101)
<223>  X=any amino acid

<400>  14

Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Glu Xaa Tyr Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Asp Leu Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Asp 
    50                  55                  60                  


Glu Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa 
                85                  90                  95      


Xaa Arg Xaa Xaa Xaa Ile 
            100         


<210>  15
<211>  79
<212>  PRT
<213>  artificial

<220>
<223>  consensus sequence in the N-terminal


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(43)
<223>  X=any amino acid; X may be repeated as few as 30 times and as 
       much as 40 times

<220>
<221>  MISC_FEATURE
<222>  (45)..(57)
<223>  X=any amino acid, X may be repeated as few as 12 times and as 
       much as 13 times

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (61)..(78)
<223>  X=any amino acid, X may be repeated as few as 16 times and as 
       much as 18 times

<400>  15

Trp Xaa Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Gly Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg 
65                  70                  75                  


<210>  16
<211>  102
<212>  PRT
<213>  artificial

<220>
<223>  consensus sequence in the N-terminal domain


<220>
<221>  MISC_FEATURE
<222>  (2)..(8)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(32)
<223>  X=any amino acid


<220>
<221>  MISC_FEATURE
<222>  (35)..(50)
<223>  X=any amino acid, X may be repeated as few as 11 times and as 
       much as 16 times

<220>
<221>  MISC_FEATURE
<222>  (53)..(54)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(61)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (66)..(67)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (69)..(94)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (96)..(97)
<223>  X=any amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(101)
<223>  X=any amino acid

<400>  16

Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Glu Xaa Tyr Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Asp Leu Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Asp 
    50                  55                  60                  


Glu Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa 
                85                  90                  95      


Xaa Arg Xaa Xaa Xaa Ile 
            100         


