                               SEQUENCE LISTING	

<110> IMMUNOMEDICS, INC.
 
<120> NOVEL CLASS OF MONOSPECIFIC AND BISPECIFIC HUMANIZED ANTIBODIES 
      THAT TARGET THE INSULIN-LIKE GROWTH FACTOR TYPE I RECEPTOR 
      (IGF-1R)

<130> IMM316WO2

<140>
<141>

<150> PCT/US2010/021345
<151> 2010-01-19

<150> 61/145,896
<151> 2009-01-20

<160> 55    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Mus muscaris

<400> 1
Asp Tyr Tyr Met Tyr 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Mus muscaris

<400> 2
Tyr Ile Thr Asn Tyr Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210> 3
<211> 12
<212> PRT
<213> Mus muscaris

<400> 3
Gln Ser Asn Tyr Asp Tyr Asp Gly Trp Phe Ala Tyr 
1               5                   10          


<210> 4
<211> 11
<212> PRT
<213> Mus muscaris

<400> 4
Lys Ala Ser Gln Glu Val Gly Thr Ala Val Ala 
1               5                   10      


<210> 5
<211> 7
<212> PRT
<213> Mus muscaris

<400> 5
Trp Ala Ser Thr Arg His Thr 
1               5           


<210> 6
<211> 9
<212> PRT
<213> Mus muscaris

<400> 6
Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
1               5                   


<210> 7
<211> 121
<212> PRT
<213> Mus muscaris

<400> 7
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Tyr Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Arg Ser Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Ser Asn Tyr Asp Tyr Asp Gly Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 8
<211> 108
<212> PRT
<213> Mus muscaris

<400> 8
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Glu Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Ala Lys Leu Glu Leu Lys Arg 
            100                 105             


<210> 9
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Tyr Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Ser Asn Tyr Asp Tyr Asp Gly Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210> 10
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Glu Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 11
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
ccgcggtcac atggcaccac ctctcttgca gcttccacca agggccc                     47


<210> 12
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
ccggccgtcg cactcattta cccagagaca ggg                                    33


<210> 13
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
gagtccaaat atggtccccc atgcccaccg tgcccaggta agccaaccca gg               52


<210> 14
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
cctgggttgg cttacctggg cacggtgggc atgggggacc atatttggac tctgca           56


<210> 15
<211> 44
<212> PRT
<213> Homo sapiens 

<400> 15
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 16
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
gaacctcgcg gacagttaag                                                   20


<210> 20
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ggatcctccg ccgccgcagc tcttaggttt cttgtccacc ttggtgttgc tgg              53


<210> 21
<211> 55
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Ile Gln Ile 
1               5                   10                  15      


Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr Thr Val Glu Val Leu 
            20                  25                  30          


Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala Val Glu Tyr Phe Thr 
        35                  40                  45              


Arg Leu Arg Glu Ala Arg Ala 
    50                  55  


<210> 22
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
ggatccggag gtggcgggtc tggcggaggt ggcagccaga tcgagtacct ggccaagcag       60

atcgtggaca acgccatcca gcaggcctga cggccg                                 96


<210> 23
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
cggccgtcag gcctgctgga tggcgttgtc cacgatctgc ttggccaggt actcgatctg       60

gctgccacct ccgccagacc cgccacctcc ggatcc                                 96


<210> 24
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
ggatccggag gtggcgggtc tggcggaggt                                        30


<210> 25
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
cggccgtcag gcctgctgga tg                                                22


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Gly Gly Gly Gly Ser Gly Gly Gly Cys Gly 
1               5                   10  


<210> 27
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
gatccggagg tggcgggtct ggcggaggtt gcggccacat ccagatcccg ccggggctca       60

cggagctgct gca                                                          73


<210> 28
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
gcagctccgt gagccccggc gggatctgga tgtggccgca acctccgcca gacccgccac       60

ctccg                                                                   65


<210> 29
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gatccggagg tggcgggtct ggcggatgtg gccagatcga gtacctggcc aagcagatcg       60

tggacaacgc catccagcag gccggctgct gaa                                    93


<210> 30
<211> 89
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
ttcagcagcc ggcctgctgg atggcgttgt ccacgatctg cttggccagg tactcgatct       60

ggccacatcc gccagacccg ccacctccg                                         89


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   


<210> 32
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
agatctggcg cacctgaact cctg                                              24


<210> 33
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
gaattcggat cctttacccg gagacaggga gag                                    33


<210> 34
<211> 92
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
gtggcgggtc tggcggaggt ggcagccaca tccagatccc gccggggctc acggagctgc       60

tgcagggcta cacggtggag gtgctgcgac ag                                     92


<210> 35
<211> 92
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
gcgcgagctt ctctcaggcg ggtgaagtac tccactgcga attcgacgag gtcaggcggc       60

tgctgtcgca gcacctccac cgtgtagccc tg                                     92


<210> 36
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
ggatccggag gtggcgggtc tggcggaggt                                        30


<210> 37
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
cggccgtcaa gcgcgagctt ctctcaggcg                                        30


<210> 38
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Glu Tyr 
1               5                   10                  15      


Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln Ala 
            20                  25                  


<210> 39
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp Tyr Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Gln Ile Glu Tyr Lys Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 41
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Gln Ile Glu Tyr His Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 43
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala Val Ile Glu 
1               5                   10                  15      


Gln Val Lys Ala Ala Gly Ala Tyr 
            20                  


<210> 44
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Leu Glu Gln Tyr Ala Asn Gln Leu Ala Asp Gln Ile Ile Lys Glu Ala 
1               5                   10                  15      


Thr Glu 
        


<210> 45
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser Asp Val 
1               5                   10                  15      


Phe Gln Gln Cys 
            20  


<210> 46
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 47
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Pro Glu Asp Ala Glu Leu Val Arg Thr Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 48
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Asp Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 49
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Cys Gly Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser 
1               5                   10                  15      


Asp Val Phe Gln Gln Gly Cys 
            20              


<210> 50
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
1               5                   10                  15      


Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
            20                  25                  30          


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
        35                  40                  45              


Ala Lys 
    50  


<210> 51
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
His His His His His His 
1               5       


<210> 52
<211> 15
<212> PRT
<213> Mus muscaris

<400> 52
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15  


<210> 53
<211> 15
<212> PRT
<213> Mus muscaris

<400> 53
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
1               5                   10                  15  


<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Gly Gly Gly Gly Ser 
1               5   


<210> 55
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


