                         SEQUENCE LISTING

<110>  De Los Santos, Teresa B.
       Zhu, James J.
       Koster, Marla J.
       Grubman, Marvin J.
       San Segundo, Fayna D.
 
<120>  Recombinant Live Attenuated Foot-and-Mouth Disease (FMD) Vaccine 
       Containing Mutations in the L Protein Coding Region

<130>  0026.10

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  37
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  1

Pro Glu Asn Leu Thr Leu Ala Ala Ile Lys Gln Leu Glu Glu Leu Thr 
1               5                   10                  15      


Gly Leu Glu Leu His Glu Gly Gly Pro Pro Ala Leu Val Ile Trp Asn 
            20                  25                  30          


Ile Lys His Leu Leu 
        35          


<210>  2
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  2

Ile Asp Lys Trp Lys Val Thr Glu Leu Lys Glu Glu Leu Lys Arg Arg 
1               5                   10                  15      


Arg Leu Thr Thr Arg Gly Leu Lys Glu Glu Leu Val Arg Arg Leu Asp 
            20                  25                  30          


Glu Ala Leu 
        35  


<210>  3
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  3

Leu Asn Asp Phe Ser Leu Thr Thr Leu Lys Asp Trp Leu Arg Ile Leu 
1               5                   10                  15      


Gly Gln Asn Thr Glu Gly Thr Lys Thr Glu Leu Ile Ala Arg Leu Gln 
            20                  25                  30          


Asp Ile Pro 
        35  


<210>  4
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  4

Leu Lys Lys Phe Arg Asn Ala Met Leu Lys Ser Ile Cys Glu Val Leu 
1               5                   10                  15      


Asp Leu Glu Arg Ser Gly Val Asn Ser Glu Leu Val Lys Arg Ile Leu 
            20                  25                  30          


Asn Phe Leu 
        35  


<210>  5
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  5

Glu Thr Gly Leu Ile Ile Pro Gln Leu Lys Asp Ile Leu Arg Val Phe 
1               5                   10                  15      


Gly Leu Arg Leu Ser Gly Thr Lys Ala Glu Leu Ile Thr Arg Ile Lys 
            20                  25                  30          


Gln Leu Ile 
        35  


<210>  6
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  6

Leu Gln Ala Leu Arg Val Thr Asp Leu Lys Ala Ala Leu Glu Gln Arg 
1               5                   10                  15      


Gly Leu Ala Lys Ser Gly Gln Lys Ser Ala Leu Val Lys Arg Leu Lys 
            20                  25                  30          


Gly Ala Leu 
        35  


<210>  7
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  7

Leu Ser Ser Leu Lys Val Thr Glu Leu Lys Glu Glu Leu Glu Asn Arg 
1               5                   10                  15      


Gln Leu Ser Thr Lys Gly Val Lys Ala Val Leu Gln Glu Arg Leu Arg 
            20                  25                  30          


Glu Ala Leu 
        35  


<210>  8
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  8

Val Met Ser Phe Arg Val Ser Asp Leu Gln Met Leu Leu Gly Phe Val 
1               5                   10                  15      


Gly Arg Ser Lys Ser Gly Leu Lys His Glu Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Gln Leu Val 
        35  


<210>  9
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  9

Leu Ser Glu Leu Arg Val Ile Asp Leu Arg Ala Glu Leu Lys Lys Arg 
1               5                   10                  15      


Asn Leu Asp Thr Gly Gly Asn Lys Ser Val Leu Met Glu Arg Leu Lys 
            20                  25                  30          


Lys Ala Val 
        35  


<210>  10
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  10

Val Met Ser Leu Arg Val Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala 
1               5                   10                  15      


Gly Arg Asn Lys His Gly Arg Lys His Glu Leu Leu Thr Lys Ala Leu 
            20                  25                  30          


His Leu Leu 
        35  


<210>  11
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  11

Tyr Ala Leu Leu Ser Glu Ser Lys Ile Arg Ser Lys Leu Ser Glu Met 
1               5                   10                  15      


Gly Leu Pro Thr Asp Gly His Lys Gln Leu Leu Gln Arg Arg His Ala 
            20                  25                  30          


Lys Trp Val 
        35  


<210>  12
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  12

Tyr Ser Leu Leu Lys Asp Thr Val Leu Arg Lys Lys Leu Lys Asp Leu 
1               5                   10                  15      


Gly Ile Pro Asn Trp Gly Pro Arg Ala Leu Leu Gln Arg Arg His Thr 
            20                  25                  30          


Glu Trp Leu 
        35  


<210>  13
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  13

Leu Gly Lys Leu Thr Val Pro Thr Leu Lys Asp Ile Cys Lys Ala His 
1               5                   10                  15      


Gly Leu Lys Ser Gly Pro Lys Lys Gln Glu Leu Leu Asp Ala Leu Ile 
            20                  25                  30          


Arg His Leu 
        35  


<210>  14
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  14

Val Leu Asn Met Thr Cys Asp Lys Leu Arg Lys Glu Leu Lys Lys Lys 
1               5                   10                  15      


Arg Ala Ser Thr Ala Gly Lys Lys Ser Glu Leu Gln Ser Arg Leu Leu 
            20                  25                  30          


Glu Phe Leu 
        35  


<210>  15
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  15

Tyr Ser Ile Val Arg Asp Thr Ala Leu Arg Lys Lys Leu Ser Glu Leu 
1               5                   10                  15      


Gly Leu Ser Thr His Gly Ser Arg Gln Leu Leu Glu Lys Arg His Lys 
            20                  25                  30          


Glu Trp Ile 
        35  


<210>  16
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  16

Ala Ser Lys Met Val Val Ser Glu Leu Lys Glu Glu Leu Glu Ala Gln 
1               5                   10                  15      


Gly Leu Pro Ile Asp Gly Thr Arg Asn Val Leu Tyr Gln Arg Val Gln 
            20                  25                  30          


Lys Ala Arg 
        35  


<210>  17
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  17

Val Lys Lys Leu Lys Val Ser Glu Leu Lys Glu Glu Leu Lys Lys Arg 
1               5                   10                  15      


Arg Leu Ser Asp Lys Gly Leu Lys Ala Asp Leu Met Glu Arg Leu Gln 
            20                  25                  30          


Ala Ala Leu 
        35  


<210>  18
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  18

Ile Lys Ala Leu Lys Val Ser Gln Leu Lys Asp Ile Leu Arg Asp Arg 
1               5                   10                  15      


Gly Leu Arg Val Ser Gly Lys Lys Ala Asp Leu Leu Asp Asn Leu Thr 
            20                  25                  30          


Asn Tyr Val 
        35  


<210>  19
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  19

Val Arg Arg Leu Lys Val Asn Glu Leu Arg Glu Glu Leu Gln Arg Arg 
1               5                   10                  15      


Gly Leu Asp Thr Arg Gly Leu Lys Thr Glu Leu Ala Glu Arg Leu Gln 
            20                  25                  30          


Ala Ala Leu 
        35  


<210>  20
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  20

Met Asp Thr Met Thr Ala Glu Gln Leu Lys Gln Ala Leu Met Lys Ile 
1               5                   10                  15      


Lys Val Ser Thr Gly Gly Asn Lys Lys Thr Leu Arg Lys Arg Val Ala 
            20                  25                  30          


Gln Tyr Tyr 
        35  


<210>  21
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  21

Met Ala Pro Gly Ala Ala Gln Glu Leu Gln Ala Lys Leu Ala Glu Ile 
1               5                   10                  15      


Gly Ala Pro Ile Gln Gly Asn Arg Glu Glu Leu Val Glu Arg Leu Gln 
            20                  25                  30          


Ser Tyr Thr 
        35  


<210>  22
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  22

Ile Thr Asp Leu Arg Val Ile Asp Leu Lys Ser Glu Leu Lys Arg Arg 
1               5                   10                  15      


Asn Leu Asp Ile Thr Gly Val Lys Thr Val Leu Ile Ser Arg Leu Lys 
            20                  25                  30          


Gln Ala Ile 
        35  


<210>  23
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  23

Phe Ser Ser Leu Ser Thr Gln Lys Ile Lys Ala Lys Leu Ser Asp Leu 
1               5                   10                  15      


Lys Leu Pro Thr Thr Gly Ser Arg Asn Glu Met Glu Ala Arg Tyr Leu 
            20                  25                  30          


His Tyr Tyr 
        35  


<210>  24
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  24

Leu Gly Lys Leu Thr Val Ser Ala Leu Lys Asp Thr Cys Arg His Tyr 
1               5                   10                  15      


Gly Leu Arg Ser Gly Gly Lys Lys Gln Glu Leu Ile Asp Ala Leu Thr 
            20                  25                  30          


Glu Tyr Phe 
        35  


<210>  25
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  25

Phe Thr Ser Met Thr Gln Ser Gln Ile Lys Gln Lys Leu Ser Ser Leu 
1               5                   10                  15      


Gly Leu Ser Thr Asn Gly Thr Arg Gln Asn Met Ile Lys Arg Tyr Asn 
            20                  25                  30          


His Tyr Glu 
        35  


<210>  26
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  26

Val Gln Met Leu Arg Val Val Glu Leu Gln Lys Ile Leu Ser Phe Leu 
1               5                   10                  15      


Asn Ile Ser Phe Ala Gly Arg Lys Thr Asp Leu Gln Ser Arg Ile Leu 
            20                  25                  30          


Ser Phe Leu 
        35  


<210>  27
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  27

Leu Ala Ser Leu Thr Val Ser Val Leu Arg Asp Phe Cys Lys Gln Glu 
1               5                   10                  15      


Gly Leu Arg Cys Pro Ser Lys Lys Ala Glu Ile Val Asp Cys Ile Lys 
            20                  25                  30          


Lys His Leu 
        35  


<210>  28
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  28

Tyr Asn Leu Leu Ser Asp Arg Asp Leu Lys Lys Lys Leu Lys Gln Tyr 
1               5                   10                  15      


Gly Leu Ser Val Pro Gly Asn Lys Gln Gln Leu Ile Lys Arg His Gln 
            20                  25                  30          


Glu Phe Val 
        35  


<210>  29
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  29

Tyr Ser Ser Leu Thr Val Val Gln Leu Lys Asp Leu Leu Thr Lys Arg 
1               5                   10                  15      


Asn Leu Ser Val Gly Gly Leu Lys Asn Glu Leu Val Gln Arg Leu Ile 
            20                  25                  30          


Lys Asp Asp 
        35  


<210>  30
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  30

Tyr Lys Ser Leu Lys Val Ala Glu Leu Arg Glu Lys Leu Ala Glu Lys 
1               5                   10                  15      


Gly Leu Ser Thr Ala Gly Asn Lys Ala Glu Leu Val Ser Arg Leu Thr 
            20                  25                  30          


Ala Ala Thr 
        35  


<210>  31
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  31

Phe Gln Lys Phe Thr Val Lys Val Leu Lys Glu Gln Cys Lys Ser Arg 
1               5                   10                  15      


Gly Leu Lys Leu Ser Gly Arg Lys Ser Asp Leu Leu Gln Arg Leu Ile 
            20                  25                  30          


Thr His Asp 
        35  


<210>  32
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  32

Ser Ala Arg Leu Arg Val Ala Asp Val Arg Ala Glu Leu Gln Arg Arg 
1               5                   10                  15      


Gly Leu Asp Val Ser Gly Thr Lys Pro Ala Leu Val Arg Arg Leu Asp 
            20                  25                  30          


Ala Ala Ile 
        35  


<210>  33
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  33

Ile Glu Ala Met Thr Val Gln Glu Leu Arg Ser Thr Leu Arg Lys Leu 
1               5                   10                  15      


Gly Val Pro Val Lys Gly Arg Lys Gln Glu Leu Ile Ser Thr Leu Arg 
            20                  25                  30          


Leu His Met 
        35  


<210>  34
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  34

Pro Lys Thr Met Lys Val Asn Asp Leu Arg Lys Glu Leu Glu Ser Arg 
1               5                   10                  15      


Ala Leu Ser Ser Lys Gly Leu Lys Ser Gln Leu Ile Ala Arg Leu Thr 
            20                  25                  30          


Lys Gln Leu 
        35  


<210>  35
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  35

Met Ala Thr Val Lys Leu Ser Phe Leu Gln His Ile Cys Lys Leu Thr 
1               5                   10                  15      


Gly Leu Ser Arg Ser Gly Arg Lys Asp Glu Leu Leu Arg Arg Ile Val 
            20                  25                  30          


Asp Ser Pro 
        35  


<210>  36
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  36

Met Glu Gln Leu Lys Val Leu Glu Leu Lys Gln Ile Cys Lys Ser Leu 
1               5                   10                  15      


Asp Leu Ser Ile Thr Gly Lys Lys Ala Val Leu Gln Asp Arg Ile Lys 
            20                  25                  30          


Gln Phe Leu 
        35  


<210>  37
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  37

Val Pro Leu Leu Pro Lys Asn Arg Leu Val Lys Glu Leu Gln Asp Arg 
1               5                   10                  15      


Gly Leu Asp Thr Ser Gly Val Gln Thr Val Leu Ala Asp Arg Leu Val 
            20                  25                  30          


Glu Phe Leu 
        35  


<210>  38
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  38

Leu Glu Gly Met Ser Tyr Arg Glu Leu Gln Gly Leu Ala Lys Ala Arg 
1               5                   10                  15      


Gly Val Ala Ala Asn Gly Gly Lys Lys Asp Val Ile Gln Arg Leu Leu 
            20                  25                  30          


Ser Ala Thr 
        35  


<210>  39
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  39

Ile Lys Lys Val Asp Asn Lys Gly Leu Arg Ser Ile Cys Glu Ile Leu 
1               5                   10                  15      


Thr Leu Asp Arg Lys Gly Ser Lys Asn Glu Thr Val Leu Arg Val Leu 
            20                  25                  30          


Lys Phe Leu 
        35  


<210>  40
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  40

Leu His Lys Leu Lys Leu Ala Glu Leu Lys Gln Glu Cys Leu Ala Arg 
1               5                   10                  15      


Gly Leu Glu Thr Lys Gly Ile Lys Gln Asp Leu Ile His Arg Leu Gln 
            20                  25                  30          


Ala Tyr Leu 
        35  


<210>  41
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  41

Phe Arg Gly Met Ile Val Lys Glu Leu Arg Glu Glu Ala Ile Lys Arg 
1               5                   10                  15      


Gly Leu Asp Thr Thr Gly Thr Lys Lys Asp Leu Leu Glu Arg Leu Cys 
            20                  25                  30          


Asn Asp Ala 
        35  


<210>  42
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  42

Met Glu Leu Leu Lys Val Ser Glu Leu Lys Asp Ile Cys Arg Ser Val 
1               5                   10                  15      


Ser Phe Pro Val Ser Gly Arg Lys Ala Val Leu Gln Asp Leu Ile Arg 
            20                  25                  30          


Asn Phe Leu 
        35  


<210>  43
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  43

Ala Asn Lys Leu Lys Val Asp Glu Leu Arg Leu Lys Leu Ala Glu Arg 
1               5                   10                  15      


Gly Leu Ser Thr Thr Gly Val Lys Ala Val Leu Val Glu Arg Leu Glu 
            20                  25                  30          


Glu Ala Ile 
        35  


<210>  44
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  44

Pro Lys Ser Met Lys Val Ala Glu Leu Arg Val Glu Leu Glu Leu Arg 
1               5                   10                  15      


Gly Leu Glu Thr Lys Gly Ile Lys Thr Leu Leu Val Gln Arg Leu Gln 
            20                  25                  30          


Thr Ala Leu 
        35  


<210>  45
<211>  34
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  45

Asx Pro Pro Leu Pro Leu Ser Cys Leu Pro Asx Leu Cys Pro Asx Gly 
1               5                   10                  15      


Leu Ser Ser Ser Gly Pro Lys Ser Pro Leu Leu Pro Arg Leu Pro Pro 
            20                  25                  30          


Asx Leu 
        


<210>  46
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  46
ctcacactag cagccgccaa acagctggag gaactcacag gg                          42


<210>  47
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  47
ccctgtgagt tcctccagct gtttggcggc tgctagtgtg ag                          42


<210>  48
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  48
ctcacactag cagccatcaa acaggcggag gaactcacag gg                          42


<210>  49
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  49
ccctgtgagt tcctccgcct gtttgatggc tgctagtgtg ag                          42


<210>  50
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  50
ctcacactag cagccgccaa acaggcggag gaactcacag gg                          42


<210>  51
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized

<400>  51
ccctgtgagt tcctccgcct gtttggcggc tgctagtgtg ag                          42


