                               SEQUENCE LISTING

<110> Yale University
 
<120> INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTORS AND METHODS OF USE 
      THEREOF

<130> 117950-00620

<140> New Application
<141> 2010-12-20

<150> US 61/290789
<151> 2009-12-29

<160> 159   

<170> PatentIn version 3.3

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of ArtificialSequence: Synthetic peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Glu, Arg or Gln

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Arg or Thr

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Glu or Lys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Glu or Ala

<400> 1
Ile Xaa Arg Val Xaa Xaa Glu Asp Xaa Gly 
1               5                   10  


<210> 2
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 2
Glu Val Val Asp Lys Gly Phe Ile Asn 
1               5                   


<210> 3
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 3
Ala Ser Tyr Leu 
1               


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>

<223> Description of Artificial Sequence: Synthetic peptide

<400> 4
Thr Leu Glu Val Val 
1               5   


<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 5
Ala Ser Tyr Leu Thr Leu Glu Val Val 
1               5                   


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 6
Asp Lys Gly Arg Glu Gly 
1               5       


<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence


<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 7
Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu 
1               5                   10      


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 8
Val Thr Thr Thr Leu Glu Val Val Asp 
1               5                   


<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 9
Arg Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile 
1               5                   10          


<210> 10
<211> 4
<212> PRT
<213> Artificial Sequence


<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 10
Thr Thr Leu Glu 
1               


<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 11
Thr Thr Leu Glu Ala Ser Tyr Leu 
1               5               


<210> 12
<211> 9

<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 12
Lys Ser Glu Asn Glu Ser Asn Ile Arg 
1               5                   


<210> 13
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 13
Asn Glu Ser Asn 
1               


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 14
Ser Lys Ala Ser Tyr 
1               5   


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 15
Asn Glu Ser Asn Ser Lys Ala Ser Tyr 
1               5                   


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 16
Ala Phe Pro Lys Pro 
1               5   


<210> 17
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 17
Asn Ser Asp Val 
1               


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 18
Ala Phe Pro Lys Pro Asn Ser Asp Val 
1               5                   


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 19
Glu Ser Asn Ile Arg 
1               5   


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 20
Ala Phe Pro Lys Pro Glu Ser Asn Ile Arg 
1               5                   10  


<210> 21
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 21
Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu 
1               5                   10  




<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 22
Ile Arg Tyr Val Ser Glu Leu His Leu 
1               5                   


<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 23
Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr 
1               5                   10      



<210> 24
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 24
Gly Glu Asn Val Asp Leu Ile Val Glu Tyr Glu 
1               5                   10      


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 25
Met Asn Arg Thr Phe Thr Asp Lys Trp Glu 
1               5                   10  


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 26
Lys Trp Glu Asp Tyr 


1               5   


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 27
Val Ser Glu Leu His 
1               5   


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 28
Lys Trp Glu Asp Tyr Val Ser Glu Leu His 

1               5                   10  


<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 29
Asp Lys Trp Glu 
1               


<210> 30
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 30
Leu His Leu Thr 
1               


<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide


<400> 31
Asp Lys Trp Glu Leu His Leu Thr 
1               5               


<210> 32
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 32
His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr 
1               5                   10          


<210> 33
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 33
Met Asn Arg Thr Phe Thr Asp Lys Trp Glu His Leu Thr Arg Leu Lys 
1               5                   10                  15      


Gly Thr Glu Gly Gly Thr 
            20          


<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 34
Val Phe Val Asn Asp Gly Glu Asn Val Asp 
1               5                   10  


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 35
Val Asn Thr Lys Pro Glu Ile 
1               5           


<210> 36
<211> 8
<212> PRT

<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 36
Ala Tyr Asn Asp Val Gly Lys Thr 
1               5               


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 37
Val Asn Thr Lys Pro Glu Ile Ala Tyr Asn Asp Val Gly Lys Thr 
1               5                   10                  15  


<210> 38
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 38
Ala Gly Phe Pro Glu Pro Thr 
1               5           



<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 39
Val Asn Thr Lys Pro Glu Ile Ala Gly Phe Pro Glu Pro Thr 
1               5                   10                  



<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 40
Phe Gly Lys Leu Val 
1               5   



<210> 41
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 41
Val Asn Thr Lys Pro Glu Ile Phe Gly Lys Leu Val 
1               5                   10          


<210> 42
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 42
Val Asn Asp Gly Glu Asn 
1               5       


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 43
Val Asn Thr Lys Pro Glu Ile Val Asn Asp Gly Glu Asn 
1               5                   10              


<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 44
Arg Leu Lys Gly Thr Glu Gly 
1               5           


<210> 45
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 45
Val Asn Thr Lys Pro Glu Ile Arg Leu Lys Gly Thr Glu Gly 
1               5                   10                  


<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 46
Gly Pro Pro Phe Gly Lys Leu 
1               5           


<210> 47
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 47
Gly Thr Glu Gly Gly 
1               5   


<210> 48
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 48
Gly Pro Pro Phe Gly Lys Leu Gly Thr Glu Gly Gly 
1               5                   10          


<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 49
Val Asn Asp Gly Glu 
1               5   


<210> 50
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 50
Tyr Asn Asp Val Gly Lys 
1               5       


<210> 51
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 51
Val Asn Asp Gly Glu Tyr Asn Asp Val Gly Lys 
1               5                   10      


<210> 52
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 52
Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu 
1               5                   10      


<210> 53
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 53
Asp Arg Leu Val Asn Gly Met Leu Gln Cys 
1               5                   10  


<210> 54
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 54
Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys 
1               5                   10          


<210> 55
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 55
Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser 
1               5                   10      


<210> 56
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 56
Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln 
1               5                   10      


<210> 57
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 57
Asp Ser Ser Ala Phe Lys His Asn Gly Thr 
1               5                   10  


<210> 58
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 58
Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
1               5                   10  


<210> 59
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 59
Leu Asn Ser Ser Gly Pro Pro Phe Gly Lys Leu 
1               5                   10      


<210> 60
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 60
Phe Ala Phe Lys Gly Asn Asn Lys Glu Gln Ile 



1               5                   10      


<210> 61
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 61
Thr Lys Pro Glu Ile Leu 
1               5       


<210> 62
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 62
Val Gly Lys Thr Ser Ala 
1               5       


<210> 63
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 63
Thr Lys Pro Glu Ile Leu Val Gly Lys Thr Ser Ala 
1               5                   10          


<210> 64
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 64
Ile Leu Thr Tyr Asp Arg Leu 
1               5           


<210> 65
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide



<400> 65
Ala Tyr Phe Asn Phe Ala 
1               5       


<210> 66
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 66
Ile Leu Thr Tyr Asp Arg Leu Ala Tyr Phe Asn Phe Ala 
1               5                   10              


<210> 67
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 67
Lys His Asn Gly Thr 
1               5   


<210> 68
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 68
Ala Tyr Phe Asn Phe Ala Lys His Asn Gly Thr 
1               5                   10      


<210> 69
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 69
Gly Thr Glu Gln Arg Cys 
1               5       


<210> 70
<211> 12
<212> PRT
<213> Artificial Sequence

<220>


<223> Description of Artificial Sequence: Synthetic peptide

<400> 70
Ala Tyr Phe Asn Phe Ala Gly Thr Glu Gln Arg Cys 
1               5                   10          


<210> 71
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 71
Tyr His Arg Lys Val Arg Pro Val Ser Ser His Gly Asp Phe Asn Tyr 
1               5                   10                  15      


<210> 72
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 72
Pro Phe Val Ser 
1               


<210> 73
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 73
Lys Ala Phe Thr 
1               


<210> 74
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 74
Leu Ala Phe Lys Glu Ser Asn Ile Tyr 
1               5                   


<210> 75
<211> 8
<212> PRT
<213> Artificial Sequence


<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 75
Leu Leu Glu Val Phe Glu Phe Ile 
1               5               


<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 76
Arg Val Lys Gly Phe Pro Asp 
1               5           


<210> 77
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 77
Lys Ala Ser Asn Glu Ser 
1               5       


<210> 78
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 78
Lys Ala Glu Ser 
1               


<210> 79
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 79
Gly Thr Thr Lys Glu Lys 
1               5       


<210> 80
<211> 5



<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 80
Tyr Phe Gly Lys Leu 
1               5   


<210> 81
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 81
Phe Val Asn Asn 
1               


<210> 82
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 82
Asp Asn Thr Lys Val 
1               5   


<210> 83
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 83
Gly Gly Val Lys 
1               


<210> 84
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 84
Leu Gly Val Val 
1               




<210> 85
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide


<400> 85
Tyr Gly His Arg Lys Val Arg Pro Phe Val Ser Ser Ser His Gly Asp 
1               5                   10                  15      


Phe Asn Tyr 
            


<210> 86
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 86
Lys Ser Tyr Leu Phe Pro Lys Asn Glu Ser Asn Ile Tyr 
1               5                   10              


<210> 87
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 87
Gly Gly Gly Tyr Val Thr Phe Phe Gly Lys 
1               5                   10  


<210> 88
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 88
Asp Thr Lys Glu Ala Gly Lys 
1               5           


<210> 89
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 89
Tyr Phe Lys Leu Thr Arg Leu Glu Thr 
1               5                   


<210> 90
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 90
Glu Gly Phe Pro 
1               


<210> 91
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 91
Glu Tyr Phe Pro 
1               


<210> 92
<211> 976
<212> PRT
<213> Homo sapiens

<400> 92
Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             




Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 

    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 

                965                 970                 975     


<210> 93
<211> 972
<212> PRT
<213> Homo sapiens

<400> 93
Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 

Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 

    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Glu Gln Ile 
            500                 505                 510         


His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly Phe Val Ile Val 
        515                 520                 525             


Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr Tyr Lys Tyr Leu 
    530                 535                 540                 


Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val Glu Glu Ile Asn 
545                 550                 555                 560 


Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp His 
                565                 570                 575     


Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly 
            580                 585                 590         


Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala Tyr Gly Leu Ile 
        595                 600                 605             


Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met Leu Lys Pro Ser 
    610                 615                 620                 


Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu Leu Lys Val Leu 
625                 630                 635                 640 


Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu Leu Gly Ala Cys 
                645                 650                 655     



Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly 
            660                 665                 670         


Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser 
        675                 680                 685             


Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu His 
    690                 695                 700                 


Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp Met 
705                 710                 715                 720 


Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala Asp Lys Arg Arg 
                725                 730                 735     


Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile 
            740                 745                 750         


Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe 
        755                 760                 765             


Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala Ser Lys Asn Cys 
    770                 775                 780                 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Thr His Gly Arg 
785                 790                 795                 800 


Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Lys Asn Asp 
                805                 810                 815     


Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met 
            820                 825                 830         


Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp Val 
        835                 840                 845             


Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser 
    850                 855                 860                 


Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr Lys Met Ile Lys 
865                 870                 875                 880 


Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro Ala Glu Met Tyr 

                885                 890                 895     


Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr 
            900                 905                 910         


Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr 
        915                 920                 925             


Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys 
    930                 935                 940                 


Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val Gly Ser Thr Ala 
945                 950                 955                 960 


Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970         


<210> 94
<211> 29
<212> PRT
<213> Homo sapiens

<400> 94
Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly Thr 
1               5                   10                  15      


Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp 
            20                  25                  


<210> 95
<211> 29
<212> PRT
<213> Mus musculus

<400> 95
Asn Ile Arg Tyr Val Asn Gln Leu Arg Leu Thr Arg Leu Lys Gly Thr 
1               5                   10                  15      


Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp 
            20                  25                  


<210> 96
<211> 29
<212> PRT
<213> Gallus gallus

<400> 96
Asn Asn Ser Tyr Thr Ser Glu Leu His Leu Thr Arg Leu Lys Gly Thr 
1               5                   10                  15      



Glu Gly Gly Ile Tyr Thr Phe Phe Val Ser Asn Ser Asp 
            20                  25                  


<210> 97
<211> 29
<212> PRT
<213> Xenopus laevis


<400> 97
Asn Asn Arg Tyr Val Ser Glu Leu His Leu Ile Arg Leu Lys Gly Thr 
1               5                   10                  15      


Glu Lys Gly Ile Tyr Thr Phe Tyr Ser Ser Asn Ser Asp 
            20                  25                  


<210> 98
<211> 29
<212> PRT
<213> Ambystoma mexicanum

<400> 98
Asn Ser Arg Tyr Ile Ser Glu Leu His Leu Ile Arg Leu Lys Gly Ala 
1               5                   10                  15      


Glu Arg Gly Ile Tyr Thr Phe His Val Asp Asn Ser Asp 
            20                  25                  


<210> 99
<211> 28
<212> PRT
<213> Danio rerio

<400> 99
Asn Ser Tyr Thr Ser Glu Leu Lys Leu Val Arg Leu Lys Val Ser Glu 
1               5                   10                  15      


Ser Gly Ile Tyr Thr Phe Ser Cys Leu Asn Arg Asp 
            20                  25              


<210> 100
<211> 28
<212> PRT
<213> Danio rerio

<400> 100
Tyr Arg Tyr Ile Ser Glu Leu Arg Leu Val Arg Val His Gly Ser Glu 
1               5                   10                  15      


Gly Gly Ile Tyr Thr Phe Ser Ala Asn His Lys Tyr 
            20                  25              


<210> 101
<211> 29
<212> PRT
<213> Homo sapiens

<400> 101
Thr Tyr Arg His Thr Phe Thr Leu Ser Leu Pro Arg Leu Lys Pro Ser 
1               5                   10                  15      


Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg Asn Pro Gly 
            20                  25                  


<210> 102
<211> 29
<212> PRT
<213> Mus musculus

<400> 102
Ile Tyr Arg Tyr Thr Phe Lys Leu Phe Leu Asn Arg Val Lys Ala Ser 
1               5                   10                  15      


Glu Ala Gly Gln Tyr Phe Leu Asn Ala Gln Asn Lys Ala 
            20                  25                  


<210> 103
<211> 27
<212> PRT
<213> Takifugu rubripes

<400> 103
Ile Tyr His Ala Arg Leu Gln Leu Lys Arg Asn Asn Ala Gln Glu Gln 
1               5                   10                  15      


Gly Gln Tyr Thr Phe Tyr Ala Lys Ser Asn Leu 
            20                  25          


<210> 104
<211> 27
<212> PRT
<213> Takifugu rubripes

<400> 104
Arg Ser Glu Ala Ser Leu Leu Leu Arg Arg Val Arg Gln Glu Asp His 
1               5                   10                  15      


Gly Ser Tyr Thr Phe His Phe Ser Asn Ser Phe 
            20                  25          


<210> 105
<211> 29
<212> PRT
<213> Homo sapiens

<400> 105
Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu 
1               5                   10                  15      


Asp Ser Gly Gly His Tyr Thr Ile Val Ala Gln Asn Glu 
            20                  25                  


<210> 106
<211> 29
<212> PRT
<213> Mus musculus

<400> 106
Glu Thr Arg Tyr Gln Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu 
1               5                   10                  15      


Asp Ser Gly Gly His Tyr Thr Ile Ile Val Gln Asn Glu 
            20                  25                  


<210> 107
<211> 29
<212> PRT
<213> Homo sapiens

<400> 107
Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val Arg Val Lys Val Ala 
1               5                   10                  15      


Glu Ala Gly His Tyr Thr Met Arg Ala Phe His Glu Asp 
            20                  25                  


<210> 108
<211> 29
<212> PRT
<213> Mus musculus

<400> 108
Glu Thr Arg Tyr Val Ser Glu Leu Ile Leu Val Arg Val Lys Val Ser 
1               5                   10                  15      


Glu Ala Gly Tyr Tyr Thr Met Arg Ala Phe His Glu Asp 
            20                  25                  


<210> 109
<211> 29
<212> PRT
<213> Homo sapiens

<400> 109
Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg Val Thr Glu Glu 
1               5                   10                  15      


Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln Lys 
            20                  25                  


<210> 110
<211> 29
<212> PRT
<213> Homo sapiens

<400> 110
Leu Lys Asp Gly Asn Arg Asn Leu Thr Ile Arg Arg Val Arg Lys Glu 
1               5                   10                  15      


Asp Glu Gly Leu Tyr Thr Cys Gln Ala Cys Ser Val Leu 
            20                  25                  


<210> 111
<211> 29
<212> PRT
<213> Homo sapiens

<400> 111
Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln Arg Val Arg Glu Glu 
1               5                   10                  15      


Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn Ala Lys 
            20                  25                  


<210> 112
<211> 79
<212> PRT
<213> Homo sapiens

<400> 112
Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val Arg 
1               5                   10                  15      


Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val Lys 
            20                  25                  30          


Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn Glu 
        35                  40                  45              


Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr Cys 
    50                  55                  60                  


Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
65                  70                  75                  


<210> 113
<211> 80
<212> PRT
<213> Mus musculus

<400> 113
Pro Ser Pro Pro Ser Ile His Pro Ala Gln Ser Glu Leu Ile Val Glu 
1               5                   10                  15      


Ala Gly Asp Thr Leu Ser Leu Thr Cys Ile Asp Pro Asp Phe Val Arg 
            20                  25                  30          


Trp Thr Phe Lys Thr Tyr Phe Asn Glu Met Val Glu Asn Lys Lys Asn 
        35                  40                  45              


Glu Trp Ile Gln Glu Lys Ala Glu Ala Thr Arg Thr Gly Thr Tyr Thr 
    50                  55                  60                  


Cys Ser Asn Ser Asn Gly Leu Thr Ser Ser Ile Tyr Val Phe Val Arg 
65                  70                  75                  80  


<210> 114
<211> 85
<212> PRT
<213> Homo sapiens

<400> 114
Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val Lys 
1               5                   10                  15      


Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val Glu 
            20                  25                  30          


Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly Ser 
        35                  40                  45              


Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly Thr 
    50                  55                  60                  


Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala Ile 
65                  70                  75                  80  


His Leu Tyr Val Lys 
                85  


<210> 115
<211> 97
<212> PRT
<213> Homo sapiens

<400> 115
Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val Gln Leu 
1               5                   10                  15      


Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val Ser Trp 
            20                  25                  30          


Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile Arg Asn 
        35                  40                  45              


Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val Ser Ser 
    50                  55                  60                  


Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn His Thr 
65                  70                  75                  80  


Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile Tyr Val 
                85                  90                  95      


Pro 

    

<210> 116
<211> 91
<212> PRT
<213> Homo sapiens

<400> 116
Gln Gly Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val 
1               5                   10                  15      


Ser Ser Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp 
            20                  25                  30          


Glu Arg Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp 
        35                  40                  45              


Gly Thr Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp 
    50                  55                  60                  


Thr Gly Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr 
65                  70                  75                  80  


Asp Glu Arg Lys Arg Leu Tyr Ile Phe Val Pro 
                85                  90      


<210> 117
<211> 94
<212> PRT
<213> Homo sapiens

<400> 117
Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
1               5                   10                  15      


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
            20                  25                  30          


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
        35                  40                  45              


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
    50                  55                  60                  


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
65                  70                  75                  80  


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro 
                85                  90                  


<210> 118
<211> 94
<212> PRT
<213> Mus musculus

<400> 118
Asp Pro Ala Lys Leu Phe Leu Val Gly Leu Pro Leu Phe Gly Lys Glu 
1               5                   10                  15      


Asp Ser Asp Ala Leu Val Arg Cys Pro Leu Thr Asp Pro Gln Val Ser 
            20                  25                  30          


Asn Tyr Ser Leu Ile Glu Cys Asp Gly Lys Ser Leu Pro Thr Asp Leu 
        35                  40                  45              


Thr Phe Val Pro Asn Pro Lys Ala Gly Ile Thr Ile Lys Asn Val Lys 
    50                  55                  60                  


Arg Ala Tyr His Arg Leu Cys Val Arg Cys Ala Ala Gln Arg Asp Gly 
65                  70                  75                  80  


Thr Trp Leu His Ser Asp Lys Phe Thr Leu Lys Val Arg Ala 
                85                  90                  


<210> 119
<211> 95
<212> PRT
<213> Homo sapiens

<400> 119
Asp Pro Ala Arg Pro Trp Asn Val Leu Ala Gln Glu Val Val Val Phe 
1               5                   10                  15      


Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu Leu Thr Asp Pro Val Leu 
            20                  25                  30          


Glu Ala Gly Val Ser Leu Val Arg Val Arg Gly Arg Pro Leu Met Arg 
        35                  40                  45              


His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr Ile His Arg 
    50                  55                  60                  


Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala Leu Met Gly 
65                  70                  75                  80  


Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val Gln Lys 
                85                  90                  95  


<210> 120
<211> 87
<212> PRT
<213> Homo sapiens

<400> 120
Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp Tyr Leu Val 
1               5                   10                  15      


Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp 
            20                  25                  30          


Pro Glu Thr Pro Val Thr Leu His Asn Ser Glu Gly Val Val Pro Ala 
        35                  40                  45              


Ser Tyr Asp Ser Arg Gln Gly Phe Asn Gly Thr Phe Thr Val Gly Pro 
    50                  55                  60                  


Tyr Ile Cys Glu Ala Thr Val Lys Gly Lys Lys Phe Gln Thr Ile Pro 
65                  70                  75                  80  


Phe Asn Val Tyr Ala Leu Lys 
                85          


<210> 121
<211> 95
<212> PRT
<213> Homo sapiens

<400> 121
Asp Pro Thr Val Gly Phe Leu Pro Asn Asp Ala Glu Glu Leu Phe Ile 
1               5                   10                  15      


Phe Leu Thr Glu Ile Thr Glu Ile Thr Glu Ile Thr Ile Pro Cys Arg 
            20                  25                  30          


Val Thr Asp Pro Gln Leu Val Val Thr Leu His Glu Lys Lys Gly Asp 
        35                  40                  45              


Val Ala Leu Pro Val Pro Tyr Asp His Gln Arg Gly Phe Ser Gly Ile 
    50                  55                  60                  


Phe Glu Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr Thr Ile 
65                  70                  75                  80  


Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg Leu 
                85                  90                  95  


<210> 122
<211> 90
<212> PRT
<213> Homo sapiens

<400> 122
Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
1               5                   10                  15      


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            20                  25                  30          


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        35                  40                  45              


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    50                  55                  60                  


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
65                  70                  75                  80  


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn 
                85                  90  


<210> 123
<211> 103
<212> PRT
<213> Homo sapiens

<400> 123
Ala Phe Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu 
1               5                   10                  15      


Leu Arg Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val 
            20                  25                  30          


Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys 
        35                  40                  45              


Leu Gln Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu 
    50                  55                  60                  


Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly 
65                  70                  75                  80  


Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr 
                85                  90                  95      


Thr Thr Leu Glu Val Val Asp 
            100             


<210> 124
<211> 105
<212> PRT
<213> Mus musculus

<400> 124
Ala Ile Lys Ala Ile Pro Val Val Ser Val Pro Glu Thr Ser His Leu 
1               5                   10                  15      


Leu Lys Lys Gly Asp Thr Phe Thr Val Val Cys Thr Ile Lys Asp Val 
            20                  25                  30          


Ser Thr Ser Val Asn Ser Met Trp Leu Lys Met Asn Pro Gln Pro Gln 
        35                  40                  45              


His Ile Ala Gln Val Lys His Asn Ser Trp His Arg Gly Asp Phe Asn 
    50                  55                  60                  


Tyr Glu Arg Gln Glu Thr Leu Thr Ile Ser Ser Ala Arg Val Asp Asp 
65                  70                  75                  80  


Ser Gly Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn 
                85                  90                  95      


Val Thr Thr Thr Leu Lys Val Val Glu 
            100                 105 


<210> 125
<211> 100
<212> PRT
<213> Homo sapiens

<400> 125
Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val Pro Ala Glu Leu Val 
1               5                   10                  15      


Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys Ser Ala Ser Ser Val 
            20                  25                  30          


Asp Val Asn Phe Asp Val Phe Leu Gln His Asn Asn Thr Lys Leu Ala 
        35                  40                  45              


Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg Tyr Gln Lys Val Leu 
    50                  55                  60                  


Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His Ala Gly Asn Tyr Ser 
65                  70                  75                  80  


Cys Val Ala Ser Asn Val Gln Gly Lys His Ser Thr Ser Met Phe Phe 
                85                  90                  95      


Arg Val Val Glu 
            100 


<210> 126
<211> 102
<212> PRT
<213> Homo sapiens

<400> 126
Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val Tyr 
1               5                   10                  15      


Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn Glu 
            20                  25                  30          


Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys Gly 
        35                  40                  45              


Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val Tyr 
    50                  55                  60                  


Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr Glu 
65                  70                  75                  80  


Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys Val 
                85                  90                  95      


Thr Ile Ser Val His Glu 
            100         


<210> 127
<211> 103
<212> PRT
<213> Homo sapiens

<400> 127
Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val Val 
1               5                   10                  15      


Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn Glu 
            20                  25                  30          


Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg Leu 
        35                  40                  45              


Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile Arg 
    50                  55                  60                  


Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr Tyr 
65                  70                  75                  80  


Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys Ala 
                85                  90                  95      


Ile Asn Ile Thr Val Val Glu 
            100             


<210> 128
<211> 100
<212> PRT
<213> Homo sapiens

<400> 128
Gln Thr Pro Gln Thr Thr Leu Pro Gln Leu Phe Leu Lys Val Gly Glu 
1               5                   10                  15      


Pro Leu Trp Ile Arg Cys Lys Ala Val His Val Asn His Gly Phe Gly 
            20                  25                  30          


Leu Thr Trp Glu Leu Glu Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe 
        35                  40                  45              


Glu Met Ser Thr Tyr Ser Thr Asn Arg Thr Met Ile Arg Ile Leu Phe 
    50                  55                  60                  


Ala Phe Val Ser Ser Val Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys 
65                  70                  75                  80  


Ser Ser Ser Lys His Pro Ser Gln Ser Ala Leu Val Thr Ile Val Gly 
                85                  90                  95      


Lys Gly Phe Ile 
            100 


<210> 129
<211> 101
<212> PRT
<213> Homo sapiens

<400> 129
Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val 
1               5                   10                  15      


Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro 
            20                  25                  30          


Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp 
        35                  40                  45              


Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr 
    50                  55                  60                  


Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr 
65                  70                  75                  80  


Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe 
                85                  90                  95      


Asn Val Tyr Val Asn 
            100     


<210> 130
<211> 101
<212> PRT
<213> Mus musculus

<400> 130
Lys Gly Phe Ile Asn Ile Ser Pro Val Lys Asn Thr Thr Val Phe Val 
1               5                   10                  15      



Thr Asp Gly Glu Asn Val Asp Leu Val Val Glu Tyr Glu Ala Tyr Pro 
            20                  25                  30          


Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn Arg Thr Ser Ala Asn 
        35                  40                  45              


Lys Gly Lys Asp Tyr Val Lys Ser Asp Asn Lys Ser Asn Ile Arg Tyr 
    50                  55                  60                  


Val Asn Gln Leu Arg Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr 
65                  70                  75                  80  


Tyr Thr Phe Leu Val Ser Asn Ser Asp Ala Ser Ala Ser Val Thr Phe 
                85                  90                  95      


Asn Val Tyr Val Asn 
            100     


<210> 131
<211> 102
<212> PRT
<213> Homo sapiens

<400> 131
Ser Ala Tyr Leu Asn Leu Ser Ser Glu Gln Asn Leu Ile Gln Glu Val 
1               5                   10                  15      


Thr Val Gly Glu Gly Leu Asn Leu Lys Val Met Val Glu Ala Tyr Pro 
            20                  25                  30          


Gly Leu Gln Gly Phe Asn Trp Thr Tyr Leu Gly Pro Phe Ser Asp His 
        35                  40                  45              


Gln Pro Glu Pro Lys Leu Ala Asn Ala Thr Thr Lys Asp Thr Tyr Arg 
    50                  55                  60                  


His Thr Phe Thr Leu Ser Leu Pro Arg Leu Lys Pro Ser Glu Ala Gly 
65                  70                  75                  80  


Arg Tyr Ser Phe Leu Ala Arg Asn Pro Gly Gly Trp Arg Ala Leu Thr 
                85                  90                  95      


Phe Glu Leu Thr Leu Arg 
            100         


<210> 132
<211> 100
<212> PRT
<213> Homo sapiens

<400> 132

Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln Leu Glu Ala Val 
1               5                   10                  15      


Asn Leu His Glu Val Lys His Phe Val Val Glu Val Arg Ala Tyr Pro 
            20                  25                  30          


Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr Leu Ile Glu Asn 
        35                  40                  45              


Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln Glu Ile Arg Tyr 
    50                  55                  60                  


Arg Ser Lys Leu Lys Ile Arg Ala Lys Glu Glu Asp Ser Gly His Tyr 
65                  70                  75                  80  


Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys Ser Tyr Thr Phe Glu 
                85                  90                  95      


Leu Leu Thr Gln 
            100 


<210> 133
<211> 102
<212> PRT
<213> Homo sapiens

<400> 133
Ser Gly Tyr Val Arg Leu Leu Gly Glu Val Gly Thr Leu Gln Phe Ala 
1               5                   10                  15      


Glu Leu His Arg Ser Arg Thr Leu Gln Val Val Phe Glu Ala Tyr Pro 
            20                  25                  30          


Pro Pro Thr Val Leu Trp Phe Lys Asp Asn Arg Thr Leu Gly Asp Ser 
        35                  40                  45              


Ser Ala Gly Glu Ile Ala Leu Ser Thr Arg Asn Val Ser Glu Thr Arg 
    50                  55                  60                  


Tyr Val Ser Glu Leu Thr Leu Val Arg Val Lys Val Ala Glu Ala Gly 
65                  70                  75                  80  


His Tyr Thr Met Arg Ala Phe His Glu Asp Ala Glu Val Gln Leu Ser 
                85                  90                  95      


Phe Gln Leu Gln Ile Asn 
            100         


<210> 134
<211> 99
<212> PRT
<213> Homo sapiens

<400> 134
Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Val Asn Gly Met Leu 
1               5                   10                  15      


Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe 
            20                  25                  30          


Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser Val Leu Pro Val Asp 
        35                  40                  45              


Val Gln Thr Leu Asn Ser Ser Gly Pro Pro Phe Gly Lys Leu Val Val 
    50                  55                  60                  


Gln Ser Ser Ile Asp Ser Ser Ala Phe Lys His Asn Gly Thr Val Glu 
65                  70                  75                  80  


Cys Lys Ala Tyr Asn Asp Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe 
                85                  90                  95      


Ala Phe Lys 
            


<210> 135
<211> 99
<212> PRT
<213> Mus musculus

<400> 135
Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Ile Asn Gly Met Leu 
1               5                   10                  15      


Gln Cys Val Ala Glu Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe 
            20                  25                  30          


Cys Thr Gly Ala Glu Gln Arg Cys Thr Thr Pro Val Ser Pro Val Asp 
        35                  40                  45              


Val Gln Val Gln Asn Val Ser Val Ser Pro Phe Gly Lys Leu Val Val 
    50                  55                  60                  


Gln Ser Ser Ile Asp Ser Ser Val Phe Arg His Asn Gly Thr Val Glu 
65                  70                  75                  80  


Cys Lys Ala Ser Asn Asp Val Gly Lys Ser Ser Ala Phe Phe Asn Phe 
                85                  90                  95      


Ala Phe Lys 
            


<210> 136
<211> 104
<212> PRT
<213> Homo sapiens

<400> 136
Tyr Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly 
1               5                   10                  15      


Thr Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp 
            20                  25                  30          


Leu Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu 
        35                  40                  45              


Gln Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe 
    50                  55                  60                  


His Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His 
65                  70                  75                  80  


Asn Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser 
                85                  90                  95      


Trp Ala Phe Ile Pro Ile Ser Ala 
            100                 


<210> 137
<211> 106
<212> PRT
<213> Homo sapiens

<400> 137
Val Pro Ser Ser Ile Leu Asp Leu Val Asp Asp Glu Glu Gly Ser Thr 
1               5                   10                  15      


Gly Gly Gln Thr Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp 
            20                  25                  30          


Ile Glu Trp Met Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr 
        35                  40                  45              


Ser Trp Thr Ile Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile 
    50                  55                  60                  


Glu Ser Arg Asp Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys 
65                  70                  75                  80  


Val Glu Glu Thr Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly 
                85                  90                  95      



Ala Glu Asn Arg Glu Leu Lys Leu Val Ala 
            100                 105     


<210> 138
<211> 111
<212> PRT
<213> Homo sapiens

<400> 138
Val Pro Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly 
1               5                   10                  15      


Glu Gln Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile 
            20                  25                  30          


Ile Trp Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro 
        35                  40                  45              


Pro Thr Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr 
    50                  55                  60                  


Asn Val Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr 
65                  70                  75                  80  


Leu Arg Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu 
                85                  90                  95      


Arg Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro 
            100                 105                 110     


<210> 139
<211> 96
<212> PRT
<213> Homo sapiens

<400> 139
Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser Gln Ala Ser Cys 
1               5                   10                  15      


Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp Lys Lys Cys Ser 
            20                  25                  30          


Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu Gly Val Trp Asn 
        35                  40                  45              


Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val Ser Ser Ser Thr 
    50                  55                  60                  


Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val Lys Cys Cys Ala 
65                  70                  75                  80  


Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu Leu Asn Ser Pro 
                85                  90                  95      


<210> 140
<211> 70
<212> PRT
<213> Homo sapiens

<400> 140
Ile Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu 
1               5                   10                  15      


Val Ala Asn Leu Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro 
            20                  25                  30          


Gly Met Asp Val Leu Pro Ser His Cys Trp Ile Ser Glu Met Val Val 
        35                  40                  45              


Gln Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile 
    50                  55                  60                  


Ser Glu Gly Leu Ser Asn 
65                  70  


<210> 141
<211> 70
<212> PRT
<213> Mus musculus

<400> 141
Ile Cys Gly Asn Pro Val Thr Asp Asn Val Lys Asp Ile Thr Lys Leu 
1               5                   10                  15      


Val Ala Asn Leu Pro Asn Asp Tyr Met Ile Thr Leu Asn Tyr Val Ala 
            20                  25                  30          


Gly Met Asp Val Leu Pro Ser His Cys Trp Leu Arg Asp Met Val Ile 
        35                  40                  45              



Gln Leu Ser Leu Ser Leu Thr Thr Leu Leu Asp Lys Phe Ser Asn Ile 
    50                  55                  60                  


Ser Glu Gly Leu Ser Asn 
65                  70  


<210> 142
<211> 68
<212> PRT
<213> Homo sapiens

<400> 142
Tyr Cys Ser His Met Ile Gly Ser Gly His Leu Gln Ser Leu Gln Arg 
1               5                   10                  15      

Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln Ile Thr Phe Glu Phe 
            20                  25                  30          


Val Asp Gln Glu Gln Leu Ala Asp Pro Val Cys Tyr Leu Lys Lys Ala 
        35                  40                  45              


Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr Met Arg Phe Arg Asp 
    50                  55                  60                  


Asn Thr Pro Asn 
65              


<210> 143
<211> 60
<212> PRT
<213> Homo sapiens

<400> 143
Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 
1               5                   10                  15      


Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 
            20                  25                  30          


Asp Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 
        35                  40                  45              


Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 
    50                  55                  60  


<210> 144
<211> 69
<212> PRT
<213> Homo sapiens

<400> 144
Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val Glu 
1               5                   10                  15      


Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys Ser 
            20                  25                  30          


Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe Asn 
        35                  40                  45              


Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr Ser 
    50                  55                  60                  


Asp Cys Val Val Ser 
65                  


<210> 145
<211> 69
<212> PRT
<213> Mus musculus

<400> 145
Tyr Ser Ile Ile Asp Lys Leu Gly Lys Ile Val Asp Asp Leu Val Leu 
1               5                   10                  15      


Cys Met Glu Glu Asn Ala Pro Lys Asn Ile Lys Glu Ser Pro Lys Arg 
            20                  25                  30          


Pro Glu Thr Arg Ser Phe Thr Pro Glu Glu Phe Phe Ser Ile Phe Asn 
        35                  40                  45              


Arg Ser Ile Asp Ala Phe Lys Asp Phe Met Val Ala Ser Asp Thr Ser 
    50                  55                  60                  


Asp Cys Val Leu Ser 
65                  


<210> 146
<211> 69
<212> PRT
<213> Homo sapiens

<400> 146
Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
1               5                   10                  15      


Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Ala Ala Cys Val Arg Thr 
            20                  25                  30          


Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn Val Phe 
        35                  40                  45              


Asn Glu Thr Lys Asn Leu Leu Asp Lys Asp Ala Asn Ile Phe Ser Lys 
    50                  55                  60                  


Asn Cys Asn Asn Ser 
65                  


<210> 147
<211> 65
<212> PRT
<213> Homo sapiens

<400> 147
Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 
1               5                   10                  15      


Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 
            20                  25                  30          


Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 
        35                  40                  45              


Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 
    50                  55                  60                  


Gln 
65  


<210> 148
<211> 101
<212> PRT
<213> Homo sapiens

<400> 148
Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln Leu Glu Ala Val 
1               5                   10                  15      


Asn Leu His Glu Val Lys His Phe Val Val Glu Val Arg Ala Tyr Pro 
            20                  25                  30          



Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr Leu Ile Glu Asn 
        35                  40                  45              


Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln Glu Thr Arg Tyr 
    50                  55                  60                  


Gln Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly His 
65                  70                  75                  80  


Tyr Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys Ser Tyr Thr Phe 
                85                  90                  95      


Glu Leu Leu Thr Gln 
            100     


<210> 149
<211> 101
<212> PRT
<213> Mus musculus

<400> 149
Lys Gly Phe Val Glu Ile Glu Pro Thr Phe Gly Gln Leu Glu Ala Val 
1               5                   10                  15      


Asn Leu His Glu Val Arg Glu Phe Val Val Glu Val Gln Ala Tyr Pro 
            20                  25                  30          


Thr Pro Arg Ile Ser Trp Leu Lys Asp Asn Leu Thr Leu Ile Glu Asn 
        35                  40                  45              




Leu Thr Glu Ile Thr Thr Asp Val Gln Lys Ser Gln Glu Thr Arg Tyr 
    50                  55                  60                  


Gln Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly His 
65                  70                  75                  80  


Tyr Thr Ile Ile Val Gln Asn Glu Asp Asp Val Lys Ser Tyr Thr Phe 
                85                  90                  95      


Glu Leu Ser Thr Leu 
            100     


<210> 150
<211> 101
<212> PRT
<213> Gallus gallus

<400> 150
His Gly Phe Ile His Leu Glu Pro Gln Phe Ser Pro Leu Glu Ala Val 
1               5                   10                  15      


Asn Leu His Glu Val Lys Asn Phe Val Val Asp Val Gln Ala Tyr Pro 
            20                  25                  30          


Ala Pro Lys Met Tyr Trp Leu Lys Asp Asn Val Thr Leu Ile Glu Asn 
        35                  40                  45              


Leu Thr Glu Ile Val Thr Ser Ser Asn Arg Val Gln Glu Thr Arg Phe 
    50                  55                  60                  


Gln Ser Val Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Ile Leu Trp Leu Leu Lys Asn Glu Asp Glu Ile Lys Arg Tyr Thr Phe 
                85                  90                  95      


Ser Leu Leu Ile Gln 
            100     


<210> 151
<211> 101
<212> PRT
<213> Rana sp.

<400> 151
Lys Gly Phe Ile Asp Leu Glu Pro Met Phe Gly Ser Glu Glu Phe Ala 
1               5                   10                  15      


Asn Leu His Glu Val Lys Ser Phe Ile Val Asn Leu His Ala Tyr Pro 
            20                  25                  30          



Thr Pro Gly Leu Phe Trp Leu Lys Asp Asn Arg Thr Leu Ser Glu Asn 
        35                  40                  45              


Leu Thr Glu Ile Thr Thr Ser Ile Val Thr Thr Lys Glu Thr Arg Phe 
    50                  55                  60                  


Gln Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly Leu 
65                  70                  75                  80  


Tyr Thr Leu Val Ala Gln Asn Asp Arg Glu Thr Lys Ser Tyr Ser Phe 
                85                  90                  95      


Ile Leu Gln Ile Lys 
            100     


<210> 152
<211> 101
<212> PRT
<213> Takifugu rubripes

<400> 152
Ser Glu Phe Met Ser Ile Gln Pro Lys Phe Gly Glu Tyr Glu Ser Ala 
1               5                   10                  15      



Glu Leu Asp Glu Val Cys Glu Phe Arg Ala Glu Ile Thr Ser Phe Pro 
            20                  25                  30          


Thr Ala Ser Val Thr Trp Phe Lys Asp Ser Val Pro Leu Ser Asn Val 
        35                  40                  45              


Thr Ala Glu Ile Ser Thr Ser Leu Gln Lys Leu Ser Glu Thr Ser Tyr 
    50                  55                  60                  


Met Ser Val Leu Thr Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly Asn 
65                  70                  75                  80  


Tyr Thr Met Arg Val Lys Asn Gly Asp Gln Ser Arg Thr Val Ser Leu 
                85                  90                  95      


Ile Leu Glu Val Lys 
            100     


<210> 153
<211> 102
<212> PRT
<213> Homo sapiens

<400> 153
Ser Gly Tyr Val Arg Leu Leu Gly Glu Val Gly Thr Leu Gln Phe Ala 
1               5                   10                  15      

Glu Leu His Arg Ser Arg Thr Leu Gln Val Val Phe Glu Ala Tyr Pro 
            20                  25                  30          


Pro Pro Thr Val Leu Trp Phe Lys Asp Asn Arg Thr Leu Gly Asp Ser 
        35                  40                  45              


Ser Ala Gly Glu Ile Ala Leu Ser Thr Arg Asn Val Ser Glu Thr Arg 
    50                  55                  60                  


Tyr Val Ser Glu Leu Thr Leu Val Arg Val Lys Val Ala Glu Ala Gly 
65                  70                  75                  80  


His Tyr Thr Met Arg Ala Phe His Glu Asp Ala Glu Val Gln Leu Ser 
                85                  90                  95      


Phe Gln Leu Gln Ile Asn 
            100         


<210> 154
<211> 102
<212> PRT
<213> Canis familiaris

<400> 154
Ser Gly Tyr Val Arg Leu Leu Gly Glu Leu Asp Ala Val Gln Phe Ala 
1               5                   10                  15      


Glu Leu His Arg Ser Arg Ala Leu Gln Val Val Phe Glu Ala Tyr Pro 
            20                  25                  30          


Pro Pro Thr Val Val Trp Phe Lys Asp Asn Arg Thr Leu Gly Asp Ser 
        35                  40                  45              


Ser Ala Gly Glu Ile Ala Leu Ser Thr Arg Asn Val Ser Glu Thr Arg 
    50                  55                  60                  


Tyr Val Ser Glu Leu Thr Leu Val Arg Val Lys Val Ala Glu Ala Gly 
65                  70                  75                  80  


Tyr Tyr Thr Met Arg Ala Phe His Glu Asp Ala Glu Ala Gln Leu Ser 
                85                  90                  95      


Phe Gln Leu Gln Val Asn 
            100         


<210> 155
<211> 102
<212> PRT
<213> Mus musculus

<400> 155
Asn Gly Tyr Val Arg Leu Leu Glu Thr Leu Gly Asp Val Glu Ile Ala 
1               5                   10                  15      


Glu Leu His Arg Ser Arg Thr Leu Arg Val Val Phe Glu Ala Tyr Pro 
            20                  25                  30          


Met Pro Ser Val Leu Trp Leu Lys Asp Asn Arg Thr Leu Gly Asp Ser 
        35                  40                  45              


Gly Ala Gly Glu Leu Val Leu Ser Thr Arg Asn Met Ser Glu Thr Arg 
    50                  55                  60                  


Tyr Val Ser Glu Leu Ile Leu Val Arg Val Lys Val Ser Glu Ala Gly 
65                  70                  75                  80  


Tyr Tyr Thr Met Arg Ala Phe His Glu Asp Asp Glu Val Gln Leu Ser 
                85                  90                  95      


Phe Lys Leu Gln Val Asn 
            100         


<210> 156
<211> 98
<212> PRT
<213> Takifugu rubripes

<400> 156
Arg Gly Phe Val Ala Val Lys Ser Thr Arg Lys Gln Asn Ile Thr Ala 
1               5                   10                  15      


Glu Leu Gln Glu Asn Val Glu Leu Arg Val Glu Ile Glu Ala Tyr Pro 
            20                  25                  30          


Pro Pro Gln Ile Arg Trp Lys Lys Asp Gly Ala Pro Val Arg Gly Asp 
        35                  40                  45              


Lys Thr Ile Ile Ile Arg Gln Glu His Glu Ile Arg Tyr Val Thr Ile 
    50                  55                  60                  


Leu Thr Leu Val Arg Val Arg Thr Glu Gln Lys Gly Leu Tyr Thr Ala 
65                  70                  75                  80  


Leu Ile Thr Asn Glu Asp Asp Val Lys Glu Val Thr Phe Ala Leu Glu 
                85                  90                  95      


Val Gln 
        


<210> 157
<211> 101
<212> PRT
<213> Homo sapiens

<400> 157
Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val 
1               5                   10                  15      


Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro 
            20                  25                  30          


Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp 

        35                  40                  45              


Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr 
    50                  55                  60                  


Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr 
65                  70                  75                  80  


Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe 
                85                  90                  95      


Asn Val Tyr Val Asn 
            100     



<210> 158
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Leu or Ile

<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Hydrophobic amino acid

<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> Any Amino acid

<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Any Amino acid

<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Asp or Glu

<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Any amino acid

<400> 158
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Gly 
1               5                   10  



<210> 159
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide


<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Leu or Ile

<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Arg, Gln, Glu or Asp

<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Val

<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> Arg, Lys or Thr

<220>
<221> MISC_FEATURE
<222> (6)..(6)
<223> Lys, Glu, Gln or Val

<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Glu or Val

<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Asp or Glu

<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Glu, Gly, Ser or Gln

<400> 159
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Gly 
1               5                   10  











