                         SEQUENCE LISTING

<110>  Butamax(TM) Advanced Biofuels, LLC
 
<120>  Alcohol Dehydrogenases (ADH) Useful for Fermentive Production of 
       Lower Alkyl Alcohols

<130>  CL4808

<150>  US 61/290,636
<151>  2009-12-29

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  1128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Horse-liver ADH

<400>  1
atgtcaacag ccggtaaagt tattaagtgt aaagcggcag ttttgtggga agagaaaaag       60

ccgtttagca tagaagaagt agaagtagcg ccaccaaaag cacacgaggt tagaatcaag      120

atggttgcca ccggaatctg tagatccgac gaccatgtgg tgagtggcac tctagttact      180

cctttgccag taatcgcggg acacgaggct gccggaatcg ttgaatccat aggtgaaggt      240

gttaccactg ttcgtcctgg tgataaagtg atcccactgt tcactcctca atgtggtaag      300

tgtagagtct gcaaacatcc tgagggtaat ttctgcctta aaaatgattt gtctatgcct      360

agaggtacta tgcaggatgg tacaagcaga tttacatgca gagggaaacc tatacaccat      420

ttccttggta cttctacatt ttcccaatac acagtggtgg acgagatatc tgtcgctaaa      480

atcgatgcag cttcaccact ggaaaaagtt tgcttgatag ggtgcggatt ttccaccggt      540

tacggttccg cagttaaagt tgcaaaggtt acacagggtt cgacttgtgc agtattcggt      600

ttaggaggag taggactaag cgttattatg gggtgtaaag ctgcaggcgc agcgaggatt      660

ataggtgtag acatcaataa ggacaaattt gcaaaagcta aggaggtcgg ggctactgaa      720

tgtgttaacc ctcaagatta taagaaacca atacaagaag tccttactga aatgtcaaac      780

ggtggagttg atttctcttt tgaagttata ggccgtcttg atactatggt aactgcgttg      840

tcctgctgtc aagaggcata tggagtcagt gtgatcgtag gtgttcctcc tgattcacaa      900

aatttgtcga tgaatcctat gctgttgcta agcggtcgta catggaaggg agctatattt      960

ggcggtttta agagcaagga tagtgttcca aaacttgttg ccgactttat ggcgaagaag     1020

tttgctcttg atcctttaat tacacatgta ttgccattcg agaaaatcaa tgaagggttt     1080

gatttgttaa gaagtggtga atctattcgt acaattttaa ctttttga                  1128


<210>  2
<211>  1083
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  2
atgtcttatc ctgagaaatt tgaaggtatc gctattcaat cacacgaaga ttggaaaaac       60

ccaaagaaga caaagtatga cccaaaacca ttttacgatc atgacattga cattaagatc      120

gaagcatgtg gtgtctgcgg tagtgatatt cattgtgcag ctggtcattg gggcaatatg      180

aagatgccgc tagtcgttgg tcatgaaatc gttggtaaag ttgtcaagct agggcccaag      240

tcaaacagtg ggttgaaagt cggtcaacgt gttggtgtag gtgctcaagt cttttcatgc      300

ttggaatgtg accgttgtaa gaatgataat gaaccatact gcaccaagtt tgttaccaca      360

tacagtcagc cttatgaaga cggctatgtg tcgcagggtg gctatgcaaa ctacgtcaga      420

gttcatgaac attttgtggt gcctatccca gagaatattc catcacattt ggctgctcca      480

ctattatgtg gtggtttgac tgtgtactct ccattggttc gtaacggttg cggtccaggt      540

aaaaaagttg gtatagttgg tcttggtggt atcggcagta tgggtacatt gatttccaaa      600

gccatggggg cagagacgta tgttatttct cgttcttcga gaaaaagaga agatgcaatg      660

aagatgggcg ccgatcacta cattgctaca ttagaagaag gtgattgggg tgaaaagtac      720

tttgacacct tcgacctgat tgtagtctgt gcttcctccc ttaccgacat tgacttcaac      780

attatgccaa aggctatgaa ggttggtggt agaattgtct caatctctat accagaacaa      840

cacgaaatgt tatcgctaaa gccatatggc ttaaaggctg tctccatttc ttacagtgct      900

ttaggttcca tcaaagaatt gaaccaactc ttgaaattag tctctgaaaa agatatcaaa      960

atttgggtgg aaacattacc tgttggtgaa gccggcgtcc atgaagcctt cgaaaggatg     1020

gaaaagggtg acgttagata tagatttacc ttagtcggct acgacaaaga attttcagac     1080

tag                                                                   1083


<210>  3
<211>  1086
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  3
atgctttacc cagaaaaatt tcagggcatc ggtatttcca acgcaaagga ttggaagcat       60

cctaaattag tgagttttga cccaaaaccc tttggcgatc atgacgttga tgttgaaatt      120

gaagcctgtg gtatctgcgg atctgatttt catatagccg ttggtaattg gggtccagtc      180

ccagaaaatc aaatccttgg acatgaaata attggccgcg tggtgaaggt tggatccaag      240

tgccacactg gggtaaaaat cggtgaccgt gttggtgttg gtgcccaagc cttggcgtgt      300

tttgagtgtg aacgttgcaa aagtgacaac gagcaatact gtaccaatga ccacgttttg      360

actatgtgga ctccttacaa ggacggctac atttcacaag gaggctttgc ctcccacgtg      420

aggcttcatg aacactttgc tattcaaata ccagaaaata ttccaagtcc gctagccgct      480

ccattattgt gtggtggtat tacagttttc tctccactac taagaaatgg ctgtggtcca      540

ggtaagaggg taggtattgt tggcatcggt ggtattgggc atatggggat tctgttggct      600

aaagctatgg gagccgaggt ttatgcgttt tcgcgaggcc actccaagcg ggaggattct      660

atgaaactcg gtgctgatca ctatattgct atgttggagg ataaaggctg gacagaacaa      720

tactctaacg ctttggacct tcttgtcgtt tgctcatcat ctttgtcgaa agttaatttt      780

gacagtatcg ttaagattat gaagattgga ggctccatcg tttcaattgc tgctcctgaa      840

gttaatgaaa agcttgtttt aaaaccgttg ggcctaatgg gagtatcaat ctcaagcagt      900

gctatcggat ctaggaagga aatcgaacaa ctattgaaat tagtttccga aaagaatgtc      960

aaaatatggg tggaaaaact tccgatcagc gaagaaggcg tcagccatgc ctttacaagg     1020

atggaaagcg gagacgtcaa atacagattt actttggtcg attatgataa gaaattccat     1080

aaatag                                                                1086


<210>  4
<211>  1170
<212>  DNA
<213>  Clostridium acetobutylicum

<400>  4
atgctaagtt ttgattattc aataccaact aaagtttttt ttggaaaagg aaaaatagac       60

gtaattggag aagaaattaa gaaatatggc tcaagagtgc ttatagttta tggcggagga      120

agtataaaaa ggaacggtat atatgataga gcaacagcta tattaaaaga aaacaatata      180

gctttctatg aactttcagg agtagagcca aatcctagga taacaacagt aaaaaaaggc      240

atagaaatat gtagagaaaa taatgtggat ttagtattag caataggggg aggaagtgca      300

atagactgtt ctaaggtaat tgcagctgga gtttattatg atggcgatac atgggacatg      360

gttaaagatc catctaaaat aactaaagtt cttccaattg caagtatact tactctttca      420

gcaacagggt ctgaaatgga tcaaattgca gtaatttcaa atatggagac taatgaaaag      480

cttggagtag gacatgatga tatgagacct aaattttcag tgttagatcc tacatatact      540

tttacagtac ctaaaaatca aacagcagcg ggaacagctg acattatgag tcacaccttt      600

gaatcttact ttagtggtgt tgaaggtgct tatgtgcagg acggtatacg agaagcaatc      660

ttaagaacat gtataaagta tggaaaaata gcaatggaga agactgatga ttacgaggct      720

agagctaatt tgatgtgggc ttcaagttta gctataaatg gtctattatc acttggtaag      780

gatagaaaat ggagttgtca tcctatggaa cacgagttaa gtgcatatta tgatataaca      840

catggtgtag gacttgcaat tttaacacct aattggatgg aatatattct aaatgacgat      900

acacttcata aatttgtttc ttatggaata aatgtttggg gaatagacaa gaacaaagat      960

aactatgaaa tagcacgaga ggctattaaa aatacgagag aatactttaa ttcattgggt     1020

attccttcaa agcttagaga agttggaata ggaaaagata aactagaact aatggcaaag     1080

caagctgtta gaaattctgg aggaacaata ggaagtttaa gaccaataaa tgcagaggat     1140

gttcttgaga tatttaaaaa atcttattaa                                      1170


<210>  5
<211>  1173
<212>  DNA
<213>  Clostridium acetobutylicum

<400>  5
atggttgatt tcgaatattc aataccaact agaatttttt tcggtaaaga taagataaat       60

gtacttggaa gagagcttaa aaaatatggt tctaaagtgc ttatagttta tggtggagga      120

agtataaaga gaaatggaat atatgataaa gctgtaagta tacttgaaaa aaacagtatt      180

aaattttatg aacttgcagg agtagagcca aatccaagag taactacagt tgaaaaagga      240

gttaaaatat gtagagaaaa tggagttgaa gtagtactag ctataggtgg aggaagtgca      300

atagattgcg caaaggttat agcagcagca tgtgaatatg atggaaatcc atgggatatt      360

gtgttagatg gctcaaaaat aaaaagggtg cttcctatag ctagtatatt aaccattgct      420

gcaacaggat cagaaatgga tacgtgggca gtaataaata atatggatac aaacgaaaaa      480

ctaattgcgg cacatccaga tatggctcct aagttttcta tattagatcc aacgtatacg      540

tataccgtac ctaccaatca aacagcagca ggaacagctg atattatgag tcatatattt      600

gaggtgtatt ttagtaatac aaaaacagca tatttgcagg atagaatggc agaagcgtta      660

ttaagaactt gtattaaata tggaggaata gctcttgaga agccggatga ttatgaggca      720

agagccaatc taatgtgggc ttcaagtctt gcgataaatg gacttttaac atatggtaaa      780

gacactaatt ggagtgtaca cttaatggaa catgaattaa gtgcttatta cgacataaca      840

cacggcgtag ggcttgcaat tttaacacct aattggatgg agtatatttt aaataatgat      900

acagtgtaca agtttgttga atatggtgta aatgtttggg gaatagacaa agaaaaaaat      960

cactatgaca tagcacatca agcaatacaa aaaacaagag attactttgt aaatgtacta     1020

ggtttaccat ctagactgag agatgttgga attgaagaag aaaaattgga cataatggca     1080

aaggaatcag taaagcttac aggaggaacc ataggaaacc taagaccagt aaacgcctcc     1140

gaagtcctac aaatattcaa aaaatctgtg taa                                  1173


<210>  6
<211>  1047
<212>  DNA
<213>  Achromobacter xylosoxidans

<400>  6
atgaaagctc tggtttatca cggtgaccac aagatctcgc ttgaagacaa gcccaagccc       60

acccttcaaa agcccacgga tgtagtagta cgggttttga agaccacgat ctgcggcacg      120

gatctcggca tctacaaagg caagaatcca gaggtcgccg acgggcgcat cctgggccat      180

gaaggggtag gcgtcatcga ggaagtgggc gagagtgtca cgcagttcaa gaaaggcgac      240

aaggtcctga tttcctgcgt cacttcttgc ggctcgtgcg actactgcaa gaagcagctt      300

tactcccatt gccgcgacgg cgggtggatc ctgggttaca tgatcgatgg cgtgcaggcc      360

gaatacgtcc gcatcccgca tgccgacaac agcctctaca agatccccca gacaattgac      420

gacgaaatcg ccgtcctgct gagcgacatc ctgcccaccg gccacgaaat cggcgtccag      480

tatgggaatg tccagccggg cgatgcggtg gctattgtcg gcgcgggccc cgtcggcatg      540

tccgtactgt tgaccgccca gttctactcc ccctcgacca tcatcgtgat cgacatggac      600

gagaatcgcc tccagctcgc caaggagctc ggggcaacgc acaccatcaa ctccggcacg      660

gagaacgttg tcgaagccgt gcataggatt gcggcagagg gagtcgatgt tgcgatcgag      720

gcggtgggca taccggcgac ttgggacatc tgccaggaga tcgtcaagcc cggcgcgcac      780

atcgccaacg tcggcgtgca tggcgtcaag gttgacttcg agattcagaa gctctggatc      840

aagaacctga cgatcaccac gggactggtg aacacgaaca cgacgcccat gctgatgaag      900

gtcgcctcga ccgacaagct tccgttgaag aagatgatta cccatcgctt cgagctggcc      960

gagatcgagc acgcctatca ggtattcctc aatggcgcca aggagaaggc gatgaagatc     1020

atcctctcga acgcaggcgc tgcctga                                         1047


<210>  7
<211>  981
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Bos taurus ARD

<400>  7
atggcggcga gctgcatttt gctgcacacc ggtcaaaaga tgccgctgat cggtctgggc       60

acctggaaat ctgacccagg tcaagtgaag gcggcaatta agtatgcgct gagcgtcggt      120

tatcgtcaca ttgactgcgc ggcaatctac ggcaatgaaa ccgagattgg cgaggcgttg      180

aaagagaacg tcggtccggg taagctggtc ccgcgtgaag aactgtttgt cacgagcaag      240

ctgtggaata ccaagcacca cccggaggac gtggaaccgg ctctgcgcaa aaccctggcc      300

gatctgcagt tggagtactt ggatctgtat ttgatgcact ggccgtatgc gtttgaacgc      360

ggtgactctc cgttcccgaa gaacgccgac ggcaccatcc gttacgacag cactcattat      420

aaagaaacct ggcgtgcgct ggaggcgctg gttgcaaaag gtctggtgcg tgccctgggt      480

ttgagcaatt ttaattctcg tcagatcgac gatgttctga gcgtggcctc tgtgcgtccg      540

gctgtgttgc aggtcgagtg tcacccttat ctggcgcaaa acgagctgat cgctcattgt      600

caagcgcgta atctggaagt gaccgcgtac tccccgctgg gtagcagcga ccgcgcctgg      660

cgtgatccgg aagaacctgt tctgctgaaa gaaccggtcg tgctggcgct ggctgaaaag      720

cacggtcgca gcccagcgca gatcttgctg cgttggcaag ttcagcgcaa agtttcttgc      780

atcccgaaat ctgtcacgcc gagccgtatt ctggagaaca ttcaagtttt cgacttcacc      840

tttagcccgg aagaaatgaa gcagctggac gccctgaaca agaatctgcg ttttattgtg      900

ccgatgttga ccgtggacgg caagcgcgtt ccgcgtgacg cgggtcaccc gttgtatcca      960

tttaacgatc cgtactaatg a                                                981


<210>  8
<211>  1125
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Rana perezi ADH8

<400>  8
atgtgcaccg ccggtaaaga tattacgtgt aaagcggcgg tcgcttggga gccgcataaa       60

ccgctgtccc tggaaacgat cacggttgca cctccaaaag cgcatgaggt gcgtattaaa      120

atcctggcgt ctggcatctg cggtagcgac agcagcgttc tgaaagagat catcccgagc      180

aagttcccgg tgattctggg tcatgaggcg gtgggcgtgg ttgagagcat cggtgcgggc      240

gttacgtgcg tgaaaccggg tgacaaggtg atcccgctgt tcgtgccgca atgtggttct      300

tgtcgcgcat gtaaaagcag caatagcaac ttctgtgaga agaatgatat gggcgcgaaa      360

acgggtttga tggcagacat gaccagccgt tttacgtgcc gtggtaagcc gatttataat      420

ctggtgggca ccagcacctt tacggagtac acggttgtgg ccgatatcgc ggtcgcaaag      480

atcgacccaa aagccccgct ggagagctgc ctgatcggtt gtggttttgc gacgggttat      540

ggtgcagcgg ttaacacggc caaagttacc cctggcagca cctgtgcagt gtttggcctg      600

ggcggtgttg gtttcagcgc tattgttggt tgtaaagcag ctggcgcatc ccgtattatt      660

ggcgttggta ctcataagga taagttcccg aaggcaatcg aactgggcgc aactgagtgc      720

ctgaatccga aggactatga caaaccgatc tatgaggtta tttgcgagaa aaccaatggc      780

ggtgtggatt acgcggtcga gtgtgcgggt cgtattgaaa ctatgatgaa cgcattgcag      840

tcgacctatt gcggttctgg cgttactgtt gtgttgggtc tggcgagccc gaacgagcgt      900

ctgccgctgg acccgttgtt gctgctgacg ggccgttccc tgaaaggtag cgtgtttggc      960

ggctttaaag gtgaagaagt tagccgtctg gtggatgact acatgaagaa gaagatcaat     1020

gttaatttcc tggtgagcac caaactgacg ctggatcaga tcaacaaagc gttcgaattg     1080

ctgagcagcg gtcaaggcgt tcgtagcatt atgatctact aatga                     1125


<210>  9
<211>  1059
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Clostridium beijerinckii 
       ADH

<400>  9
atgaaaggtt tcgctatgtt gggtattaat aagctgggtt ggattgagaa agagcgtccg       60

gtcgcaggca gctatgatgc aatcgttcgt ccgttggccg ttagcccgtg cacgagcgac      120

attcatacgg tgttcgaggg tgcactgggt gaccgtaaga acatgatcct gggtcatgag      180

gccgttggtg aagttgtcga agtcggtagc gaagtcaaag attttaaacc gggcgaccgt      240

gtcatcgttc catgcacgac gccagattgg cgtagcctgg aggtgcaggc aggtttccag      300

cagcatagca atggcatgct ggctggctgg aaattctcta atttcaagga tggtgtgttc      360

ggtgaatatt tccacgtgaa cgacgctgac atgaacctgg ctatcctgcc gaaggatatg      420

ccgctggaga acgcggtgat gatcacggat atgatgacta cgggttttca tggtgcggag      480

ctggcggaca tccaaatggg tagcagcgtg gtcgtcatcg gcatcggcgc tgtgggtctg      540

atgggcattg caggcgcaaa actgcgcggt gcgggtcgta tcatcggtgt gggtagccgc      600

cctatctgcg tggaggcggc gaagttttac ggtgcgactg acattctgaa ctataagaac      660

ggtcacattg ttgatcaagt gatgaagctg accaacggta aaggcgtgga tcgcgttatc      720

atggcgggtg gtggttcgga aacgctgagc caggcagtta gcatggtcaa gccgggtggc      780

attatcagca atattaatta ccacggtagc ggtgatgcgc tgctgatccc acgtgtcgag      840

tggggttgtg gtatggcaca caagaccatt aaaggcggtc tgtgcccggg tggtcgtttg      900

cgtgcggaaa tgctgcgtga tatggttgtc tataaccgtg ttgacctgag caagctggtg      960

acgcacgtct atcacggctt tgaccatatc gaagaggcgt tgctgctgat gaaggataaa     1020

ccgaaggacc tgattaaagc ggtcgtgatc ctgtaatga                            1059


<210>  10
<211>  1086
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Entamoeba histolytica 
       ADH1

<400>  10
atgaagggcc tggcgatgct gggtatcggt cgtattggtt ggattgaaaa gaaaatcccg       60

gagtgcggcc cactggatgc gttggtccgt ccgctggcgc tggccccgtg caccagcgac      120

acccacaccg tgtgggctgg cgcaatcggc gaccgtcacg acatgattct gggtcacgaa      180

gcggtcggtc agatcgtgaa ggtgggttcc ctggtgaagc gtctgaaggt tggcgataag      240

gtgatcgtcc cggcgattac tccggactgg ggtgaagaag aaagccaacg tggttacccg      300

atgcatagcg gtggtatgct gggcggctgg aagttctcca atttcaagga cggtgtcttt      360

tccgaggtgt tccacgtgaa cgaggcggat gctaacctgg cactgctgcc gcgtgatatt      420

aaacctgaag atgcggtcat gctgagcgac atggtgacca ccggctttca cggtgccgaa      480

ttggcgaata ttaaactggg tgataccgtg tgcgttattg gtatcggccc agtgggtctg      540

atgagcgtgg ctggtgcgaa tcacctgggt gccggtcgca tcttcgcggt tggtagccgc      600

aaacactgtt gtgatatcgc tctggaatac ggcgcgactg atattatcaa ttacaagaat      660

ggcgacattg tggagcaaat tttgaaggcg accgatggta aaggcgttga caaggttgtt      720

attgcaggtg gcgatgttca tacgtttgca caagcggtca agatgattaa accgggtagc      780

gatattggta acgtgaatta tctgggtgaa ggcgataaca ttgacattcc gcgtagcgaa      840

tggggtgtgg gcatgggtca taaacacatc cacggtggtt tgactcctgg cggtcgtgtc      900

cgcatggaaa agttggcttc gctgattagc accggcaaac tggacaccag caaactgatt      960

actcatcgtt tcgagggcct ggagaaggtg gaagatgcct tgatgctgat gaagaacaag     1020

ccggcagatc tgattaagcc ggttgtccgt attcactatg acgatgaaga tacgttgcac     1080

taatga                                                                1086


<210>  11
<211>  1047
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Beijerickia indica ADH

<400>  11
atgaaagcac tggtttaccg tggccctggc caaaagctgg tggaagaacg tcaaaagccg       60

gagctgaaag agccaggcga cgcgattgtg aaagtcacca aaacgaccat ctgtggtacg      120

gacttgcaca ttctgaaggg cgatgtggcg acgtgtaagc cgggtcgcgt gctgggtcac      180

gaaggtgtgg gtgttattga aagcgttggc agcggcgtta ccgcgttcca accgggtgat      240

cgcgtcctga tctcttgtat ttctagctgt ggcaagtgca gcttttgtcg ccgtggcatg      300

tttagccact gtaccactgg cggctggatt ctgggtaatg agattgacgg tacgcaggca      360

gagtacgttc gtgtcccgca tgccgacacc tctctgtatc gtattccagc gggtgcggac      420

gaagaggcgc tggtgatgct gagcgatatc ctgccgaccg gtttcgagtg tggtgtcctg      480

aatggtaagg ttgcgcctgg cagcagcgtt gcgatcgttg gcgcaggccc tgtcggtttg      540

gccgcattgc tgacggcgca gttctactct ccggcagaga ttatcatgat tgatctggac      600

gacaaccgcc tgggcctggc gaagcaattc ggcgcaacgc gtaccgttaa tagcaccggt      660

ggtaacgcag cagcagaggt caaggctctg acggagggcc tgggtgttga cacggctatt      720

gaggctgttg gcatcccggc caccttcgag ctgtgccaga acattgtggc tccgggtggc      780

actattgcga atgtcggcgt tcacggttcg aaagtggatc tgcatctgga atctctgtgg      840

agccataatg tgactatcac gacgcgtctg gtggacacgg caacgacgcc gatgctgctg      900

aaaaccgtgc aatctcataa actggacccg agccgtctga tcacccatcg ttttagcctg      960

gaccaaatcc tggatgcgta cgaaacgttt ggtcaggccg caagcaccca ggcgctgaag     1020

gttattatca gcatggaggc gtaatga                                         1047


<210>  12
<211>  1134
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Rattus norvegicus ADH1

<400>  12
atgagcaccg caggtaaagt gattaaatgc aaagcagcag ttctgtggga accgcataaa       60

ccgtttacca ttgaagatat tgaagttgca cctccgaaag cacatgaagt gcgcattaaa      120

atggttgcaa ccggtgtttg tcgttctgat gatcatgcag ttagcggtag cctgtttaca      180

ccgctgcctg cagttctggg tcatgaaggt gcaggtattg ttgaaagcat tggtgaaggt      240

gttacctgtg ttaaaccggg tgataaagtg attccgctgt tttctccgca gtgtggtaaa      300

tgtcgcattt gcaaacatcc ggaaagcaat ctgtgttgcc agaccaaaaa tctgacccag      360

ccgaaaggtg cactgctgga tggcaccagc cgttttagct gtcgtggtaa accgattcat      420

cattttatta gcaccagcac ctttagccag tataccgtgg ttgatgatat tgccgtggca      480

aaaattgatg cagcagcacc gctggataaa gtttgtctga ttggttgtgg ttttagcacc      540

ggttatggta gcgcagttca ggttgcaaaa gttacaccgg gtagcacctg tgcagttttt      600

ggtctgggtg gtgttggtct gagcgttgtt attggttgta aaaccgcagg cgcagcaaaa      660

attattgccg tggatattaa taaagataaa tttgccaaag ccaaagaact gggtgcaacc      720

gattgtatta atccgcagga ttataccaaa ccgattcagg aagttctgca ggaaatgacc      780

gatggtggtg tggattttag ctttgaagtg attggtcgtc tggataccat gaccagcgca      840

ctgctgagct gtcatagcgc atgtggtgtt agcgttattg ttggtgttcc tccgagcgca      900

cagagcctga gcgttaatcc gatgagcctg ctgctgggtc gtacctggaa aggtgcaatt      960

tttggtggct ttaaaagcaa agatgccgtt ccgaaactgg ttgcagattt tatggccaaa     1020

aaatttccgc tggaaccgct gattacccat gttctgccgt ttgaaaaaat taatgaagcc     1080

tttgatctgc tgcgtgcagg taaaagcatt cgtaccgtgc tgacctttta ataa           1134


<210>  13
<211>  1047
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Thermus sp. ATN1 ADH

<400>  13
atgcgtgcag ttgtgtttga aaacaaagaa cgcgtggccg ttaaagaagt taacgcaccg       60

cgtctgcagc atccgctgga tgcactggtt cgtgttcatc tggcaggtat ttgtggtagc      120

gatctgcatc tgtatcatgg taaaattccg gttctgcctg gtagcgttct gggtcatgaa      180

tttgttggtc aggttgaagc agttggtgaa ggtattcagg atctgcagcc tggtgattgg      240

gttgttggtc cgtttcatat tgcatgtggc acctgtccgt attgtcgtcg tcatcagtat      300

aatctgtgtg aacgtggtgg tgtttatggt tatggtccga tgtttggtaa tctgcagggt      360

gcacaggcag aaattctgcg tgttccgttt agcaatgtga atctgcgtaa actgcctccg      420

aatctgtctc cggaacgtgc aatttttgcc ggtgatattc tgagcaccgc ctatggtggt      480

ctgattcagg gtcagctgcg tcctggtgat agcgttgcag ttattggtgc aggtccggtt      540

ggtctgatgg caattgaagt tgcacaggtt ctgggtgcaa gcaaaattct ggccattgat      600

cgtattccgg aacgtctgga acgtgcagca agcctgggtg caattccgat taatgccgaa      660

caggaaaatc cggttcgtcg cgttcgtagc gaaaccaatg atgaaggtcc ggatctggtt      720

ctggaagccg ttggtggtgc agcaaccctg agcctggcac tggaaatggt tcgtcctggt      780

ggtcgtgtta gcgcagttgg tgttgataat gcaccgagct ttccgtttcc gctggcaagc      840

ggtctggtta aagatctgac gtttcgtatt ggtctggcaa atgtgcatct gtatattgat      900

gcagttctgg cactgctggc cagcggtcgt ctgcagccgg aacgtattgt tagccattat      960

ctgccgctgg aagaagcacc tcgcggttac gaactgtttg atcgcaaaga agcactgaaa     1020

gttctgctgg ttgtgcgtgg ttaataa                                         1047


<210>  14
<211>  1041
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Phenylobacteriaum 
       zucineum HLK1 ADH

<400>  14
atgaaagcac tggtttatgg tggtccgggt cagaaaagcc tggaagatcg tccgaaaccg       60

gaactgcagg caccgggtga tgcaattgtt cgtattgtga aaaccaccat ttgtggcacc      120

gatctgcata ttctgaaagg tgatgttgca acctgtgcac cgggtcgtat tctgggtcat      180

gaaggtgttg gtattgttga tagcgttggt gcagcagtta ccgcatttcg tccgggtgat      240

catgttctga ttagctgtat tagcgcctgt ggtaaatgtg attattgccg tcgtggtatg      300

tatagccatt gtacaaccgg tggatggatt ctgggtaatg aaattgatgg cacccaggca      360

gaatatgttc gtacaccgca tgcagatacc agcctgtatc cggttccggc aggcgcagat      420

gaagaggcac tggttatgct gagcgatatt ctgccgaccg gttttgaatg tggtgtgctg      480

aatggtaaag ttgcaccggg tggcaccgtt gcaattgttg gtgcaggtcc gattggtctg      540

gcagcactgc tgaccgcaca gttttattct ccggcagaaa ttattatgat tgatctggat      600

gataatcgtc tgggtattgc acgtcagttt ggtgcaaccc agaccattaa tagcggtgat      660

ggtcgtgcag cagaaaccgt taaagcactg accggtggtc gtggtgttga taccgcaatt      720

gaagcagttg gtgttccggc aacctttgaa ctgtgtcagg atctggttgg tcctggtggt      780

gttattgcaa atattggtgt gcatggtcgt aaagttgatc tgcatctgga tcgtctgtgg      840

agccagaata ttgcaattac cacccgtctg gttgataccg ttagcacccc gatgctgctg      900

aaaaccgttc agagccgtaa actggacccg agccagctga ttacccatcg ttttcgcctg      960

gatgaaattc tggcagccta tgataccttt gcacgtgcag cagataccca ggcactgaaa     1020

gttattattg cagcctaata a                                               1041


<210>  15
<211>  1041
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Methlyoceclla silvestris 
       BL2 ADH

<400>  15
atgaaagcac tggtttatca tggtccgggt cagaaagcac tggaagaacg tccgaaaccg       60

cagattgaag caagcggtga tgccattgtt aaaattgtga aaaccaccat ttgtggcacc      120

gatctgcata ttctgaaagg tgatgttgca acctgtgcac cgggtcgtat tctgggtcat      180

gaaggtgtgg gtattattga tagcgttggt gccggtgtta ccgcatttca gcctggtgat      240

cgtgttctga ttagctgtat tagcagctgt ggcaaatgtg attattgtcg tcgtggtctg      300

tatagccatt gtacaaccgg tggttggatt ctgggtaatg aaattgatgg cacccaggca      360

gaatatgttc gtacaccgca tgcagatacc agcctgtatc gtattccggc aggcgcagat      420

gaagaggcac tggttatgct gagcgatatt ctgccgaccg gttttgaatg tggtgtgctg      480

aatggtaaag ttgaaccggg tagcaccgtt gcaattgttg gtgcaggtcc gattggtctg      540

gcagcactgc tgaccgcaca gttttatgca ccgggtgata ttattatgat tgatctggat      600

gataatcgtc tggatgttgc acgtcgtttt ggtgcaaccc ataccattaa tagcggtgat      660

ggtaaagcag cagaagcagt taaagcactg accggtggta ttggtgttga taccgcaatt      720

gaagccgttg gtattccggc aacctttctg ctgtgtgaag atattgttgc accgggtggt      780

gttattgcaa atgttggtgt gcatggtgtt aaagttgatc tgcatctgga acgtctgtgg      840

gcacataata ttaccattac cacccgtctg gttgataccg ttaccacccc gatgctgctg      900

aaaaccgttc agagcaaaaa actggacccg ctgcagctga ttacccatcg ttttaccctg      960

gatcatattc tggatgccta tgataccttt agccgtgcag cagataccaa agccctgaaa     1020

gttattgtga gcgcctaata a                                               1041


<210>  16
<211>  1086
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Acinetobacter baumannii 
       AYE ADH

<400>  16
atggaaaata ttatgaaagc aatggtgtat tatggcgatc atgatattcg ttttgaagaa       60

cgcaaaaaac cggaactgat tgatccgacc gatgccatta ttaaaatgac caaaaccacc      120

atttgtggca ccgatctggg tatttataaa ggcaaaaatc cggaaattga acagaaagaa      180

caggaaaaaa acggcagctt taatggtcgt attctgggtc atgaaggtat tggtattgtg      240

gagcagattg gtagcagcgt gaaaaacatt aaagtgggcg ataaagttat tgttagctgc      300

gttagccgtt gtggcacctg tgaaaattgt gccaaacagc tgtatagcca ttgtcgtaat      360

gatggtggtt ggattatggg ctatatgatt gatggcaccc aggcagaata tgttcgtacc      420

ccgtttgcag ataccagcct gtatgttctg ccggaaggtc tgaatgaaga tgttgcagtt      480

ctgctgtctg atgcactgcc gaccgcacat gaaattggtg ttcagaatgg cgatattaaa      540

ccgggtgata ccgttgcaat tgttggtgca ggtccggttg gtatgagcgc actgctgacc      600

gctcagtttt atagcccgag ccagattatt atgattgata tggatgaaaa tcgtctggca      660

atggcaaaag aactgggtgc aaccgatacc attaatagcg gcaccgaaga tgcaattgca      720

cgtgttatgg aactgaccaa tcagcgtggt gttgattgtg caattgaagc cgttggtatt      780

gaaccgacct gggatatttg tcagaatatt gtgaaagaag gtggtcatct ggcaaatgtt      840

ggtgttcatg gcaaaagcgt gaattttagc ctggaaaaac tgtggattaa aaatctgacc      900

attaccaccg gtctggttaa tgcaaatacc accggtatgc tgctgaaaag ctgttgtagc      960

ggtaaactgc cgatggaaaa actggcaacc catcatttta aatttaatga aattgaaaag     1020

gcctatgatg tgtttattaa tgcagccaaa gaaaaagcca tgaaagtgat tattgatttt     1080

taataa                                                                1086


<210>  17
<211>  1044
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Geobacillus sp. WCH70 ADH

<400>  17
atgaaagcac tgacctatct gggtccgggt aaaaaagaag tgatggaaaa accgaaaccg       60

aaaattgaaa aagaaaccga tgccattgtg aaaattacca aaaccaccat ttgtggcacc      120

gatctgcata ttctgagcgg tgatgttccg accgttgaag aaggtcgtat tctgggtcat      180

gaaggtgtgg gtattattga agaagttggc tctggcgtta aaaattttaa aaaaggcgat      240

cgcgttctga ttagctgtat taccagctgt ggcaaatgcg aaaattgcaa aaaaggcctg      300

tatgcccatt gtgaagatgg tggttggatt ctgggccatc tgattgatgg cacccaggca      360

gaatatgttc gtattccgca tgcagataat agcctgtatc cgattccgga aggtgttgat      420

gaagaggcac tggttatgct gagcgatatt ctgccgaccg gttttgaaat tggtgtgctg      480

aatggtaaag ttcagcctgg tcagaccgtt gcaattattg gtgcaggtcc ggttggtatg      540

gcagcactgc tgaccgcaca gttttattct ccggcagaaa ttattatggt ggatctggat      600

gataatcgtc tggaagtggc caaaaaattt ggtgcaaccc aggttgttaa tagcgcagat      660

ggtaaagccg tggaaaaaat tatggaactg accggtggca aaggtgtgga tgttgcaatg      720

gaagcagttg gtattccggt gacctttgat atttgccagg aaattgttaa acctggcggt      780

tatattgcaa atattggcgt gcatggtaaa agcgtggaat ttcatattga aaaactgtgg      840

attcgcaaca ttaccctgac caccggtctg gttaatacca cctctacccc gatgctgctg      900

aaaaccgttc agagcaaaaa actgaaaccg gaacagctga ttacccatcg ttttgccttt      960

gccgatatta tgaaagccta tgaagtgttt ggtaatgcag ccaaagaaaa agccctgaaa     1020

gtgattatta gcaatgatta ataa                                            1044


<210>  18
<211>  1086
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Vanderwaltozyma polyspora
       DSM 70294 ADH

<400>  18
atgagctatc cggaaaaatt tcagggtatt ggcattacca atcgcgaaga ttggaaacat       60

ccgaaaaaag tgacctttga accgaaacag tttaatgata aagatgtgga tattaaaatt      120

gaagcctgcg gtgtttgtgg ttctgatgtt cattgtgcag caagccattg gggtccggtt      180

gcagaaaaac aggttgtggg ccatgaaatt attggtcgtg tgctgaaagt tggtccgaaa      240

tgtaccaccg gtattaaagt tggtgatcgt gttggtgttg gtgcacaggc atggtcttgt      300

ctggaatgta gccgttgcaa aagcgataat gaaagctatt gtccgaaaag cgtttggacc      360

tatagcattc cgtatattga tggttatgtt agccagggtg gttatgcaag ccatattcgc      420

ctgcatgaac attttgcaat tccgattccg gataaactga gcaatgaact ggcagcaccg      480

ctgctgtgtg gtggtattac cgtttattct ccgctgctgc gtaatggttg tggtccgggt      540

aaaaaagttg gtattgtggg cattggtggt attggtcaca tgggtctgct gtttgcaaaa      600

ggtatgggtg ccgaagttta tgcatttagc cgcacccata gcaaagaggc agacgccaaa      660

aaactgggtg ccgatcattt tattgcaacc ctggaagata aagattggac caccaaatat      720

tttgataccc tggatctgct ggttatttgt gcaagcagcc tgaccgatat taattttgat      780

gaactgacca aaattatgaa agtgaatacc aaaattatta gcattagcgc accggcagca      840

gatgaagttc tgaccctgaa accgtttggt ctgattggtg tgaccattgg taatagcgca      900

attggtagcc gtcgtgaaat tgaacatctg ctgaattttg tggccgaaaa agatattaaa      960

ccgtgggttg aaaccctgcc ggttggtgaa gccggtgtta atgaagcatt tgaacgcatg     1020

gataaaggtg atgtgaaata tcgttttacc ctggtggatt ttgataaaga atttggcaat     1080

taataa                                                                1086


<210>  19
<211>  1050
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Mucor circinelloides ADH

<400>  19
atgagcgaag aaacctttac cgcatgggca tgtaaaagca aaagcgcacc gctggaaccg       60

atggaaatga ccttttgcca ttgggatgat gatatggttc agatggatgt tatttgttgt      120

ggtgtttgtg gcaccgatct gcataccgtt gatgaaggtt ggggtccgac cgaatttccg      180

tgtgttgtgg gccatgaaat tattggcaat gtgaccaaag tgggtaaaaa tgtgacccgt      240

attaaagttg gtgatcgttg tggtgttggt tgtcagagcg caagctgtgg taaatgcgat      300

ttttgcaaaa aaggcatgga aaatctgtgt agcacccatg cagtttggac ctttaatgat      360

cgctatgata atgccaccaa agataaaacc tatggtggct ttgcaaaaaa atggcgtggc      420

aatcaggatt ttgttgttca tgtgccgatg gatttttctc cggaagttgc agcaagcttt      480

ctgtgtggtg gtgttaccac ctatgcaccg ctgaaacgtt atggtgttgg taaaggtagc      540

aaagttgcag ttctgggtct gggtggtctg ggccattttg gtgttcagtg ggcaaaagca      600

atgggtgcag aagttgttgc ctttgacgtg attccggata aagtggatga tgccaaaaaa      660

ctgggctgtg atgattatgt tctgatgcag aaagaagagc agatggaacc gcattataat      720

acctttaccc atattctggc caccaaaatt gtgaataaat gctgggatca gtattttaaa      780

atgctgaaaa ataatggcat ttttatgctg tgcgatattc cggaagttcc gctgagcggt      840

atgagcgcat ttgttatggc aggtaaacag ctgaccattg caggcacctt tattggtagc      900

ccgagcgtta ttcaggaatg tctggatttt gcagccaagc ataatgttcg tacctgggtt      960

aatacctttc cgatggaaaa aattaatgaa gcctttgaat ttgttcgtca ggcaaaaccg     1020

cgttatcgtg ccgttgtgat gaattaataa                                      1050


<210>  20
<211>  1056
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized polynucleotide sequence-Rhodococcus erythropolis 
       PR4 ADH

<400>  20
atgtttaccg ttaatgcacg tagcaccagc gcaccgggtg caccgtttga agcagttgtt       60

attgaacgtc gtgatccggg tccgggtgat gttgttattg atattgcctt tagcggtatt      120

tgtcataccg atgttagccg tgcacgtagc gaatttggca ccacccatta tccgctggtt      180

ccgggtcatg aaattgccgg tgttgttagc aaagttggtt ccgatgttac caaatttgca      240

gttggtgatc gtgttggtgt tggttgtatt gttgatagct gccgtgaatg tgattattgt      300

cgtgcaggtc tggaaccgta ttgtcgtaaa gatcatgtgc gcacctataa tagcatgggt      360

cgtgatggtc gtattaccct gggtggttat agcgaaaaaa ttgtggtgga tgaaggttat      420

gttctgcgta ttccggatgc aattccgctg gatcaggcag caccgctgct gtgtgcaggt      480

attaccatgt attctccgct gcgtcattgg aaagcaggtc cgggtagccg tattgcaatt      540

gttggttttg gtggtctggg tcatgttggt gttgcaattg cacgtgcact gggtgcacat      600

accaccgttt ttgatctgac gatggataaa catgatgatg caattcgtct gggtgcagat      660

gattatcgtc tgagcaccga tgcaggcatt tttaaagaat ttgaaggtgc ctttgaactg      720

attgttagca ccgttccggc aaatctggat tatgacctgt ttctgaaaat gctggcactg      780

gatggcacct ttgttcagct gggtgttccg cataatccgg ttagcctgga tgtttttagc      840

ctgttttata atcgtcgtag cctggcaggc accctggttg gtggtattgg tgaaacccag      900

gaaatgctgg atttttgcgc agaacatagc attgttgccg aaattgaaac cgttggtgcc      960

gatgaaattg atagcgccta tgatcgtgtt gcagccggtg atgttcgtta tcgtatggtt     1020

ctggatgttg gcaccctggc aacccagcgt taataa                               1056


<210>  21
<211>  375
<212>  PRT
<213>  Equus caballus

<400>  21

Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      


Glu Glu Lys Lys Pro Phe Ser Ile Glu Glu Val Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala His Glu Val Arg Ile Lys Met Val Ala Thr Gly Ile Cys Arg 
        35                  40                  45              


Ser Asp Asp His Val Val Ser Gly Thr Leu Val Thr Pro Leu Pro Val 
    50                  55                  60                  


Ile Ala Gly His Glu Ala Ala Gly Ile Val Glu Ser Ile Gly Glu Gly 
65                  70                  75                  80  


Val Thr Thr Val Arg Pro Gly Asp Lys Val Ile Pro Leu Phe Thr Pro 
                85                  90                  95      


Gln Cys Gly Lys Cys Arg Val Cys Lys His Pro Glu Gly Asn Phe Cys 
            100                 105                 110         


Leu Lys Asn Asp Leu Ser Met Pro Arg Gly Thr Met Gln Asp Gly Thr 
        115                 120                 125             


Ser Arg Phe Thr Cys Arg Gly Lys Pro Ile His His Phe Leu Gly Thr 
    130                 135                 140                 


Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Ile Ser Val Ala Lys 
145                 150                 155                 160 


Ile Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly 
                165                 170                 175     


Phe Ser Thr Gly Tyr Gly Ser Ala Val Lys Val Ala Lys Val Thr Gln 
            180                 185                 190         


Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val 
        195                 200                 205             


Ile Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Gly Val Asp 
    210                 215                 220                 


Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Val Gly Ala Thr Glu 
225                 230                 235                 240 


Cys Val Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Thr 
                245                 250                 255     


Glu Met Ser Asn Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg 
            260                 265                 270         


Leu Asp Thr Met Val Thr Ala Leu Ser Cys Cys Gln Glu Ala Tyr Gly 
        275                 280                 285             


Val Ser Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met 
    290                 295                 300                 


Asn Pro Met Leu Leu Leu Ser Gly Arg Thr Trp Lys Gly Ala Ile Phe 
305                 310                 315                 320 


Gly Gly Phe Lys Ser Lys Asp Ser Val Pro Lys Leu Val Ala Asp Phe 
                325                 330                 335     


Met Ala Lys Lys Phe Ala Leu Asp Pro Leu Ile Thr His Val Leu Pro 
            340                 345                 350         


Phe Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu Arg Ser Gly Glu Ser 
        355                 360                 365             


Ile Arg Thr Ile Leu Thr Phe 
    370                 375 


<210>  22
<211>  360
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  22

Met Ser Tyr Pro Glu Lys Phe Glu Gly Ile Ala Ile Gln Ser His Glu 
1               5                   10                  15      


Asp Trp Lys Asn Pro Lys Lys Thr Lys Tyr Asp Pro Lys Pro Phe Tyr 
            20                  25                  30          


Asp His Asp Ile Asp Ile Lys Ile Glu Ala Cys Gly Val Cys Gly Ser 
        35                  40                  45              


Asp Ile His Cys Ala Ala Gly His Trp Gly Asn Met Lys Met Pro Leu 
    50                  55                  60                  


Val Val Gly His Glu Ile Val Gly Lys Val Val Lys Leu Gly Pro Lys 
65                  70                  75                  80  


Ser Asn Ser Gly Leu Lys Val Gly Gln Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Val Phe Ser Cys Leu Glu Cys Asp Arg Cys Lys Asn Asp Asn Glu Pro 
            100                 105                 110         


Tyr Cys Thr Lys Phe Val Thr Thr Tyr Ser Gln Pro Tyr Glu Asp Gly 
        115                 120                 125             


Tyr Val Ser Gln Gly Gly Tyr Ala Asn Tyr Val Arg Val His Glu His 
    130                 135                 140                 


Phe Val Val Pro Ile Pro Glu Asn Ile Pro Ser His Leu Ala Ala Pro 
145                 150                 155                 160 


Leu Leu Cys Gly Gly Leu Thr Val Tyr Ser Pro Leu Val Arg Asn Gly 
                165                 170                 175     


Cys Gly Pro Gly Lys Lys Val Gly Ile Val Gly Leu Gly Gly Ile Gly 
            180                 185                 190         


Ser Met Gly Thr Leu Ile Ser Lys Ala Met Gly Ala Glu Thr Tyr Val 
        195                 200                 205             


Ile Ser Arg Ser Ser Arg Lys Arg Glu Asp Ala Met Lys Met Gly Ala 
    210                 215                 220                 


Asp His Tyr Ile Ala Thr Leu Glu Glu Gly Asp Trp Gly Glu Lys Tyr 
225                 230                 235                 240 


Phe Asp Thr Phe Asp Leu Ile Val Val Cys Ala Ser Ser Leu Thr Asp 
                245                 250                 255     


Ile Asp Phe Asn Ile Met Pro Lys Ala Met Lys Val Gly Gly Arg Ile 
            260                 265                 270         


Val Ser Ile Ser Ile Pro Glu Gln His Glu Met Leu Ser Leu Lys Pro 
        275                 280                 285             


Tyr Gly Leu Lys Ala Val Ser Ile Ser Tyr Ser Ala Leu Gly Ser Ile 
    290                 295                 300                 


Lys Glu Leu Asn Gln Leu Leu Lys Leu Val Ser Glu Lys Asp Ile Lys 
305                 310                 315                 320 


Ile Trp Val Glu Thr Leu Pro Val Gly Glu Ala Gly Val His Glu Ala 
                325                 330                 335     


Phe Glu Arg Met Glu Lys Gly Asp Val Arg Tyr Arg Phe Thr Leu Val 
            340                 345                 350         


Gly Tyr Asp Lys Glu Phe Ser Asp 
        355                 360 


<210>  23
<211>  361
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  23

Met Leu Tyr Pro Glu Lys Phe Gln Gly Ile Gly Ile Ser Asn Ala Lys 
1               5                   10                  15      


Asp Trp Lys His Pro Lys Leu Val Ser Phe Asp Pro Lys Pro Phe Gly 
            20                  25                  30          


Asp His Asp Val Asp Val Glu Ile Glu Ala Cys Gly Ile Cys Gly Ser 
        35                  40                  45              


Asp Phe His Ile Ala Val Gly Asn Trp Gly Pro Val Pro Glu Asn Gln 
    50                  55                  60                  


Ile Leu Gly His Glu Ile Ile Gly Arg Val Val Lys Val Gly Ser Lys 
65                  70                  75                  80  


Cys His Thr Gly Val Lys Ile Gly Asp Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Ala Leu Ala Cys Phe Glu Cys Glu Arg Cys Lys Ser Asp Asn Glu Gln 
            100                 105                 110         


Tyr Cys Thr Asn Asp His Val Leu Thr Met Trp Thr Pro Tyr Lys Asp 
        115                 120                 125             


Gly Tyr Ile Ser Gln Gly Gly Phe Ala Ser His Val Arg Leu His Glu 
    130                 135                 140                 


His Phe Ala Ile Gln Ile Pro Glu Asn Ile Pro Ser Pro Leu Ala Ala 
145                 150                 155                 160 


Pro Leu Leu Cys Gly Gly Ile Thr Val Phe Ser Pro Leu Leu Arg Asn 
                165                 170                 175     


Gly Cys Gly Pro Gly Lys Arg Val Gly Ile Val Gly Ile Gly Gly Ile 
            180                 185                 190         


Gly His Met Gly Ile Leu Leu Ala Lys Ala Met Gly Ala Glu Val Tyr 
        195                 200                 205             


Ala Phe Ser Arg Gly His Ser Lys Arg Glu Asp Ser Met Lys Leu Gly 
    210                 215                 220                 


Ala Asp His Tyr Ile Ala Met Leu Glu Asp Lys Gly Trp Thr Glu Gln 
225                 230                 235                 240 


Tyr Ser Asn Ala Leu Asp Leu Leu Val Val Cys Ser Ser Ser Leu Ser 
                245                 250                 255     


Lys Val Asn Phe Asp Ser Ile Val Lys Ile Met Lys Ile Gly Gly Ser 
            260                 265                 270         


Ile Val Ser Ile Ala Ala Pro Glu Val Asn Glu Lys Leu Val Leu Lys 
        275                 280                 285             


Pro Leu Gly Leu Met Gly Val Ser Ile Ser Ser Ser Ala Ile Gly Ser 
    290                 295                 300                 


Arg Lys Glu Ile Glu Gln Leu Leu Lys Leu Val Ser Glu Lys Asn Val 
305                 310                 315                 320 


Lys Ile Trp Val Glu Lys Leu Pro Ile Ser Glu Glu Gly Val Ser His 
                325                 330                 335     


Ala Phe Thr Arg Met Glu Ser Gly Asp Val Lys Tyr Arg Phe Thr Leu 
            340                 345                 350         


Val Asp Tyr Asp Lys Lys Phe His Lys 
        355                 360     


<210>  24
<211>  389
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  24

Met Leu Ser Phe Asp Tyr Ser Ile Pro Thr Lys Val Phe Phe Gly Lys 
1               5                   10                  15      


Gly Lys Ile Asp Val Ile Gly Glu Glu Ile Lys Lys Tyr Gly Ser Arg 
            20                  25                  30          


Val Leu Ile Val Tyr Gly Gly Gly Ser Ile Lys Arg Asn Gly Ile Tyr 
        35                  40                  45              


Asp Arg Ala Thr Ala Ile Leu Lys Glu Asn Asn Ile Ala Phe Tyr Glu 
    50                  55                  60                  


Leu Ser Gly Val Glu Pro Asn Pro Arg Ile Thr Thr Val Lys Lys Gly 
65                  70                  75                  80  


Ile Glu Ile Cys Arg Glu Asn Asn Val Asp Leu Val Leu Ala Ile Gly 
                85                  90                  95      


Gly Gly Ser Ala Ile Asp Cys Ser Lys Val Ile Ala Ala Gly Val Tyr 
            100                 105                 110         


Tyr Asp Gly Asp Thr Trp Asp Met Val Lys Asp Pro Ser Lys Ile Thr 
        115                 120                 125             


Lys Val Leu Pro Ile Ala Ser Ile Leu Thr Leu Ser Ala Thr Gly Ser 
    130                 135                 140                 


Glu Met Asp Gln Ile Ala Val Ile Ser Asn Met Glu Thr Asn Glu Lys 
145                 150                 155                 160 


Leu Gly Val Gly His Asp Asp Met Arg Pro Lys Phe Ser Val Leu Asp 
                165                 170                 175     


Pro Thr Tyr Thr Phe Thr Val Pro Lys Asn Gln Thr Ala Ala Gly Thr 
            180                 185                 190         


Ala Asp Ile Met Ser His Thr Phe Glu Ser Tyr Phe Ser Gly Val Glu 
        195                 200                 205             


Gly Ala Tyr Val Gln Asp Gly Ile Arg Glu Ala Ile Leu Arg Thr Cys 
    210                 215                 220                 


Ile Lys Tyr Gly Lys Ile Ala Met Glu Lys Thr Asp Asp Tyr Glu Ala 
225                 230                 235                 240 


Arg Ala Asn Leu Met Trp Ala Ser Ser Leu Ala Ile Asn Gly Leu Leu 
                245                 250                 255     


Ser Leu Gly Lys Asp Arg Lys Trp Ser Cys His Pro Met Glu His Glu 
            260                 265                 270         


Leu Ser Ala Tyr Tyr Asp Ile Thr His Gly Val Gly Leu Ala Ile Leu 
        275                 280                 285             


Thr Pro Asn Trp Met Glu Tyr Ile Leu Asn Asp Asp Thr Leu His Lys 
    290                 295                 300                 


Phe Val Ser Tyr Gly Ile Asn Val Trp Gly Ile Asp Lys Asn Lys Asp 
305                 310                 315                 320 


Asn Tyr Glu Ile Ala Arg Glu Ala Ile Lys Asn Thr Arg Glu Tyr Phe 
                325                 330                 335     


Asn Ser Leu Gly Ile Pro Ser Lys Leu Arg Glu Val Gly Ile Gly Lys 
            340                 345                 350         


Asp Lys Leu Glu Leu Met Ala Lys Gln Ala Val Arg Asn Ser Gly Gly 
        355                 360                 365             


Thr Ile Gly Ser Leu Arg Pro Ile Asn Ala Glu Asp Val Leu Glu Ile 
    370                 375                 380                 


Phe Lys Lys Ser Tyr 
385                 


<210>  25
<211>  390
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  25

Met Val Asp Phe Glu Tyr Ser Ile Pro Thr Arg Ile Phe Phe Gly Lys 
1               5                   10                  15      


Asp Lys Ile Asn Val Leu Gly Arg Glu Leu Lys Lys Tyr Gly Ser Lys 
            20                  25                  30          


Val Leu Ile Val Tyr Gly Gly Gly Ser Ile Lys Arg Asn Gly Ile Tyr 
        35                  40                  45              


Asp Lys Ala Val Ser Ile Leu Glu Lys Asn Ser Ile Lys Phe Tyr Glu 
    50                  55                  60                  


Leu Ala Gly Val Glu Pro Asn Pro Arg Val Thr Thr Val Glu Lys Gly 
65                  70                  75                  80  


Val Lys Ile Cys Arg Glu Asn Gly Val Glu Val Val Leu Ala Ile Gly 
                85                  90                  95      


Gly Gly Ser Ala Ile Asp Cys Ala Lys Val Ile Ala Ala Ala Cys Glu 
            100                 105                 110         


Tyr Asp Gly Asn Pro Trp Asp Ile Val Leu Asp Gly Ser Lys Ile Lys 
        115                 120                 125             


Arg Val Leu Pro Ile Ala Ser Ile Leu Thr Ile Ala Ala Thr Gly Ser 
    130                 135                 140                 


Glu Met Asp Thr Trp Ala Val Ile Asn Asn Met Asp Thr Asn Glu Lys 
145                 150                 155                 160 


Leu Ile Ala Ala His Pro Asp Met Ala Pro Lys Phe Ser Ile Leu Asp 
                165                 170                 175     


Pro Thr Tyr Thr Tyr Thr Val Pro Thr Asn Gln Thr Ala Ala Gly Thr 
            180                 185                 190         


Ala Asp Ile Met Ser His Ile Phe Glu Val Tyr Phe Ser Asn Thr Lys 
        195                 200                 205             


Thr Ala Tyr Leu Gln Asp Arg Met Ala Glu Ala Leu Leu Arg Thr Cys 
    210                 215                 220                 


Ile Lys Tyr Gly Gly Ile Ala Leu Glu Lys Pro Asp Asp Tyr Glu Ala 
225                 230                 235                 240 


Arg Ala Asn Leu Met Trp Ala Ser Ser Leu Ala Ile Asn Gly Leu Leu 
                245                 250                 255     


Thr Tyr Gly Lys Asp Thr Asn Trp Ser Val His Leu Met Glu His Glu 
            260                 265                 270         


Leu Ser Ala Tyr Tyr Asp Ile Thr His Gly Val Gly Leu Ala Ile Leu 
        275                 280                 285             


Thr Pro Asn Trp Met Glu Tyr Ile Leu Asn Asn Asp Thr Val Tyr Lys 
    290                 295                 300                 


Phe Val Glu Tyr Gly Val Asn Val Trp Gly Ile Asp Lys Glu Lys Asn 
305                 310                 315                 320 


His Tyr Asp Ile Ala His Gln Ala Ile Gln Lys Thr Arg Asp Tyr Phe 
                325                 330                 335     


Val Asn Val Leu Gly Leu Pro Ser Arg Leu Arg Asp Val Gly Ile Glu 
            340                 345                 350         


Glu Glu Lys Leu Asp Ile Met Ala Lys Glu Ser Val Lys Leu Thr Gly 
        355                 360                 365             


Gly Thr Ile Gly Asn Leu Arg Pro Val Asn Ala Ser Glu Val Leu Gln 
    370                 375                 380                 


Ile Phe Lys Lys Ser Val 
385                 390 


<210>  26
<211>  348
<212>  PRT
<213>  Achromobacter xylosoxidans

<400>  26

Met Lys Ala Leu Val Tyr His Gly Asp His Lys Ile Ser Leu Glu Asp 
1               5                   10                  15      


Lys Pro Lys Pro Thr Leu Gln Lys Pro Thr Asp Val Val Val Arg Val 
            20                  25                  30          


Leu Lys Thr Thr Ile Cys Gly Thr Asp Leu Gly Ile Tyr Lys Gly Lys 
        35                  40                  45              


Asn Pro Glu Val Ala Asp Gly Arg Ile Leu Gly His Glu Gly Val Gly 
    50                  55                  60                  


Val Ile Glu Glu Val Gly Glu Ser Val Thr Gln Phe Lys Lys Gly Asp 
65                  70                  75                  80  


Lys Val Leu Ile Ser Cys Val Thr Ser Cys Gly Ser Cys Asp Tyr Cys 
                85                  90                  95      


Lys Lys Gln Leu Tyr Ser His Cys Arg Asp Gly Gly Trp Ile Leu Gly 
            100                 105                 110         


Tyr Met Ile Asp Gly Val Gln Ala Glu Tyr Val Arg Ile Pro His Ala 
        115                 120                 125             


Asp Asn Ser Leu Tyr Lys Ile Pro Gln Thr Ile Asp Asp Glu Ile Ala 
    130                 135                 140                 


Val Leu Leu Ser Asp Ile Leu Pro Thr Gly His Glu Ile Gly Val Gln 
145                 150                 155                 160 


Tyr Gly Asn Val Gln Pro Gly Asp Ala Val Ala Ile Val Gly Ala Gly 
                165                 170                 175     


Pro Val Gly Met Ser Val Leu Leu Thr Ala Gln Phe Tyr Ser Pro Ser 
            180                 185                 190         


Thr Ile Ile Val Ile Asp Met Asp Glu Asn Arg Leu Gln Leu Ala Lys 
        195                 200                 205             


Glu Leu Gly Ala Thr His Thr Ile Asn Ser Gly Thr Glu Asn Val Val 
    210                 215                 220                 


Glu Ala Val His Arg Ile Ala Ala Glu Gly Val Asp Val Ala Ile Glu 
225                 230                 235                 240 


Ala Val Gly Ile Pro Ala Thr Trp Asp Ile Cys Gln Glu Ile Val Lys 
                245                 250                 255     


Pro Gly Ala His Ile Ala Asn Val Gly Val His Gly Val Lys Val Asp 
            260                 265                 270         


Phe Glu Ile Gln Lys Leu Trp Ile Lys Asn Leu Thr Ile Thr Thr Gly 
        275                 280                 285             


Leu Val Asn Thr Asn Thr Thr Pro Met Leu Met Lys Val Ala Ser Thr 
    290                 295                 300                 


Asp Lys Leu Pro Leu Lys Lys Met Ile Thr His Arg Phe Glu Leu Ala 
305                 310                 315                 320 


Glu Ile Glu His Ala Tyr Gln Val Phe Leu Asn Gly Ala Lys Glu Lys 
                325                 330                 335     


Ala Met Lys Ile Ile Leu Ser Asn Ala Gly Ala Ala Met Lys Ala Leu 
            340                 345             1               


Val Tyr His Gly Asp His Lys Ile Ser Leu Glu Asp Lys Pro Lys Pro 
5                   10                  15                  20  


Thr Leu Gln Lys Pro Thr Asp Val Val Val Arg Val Leu Lys Thr Thr 
                25                  30                  35      


Ile Cys Gly Thr Asp Leu Gly Ile Tyr Lys Gly Lys Asn Pro Glu Val 
            40                  45                  50          


Ala Asp Gly Arg Ile Leu Gly His Glu Gly Val Gly Val Ile Glu Glu 
        55                  60                  65              


Val Gly Glu Ser Val Thr Gln Phe Lys Lys Gly Asp Lys Val Leu Ile 
    70                  75                  80                  


Ser Cys Val Thr Ser Cys Gly Ser Cys Asp Tyr Cys Lys Lys Gln Leu 
85                  90                  95                  100 


Tyr Ser His Cys Arg Asp Gly Gly Trp Ile Leu Gly Tyr Met Ile Asp 
                105                 110                 115     


Gly Val Gln Ala Glu Tyr Val Arg Ile Pro His Ala Asp Asn Ser Leu 
            120                 125                 130         


Tyr Lys Ile Pro Gln Thr Ile Asp Asp Glu Ile Ala Val Leu Leu Ser 
        135                 140                 145             


Asp Ile Leu Pro Thr Gly His Glu Ile Gly Val Gln Tyr Gly Asn Val 
    150                 155                 160                 


Gln Pro Gly Asp Ala Val Ala Ile Val Gly Ala Gly Pro Val Gly Met 
165                 170                 175                 180 


Ser Val Leu Leu Thr Ala Gln Phe Tyr Ser Pro Ser Thr Ile Ile Val 
                185                 190                 195     


Ile Asp Met Asp Glu Asn Arg Leu Gln Leu Ala Lys Glu Leu Gly Ala 
            200                 205                 210         


Thr His Thr Ile Asn Ser Gly Thr Glu Asn Val Val Glu Ala Val His 
        215                 220                 225             


Arg Ile Ala Ala Glu Gly Val Asp Val Ala Ile Glu Ala Val Gly Ile 
    230                 235                 240                 


Pro Ala Thr Trp Asp Ile Cys Gln Glu Ile Val Lys Pro Gly Ala His 
245                 250                 255                 260 


Ile Ala Asn Val Gly Val His Gly Val Lys Val Asp Phe Glu Ile Gln 
                265                 270                 275     


Lys Leu Trp Ile Lys Asn Leu Thr Ile Thr Thr Gly Leu Val Asn Thr 
            280                 285                 290         


Asn Thr Thr Pro Met Leu Met Lys Val Ala Ser Thr Asp Lys Leu Pro 
        295                 300                 305             


Leu Lys Lys Met Ile Thr His Arg Phe Glu Leu Ala Glu Ile Glu His 
    310                 315                 320                 


Ala Tyr Gln Val Phe Leu Asn Gly Ala Lys Glu Lys Ala Met Lys Ile 
325                 330                 335                 340 


Ile Leu Ser Asn Ala Gly Ala Ala 
                345             


<210>  27
<211>  325
<212>  PRT
<213>  Bos taurus

<400>  27

Met Ala Ala Ser Cys Ile Leu Leu His Thr Gly Gln Lys Met Pro Leu 
1               5                   10                  15      


Ile Gly Leu Gly Thr Trp Lys Ser Asp Pro Gly Gln Val Lys Ala Ala 
            20                  25                  30          


Ile Lys Tyr Ala Leu Ser Val Gly Tyr Arg His Ile Asp Cys Ala Ala 
        35                  40                  45              


Ile Tyr Gly Asn Glu Thr Glu Ile Gly Glu Ala Leu Lys Glu Asn Val 
    50                  55                  60                  


Gly Pro Gly Lys Leu Val Pro Arg Glu Glu Leu Phe Val Thr Ser Lys 
65                  70                  75                  80  


Leu Trp Asn Thr Lys His His Pro Glu Asp Val Glu Pro Ala Leu Arg 
                85                  90                  95      


Lys Thr Leu Ala Asp Leu Gln Leu Glu Tyr Leu Asp Leu Tyr Leu Met 
            100                 105                 110         


His Trp Pro Tyr Ala Phe Glu Arg Gly Asp Ser Pro Phe Pro Lys Asn 
        115                 120                 125             


Ala Asp Gly Thr Ile Arg Tyr Asp Ser Thr His Tyr Lys Glu Thr Trp 
    130                 135                 140                 


Arg Ala Leu Glu Ala Leu Val Ala Lys Gly Leu Val Arg Ala Leu Gly 
145                 150                 155                 160 


Leu Ser Asn Phe Asn Ser Arg Gln Ile Asp Asp Val Leu Ser Val Ala 
                165                 170                 175     


Ser Val Arg Pro Ala Val Leu Gln Val Glu Cys His Pro Tyr Leu Ala 
            180                 185                 190         


Gln Asn Glu Leu Ile Ala His Cys Gln Ala Arg Asn Leu Glu Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Ser Asp Arg Ala Trp Arg Asp Pro Glu 
    210                 215                 220                 


Glu Pro Val Leu Leu Lys Glu Pro Val Val Leu Ala Leu Ala Glu Lys 
225                 230                 235                 240 


His Gly Arg Ser Pro Ala Gln Ile Leu Leu Arg Trp Gln Val Gln Arg 
                245                 250                 255     


Lys Val Ser Cys Ile Pro Lys Ser Val Thr Pro Ser Arg Ile Leu Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Thr Phe Ser Pro Glu Glu Met Lys Gln 
        275                 280                 285             


Leu Asp Ala Leu Asn Lys Asn Leu Arg Phe Ile Val Pro Met Leu Thr 
    290                 295                 300                 


Val Asp Gly Lys Arg Val Pro Arg Asp Ala Gly His Pro Leu Tyr Pro 
305                 310                 315                 320 


Phe Asn Asp Pro Tyr 
                325 


<210>  28
<211>  373
<212>  PRT
<213>  Rama perezi

<400>  28

Met Cys Thr Ala Gly Lys Asp Ile Thr Cys Lys Ala Ala Val Ala Trp 
1               5                   10                  15      


Glu Pro His Lys Pro Leu Ser Leu Glu Thr Ile Thr Val Ala Pro Pro 
            20                  25                  30          


Lys Ala His Glu Val Arg Ile Lys Ile Leu Ala Ser Gly Ile Cys Gly 
        35                  40                  45              


Ser Asp Ser Ser Val Leu Lys Glu Ile Ile Pro Ser Lys Phe Pro Val 
    50                  55                  60                  


Ile Leu Gly His Glu Ala Val Gly Val Val Glu Ser Ile Gly Ala Gly 
65                  70                  75                  80  


Val Thr Cys Val Lys Pro Gly Asp Lys Val Ile Pro Leu Phe Val Pro 
                85                  90                  95      


Gln Cys Gly Ser Cys Arg Ala Cys Lys Ser Ser Asn Ser Asn Phe Cys 
            100                 105                 110         


Glu Lys Asn Asp Met Gly Ala Lys Thr Gly Leu Met Ala Asp Met Thr 
        115                 120                 125             


Ser Arg Phe Thr Cys Arg Gly Lys Pro Ile Tyr Asn Leu Val Gly Thr 
    130                 135                 140                 


Ser Thr Phe Thr Glu Tyr Thr Val Val Ala Asp Ile Ala Val Ala Lys 
145                 150                 155                 160 


Ile Asp Pro Lys Ala Pro Leu Glu Ser Cys Leu Ile Gly Cys Gly Phe 
                165                 170                 175     


Ala Thr Gly Tyr Gly Ala Ala Val Asn Thr Ala Lys Val Thr Pro Gly 
            180                 185                 190         


Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Phe Ser Ala Ile 
        195                 200                 205             


Val Gly Cys Lys Ala Ala Gly Ala Ser Arg Ile Ile Gly Val Gly Thr 
    210                 215                 220                 


His Lys Asp Lys Phe Pro Lys Ala Ile Glu Leu Gly Ala Thr Glu Cys 
225                 230                 235                 240 


Leu Asn Pro Lys Asp Tyr Asp Lys Pro Ile Tyr Glu Val Ile Cys Glu 
                245                 250                 255     


Lys Thr Asn Gly Gly Val Asp Tyr Ala Val Glu Cys Ala Gly Arg Ile 
            260                 265                 270         


Glu Thr Met Met Asn Ala Leu Gln Ser Thr Tyr Cys Gly Ser Gly Val 
        275                 280                 285             


Thr Val Val Leu Gly Leu Ala Ser Pro Asn Glu Arg Leu Pro Leu Asp 
    290                 295                 300                 


Pro Leu Leu Leu Leu Thr Gly Arg Ser Leu Lys Gly Ser Val Phe Gly 
305                 310                 315                 320 


Gly Phe Lys Gly Glu Glu Val Ser Arg Leu Val Asp Asp Tyr Met Lys 
                325                 330                 335     


Lys Lys Ile Asn Val Asn Phe Leu Val Ser Thr Lys Leu Thr Leu Asp 
            340                 345                 350         


Gln Ile Asn Lys Ala Phe Glu Leu Leu Ser Ser Gly Gln Gly Val Arg 
        355                 360                 365             


Ser Ile Met Ile Tyr 
    370             


<210>  29
<211>  351
<212>  PRT
<213>  Clostridium beijerinckii

<400>  29

Met Lys Gly Phe Ala Met Leu Gly Ile Asn Lys Leu Gly Trp Ile Glu 
1               5                   10                  15      


Lys Glu Arg Pro Val Ala Gly Ser Tyr Asp Ala Ile Val Arg Pro Leu 
            20                  25                  30          


Ala Val Ser Pro Cys Thr Ser Asp Ile His Thr Val Phe Glu Gly Ala 
        35                  40                  45              


Leu Gly Asp Arg Lys Asn Met Ile Leu Gly His Glu Ala Val Gly Glu 
    50                  55                  60                  


Val Val Glu Val Gly Ser Glu Val Lys Asp Phe Lys Pro Gly Asp Arg 
65                  70                  75                  80  


Val Ile Val Pro Cys Thr Thr Pro Asp Trp Arg Ser Leu Glu Val Gln 
                85                  90                  95      


Ala Gly Phe Gln Gln His Ser Asn Gly Met Leu Ala Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Phe Lys Asp Gly Val Phe Gly Glu Tyr Phe His Val Asn Asp 
        115                 120                 125             


Ala Asp Met Asn Leu Ala Ile Leu Pro Lys Asp Met Pro Leu Glu Asn 
    130                 135                 140                 


Ala Val Met Ile Thr Asp Met Met Thr Thr Gly Phe His Gly Ala Glu 
145                 150                 155                 160 


Leu Ala Asp Ile Gln Met Gly Ser Ser Val Val Val Ile Gly Ile Gly 
                165                 170                 175     


Ala Val Gly Leu Met Gly Ile Ala Gly Ala Lys Leu Arg Gly Ala Gly 
            180                 185                 190         


Arg Ile Ile Gly Val Gly Ser Arg Pro Ile Cys Val Glu Ala Ala Lys 
        195                 200                 205             


Phe Tyr Gly Ala Thr Asp Ile Leu Asn Tyr Lys Asn Gly His Ile Val 
    210                 215                 220                 


Asp Gln Val Met Lys Leu Thr Asn Gly Lys Gly Val Asp Arg Val Ile 
225                 230                 235                 240 


Met Ala Gly Gly Gly Ser Glu Thr Leu Ser Gln Ala Val Ser Met Val 
                245                 250                 255     


Lys Pro Gly Gly Ile Ile Ser Asn Ile Asn Tyr His Gly Ser Gly Asp 
            260                 265                 270         


Ala Leu Leu Ile Pro Arg Val Glu Trp Gly Cys Gly Met Ala His Lys 
        275                 280                 285             


Thr Ile Lys Gly Gly Leu Cys Pro Gly Gly Arg Leu Arg Ala Glu Met 
    290                 295                 300                 


Leu Arg Asp Met Val Val Tyr Asn Arg Val Asp Leu Ser Lys Leu Val 
305                 310                 315                 320 


Thr His Val Tyr His Gly Phe Asp His Ile Glu Glu Ala Leu Leu Leu 
                325                 330                 335     


Met Lys Asp Lys Pro Lys Asp Leu Ile Lys Ala Val Val Ile Leu 
            340                 345                 350     


<210>  30
<211>  360
<212>  PRT
<213>  Entamoeba histolytica

<400>  30

Met Lys Gly Leu Ala Met Leu Gly Ile Gly Arg Ile Gly Trp Ile Glu 
1               5                   10                  15      


Lys Lys Ile Pro Glu Cys Gly Pro Leu Asp Ala Leu Val Arg Pro Leu 
            20                  25                  30          


Ala Leu Ala Pro Cys Thr Ser Asp Thr His Thr Val Trp Ala Gly Ala 
        35                  40                  45              


Ile Gly Asp Arg His Asp Met Ile Leu Gly His Glu Ala Val Gly Gln 
    50                  55                  60                  


Ile Val Lys Val Gly Ser Leu Val Lys Arg Leu Lys Val Gly Asp Lys 
65                  70                  75                  80  


Val Ile Val Pro Ala Ile Thr Pro Asp Trp Gly Glu Glu Glu Ser Gln 
                85                  90                  95      


Arg Gly Tyr Pro Met His Ser Gly Gly Met Leu Gly Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Phe Lys Asp Gly Val Phe Ser Glu Val Phe His Val Asn Glu 
        115                 120                 125             


Ala Asp Ala Asn Leu Ala Leu Leu Pro Arg Asp Ile Lys Pro Glu Asp 
    130                 135                 140                 


Ala Val Met Leu Ser Asp Met Val Thr Thr Gly Phe His Gly Ala Glu 
145                 150                 155                 160 


Leu Ala Asn Ile Lys Leu Gly Asp Thr Val Cys Val Ile Gly Ile Gly 
                165                 170                 175     


Pro Val Gly Leu Met Ser Val Ala Gly Ala Asn His Leu Gly Ala Gly 
            180                 185                 190         


Arg Ile Phe Ala Val Gly Ser Arg Lys His Cys Cys Asp Ile Ala Leu 
        195                 200                 205             


Glu Tyr Gly Ala Thr Asp Ile Ile Asn Tyr Lys Asn Gly Asp Ile Val 
    210                 215                 220                 


Glu Gln Ile Leu Lys Ala Thr Asp Gly Lys Gly Val Asp Lys Val Val 
225                 230                 235                 240 


Ile Ala Gly Gly Asp Val His Thr Phe Ala Gln Ala Val Lys Met Ile 
                245                 250                 255     


Lys Pro Gly Ser Asp Ile Gly Asn Val Asn Tyr Leu Gly Glu Gly Asp 
            260                 265                 270         


Asn Ile Asp Ile Pro Arg Ser Glu Trp Gly Val Gly Met Gly His Lys 
        275                 280                 285             


His Ile His Gly Gly Leu Thr Pro Gly Gly Arg Val Arg Met Glu Lys 
    290                 295                 300                 


Leu Ala Ser Leu Ile Ser Thr Gly Lys Leu Asp Thr Ser Lys Leu Ile 
305                 310                 315                 320 


Thr His Arg Phe Glu Gly Leu Glu Lys Val Glu Asp Ala Leu Met Leu 
                325                 330                 335     


Met Lys Asn Lys Pro Ala Asp Leu Ile Lys Pro Val Val Arg Ile His 
            340                 345                 350         


Tyr Asp Asp Glu Asp Thr Leu His 
        355                 360 


<210>  31
<211>  347
<212>  PRT
<213>  Beijerickia indica

<400>  31

Met Lys Ala Leu Val Tyr Arg Gly Pro Gly Gln Lys Leu Val Glu Glu 
1               5                   10                  15      


Arg Gln Lys Pro Glu Leu Lys Glu Pro Gly Asp Ala Ile Val Lys Val 
            20                  25                  30          


Thr Lys Thr Thr Ile Cys Gly Thr Asp Leu His Ile Leu Lys Gly Asp 
        35                  40                  45              


Val Ala Thr Cys Lys Pro Gly Arg Val Leu Gly His Glu Gly Val Gly 
    50                  55                  60                  


Val Ile Glu Ser Val Gly Ser Gly Val Thr Ala Phe Gln Pro Gly Asp 
65                  70                  75                  80  


Arg Val Leu Ile Ser Cys Ile Ser Ser Cys Gly Lys Cys Ser Phe Cys 
                85                  90                  95      


Arg Arg Gly Met Phe Ser His Cys Thr Thr Gly Gly Trp Ile Leu Gly 
            100                 105                 110         


Asn Glu Ile Asp Gly Thr Gln Ala Glu Tyr Val Arg Val Pro His Ala 
        115                 120                 125             


Asp Thr Ser Leu Tyr Arg Ile Pro Ala Gly Ala Asp Glu Glu Ala Leu 
    130                 135                 140                 


Val Met Leu Ser Asp Ile Leu Pro Thr Gly Phe Glu Cys Gly Val Leu 
145                 150                 155                 160 


Asn Gly Lys Val Ala Pro Gly Ser Ser Val Ala Ile Val Gly Ala Gly 
                165                 170                 175     


Pro Val Gly Leu Ala Ala Leu Leu Thr Ala Gln Phe Tyr Ser Pro Ala 
            180                 185                 190         


Glu Ile Ile Met Ile Asp Leu Asp Asp Asn Arg Leu Gly Leu Ala Lys 
        195                 200                 205             


Gln Phe Gly Ala Thr Arg Thr Val Asn Ser Thr Gly Gly Asn Ala Ala 
    210                 215                 220                 


Ala Glu Val Lys Ala Leu Thr Glu Gly Leu Gly Val Asp Thr Ala Ile 
225                 230                 235                 240 


Glu Ala Val Gly Ile Pro Ala Thr Phe Glu Leu Cys Gln Asn Ile Val 
                245                 250                 255     


Ala Pro Gly Gly Thr Ile Ala Asn Val Gly Val His Gly Ser Lys Val 
            260                 265                 270         


Asp Leu His Leu Glu Ser Leu Trp Ser His Asn Val Thr Ile Thr Thr 
        275                 280                 285             


Arg Leu Val Asp Thr Ala Thr Thr Pro Met Leu Leu Lys Thr Val Gln 
    290                 295                 300                 


Ser His Lys Leu Asp Pro Ser Arg Leu Ile Thr His Arg Phe Ser Leu 
305                 310                 315                 320 


Asp Gln Ile Leu Asp Ala Tyr Glu Thr Phe Gly Gln Ala Ala Ser Thr 
                325                 330                 335     


Gln Ala Leu Lys Val Ile Ile Ser Met Glu Ala 
            340                 345         


<210>  32
<211>  376
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      


Glu Pro His Lys Pro Phe Thr Ile Glu Asp Ile Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala His Glu Val Arg Ile Lys Met Val Ala Thr Gly Val Cys Arg 
        35                  40                  45              


Ser Asp Asp His Ala Val Ser Gly Ser Leu Phe Thr Pro Leu Pro Ala 
    50                  55                  60                  


Val Leu Gly His Glu Gly Ala Gly Ile Val Glu Ser Ile Gly Glu Gly 
65                  70                  75                  80  


Val Thr Cys Val Lys Pro Gly Asp Lys Val Ile Pro Leu Phe Ser Pro 
                85                  90                  95      


Gln Cys Gly Lys Cys Arg Ile Cys Lys His Pro Glu Ser Asn Leu Cys 
            100                 105                 110         


Cys Gln Thr Lys Asn Leu Thr Gln Pro Lys Gly Ala Leu Leu Asp Gly 
        115                 120                 125             


Thr Ser Arg Phe Ser Cys Arg Gly Lys Pro Ile His His Phe Ile Ser 
    130                 135                 140                 


Thr Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Asp Ile Ala Val Ala 
145                 150                 155                 160 


Lys Ile Asp Ala Ala Ala Pro Leu Asp Lys Val Cys Leu Ile Gly Cys 
                165                 170                 175     


Gly Phe Ser Thr Gly Tyr Gly Ser Ala Val Gln Val Ala Lys Val Thr 
            180                 185                 190         


Pro Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser 
        195                 200                 205             


Val Val Ile Gly Cys Lys Thr Ala Gly Ala Ala Lys Ile Ile Ala Val 
    210                 215                 220                 


Asp Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Leu Gly Ala Thr 
225                 230                 235                 240 


Asp Cys Ile Asn Pro Gln Asp Tyr Thr Lys Pro Ile Gln Glu Val Leu 
                245                 250                 255     


Gln Glu Met Thr Asp Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly 
            260                 265                 270         


Arg Leu Asp Thr Met Thr Ser Ala Leu Leu Ser Cys His Ser Ala Cys 
        275                 280                 285             


Gly Val Ser Val Ile Val Gly Val Pro Pro Ser Ala Gln Ser Leu Ser 
    290                 295                 300                 


Val Asn Pro Met Ser Leu Leu Leu Gly Arg Thr Trp Lys Gly Ala Ile 
305                 310                 315                 320 


Phe Gly Gly Phe Lys Ser Lys Asp Ala Val Pro Lys Leu Val Ala Asp 
                325                 330                 335     


Phe Met Ala Lys Lys Phe Pro Leu Glu Pro Leu Ile Thr His Val Leu 
            340                 345                 350         


Pro Phe Glu Lys Ile Asn Glu Ala Phe Asp Leu Leu Arg Ala Gly Lys 
        355                 360                 365             


Ser Ile Arg Thr Val Leu Thr Phe 
    370                 375     


<210>  33
<211>  347
<212>  PRT
<213>  Thermus sp. ATN1

<400>  33

Met Arg Ala Val Val Phe Glu Asn Lys Glu Arg Val Ala Val Lys Glu 
1               5                   10                  15      


Val Asn Ala Pro Arg Leu Gln His Pro Leu Asp Ala Leu Val Arg Val 
            20                  25                  30          


His Leu Ala Gly Ile Cys Gly Ser Asp Leu His Leu Tyr His Gly Lys 
        35                  40                  45              


Ile Pro Val Leu Pro Gly Ser Val Leu Gly His Glu Phe Val Gly Gln 
    50                  55                  60                  


Val Glu Ala Val Gly Glu Gly Ile Gln Asp Leu Gln Pro Gly Asp Trp 
65                  70                  75                  80  


Val Val Gly Pro Phe His Ile Ala Cys Gly Thr Cys Pro Tyr Cys Arg 
                85                  90                  95      


Arg His Gln Tyr Asn Leu Cys Glu Arg Gly Gly Val Tyr Gly Tyr Gly 
            100                 105                 110         


Pro Met Phe Gly Asn Leu Gln Gly Ala Gln Ala Glu Ile Leu Arg Val 
        115                 120                 125             


Pro Phe Ser Asn Val Asn Leu Arg Lys Leu Pro Pro Asn Leu Ser Pro 
    130                 135                 140                 


Glu Arg Ala Ile Phe Ala Gly Asp Ile Leu Ser Thr Ala Tyr Gly Gly 
145                 150                 155                 160 


Leu Ile Gln Gly Gln Leu Arg Pro Gly Asp Ser Val Ala Val Ile Gly 
                165                 170                 175     


Ala Gly Pro Val Gly Leu Met Ala Ile Glu Val Ala Gln Val Leu Gly 
            180                 185                 190         


Ala Ser Lys Ile Leu Ala Ile Asp Arg Ile Pro Glu Arg Leu Glu Arg 
        195                 200                 205             


Ala Ala Ser Leu Gly Ala Ile Pro Ile Asn Ala Glu Gln Glu Asn Pro 
    210                 215                 220                 


Val Arg Arg Val Arg Ser Glu Thr Asn Asp Glu Gly Pro Asp Leu Val 
225                 230                 235                 240 


Leu Glu Ala Val Gly Gly Ala Ala Thr Leu Ser Leu Ala Leu Glu Met 
                245                 250                 255     


Val Arg Pro Gly Gly Arg Val Ser Ala Val Gly Val Asp Asn Ala Pro 
            260                 265                 270         


Ser Phe Pro Phe Pro Leu Ala Ser Gly Leu Val Lys Asp Leu Thr Phe 
        275                 280                 285             


Arg Ile Gly Leu Ala Asn Val His Leu Tyr Ile Asp Ala Val Leu Ala 
    290                 295                 300                 


Leu Leu Ala Ser Gly Arg Leu Gln Pro Glu Arg Ile Val Ser His Tyr 
305                 310                 315                 320 


Leu Pro Leu Glu Glu Ala Pro Arg Gly Tyr Glu Leu Phe Asp Arg Lys 
                325                 330                 335     


Glu Ala Leu Lys Val Leu Leu Val Val Arg Gly 
            340                 345         


<210>  34
<211>  345
<212>  PRT
<213>  Phenylobacterium zucineum HLK1

<400>  34

Met Lys Ala Leu Val Tyr Gly Gly Pro Gly Gln Lys Ser Leu Glu Asp 
1               5                   10                  15      


Arg Pro Lys Pro Glu Leu Gln Ala Pro Gly Asp Ala Ile Val Arg Ile 
            20                  25                  30          


Val Lys Thr Thr Ile Cys Gly Thr Asp Leu His Ile Leu Lys Gly Asp 
        35                  40                  45              


Val Ala Thr Cys Ala Pro Gly Arg Ile Leu Gly His Glu Gly Val Gly 
    50                  55                  60                  


Ile Val Asp Ser Val Gly Ala Ala Val Thr Ala Phe Arg Pro Gly Asp 
65                  70                  75                  80  


His Val Leu Ile Ser Cys Ile Ser Ala Cys Gly Lys Cys Asp Tyr Cys 
                85                  90                  95      


Arg Arg Gly Met Tyr Ser His Cys Thr Thr Gly Gly Trp Ile Leu Gly 
            100                 105                 110         


Asn Glu Ile Asp Gly Thr Gln Ala Glu Tyr Val Arg Thr Pro His Ala 
        115                 120                 125             


Asp Thr Ser Leu Tyr Pro Val Pro Ala Gly Ala Asp Glu Glu Ala Leu 
    130                 135                 140                 


Val Met Leu Ser Asp Ile Leu Pro Thr Gly Phe Glu Cys Gly Val Leu 
145                 150                 155                 160 


Asn Gly Lys Val Ala Pro Gly Gly Thr Val Ala Ile Val Gly Ala Gly 
                165                 170                 175     


Pro Ile Gly Leu Ala Ala Leu Leu Thr Ala Gln Phe Tyr Ser Pro Ala 
            180                 185                 190         


Glu Ile Ile Met Ile Asp Leu Asp Asp Asn Arg Leu Gly Ile Ala Arg 
        195                 200                 205             


Gln Phe Gly Ala Thr Gln Thr Ile Asn Ser Gly Asp Gly Arg Ala Ala 
    210                 215                 220                 


Glu Thr Val Lys Ala Leu Thr Gly Gly Arg Gly Val Asp Thr Ala Ile 
225                 230                 235                 240 


Glu Ala Val Gly Val Pro Ala Thr Phe Glu Leu Cys Gln Asp Leu Val 
                245                 250                 255     


Gly Pro Gly Gly Val Ile Ala Asn Ile Gly Val His Gly Arg Lys Val 
            260                 265                 270         


Asp Leu His Leu Asp Arg Leu Trp Ser Gln Asn Ile Ala Ile Thr Thr 
        275                 280                 285             


Arg Leu Val Asp Thr Val Ser Thr Pro Met Leu Leu Lys Thr Val Gln 
    290                 295                 300                 


Ser Arg Lys Leu Asp Pro Ser Gln Leu Ile Thr His Arg Phe Arg Leu 
305                 310                 315                 320 


Asp Glu Ile Leu Ala Ala Tyr Asp Thr Phe Ala Arg Ala Ala Asp Thr 
                325                 330                 335     


Gln Ala Leu Lys Val Ile Ile Ala Ala 
            340                 345 


<210>  35
<211>  345
<212>  PRT
<213>  Methyloceclla silvestris BL2

<400>  35

Met Lys Ala Leu Val Tyr His Gly Pro Gly Gln Lys Ala Leu Glu Glu 
1               5                   10                  15      


Arg Pro Lys Pro Gln Ile Glu Ala Ser Gly Asp Ala Ile Val Lys Ile 
            20                  25                  30          


Val Lys Thr Thr Ile Cys Gly Thr Asp Leu His Ile Leu Lys Gly Asp 
        35                  40                  45              


Val Ala Thr Cys Ala Pro Gly Arg Ile Leu Gly His Glu Gly Val Gly 
    50                  55                  60                  


Ile Ile Asp Ser Val Gly Ala Gly Val Thr Ala Phe Gln Pro Gly Asp 
65                  70                  75                  80  


Arg Val Leu Ile Ser Cys Ile Ser Ser Cys Gly Lys Cys Asp Tyr Cys 
                85                  90                  95      


Arg Arg Gly Leu Tyr Ser His Cys Thr Thr Gly Gly Trp Ile Leu Gly 
            100                 105                 110         


Asn Glu Ile Asp Gly Thr Gln Ala Glu Tyr Val Arg Thr Pro His Ala 
        115                 120                 125             


Asp Thr Ser Leu Tyr Arg Ile Pro Ala Gly Ala Asp Glu Glu Ala Leu 
    130                 135                 140                 


Val Met Leu Ser Asp Ile Leu Pro Thr Gly Phe Glu Cys Gly Val Leu 
145                 150                 155                 160 


Asn Gly Lys Val Glu Pro Gly Ser Thr Val Ala Ile Val Gly Ala Gly 
                165                 170                 175     


Pro Ile Gly Leu Ala Ala Leu Leu Thr Ala Gln Phe Tyr Ala Pro Gly 
            180                 185                 190         


Asp Ile Ile Met Ile Asp Leu Asp Asp Asn Arg Leu Asp Val Ala Arg 
        195                 200                 205             


Arg Phe Gly Ala Thr His Thr Ile Asn Ser Gly Asp Gly Lys Ala Ala 
    210                 215                 220                 


Glu Ala Val Lys Ala Leu Thr Gly Gly Ile Gly Val Asp Thr Ala Ile 
225                 230                 235                 240 


Glu Ala Val Gly Ile Pro Ala Thr Phe Leu Leu Cys Glu Asp Ile Val 
                245                 250                 255     


Ala Pro Gly Gly Val Ile Ala Asn Val Gly Val His Gly Val Lys Val 
            260                 265                 270         


Asp Leu His Leu Glu Arg Leu Trp Ala His Asn Ile Thr Ile Thr Thr 
        275                 280                 285             


Arg Leu Val Asp Thr Val Thr Thr Pro Met Leu Leu Lys Thr Val Gln 
    290                 295                 300                 


Ser Lys Lys Leu Asp Pro Leu Gln Leu Ile Thr His Arg Phe Thr Leu 
305                 310                 315                 320 


Asp His Ile Leu Asp Ala Tyr Asp Thr Phe Ser Arg Ala Ala Asp Thr 
                325                 330                 335     


Lys Ala Leu Lys Val Ile Val Ser Ala 
            340                 345 


<210>  36
<211>  360
<212>  PRT
<213>  Acinetobacter baumannii AYE

<400>  36

Met Glu Asn Ile Met Lys Ala Met Val Tyr Tyr Gly Asp His Asp Ile 
1               5                   10                  15      


Arg Phe Glu Glu Arg Lys Lys Pro Glu Leu Ile Asp Pro Thr Asp Ala 
            20                  25                  30          


Ile Ile Lys Met Thr Lys Thr Thr Ile Cys Gly Thr Asp Leu Gly Ile 
        35                  40                  45              


Tyr Lys Gly Lys Asn Pro Glu Ile Glu Gln Lys Glu Gln Glu Lys Asn 
    50                  55                  60                  


Gly Ser Phe Asn Gly Arg Ile Leu Gly His Glu Gly Ile Gly Ile Val 
65                  70                  75                  80  


Glu Gln Ile Gly Ser Ser Val Lys Asn Ile Lys Val Gly Asp Lys Val 
                85                  90                  95      


Ile Val Ser Cys Val Ser Arg Cys Gly Thr Cys Glu Asn Cys Ala Lys 
            100                 105                 110         


Gln Leu Tyr Ser His Cys Arg Asn Asp Gly Gly Trp Ile Met Gly Tyr 
        115                 120                 125             


Met Ile Asp Gly Thr Gln Ala Glu Tyr Val Arg Thr Pro Phe Ala Asp 
    130                 135                 140                 


Thr Ser Leu Tyr Val Leu Pro Glu Gly Leu Asn Glu Asp Val Ala Val 
145                 150                 155                 160 


Leu Leu Ser Asp Ala Leu Pro Thr Ala His Glu Ile Gly Val Gln Asn 
                165                 170                 175     


Gly Asp Ile Lys Pro Gly Asp Thr Val Ala Ile Val Gly Ala Gly Pro 
            180                 185                 190         


Val Gly Met Ser Ala Leu Leu Thr Ala Gln Phe Tyr Ser Pro Ser Gln 
        195                 200                 205             


Ile Ile Met Ile Asp Met Asp Glu Asn Arg Leu Ala Met Ala Lys Glu 
    210                 215                 220                 


Leu Gly Ala Thr Asp Thr Ile Asn Ser Gly Thr Glu Asp Ala Ile Ala 
225                 230                 235                 240 


Arg Val Met Glu Leu Thr Asn Gln Arg Gly Val Asp Cys Ala Ile Glu 
                245                 250                 255     


Ala Val Gly Ile Glu Pro Thr Trp Asp Ile Cys Gln Asn Ile Val Lys 
            260                 265                 270         


Glu Gly Gly His Leu Ala Asn Val Gly Val His Gly Lys Ser Val Asn 
        275                 280                 285             


Phe Ser Leu Glu Lys Leu Trp Ile Lys Asn Leu Thr Ile Thr Thr Gly 
    290                 295                 300                 


Leu Val Asn Ala Asn Thr Thr Gly Met Leu Leu Lys Ser Cys Cys Ser 
305                 310                 315                 320 


Gly Lys Leu Pro Met Glu Lys Leu Ala Thr His His Phe Lys Phe Asn 
                325                 330                 335     


Glu Ile Glu Lys Ala Tyr Asp Val Phe Ile Asn Ala Ala Lys Glu Lys 
            340                 345                 350         


Ala Met Lys Val Ile Ile Asp Phe 
        355                 360 


<210>  37
<211>  346
<212>  PRT
<213>  Geobacillus sp. WCH70

<400>  37

Met Lys Ala Leu Thr Tyr Leu Gly Pro Gly Lys Lys Glu Val Met Glu 
1               5                   10                  15      


Lys Pro Lys Pro Lys Ile Glu Lys Glu Thr Asp Ala Ile Val Lys Ile 
            20                  25                  30          


Thr Lys Thr Thr Ile Cys Gly Thr Asp Leu His Ile Leu Ser Gly Asp 
        35                  40                  45              


Val Pro Thr Val Glu Glu Gly Arg Ile Leu Gly His Glu Gly Val Gly 
    50                  55                  60                  


Ile Ile Glu Glu Val Gly Ser Gly Val Lys Asn Phe Lys Lys Gly Asp 
65                  70                  75                  80  


Arg Val Leu Ile Ser Cys Ile Thr Ser Cys Gly Lys Cys Glu Asn Cys 
                85                  90                  95      


Lys Lys Gly Leu Tyr Ala His Cys Glu Asp Gly Gly Trp Ile Leu Gly 
            100                 105                 110         


His Leu Ile Asp Gly Thr Gln Ala Glu Tyr Val Arg Ile Pro His Ala 
        115                 120                 125             


Asp Asn Ser Leu Tyr Pro Ile Pro Glu Gly Val Asp Glu Glu Ala Leu 
    130                 135                 140                 


Val Met Leu Ser Asp Ile Leu Pro Thr Gly Phe Glu Ile Gly Val Leu 
145                 150                 155                 160 


Asn Gly Lys Val Gln Pro Gly Gln Thr Val Ala Ile Ile Gly Ala Gly 
                165                 170                 175     


Pro Val Gly Met Ala Ala Leu Leu Thr Ala Gln Phe Tyr Ser Pro Ala 
            180                 185                 190         


Glu Ile Ile Met Val Asp Leu Asp Asp Asn Arg Leu Glu Val Ala Lys 
        195                 200                 205             


Lys Phe Gly Ala Thr Gln Val Val Asn Ser Ala Asp Gly Lys Ala Val 
    210                 215                 220                 


Glu Lys Ile Met Glu Leu Thr Gly Gly Lys Gly Val Asp Val Ala Met 
225                 230                 235                 240 


Glu Ala Val Gly Ile Pro Val Thr Phe Asp Ile Cys Gln Glu Ile Val 
                245                 250                 255     


Lys Pro Gly Gly Tyr Ile Ala Asn Ile Gly Val His Gly Lys Ser Val 
            260                 265                 270         


Glu Phe His Ile Glu Lys Leu Trp Ile Arg Asn Ile Thr Leu Thr Thr 
        275                 280                 285             


Gly Leu Val Asn Thr Thr Ser Thr Pro Met Leu Leu Lys Thr Val Gln 
    290                 295                 300                 


Ser Lys Lys Leu Lys Pro Glu Gln Leu Ile Thr His Arg Phe Ala Phe 
305                 310                 315                 320 


Ala Asp Ile Met Lys Ala Tyr Glu Val Phe Gly Asn Ala Ala Lys Glu 
                325                 330                 335     


Lys Ala Leu Lys Val Ile Ile Ser Asn Asp 
            340                 345     


<210>  38
<211>  360
<212>  PRT
<213>  Vanderwaltozyma polyspora DSM 70294

<400>  38

Met Ser Tyr Pro Glu Lys Phe Gln Gly Ile Gly Ile Thr Asn Arg Glu 
1               5                   10                  15      


Asp Trp Lys His Pro Lys Lys Val Thr Phe Glu Pro Lys Gln Phe Asn 
            20                  25                  30          


Asp Lys Asp Val Asp Ile Lys Ile Glu Ala Cys Gly Val Cys Gly Ser 
        35                  40                  45              


Asp Val His Cys Ala Ala Ser His Trp Gly Pro Val Ala Glu Lys Gln 
    50                  55                  60                  


Val Val Gly His Glu Ile Ile Gly Arg Val Leu Lys Val Gly Pro Lys 
65                  70                  75                  80  


Cys Thr Thr Gly Ile Lys Val Gly Asp Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Ala Trp Ser Cys Leu Glu Cys Ser Arg Cys Lys Ser Asp Asn Glu Ser 
            100                 105                 110         


Tyr Cys Pro Lys Ser Val Trp Thr Tyr Ser Ile Pro Tyr Ile Asp Gly 
        115                 120                 125             


Tyr Val Ser Gln Gly Gly Tyr Ala Ser His Ile Arg Leu His Glu His 
    130                 135                 140                 


Phe Ala Ile Pro Ile Pro Asp Lys Leu Ser Asn Glu Leu Ala Ala Pro 
145                 150                 155                 160 


Leu Leu Cys Gly Gly Ile Thr Val Tyr Ser Pro Leu Leu Arg Asn Gly 
                165                 170                 175     


Cys Gly Pro Gly Lys Lys Val Gly Ile Val Gly Ile Gly Gly Ile Gly 
            180                 185                 190         


His Met Gly Leu Leu Phe Ala Lys Gly Met Gly Ala Glu Val Tyr Ala 
        195                 200                 205             


Phe Ser Arg Thr His Ser Lys Glu Ala Asp Ala Lys Lys Leu Gly Ala 
    210                 215                 220                 


Asp His Phe Ile Ala Thr Leu Glu Asp Lys Asp Trp Thr Thr Lys Tyr 
225                 230                 235                 240 


Phe Asp Thr Leu Asp Leu Leu Val Ile Cys Ala Ser Ser Leu Thr Asp 
                245                 250                 255     


Ile Asn Phe Asp Glu Leu Thr Lys Ile Met Lys Val Asn Thr Lys Ile 
            260                 265                 270         


Ile Ser Ile Ser Ala Pro Ala Ala Asp Glu Val Leu Thr Leu Lys Pro 
        275                 280                 285             


Phe Gly Leu Ile Gly Val Thr Ile Gly Asn Ser Ala Ile Gly Ser Arg 
    290                 295                 300                 


Arg Glu Ile Glu His Leu Leu Asn Phe Val Ala Glu Lys Asp Ile Lys 
305                 310                 315                 320 


Pro Trp Val Glu Thr Leu Pro Val Gly Glu Ala Gly Val Asn Glu Ala 
                325                 330                 335     


Phe Glu Arg Met Asp Lys Gly Asp Val Lys Tyr Arg Phe Thr Leu Val 
            340                 345                 350         


Asp Phe Asp Lys Glu Phe Gly Asn 
        355                 360 


<210>  39
<211>  348
<212>  PRT
<213>  Mucor circinelloides

<400>  39

Met Ser Glu Glu Thr Phe Thr Ala Trp Ala Cys Lys Ser Lys Ser Ala 
1               5                   10                  15      


Pro Leu Glu Pro Met Glu Met Thr Phe Cys His Trp Asp Asp Asp Met 
            20                  25                  30          


Val Gln Met Asp Val Ile Cys Cys Gly Val Cys Gly Thr Asp Leu His 
        35                  40                  45              


Thr Val Asp Glu Gly Trp Gly Pro Thr Glu Phe Pro Cys Val Val Gly 
    50                  55                  60                  


His Glu Ile Ile Gly Asn Val Thr Lys Val Gly Lys Asn Val Thr Arg 
65                  70                  75                  80  


Ile Lys Val Gly Asp Arg Cys Gly Val Gly Cys Gln Ser Ala Ser Cys 
                85                  90                  95      


Gly Lys Cys Asp Phe Cys Lys Lys Gly Met Glu Asn Leu Cys Ser Thr 
            100                 105                 110         


His Ala Val Trp Thr Phe Asn Asp Arg Tyr Asp Asn Ala Thr Lys Asp 
        115                 120                 125             


Lys Thr Tyr Gly Gly Phe Ala Lys Lys Trp Arg Gly Asn Gln Asp Phe 
    130                 135                 140                 


Val Val His Val Pro Met Asp Phe Ser Pro Glu Val Ala Ala Ser Phe 
145                 150                 155                 160 


Leu Cys Gly Gly Val Thr Thr Tyr Ala Pro Leu Lys Arg Tyr Gly Val 
                165                 170                 175     


Gly Lys Gly Ser Lys Val Ala Val Leu Gly Leu Gly Gly Leu Gly His 
            180                 185                 190         


Phe Gly Val Gln Trp Ala Lys Ala Met Gly Ala Glu Val Val Ala Phe 
        195                 200                 205             


Asp Val Ile Pro Asp Lys Val Asp Asp Ala Lys Lys Leu Gly Cys Asp 
    210                 215                 220                 


Asp Tyr Val Leu Met Gln Lys Glu Glu Gln Met Glu Pro His Tyr Asn 
225                 230                 235                 240 


Thr Phe Thr His Ile Leu Ala Thr Lys Ile Val Asn Lys Cys Trp Asp 
                245                 250                 255     


Gln Tyr Phe Lys Met Leu Lys Asn Asn Gly Ile Phe Met Leu Cys Asp 
            260                 265                 270         


Ile Pro Glu Val Pro Leu Ser Gly Met Ser Ala Phe Val Met Ala Gly 
        275                 280                 285             


Lys Gln Leu Thr Ile Ala Gly Thr Phe Ile Gly Ser Pro Ser Val Ile 
    290                 295                 300                 


Gln Glu Cys Leu Asp Phe Ala Ala Lys His Asn Val Arg Thr Trp Val 
305                 310                 315                 320 


Asn Thr Phe Pro Met Glu Lys Ile Asn Glu Ala Phe Glu Phe Val Arg 
                325                 330                 335     


Gln Ala Lys Pro Arg Tyr Arg Ala Val Val Met Asn 
            340                 345             


<210>  40
<211>  350
<212>  PRT
<213>  Rhodococcus erythropolis PR4

<400>  40

Met Phe Thr Val Asn Ala Arg Ser Thr Ser Ala Pro Gly Ala Pro Phe 
1               5                   10                  15      


Glu Ala Val Val Ile Glu Arg Arg Asp Pro Gly Pro Gly Asp Val Val 
            20                  25                  30          


Ile Asp Ile Ala Phe Ser Gly Ile Cys His Thr Asp Val Ser Arg Ala 
        35                  40                  45              


Arg Ser Glu Phe Gly Thr Thr His Tyr Pro Leu Val Pro Gly His Glu 
    50                  55                  60                  


Ile Ala Gly Val Val Ser Lys Val Gly Ser Asp Val Thr Lys Phe Ala 
65                  70                  75                  80  


Val Gly Asp Arg Val Gly Val Gly Cys Ile Val Asp Ser Cys Arg Glu 
                85                  90                  95      


Cys Asp Tyr Cys Arg Ala Gly Leu Glu Pro Tyr Cys Arg Lys Asp His 
            100                 105                 110         


Val Arg Thr Tyr Asn Ser Met Gly Arg Asp Gly Arg Ile Thr Leu Gly 
        115                 120                 125             


Gly Tyr Ser Glu Lys Ile Val Val Asp Glu Gly Tyr Val Leu Arg Ile 
    130                 135                 140                 


Pro Asp Ala Ile Pro Leu Asp Gln Ala Ala Pro Leu Leu Cys Ala Gly 
145                 150                 155                 160 


Ile Thr Met Tyr Ser Pro Leu Arg His Trp Lys Ala Gly Pro Gly Ser 
                165                 170                 175     


Arg Ile Ala Ile Val Gly Phe Gly Gly Leu Gly His Val Gly Val Ala 
            180                 185                 190         


Ile Ala Arg Ala Leu Gly Ala His Thr Thr Val Phe Asp Leu Thr Met 
        195                 200                 205             


Asp Lys His Asp Asp Ala Ile Arg Leu Gly Ala Asp Asp Tyr Arg Leu 
    210                 215                 220                 


Ser Thr Asp Ala Gly Ile Phe Lys Glu Phe Glu Gly Ala Phe Glu Leu 
225                 230                 235                 240 


Ile Val Ser Thr Val Pro Ala Asn Leu Asp Tyr Asp Leu Phe Leu Lys 
                245                 250                 255     


Met Leu Ala Leu Asp Gly Thr Phe Val Gln Leu Gly Val Pro His Asn 
            260                 265                 270         


Pro Val Ser Leu Asp Val Phe Ser Leu Phe Tyr Asn Arg Arg Ser Leu 
        275                 280                 285             


Ala Gly Thr Leu Val Gly Gly Ile Gly Glu Thr Gln Glu Met Leu Asp 
    290                 295                 300                 


Phe Cys Ala Glu His Ser Ile Val Ala Glu Ile Glu Thr Val Gly Ala 
305                 310                 315                 320 


Asp Glu Ile Asp Ser Ala Tyr Asp Arg Val Ala Ala Gly Asp Val Arg 
                325                 330                 335     


Tyr Arg Met Val Leu Asp Val Gly Thr Leu Ala Thr Gln Arg 
            340                 345                 350 


<210>  41
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SadBXhoI-f primer

<400>  41
ccatggaatc tcgagatgaa agctctggtt tacc                                   34


<210>  42
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SadBKpnI-r primer

<400>  42
gatccccggg taccgagctc gaattc                                            26


<210>  43
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH6_XhoI_f primer

<400>  43
caagaaaact cgagatcatg tcttatcctg ag                                     32


<210>  44
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH6_KpnI_r primer

<400>  44
gagcttggta ccctagtctg aaaattcttt g                                      31


<210>  45
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH7_XhoI_f primer

<400>  45
ctgaaaaact cgagaaaaaa atgctttacc c                                      31


<210>  46
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH7_KpnI_r primer

<400>  46
gaaaaatatt aggtacctag actatttatg g                                      31


<210>  47
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1176 Primer

<400>  47
gcatagcaat ctaatctaag ttccagctga ggatgacaac agattactca tcaccagcat       60

at                                                                      62


<210>  48
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1177 Primer

<400>  48
atcaacacac aaacactaaa tcaaagctga ggatggattt atttgagtca ttagcacaaa       60

aa                                                                      62


<210>  49
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N822 Primer

<400>  49
cgcctcagct ttgatttagt gtttgtgtgt tgataagcag ttgc                        44


<210>  50
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1178 Primer

<400>  50
ggtatcgata agcttgatat cgaattcctg cgcccgggcc actagtcaga tgccgcgggc       60

act                                                                     63


<210>  51
<211>  10934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pRS423::TEF(M4)-xpk1+ENO1-eutD plasmid

<400>  51
ggtggagctc cagcttttgt tccctttagt gagggttaat tgcgcgcttg gcgtaatcat       60

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacataggag      120

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gaggtaactc acattaattg      180

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa      240

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca      300

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg      360

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc      420

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc      480

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac      540

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc      600

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata      660

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc      720

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca      780

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag      840

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta      900

gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg      960

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     1020

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     1080

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     1140

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     1200

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     1260

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     1320

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     1380

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     1440

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     1500

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     1560

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     1620

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     1680

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     1740

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     1800

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     1860

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     1920

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     1980

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     2040

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     2100

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     2160

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgaacgaa     2220

gcatctgtgc ttcattttgt agaacaaaaa tgcaacgcga gagcgctaat ttttcaaaca     2280

aagaatctga gctgcatttt tacagaacag aaatgcaacg cgaaagcgct attttaccaa     2340

cgaagaatct gtgcttcatt tttgtaaaac aaaaatgcaa cgcgagagcg ctaatttttc     2400

aaacaaagaa tctgagctgc atttttacag aacagaaatg caacgcgaga gcgctatttt     2460

accaacaaag aatctatact tcttttttgt tctacaaaaa tgcatcccga gagcgctatt     2520

tttctaacaa agcatcttag attacttttt ttctcctttg tgcgctctat aatgcagtct     2580

cttgataact ttttgcactg taggtccgtt aaggttagaa gaaggctact ttggtgtcta     2640

ttttctcttc cataaaaaaa gcctgactcc acttcccgcg tttactgatt actagcgaag     2700

ctgcgggtgc attttttcaa gataaaggca tccccgatta tattctatac cgatgtggat     2760

tgcgcatact ttgtgaacag aaagtgatag cgttgatgat tcttcattgg tcagaaaatt     2820

atgaacggtt tcttctattt tgtctctata tactacgtat aggaaatgtt tacattttcg     2880

tattgttttc gattcactct atgaatagtt cttactacaa tttttttgtc taaagagtaa     2940

tactagagat aaacataaaa aatgtagagg tcgagtttag atgcaagttc aaggagcgaa     3000

aggtggatgg gtaggttata tagggatata gcacagagat atatagcaaa gagatacttt     3060

tgagcaatgt ttgtggaagc ggtattcgca atattttagt agctcgttac agtccggtgc     3120

gtttttggtt ttttgaaagt gcgtcttcag agcgcttttg gttttcaaaa gcgctctgaa     3180

gttcctatac tttctagaga ataggaactt cggaatagga acttcaaagc gtttccgaaa     3240

acgagcgctt ccgaaaatgc aacgcgagct gcgcacatac agctcactgt tcacgtcgca     3300

cctatatctg cgtgttgcct gtatatatat atacatgaga agaacggcat agtgcgtgtt     3360

tatgcttaaa tgcgtactta tatgcgtcta tttatgtagg atgaaaggta gtctagtacc     3420

tcctgtgata ttatcccatt ccatgcgggg tatcgtatgc ttccttcagc actacccttt     3480

agctgttcta tatgctgcca ctcctcaatt ggattagtct catccttcaa tgctatcatt     3540

tcctttgata ttggatcatc taagaaacca ttattatcat gacattaacc tataaaaata     3600

ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac     3660

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag     3720

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat     3780

cagagcagat tgtactgaga gtgcaccata aattcccgtt ttaagagctt ggtgagcgct     3840

aggagtcact gccaggtatc gtttgaacac ggcattagtc agggaagtca taacacagtc     3900

ctttcccgca attttctttt tctattactc ttggcctcct ctagtacact ctatattttt     3960

ttatgcctcg gtaatgattt tcattttttt ttttccccta gcggatgact cttttttttt     4020

cttagcgatt ggcattatca cataatgaat tatacattat ataaagtaat gtgatttctt     4080

cgaagaatat actaaaaaat gagcaggcaa gataaacgaa ggcaaagatg acagagcaga     4140

aagccctagt aaagcgtatt acaaatgaaa ccaagattca gattgcgatc tctttaaagg     4200

gtggtcccct agcgatagag cactcgatct tcccagaaaa agaggcagaa gcagtagcag     4260

aacaggccac acaatcgcaa gtgattaacg tccacacagg tatagggttt ctggaccata     4320

tgatacatgc tctggccaag cattccggct ggtcgctaat cgttgagtgc attggtgact     4380

tacacataga cgaccatcac accactgaag actgcgggat tgctctcggt caagctttta     4440

aagaggccct actggcgcgt ggagtaaaaa ggtttggatc aggatttgcg cctttggatg     4500

aggcactttc cagagcggtg gtagatcttt cgaacaggcc gtacgcagtt gtcgaacttg     4560

gtttgcaaag ggagaaagta ggagatctct cttgcgagat gatcccgcat tttcttgaaa     4620

gctttgcaga ggctagcaga attaccctcc acgttgattg tctgcgaggc aagaatgatc     4680

atcaccgtag tgagagtgcg ttcaaggctc ttgcggttgc cataagagaa gccacctcgc     4740

ccaatggtac caacgatgtt ccctccacca aaggtgttct tatgtagtga caccgattat     4800

ttaaagctgc agcatacgat atatatacat gtgtatatat gtatacctat gaatgtcagt     4860

aagtatgtat acgaacagta tgatactgaa gatgacaagg taatgcatca ttctatacgt     4920

gtcattctga acgaggcgcg ctttcctttt ttctttttgc tttttctttt tttttctctt     4980

gaactcgacg gatctatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc     5040

atcaggaaat tgtaaacgtt aatattttgt taaaattcgc gttaaatttt tgttaaatca     5100

gctcattttt taaccaatag gccgaaatcg gcaaaatccc ttataaatca aaagaataga     5160

ccgagatagg gttgagtgtt gttccagttt ggaacaagag tccactatta aagaacgtgg     5220

actccaacgt caaagggcga aaaaccgtct atcagggcga tggcccacta cgtgaaccat     5280

caccctaatc aagttttttg gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag     5340

ggagcccccg atttagagct tgacggggaa agccggcgaa cgtggcgaga aaggaaggga     5400

agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa     5460

ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc gtcgcgccat tcgccattca     5520

ggctgcgcaa ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta cgccagctgg     5580

cgaaaggggg atgtgctgca aggcgattaa gttgggtaac gccagggttt tcccagtcac     5640

gacgttgtaa aacgacggcc agtgagcgcg cgtaatacga ctcactatag ggcgaattgg     5700

gtaccgggcc ccccctcgag gtcgacggta tcgataagct tgatatcgaa ttcctgcgcc     5760

cgggccacta gtcagatgcc gcgggcactt gagcacctca tgcacagcaa taacacaaca     5820

caatggttag tagcaacctg aattcggtca ttgatgcatg catgtgccgt gaagcgggac     5880

aaccagaaaa gtcgtctata aatgccggca cgtgcgatca tcgtggcggg gttttaagag     5940

tgcatatcac aaattgtcgc attaccgcgg aaccgccaga tattcattac ttgacgcaaa     6000

agcgtttgaa ataatgacga aaaagaagga agaaaaaaaa agaaaaatac cgcttctagg     6060

cgggttatct actgatccga gcttccacta ggatagcacc caaacacctg catatttgga     6120

cgacctttac ttacaccacc aaaaaccact ttcgcctctc ccgcccctga taacgtccac     6180

taattgagcg attacctgag cggtcctctt ttgtttgcag catgagactt gcatactgca     6240

aatcgtaagt agcaacgtct caaggtcaaa actgtatgga aaccttgtca cctcacttaa     6300

ttctagctag cctaccctgc aagtcaagag gtctccgtga ttcctagcca cctcaaggta     6360

tgcctctccc cggaaactgt ggccttttct ggcacacatg atctccacga tttcaacata     6420

taaatagctt ttgataatgg caatattaat caaatttatt ttacttcttt cttgtaacat     6480

ctctcttgta atcccttatt ccttctagct atttttcata aaaaaccaag caactgctta     6540

tcaacacaca aacactaaat caaagctgag gatggattta tttgagtcat tagcacaaaa     6600

aattactggt aaagatcaaa caattgtttt ccctgaagga actgaacccc gaattgtcgg     6660

tgcggcagcg cgattagctg cagacggctt ggttaagccg attgttttag gtgcaacgga     6720

caaagttcag gctgtggcta acgatttgaa tgcggattta acaggcgttc aagtccttga     6780

tcctgcgaca tacccggctg aagataagca agcaatgctt gatgccctcg ttgaacggcg     6840

gaaaggtaag aatacgccag aacaagcggc taaaatgctg gaagatgaaa actactttgg     6900

cacgatgctc gtttatatgg gcaaagcgga tgggatggtt tcaggtgcaa tccatccaac     6960

tggtgatacg gtacggccag cgttacaaat tattaagacc aagcccggtt cacaccgaat     7020

ctcgggtgca tttatcatgc aaaagggtga ggaacgctac gtctttgctg actgtgccat     7080

caatattgat cccgatgccg atacgttagc ggaaattgcc actcagagtg cggctactgc     7140

taaggtcttc gatattgacc cgaaagttgc gatgctcagc ttctcaacta agggttcggc     7200

taagggtgaa atggtcacta aagtgcaaga agcaacggcc aaggcgcaag ctgctgaacc     7260

ggaattggct atcgatggtg aacttcaatt tgacgcggcc ttcgttgaaa aagttggttt     7320

gcaaaaggct cctggttcca aagtagctgg tcatgccaat gtctttgtat ttccagagct     7380

tcagtctggt aatattggct ataagattgc gcaacgattt ggtcattttg aagcggtggg     7440

tcctgtcttg caaggcctga acaagccggt ctccgacttg tcacgtggat gcagtgaaga     7500

agacgtttat aaggttgcga ttattacagc agcccaagga ttagcttaat taattaagag     7560

taagcgaatt tcttatgatt tatgattttt attattaaat aagttataaa aaaaataagt     7620

gtatacaaat tttaaagtga ctcttaggtt ttaaaacgaa aattcttatt cttgagtaac     7680

tctttcctgt aggtcaggtt gctttctcag gtatagcatg aggtcgctct tattgaccac     7740

acctctaccg gcatgccgag caaatgcctg caaatcgctc cccatttcac ccaattgtag     7800

atatgctaac tccagcaatg agttgatgaa tctcggtgtg tattttatgt cctcagagga     7860

caacacctgt ggtactagtt ctagagcggc cgcccgcaaa ttaaagcctt cgagcgtccc     7920

aaaaccttct caagcaaggt tttcagtata atgttacatg cgtacacgcg tttgtacaga     7980

aaaaaaagaa aaatttgaaa tataaataac gttcttaata ctaacataac tattaaaaaa     8040

aataaatagg gacctagact tcaggttgtc taactccttc cttttcggtt agagcggatg     8100

tgggaggagg gcgtgaatgt aagcgtgaca taactaatta catgattaat taattatttt     8160

aaacccttcc attgccaatc attaacttct ggcaagtcag ttccggcatc ccggatatag     8220

gcattgtgtt tagcaagcat attatccatg gattgaacga aggccgcacc agtgttttcc     8280

attgctggtt gcgccgcaat tgccgactta gctaagtcga agcggtccat ctggttcatg     8340

acccgtacgt cgaatggtgt ggtaatatca ccattttcac ggtaaccgtg gacgtataag     8400

ttatggttgt gacgatcaaa gaagatgtca cgaactaagt cttcgtaacc gtggaaagca     8460

aagaccactg gtttgtcctt agtaaagtaa tggtcaaact cagcatctga caagccccgc     8520

ggatcctttt caggactacg taacttcaag atgtcgacca cgttcacgaa acgaatcttc     8580

atctctggga aactgtcgtg tagtaattgg atggcagcca acgtttcaag cgttggttcc     8640

gtcccagcag ctgcaaagac aatgtctggt tcgctacctt ggtccgtact tgcccaatca     8700

atgataccaa gaccattgtc aactaattgc ttagcttctt caatgctgaa ccattgttga     8760

cgtgggtgtt ttgacgtaac cacgtagttg atcttttctt ggctccggaa aatgacgtca     8820

ccgacagcta ataacgtgtt ggcatcggct ggtaaatatt cacgaatgta ttctggtttc     8880

ttttcggcca aatgagttaa tgcacctgga tcttggtggg tataaccatt atggtcttgt     8940

tggaatacag ttgaagccgc gataatgtta agtgatgggt actttttacg ccaatcaagt     9000

tcattggctt tacgtaacca cttgaagtgt tgcgtcaaca ttgagtccac aacgcgtagg     9060

aaggcttcat aactggcaaa taacccatga cgtccagtta agacgtaacc ttctaaccaa     9120

ccttcagctt ggtgttcaga taactgagca tctaagaccc ggccagctgg tgcttcatat     9180

tggtcactat ctggatgaat gtcttccatc cattgacgat tagtggtttc gaagacacca     9240

tataaacggt tagacatggt ttcatcaggt ccgaacaacc ggaagttatc aggatttttc     9300

ttgatgacat cccgcaaata gtctgaccaa acgatcatat cttgcttaac attcgcgcct     9360

tctttggacg tatcgaccgc ataatcacgg aagtttggta agttcaaggc tttcggatcg     9420

accccaccat tggtgattgg gttagcagcc atccgactgt ccccagtagg aataatttct     9480

ttaatatcat ccttcaaaga gccatcttca ttgaagagtt cttttggttg atatgattcg     9540

agccaatcaa ctaaagcatc cgcatgttcc atgtcatttt gatcaacagg aatcggaatt     9600

tgatgagcac ggaatgaacc ttcgatctta tcaccgtccc atgacttcgg accagtccag     9660

cccttaggtg cgcggaagac gatcattggc catactggca atgttgcatc gttattttcg     9720

cgagcatgct tctggattgc cttgatcttt tcaacggctt catccatggc cttagctaag     9780

gctgggtgaa ccttttcagg atcgtcacct tcaacgaaga ttggttccca attcatgctt     9840

tcgaagtatt ccttaatctt agcatcagaa gtccgaccaa aaatcgttgg attagaaatc     9900

ttaaaaccat ttaagttcaa gattggtaaa acagccccgt cgttgattgg gttaatgaac     9960

ttcgttgatt gccatgaagt tgctaatgga cccgtttcgg attccccatc accaacaaca    10020

accgcggcga tttcgtcagg attgtcaaga attgccccaa ccccgtgtga aattgagtaa    10080

ccaagttcgc caccttcgtg gattgaaccg ggtgtttcag gtgccgcatg ggaagcaacc    10140

ccacctggga atgagaattg cttgaagagc ttttgcatcc cttcaacatc ctgcgtaatt    10200

tctggataaa tatcggtgta agtaccgtca aggtaagagt ttgaaaccat cacttgacca    10260

ccatgacctg gaccttcaac gtagaacatc ttcaaaccgt acttgttgat gacccggtta    10320

agatgagcat agataaagtt ttgaccggca atcgtccccc agtgaccaat tggatgaacc    10380

ttaacgtcac tggccttcaa tggccgttgt aatagtggat tatcttttaa ataaagttga    10440

ccaactgata agtagttggc agcacgccag tacttatcaa ctttttgcaa atatgctggt    10500

gatgagtaat ctgttgtcat cctcagctgg aacttagatt agattgctat gctttctctc    10560

taacgagcaa gaagtaaaaa aagttgtaat agaacaagaa aaatgaaact gaagcttgag    10620

aaattgaaga ccgtttatta gcttaaatat caatgggagg tcatcgaaag agaaaaaaat    10680

caagaaagaa actctcaaga aaaagaaacg tgataaaaat ttttattgcc tctctcgacg    10740

aagagaaaga aacgaggcgg tccctttttt cttttccaaa cctttagtac gggtaattag    10800

cgacacccta gaggaagaaa gaggggaaat ttagtatgct gtgcttgggt gtcttgaagt    10860

ggtacggcga tgcgcggagt ccgagaaaat ctggaagagt aaaaaggggg tagaagcgtt    10920

ttgaagctat ccgc                                                      10934


<210>  52
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N821 Primer

<400>  52
cgcccgggcc actagtcaga tgccgcgggc acttgagc                               38


<210>  53
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1115 Primer

<400>  53
tttttgtgct aatgactcaa ataaatccat                                        30


<210>  54
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1110 Primer

<400>  54
gcgatttaat ctctaattat tagttaaagt                                        30


<210>  55
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1114 Primer

<400>  55
atatgctggt gatgagtaat ctgttgtcat                                        30


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N160SeqF5 Primer

<400>  56
cctgaagtct aggtccctat tt                                                22


<210>  57
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BK468 Primer

<400>  57
gcctcgagtt ttaatgttac ttctcttgca gttaggga                               38


<210>  58
<211>  9220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUC19-URA3::pdc1::TEF(M4)-xpk1::kan Plasmid

<400>  58
ccgcattgcg gattacgtat tctaatgttc agataacttc gtataatgta tgctatacga       60

agttatcgaa cagagaaact aaatccacat taattgagag ttctatctat tagaaaatgc      120

aaactccaac taaatgggaa aacagataac ctcttttatt tttttttaat gtttgatatt      180

cgagtctttt tcttttgtta ggtttatatt catcatttca atgaataaaa gaagcttctt      240

attttggttg caaagaatga aaaaaaagga ttttttcata cttctaaagc ttcaattata      300

accaaaaatt ttataaatga agagaaaaaa tctagtagta tcaagttaaa cttagaaaaa      360

ctcatcgagc atcaaatgaa actgcaattt attcatatca ggattatcaa taccatattt      420

ttgaaaaagc cgtttctgta atgaaggaga aaactcaccg aggcagttcc ataggatggc      480

aagatcctgg tatcggtctg cgattccgac tcgtccaaca tcaatacaac ctattaattt      540

cccctcgtca aaaataaggt tatcaagtga gaaatcacca tgagtgacga ctgaatccgg      600

tgagaatggc aaaagcttat gcatttcttt ccagacttgt tcaacaggcc agccattacg      660

ctcgtcatca aaatcactcg catcaaccaa accgttattc attcgtgatt gcgcctgagc      720

gagacgaaat acgcgatcgc tgttaaaagg acaattacaa acaggaatcg aatgcaaccg      780

gcgcaggaac actgccagcg catcaacaat attttcacct gaatcaggat attcttctaa      840

tacctggaat gctgttttgc cggggatcgc agtggtgagt aaccatgcat catcaggagt      900

acggataaaa tgcttgatgg tcggaagagg cataaattcc gtcagccagt ttagtctgac      960

catctcatct gtaacatcat tggcaacgct acctttgcca tgtttcagaa acaactctgg     1020

cgcatcgggc ttcccataca atcgatagat tgtcgcacct gattgcccga cattatcgcg     1080

agcccattta tacccatata aatcagcatc catgttggaa tttaatcgcg gcctcgaaac     1140

gtgagtcttt tccttaccca tctcgagttt taatgttact tctcttgcag ttagggaact     1200

ataatgtaac tcaaaataag attaaacaaa ctaaaataaa aagaagttat acagaaaaac     1260

ccatataaac cagtactaat ccataataat aatacacaaa aaaactatca aataaaacca     1320

gaaaacagat tgaatagaaa aattttttcg atctcctttt atattcaaaa ttcgatatat     1380

gaaaaaggga actctcagaa aatcaccaaa tcaatttaat tagatttttc ttttccttct     1440

agcgttggaa agaaaaattt ttcttttttt ttttagaaat gaaaaatttt tgccgtagga     1500

atcaccgtat aaaccctgta taaacgctac tctgttcacc tgtgtaggct atgattgacc     1560

cagtgttcat tgttattgcg agagagcggg agaaaagaac cgatacaaga gatccatgct     1620

ggtatagttg tctgtccaac actttgatga acttgtagga cgatgatgtg tatttagacg     1680

agtacgtgtg tgactattaa gtagttatga tagagaggtt tgtacggtgt gttctgtgta     1740

attcgattga gaaaatggtt atgaatccct agataacttc gtataatgta tgctatacga     1800

agttatccag tgatgataca acgagttagc caaggtgggg gatcctctag agtcttaagg     1860

ccgcccgcaa attaaagcct tcgagcgtcc caaaaccttc tcaagcaagg ttttcagtat     1920

aatgttacat gcgtacacgc gtttgtacag aaaaaaaaga aaaatttgaa atataaataa     1980

cgttcttaat actaacataa ctattaaaaa aaataaatag ggacctagac ttcaggttgt     2040

ctaactcctt ccttttcggt tagagcggat gtgggaggag ggcgtgaatg taagcgtgac     2100

ataactaatt acatgattaa ttaattattt taaacccttc cattgccaat cattaacttc     2160

tggcaagtca gttccggcat cccggatata ggcattgtgt ttagcaagca tattatccat     2220

ggattgaacg aaggccgcac cagtgttttc cattgctggt tgcgccgcaa ttgccgactt     2280

agctaagtcg aagcggtcca tctggttcat gacccgtacg tcgaatggtg tggtaatatc     2340

accattttca cggtaaccgt ggacgtataa gttatggttg tgacgatcaa agaagatgtc     2400

acgaactaag tcttcgtaac cgtggaaagc aaagaccact ggtttgtcct tagtaaagta     2460

atggtcaaac tcagcatctg acaagccccg cggatccttt tcaggactac gtaacttcaa     2520

gatgtcgacc acgttcacga aacgaatctt catctctggg aaactgtcgt gtagtaattg     2580

gatggcagcc aacgtttcaa gcgttggttc cgtcccagca gctgcaaaga caatgtctgg     2640

ttcgctacct tggtccgtac ttgcccaatc aatgatacca agaccattgt caactaattg     2700

cttagcttct tcaatgctga accattgttg acgtgggtgt tttgacgtaa ccacgtagtt     2760

gatcttttct tggctccgga aaatgacgtc accgacagct aataacgtgt tggcatcggc     2820

tggtaaatat tcacgaatgt attctggttt cttttcggcc aaatgagtta atgcacctgg     2880

atcttggtgg gtataaccat tatggtcttg ttggaataca gttgaagccg cgataatgtt     2940

aagtgatggg tactttttac gccaatcaag ttcattggct ttacgtaacc acttgaagtg     3000

ttgcgtcaac attgagtcca caacgcgtag gaaggcttca taactggcaa ataacccatg     3060

acgtccagtt aagacgtaac cttctaacca accttcagct tggtgttcag ataactgagc     3120

atctaagacc cggccagctg gtgcttcata ttggtcacta tctggatgaa tgtcttccat     3180

ccattgacga ttagtggttt cgaagacacc atataaacgg ttagacatgg tttcatcagg     3240

tccgaacaac cggaagttat caggattttt cttgatgaca tcccgcaaat agtctgacca     3300

aacgatcata tcttgcttaa cattcgcgcc ttctttggac gtatcgaccg cataatcacg     3360

gaagtttggt aagttcaagg ctttcggatc gaccccacca ttggtgattg ggttagcagc     3420

catccgactg tccccagtag gaataatttc tttaatatca tccttcaaag agccatcttc     3480

attgaagagt tcttttggtt gatatgattc gagccaatca actaaagcat ccgcatgttc     3540

catgtcattt tgatcaacag gaatcggaat ttgatgagca cggaatgaac cttcgatctt     3600

atcaccgtcc catgacttcg gaccagtcca gcccttaggt gcgcggaaga cgatcattgg     3660

ccatactggc aatgttgcat cgttattttc gcgagcatgc ttctggattg ccttgatctt     3720

ttcaacggct tcatccatgg ccttagctaa ggctgggtga accttttcag gatcgtcacc     3780

ttcaacgaag attggttccc aattcatgct ttcgaagtat tccttaatct tagcatcaga     3840

agtccgacca aaaatcgttg gattagaaat cttaaaacca tttaagttca agattggtaa     3900

aacagccccg tcgttgattg ggttaatgaa cttcgttgat tgccatgaag ttgctaatgg     3960

acccgtttcg gattccccat caccaacaac aaccgcggcg atttcgtcag gattgtcaag     4020

aattgcccca accccgtgtg aaattgagta accaagttcg ccaccttcgt ggattgaacc     4080

gggtgtttca ggtgccgcat gggaagcaac cccacctggg aatgagaatt gcttgaagag     4140

cttttgcatc ccttcaacat cctgcgtaat ttctggataa atatcggtgt aagtaccgtc     4200

aaggtaagag tttgaaacca tcacttgacc accatgacct ggaccttcaa cgtagaacat     4260

cttcaaaccg tacttgttga tgacccggtt aagatgagca tagataaagt tttgaccggc     4320

aatcgtcccc cagtgaccaa ttggatgaac cttaacgtca ctggccttca atggccgttg     4380

taatagtgga ttatctttta aataaagttg accaactgat aagtagttgg cagcacgcca     4440

gtacttatca actttttgca aatatgctgg tgatgagtaa tctgttgtca tcctcagctg     4500

gaacttagat tagattgcta tgctttctct ctaacgagca agaagtaaaa aaagttgtaa     4560

tagaacaaga aaaatgaaac tgaagcttga gaaattgaag accgtttatt agcttaaata     4620

tcaatgggag gtcatcgaaa gagaaaaaaa tcaagaaaga aactctcaag aaaaagaaac     4680

gtgataaaaa tttttattgc ctctctcgac gaagagaaag aaacgaggcg gtcccttttt     4740

tcttttccaa acctttagta cgggtaatta gcgacaccct agaggaagaa agaggggaaa     4800

tttagtatgc tgtgcttggg tgtcttgaag tggtacggcg atgcgcggag tccgagaaaa     4860

tctggaagag taaaaagggg gtagaagcgt tttgaagcta tccgcggtgg ttaagcctaa     4920

ccaggccaat tcaacagact gtcggcaact tcttgtctgg tctttccatg gtaagtgaca     4980

gtgcagtaat aatatgaacc aatttatttt tcgttacata aaaatgctta taaaacttta     5040

actaataatt agagattaaa tcgcaaacgg ccggccaatg tggctgtggt ttcagggtcc     5100

ataaagcttt tcaattcatc tttttttttt ttgttctttt ttttgattcc ggtttctttg     5160

aaattttttt gattcggtaa tctccgagca gaaggaagaa cgaaggaagg agcacagact     5220

tagattggta tatatacgca tatgtggtgt tgaagaaaca tgaaattgcc cagtattctt     5280

aacccaactg cacagaacaa aaacctgcag gaaacgaaga taaatcatgt cgaaagctac     5340

atataaggaa cgtgctgcta ctcatcctag tcctgttgct gccaagctat ttaatatcat     5400

gcacgaaaag caaacaaact tgtgtgcttc attggatgtt cgtaccacca aggaattact     5460

ggagttagtt gaagcattag gtcccaaaat ttgtttacta aaaacacatg tggatatctt     5520

gactgatttt tccatggagg gcacagttaa gccgctaaag gcattatccg ccaagtacaa     5580

ttttttactc ttcgaagaca gaaaatttgc tgacattggt aatacagtca aattgcagta     5640

ctctgcgggt gtatacagaa tagcagaatg ggcagacatt acgaatgcac acggtgtggt     5700

gggcccaggt attgttagcg gtttgaagca ggcggcggaa gaagtaacaa aggaacctag     5760

aggccttttg atgttagcag aattgtcatg caagggctcc ctagctactg gagaatatac     5820

taagggtact gttgacattg cgaagagcga caaagatttt gttatcggct ttattgctca     5880

aagagacatg ggtggaagag atgaaggtta cgattggttg attatgacac ccggtgtggg     5940

tttagatgac aagggagacg cattgggtca acagtataga accgtggatg atgtggtctc     6000

tacaggatct gacattatta ttgttggaag aggactattt gcaaagggaa gggatgctaa     6060

ggtagagggt gaacgttaca gaaaagcagg ctgggaagca tatttgagaa gatgcggcca     6120

gcaaaactaa aaaactgtat tataagtaaa tgcatgtata ctaaactcac aaattagagc     6180

ttcaatttaa ttatatcagt tattacccgg gaatctcggt cgtaatgatt tctataatga     6240

cgaaaaaaaa aaaattggaa agaaaaagct tcatggcctt gcggccgctt aattaatcta     6300

gagtcgacct gcaggcatgc aagcttggcg taatcatggt catagctgtt tcctgtgtga     6360

aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc     6420

tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc     6480

cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc     6540

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     6600

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     6660

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     6720

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     6780

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     6840

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     6900

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     6960

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     7020

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     7080

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     7140

gagttcttga agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc     7200

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     7260

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     7320

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     7380

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta     7440

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt     7500

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata     7560

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc     7620

agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac     7680

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag     7740

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac     7800

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc     7860

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg     7920

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc     7980

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct     8040

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc     8100

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc     8160

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc     8220

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc     8280

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca     8340

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt     8400

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt     8460

ccgcgcacat ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca     8520

ttaacctata aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac     8580

ggtgaaaacc tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat     8640

gccgggagca gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg     8700

cttaactatg cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata     8760

ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc attcgccatt caggctgcgc     8820

aactgttggg aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg     8880

ggatgtgctg caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt     8940

aaaacgacgg ccagtgaatt cgagctcggt acccggggat ccggcgcgcc gttttatttg     9000

tatcgaggtg tctagtcttc tattacacta atgcagtttc agggttttgg aaaccacact     9060

gtttaaacag tgttccttaa tcaaggatac ctcttttttt ttccttggtt ccactaattc     9120

atcggttttt tttttggaag acatcttttc caacgaaaag aatatacata tcgtttaaga     9180

gaaattctcc aaatttgtaa agaagcggac ccagacttaa                           9220


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N886 Primer

<400>  59
caatgattgt tggtaaaggg                                                   20


<210>  60
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1214 Primer

<400>  60
aaaaaggggg tagaagcgtt ttgaagctat                                        30


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP512 Primer

<400>  61
aaagttggca tagcggaaac tt                                                22


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N160SeqR5 Primer

<400>  62
tgagcccgaa agagaggat                                                    19


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP540 Primer

<400>  63
taggcataat caccgaagaa g                                                 21


<210>  64
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP835 Primer

<400>  64
cacaaacgtt gaatcatgag ttttatgtta attagctttg ttcttcttgt tattgtattg       60


<210>  65
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP836 Primer

<400>  65
caaagagaac aacacaatac aataacaaga agaacaaagc taattaacat aaaactcatg       60


<210>  66
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP837 Primer

<400>  66
ttgaaaagct ttatggaccc tgaaaccaca gccacattaa gtaaataaat taatcagcat       60


<210>  67
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP838 Primer

<400>  67
tttattattt aattttatgc tgattaattt atttacttaa tgtggctgtg gtttcagggt       60


<210>  68
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP839 Primer

<400>  68
gatgatggtc gagggggagt agaactgggc ggtcaacaaa ggccatgaag ctttttcttt       60


<210>  69
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP840 Primer

<400>  69
aaaaaaaaaa aattggaaag aaaaagcttc atggcctttg ttgaccgccc agttctactc       60


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP841 Primer

<400>  70
tcaggcagcg cctgcgttcg ag                                                22


<210>  71
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ura3-end Primer

<400>  71
gcatatttga gaagatgcgg ccagcaaaac                                        30


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP541 Primer

<400>  72
aaaatggtaa gcagctgaaa g                                                 21


<210>  73
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP530 Primer

<400>  73
aattggcgcg ccatgaaagc tctggtttat cac                                    33


<210>  74
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oBP531 Primer

<400>  74
tgaatcatga gttttatgtt aattagctca ggcagcgcct gcgttcgag                   49


<210>  75
<211>  15539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLH468 Plasmid

<400>  75
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accataaatt cccgttttaa gagcttggtg agcgctagga gtcactgcca ggtatcgttt      240

gaacacggca ttagtcaggg aagtcataac acagtccttt cccgcaattt tctttttcta      300

ttactcttgg cctcctctag tacactctat atttttttat gcctcggtaa tgattttcat      360

tttttttttt ccacctagcg gatgactctt tttttttctt agcgattggc attatcacat      420

aatgaattat acattatata aagtaatgtg atttcttcga agaatatact aaaaaatgag      480

caggcaagat aaacgaaggc aaagatgaca gagcagaaag ccctagtaaa gcgtattaca      540

aatgaaacca agattcagat tgcgatctct ttaaagggtg gtcccctagc gatagagcac      600

tcgatcttcc cagaaaaaga ggcagaagca gtagcagaac aggccacaca atcgcaagtg      660

attaacgtcc acacaggtat agggtttctg gaccatatga tacatgctct ggccaagcat      720

tccggctggt cgctaatcgt tgagtgcatt ggtgacttac acatagacga ccatcacacc      780

actgaagact gcgggattgc tctcggtcaa gcttttaaag aggccctagg ggccgtgcgt      840

ggagtaaaaa ggtttggatc aggatttgcg cctttggatg aggcactttc cagagcggtg      900

gtagatcttt cgaacaggcc gtacgcagtt gtcgaacttg gtttgcaaag ggagaaagta      960

ggagatctct cttgcgagat gatcccgcat tttcttgaaa gctttgcaga ggctagcaga     1020

attaccctcc acgttgattg tctgcgaggc aagaatgatc atcaccgtag tgagagtgcg     1080

ttcaaggctc ttgcggttgc cataagagaa gccacctcgc ccaatggtac caacgatgtt     1140

ccctccacca aaggtgttct tatgtagtga caccgattat ttaaagctgc agcatacgat     1200

atatatacat gtgtatatat gtatacctat gaatgtcagt aagtatgtat acgaacagta     1260

tgatactgaa gatgacaagg taatgcatca ttctatacgt gtcattctga acgaggcgcg     1320

ctttcctttt ttctttttgc tttttctttt tttttctctt gaactcgacg gatctatgcg     1380

gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggaaat tgtaagcgtt     1440

aatattttgt taaaattcgc gttaaatttt tgttaaatca gctcattttt taaccaatag     1500

gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt     1560

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga     1620

aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg     1680

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct     1740

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc     1800

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt     1860

aatgcgccgc tacagggcgc gtccattcgc cattcaggct gcgcaactgt tgggaagggc     1920

gcggtgcggg cctcttcgct attacgccag ctggcgaaag ggggatgtgc tgcaaggcga     1980

ttaagttggg taacgccagg gttttcccag tcacgacgtt gtaaaacgac ggccagtgag     2040

cgcgcgtaat acgactcact atagggcgaa ttgggtaccg ggccccccct cgaggtcgac     2100

ggcgcgccac tggtagagag cgactttgta tgccccaatt gcgaaacccg cgatatcctt     2160

ctcgattctt tagtacccga ccaggacaag gaaaaggagg tcgaaacgtt tttgaagaaa     2220

caagaggaac tacacggaag ctctaaagat ggcaaccagc cagaaactaa gaaaatgaag     2280

ttgatggatc caactggcac cgctggcttg aacaacaata ccagccttcc aacttctgta     2340

aataacggcg gtacgccagt gccaccagta ccgttacctt tcggtatacc tcctttcccc     2400

atgtttccaa tgcccttcat gcctccaacg gctactatca caaatcctca tcaagctgac     2460

gcaagcccta agaaatgaat aacaatactg acagtactaa ataattgcct acttggcttc     2520

acatacgttg catacgtcga tatagataat aatgataatg acagcaggat tatcgtaata     2580

cgtaatagct gaaaatctca aaaatgtgtg ggtcattacg taaataatga taggaatggg     2640

attcttctat ttttcctttt tccattctag cagccgtcgg gaaaacgtgg catcctctct     2700

ttcgggctca attggagtca cgctgccgtg agcatcctct ctttccatat ctaacaactg     2760

agcacgtaac caatggaaaa gcatgagctt agcgttgctc caaaaaagta ttggatggtt     2820

aataccattt gtctgttctc ttctgacttt gactcctcaa aaaaaaaaat ctacaatcaa     2880

cagatcgctt caattacgcc ctcacaaaaa cttttttcct tcttcttcgc ccacgttaaa     2940

ttttatccct catgttgtct aacggatttc tgcacttgat ttattataaa aagacaaaga     3000

cataatactt ctctatcaat ttcagttatt gttcttcctt gcgttattct tctgttcttc     3060

tttttctttt gtcatatata accataacca agtaatacat attcaaacta gtatgactga     3120

caaaaaaact cttaaagact taagaaatcg tagttctgtt tacgattcaa tggttaaatc     3180

acctaatcgt gctatgttgc gtgcaactgg tatgcaagat gaagactttg aaaaacctat     3240

cgtcggtgtc atttcaactt gggctgaaaa cacaccttgt aatatccact tacatgactt     3300

tggtaaacta gccaaagtcg gtgttaagga agctggtgct tggccagttc agttcggaac     3360

aatcacggtt tctgatggaa tcgccatggg aacccaagga atgcgtttct ccttgacatc     3420

tcgtgatatt attgcagatt ctattgaagc agccatggga ggtcataatg cggatgcttt     3480

tgtagccatt ggcggttgtg ataaaaacat gcccggttct gttatcgcta tggctaacat     3540

ggatatccca gccatttttg cttacggcgg aacaattgca cctggtaatt tagacggcaa     3600

agatatcgat ttagtctctg tctttgaagg tgtcggccat tggaaccacg gcgatatgac     3660

caaagaagaa gttaaagctt tggaatgtaa tgcttgtccc ggtcctggag gctgcggtgg     3720

tatgtatact gctaacacaa tggcgacagc tattgaagtt ttgggactta gccttccggg     3780

ttcatcttct cacccggctg aatccgcaga aaagaaagca gatattgaag aagctggtcg     3840

cgctgttgtc aaaatgctcg aaatgggctt aaaaccttct gacattttaa cgcgtgaagc     3900

ttttgaagat gctattactg taactatggc tctgggaggt tcaaccaact caacccttca     3960

cctcttagct attgcccatg ctgctaatgt ggaattgaca cttgatgatt tcaatacttt     4020

ccaagaaaaa gttcctcatt tggctgattt gaaaccttct ggtcaatatg tattccaaga     4080

cctttacaag gtcggagggg taccagcagt tatgaaatat ctccttaaaa atggcttcct     4140

tcatggtgac cgtatcactt gtactggcaa aacagtcgct gaaaatttga aggcttttga     4200

tgatttaaca cctggtcaaa aggttattat gccgcttgaa aatcctaaac gtgaagatgg     4260

tccgctcatt attctccatg gtaacttggc tccagacggt gccgttgcca aagtttctgg     4320

tgtaaaagtg cgtcgtcatg tcggtcctgc taaggtcttt aattctgaag aagaagccat     4380

tgaagctgtc ttgaatgatg atattgttga tggtgatgtt gttgtcgtac gttttgtagg     4440

accaaagggc ggtcctggta tgcctgaaat gctttccctt tcatcaatga ttgttggtaa     4500

agggcaaggt gaaaaagttg cccttctgac agatggccgc ttctcaggtg gtacttatgg     4560

tcttgtcgtg ggtcatatcg ctcctgaagc acaagatggc ggtccaatcg cctacctgca     4620

aacaggagac atagtcacta ttgaccaaga cactaaggaa ttacactttg atatctccga     4680

tgaagagtta aaacatcgtc aagagaccat tgaattgcca ccgctctatt cacgcggtat     4740

ccttggtaaa tatgctcaca tcgtttcgtc tgcttctagg ggagccgtaa cagacttttg     4800

gaagcctgaa gaaactggca aaaaatgttg tcctggttgc tgtggttaag cggccgcgtt     4860

aattcaaatt aattgatata gttttttaat gagtattgaa tctgtttaga aataatggaa     4920

tattattttt atttatttat ttatattatt ggtcggctct tttcttctga aggtcaatga     4980

caaaatgata tgaaggaaat aatgatttct aaaattttac aacgtaagat atttttacaa     5040

aagcctagct catcttttgt catgcactat tttactcacg cttgaaatta acggccagtc     5100

cactgcggag tcatttcaaa gtcatcctaa tcgatctatc gtttttgata gctcattttg     5160

gagttcgcga ttgtcttctg ttattcacaa ctgttttaat ttttatttca ttctggaact     5220

cttcgagttc tttgtaaagt ctttcatagt agcttacttt atcctccaac atatttaact     5280

tcatgtcaat ttcggctctt aaattttcca catcatcaag ttcaacatca tcttttaact     5340

tgaatttatt ctctagctct tccaaccaag cctcattgct ccttgattta ctggtgaaaa     5400

gtgatacact ttgcgcgcaa tccaggtcaa aactttcctg caaagaattc accaatttct     5460

cgacatcata gtacaatttg ttttgttctc ccatcacaat ttaatatacc tgatggattc     5520

ttatgaagcg ctgggtaatg gacgtgtcac tctacttcgc ctttttccct actcctttta     5580

gtacggaaga caatgctaat aaataagagg gtaataataa tattattaat cggcaaaaaa     5640

gattaaacgc caagcgttta attatcagaa agcaaacgtc gtaccaatcc ttgaatgctt     5700

cccaattgta tattaagagt catcacagca acatattctt gttattaaat taattattat     5760

tgatttttga tattgtataa aaaaaccaaa tatgtataaa aaaagtgaat aaaaaatacc     5820

aagtatggag aaatatatta gaagtctata cgttaaacca cccgggcccc ccctcgaggt     5880

cgacggtatc gataagcttg atatcgaatt cctgcagccc gggggatcca ctagttctag     5940

agcggccgct ctagaactag taccacaggt gttgtcctct gaggacataa aatacacacc     6000

gagattcatc aactcattgc tggagttagc atatctacaa ttgggtgaaa tggggagcga     6060

tttgcaggca tttgctcggc atgccggtag aggtgtggtc aataagagcg acctcatgct     6120

atacctgaga aagcaacctg acctacagga aagagttact caagaataag aattttcgtt     6180

ttaaaaccta agagtcactt taaaatttgt atacacttat tttttttata acttatttaa     6240

taataaaaat cataaatcat aagaaattcg cttactctta attaatcaaa aagttaaaat     6300

tgtacgaata gattcaccac ttcttaacaa atcaaaccct tcattgattt tctcgaatgg     6360

caatacatgt gtaattaaag gatcaagagc aaacttcttc gccataaagt cggcaacaag     6420

ttttggaaca ctatccttgc tcttaaaacc gccaaatata gctcccttcc atgtacgacc     6480

gcttagcaac agcataggat tcatcgacaa attttgtgaa tcaggaggaa cacctacgat     6540

cacactgact ccatatgcct cttgacagca ggacaacgca gttaccatag tatcaagacg     6600

gcctataact tcaaaagaga aatcaactcc accgtttgac atttcagtaa ggacttcttg     6660

tattggtttc ttataatctt gagggttaac acattcagta gccccgacct ccttagcttt     6720

tgcaaatttg tccttattga tgtctacacc tataatcctc gctgcgcctg cagctttaca     6780

ccccataata acgcttagtc ctactcctcc taaaccgaat actgcacaag tcgaaccctg     6840

tgtaaccttt gcaactttaa ctgcggaacc gtaaccggtg gaaaatccgc accctatcaa     6900

gcaaactttt tccagtggtg aagctgcatc gattttagcg acagatatct cgtccaccac     6960

tgtgtattgg gaaaatgtag aagtaccaag gaaatggtgt ataggtttcc ctctgcatgt     7020

aaatctgctt gtaccatcct gcatagtacc tctaggcata gacaaatcat ttttaaggca     7080

gaaattaccc tcaggatgtt tgcagactct acacttacca cattgaggag tgaacagtgg     7140

gatcacttta tcaccaggac gaacagtggt aacaccttca cctatggatt caacgattcc     7200

ggcagcctcg tgtcccgcga ttactggcaa aggagtaact agagtgccac tcaccacatg     7260

gtcgtcggat ctacagattc cggtggcaac catcttgatt ctaacctcgt gtgcttttgg     7320

tggcgctact tctacttctt ctatgctaaa cggctttttc tcttcccaca aaactgccgc     7380

tttacactta ataactttac cggctgttga catcctcagc tagctattgt aatatgtgtg     7440

tttgtttgga ttattaagaa gaataattac aaaaaaaatt acaaaggaag gtaattacaa     7500

cagaattaag aaaggacaag aaggaggaag agaatcagtt cattatttct tctttgttat     7560

ataacaaacc caagtagcga tttggccata cattaaaagt tgagaaccac cctccctggc     7620

aacagccaca actcgttacc attgttcatc acgatcatga aactcgctgt cagctgaaat     7680

ttcacctcag tggatctctc tttttattct tcatcgttcc actaaccttt ttccatcagc     7740

tggcagggaa cggaaagtgg aatcccattt agcgagcttc ctcttttctt caagaaaaga     7800

cgaagcttgt gtgtgggtgc gcgcgctagt atctttccac attaagaaat ataccataaa     7860

ggttacttag acatcactat ggctatatat atatatatat atatatgtaa cttagcacca     7920

tcgcgcgtgc atcactgcat gtgttaaccg aaaagtttgg cgaacacttc accgacacgg     7980

tcatttagat ctgtcgtctg cattgcacgt cccttagcct taaatcctag gcgggagcat     8040

tctcgtgtaa ttgtgcagcc tgcgtagcaa ctcaacatag cgtagtctac ccagtttttc     8100

aagggtttat cgttagaaga ttctcccttt tcttcctgct cacaaatctt aaagtcatac     8160

attgcacgac taaatgcaag catgcggatc ccccgggctg caggaattcg atatcaagct     8220

tatcgatacc gtcgactggc cattaatctt tcccatatta gatttcgcca agccatgaaa     8280

gttcaagaaa ggtctttaga cgaattaccc ttcatttctc aaactggcgt caagggatcc     8340

tggtatggtt ttatcgtttt atttctggtt cttatagcat cgttttggac ttctctgttc     8400

ccattaggcg gttcaggagc cagcgcagaa tcattctttg aaggatactt atcctttcca     8460

attttgattg tctgttacgt tggacataaa ctgtatacta gaaattggac tttgatggtg     8520

aaactagaag atatggatct tgataccggc agaaaacaag tagatttgac tcttcgtagg     8580

gaagaaatga ggattgagcg agaaacatta gcaaaaagat ccttcgtaac aagattttta     8640

catttctggt gttgaaggga aagatatgag ctatacagcg gaatttccat atcactcaga     8700

ttttgttatc taattttttc cttcccacgt ccgcgggaat ctgtgtatat tactgcatct     8760

agatatatgt tatcttatct tggcgcgtac atttaatttt caacgtattc tataagaaat     8820

tgcgggagtt tttttcatgt agatgatact gactgcacgc aaatataggc atgatttata     8880

ggcatgattt gatggctgta ccgataggaa cgctaagagt aacttcagaa tcgttatcct     8940

ggcggaaaaa attcatttgt aaactttaaa aaaaaaagcc aatatcccca aaattattaa     9000

gagcgcctcc attattaact aaaatttcac tcagcatcca caatgtatca ggtatctact     9060

acagatatta catgtggcga aaaagacaag aacaatgcaa tagcgcatca agaaaaaaca     9120

caaagctttc aatcaatgaa tcgaaaatgt cattaaaata gtatataaat tgaaactaag     9180

tcataaagct ataaaaagaa aatttattta aatgcaagat ttaaagtaaa ttcacggccc     9240

tgcaggcctc agctcttgtt ttgttctgca aataacttac ccatcttttt caaaacttta     9300

ggtgcaccct cctttgctag aataagttct atccaataca tcctatttgg atctgcttga     9360

gcttctttca tcacggatac gaattcattt tctgttctca caattttgga cacaactctg     9420

tcttccgttg ccccgaaact ttctggcagt tttgagtaat tccacatagg aatgtcatta     9480

taactctggt tcggaccatg aatttccctc tcaaccgtgt aaccatcgtt attaatgata     9540

aagcagattg ggtttatctt ctctctaatg gctagtccta attcttggac agtcagttgc     9600

aatgatccat ctccgataaa caataaatgt ctagattctt tatctgcaat ttggctgcct     9660

agagctgcgg ggaaagtgta tcctatagat ccccacaagg gttgaccaat aaaatgtgat     9720

ttcgatttca gaaatataga tgaggcaccg aagaaagaag tgccttgttc agccacgatc     9780

gtctcattac tttgggtcaa attttcgaca gcttgccaca gtctatcttg tgacaacagc     9840

gcgttagaag gtacaaaatc ttcttgcttt ttatctatgt acttgccttt atattcaatt     9900

tcggacaagt caagaagaga tgatatcagg gattcgaagt cgaaattttg gattctttcg     9960

ttgaaaattt taccttcatc gatattcaag gaaatcattt tattttcatt aagatggtga    10020

gtaaatgcac ccgtactaga atcggtaagc tttacaccca acataagaat aaaatcagca    10080

gattccacaa attccttcaa gtttggctct gacagagtac cgttgtaaat ccccaaaaat    10140

gagggcaatg cttcatcaac agatgattta ccaaagttca aagtagtaat aggtaactta    10200

gtctttgaaa taaactgagt aacagtcttc tctaggccga acgatataat ttcatggcct    10260

gtgattacaa ttggtttctt ggcattcttc agactttcct gtattttgtt cagaatctct    10320

tgatcagatg tattcgacgt ggaattttcc ttcttaagag gcaaggatgg tttttcagcc    10380

ttagcggcag ctacatctac aggtaaattg atgtaaaccg gctttctttc ctttagtaag    10440

gcagacaaca ctctatcaat ttcaacagtt gcattctcgg ctgtcaataa agtcctggca    10500

gcagtaaccg gttcgtgcat cttcataaag tgcttgaaat caccatcagc caacgtatgg    10560

tgaacaaact taccttcgtt ctgcactttc gaggtaggag atcccacgat ctcaacaaca    10620

ggcaggttct cagcatagga gcccgctaag ccattaactg cggataattc gccaacacca    10680

aatgtagtca agaatgccgc agcctttttc gttcttgcgt acccgtcggc catataggag    10740

gcatttaact cattagcatt tcccacccat ttcatatctt tgtgtgaaat aatttgatct    10800

agaaattgca aattgtagtc acctggtact ccgaatattt cttctatacc taattcgtgt    10860

aatctgtcca acagatagtc acctactgta tacattttgt ttactagttt atgtgtgttt    10920

attcgaaact aagttcttgg tgttttaaaa ctaaaaaaaa gactaactat aaaagtagaa    10980

tttaagaagt ttaagaaata gatttacaga attacaatca atacctaccg tctttatata    11040

cttattagtc aagtagggga ataatttcag ggaactggtt tcaacctttt ttttcagctt    11100

tttccaaatc agagagagca gaaggtaata gaaggtgtaa gaaaatgaga tagatacatg    11160

cgtgggtcaa ttgccttgtg tcatcattta ctccaggcag gttgcatcac tccattgagg    11220

ttgtgcccgt tttttgcctg tttgtgcccc tgttctctgt agttgcgcta agagaatgga    11280

cctatgaact gatggttggt gaagaaaaca atattttggt gctgggattc tttttttttc    11340

tggatgccag cttaaaaagc gggctccatt atatttagtg gatgccagga ataaactgtt    11400

cacccagaca cctacgatgt tatatattct gtgtaacccg ccccctattt tgggcatgta    11460

cgggttacag cagaattaaa aggctaattt tttgactaaa taaagttagg aaaatcacta    11520

ctattaatta tttacgtatt ctttgaaatg gcagtattga taatgataaa ctcgaactga    11580

aaaagcgtgt tttttattca aaatgattct aactccctta cgtaatcaag gaatcttttt    11640

gccttggcct ccgcgtcatt aaacttcttg ttgttgacgc taacattcaa cgctagtata    11700

tattcgtttt tttcaggtaa gttcttttca acgggtctta ctgatgaggc agtcgcgtct    11760

gaacctgtta agaggtcaaa tatgtcttct tgaccgtacg tgtcttgcat gttattagct    11820

ttgggaattt gcatcaagtc ataggaaaat ttaaatcttg gctctcttgg gctcaaggtg    11880

acaaggtcct cgaaaatagg gcgcgcccca ccgcggtgga gctccagctt ttgttccctt    11940

tagtgagggt taattgcgcg cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat    12000

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg    12060

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag    12120

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt    12180

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg    12240

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg    12300

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag    12360

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga    12420

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct    12480

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc    12540

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg    12600

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc    12660

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca    12720

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag    12780

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct    12840

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc    12900

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga    12960

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca    13020

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat    13080

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac    13140

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt    13200

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt    13260

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag    13320

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct    13380

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt    13440

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc    13500

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt    13560

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg    13620

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg    13680

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct    13740

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc    13800

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt    13860

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt    13920

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg    13980

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat    14040

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg    14100

cgcacatttc cccgaaaagt gccacctgaa cgaagcatct gtgcttcatt ttgtagaaca    14160

aaaatgcaac gcgagagcgc taatttttca aacaaagaat ctgagctgca tttttacaga    14220

acagaaatgc aacgcgaaag cgctatttta ccaacgaaga atctgtgctt catttttgta    14280

aaacaaaaat gcaacgcgag agcgctaatt tttcaaacaa agaatctgag ctgcattttt    14340

acagaacaga aatgcaacgc gagagcgcta ttttaccaac aaagaatcta tacttctttt    14400

ttgttctaca aaaatgcatc ccgagagcgc tatttttcta acaaagcatc ttagattact    14460

ttttttctcc tttgtgcgct ctataatgca gtctcttgat aactttttgc actgtaggtc    14520

cgttaaggtt agaagaaggc tactttggtg tctattttct cttccataaa aaaagcctga    14580

ctccacttcc cgcgtttact gattactagc gaagctgcgg gtgcattttt tcaagataaa    14640

ggcatccccg attatattct ataccgatgt ggattgcgca tactttgtga acagaaagtg    14700

atagcgttga tgattcttca ttggtcagaa aattatgaac ggtttcttct attttgtctc    14760

tatatactac gtataggaaa tgtttacatt ttcgtattgt tttcgattca ctctatgaat    14820

agttcttact acaatttttt tgtctaaaga gtaatactag agataaacat aaaaaatgta    14880

gaggtcgagt ttagatgcaa gttcaaggag cgaaaggtgg atgggtaggt tatataggga    14940

tatagcacag agatatatag caaagagata cttttgagca atgtttgtgg aagcggtatt    15000

cgcaatattt tagtagctcg ttacagtccg gtgcgttttt ggttttttga aagtgcgtct    15060

tcagagcgct tttggttttc aaaagcgctc tgaagttcct atactttcta gagaatagga    15120

acttcggaat aggaacttca aagcgtttcc gaaaacgagc gcttccgaaa atgcaacgcg    15180

agctgcgcac atacagctca ctgttcacgt cgcacctata tctgcgtgtt gcctgtatat    15240

atatatacat gagaagaacg gcatagtgcg tgtttatgct taaatgcgta cttatatgcg    15300

tctatttatg taggatgaaa ggtagtctag tacctcctgt gatattatcc cattccatgc    15360

ggggtatcgt atgcttcctt cagcactacc ctttagctgt tctatatgct gccactcctc    15420

aattggatta gtctcatcct tcaatgctat catttccttt gatattggat catactaaga    15480

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtc     15539


<210>  76
<211>  1123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiADH coding region (codon optimized for yeast) plus 5'homology 
       to GPM promoter and 3'homology to ADH1 terminator

<400>  76
gaattccaaa caaacacaca tattacaata gctagctgag gatgaaagca ttagtgtata       60

ggggcccagg ccagaagttg gtggaagaga gacagaagcc agagcttaag gaacctggtg      120

acgctatagt gaaggtaaca aagactacaa tttgcggaac cgatctacac attcttaaag      180

gtgacgttgc gacttgtaaa cccggtcgtg tattagggca tgaaggagtg ggggttattg      240

aatcagtcgg atctggggtt actgctttcc aaccaggcga tagagttttg atatcatgta      300

tatcgagttg cggaaagtgc tcattttgta gaagaggaat gttcagtcac tgtacgaccg      360

ggggttggat tctgggcaac gaaattgatg gtacccaagc agagtacgta agagtaccac      420

atgctgacac atccctttat cgtattccgg caggtgcgga tgaagaggcc ttagtcatgt      480

tatcagatat tctaccaacg ggttttgagt gcggagtcct aaacggcaaa gtcgcacctg      540

gttcttcggt ggctatagta ggtgctggtc ccgttggttt ggccgcctta ctgacagcac      600

aattctactc cccagctgaa atcataatga tcgatcttga tgataacagg ctgggattag      660

ccaaacaatt tggtgccacc agaacagtaa actccacggg tggtaacgcc gcagccgaag      720

tgaaagctct tactgaaggc ttaggtgttg atactgcgat tgaagcagtt gggatacctg      780

ctacatttga attgtgtcag aatatcgtag ctcccggtgg aactatcgct aatgtcggcg      840

ttcacggtag caaagttgat ttgcatcttg aaagtttatg gtcccataat gtcacgatta      900

ctacaaggtt ggttgacacg gctaccaccc cgatgttact gaaaactgtt caaagtcaca      960

agctagatcc atctagattg ataacacata gattcagcct ggaccagatc ttggacgcat     1020

atgaaacttt tggccaagct gcgtctactc aagcactaaa agtcatcatt tcgatggagg     1080

cttgattaat taagagtaag cgaatttctt atgatttgga tcc                       1123


<210>  77
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1092 Primer

<400>  77
agagttttga tatcatgtat atcgag                                            26


<210>  78
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1093 Primer

<400>  78
tttcaagatg caaatcaact ttgcta                                            26


<210>  79
<211>  398
<212>  PRT
<213>  Pseudomonas Putida

<400>  79

Ser Gly Asn Arg Gly Val Val Tyr Leu Gly Ser Gly Lys Val Glu Val 
1               5                   10                  15      


Gln Lys Ile Asp Tyr Pro Lys Met Gln Asp Pro Arg Gly Lys Lys Ile 
            20                  25                  30          


Glu His Gly Val Ile Leu Lys Val Val Ser Thr Asn Ile Cys Gly Ser 
        35                  40                  45              


Asp Gln His Met Val Arg Gly Arg Thr Thr Ala Gln Val Gly Leu Val 
    50                  55                  60                  


Leu Gly His Glu Ile Thr Gly Glu Val Ile Glu Lys Gly Arg Asp Val 
65                  70                  75                  80  


Glu Asn Leu Gln Ile Gly Asp Leu Val Ser Val Pro Phe Asn Val Ala 
                85                  90                  95      


Cys Gly Arg Cys Arg Ser Cys Lys Glu Met His Thr Gly Val Cys Leu 
            100                 105                 110         


Thr Val Asn Pro Ala Arg Ala Gly Gly Ala Tyr Gly Tyr Val Asp Met 
        115                 120                 125             


Gly Asp Trp Thr Gly Gly Gln Ala Glu Tyr Val Leu Val Pro Tyr Ala 
    130                 135                 140                 


Asp Phe Asn Leu Leu Lys Leu Pro Asp Arg Asp Lys Ala Met Glu Lys 
145                 150                 155                 160 


Ile Arg Asp Leu Thr Cys Leu Ser Asp Ile Leu Pro Thr Gly Tyr His 
                165                 170                 175     


Gly Ala Val Thr Ala Gly Val Gly Pro Gly Ser Thr Val Tyr Val Ala 
            180                 185                 190         


Gly Ala Gly Pro Val Gly Leu Ala Ala Ala Ala Ser Ala Arg Leu Leu 
        195                 200                 205             


Gly Ala Ala Val Val Ile Val Gly Asp Leu Asn Pro Ala Arg Leu Ala 
    210                 215                 220                 


His Ala Lys Ala Gln Gly Phe Glu Ile Ala Asp Leu Ser Leu Asp Thr 
225                 230                 235                 240 


Pro Leu His Glu Gln Ile Ala Ala Leu Leu Gly Glu Pro Glu Val Asp 
                245                 250                 255     


Cys Ala Val Asp Ala Val Gly Phe Glu Ala Arg Gly His Gly His Glu 
            260                 265                 270         


Gly Ala Lys His Glu Ala Pro Ala Thr Val Leu Asn Ser Leu Met Gln 
        275                 280                 285             


Val Thr Arg Val Ala Gly Lys Ile Gly Ile Pro Gly Leu Tyr Val Thr 
    290                 295                 300                 


Glu Asp Pro Gly Ala Val Asp Ala Ala Ala Lys Ile Gly Ser Leu Ser 
305                 310                 315                 320 


Ile Arg Phe Gly Leu Gly Trp Ala Lys Ser His Ser Phe His Thr Gly 
                325                 330                 335     


Gln Thr Pro Val Met Lys Tyr Asn Arg Ala Leu Met Gln Ala Ile Met 
            340                 345                 350         


Trp Asp Arg Ile Asn Ile Ala Glu Val Val Gly Val Gln Val Ile Ser 
        355                 360                 365             


Leu Asp Asp Ala Pro Arg Gly Tyr Gly Glu Phe Asp Ala Gly Val Pro 
    370                 375                 380                 


Lys Lys Phe Val Ile Asp Pro His Lys Thr Phe Ser Ala Ala 
385                 390                 395             


<210>  80
<211>  348
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  80

Met Ser Glu Lys Met Val Ala Ile Met Lys Thr Lys Pro Gly Tyr Gly 
1               5                   10                  15      


Ala Glu Leu Val Glu Val Asp Val Pro Lys Pro Gly Pro Gly Glu Val 
            20                  25                  30          


Leu Ile Lys Val Leu Ala Thr Ser Ile Cys Gly Thr Asp Leu His Ile 
        35                  40                  45              


Tyr Glu Trp Asn Glu Trp Ala Gln Ser Arg Ile Lys Pro Pro Gln Ile 
    50                  55                  60                  


Met Gly His Glu Val Ala Gly Glu Val Val Glu Ile Gly Pro Gly Val 
65                  70                  75                  80  


Glu Gly Ile Glu Val Gly Asp Tyr Val Ser Val Glu Thr His Ile Val 
                85                  90                  95      


Cys Gly Lys Cys Tyr Ala Cys Arg Arg Gly Gln Tyr His Val Cys Gln 
            100                 105                 110         


Asn Thr Lys Ile Phe Gly Val Asp Thr Asp Gly Val Phe Ala Glu Tyr 
        115                 120                 125             


Ala Val Val Pro Ala Gln Asn Ile Trp Lys Asn Pro Lys Ser Ile Pro 
    130                 135                 140                 


Pro Glu Tyr Ala Thr Leu Gln Glu Pro Leu Gly Asn Ala Val Asp Thr 
145                 150                 155                 160 


Val Leu Ala Gly Pro Ile Ser Gly Lys Ser Val Leu Ile Thr Gly Ala 
                165                 170                 175     


Gly Pro Leu Gly Leu Leu Gly Ile Ala Val Ala Lys Ala Ser Gly Ala 
            180                 185                 190         


Tyr Pro Val Ile Val Ser Glu Pro Ser Asp Phe Arg Arg Glu Leu Ala 
        195                 200                 205             


Lys Lys Val Gly Ala Asp Tyr Val Ile Asn Pro Phe Glu Glu Asp Val 
    210                 215                 220                 


Val Lys Glu Val Met Asp Ile Thr Asp Gly Asn Gly Val Asp Val Phe 
225                 230                 235                 240 


Leu Glu Phe Ser Gly Ala Pro Lys Ala Leu Glu Gln Gly Leu Gln Ala 
                245                 250                 255     


Val Thr Pro Ala Gly Arg Val Ser Leu Leu Gly Leu Tyr Pro Gly Lys 
            260                 265                 270         


Val Thr Ile Asp Phe Asn Asn Leu Ile Ile Phe Lys Ala Leu Thr Ile 
        275                 280                 285             


Tyr Gly Ile Thr Gly Arg His Leu Trp Glu Thr Trp Tyr Thr Val Ser 
    290                 295                 300                 


Arg Leu Leu Gln Ser Gly Lys Leu Asn Leu Asp Pro Ile Ile Thr His 
305                 310                 315                 320 


Lys Tyr Lys Gly Phe Asp Lys Tyr Glu Glu Ala Phe Glu Leu Met Arg 
                325                 330                 335     


Ala Gly Lys Thr Gly Lys Val Val Phe Met Leu Lys 
            340                 345             


<210>  81
<211>  11017
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRS426::GPD-xpk1+ADH-eutD plasmid

<400>  81
gatcccccgg gctgcaggaa ttcgatatca agcttatcga taccgtcgac ctcgaggggg       60

ggcccggtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt      120

ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat      180

ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag      240

ttgcgcagcc tgaatggcga atggcgcgac gcgccctgta gcggcgcatt aagcgcggcg      300

ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct      360

ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat      420

cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt      480

gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg      540

acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac      600

cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta      660

aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca      720

atttcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatagggt      780

aataactgat ataattaaat tgaagctcta atttgtgagt ttagtataca tgcatttact      840

tataatacag ttttttagtt ttgctggccg catcttctca aatatgcttc ccagcctgct      900

tttctgtaac gttcaccctc taccttagca tcccttccct ttgcaaatag tcctcttcca      960

acaataataa tgtcagatcc tgtagagacc acatcatcca cggttctata ctgttgaccc     1020

aatgcgtctc ccttgtcatc taaacccaca ccgggtgtca taatcaacca atcgtaacct     1080

tcatctcttc cacccatgtc tctttgagca ataaagccga taacaaaatc tttgtcgctc     1140

ttcgcaatgt caacagtacc cttagtatat tctccagtag atagggagcc cttgcatgac     1200

aattctgcta acatcaaaag gcctctaggt tcctttgtta cttcttctgc cgcctgcttc     1260

aaaccgctaa caatacctgg gcccaccaca ccgtgtgcat tcgtaatgtc tgcccattct     1320

gctattctgt atacacccgc agagtactgc aatttgactg tattaccaat gtcagcaaat     1380

tttctgtctt cgaagagtaa aaaattgtac ttggcggata atgcctttag cggcttaact     1440

gtgccctcca tggaaaaatc agtcaagata tccacatgtg tttttagtaa acaaattttg     1500

ggacctaatg cttcaactaa ctccagtaat tccttggtgg tacgaacatc caatgaagca     1560

cacaagtttg tttgcttttc gtgcatgata ttaaatagct tggcagcaac aggactagga     1620

tgagtagcag cacgttcctt atatgtagct ttcgacatga tttatcttcg tttcctgcag     1680

gtttttgttc tgtgcagttg ggttaagaat actgggcaat ttcatgtttc ttcaacacta     1740

catatgcgta tatataccaa tctaagtctg tgctccttcc ttcgttcttc cttctgttcg     1800

gagattaccg aatcaaaaaa atttcaaaga aaccgaaatc aaaaaaaaga ataaaaaaaa     1860

aatgatgaat tgaattgaaa agctgtggta tggtgcactc tcagtacaat ctgctctgat     1920

gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct     1980

tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt     2040

cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta     2100

tttttatagg ttaatgtcat gataataatg gtttcttagt atgatccaat atcaaaggaa     2160

atgatagcat tgaaggatga gactaatcca attgaggagt ggcagcatat agaacagcta     2220

aagggtagtg ctgaaggaag catacgatac cccgcatgga atgggataat atcacaggag     2280

gtactagact acctttcatc ctacataaat agacgcatat aagtacgcat ttaagcataa     2340

acacgcacta tgccgttctt ctcatgtata tatatataca ggcaacacgc agatataggt     2400

gcgacgtgaa cagtgagctg tatgtgcgca gctcgcgttg cattttcgga agcgctcgtt     2460

ttcggaaacg ctttgaagtt cctattccga agttcctatt ctctagaaag tataggaact     2520

tcagagcgct tttgaaaacc aaaagcgctc tgaagacgca ctttcaaaaa accaaaaacg     2580

caccggactg taacgagcta ctaaaatatt gcgaataccg cttccacaaa cattgctcaa     2640

aagtatctct ttgctatata tctctgtgct atatccctat ataacctacc catccacctt     2700

tcgctccttg aacttgcatc taaactcgac ctctacattt tttatgttta tctctagtat     2760

tactctttag acaaaaaaat tgtagtaaga actattcata gagtgaatcg aaaacaatac     2820

gaaaatgtaa acatttccta tacgtagtat atagagacaa aatagaagaa accgttcata     2880

attttctgac caatgaagaa tcatcaacgc tatcactttc tgttcacaaa gtatgcgcaa     2940

tccacatcgg tatagaatat aatcggggat gcctttatct tgaaaaaatg cacccgcagc     3000

ttcgctagta atcagtaaac gcgggaagtg gagtcaggct ttttttatgg aagagaaaat     3060

agacaccaaa gtagccttct tctaacctta acggacctac agtgcaaaaa gttatcaaga     3120

gactgcatta tagagcgcac aaaggagaaa aaaagtaatc taagatgctt tgttagaaaa     3180

atagcgctct cgggatgcat ttttgtagaa caaaaaagaa gtatagattc tttgttggta     3240

aaatagcgct ctcgcgttgc atttctgttc tgtaaaaatg cagctcagat tctttgtttg     3300

aaaaattagc gctctcgcgt tgcatttttg ttttacaaaa atgaagcaca gattcttcgt     3360

tggtaaaata gcgctttcgc gttgcatttc tgttctgtaa aaatgcagct cagattcttt     3420

gtttgaaaaa ttagcgctct cgcgttgcat ttttgttcta caaaatgaag cacagatgct     3480

tcgttcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta     3540

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata     3600

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc     3660

ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga     3720

agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct     3780

tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg     3840

tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta     3900

ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat     3960

gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt     4020

acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga     4080

tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga     4140

gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga     4200

actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc     4260

aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc     4320

cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg     4380

tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat     4440

cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata     4500

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct     4560

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga     4620

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg     4680

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc     4740

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct     4800

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc     4860

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt     4920

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg     4980

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct     5040

atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag     5100

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag     5160

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg     5220

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg     5280

gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac     5340

cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt     5400

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat     5460

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc     5520

aattaatgtg agttacctca ctcattaggc accccaggct ttacacttta tgcttccggc     5580

tcctatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca     5640

tgattacgcc aagcgcgcaa ttaaccctca ctaaagggaa caaaagctgg agctccaccg     5700

cggatagatc tagttcgagt ttatcattat caatactgcc atttcaaaga atacgtaaat     5760

aattaatagt agtgattttc ctaactttat ttagtcaaaa aattagcctt ttaattctgc     5820

tgtaacccgt acatgcccaa aatagggggc gggttacaca gaatatataa catcgtaggt     5880

gtctgggtga acagtttatt cctggcatcc actaaatata atggagcccg ctttttaagc     5940

tggcatccag aaaaaaaaag aatcccagca ccaaaatatt gttttcttca ccaaccatca     6000

gttcataggt ccattctctt agcgcaacta cagagaacag gggcacaaac aggcaaaaaa     6060

cgggcacaac ctcaatggag tgatgcaacc tgcctggagt aaatgatgac acaaggcaat     6120

tgacccacgc atgtatctat ctcattttct tacaccttct attaccttct gctctctctg     6180

atttggaaaa agctgaaaaa aaaggttgaa accagttccc tgaaattatt cccctacttg     6240

actaataagt atataaagac ggtaggtatt gattgtaatt ctgtaaatct atttcttaaa     6300

cttcttaaat tctactttta tagttagtct tttttttagt tttaaaacac caagaactta     6360

gtttcgaata aacacacata aacgctgagg atgacaacag attactcatc accagcatat     6420

ttgcaaaaag ttgataagta ctggcgtgct gccaactact tatcagttgg tcaactttat     6480

ttaaaagata atccactatt acaacggcca ttgaaggcca gtgacgttaa ggttcatcca     6540

attggtcact gggggacgat tgccggtcaa aactttatct atgctcatct taaccgggtc     6600

atcaacaagt acggtttgaa gatgttctac gttgaaggtc caggtcatgg tggtcaagtg     6660

atggtttcaa actcttacct tgacggtact tacaccgata tttatccaga aattacgcag     6720

gatgttgaag ggatgcaaaa gctcttcaag caattctcat tcccaggtgg ggttgcttcc     6780

catgcggcac ctgaaacacc cggttcaatc cacgaaggtg gcgaacttgg ttactcaatt     6840

tcacacgggg ttggggcaat tcttgacaat cctgacgaaa tcgccgcggt tgttgttggt     6900

gatggggaat ccgaaacggg tccattagca acttcatggc aatcaacgaa gttcattaac     6960

ccaatcaacg acggggctgt tttaccaatc ttgaacttaa atggttttaa gatttctaat     7020

ccaacgattt ttggtcggac ttctgatgct aagattaagg aatacttcga aagcatgaat     7080

tgggaaccaa tcttcgttga aggtgacgat cctgaaaagg ttcacccagc cttagctaag     7140

gccatggatg aagccgttga aaagatcaag gcaatccaga agcatgctcg cgaaaataac     7200

gatgcaacat tgccagtatg gccaatgatc gtcttccgcg cacctaaggg ctggactggt     7260

ccgaagtcat gggacggtga taagatcgaa ggttcattcc gtgctcatca aattccgatt     7320

cctgttgatc aaaatgacat ggaacatgcg gatgctttag ttgattggct cgaatcatat     7380

caaccaaaag aactcttcaa tgaagatggc tctttgaagg atgatattaa agaaattatt     7440

cctactgggg acagtcggat ggctgctaac ccaatcacca atggtggggt cgatccgaaa     7500

gccttgaact taccaaactt ccgtgattat gcggtcgata cgtccaaaga aggcgcgaat     7560

gttaagcaag atatgatcgt ttggtcagac tatttgcggg atgtcatcaa gaaaaatcct     7620

gataacttcc ggttgttcgg acctgatgaa accatgtcta accgtttata tggtgtcttc     7680

gaaaccacta atcgtcaatg gatggaagac attcatccag atagtgacca atatgaagca     7740

ccagctggcc gggtcttaga tgctcagtta tctgaacacc aagctgaagg ttggttagaa     7800

ggttacgtct taactggacg tcatgggtta tttgccagtt atgaagcctt cctacgcgtt     7860

gtggactcaa tgttgacgca acacttcaag tggttacgta aagccaatga acttgattgg     7920

cgtaaaaagt acccatcact taacattatc gcggcttcaa ctgtattcca acaagaccat     7980

aatggttata cccaccaaga tccaggtgca ttaactcatt tggccgaaaa gaaaccagaa     8040

tacattcgtg aatatttacc agccgatgcc aacacgttat tagctgtcgg tgacgtcatt     8100

ttccggagcc aagaaaagat caactacgtg gttacgtcaa aacacccacg tcaacaatgg     8160

ttcagcattg aagaagctaa gcaattagtt gacaatggtc ttggtatcat tgattgggca     8220

agtacggacc aaggtagcga accagacatt gtctttgcag ctgctgggac ggaaccaacg     8280

cttgaaacgt tggctgccat ccaattacta cacgacagtt tcccagagat gaagattcgt     8340

ttcgtgaacg tggtcgacat cttgaagtta cgtagtcctg aaaaggatcc gcggggcttg     8400

tcagatgctg agtttgacca ttactttact aaggacaaac cagtggtctt tgctttccac     8460

ggttacgaag acttagttcg tgacatcttc tttgatcgtc acaaccataa cttatacgtc     8520

cacggttacc gtgaaaatgg tgatattacc acaccattcg acgtacgggt catgaaccag     8580

atggaccgct tcgacttagc taagtcggca attgcggcgc aaccagcaat ggaaaacact     8640

ggtgcggcct tcgttcaatc catggataat atgcttgcta aacacaatgc ctatatccgg     8700

gatgccggaa ctgacttgcc agaagttaat gattggcaat ggaagggttt aaaataatta     8760

attaatcatg taattagtta tgtcacgctt acattcacgc cctcctccca catccgctct     8820

aaccgaaaag gaaggagtta gacaacctga agtctaggtc cctatttatt ttttttaata     8880

gttatgttag tattaagaac gttatttata tttcaaattt ttcttttttt tctgtacaaa     8940

cgcgtgtacg catgtaacat tatactgaaa accttgcttg agaaggtttt gggacgctcg     9000

aaggctttaa tttgcgggcg gccgctctag aactagtacc acaggtgttg tcctctgagg     9060

acataaaata cacaccgaga ttcatcaact cattgctgga gttagcatat ctacaattgg     9120

gtgaaatggg gagcgatttg caggcatttg ctcggcatgc cggtagaggt gtggtcaata     9180

agagcgacct catgctatac ctgagaaagc aacctgacct acaggaaaga gttactcaag     9240

aataagaatt ttcgttttaa aacctaagag tcactttaaa atttgtatac acttattttt     9300

tttataactt atttaataat aaaaatcata aatcataaga aattcgctta ctcttaatta     9360

attaagctaa tccttgggct gctgtaataa tcgcaacctt ataaacgtct tcttcactgc     9420

atccacgtga caagtcggag accggcttgt tcaggccttg caagacagga cccaccgctt     9480

caaaatgacc aaatcgttgc gcaatcttat agccaatatt accagactga agctctggaa     9540

atacaaagac attggcatga ccagctactt tggaaccagg agccttttgc aaaccaactt     9600

tttcaacgaa ggccgcgtca aattgaagtt caccatcgat agccaattcc ggttcagcag     9660

cttgcgcctt ggccgttgct tcttgcactt tagtgaccat ttcaccctta gccgaaccct     9720

tagttgagaa gctgagcatc gcaactttcg ggtcaatatc gaagacctta gcagtagccg     9780

cactctgagt ggcaatttcc gctaacgtat cggcatcggg atcaatattg atggcacagt     9840

cagcaaagac gtagcgttcc tcaccctttt gcatgataaa tgcacccgag attcggtgtg     9900

aaccgggctt ggtcttaata atttgtaacg ctggccgtac cgtatcacca gttggatgga     9960

ttgcacctga aaccatccca tccgctttgc ccatataaac gagcatcgtg ccaaagtagt    10020

tttcatcttc cagcatttta gccgcttgtt ctggcgtatt cttacctttc cgccgttcaa    10080

cgagggcatc aagcattgct tgcttatctt cagccgggta tgtcgcagga tcaaggactt    10140

gaacgcctgt taaatccgca ttcaaatcgt tagccacagc ctgaactttg tccgttgcac    10200

ctaaaacaat cggcttaacc aagccgtctg cagctaatcg cgctgccgca ccgacaattc    10260

ggggttcagt tccttcaggg aaaacaattg tttgatcttt accagtaatt ttttgtgcta    10320

atgactcaaa taaatccatc ctcagcgaga tagttgattg tatgcttggt atagcttgaa    10380

atattgtgca gaaaaagaaa caaggaagaa agggaacgag aacaatgacg aggaaacaaa    10440

agattaataa ttgcaggtct atttatactt gatagcaaga cagcaaactt ttttttattt    10500

caaattcaag taactggaag gaaggccgta taccgttgct cattagagag tagtgtgcgt    10560

gaatgaagga aggaaaaagt ttcgtgtgct tcgagatacc cctcatcagc tctggaacaa    10620

cgacatctgt tggtgctgtc tttgtcgtta attttttcct ttagtgtctt ccatcatttt    10680

tttgtcattg cggatatggt gagacaacaa cgggggagag agaaaagaaa aaaaaagaaa    10740

agaagttgca tgcgcctatt attacttcaa tagatggcaa atggaaaaag ggtagtgaaa    10800

cttcgatatg atgatggcta tcaagtctag ggctacagta ttagttcgtt atgtaccacc    10860

atcaatgagg cagtgtaatt ggtgtagtct tgtttagccc attatgtctt gtctggtatc    10920

tgttctattg tatatctccc ctccgccacc tacatgttag ggagaccaac gaaggtatta    10980

taggaatccc gatgtatggg tttggttgcc agaaaag                             11017


