                         SEQUENCE LISTING

<110>  Jung, Gundram
       Grosse-Hovest, Ludger
       Buehring, Hans-Joerg
       Aulwurm, Steffen 
 
<120>  ANTI-CD133 ANTIBODIES AND METHODS OF USING THE SAME

<130>  P43265

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 VL CDR1

<400>  1

Thr Ala Ser Ser Ser Val Ser Ser Phe Tyr Leu His 
1               5                   10          


<210>  2
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 VL CDR2

<400>  2

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  3
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 VL CDR3

<400>  3

His Gln Tyr His Arg Ser Pro Tyr Met Tyr Met 
1               5                   10      


<210>  4
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 VH CDR1

<400>  4

Ser Gly Tyr Tyr Trp Ser 
1               5       


<210>  5
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 VH CDR2

<400>  5

Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  6
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 VH CDR3

<400>  6

Val Tyr Phe Gly His Pro Tyr Tyr Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  7
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 VL CDR1

<400>  7

Lys Ala Ser Glu Asn Val Asp Thr Tyr Val Ser 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 VL CDR2

<400>  8

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 VL CDR3

<400>  9

Gly Gln Ser Tyr Arg Tyr Pro Leu Thr 
1               5                   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 VH CDR1

<400>  10

Asn Tyr Tyr Val His 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 VH CDR2

<400>  11

Tyr Val Asp Pro Phe Asn Gly Asp Phe Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 VH CDR3

<400>  12

Gly Gly Leu Asp Trp Tyr Asp Thr Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  13
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 VL VJ Segment

<400>  13

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Phe 
            20                  25                  30          


Tyr Leu His Trp Tyr Arg Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Tyr Met Tyr Met Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110     


<210>  14
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 VH VDJ Segment

<400>  14

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Ser Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Val Tyr Phe Gly His Pro Tyr Tyr Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ile Ser Val Thr Val 
        115                 120 


<210>  15
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  15

Met Leu Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser Val 
1               5                   10                  15      


Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser 
        35                  40                  45              


Ser Val Ser Ser Phe Tyr Leu His Trp Tyr Arg Gln Lys Pro Gly Ser 
    50                  55                  60                  


Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln 
            100                 105                 110         


Tyr His Arg Ser Pro Tyr Met Tyr Met Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Cys Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  16
<211>  476
<212>  PRT
<213>  Mus musculus

<400>  16

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Leu 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Ile Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Thr Arg Val Tyr Phe Gly His Pro Tyr Tyr Tyr Gly Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Ile Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr 
            180                 185                 190         


Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser 
225                 230                 235                 240 


Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His 
                245                 250                 255     


Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe 
            260                 265                 270         


Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
    290                 295                 300                 


Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
305                 310                 315                 320 


His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro 
                325                 330                 335     


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
            340                 345                 350         


Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile 
        355                 360                 365             


Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala 
    370                 375                 380                 


Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly 
385                 390                 395                 400 


Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr 
                405                 410                 415     


Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys 
        435                 440                 445             


Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr 
    450                 455                 460                 


Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys 
465                 470                 475     


<210>  17
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  293AC1C3B9 VL VJ Segment CDS

<400>  17
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctggggga gcgggtcacc       60

atgacctgca ctgccagctc aagtgtaagt tccttttact tgcactggta ccggcagaag      120

ccagggtctt cccccaaact ctggatttat agcacatcca acctggcttc tggagttcca      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgccac cagtatcatc gttccccgta catgtacatg      300

ttcggagggg ggaccaagct agaaataaaa cgg                                   333


<210>  18
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  293AC1C3B9 VH VDJ Segment CDS

<400>  18
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt attggagctg gatccggcag      120

tttccaggaa acaaactgga atggatgggc tacataagct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagattttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attattgtac aagagtctac      300

tttggtcacc cttattacta tggtatggac tactggggtc aaggaatctc agtcaccgtc      360

tcttca                                                                 366


<210>  19
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  19
atgctgcagg tgcagatttt cagcttcctg ctaatcagtg cctcagtcat aatgtccaga       60

ggacaaattg ttctcaccca gtctccagca atcatgtctg catctctggg ggagcgggtc      120

accatgacct gcactgccag ctcaagtgta agttcctttt acttgcactg gtaccggcag      180

aagccagggt cttcccccaa actctggatt tatagcacat ccaacctggc ttctggagtt      240

ccagctcgct tcagtggcag tgggtctggg acctcttact ctctcacaat cagcagcatg      300

gaggctgaag atgctgccac ttattactgc caccagtatc atcgttcccc gtacatgtac      360

atgttcggag gggggaccaa gctagaaata aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagtga gcagttaaca tctgggtgtg cctcagtcgt gtgcttcttg      480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttag         717


<210>  20
<211>  937
<212>  DNA
<213>  Mus musculus

<400>  20
atgctgcagg tgcagatttt cagcttcctg ctaatcagtg cctcagtcat aatgtccaga       60

ggacaaattg ttctcaccca gtctccagca atcatgtctg catctctggg ggagcgggtc      120

accatgacct gcactgccag ctcaagtgta agttcctttt acttgcactg gtaccggcag      180

aagccagggt cttcccccaa actctggatt tatagcacat ccaacctggc ttctggagtt      240

ccagctcgct tcagtggcag tgggtctggg acctcttact ctctcacaat cagcagcatg      300

gaggctgaag atgctgccac ttattactgc caccagtatc atcgttcccc gtacatgtac      360

atgttcggag gggggaccaa gctagaaata aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagtga gcagttaaca tctgggtgtg cctcagtcgt gtgcttcttg      480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttagaga      720

caaaggtcct gagacgccac caccagctcc ccagctccat cctatcttcc cttctaaggt      780

cttggaggct tccccacaag cgacctacca ctgttgcggt gctccaaacc tcctccccac      840

ctccttctcc tcctcctccc tttccttggc ttttatcatg ctaatatttg cagaaaatat      900

tcaataaagt gagtctttgc acttgaaaaa aaaaaaa                               937


<210>  21
<211>  1431
<212>  DNA
<213>  Mus musculus

<400>  21
atgaaagtgt tgagtctgtt gtacctgttg acagccattc ctggtctcct gtctgatgta       60

cagcttcagg agtcaggacc tggcctcgtg aaaccttctc agtctctgtc tctcacctgc      120

tctgtcactg gctactccat caccagtggt tattattgga gctggatccg gcagtttcca      180

ggaaacaaac tggaatggat gggctacata agctacgacg gtagcaataa ctacaaccca      240

tctctcaaaa atcgaatctc catcactcgt gacacatcta agaaccagat tttcctgaag      300

ttgaattctg tgactactga ggacacagct acatattatt gtacaagagt ctactttggt      360

cacccttatt actatggtat ggactactgg ggtcaaggaa tctcagtcac cgtctcttca      420

gccaaaacaa cacccccatc agtctatcca ctggcccctg ggtgtggaga tacaactggt      480

tcctccgtga ctctgggatg cctggtcaag ggctacttcc ctgagtcagt gactgtgact      540

tggaactctg gatccctgtc cagcagtgtg cacaccttcc cagctctcct gcagtctgga      600

ctctacacta tgagcagctc agtgactgtc ccctccagca cttggccaag tcagaccgtc      660

acctgcagcg ttgctcaccc agccagcagc accacggtgg acaaaaaact tgagcccagc      720

gggcccattt caacaatcaa cccctgtcct ccatgcaagg agtgtcacaa atgcccagct      780

cctaacctcg agggtggacc atccgtcttc atcttccctc caaatatcaa ggatgtactc      840

atgatctccc tgacacccaa ggtcacgtgt gtggtggtgg atgtgagcga ggatgaccca      900

gacgtccaga tcagctggtt tgtgaacaac gtggaagtac acacagctca gacacaaacc      960

catagagagg attacaacag tactatccgg gtggtcagca ccctccccat ccagcaccag     1020

gactggatga gtggcaagga gttcaaatgc aaggtcaaca acaaagacct cccatcaccc     1080

atcgagagaa ccatctcaaa aattaaaggg ctagtcagag ctccacaagt atacatcttg     1140

ccgccaccag cagagcagtt gtccaggaaa gatgtcagtc tcacttgcct ggtcgtgggc     1200

ttcaaccctg gagacatcag tgtggagtgg accagcaatg ggcatacaga ggagaactac     1260

aaggacaccg caccagtcct ggactctgac ggttcttact tcatatatag caagctcaat     1320

atgaaaacaa gcaagtggga gaaaacagat tccttctcat gcaacgtgag acacgagggt     1380

ctgaaaaatt actacctgaa gaagaccatc tcccggtctc cgggtaaatg a              1431


<210>  22
<211>  1569
<212>  DNA
<213>  Mus musculus

<400>  22
gggtgttgcc taaaggatga aagtgttgag tctgttgtac ctgttgacag ccattcctgg       60

tctcctgtct gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc      120

tctgtctctc acctgctctg tcactggcta ctccatcacc agtggttatt attggagctg      180

gatccggcag tttccaggaa acaaactgga atggatgggc tacataagct acgacggtag      240

caataactac aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa      300

ccagattttc ctgaagttga attctgtgac tactgaggac acagctacat attattgtac      360

aagagtctac tttggtcacc cttattacta tggtatggac tactggggtc aaggaatctc      420

agtcaccgtc tcttcagcca aaacaacacc cccatcagtc tatccactgg cccctgggtg      480

tggagataca actggttcct ccgtgactct gggatgcctg gtcaagggct acttccctga      540

gtcagtgact gtgacttgga actctggatc cctgtccagc agtgtgcaca ccttcccagc      600

tctcctgcag tctggactct acactatgag cagctcagtg actgtcccct ccagcacttg      660

gccaagtcag accgtcacct gcagcgttgc tcacccagcc agcagcacca cggtggacaa      720

aaaacttgag cccagcgggc ccatttcaac aatcaacccc tgtcctccat gcaaggagtg      780

tcacaaatgc ccagctccta acctcgaggg tggaccatcc gtcttcatct tccctccaaa      840

tatcaaggat gtactcatga tctccctgac acccaaggtc acgtgtgtgg tggtggatgt      900

gagcgaggat gacccagacg tccagatcag ctggtttgtg aacaacgtgg aagtacacac      960

agctcagaca caaacccata gagaggatta caacagtact atccgggtgg tcagcaccct     1020

ccccatccag caccaggact ggatgagtgg caaggagttc aaatgcaagg tcaacaacaa     1080

agacctccca tcacccatcg agagaaccat ctcaaaaatt aaagggctag tcagagctcc     1140

acaagtatac atcttgccgc caccagcaga gcagttgtcc aggaaagatg tcagtctcac     1200

ttgcctggtc gtgggcttca accctggaga catcagtgtg gagtggacca gcaatgggca     1260

tacagaggag aactacaagg acaccgcacc agtcctggac tctgacggtt cttacttcat     1320

atatagcaag ctcaatatga aaacaagcaa gtgggagaaa acagattcct tctcatgcaa     1380

cgtgagacac gagggtctga aaaattacta cctgaagaag accatctccc ggtctccggg     1440

taaatgagct cagcacccac aaagctctca ggtcctaaga gacactggca cccatatcca     1500

tgcatccctt gtataaataa agcatccagc aaagcctggt accatgtaaa aaaaaaaaaa     1560

aaaaaaaaa                                                             1569


<210>  23
<211>  237
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 chimeric kappa light chain

<400>  23

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Gly Ala Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Ser Phe Tyr Leu His Trp Tyr Arg Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr 
            100                 105                 110         


His Arg Ser Pro Tyr Met Tyr Met Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  24
<211>  714
<212>  DNA
<213>  Artificial

<220>
<223>  293AC1C3B9 chimeric kappa light chain CDS

<400>  24
atggttttca cacctcagat acttggactt atgctttttt ggatttcagg tgctcgagga       60

caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctggggga gcgggtcacc      120

atgacctgca ctgccagctc aagtgtaagt tccttttact tgcactggta ccggcagaag      180

ccagggtctt cccccaaact ctggatttat agcacatcca acctggcttc tggagttcca      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcatggag      300

gctgaagatg ctgccactta ttactgccac cagtatcatc gttccccgta catgtacatg      360

ttcggagggg ggaccaagct agaaataaaa cggactgtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttag            714


<210>  25
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  293AC1C3B9 chimeric IgG gamma 1 heavy chain

<400>  25

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Phe Pro Gly Asn Lys 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Ile Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Val Tyr Phe Gly His Pro Tyr Tyr Tyr Gly Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ile Ser Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  26
<211>  1419
<212>  DNA
<213>  Artificial

<220>
<223>  293AC1C3B9 chimeric IgG gamma 1 heavy chain CDS

<400>  26
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctccgat       60

gtacagcttc aggagtcagg acctggcctc gtgaaacctt ctcagtctct gtctctcacc      120

tgctctgtca ctggctactc catcaccagt ggttattatt ggagctggat ccggcagttt      180

ccaggaaaca aactggaatg gatgggctac ataagctacg acggtagcaa taactacaac      240

ccatctctca aaaatcgaat ctccatcact cgtgacacat ctaagaacca gattttcctg      300

aagttgaatt ctgtgactac tgaggacaca gctacatatt attgtacaag agtctacttt      360

ggtcaccctt attactatgg tatggactac tggggtcaag gaatctcagt caccgtctct      420

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgtctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggcccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt atcgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatgataa                            1419


<210>  27
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  SDIE 293AC1C3B9 heavy chain

<400>  27

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Phe Pro Gly Asn Lys 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Ile Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Val Tyr Phe Gly His Pro Tyr Tyr Tyr Gly Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ile Ser Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  28
<211>  1419
<212>  DNA
<213>  Artificial

<220>
<223>  SDIE 293AC1C3B9 heavy chain CDS

<400>  28
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctccgat       60

gtacagcttc aggagtcagg acctggcctc gtgaaacctt ctcagtctct gtctctcacc      120

tgctctgtca ctggctactc catcaccagt ggttattatt ggagctggat ccggcagttt      180

ccaggaaaca aactggaatg gatgggctac ataagctacg acggtagcaa taactacaac      240

ccatctctca aaaatcgaat ctccatcact cgtgacacat ctaagaacca gattttcctg      300

aagttgaatt ctgtgactac tgaggacaca gctacatatt attgtacaag agtctacttt      360

ggtcaccctt attactatgg tatggactac tggggtcaag gaatctcagt caccgtctct      420

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgtctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggcccggatg tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt atcgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccgagga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatgataa                            1419


<210>  29
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 VL VJ Segment

<400>  29

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Asp Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Ser Leu Thr Ile Ser Asn Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  30
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 VH VDJ Segment

<400>  30

Glu Ile Gln Leu Gln Gln Ser Gly Pro Asp Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val His Trp Val Lys Gln Ser Leu Asp Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Asp Pro Phe Asn Gly Asp Phe Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Asp Trp Tyr Asp Thr Ser Tyr Trp Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser 
        115                 120                 


<210>  31
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  31

Met Glu Ser Gln Thr Leu Val Phe Ile Ser Ile Leu Leu Trp Leu Tyr 
1               5                   10                  15      


Gly Ala Asp Gly Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser 
            20                  25                  30          


Met Ser Leu Gly Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn 
        35                  40                  45              


Val Asp Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro 
    50                  55                  60                  


Lys Val Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr 
            100                 105                 110         


Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  32
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 IgG gamma 1 heavy chain mouse

<400>  32

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Ile Gln Leu Gln Gln Ser Gly Pro Asp Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asn Tyr Tyr Val His Trp Val Lys Gln Ser Leu Asp Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Val Asp Pro Phe Asn Gly Asp Phe Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Leu Asp Trp Tyr Asp Thr Ser Tyr Trp 
        115                 120                 125             


Tyr Phe Asp Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala 
145                 150                 155                 160 


Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
        195                 200                 205             


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr 
    210                 215                 220                 


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
225                 230                 235                 240 


Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
                245                 250                 255     


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            260                 265                 270         


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        275                 280                 285             


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        355                 360                 365             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    370                 375                 380                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
385                 390                 395                 400 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                405                 410                 415     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            420                 425                 430         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  33
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  W6B3H10 VL VJ Segment CDS

<400>  33
aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cacttggaga gagggtcacc       60

ttgagctgca aggccagtga gaatgtggat acttatgtat cctggtatca acagaaacca      120

gagcagtctc ctaaagtgtt gatatacggg gcatccaacc ggtacactgg ggtccccgat      180

cgcttcacag gcagtggatc tgcaacagat ttctctctga ccatcagcaa tgtacaggct      240

gaagaccttg cagattatca ctgtggacag agttacaggt atcccctcac gttcggtgct      300

gggaccaagt tggagctgaa acgg                                             324


<210>  34
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  W6B3H10 VH VDJ Segment CDS

<400>  34
gagatccaac tacagcagtc tggacctgac ctgatgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact aactactacg tgcactgggt gaagcagagc      120

cttgacaaga gccttgagtg gattggatat gttgatcctt tcaatggtga ttttaactac      180

aaccagaaat tcaaggacaa ggccacattg actgtagaca aatcttccag cacagcctac      240

atgcatctca gcagcctgac atctgaggac tctgcagtct attactgtgc cagaggggga      300

cttgactggt atgatacctc ctactggtac ttcgatgtct ggggcgcagg gaccgcggtc      360

accgtctcct ca                                                          372


<210>  35
<211>  705
<212>  DNA
<213>  Mus musculus

<400>  35
atggaatcac agactctggt cttcatatcc atactgctct ggttatatgg tgctgatgga       60

aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cacttggaga gagggtcacc      120

ttgagctgca aggccagtga gaatgtggat acttatgtat cctggtatca acagaaacca      180

gagcagtctc ctaaagtgtt gatatacggg gcatccaacc ggtacactgg ggtccccgat      240

cgcttcacag gcagtggatc tgcaacagat ttctctctga ccatcagcaa tgtacaggct      300

gaagaccttg cagattatca ctgtggacag agttacaggt atcccctcac gttcggtgct      360

gggaccaagt tggagctgaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      705


<210>  36
<211>  941
<212>  DNA
<213>  Mus musculus

<400>  36
cagcatgggc atcaagatgg aatcacagac tctggtcttc atatccatac tgctctggtt       60

atatggtgct gatggaaaca ttgtaatgac ccaatctccc aaatccatgt ccatgtcact      120

tggagagagg gtcaccttga gctgcaaggc cagtgagaat gtggatactt atgtatcctg      180

gtatcaacag aaaccagagc agtctcctaa agtgttgata tacggggcat ccaaccggta      240

cactggggtc cccgatcgct tcacaggcag tggatctgca acagatttct ctctgaccat      300

cagcaatgta caggctgaag accttgcaga ttatcactgt ggacagagtt acaggtatcc      360

cctcacgttc ggtgctggga ccaagttgga gctgaaacgg gctgatgctg caccaactgt      420

atccatcttc ccaccatcca gtgagcagtt aacatctgga ggtgcctcag tcgtgtgctt      480

cttgaacaac ttctacccca aagacatcaa tgtcaagtgg aagattgatg gcagtgaacg      540

acaaaatggc gtcctgaaca gttggactga tcaggacagc aaagacagca cctacagcat      600

gagcagcacc ctcacgttga ccaaggacga gtatgaacga cataacagct atacctgtga      660

ggccactcac aagacatcaa cttcacccat tgtcaagagc ttcaacagga atgagtgtta      720

gagacaaagg tcctgagacg ccaccaccag ctccccagct ccatcctatc ttcccttcta      780

aggtcttgga ggcttcccca caagcgacct accactgttg cggtgctcca aacctcctcc      840

ccacctcctt ctcctcctcc tccctttcct tggcttttat catgctaata tttgcagaaa      900

atattcaata aagtgagtct ttgcacttga aaaaaaaaaa a                          941


<210>  37
<211>  1404
<212>  DNA
<213>  Mus musculus

<400>  37
atgggatgga gctggatctt tctcttcctt ctgtcaggaa ctgcaggtgt ccactctgag       60

atccaactac agcagtctgg acctgacctg atgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttactc attcactaac tactacgtgc actgggtgaa gcagagcctt      180

gacaagagcc ttgagtggat tggatatgtt gatcctttca atggtgattt taactacaac      240

cagaaattca aggacaaggc cacattgact gtagacaaat cttccagcac agcctacatg      300

catctcagca gcctgacatc tgaggactct gcagtctatt actgtgccag agggggactt      360

gactggtatg atacctccta ctggtacttc gatgtctggg gcgcagggac cgcggtcacc      420

gtctcctcag ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc      480

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg      540

acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg      600

cagtctgacc tctacactct gagcagctca gtgactgtcc cctccagcac ctggcccagc      660

gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga caagaaaatt      720

gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc      780

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      840

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      900

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      960

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa     1020

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1080

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1140

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1200

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1260

gatggctctt acttcgtcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1320

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1380

ctctcccact ctcctggtaa atga                                            1404


<210>  38
<211>  1563
<212>  DNA
<213>  Mus musculus

<400>  38
gtcctcgcca cagtccctgc agacactgac tctaaccatg ggatggagct ggatctttct       60

cttccttctg tcaggaactg caggtgtcca ctctgagatc caactacagc agtctggacc      120

tgacctgatg aagcctgggg cttcagtgaa gatatcctgc aaggcttctg gttactcatt      180

cactaactac tacgtgcact gggtgaagca gagccttgac aagagccttg agtggattgg      240

atatgttgat cctttcaatg gtgattttaa ctacaaccag aaattcaagg acaaggccac      300

attgactgta gacaaatctt ccagcacagc ctacatgcat ctcagcagcc tgacatctga      360

ggactctgca gtctattact gtgccagagg gggacttgac tggtatgata cctcctactg      420

gtacttcgat gtctggggcg cagggaccgc ggtcaccgtc tcctcagcca aaacgacacc      480

cccatctgtc tatccactgg cccctggatc tgctgcccaa actaactcca tggtgaccct      540

gggatgcctg gtcaagggct atttccctga gccagtgaca gtgacctgga actctggatc      600

cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag tctgacctct acactctgag      660

cagctcagtg actgtcccct ccagcacctg gcccagcgag accgtcacct gcaacgttgc      720

ccacccggcc agcagcacca aggtggacaa gaaaattgtg cccagggatt gtggttgtaa      780

gccttgcata tgtacagtcc cagaagtatc atctgtcttc atcttccccc caaagcccaa      840

ggatgtgctc accattactc tgactcctaa ggtcacgtgt gttgtggtag acatcagcaa      900

ggatgatccc gaggtccagt tcagctggtt tgtagatgat gtggaggtgc acacagctca      960

gacgcaaccc cgggaggagc agttcaacag cactttccgc tcagtcagtg aacttcccat     1020

catgcaccag gactggctca atggcaagga gttcaaatgc agggtcaaca gtgcagcttt     1080

ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc agaccgaagg ctccacaggt     1140

gtacaccatt ccacctccca aggagcagat ggccaaggat aaagtcagtc tgacctgcat     1200

gataacagac ttcttccctg aagacattac tgtggagtgg cagtggaatg ggcagccagc     1260

ggagaactac aagaacactc agcccatcat ggacacagat ggctcttact tcgtctacag     1320

caagctcaat gtgcagaaga gcaactggga ggcaggaaat actttcacct gctctgtgtt     1380

acatgagggc ctgcacaacc accatactga gaagagcctc tcccactctc ctggtaaatg     1440

atcccagtgt ccttggagcc ctctggtcct acaggactct gacacctacc tccacccctc     1500

cctgtataaa taaagcaccc agcactgcct tgggaccctg caaaaaaaaa aaaaaaaaaa     1560

aaa                                                                   1563


<210>  39
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 chimeric kappa light chain

<400>  39

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Gly Ala Arg Gly Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser 
            20                  25                  30          


Met Ser Leu Gly Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn 
        35                  40                  45              


Val Asp Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro 
    50                  55                  60                  


Lys Val Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr 
            100                 105                 110         


Arg Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  40
<211>  705
<212>  DNA
<213>  Artificial

<220>
<223>  W6B3H10 chimeric kappa light chain CDS

<400>  40
atggttttca cacctcagat acttggactt atgctttttt ggatttcagg tgctcgagga       60

aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cacttggaga gagggtcacc      120

ttgagctgca aggccagtga gaatgtggat acttatgtat cctggtatca acagaaacca      180

gagcagtctc ctaaagtgtt gatatacggg gcatccaacc ggtacactgg ggtccccgat      240

cgcttcacag gcagtggatc tgcaacagat ttctctctga ccatcagcaa tgtacaggct      300

gaagaccttg cagattatca ctgtggacag agttacaggt atcccctcac gttcggtgct      360

gggaccaagt tggagctgaa acggactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      705


<210>  41
<211>  473
<212>  PRT
<213>  Artificial

<220>
<223>  W6B3H10 chimeric IgG gamma 1 heavy chain

<400>  41

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Ile Gln Leu Gln Gln Ser Gly Pro Asp Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asn Tyr Tyr Val His Trp Val Lys Gln Ser Leu Asp Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Val Asp Pro Phe Asn Gly Asp Phe Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Leu Asp Trp Tyr Asp Thr Ser Tyr Trp 
        115                 120                 125             


Tyr Phe Asp Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  42
<211>  1425
<212>  DNA
<213>  Artificial

<220>
<223>  W6B3H10 chimeric IgG gamma 1 heavy chain CDS

<400>  42
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctccgag       60

atccaactac agcagtctgg acctgacctg atgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttactc attcactaac tactacgtgc actgggtgaa gcagagcctt      180

gacaagagcc ttgagtggat tggatatgtt gatcctttca atggtgattt taactacaac      240

cagaaattca aggacaaggc cacattgact gtagacaaat cttccagcac agcctacatg      300

catctcagca gcctgacatc tgaggactct gcagtctatt actgtgccag agggggactt      360

gactggtatg atacctccta ctggtacttc gatgtctggg gcgcagggac cgcggtcacc      420

gtctcctcag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      480

acctctgggg gcacagcggc cctgggctgt ctggtcaagg actacttccc cgaaccggtg      540

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      720

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      780

ctggggggcc cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      840

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      900

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      960

cagtacaaca gcacgtatcg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1020

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1080

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1140

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1260

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1320

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1380

cactacacgc agaagagcct ctccctgtct ccgggtaaat gataa                     1425


<210>  43
<211>  473
<212>  PRT
<213>  Artificial

<220>
<223>  SDIE W6B3H10 heavy chain

<400>  43

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Ile Gln Leu Gln Gln Ser Gly Pro Asp Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asn Tyr Tyr Val His Trp Val Lys Gln Ser Leu Asp Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Val Asp Pro Phe Asn Gly Asp Phe Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Leu Asp Trp Tyr Asp Thr Ser Tyr Trp 
        115                 120                 125             


Tyr Phe Asp Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  44
<211>  1425
<212>  DNA
<213>  Artificial

<220>
<223>  SDIE W6B3H10 heavy chain CDS

<400>  44
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctccgag       60

atccaactac agcagtctgg acctgacctg atgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttactc attcactaac tactacgtgc actgggtgaa gcagagcctt      180

gacaagagcc ttgagtggat tggatatgtt gatcctttca atggtgattt taactacaac      240

cagaaattca aggacaaggc cacattgact gtagacaaat cttccagcac agcctacatg      300

catctcagca gcctgacatc tgaggactct gcagtctatt actgtgccag agggggactt      360

gactggtatg atacctccta ctggtacttc gatgtctggg gcgcagggac cgcggtcacc      420

gtctcctcag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      480

acctctgggg gcacagcggc cctgggctgt ctggtcaagg actacttccc cgaaccggtg      540

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      720

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      780

ctggggggcc cggatgtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      840

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      900

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      960

cagtacaaca gcacgtatcg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1020

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc cgaggagaaa     1080

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1140

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1260

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1320

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1380

cactacacgc agaagagcct ctccctgtct ccgggtaaat gataa                     1425


<210>  45
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer gamma1-for

<400>  45
caaggcttac aaccacaatc cctgg                                             25


<210>  46
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer gamma1-back

<400>  46
catatgtaca gtcccagaag tatcatctg                                         29


<210>  47
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer gamma2b-for

<400>  47
ggaggacagg ggttgattgt tgaaatgggc c                                      31


<210>  48
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer gamma2b-rev

<400>  48
caaggagtgt cacaaatgcc cagctcctaa cc                                     32


<210>  49
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer Ck-for

<400>  49
tgttcaagaa gcacacgact gaggcacctc c                                      31


<210>  50
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer Ck-back

<400>  50
acttctaccc caaagacatc aatgtcaag                                         29


<210>  51
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer k-for1

<400>  51
cctgttgaag ctcttgacaa tggg                                              24


<210>  52
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer k-for2

<400>  52
atgtcttgtg agtggcctca cagg                                              24


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer CG1-for1

<400>  53
cgtctacagc aagctcaatg tgc                                               23


<210>  54
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer CG1-for2

<400>  54
ccatctgtct atccactggc c                                                 21


<210>  55
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer CG1-rev1

<400>  55
ccaggtcact gtcactggct cag                                               23


<210>  56
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer CG1-rev2

<400>  56
cctcatgtaa cacagagcag g                                                 21


<210>  57
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 2b-Seq1

<400>  57
gagtggcaag gagttcaaat gc                                                22


<210>  58
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 2b-Seq2

<400>  58
catgcaacgt gagacacgag gg                                                22


<210>  59
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 2b-Seq3

<400>  59
cggaggaacc agttgtatct cc                                                22


<210>  60
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 2b-Seq4

<400>  60
cccggagacc gggagatggt cttc                                              24


<210>  61
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer W6B3-H-hin

<400>  61
ctgtctttct cttcacaggt gtcctctccg agatccaact acagcagtct ggacctgacc       60


<210>  62
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer W6B3-H-rev

<400>  62
tagaatggga gaaggtagga ctcacctgag gagacggtga ccgcggtccc tgcgccccag       60


<210>  63
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 293-H-hin

<400>  63
ctgtctttct cttcacaggt gtcctctccg atgtacagct tcaggagtca ggacctggcc       60


<210>  64
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 293-H-rev

<400>  64
tagaatggga gaaggtagga ctcacctgaa gagacggtga ctgagattcc ttgaccccag       60


<210>  65
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer universal for (AatII)

<400>  65
agacgtccac tctgtctttc tcttcacagg tgtcctctcc                             40


<210>  66
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer universal rev (ClaI)

<400>  66
tatcgattta gaatgggaga aggtaggact cac                                    33


<210>  67
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer W6B3-kappa-hin (XhoI)

<400>  67
actcgaggag acattgtaat gacccaatct cccaaatcca tgtcc                       45


<210>  68
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer W6B3-kappa-rev (SpeI)

<400>  68
tactagtact tacgtttcag ctccaacttg gtcccagcac cgaacgtgag g                51


<210>  69
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 293-kappa-hin (XhoI)

<400>  69
actcgaggac aaattgttct cacccagtct ccagcaatca tg                          42


<210>  70
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer 293-kappa-rev (SpeI)

<400>  70
tactagtact tacgttttat ttctagcttg gtcccccctc cgaacatg                    48


<210>  71
<211>  846
<212>  PRT
<213>  Homo sapiens

<400>  71

Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp Asn Tyr Glu 
1               5                   10                  15      


Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys Ala Gly Pro 
            20                  25                  30          


Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr Val Val Gln 
        35                  40                  45              


Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu Gln Lys Ala 
    50                  55                  60                  


Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val Ile Leu Gly 
65                  70                  75                  80  


Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys Cys Val Leu 
                85                  90                  95      


Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr Phe Phe Cys 
            100                 105                 110         


Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His Gln Arg Gln 
        115                 120                 125             


Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu 
    130                 135                 140                 


Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala 
145                 150                 155                 160 


Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp 
                165                 170                 175     


Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln 
            180                 185                 190         


Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe 
        195                 200                 205             


Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly Ile Leu Asp 
    210                 215                 220                 


Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile Lys Ser Met 
225                 230                 235                 240 


Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn Met Asn Ser 
                245                 250                 255     


Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu 
            260                 265                 270         


Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys 
        275                 280                 285             


Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu 
    290                 295                 300                 


Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro Pro Val Asp 
305                 310                 315                 320 


Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp Leu Asp Gly 
                325                 330                 335     


Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro Asp Arg Val 
            340                 345                 350         


Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg Val Leu Asn 
        355                 360                 365             


Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu Pro Ile Gln 
    370                 375                 380                 


Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr 
385                 390                 395                 400 


Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp 
                405                 410                 415     


Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile Val Ile Phe 
            420                 425                 430         


Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp Arg His Ala 
        435                 440                 445             


Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly Val Phe Leu 
    450                 455                 460                 


Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile Leu Met Ile 
465                 470                 475                 480 


Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu Lys Leu Ile 
                485                 490                 495     


Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu Asp Thr Pro 
            500                 505                 510         


Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe 
        515                 520                 525             


Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys 
    530                 535                 540                 


Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln Asn Ser Phe 
545                 550                 555                 560 


Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly Ser Ile Ser 
                565                 570                 575     


Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe Leu Leu Gly 
            580                 585                 590         


Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp 
        595                 600                 605             


Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala 
    610                 615                 620                 


Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn 
625                 630                 635                 640 


Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln 
                645                 650                 655     


Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile Glu Gln Ser 
            660                 665                 670         


Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg Thr Gly Asn 
        675                 680                 685             


Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala 
    690                 695                 700                 


Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile Glu Glu Thr 
705                 710                 715                 720 


Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln 
                725                 730                 735     


Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys Lys Pro Val 
            740                 745                 750         


Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys Ser Tyr Ile 
        755                 760                 765             


Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys Ala Thr Val 
    770                 775                 780                 


Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr 
785                 790                 795                 800 


Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu Thr Ile Pro 
                805                 810                 815     


Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys Asp His Val 
            820                 825                 830         


Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln His 
        835                 840                 845     


