                         SEQUENCE LISTING

<110>  Webb, Bradley T
 
<120>  RISK FACTORS OF CIGARETTE SMOKE-INDUCED SPIROMETRIC 
       PHENOTYPESRISK FACTORS OF CIGARETTE SMOKE-INDUCED SPIROMETRIC 
       PHENOTYPES

<130>  01881.8006

<150>  US 61/295,555
<151>  2005-01-15

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  1284
<212>  DNA
<213>  Homo sapiens

<400>  1
ctgtgattct cactatactg gtcctgagga aagggcttct gtgaactgcg gtttttagtt       60

tttattgtgg ttcttagttc tcatgagacc cctcttgagg atatgtgcct atctggtgcc      120

tctgctctcc actagttgag tgaaaggaag gaggtaattt accaccatgt ttggttcctg      180

tttataagat gttttaagaa agatctgaaa cagattttct gaagaaagca gaagctctct      240

tcccattatg acttcggaaa tcacttatgc tgaagtgagg ttcaaaaatg aattcaagtc      300

ctcaggcatc aacacagcct cttctgcagc ttccaaggag aggactgccc ctcacaaaag      360

taataccgga ttccccaagc tgctttgtgc ctcactgttg atatttttcc tgctattggc      420

aatctcattc tttattgctt ttgtcatttt ctttcaaaaa tattctcagc ttcttgaaaa      480

aaagactaca aaagagctgg ttcatacaac attggagtgt gtgaaaaaaa atatgcccgt      540

ggaagagaca gcctggagct gttgcccaaa gaattggaag tcatttagtt ccaactgcta      600

ctttatttct actgaatcag catcttggca agacagtgag aaggactgtg ctagaatgga      660

ggctcacctg ctggtgataa acactcaaga agagcaggat ttcatcttcc agaatctgca      720

agaagaatct gcttattttg tggggctctc agatccagaa ggtcagcgac attggcaatg      780

ggttgatcag acaccataca atgaaagttc cacattctgg catccacgtg agcccagtga      840

tcccaatgag cgctgcgttg tgctaaattt tcgtaaatca cccaaaagat ggggctggaa      900

tgatgttaat tgtcttggtc ctcaaaggtc agtttgtgag atgatgaaga tccacttatg      960

aactgaacat tctccatgaa caggtggttg gattggtatc tgtcattgta gggatagata     1020

ataagctctt cttattcatg tgtaagggag gtccatagaa tttaggtggt ctgtcaacta     1080

ttctacttat gagagaattg gtctgtacat tgactgattc actttttcat aaagtgagca     1140

tttattgagc attttttcat gtgccagagc ctgtactgga ggcccccatt gtgcacacat     1200

ggagagaaca tgagtctctc ttaattttta tctggttgct aaagaattat ttaccaataa     1260

aattatatga tgtggtgtct caaa                                            1284


<210>  2
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ser Glu Ile Thr Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Thr Ala Ser Ser Ala Ala Ser Lys Glu Arg 
            20                  25                  30          


Thr Ala Pro His Lys Ser Asn Thr Gly Phe Pro Lys Leu Leu Cys Ala 
        35                  40                  45              


Ser Leu Leu Ile Phe Phe Leu Leu Leu Ala Ile Ser Phe Phe Ile Ala 
    50                  55                  60                  


Phe Val Ile Phe Phe Gln Lys Tyr Ser Gln Leu Leu Glu Lys Lys Thr 
65                  70                  75                  80  


Thr Lys Glu Leu Val His Thr Thr Leu Glu Cys Val Lys Lys Asn Met 
                85                  90                  95      


Pro Val Glu Glu Thr Ala Trp Ser Cys Cys Pro Lys Asn Trp Lys Ser 
            100                 105                 110         


Phe Ser Ser Asn Cys Tyr Phe Ile Ser Thr Glu Ser Ala Ser Trp Gln 
        115                 120                 125             


Asp Ser Glu Lys Asp Cys Ala Arg Met Glu Ala His Leu Leu Val Ile 
    130                 135                 140                 


Asn Thr Gln Glu Glu Gln Asp Phe Ile Phe Gln Asn Leu Gln Glu Glu 
145                 150                 155                 160 


Ser Ala Tyr Phe Val Gly Leu Ser Asp Pro Glu Gly Gln Arg His Trp 
                165                 170                 175     


Gln Trp Val Asp Gln Thr Pro Tyr Asn Glu Ser Ser Thr Phe Trp His 
            180                 185                 190         


Pro Arg Glu Pro Ser Asp Pro Asn Glu Arg Cys Val Val Leu Asn Phe 
        195                 200                 205             


Arg Lys Ser Pro Lys Arg Trp Gly Trp Asn Asp Val Asn Cys Leu Gly 
    210                 215                 220                 


Pro Gln Arg Ser Val Cys Glu Met Met Lys Ile His Leu 
225                 230                 235         


<210>  3
<211>  1167
<212>  DNA
<213>  Homo sapiens

<400>  3
ctgtgattct cactatactg gtcctgagga aagggcttct gtgaactgcg gtttttagtt       60

tttattgtgg ttcttagttc tcatgagacc cctcttgagg atatgtgcct atctggtgcc      120

tctgctctcc actagttgag tgaaaggaag gaggtaattt accaccatgt ttggttcctg      180

tttataagat gttttaagaa agatctgaaa cagattttct gaagaaagca gaagctctct      240

tcccattatg acttcggaaa tcacttatgc tgaagtgagg ttcaaaaatg aattcaagtc      300

ctcaggcatc aacacagcct cttctgcagt tttctttcaa aaatattctc agcttcttga      360

aaaaaagact acaaaagagc tggttcatac aacattggag tgtgtgaaaa aaaatatgcc      420

cgtggaagag acagcctgga gctgttgccc aaagaattgg aagtcattta gttccaactg      480

ctactttatt tctactgaat cagcatcttg gcaagacagt gagaaggact gtgctagaat      540

ggaggctcac ctgctggtga taaacactca agaagagcag gatttcatct tccagaatct      600

gcaagaagaa tctgcttatt ttgtggggct ctcagatcca gaaggtcagc gacattggca      660

atgggttgat cagacaccat acaatgaaag ttccacattc tggcatccac gtgagcccag      720

tgatcccaat gagcgctgcg ttgtgctaaa ttttcgtaaa tcacccaaaa gatggggctg      780

gaatgatgtt aattgtcttg gtcctcaaag gtcagtttgt gagatgatga agatccactt      840

atgaactgaa cattctccat gaacaggtgg ttggattggt atctgtcatt gtagggatag      900

ataataagct cttcttattc atgtgtaagg gaggtccata gaatttaggt ggtctgtcaa      960

ctattctact tatgagagaa ttggtctgta cattgactga ttcacttttt cataaagtga     1020

gcatttattg agcatttttt catgtgccag agcctgtact ggaggccccc attgtgcaca     1080

catggagaga acatgagtct ctcttaattt ttatctggtt gctaaagaat tatttaccaa     1140

taaaattata tgatgtggtg tctcaaa                                         1167


<210>  4
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Ser Glu Ile Thr Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Thr Ala Ser Ser Ala Val Phe Phe Gln Lys 
            20                  25                  30          


Tyr Ser Gln Leu Leu Glu Lys Lys Thr Thr Lys Glu Leu Val His Thr 
        35                  40                  45              


Thr Leu Glu Cys Val Lys Lys Asn Met Pro Val Glu Glu Thr Ala Trp 
    50                  55                  60                  


Ser Cys Cys Pro Lys Asn Trp Lys Ser Phe Ser Ser Asn Cys Tyr Phe 
65                  70                  75                  80  


Ile Ser Thr Glu Ser Ala Ser Trp Gln Asp Ser Glu Lys Asp Cys Ala 
                85                  90                  95      


Arg Met Glu Ala His Leu Leu Val Ile Asn Thr Gln Glu Glu Gln Asp 
            100                 105                 110         


Phe Ile Phe Gln Asn Leu Gln Glu Glu Ser Ala Tyr Phe Val Gly Leu 
        115                 120                 125             


Ser Asp Pro Glu Gly Gln Arg His Trp Gln Trp Val Asp Gln Thr Pro 
    130                 135                 140                 


Tyr Asn Glu Ser Ser Thr Phe Trp His Pro Arg Glu Pro Ser Asp Pro 
145                 150                 155                 160 


Asn Glu Arg Cys Val Val Leu Asn Phe Arg Lys Ser Pro Lys Arg Trp 
                165                 170                 175     


Gly Trp Asn Asp Val Asn Cys Leu Gly Pro Gln Arg Ser Val Cys Glu 
            180                 185                 190         


Met Met Lys Ile His Leu 
        195             


<210>  5
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  5
ctgtgattct cactatactg gtcctgagga aagggcttct gtgaactgcg gtttttagtt       60

tttattgtgg ttcttagttc tcatgagacc cctcttgagg atatgtgcct atctggtgcc      120

tctgctctcc actagttgag tgaaaggaag gaggtaattt accaccatgt ttggttcctg      180

tttataagat gttttaagaa agatctgaaa cagattttct gaagaaagca gaagctctct      240

tcccattatg acttcggaaa tcacttatgc tgaagtgagg ttcaaaaatg aattcaagtc      300

ctcaggcatc aacacagcct cttctgcaga gacagcctgg agctgttgcc caaagaattg      360

gaagtcattt agttccaact gctactttat ttctactgaa tcagcatctt ggcaagacag      420

tgagaaggac tgtgctagaa tggaggctca cctgctggtg ataaacactc aagaagagca      480

ggatttcatc ttccagaatc tgcaagaaga atctgcttat tttgtggggc tctcagatcc      540

agaaggtcag cgacattggc aatgggttga tcagacacca tacaatgaaa gttccacatt      600

ctggcatcca cgtgagccca gtgatcccaa tgagcgctgc gttgtgctaa attttcgtaa      660

atcacccaaa agatggggct ggaatgatgt taattgtctt ggtcctcaaa ggtcagtttg      720

tgagatgatg aagatccact tatgaactga acattctcca tgaacaggtg gttggattgg      780

tatctgtcat tgtagggata gataataagc tcttcttatt catgtgtaag ggaggtccat      840

agaatttagg tggtctgtca actattctac ttatgagaga attggtctgt acattgactg      900

attcactttt tcataaagtg agcatttatt gagcattttt tcatgtgcca gagcctgtac      960

tggaggcccc cattgtgcac acatggagag aacatgagtc tctcttaatt tttatctggt     1020

tgctaaagaa ttatttacca ataaaattat atgatgtggt gtctcaaa                  1068


<210>  6
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Ser Glu Ile Thr Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Thr Ala Ser Ser Ala Glu Thr Ala Trp Ser 
            20                  25                  30          


Cys Cys Pro Lys Asn Trp Lys Ser Phe Ser Ser Asn Cys Tyr Phe Ile 
        35                  40                  45              


Ser Thr Glu Ser Ala Ser Trp Gln Asp Ser Glu Lys Asp Cys Ala Arg 
    50                  55                  60                  


Met Glu Ala His Leu Leu Val Ile Asn Thr Gln Glu Glu Gln Asp Phe 
65                  70                  75                  80  


Ile Phe Gln Asn Leu Gln Glu Glu Ser Ala Tyr Phe Val Gly Leu Ser 
                85                  90                  95      


Asp Pro Glu Gly Gln Arg His Trp Gln Trp Val Asp Gln Thr Pro Tyr 
            100                 105                 110         


Asn Glu Ser Ser Thr Phe Trp His Pro Arg Glu Pro Ser Asp Pro Asn 
        115                 120                 125             


Glu Arg Cys Val Val Leu Asn Phe Arg Lys Ser Pro Lys Arg Trp Gly 
    130                 135                 140                 


Trp Asn Asp Val Asn Cys Leu Gly Pro Gln Arg Ser Val Cys Glu Met 
145                 150                 155                 160 


Met Lys Ile His Leu 
                165 


<210>  7
<211>  1185
<212>  DNA
<213>  Homo sapiens

<400>  7
ctgtgattct cactatactg gtcctgagga aagggcttct gtgaactgcg gtttttagtt       60

tttattgtgg ttcttagttc tcatgagacc cctcttgagg atatgtgcct atctggtgcc      120

tctgctctcc actagttgag tgaaaggaag gaggtaattt accaccatgt ttggttcctg      180

tttataagat gttttaagaa agatctgaaa cagattttct gaagaaagca gaagctctct      240

tcccattatg acttcggaaa tcacttatgc tgaagtgagg ttcaaaaatg aattcaagtc      300

ctcaggcatc aacacagcct cttctgcagc ttccaaggag aggactgccc ctcacaaaag      360

taataccgga ttccccaagc tgctttgtgc ctcactgttg atatttttcc tgctattggc      420

aatctcattc tttattgctt ttgtcaagac agcctggagc tgttgcccaa agaattggaa      480

gtcatttagt tccaactgct actttatttc tactgaatca gcatcttggc aagacagtga      540

gaaggactgt gctagaatgg aggctcacct gctggtgata aacactcaag aagagcagga      600

tttcatcttc cagaatctgc aagaagaatc tgcttatttt gtggggctct cagatccaga      660

aggtcagcga cattggcaat gggttgatca gacaccatac aatgaaagtt ccacattctg      720

gcatccacgt gagcccagtg atcccaatga gcgctgcgtt gtgctaaatt ttcgtaaatc      780

acccaaaaga tggggctgga atgatgttaa ttgtcttggt cctcaaaggt cagtttgtga      840

gatgatgaag atccacttat gaactgaaca ttctccatga acaggtggtt ggattggtat      900

ctgtcattgt agggatagat aataagctct tcttattcat gtgtaaggga ggtccataga      960

atttaggtgg tctgtcaact attctactta tgagagaatt ggtctgtaca ttgactgatt     1020

cactttttca taaagtgagc atttattgag cattttttca tgtgccagag cctgtactgg     1080

aggcccccat tgtgcacaca tggagagaac atgagtctct cttaattttt atctggttgc     1140

taaagaatta tttaccaata aaattatatg atgtggtgtc tcaaa                     1185


<210>  8
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Ser Glu Ile Thr Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Thr Ala Ser Ser Ala Ala Ser Lys Glu Arg 
            20                  25                  30          


Thr Ala Pro His Lys Ser Asn Thr Gly Phe Pro Lys Leu Leu Cys Ala 
        35                  40                  45              


Ser Leu Leu Ile Phe Phe Leu Leu Leu Ala Ile Ser Phe Phe Ile Ala 
    50                  55                  60                  


Phe Val Lys Thr Ala Trp Ser Cys Cys Pro Lys Asn Trp Lys Ser Phe 
65                  70                  75                  80  


Ser Ser Asn Cys Tyr Phe Ile Ser Thr Glu Ser Ala Ser Trp Gln Asp 
                85                  90                  95      


Ser Glu Lys Asp Cys Ala Arg Met Glu Ala His Leu Leu Val Ile Asn 
            100                 105                 110         


Thr Gln Glu Glu Gln Asp Phe Ile Phe Gln Asn Leu Gln Glu Glu Ser 
        115                 120                 125             


Ala Tyr Phe Val Gly Leu Ser Asp Pro Glu Gly Gln Arg His Trp Gln 
    130                 135                 140                 


Trp Val Asp Gln Thr Pro Tyr Asn Glu Ser Ser Thr Phe Trp His Pro 
145                 150                 155                 160 


Arg Glu Pro Ser Asp Pro Asn Glu Arg Cys Val Val Leu Asn Phe Arg 
                165                 170                 175     


Lys Ser Pro Lys Arg Trp Gly Trp Asn Asp Val Asn Cys Leu Gly Pro 
            180                 185                 190         


Gln Arg Ser Val Cys Glu Met Met Lys Ile His Leu 
        195                 200                 


<210>  9
<211>  14340
<212>  DNA
<213>  Homo sapiens

<400>  9
cccactcgct ggctctctct ccagctgcct cctctccagg tctctcctgg ctgcgcgcgc       60

tcctctcccc gcttctcccc ctcccgcagc ctcgccgcct tggtgccttc ctgcccggct      120

cggccggcgc tcgtccccgg ccccggcccc gccagcccgg gtctccgcgc tcggagcagc      180

tcagccctgc agtggctcgg gacccgatgc tatgagaggg aagcgagccg ggcgcccaga      240

ccttcaggag gcgtcggatg cgcggcgggt cttgggaccg ggctctctct ccggctcgcc      300

ttgccctcgg gtgattattt ggctccgctc atagccctgc cttcctcgga ggagccatcg      360

gtgtcgcgtg cgtgtggagt atctgcagac atgactgcgt ggaggagatt ccagtcgctg      420

ctcctgcttc tcgggctgct ggtgctgtgc gcgaggctcc tcactgcagc gaagggtcag      480

aactgtggag gcttagtcca gggtcccaat ggcactattg agagcccagg gtttcctcac      540

gggtatccga actatgccaa ctgcacctgg atcatcatca cgggcgagcg caataggata      600

cagttgtcct tccatacctt tgctcttgaa gaagattttg atattttatc agtttacgat      660

ggacagcctc aacaagggaa tttaaaagtg agattatcgg gatttcagct gccctcctct      720

atagtgagta caggatctat cctcactctg tggttcacga cagacttcgc tgtgagtgcc      780

caaggtttca aagcattata tgaagtttta cctagccaca cttgtggaaa tcctggagaa      840

atcctgaaag gagttctgca tggaacgaga ttcaacatag gagacaaaat ccggtacagc      900

tgcctccctg gctacatctt ggaaggccac gccatcctga cctgcatcgt cagcccagga      960

aatggtgcat cgtgggactt cccagctccc ttttgcagag ctgagggagc ctgcggagga     1020

accttacgcg ggaccagcag ctccatctcc agcccgcact tcccttcaga gtacgagaac     1080

aacgcggact gcacctggac cattctggct gagcccgggg acaccattgc gctggtcttc     1140

actgactttc agctagaaga aggatatgat ttcttagaga tcagtggcac ggaagctcca     1200

tccatatggc taactggcat gaacctcccc tctccagtta tcagtagcaa gaattggcta     1260

cgactccatt tcacctctga cagcaaccac cgacgcaaag gatttaacgc tcagttccaa     1320

gtgaaaaagg cgattgagtt gaagtcaaga ggagtcaaga tgctgcccag caaggatgga     1380

agccataaaa actctgtctt gagccaagga ggtgttgcat tggtctctga catgtgtcca     1440

gatcctggga ttccagaaaa tggtagaaga gcaggttccg acttcagggt tggtgcaaat     1500

gtacagtttt catgtgagga caattacgtg ctccagggat ctaaaagcat cacctgtcag     1560

agagttacag agacgctcgc tgcttggagt gaccacaggc ccatctgccg agcgagaaca     1620

tgtggatcca atctgcgtgg gcccagcggc gtcattacct cccctaatta tccggttcag     1680

tatgaagata atgcacactg tgtgtgggtc atcaccacca ccgacccgga caaggtcatc     1740

aagcttgcct ttgaagagtt tgagctggag cgaggctatg acaccctgac ggttggtgat     1800

gctgggaagg tgggagacac cagatcggtc ttgtacgtgc tcacgggatc cagtgttcct     1860

gacctcattg tgagcatgag caaccagatg tggctacatc tgcagtcgga tgatagcatt     1920

ggctcacctg ggtttaaagc tgtttaccaa gaaattgaaa agggagggtg tggggatcct     1980

ggaatccccg cctatgggaa gcggacgggc agcagtttcc tccatggaga tacactcacc     2040

tttgaatgcc cggcggcctt tgagctggtg ggggagagag ttatcacctg tcagcagaac     2100

aatcagtggt ctggcaacaa gcccagctgt gtattttcat gtttcttcaa ctttacggca     2160

tcatctggga ttattctgtc accaaattat ccagaggaat atgggaacaa catgaactgt     2220

gtctggttga ttatctcgga gccaggaagt cgaattcacc taatctttaa tgattttgat     2280

gttgagcctc agtttgactt tctcgcggtc aaggatgatg gcatttctga cataactgtc     2340

ctgggtactt tttctggcaa tgaagtgcct tcccagctgg ccagcagtgg gcatatagtt     2400

cgcttggaat ttcagtctga ccattccact actggcagag ggttcaacat cacttacacc     2460

acatttggtc agaatgagtg ccatgatcct ggcattccta taaacggacg acgttttggt     2520

gacaggtttc tactcgggag ctcggtttct ttccactgtg atgatggctt tgtcaagacc     2580

cagggatccg agtccattac ctgcatactg caagacggga acgtggtctg gagctccacc     2640

gtgccccgct gtgaagctcc atgtggtgga catctgacag cgtccagcgg agtcattttg     2700

cctcctggat ggccaggata ttataaggat tctttacatt gtgaatggat aattgaagca     2760

aaaccaggcc actctatcaa aataactttt gacagatttc agacagaggt caattatgac     2820

accttggagg tcagagatgg gccagccagt tcgtccccac tgatcggcga gtaccacggc     2880

acccaggcac cccagttcct catcagcacc gggaacttca tgtacctgct gttcaccact     2940

gacaacagcc gctccagcat cggcttcctc atccactatg agagtgtgac gcttgagtcg     3000

gattcctgcc tggacccggg catccctgtg aacggccatc gccacggtgg agactttggc     3060

atcaggtcca cagtgacttt cagctgtgac ccggggtaca cactaagtga cgacgagccc     3120

ctcgtctgtg agaggaacca ccagtggaac cacgccttgc ccagctgcga cgctctatgt     3180

ggaggctaca tccaagggaa gagtggaaca gtcctttctc ctgggtttcc agatttttat     3240

ccaaactctc taaactgcac gtggaccatt gaagtgtctc atgggaaagg agttcaaatg     3300

atctttcaca cctttcatct tgagagttcc cacgactatt tactgatcac agaggatgga     3360

agtttttccg agcccgttgc caggctcacc gggtcggtgt tgcctcatac gatcaaggca     3420

ggcctgtttg gaaacttcac tgcccagctt cggtttatat cagacttctc aatttcgtac     3480

gagggcttca atatcacatt ttcagaatat gacctggagc catgtgatga tcctggagtc     3540

cctgccttca gccgaagaat tggttttcac tttggtgtgg gagactctct gacgttttcc     3600

tgcttcctgg gatatcgttt agaaggtgcc accaagctta cctgcctggg tgggggccgc     3660

cgtgtgtgga gtgcacctct gccaaggtgt gtggccgaat gtggagcaag tgtcaaagga     3720

aatgaaggaa cattactgtc tccaaatttt ccatccaatt atgataataa ccatgagtgt     3780

atctataaaa tagaaacaga agccggcaag ggcatccacc ttagaacacg aagcttccag     3840

ctgtttgaag gagatactct aaaggtatat gatggaaaag acagttcctc acgtccactg     3900

ggcacgttca ctaaaaatga acttctgggg ctgatcctaa acagcacatc caatcacctg     3960

tggctagagt tcaacaccaa tggatctgac accgaccaag gttttcaact cacctatacc     4020

agttttgatc tggtaaaatg tgaggatccg ggcatcccta actacggcta taggatccgt     4080

gatgaaggcc actttaccga cactgtagtt ctgtacagtt gcaacccggg gtacgccatg     4140

catggcagca acaccctgac ctgtttgagt ggagacagga gagtgtggga caaaccacta     4200

ccttcgtgca tagcggaatg tggtggtcag atccatgcag ccacatcagg acgaatattg     4260

tcccctggct atccagctcc gtatgacaac aacctccact gcacctggat tatagaggca     4320

gacccaggaa agaccattag cctccatttc attgttttcg acacggagat ggctcacgac     4380

atcctcaagg tctgggacgg gccggtggac agtgacatcc tgctgaagga gtggagtggc     4440

tccgcccttc cggaggacat ccacagcacc ttcaactcac tcaccctgca gttcgacagc     4500

gacttcttca tcagcaagtc tggcttctcc atccagttct ccacctcaat tgcagccacc     4560

tgtaacgatc caggtatgcc ccaaaatggc acccgctatg gagacagcag agaggctgga     4620

gacaccgtca cattccagtg tgaccctggc tatcagctcc aaggacaagc caaaatcacc     4680

tgtgtgcagc tgaataaccg gttcttttgg caaccagacc ctcctacatg catagctgct     4740

tgtggaggga atctgacggg cccagcaggt gttattttgt cacccaacta cccacagccg     4800

tatcctcctg ggaaggaatg tgactggaga gtaaaagtga acccggactt tgtcatcgcc     4860

ttgatattca aaagtttcaa catggagccc agctatgact tcctacacat ctatgaaggg     4920

gaagattcca acagccccct cattgggagt taccagggct ctcaggcccc agaaagaata     4980

gagagtagcg gaaacagcct gtttctggca tttcggagtg atgcctccgt gggcctttca     5040

gggttcgcca ttgaatttaa agagaaacca cgggaagctt gttttgaccc aggaaatata     5100

atgaatggga caagagttgg aacagacttc aagcttggct ccaccatcac ctaccagtgt     5160

gactctggct ataagattct tgacccctca tccatcacct gtgtgattgg ggctgatggg     5220

aaaccctcct gggaccaagt gctgccctcc tgcaatgctc cctgtggagg ccagtacacg     5280

ggatcagaag gggtagtttt atcaccaaac tacccccata attacacagc tggtcaaata     5340

tgcctctatt ccatcacggt accaaaggaa ttcgtggtct ttggacagtt tgcctatttc     5400

cagacagccc tgaatgattt ggcagaatta tttgatggaa cccatgcaca ggccagactt     5460

ctcagctcac tctcggggtc tcactcaggg gaaacattgc ccttggctac gtcaaatcaa     5520

attctgctcc gattcagtgc aaagagcggt gcctctgccc gcggcttcca cttcgtgtat     5580

caagctgttc ctcgtaccag tgacacccaa tgcagctctg tccccgagcc cagatacgga     5640

aggagaattg gttctgagtt ttctgccggc tccatcgtcc gattcgagtg caacccggga     5700

tacctgcttc agggttccac ggcgctccac tgccagtccg tgcccaacgc cttggcacag     5760

tggaacgaca cgatccccag ctgtgtggta ccctgcagtg gcaatttcac tcaacgaaga     5820

ggtacaatcc tgtcccccgg ctaccctgag ccatacggaa acaacttgaa ctgtatatgg     5880

aagatcatag ttacggaggg ctcgggaatt cagatccaag tgatcagttt tgccacggag     5940

cagaactggg actcccttga gatccacgat ggtggggatg tgaccgcacc cagactggga     6000

agcttctcag gcaccacagt accggcactg ctgaacagta cttccaacca actctacctg     6060

catttccagt ctgacattag tgtggcagct gctggtttcc acctggaata caaaactgta     6120

ggtcttgctg catgccaaga accagccctc cccagcaaca gcatcaaaat cggagatcgg     6180

tacatggtga acgacgtgct ctccttccag tgcgagcccg ggtacaccct gcagggccgt     6240

tcccacattt cctgtatgcc agggaccgtt cgccgttgga actatccgtc tcccctgtgc     6300

attgcaacct gtggagggac gctgagcacc ttgggtggtg tgatcctgag ccccggcttc     6360

ccaggttctt accccaacaa cttagactgc acctggagga tctcattacc catcggctat     6420

ggtgcacata ttcagtttct gaatttttct accgaagcta atcatgactt ccttgaaatt     6480

caaaatggac cttaccacac cagccccatg attggacaat ttagcggcac ggatctcccc     6540

gcggccctgc tgagcacaac gcatgaaacc ctcatccact tttatagtga ccattcgcaa     6600

aaccggcaag gatttaaact tgcttaccaa gcctatgaat tacagaactg tccagatcca     6660

cccccatttc agaatgggta catgatcaac tcggattaca gcgtggggca atcagtatct     6720

ttcgagtgtt atcctgggta cattctaata ggccatcctg tcctcacttg tcagcatggg     6780

atcaacagaa actggaacta cccttttcca agatgtgatg ccccttgtgg gtacaacgta     6840

acttctcaga acggcaccat ctactcccct ggctttcctg atgagtatcc gatcctgaag     6900

gactgcattt ggctcatcac ggtgcctcca gggcacggag tttacatcaa cttcaccctg     6960

ttacagacgg aagctgtcaa cgattacatt gctgtttggg acggtcccga tcagaactca     7020

ccccagctgg gagttttcag tggcaacaca gccctcgaaa cggcgtatag ctccaccaac     7080

caagtcctgc tcaagttcca cagcgacttt tcaaatggag gcttctttgt cctcaatttc     7140

cacgcatttc agctcaagaa atgtcaacct cccccagcgg ttccacaggc agaaatgctt     7200

actgaggatg atgatttcga aataggagat tttgtgaagt accagtgcca ccccgggtac     7260

accttggtgg ggaccgacat tctgacttgc aagctcagtt cccagttgca gtttgagggt     7320

tctctcccaa catgtgaagc acaatgccca gcaaatgaag tccggactgg atcatcggga     7380

gtcattctca gtccagggta tccgggtaat tattttaact cccagacttg ctcttggagt     7440

attaaagtgg aaccaaacta caacattacc atctttgtgg acacatttca aagtgaaaag     7500

cagtttgatg cactggaagt gtttgatggt tcttctgggc aaagtcctct gctagtagtc     7560

ttaagtggga atcatactga acaatcaaat tttacaagca ggagtaatca gttatatctc     7620

cgctggtcca ctgaccatgc caccagtaag aaaggattca agattcgcta tgcagcacct     7680

tactgcagtt tgacccaccc cctgaagaat gggggtattc taaacaggac tgcaggagcg     7740

gttggaagca aagtgcatta tttttgcaag cctggatacc gaatggtcgg ccacagcaat     7800

gcaacctgta gacgaaaccc acttggcatg taccagtggg actccctcac gccactctgc     7860

caggctgtgt cctgtggaat cccagaatcc ccaggaaacg gttcatttac cgggaacgag     7920

ttcactttgg acagtaaagt ggtctatgaa tgtcatgagg gcttcaagct tgaatccagc     7980

cagcaagcaa cagccgtgtg tcaagaagat gggttgtgga gtaacaaggg gaagccgccc     8040

acgtgtaagc cggtcgcttg ccccagcatt gaagctcagc tctcagaaca tgtcatctgg     8100

aggctggttt caggatcctt gaatgagtac ggtgctcaag tattgctgag ctgcagtcct     8160

ggttactact tagaaggctg gaggctcctg cggtgccagg ccaatgggac gtggaacata     8220

ggagatgaga ggccaagctg tcgagttatc tcgtgtggaa gcctttcctt tcccccaaat     8280

ggcaacaaga ttggaacgtt gacagtttat ggggccacag ctatatttac gtgcaacacc     8340

ggctacacgc ttgtggggtc tcatgtcaga gagtgcttgg caaatgggct ctggagcggc     8400

agcgaaactc gatgtctggc tggccactgc ggttccccag acccgattgt gaacggtcac     8460

attagtggag atggcttcag ttacagagac acggtggttt accagtgcaa tcctggtttc     8520

cggcttgtgg gaacttccgt gaggatatgc ctgcaagacc acaagtggtc tggacaaacg     8580

cctgtctgtg tccccatcac atgtggtcac cctggaaacc ctgcccacgg attcactaat     8640

ggcagtgagt tcaacctgaa tgatgtcgtg aatttcacct gcaacacggg ctatttgctg     8700

cagggcgtgt ctcgagccca gtgtcggagc aacggccagt ggagtagccc tctgcccacg     8760

tgtcgagtgg tgaactgttc tgatccaggc tttgtggaaa atgccattcg tcacgggcaa     8820

cagaacttcc ctgagagttt tgagtatgga atgagtatcc tgtaccattg caagaaggga     8880

ttttacttgc tgggatcttc agccttgacc tgtatggcaa atggcttatg ggaccgatcc     8940

ctgcccaagt gtttggctat atcgtgtgga cacccagggg tccctgccaa cgccgtcctc     9000

actggagagc tgtttaccta tggcgccgtc gtgcactact cctgcagagg gagcgagagc     9060

ctcataggca acgacacgag agtgtgccag gaagacagtc actggagcgg ggcactgccc     9120

cactgcacag gaaataatcc tggattctgt ggtgatccgg ggaccccagc acatgggtct     9180

cggcttggtg atgactttaa gacaaagagt cttctccgct tctcctgtga aatggggcac     9240

cagctgaggg gctcccctga acgcacgtgt ttgctcaatg ggtcatggtc aggactgcag     9300

ccggtgtgtg aggccgtgtc ctgtggcaac cctggcacac ccaccaacgg aatgattgtc     9360

agtagtgatg gcattctgtt ctccagctcg gtcatctatg cctgctggga aggctacaag     9420

acctcagggc tcatgacacg gcattgcaca gccaatggga cctggacagg cactgctccc     9480

gactgcacaa ttataagttg tggggatcca ggcacactag caaatggcat ccagtttggg     9540

accgacttca ccttcaacaa gactgtgagc tatcagtgta acccaggcta tgtcatggaa     9600

gcagtcacat ccgccactat tcgctgtacc aaagacggca ggtggaatcc gagcaaacct     9660

gtctgcaaag ccgtgctgtg tcctcagccg ccgccggtgc agaatggaac agtggaggga     9720

agtgatttcc gctggggctc cagcataagt tacagctgca tggacggtta ccagctctct     9780

cactccgcca tcctctcctg tgaaggtcgc ggggtgtgga aaggagagat cccccagtgt     9840

ctccctgtgt tctgcggaga ccctggcatc cccgcagaag ggcgacttag tgggaaaagt     9900

ttcacctata agtccgaagt cttcttccag tgcaaatctc catttatact cgtgggatcc     9960

tccagaagag tctgccaagc tgacggcacg tggagcggca tacaacccac ctgcattgat    10020

cctgctcata acacctgccc agaccctggt acgccacact ttggaataca gaatagctcc    10080

agaggctatg aggttggaag cacggttttt ttcaggtgca gaaaaggcta ccatattcaa    10140

ggttccacga ctcgcacctg ccttgccaat ttaacatgga gtgggataca gaccgaatgt    10200

atacctcatg cctgcagaca gccagaaacc ccggcacacg cggatgtgag agccatcgat    10260

cttcctactt tcggctacac cttagtgtac acctgccatc caggcttttt cctcgcaggg    10320

ggatctgagc acagaacatg taaagcagac atgaaatgga caggaaagtc gcctgtgtgt    10380

aaaagtaaag gagtgagaga agttaatgaa acagttacta aaactccagt tccttcagat    10440

gtctttttcg tcaattcact gtggaagggg tattatgaat atttagggaa aagacaaccc    10500

gccactctaa ctgttgactg gttcaatgca acaagcagta aggtgaatgc caccttcagc    10560

gaagcctcgc cagtggagct gaagttgaca ggcatttaca agaaggagga ggcccactta    10620

ctcctgaaag cttttcaaat taaaggccag gcagatattt ttgtaagcaa gttcgaaaat    10680

gacaactggg gactagatgg ttatgtgtca tctggacttg aaagaggagg atttactttt    10740

caaggtgaca ttcatggaaa agactttgga aaatttaagc tagaaaggca agatccttta    10800

aacccagatc aagactcttc cagtcattac cacggcacca gcagtggctc tgtggcggct    10860

gccattctgg ttcctttctt tgctctaatt ttatcagggt ttgcatttta cctctacaaa    10920

cacagaacga gaccaaaagt tcaatacaat ggctatgctg ggcatgaaaa cagcaatgga    10980

caagcatcgt ttgaaaaccc catgtatgat acaaacttaa aacccacaga agccaaggct    11040

gtgaggtttg acacaactct gaacacagtc tgtacagtgg tatagccctc agtgccccaa    11100

caggactgat tcatagccat acctctgatg gacaagcagt gattcctttg gtgccatata    11160

ccactctccc ttccactctg gctttactgc agcgatcttc aaccttgtct actggcataa    11220

gtgcagcggg gatctctact caaatgtgtc agggtcttct acggatcaaa ctacacatgc    11280

gttttcattc caaaagtggg ttctaaatgc ctggctgcat ctgtatgaaa tcaaggcaca    11340

ctccaggaag actgccacgt cgcgccaaca cgtcatactc aatgcctcag actttcatat    11400

ttctgtgttg ctgagatgcc tttcaatgca atcgtctggg ctcgtggata tgtccctcag    11460

gtgcggtgac agaatggtgg caccacgata tgtgttctct tgtgttgttt ttccttttta    11520

aacccccatg aacacgaata ctctgaaaaa aataaaaagc tttctggaag aagacacctt    11580

tctgatagag gctcacacct acaaatgctt cactctgtcc ttccgagacc tgacaagctt    11640

tgaggacctc acagctcccc tgtgtgttca tctctaggga tgtttgcaat ttcccagtca    11700

gctgttctgt cgcagaatgt ttaatgcaca attttttgca ctagtgtgtt atgaatgact    11760

aagattctga taaaaaaaat aaattattta cacagggttt atacacacta tccattgtat    11820

ataagcatta tttcatatta tcaagctaaa cattccccca tcagcttagt tggagtgtta    11880

gggaaaagta ttcctagata tggcacagat tttaaaagga aatacagtat tgaagagatt    11940

tattttatta ttgcttcaat tagctccatt tacgtgttga attcattgaa gaggtccaat    12000

gagaaaaaaa cagaagcctc cttatttcac acgttttcct cctttagtac catcctcatc    12060

caattactgt ctctctgata ctacttaata gcagggggtt tgcagaaatt tctgtttgcc    12120

atgtaaaact gtgaatagta atttatttta gatagtcgat gaacttgtgg gttttagctc    12180

acaatgcagc cttccctttt gcagtgtttt ttttttgttt tttttttttt ttgtctttta    12240

ctgtgccatc gatctttgat attgcattga aagacaatat accacagtag caccttgaac    12300

tcagtgaaaa ttgttcagga tcaaaatacc aagtgttctt ttagagggaa ggaaaaagta    12360

cacacactct cctctcacaa tgatatattt tatacattca tttgttattt gtttcatgct    12420

ttatgattcc agatggaaag gtaatttcag tgacttttca agtttaaatt ccattatagg    12480

taaatgataa gttatgatgc aaataaaatc tataagatcc ccagggcaaa taaaaatcaa    12540

aacatgaagt agaagatgtg gccgtgaggt agtttatgta acaaattcaa agtgaaaatc    12600

atgtttactt ttacttatac ttatttgata aaaatatttt tgaaacgata gtacttattt    12660

tattatttga tatttcagtt cctattcaat tgtggcagat tttctctgtt tcacatttta    12720

gattggcgtt ggtaatagaa atgtcagaat gttcaaattg gccttcacgt tgtcggagtg    12780

aacacattga cacctagctt taagactgat ttatctgttg gtgtactgaa ggtttccatg    12840

taggacttca aatgtggaaa aggaaaagca gtcaggaaaa tggggcattc tttggagagt    12900

cacgcgtttt gattcggaca tttccgtaga gctcggctcc cagtgttgtg ttcctcggtc    12960

gaaagggtct ctgctgtttg gggactcact ggcctctcct agggactcct ttgtcttgtg    13020

aaccccacgc tgttggattc tgtatcatta tgctgaattc tctgcacagt tttccctggc    13080

caacctgccc acatccttgg agatttgctt tgccagtggg aatccttaca ttgctgtttc    13140

acagtagacg ggacgaggtc agcgggagtc gtgctcctaa cacacacatt gaacgaaaca    13200

gaagatgatt gaaagtgtga ggaggctcgt gtgcaaggga gaacagggtt actatacata    13260

ttagtgtata tatatacata catatatata tatatatatt gtacatatct aagtttgagt    13320

cattcaaact aggtgcaaaa tgctgacttc agagtctgaa ttaacatctc tgttcccata    13380

tccctgacct gctccctggt caacgatgct atgaaatcct gaaatgacag gacatacata    13440

catacaagaa accacatatc aaattagata tgattttcct ttgtgtgcaa agtcaaactg    13500

tcctagggtt gccagtttga agcatgttat ttaaatgaaa aaaaaaatca gtgaaattct    13560

cgtgtgagaa ttctgcctag tttcttccta aggttgtgtg cagtgttgaa cggcgtctcc    13620

gcaaggtgtt ggaggatctc attttagggc agtcaggagc tgtgcttgct gagttaggtc    13680

tagaagactc ttccctgaag gcaacgggaa cacgcgtgag ggacgcgacc acacactaac    13740

agaggacacg tgcttcagag ctgtttaaaa ctgctgcttg ttttacacac acatcttgcc    13800

ttttttcagg ctagctgcaa taattttttt cttctgtaaa atattttgta aacaacaaca    13860

aaaagctatt ataaaaaggg ggtaaaaaaa agaacgctgg cattatgatc aggaaaaccc    13920

attgtcatcg ccgaccctcc ctcccgtccc accacacgct gctgtcacga cgtaggtgcg    13980

aaagaccttt ttgtacagag atatattttt tatgaagaat ttgtaaaatt attaaatatg    14040

ctgtaatttt ttgattaatg taggtacatt gttaaaaaat aaatgttttt acaatacaga    14100

actgtaattt tcccaataat gtaaaatgta ccatctctag ctgattttca gttccaatcc    14160

tattacacat gtattaatat taaagtggcc tgttaaaatg aacagtatct tttttttgtc    14220

aaaaaaatta taaagagggt gtaatatagc ctgtgcaatg ccaccaatct ttaaagcaaa    14280

tcagagttct aattaaatat ttaattttag atttctaaaa aaaaaaaaaa aaaaaaaaaa    14340


<210>  10
<211>  3564
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys 
            20                  25                  30          


Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe 
        35                  40                  45              


Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr 
    50                  55                  60                  


Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu 
65                  70                  75                  80  


Glu Asp Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly 
                85                  90                  95      


Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val 
            100                 105                 110         


Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val 
        115                 120                 125             


Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr 
    130                 135                 140                 


Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg 
145                 150                 155                 160 


Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile 
                165                 170                 175     


Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly 
            180                 185                 190         


Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys 
        195                 200                 205             


Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe 
    210                 215                 220                 


Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala 
225                 230                 235                 240 


Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu 
                245                 250                 255     


Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile 
            260                 265                 270         


Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn 
        275                 280                 285             


Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly 
    290                 295                 300                 


Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg 
305                 310                 315                 320 


Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val 
                325                 330                 335     


Leu Ser Gln Gly Gly Val Ala Leu Val Ser Asp Met Cys Pro Asp Pro 
            340                 345                 350         


Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Arg Val Gly 
        355                 360                 365             


Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly Ser 
    370                 375                 380                 


Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp Ser 
385                 390                 395                 400 


Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu Arg 
                405                 410                 415     


Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr Glu 
            420                 425                 430         


Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp Lys 
        435                 440                 445             


Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr Asp 
    450                 455                 460                 


Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser Val 
465                 470                 475                 480 


Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser Met 
                485                 490                 495     


Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly Ser 
            500                 505                 510         


Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys Gly 
        515                 520                 525             


Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe Leu 
    530                 535                 540                 


His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu Val 
545                 550                 555                 560 


Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly Asn 
                565                 570                 575     


Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser Ser 
            580                 585                 590         


Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn Met 
        595                 600                 605             


Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His Leu 
    610                 615                 620                 


Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala Val 
625                 630                 635                 640 


Lys Asp Asp Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser Gly 
                645                 650                 655     


Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg Leu 
            660                 665                 670         


Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile Thr 
        675                 680                 685             


Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro Ile 
    690                 695                 700                 


Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val Ser 
705                 710                 715                 720 


Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser Ile 
                725                 730                 735     


Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val Pro 
            740                 745                 750         


Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly Val 
        755                 760                 765             


Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His Cys 
    770                 775                 780                 


Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Ile Thr Phe 
785                 790                 795                 800 


Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg Asp 
                805                 810                 815     


Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr Gln 
            820                 825                 830         


Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu Phe 
        835                 840                 845             


Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr Glu 
    850                 855                 860                 


Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro Val 
865                 870                 875                 880 


Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val Thr 
                885                 890                 895     


Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu Val 
            900                 905                 910         


Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp Ala 
        915                 920                 925             


Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser Pro 
    930                 935                 940                 


Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Ile 
945                 950                 955                 960 


Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe His 
                965                 970                 975     


Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser Phe 
            980                 985                 990         


Ser Glu Pro Val Ala Arg Leu Thr  Gly Ser Val Leu Pro  His Thr Ile 
        995                 1000                 1005             


Lys Ala  Gly Leu Phe Gly Asn  Phe Thr Ala Gln Leu  Arg Phe Ile 
    1010                 1015                 1020             


Ser Asp  Phe Ser Ile Ser Tyr  Glu Gly Phe Asn Ile  Thr Phe Ser 
    1025                 1030                 1035             


Glu Tyr  Asp Leu Glu Pro Cys  Asp Asp Pro Gly Val  Pro Ala Phe 
    1040                 1045                 1050             


Ser Arg  Arg Ile Gly Phe His  Phe Gly Val Gly Asp  Ser Leu Thr 
    1055                 1060                 1065             


Phe Ser  Cys Phe Leu Gly Tyr  Arg Leu Glu Gly Ala  Thr Lys Leu 
    1070                 1075                 1080             


Thr Cys  Leu Gly Gly Gly Arg  Arg Val Trp Ser Ala  Pro Leu Pro 
    1085                 1090                 1095             


Arg Cys  Val Ala Glu Cys Gly  Ala Ser Val Lys Gly  Asn Glu Gly 
    1100                 1105                 1110             


Thr Leu  Leu Ser Pro Asn Phe  Pro Ser Asn Tyr Asp  Asn Asn His 
    1115                 1120                 1125             


Glu Cys  Ile Tyr Lys Ile Glu  Thr Glu Ala Gly Lys  Gly Ile His 
    1130                 1135                 1140             


Leu Arg  Thr Arg Ser Phe Gln  Leu Phe Glu Gly Asp  Thr Leu Lys 
    1145                 1150                 1155             


Val Tyr  Asp Gly Lys Asp Ser  Ser Ser Arg Pro Leu  Gly Thr Phe 
    1160                 1165                 1170             


Thr Lys  Asn Glu Leu Leu Gly  Leu Ile Leu Asn Ser  Thr Ser Asn 
    1175                 1180                 1185             


His Leu  Trp Leu Glu Phe Asn  Thr Asn Gly Ser Asp  Thr Asp Gln 
    1190                 1195                 1200             


Gly Phe  Gln Leu Thr Tyr Thr  Ser Phe Asp Leu Val  Lys Cys Glu 
    1205                 1210                 1215             


Asp Pro  Gly Ile Pro Asn Tyr  Gly Tyr Arg Ile Arg  Asp Glu Gly 
    1220                 1225                 1230             


His Phe  Thr Asp Thr Val Val  Leu Tyr Ser Cys Asn  Pro Gly Tyr 
    1235                 1240                 1245             


Ala Met  His Gly Ser Asn Thr  Leu Thr Cys Leu Ser  Gly Asp Arg 
    1250                 1255                 1260             


Arg Val  Trp Asp Lys Pro Leu  Pro Ser Cys Ile Ala  Glu Cys Gly 
    1265                 1270                 1275             


Gly Gln  Ile His Ala Ala Thr  Ser Gly Arg Ile Leu  Ser Pro Gly 
    1280                 1285                 1290             


Tyr Pro  Ala Pro Tyr Asp Asn  Asn Leu His Cys Thr  Trp Ile Ile 
    1295                 1300                 1305             


Glu Ala  Asp Pro Gly Lys Thr  Ile Ser Leu His Phe  Ile Val Phe 
    1310                 1315                 1320             


Asp Thr  Glu Met Ala His Asp  Ile Leu Lys Val Trp  Asp Gly Pro 
    1325                 1330                 1335             


Val Asp  Ser Asp Ile Leu Leu  Lys Glu Trp Ser Gly  Ser Ala Leu 
    1340                 1345                 1350             


Pro Glu  Asp Ile His Ser Thr  Phe Asn Ser Leu Thr  Leu Gln Phe 
    1355                 1360                 1365             


Asp Ser  Asp Phe Phe Ile Ser  Lys Ser Gly Phe Ser  Ile Gln Phe 
    1370                 1375                 1380             


Ser Thr  Ser Ile Ala Ala Thr  Cys Asn Asp Pro Gly  Met Pro Gln 
    1385                 1390                 1395             


Asn Gly  Thr Arg Tyr Gly Asp  Ser Arg Glu Ala Gly  Asp Thr Val 
    1400                 1405                 1410             


Thr Phe  Gln Cys Asp Pro Gly  Tyr Gln Leu Gln Gly  Gln Ala Lys 
    1415                 1420                 1425             


Ile Thr  Cys Val Gln Leu Asn  Asn Arg Phe Phe Trp  Gln Pro Asp 
    1430                 1435                 1440             


Pro Pro  Thr Cys Ile Ala Ala  Cys Gly Gly Asn Leu  Thr Gly Pro 
    1445                 1450                 1455             


Ala Gly  Val Ile Leu Ser Pro  Asn Tyr Pro Gln Pro  Tyr Pro Pro 
    1460                 1465                 1470             


Gly Lys  Glu Cys Asp Trp Arg  Val Lys Val Asn Pro  Asp Phe Val 
    1475                 1480                 1485             


Ile Ala  Leu Ile Phe Lys Ser  Phe Asn Met Glu Pro  Ser Tyr Asp 
    1490                 1495                 1500             


Phe Leu  His Ile Tyr Glu Gly  Glu Asp Ser Asn Ser  Pro Leu Ile 
    1505                 1510                 1515             


Gly Ser  Tyr Gln Gly Ser Gln  Ala Pro Glu Arg Ile  Glu Ser Ser 
    1520                 1525                 1530             


Gly Asn  Ser Leu Phe Leu Ala  Phe Arg Ser Asp Ala  Ser Val Gly 
    1535                 1540                 1545             


Leu Ser  Gly Phe Ala Ile Glu  Phe Lys Glu Lys Pro  Arg Glu Ala 
    1550                 1555                 1560             


Cys Phe  Asp Pro Gly Asn Ile  Met Asn Gly Thr Arg  Val Gly Thr 
    1565                 1570                 1575             


Asp Phe  Lys Leu Gly Ser Thr  Ile Thr Tyr Gln Cys  Asp Ser Gly 
    1580                 1585                 1590             


Tyr Lys  Ile Leu Asp Pro Ser  Ser Ile Thr Cys Val  Ile Gly Ala 
    1595                 1600                 1605             


Asp Gly  Lys Pro Ser Trp Asp  Gln Val Leu Pro Ser  Cys Asn Ala 
    1610                 1615                 1620             


Pro Cys  Gly Gly Gln Tyr Thr  Gly Ser Glu Gly Val  Val Leu Ser 
    1625                 1630                 1635             


Pro Asn  Tyr Pro His Asn Tyr  Thr Ala Gly Gln Ile  Cys Leu Tyr 
    1640                 1645                 1650             


Ser Ile  Thr Val Pro Lys Glu  Phe Val Val Phe Gly  Gln Phe Ala 
    1655                 1660                 1665             


Tyr Phe  Gln Thr Ala Leu Asn  Asp Leu Ala Glu Leu  Phe Asp Gly 
    1670                 1675                 1680             


Thr His  Ala Gln Ala Arg Leu  Leu Ser Ser Leu Ser  Gly Ser His 
    1685                 1690                 1695             


Ser Gly  Glu Thr Leu Pro Leu  Ala Thr Ser Asn Gln  Ile Leu Leu 
    1700                 1705                 1710             


Arg Phe  Ser Ala Lys Ser Gly  Ala Ser Ala Arg Gly  Phe His Phe 
    1715                 1720                 1725             


Val Tyr  Gln Ala Val Pro Arg  Thr Ser Asp Thr Gln  Cys Ser Ser 
    1730                 1735                 1740             


Val Pro  Glu Pro Arg Tyr Gly  Arg Arg Ile Gly Ser  Glu Phe Ser 
    1745                 1750                 1755             


Ala Gly  Ser Ile Val Arg Phe  Glu Cys Asn Pro Gly  Tyr Leu Leu 
    1760                 1765                 1770             


Gln Gly  Ser Thr Ala Leu His  Cys Gln Ser Val Pro  Asn Ala Leu 
    1775                 1780                 1785             


Ala Gln  Trp Asn Asp Thr Ile  Pro Ser Cys Val Val  Pro Cys Ser 
    1790                 1795                 1800             


Gly Asn  Phe Thr Gln Arg Arg  Gly Thr Ile Leu Ser  Pro Gly Tyr 
    1805                 1810                 1815             


Pro Glu  Pro Tyr Gly Asn Asn  Leu Asn Cys Ile Trp  Lys Ile Ile 
    1820                 1825                 1830             


Val Thr  Glu Gly Ser Gly Ile  Gln Ile Gln Val Ile  Ser Phe Ala 
    1835                 1840                 1845             


Thr Glu  Gln Asn Trp Asp Ser  Leu Glu Ile His Asp  Gly Gly Asp 
    1850                 1855                 1860             


Val Thr  Ala Pro Arg Leu Gly  Ser Phe Ser Gly Thr  Thr Val Pro 
    1865                 1870                 1875             


Ala Leu  Leu Asn Ser Thr Ser  Asn Gln Leu Tyr Leu  His Phe Gln 
    1880                 1885                 1890             


Ser Asp  Ile Ser Val Ala Ala  Ala Gly Phe His Leu  Glu Tyr Lys 
    1895                 1900                 1905             


Thr Val  Gly Leu Ala Ala Cys  Gln Glu Pro Ala Leu  Pro Ser Asn 
    1910                 1915                 1920             


Ser Ile  Lys Ile Gly Asp Arg  Tyr Met Val Asn Asp  Val Leu Ser 
    1925                 1930                 1935             


Phe Gln  Cys Glu Pro Gly Tyr  Thr Leu Gln Gly Arg  Ser His Ile 
    1940                 1945                 1950             


Ser Cys  Met Pro Gly Thr Val  Arg Arg Trp Asn Tyr  Pro Ser Pro 
    1955                 1960                 1965             


Leu Cys  Ile Ala Thr Cys Gly  Gly Thr Leu Ser Thr  Leu Gly Gly 
    1970                 1975                 1980             


Val Ile  Leu Ser Pro Gly Phe  Pro Gly Ser Tyr Pro  Asn Asn Leu 
    1985                 1990                 1995             


Asp Cys  Thr Trp Arg Ile Ser  Leu Pro Ile Gly Tyr  Gly Ala His 
    2000                 2005                 2010             


Ile Gln  Phe Leu Asn Phe Ser  Thr Glu Ala Asn His  Asp Phe Leu 
    2015                 2020                 2025             


Glu Ile  Gln Asn Gly Pro Tyr  His Thr Ser Pro Met  Ile Gly Gln 
    2030                 2035                 2040             


Phe Ser  Gly Thr Asp Leu Pro  Ala Ala Leu Leu Ser  Thr Thr His 
    2045                 2050                 2055             


Glu Thr  Leu Ile His Phe Tyr  Ser Asp His Ser Gln  Asn Arg Gln 
    2060                 2065                 2070             


Gly Phe  Lys Leu Ala Tyr Gln  Ala Tyr Glu Leu Gln  Asn Cys Pro 
    2075                 2080                 2085             


Asp Pro  Pro Pro Phe Gln Asn  Gly Tyr Met Ile Asn  Ser Asp Tyr 
    2090                 2095                 2100             


Ser Val  Gly Gln Ser Val Ser  Phe Glu Cys Tyr Pro  Gly Tyr Ile 
    2105                 2110                 2115             


Leu Ile  Gly His Pro Val Leu  Thr Cys Gln His Gly  Ile Asn Arg 
    2120                 2125                 2130             


Asn Trp  Asn Tyr Pro Phe Pro  Arg Cys Asp Ala Pro  Cys Gly Tyr 
    2135                 2140                 2145             


Asn Val  Thr Ser Gln Asn Gly  Thr Ile Tyr Ser Pro  Gly Phe Pro 
    2150                 2155                 2160             


Asp Glu  Tyr Pro Ile Leu Lys  Asp Cys Ile Trp Leu  Ile Thr Val 
    2165                 2170                 2175             


Pro Pro  Gly His Gly Val Tyr  Ile Asn Phe Thr Leu  Leu Gln Thr 
    2180                 2185                 2190             


Glu Ala  Val Asn Asp Tyr Ile  Ala Val Trp Asp Gly  Pro Asp Gln 
    2195                 2200                 2205             


Asn Ser  Pro Gln Leu Gly Val  Phe Ser Gly Asn Thr  Ala Leu Glu 
    2210                 2215                 2220             


Thr Ala  Tyr Ser Ser Thr Asn  Gln Val Leu Leu Lys  Phe His Ser 
    2225                 2230                 2235             


Asp Phe  Ser Asn Gly Gly Phe  Phe Val Leu Asn Phe  His Ala Phe 
    2240                 2245                 2250             


Gln Leu  Lys Lys Cys Gln Pro  Pro Pro Ala Val Pro  Gln Ala Glu 
    2255                 2260                 2265             


Met Leu  Thr Glu Asp Asp Asp  Phe Glu Ile Gly Asp  Phe Val Lys 
    2270                 2275                 2280             


Tyr Gln  Cys His Pro Gly Tyr  Thr Leu Val Gly Thr  Asp Ile Leu 
    2285                 2290                 2295             


Thr Cys  Lys Leu Ser Ser Gln  Leu Gln Phe Glu Gly  Ser Leu Pro 
    2300                 2305                 2310             


Thr Cys  Glu Ala Gln Cys Pro  Ala Asn Glu Val Arg  Thr Gly Ser 
    2315                 2320                 2325             


Ser Gly  Val Ile Leu Ser Pro  Gly Tyr Pro Gly Asn  Tyr Phe Asn 
    2330                 2335                 2340             


Ser Gln  Thr Cys Ser Trp Ser  Ile Lys Val Glu Pro  Asn Tyr Asn 
    2345                 2350                 2355             


Ile Thr  Ile Phe Val Asp Thr  Phe Gln Ser Glu Lys  Gln Phe Asp 
    2360                 2365                 2370             


Ala Leu  Glu Val Phe Asp Gly  Ser Ser Gly Gln Ser  Pro Leu Leu 
    2375                 2380                 2385             


Val Val  Leu Ser Gly Asn His  Thr Glu Gln Ser Asn  Phe Thr Ser 
    2390                 2395                 2400             


Arg Ser  Asn Gln Leu Tyr Leu  Arg Trp Ser Thr Asp  His Ala Thr 
    2405                 2410                 2415             


Ser Lys  Lys Gly Phe Lys Ile  Arg Tyr Ala Ala Pro  Tyr Cys Ser 
    2420                 2425                 2430             


Leu Thr  His Pro Leu Lys Asn  Gly Gly Ile Leu Asn  Arg Thr Ala 
    2435                 2440                 2445             


Gly Ala  Val Gly Ser Lys Val  His Tyr Phe Cys Lys  Pro Gly Tyr 
    2450                 2455                 2460             


Arg Met  Val Gly His Ser Asn  Ala Thr Cys Arg Arg  Asn Pro Leu 
    2465                 2470                 2475             


Gly Met  Tyr Gln Trp Asp Ser  Leu Thr Pro Leu Cys  Gln Ala Val 
    2480                 2485                 2490             


Ser Cys  Gly Ile Pro Glu Ser  Pro Gly Asn Gly Ser  Phe Thr Gly 
    2495                 2500                 2505             


Asn Glu  Phe Thr Leu Asp Ser  Lys Val Val Tyr Glu  Cys His Glu 
    2510                 2515                 2520             


Gly Phe  Lys Leu Glu Ser Ser  Gln Gln Ala Thr Ala  Val Cys Gln 
    2525                 2530                 2535             


Glu Asp  Gly Leu Trp Ser Asn  Lys Gly Lys Pro Pro  Thr Cys Lys 
    2540                 2545                 2550             


Pro Val  Ala Cys Pro Ser Ile  Glu Ala Gln Leu Ser  Glu His Val 
    2555                 2560                 2565             


Ile Trp  Arg Leu Val Ser Gly  Ser Leu Asn Glu Tyr  Gly Ala Gln 
    2570                 2575                 2580             


Val Leu  Leu Ser Cys Ser Pro  Gly Tyr Tyr Leu Glu  Gly Trp Arg 
    2585                 2590                 2595             


Leu Leu  Arg Cys Gln Ala Asn  Gly Thr Trp Asn Ile  Gly Asp Glu 
    2600                 2605                 2610             


Arg Pro  Ser Cys Arg Val Ile  Ser Cys Gly Ser Leu  Ser Phe Pro 
    2615                 2620                 2625             


Pro Asn  Gly Asn Lys Ile Gly  Thr Leu Thr Val Tyr  Gly Ala Thr 
    2630                 2635                 2640             


Ala Ile  Phe Thr Cys Asn Thr  Gly Tyr Thr Leu Val  Gly Ser His 
    2645                 2650                 2655             


Val Arg  Glu Cys Leu Ala Asn  Gly Leu Trp Ser Gly  Ser Glu Thr 
    2660                 2665                 2670             


Arg Cys  Leu Ala Gly His Cys  Gly Ser Pro Asp Pro  Ile Val Asn 
    2675                 2680                 2685             


Gly His  Ile Ser Gly Asp Gly  Phe Ser Tyr Arg Asp  Thr Val Val 
    2690                 2695                 2700             


Tyr Gln  Cys Asn Pro Gly Phe  Arg Leu Val Gly Thr  Ser Val Arg 
    2705                 2710                 2715             


Ile Cys  Leu Gln Asp His Lys  Trp Ser Gly Gln Thr  Pro Val Cys 
    2720                 2725                 2730             


Val Pro  Ile Thr Cys Gly His  Pro Gly Asn Pro Ala  His Gly Phe 
    2735                 2740                 2745             


Thr Asn  Gly Ser Glu Phe Asn  Leu Asn Asp Val Val  Asn Phe Thr 
    2750                 2755                 2760             


Cys Asn  Thr Gly Tyr Leu Leu  Gln Gly Val Ser Arg  Ala Gln Cys 
    2765                 2770                 2775             


Arg Ser  Asn Gly Gln Trp Ser  Ser Pro Leu Pro Thr  Cys Arg Val 
    2780                 2785                 2790             


Val Asn  Cys Ser Asp Pro Gly  Phe Val Glu Asn Ala  Ile Arg His 
    2795                 2800                 2805             


Gly Gln  Gln Asn Phe Pro Glu  Ser Phe Glu Tyr Gly  Met Ser Ile 
    2810                 2815                 2820             


Leu Tyr  His Cys Lys Lys Gly  Phe Tyr Leu Leu Gly  Ser Ser Ala 
    2825                 2830                 2835             


Leu Thr  Cys Met Ala Asn Gly  Leu Trp Asp Arg Ser  Leu Pro Lys 
    2840                 2845                 2850             


Cys Leu  Ala Ile Ser Cys Gly  His Pro Gly Val Pro  Ala Asn Ala 
    2855                 2860                 2865             


Val Leu  Thr Gly Glu Leu Phe  Thr Tyr Gly Ala Val  Val His Tyr 
    2870                 2875                 2880             


Ser Cys  Arg Gly Ser Glu Ser  Leu Ile Gly Asn Asp  Thr Arg Val 
    2885                 2890                 2895             


Cys Gln  Glu Asp Ser His Trp  Ser Gly Ala Leu Pro  His Cys Thr 
    2900                 2905                 2910             


Gly Asn  Asn Pro Gly Phe Cys  Gly Asp Pro Gly Thr  Pro Ala His 
    2915                 2920                 2925             


Gly Ser  Arg Leu Gly Asp Asp  Phe Lys Thr Lys Ser  Leu Leu Arg 
    2930                 2935                 2940             


Phe Ser  Cys Glu Met Gly His  Gln Leu Arg Gly Ser  Pro Glu Arg 
    2945                 2950                 2955             


Thr Cys  Leu Leu Asn Gly Ser  Trp Ser Gly Leu Gln  Pro Val Cys 
    2960                 2965                 2970             


Glu Ala  Val Ser Cys Gly Asn  Pro Gly Thr Pro Thr  Asn Gly Met 
    2975                 2980                 2985             


Ile Val  Ser Ser Asp Gly Ile  Leu Phe Ser Ser Ser  Val Ile Tyr 
    2990                 2995                 3000             


Ala Cys  Trp Glu Gly Tyr Lys  Thr Ser Gly Leu Met  Thr Arg His 
    3005                 3010                 3015             


Cys Thr  Ala Asn Gly Thr Trp  Thr Gly Thr Ala Pro  Asp Cys Thr 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Asp Pro  Gly Thr Leu Ala Asn  Gly Ile Gln 
    3035                 3040                 3045             


Phe Gly  Thr Asp Phe Thr Phe  Asn Lys Thr Val Ser  Tyr Gln Cys 
    3050                 3055                 3060             


Asn Pro  Gly Tyr Val Met Glu  Ala Val Thr Ser Ala  Thr Ile Arg 
    3065                 3070                 3075             


Cys Thr  Lys Asp Gly Arg Trp  Asn Pro Ser Lys Pro  Val Cys Lys 
    3080                 3085                 3090             


Ala Val  Leu Cys Pro Gln Pro  Pro Pro Val Gln Asn  Gly Thr Val 
    3095                 3100                 3105             


Glu Gly  Ser Asp Phe Arg Trp  Gly Ser Ser Ile Ser  Tyr Ser Cys 
    3110                 3115                 3120             


Met Asp  Gly Tyr Gln Leu Ser  His Ser Ala Ile Leu  Ser Cys Glu 
    3125                 3130                 3135             


Gly Arg  Gly Val Trp Lys Gly  Glu Ile Pro Gln Cys  Leu Pro Val 
    3140                 3145                 3150             


Phe Cys  Gly Asp Pro Gly Ile  Pro Ala Glu Gly Arg  Leu Ser Gly 
    3155                 3160                 3165             


Lys Ser  Phe Thr Tyr Lys Ser  Glu Val Phe Phe Gln  Cys Lys Ser 
    3170                 3175                 3180             


Pro Phe  Ile Leu Val Gly Ser  Ser Arg Arg Val Cys  Gln Ala Asp 
    3185                 3190                 3195             


Gly Thr  Trp Ser Gly Ile Gln  Pro Thr Cys Ile Asp  Pro Ala His 
    3200                 3205                 3210             


Asn Thr  Cys Pro Asp Pro Gly  Thr Pro His Phe Gly  Ile Gln Asn 
    3215                 3220                 3225             


Ser Ser  Arg Gly Tyr Glu Val  Gly Ser Thr Val Phe  Phe Arg Cys 
    3230                 3235                 3240             


Arg Lys  Gly Tyr His Ile Gln  Gly Ser Thr Thr Arg  Thr Cys Leu 
    3245                 3250                 3255             


Ala Asn  Leu Thr Trp Ser Gly  Ile Gln Thr Glu Cys  Ile Pro His 
    3260                 3265                 3270             


Ala Cys  Arg Gln Pro Glu Thr  Pro Ala His Ala Asp  Val Arg Ala 
    3275                 3280                 3285             


Ile Asp  Leu Pro Thr Phe Gly  Tyr Thr Leu Val Tyr  Thr Cys His 
    3290                 3295                 3300             


Pro Gly  Phe Phe Leu Ala Gly  Gly Ser Glu His Arg  Thr Cys Lys 
    3305                 3310                 3315             


Ala Asp  Met Lys Trp Thr Gly  Lys Ser Pro Val Cys  Lys Ser Lys 
    3320                 3325                 3330             


Gly Val  Arg Glu Val Asn Glu  Thr Val Thr Lys Thr  Pro Val Pro 
    3335                 3340                 3345             


Ser Asp  Val Phe Phe Val Asn  Ser Leu Trp Lys Gly  Tyr Tyr Glu 
    3350                 3355                 3360             


Tyr Leu  Gly Lys Arg Gln Pro  Ala Thr Leu Thr Val  Asp Trp Phe 
    3365                 3370                 3375             


Asn Ala  Thr Ser Ser Lys Val  Asn Ala Thr Phe Ser  Glu Ala Ser 
    3380                 3385                 3390             


Pro Val  Glu Leu Lys Leu Thr  Gly Ile Tyr Lys Lys  Glu Glu Ala 
    3395                 3400                 3405             


His Leu  Leu Leu Lys Ala Phe  Gln Ile Lys Gly Gln  Ala Asp Ile 
    3410                 3415                 3420             


Phe Val  Ser Lys Phe Glu Asn  Asp Asn Trp Gly Leu  Asp Gly Tyr 
    3425                 3430                 3435             


Val Ser  Ser Gly Leu Glu Arg  Gly Gly Phe Thr Phe  Gln Gly Asp 
    3440                 3445                 3450             


Ile His  Gly Lys Asp Phe Gly  Lys Phe Lys Leu Glu  Arg Gln Asp 
    3455                 3460                 3465             


Pro Leu  Asn Pro Asp Gln Asp  Ser Ser Ser His Tyr  His Gly Thr 
    3470                 3475                 3480             


Ser Ser  Gly Ser Val Ala Ala  Ala Ile Leu Val Pro  Phe Phe Ala 
    3485                 3490                 3495             


Leu Ile  Leu Ser Gly Phe Ala  Phe Tyr Leu Tyr Lys  His Arg Thr 
    3500                 3505                 3510             


Arg Pro  Lys Val Gln Tyr Asn  Gly Tyr Ala Gly His  Glu Asn Ser 
    3515                 3520                 3525             


Asn Gly  Gln Ala Ser Phe Glu  Asn Pro Met Tyr Asp  Thr Asn Leu 
    3530                 3535                 3540             


Lys Pro  Thr Glu Ala Lys Ala  Val Arg Phe Asp Thr  Thr Leu Asn 
    3545                 3550                 3555             


Thr Val  Cys Thr Val Val 
    3560                 


<210>  11
<211>  12351
<212>  DNA
<213>  Homo sapiens

<400>  11
atgggagcta cagggcgcct cgagctcaca ctggccgccc ctccccatcc gggcccagcc       60

tttcagcgtt caaaagccag ggagacccaa ggagaggagg aagggagtga aatgcagatc      120

gccaaaagtg actccataca tcacatgagc cactcccagg ggcagccaga gctgcctcct      180

ctgcctgctt ctgctaatga ggaaccgtct ggactctatc agactgtcat gtcacacagc      240

ttttacccgc ccttgatgca acgcacgtca tggaccttgg ctgcaccctt caaagaacag      300

catcaccacc gtggacccag tgattccatc gccaacaact actccttgat ggcccaggac      360

ctgaagctga aagatctgct gaaggtctac caaccggcca ccatcagtgt ccctagggac      420

aggaccggtc aggggctgcc atcatcagga aatagaagct catcagagcc catgaggaaa      480

aaaacgaagt tttcctccag aaacaaagag gattccacta ggatcaagtt ggccttcaag      540

acgtcaatct tctcacccat gaagaaggag gtaaagacat ctttgacgtt cccaggaagc      600

agaccaatga gtccagaaca gcagctcgat gtcatgttac agcaggagat ggaaatggaa      660

agtaaagaaa agaagccatc tgaatcggac ctggagagat actattacta tctgaccaat      720

ggaattcgca aagacatgat tgcccctgag gagggtgaag tgatggttcg gatttcaaag      780

ctgatttcta acacgctgct gacgagtccc ttcctggagc ccctgatggt ggtcctcgtg      840

caggagaagg agaatgacta ttactgtagc ctcatgaaaa gcatcgttga ttacatcctc      900

atggacccaa tggagagaaa acggctcttt attgagagca tcccccgctt gtttcctcaa      960

agagtgatcc gggcccctgt gccctggcac agtgtctaca ggagcgccaa gaagtggaac     1020

gaggagcatc tgcacacggt gaaccccatg atgctcaggc tgaaagaact gtggtttgca     1080

gaattcagag acctcaggtt tgttcgaaca gcagaaatac tagcgggaaa attgcctctg     1140

cagcctcagg aattttggga tgtgatccag aaacactgcc tggaggcaca ccagactctt     1200

ctcaacaagt ggatccccac ctgcgcccag ctttttacct cacggaagga gcactggatt     1260

cattttgctc ccaagagcaa ctatgactca agtcgaaaca ttgaggaata ttttgcttct     1320

gtggcatcat tcatgtcgct gcagcttagg gagctggtca ttaagtcact tgaggacctc     1380

gtttcccttt tcatgataca caaagatggg aatgatttta aggagcccta ccaagagatg     1440

aagtttttca tacctcagct aatcatgatc aaacttgaag tcagtgaacc cattattgtc     1500

ttcaatccat cttttgatgg ctgctgggaa ttaatacgtg actctttcct ggaaattatt     1560

aagaactcta atgggatccc caagctgaaa tacataccac ttaagttctc cttcactgct     1620

gctgctgctg atcggcaatg tgtgaaagca gctgagccag gagagcccag catgcacgcg     1680

gctgccactg caatggcaga gctgaaagga tataatctgc tccttggaac tgttaacgca     1740

gaagaaaaac ttgtttctga ttttttgatt caaactttca aggtatttca gaaaaatcaa     1800

gttggcccct gcaaatattt aaatgtctac aaaaagtatg ttgacttatt ggataacacg     1860

gcagagcaaa acatcgctgc gttcctgaaa gaaaatcatg acattgatga ttttgtgacg     1920

aagatcaatg ccataaagaa acggagaaat gaaattgcat ccatgaacat caccgtgcct     1980

ttagccatgt tctgccttga tgctacggcc ctaaatcatg atctctgtga gcgagctcaa     2040

aatcttaaag accatctgat tcaattccaa gtggatgtaa accgagacac caataccagc     2100

atttgtaatc agtacagcca catcgcagac aaagtcagtg aggttcctgc caacactaag     2160

gagctggtat ccctcattga attcctaaag aaatccagtg ctgtcactgt gttcaaactc     2220

aggaggcaac ttagagatgc aagtgaacgg ctggagttcc tgatggacta tgcagacttg     2280

ccgtaccaga ttgaagatat ctttgacaac agccggaact tgctccttca caagagggat     2340

caggcagaaa tggatctgat taaaagatgc tcagaatttg agttgagact tgagggctac     2400

cacagagaac tggaaagttt taggaagcgc gaagtgatga ctacagaaga aatgaagcac     2460

aatgttgaaa agcttaatga gctttcaaag aacctaaatc gggcgtttgc agagtttgag     2520

ttgatcaata aggaggaaga gctattggaa aaggagaaga gtacttaccc tcttctgcag     2580

gccatgctga agaacaaagt accttatgag cagctgtggt cgacagccta tgagttcagc     2640

atcaagtcag aggaatggat gaatggaccc ctcttcttac tgaatgctga gcaaattgcg     2700

gaggagatag ggaatatgtg gaggacaacg tataaactga tcaagacctt gtctgatgtg     2760

cctgcaccca ggcgcttagc agagaatgtg aagatcaaga tcgataagtt caagcagtac     2820

attcccatcc tcagtatttc ctgcaaccca ggaatgaaag accgacactg gcagcagatc     2880

agtgagattg ttggctatga gataaagccc accgaaacga cctgcctctc aaatatgctc     2940

gaatttggat tcggcaaatt cgttgaaaaa ttggagccca ttggtgcagc tgccagcaag     3000

gaatactctc tggagaaaaa cttggataga atgaagttgg attgggttaa cgtgacgttc     3060

agcttcgtga aatacaggga cactgataca aacatcttgt gtgcaattga tgacattcaa     3120

atgctacttg atgatcacgt gataaagacc cagaccatgt gtggctcccc attcatcaaa     3180

ccaatagaag cagaatgccg gaaatgggaa gaaaagctaa ttcgcataca agacaatttg     3240

gatgcctggt tgaaatgcca agccacctgg ctgtacctgg aaccaatctt cagttcagag     3300

gacatcatag cccagatgcc agaagagggg aggaaatttg gcattgttga tagttactgg     3360

aaatcactta tgtcccaagc ggtgaaagat aacaggattc tggtggcagc cgaccagcca     3420

cggatggcag agaagcttca agaagccaac tttctcttgg aggacatcca gaaagggctg     3480

aatgattact tggagaagaa gagactattc ttccccagat tcttcttcct atcaaacgat     3540

gagctgctgg aaatcttgtc cgagacaaag gaccctctcc gagtgcagcc gcacttgaag     3600

aagtgctttg aaggaattgc caagcttgag tttacagaca atctggaaat tgtgggcatg     3660

atcagctcgg aaaaagaaac tgttccattc atacagaaaa tctacccagc taatgccaag     3720

ggcatggtgg aaaagtggct ccagcaggtg gagcagatga tgctggccag tatgcgagaa     3780

gtcattggac ttgggattga agcatatgtc aaggtccctc gaaatcactg ggtcttacag     3840

tggcctggac aggtggttat ctgtgtctcc tccatctttt ggacccagga ggtgtcccaa     3900

gccctggcgg aaaatacctt actggatttt ctgaaaaaga gcaatgatca gattgcgcag     3960

attgtccagc tggtgcgagg gaagctgagc agtggagctc gactcactct cggggccctc     4020

acggtcatcg atgtccacgc ccgcgacgtg gtggccaagt tatctgagga cagggtctcc     4080

gatctgaatg atttccaatg gatctcacag ctgcgctact actgggtggc caaggatgtg     4140

caggtgcaga ttatcaccac agaagccttg tatggctatg agtacctggg aaactccccc     4200

cggctggtga tcacacccct caccgaccgc tgctacagga cactgatggg agctttgaag     4260

ctgaaccttg ggggtgctcc agagggtcca gctgggactg gcaagacaga aaccaccaaa     4320

gatttggcca aagccttggc taagcagtgt gtggtcttca actgctccga tggtttggat     4380

tacaaagcta tggggaagtt cttcaagggg ctggcacagg ctggagcatg ggcgtgcttt     4440

gatgagttca acaggatcga ggtagaagtg ctgtctgtgg tcgctcagca gatcctcagc     4500

atccaacaag ccatcattcg gaagctaaag acattcatct ttgaagggac tgagctctct     4560

ctgaacccaa cctgcgctgt gttcatcacc atgaaccccg ggtatgctgg cagggctgaa     4620

ctgcccgaca atctcaaggc cttgttccgg acagtggcca tgatggtccc agattacgcc     4680

ctcattggag aaatctccct ctactccatg gggtttctgg actccagaag tctcgcccag     4740

aagatcgttg cgacctaccg cctgtgctcg gaacaactgt cctctcagca tcactatgac     4800

tacggtatgc gcgctgtcaa gtctgtgctt actgccgcag gaaacctgaa gctcaagtat     4860

ccagaggaga atgaaagtgt cctgctgctc cgggcattgc ttgatgtcaa tctggccaag     4920

ttcttagcgc aagatgtccc tctgtttcag ggaattatat ctgatttatt tcctggagtt     4980

gttcttccaa agccagacta tgaagttttt ctgaaagtgc tgaatgataa catcaaaaag     5040

atgaaactcc agccagtacc ttggtttata gggaaaatta tccagatcta cgaaatgatg     5100

ctggtgagac atggctatat gattgtagga gaccccatgg gcggcaagac ctctgcttat     5160

aaagtgttgg ctgcagctct cggcgattta cacgcagcca atcagatgga ggagtttgct     5220

gtggagtaca agatcatcaa ccccaaggct atcacgatgg ggcagctgta tgggtgcttt     5280

gaccaagtga gccacgagtg gatggatggt gtccttgcca atgctttccg ggagcaagcg     5340

tcttcactct ctgatgatcg caagtggatt atatttgatg ggccagtgga tgctatttgg     5400

attgaaaata tgaacactgt tctggatgac aataaaaagc tgtgtctcat gagtggggaa     5460

attatccaga tgaactccaa gatgagcctg atcttcgagc ccgccgacct cgagcaagcc     5520

tctccagcca ctgtgagcag gtgtgggatg atctacatgg agccccatca actaggctgg     5580

aagcccctga aggattccta catggacacc ctgccctcca gtctcaccaa ggagcacaaa     5640

gaattggtca atgacatgtt catgtggctt gtccagccct gcctggaatt tggtcgcctt     5700

cattgtaaat ttgttgtcca gacatctccc atccaccttg ccttctcaat gatgagactg     5760

tactcttctc tgcttgatga aatcagggca gtagaagagg aggaaatgga attaggtgaa     5820

ggcctgtcaa gtcaacagat ctttctctgg ctccaaggac tgtttctctt ttccttggtg     5880

tggaccgtgg ctggcaccat caacgcagac agcagaaaga aatttgatgt gtttttccgc     5940

aacctgatca tgggcatgga tgataaccac ccaaggccca aaagcgtcaa actcaccaaa     6000

aacaacatct ttccagaaag aggaagcatc tatgattttt attttatcaa acaagctagt     6060

ggacattggg aaacgtggac acagtatatc accaaagagg aggaaaaagt tccagctggt     6120

gcaaaggtct cagaactcat catccccaca atggagacag cccggcagtc cttcttcttg     6180

aaaacctact tagaccatga gattccaatg ctgttcgtgg gtcccacagg cactggcaaa     6240

tcagccatca ccaacaactt ccttctccac cttcccaaaa atacgtacct acccaactgc     6300

atcaatttct ctgccagaac ctcagccaat cagacccagg atatcatcat gtccaagctg     6360

gatcgacgac ggaagggcct tttcgggcct cccataggga agaaagcagt ggtgtttgtg     6420

gatgacctca acatgccagc caaagaggtg tatggggccc agccacccat cgagctcctg     6480

aggcagtgga ttgaccatgg ttactggttt gacaagaaag acacaaccag gctggacatc     6540

gtggacatgc tgctcgtgac agccatgggg ccccccgggg gaggaaggaa tgacattact     6600

ggacgattca ctcgccatct gaatatcatt tccatcaatg cctttgagga tgacatttta     6660

accaagattt tcagttcgat tgttgactgg cacttcggga aagggtttga tgtgatgttt     6720

ttaaggtacg gaaagatgct ggtccaagct actaagacaa tttatagaga tgcagtggag     6780

aacttcttgc caactccctc gaagtcacat tacgtcttta acctgcggga cttctcacga     6840

gtgattcaag gggtcctgct gtgccctcac acacacctgc aggatgtaga aaaatgtatc     6900

cggctttgga tccatgaggt ttatcgggtc ttctatgatc gtctgattga caaggaggac     6960

agacaggtct ttttcaacat ggtgaaggaa accacctcca attgcttcaa gcagaccata     7020

gagaaggtgc ttatccactt gtcacccact ggaaagatag tcgatgataa cattcgaagc     7080

ctcttctttg gagattattt caagccagaa agtgaccaaa aaatctacga tgagatcact     7140

gacctgaaac agctgactgt ggtcatggag cactatctgg aagaattcaa caacatcagc     7200

aaggccccca tgtccctggt catgttcagg tttgccattg agcacatctc taggatctgc     7260

cgtgtcctga agcaggacaa aggccacctg ctcctggtgg gcataggggg cagcgggcgg     7320

caaagtgccg ccaaactgtc cacattcatg aacgcatacg agctatacca gattgagatc     7380

accaagaact acgcaggcaa tgactggcga gaagatctta agaagatcat actgcaggtc     7440

ggtgtggcca ccaagagcac cgtgttcctc ttcgccgaca accagatcaa ggatgaatca     7500

ttcgtggagg acatcaacat gcttctgaac acaggtgacg tgcctaacat cttccctgct     7560

gacgagaagg ctgacatcgt ggagaagatg cagactgcag ccaggaccca aggagagaag     7620

gttgaagtca ctcctctttc tatgtataac ttctttattg agagggtaat taacaaaatc     7680

tccttttcat tagccatgag tccaataggg gatgccttca ggaaccgcct gcggatgttc     7740

ccttcgctga tcaattgctg tacgattgat tggttccagt cctggcccac agatgcccta     7800

gagttggtgg ctaacaaatt tctagaggat gtggagcttg atgacaacat tcgggtagag     7860

gtcgtgtcca tgtgcaaata tttccaagag agcgtcaaga agctgtcact cgattattac     7920

aacaaacttc gaagacacaa ctatgttacc cccacctcct accttgaatt gattctaacc     7980

ttcaagacgc tcctgaatag caagaggcaa gaggtggcta tgatgaggaa ccgctacctg     8040

acaggcttgc agaaactcga ctttgcagct tctcaggtag cggttatgca aagagaactg     8100

acagctcttc aacctcaact catcctcacc tccgaggaaa ctgccaagat gatggtgaaa     8160

attgaagcgg agacgagaga agctgatgga aagaaacttc tggtgcaggc agatgaaaaa     8220

gaagccaatg ttgctgctgc cattgcccaa ggaatcaaga acgaatgtga gggggaccta     8280

gctgaggcaa tgcctgcact cgaggctgca ctagctgctc tggacaccct gaacccggcc     8340

gacatctcgc tggtgaagtc gatgcagaac ccaccaggcc ctgtcaaact ggtcatggag     8400

agcatctgca tcatgaaagg gatgaagcca gagaggaagc cagaccccag tggctccggt     8460

aagatgatag aagattactg gggggtatcc aaaaagattc ttggggatct gaaattcttg     8520

gagagtctta agacatatga caaagacaac atccccccac tgaccatgaa gcggatccgg     8580

gaaaggttta tcaatcaccc ggaattccag ccagctgtca ttaaaaatgt atcgtcggcc     8640

tgcgagggtc tgtgcaagtg ggtgagggcc atggaggtgt acgatcgcgt ggccaaggtg     8700

gtggctccca aacgggagcg actgagggag gcagagggga agctggctgc acagatgcag     8760

aagctgaacc agaaaagagc agagctgaag ctggtggtag atcggctcca ggccctgaat     8820

gacgactttg aagagatgaa caccaagaaa aaggacttgg aggaaaacat tgaaatctgc     8880

tcccaaaagc tggtcagggc agagaaactg atcagtggtc ttgggggaga gaaggacaga     8940

tggaccgaag ctgcccgaca gctggggatc cgctatacta atctgactgg tgacgtgttg     9000

ctgtcctcag gaactgtggc ttacctgggc gcttttacag tggattatcg ggtccagtgc     9060

caaaatcagt ggttggctga atgtaaggac aaggtcatcc ctggcttcag tgacttcagt     9120

ctcagccaca cgttagggga tcccataaaa atccgtgcct ggcagattgc tgggcttccc     9180

gttgactcct tctccatcga caatggcatc attgtatcca attccagacg ctgggcctta     9240

atgattgacc ctcacgggca ggccaataaa tggattaaga acatggagaa ggcgaataaa     9300

ctggctgtca tcaagttctc tgatagcaac tacatgagga tgctggaaaa cgcgctgcag     9360

ttaggcaccc ctgtcttgat tgaaaacatt ggagaagagc tggatgcttc tatcgaacct     9420

atcttgctca aggcaacatt caaacagcaa ggagttgagt acatgaggct gggtgaaaac     9480

atcattgaat attccaggga ttttaagtta tacatcacaa cccgtttgag gaatccacat     9540

tacctcccag aagttgccgt gaaggtctgt ctcctcaact tcatgatcac ccccttgggt     9600

ctccaagatc aactccttgg catcgtggct gcgaaggaga agccagagct ggaagagaaa     9660

aagaaccagt tgattgtgga aagtgccaag aacaagaagc atctcaagga aattgaagat     9720

aagatcttgg aggttctctc catgtccaag ggtaacatcc tggaggatga aaccgccatc     9780

aaagttctgt cctcctccaa agtgctatct gaagagatct cagagaaaca gaaagttgct     9840

tccatgacag aaacgcagat tgacgagact cggatgggct acaagccagt ggctgtgcat     9900

tctgccacca tcttcttttg tatctcggac ctggccaaca tcgagccgat gtaccagtac     9960

tccctgactt ggttcataaa tctctacatg cattccttga cccacagcac gaagagcgag    10020

gaactgaatc tgcgcatcaa gtacatcatt gaccatttca ccctgagcat ctacaacaac    10080

gtgtgccgtt ctctgtttga gaaggacaag ctactcttct ctctcctcct gaccatcggc    10140

atcatgaaac agaagaagga aattacggag gaggtgtggt acttccttct cactggaggc    10200

atcgcactgg ataaccccta ccccaatcca gctccccaat ggctgtctga gaaggcatgg    10260

gcagagattg tccgtgcatc tgccttaccc aaactgcatg gcctgatgga gcatttggaa    10320

cagaacctgg gtgaatggaa gctgatctat gactcggcct ggccccatga ggagcaactc    10380

cctgggtctt ggaagttctc tcaaggattg gagaagatgg tgatccttcg atgtttgcgg    10440

cctgacaaaa tggtgccagc ggtccgggag ttcattgctg aacatatggg aaagctgtat    10500

atcgaagccc ctacgttcga tctccaggga tcctacaatg attccagctg ctgtgcgcct    10560

ttgatttttg tgttgtctcc aagtgcagac ccaatggcag gcctgctgaa gtttgctgat    10620

gatcttggta tgggaggtac cagaacacag accatctccc ttggccaagg ccaaggccct    10680

attgctgcca aaatgatcaa caatgccatc aaagacggga cctgggtggt cttacagaac    10740

tgccacctgg ccgcaagctg gatgcctacc ctggagaaga tttgtgagga ggtgattgtt    10800

cctgagagca ccaatgccag attcagactc tggctaacca gctatccatc agagaagttt    10860

ccagtcagca ttctccagaa tggaatcaaa atgaccaatg agccccccaa agggctccgg    10920

gccaacctgt tgcgctccta cctcaatgac cccatctcag atcctgtgtt cttccaaagc    10980

tgtgcaaagg cggtgatgtg gcaaaagatg ttatttggcc tttgtttctt ccacgccgtt    11040

gttcaagaga gaagaaactt cggcccccta gggtggaata ttccctatga attcaacgaa    11100

tctgacctga ggattagtat gtggcagatc cagatgtttc tcaatgacta caaggaggtg    11160

ccctttgatg ctctgaccta cctgacaggg gaatgtaatt acggaggcag agtgactgat    11220

gacaaagacc ggcgtctcct gctgtcactt ctgtccatgt tctactgtaa ggaaattgag    11280

gaggactatt actccctcgc tcctggagac acttactaca tccctcctca tggctcctac    11340

cagtcctata tcgactatct caggaatctc cccatcacag cccacccaga agtgttcggc    11400

ctccatgaga acgcagacat caccaaagac aaccaggaaa ccaaccagct gtttgagggg    11460

gtcctgctga ccctccctag acagtcagga ggaagtggca agtcccctca ggaagtggtt    11520

gaggagttgg cacaagacat tctctccaag cttcccagag actttgacct ggaagaggtc    11580

atgaagttgt accccgtggt ctatgaagaa tccatgaata ccgtcctaag gcaggagctc    11640

atcagattca acaggctgac caaagtggtt cggaggagcc tcatcaatct tggccgagcc    11700

atcaaaggac aggtcctgat gtcctcggag ctagaggaag tctttaacag catgcttgtg    11760

ggtaaagtgc cagccatgtg ggcagccaag tcttacccat cactgaagcc tctggggggc    11820

tacgtggctg acctgctggc ccgcctgacc ttcttccagg aatggattga caaggggccc    11880

cctgtggtat tttggatctc tggattctac ttcacacagt cttttttgac tggcgtctct    11940

caaaattatg cccggaaata taccatcccc attgaccaca ttggatttga gtttgaggta    12000

accccacaag aaacagtgat ggagaataac cccgaagatg gggcctacat caaagggctc    12060

ttcttagaag gtgcccgttg ggacaggaaa acgatgcaga ttggggaatc tctccccaaa    12120

atcctctatg acccactgcc catcatttgg ctgaaacctg gggagagcgc aatgtttctg    12180

catcaggaca tctatgtgtg tccagtctac aaaacaagtg cccgcagagg aaccctctcc    12240

accacaggcc actctaccaa ctatgtcctc tccattgagc ttccaacaga catgccccag    12300

aagcactgga taaaccgagg ggtggcctca ctgtgccagc tggataactg a             12351


<210>  12
<211>  4116
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Ala Thr Gly Arg Leu Glu Leu Thr Leu Ala Ala Pro Pro His 
1               5                   10                  15      


Pro Gly Pro Ala Phe Gln Arg Ser Lys Ala Arg Glu Thr Gln Gly Glu 
            20                  25                  30          


Glu Glu Gly Ser Glu Met Gln Ile Ala Lys Ser Asp Ser Ile His His 
        35                  40                  45              


Met Ser His Ser Gln Gly Gln Pro Glu Leu Pro Pro Leu Pro Ala Ser 
    50                  55                  60                  


Ala Asn Glu Glu Pro Ser Gly Leu Tyr Gln Thr Val Met Ser His Ser 
65                  70                  75                  80  


Phe Tyr Pro Pro Leu Met Gln Arg Thr Ser Trp Thr Leu Ala Ala Pro 
                85                  90                  95      


Phe Lys Glu Gln His His His Arg Gly Pro Ser Asp Ser Ile Ala Asn 
            100                 105                 110         


Asn Tyr Ser Leu Met Ala Gln Asp Leu Lys Leu Lys Asp Leu Leu Lys 
        115                 120                 125             


Val Tyr Gln Pro Ala Thr Ile Ser Val Pro Arg Asp Arg Thr Gly Gln 
    130                 135                 140                 


Gly Leu Pro Ser Ser Gly Asn Arg Ser Ser Ser Glu Pro Met Arg Lys 
145                 150                 155                 160 


Lys Thr Lys Phe Ser Ser Arg Asn Lys Glu Asp Ser Thr Arg Ile Lys 
                165                 170                 175     


Leu Ala Phe Lys Thr Ser Ile Phe Ser Pro Met Lys Lys Glu Val Lys 
            180                 185                 190         


Thr Ser Leu Thr Phe Pro Gly Ser Arg Pro Met Ser Pro Glu Gln Gln 
        195                 200                 205             


Leu Asp Val Met Leu Gln Gln Glu Met Glu Met Glu Ser Lys Glu Lys 
    210                 215                 220                 


Lys Pro Ser Glu Ser Asp Leu Glu Arg Tyr Tyr Tyr Tyr Leu Thr Asn 
225                 230                 235                 240 


Gly Ile Arg Lys Asp Met Ile Ala Pro Glu Glu Gly Glu Val Met Val 
                245                 250                 255     


Arg Ile Ser Lys Leu Ile Ser Asn Thr Leu Leu Thr Ser Pro Phe Leu 
            260                 265                 270         


Glu Pro Leu Met Val Val Leu Val Gln Glu Lys Glu Asn Asp Tyr Tyr 
        275                 280                 285             


Cys Ser Leu Met Lys Ser Ile Val Asp Tyr Ile Leu Met Asp Pro Met 
    290                 295                 300                 


Glu Arg Lys Arg Leu Phe Ile Glu Ser Ile Pro Arg Leu Phe Pro Gln 
305                 310                 315                 320 


Arg Val Ile Arg Ala Pro Val Pro Trp His Ser Val Tyr Arg Ser Ala 
                325                 330                 335     


Lys Lys Trp Asn Glu Glu His Leu His Thr Val Asn Pro Met Met Leu 
            340                 345                 350         


Arg Leu Lys Glu Leu Trp Phe Ala Glu Phe Arg Asp Leu Arg Phe Val 
        355                 360                 365             


Arg Thr Ala Glu Ile Leu Ala Gly Lys Leu Pro Leu Gln Pro Gln Glu 
    370                 375                 380                 


Phe Trp Asp Val Ile Gln Lys His Cys Leu Glu Ala His Gln Thr Leu 
385                 390                 395                 400 


Leu Asn Lys Trp Ile Pro Thr Cys Ala Gln Leu Phe Thr Ser Arg Lys 
                405                 410                 415     


Glu His Trp Ile His Phe Ala Pro Lys Ser Asn Tyr Asp Ser Ser Arg 
            420                 425                 430         


Asn Ile Glu Glu Tyr Phe Ala Ser Val Ala Ser Phe Met Ser Leu Gln 
        435                 440                 445             


Leu Arg Glu Leu Val Ile Lys Ser Leu Glu Asp Leu Val Ser Leu Phe 
    450                 455                 460                 


Met Ile His Lys Asp Gly Asn Asp Phe Lys Glu Pro Tyr Gln Glu Met 
465                 470                 475                 480 


Lys Phe Phe Ile Pro Gln Leu Ile Met Ile Lys Leu Glu Val Ser Glu 
                485                 490                 495     


Pro Ile Ile Val Phe Asn Pro Ser Phe Asp Gly Cys Trp Glu Leu Ile 
            500                 505                 510         


Arg Asp Ser Phe Leu Glu Ile Ile Lys Asn Ser Asn Gly Ile Pro Lys 
        515                 520                 525             


Leu Lys Tyr Ile Pro Leu Lys Phe Ser Phe Thr Ala Ala Ala Ala Asp 
    530                 535                 540                 


Arg Gln Cys Val Lys Ala Ala Glu Pro Gly Glu Pro Ser Met His Ala 
545                 550                 555                 560 


Ala Ala Thr Ala Met Ala Glu Leu Lys Gly Tyr Asn Leu Leu Leu Gly 
                565                 570                 575     


Thr Val Asn Ala Glu Glu Lys Leu Val Ser Asp Phe Leu Ile Gln Thr 
            580                 585                 590         


Phe Lys Val Phe Gln Lys Asn Gln Val Gly Pro Cys Lys Tyr Leu Asn 
        595                 600                 605             


Val Tyr Lys Lys Tyr Val Asp Leu Leu Asp Asn Thr Ala Glu Gln Asn 
    610                 615                 620                 


Ile Ala Ala Phe Leu Lys Glu Asn His Asp Ile Asp Asp Phe Val Thr 
625                 630                 635                 640 


Lys Ile Asn Ala Ile Lys Lys Arg Arg Asn Glu Ile Ala Ser Met Asn 
                645                 650                 655     


Ile Thr Val Pro Leu Ala Met Phe Cys Leu Asp Ala Thr Ala Leu Asn 
            660                 665                 670         


His Asp Leu Cys Glu Arg Ala Gln Asn Leu Lys Asp His Leu Ile Gln 
        675                 680                 685             


Phe Gln Val Asp Val Asn Arg Asp Thr Asn Thr Ser Ile Cys Asn Gln 
    690                 695                 700                 


Tyr Ser His Ile Ala Asp Lys Val Ser Glu Val Pro Ala Asn Thr Lys 
705                 710                 715                 720 


Glu Leu Val Ser Leu Ile Glu Phe Leu Lys Lys Ser Ser Ala Val Thr 
                725                 730                 735     


Val Phe Lys Leu Arg Arg Gln Leu Arg Asp Ala Ser Glu Arg Leu Glu 
            740                 745                 750         


Phe Leu Met Asp Tyr Ala Asp Leu Pro Tyr Gln Ile Glu Asp Ile Phe 
        755                 760                 765             


Asp Asn Ser Arg Asn Leu Leu Leu His Lys Arg Asp Gln Ala Glu Met 
    770                 775                 780                 


Asp Leu Ile Lys Arg Cys Ser Glu Phe Glu Leu Arg Leu Glu Gly Tyr 
785                 790                 795                 800 


His Arg Glu Leu Glu Ser Phe Arg Lys Arg Glu Val Met Thr Thr Glu 
                805                 810                 815     


Glu Met Lys His Asn Val Glu Lys Leu Asn Glu Leu Ser Lys Asn Leu 
            820                 825                 830         


Asn Arg Ala Phe Ala Glu Phe Glu Leu Ile Asn Lys Glu Glu Glu Leu 
        835                 840                 845             


Leu Glu Lys Glu Lys Ser Thr Tyr Pro Leu Leu Gln Ala Met Leu Lys 
    850                 855                 860                 


Asn Lys Val Pro Tyr Glu Gln Leu Trp Ser Thr Ala Tyr Glu Phe Ser 
865                 870                 875                 880 


Ile Lys Ser Glu Glu Trp Met Asn Gly Pro Leu Phe Leu Leu Asn Ala 
                885                 890                 895     


Glu Gln Ile Ala Glu Glu Ile Gly Asn Met Trp Arg Thr Thr Tyr Lys 
            900                 905                 910         


Leu Ile Lys Thr Leu Ser Asp Val Pro Ala Pro Arg Arg Leu Ala Glu 
        915                 920                 925             


Asn Val Lys Ile Lys Ile Asp Lys Phe Lys Gln Tyr Ile Pro Ile Leu 
    930                 935                 940                 


Ser Ile Ser Cys Asn Pro Gly Met Lys Asp Arg His Trp Gln Gln Ile 
945                 950                 955                 960 


Ser Glu Ile Val Gly Tyr Glu Ile Lys Pro Thr Glu Thr Thr Cys Leu 
                965                 970                 975     


Ser Asn Met Leu Glu Phe Gly Phe Gly Lys Phe Val Glu Lys Leu Glu 
            980                 985                 990         


Pro Ile Gly Ala Ala Ala Ser Lys  Glu Tyr Ser Leu Glu  Lys Asn Leu 
        995                 1000                 1005             


Asp Arg  Met Lys Leu Asp Trp  Val Asn Val Thr Phe  Ser Phe Val 
    1010                 1015                 1020             


Lys Tyr  Arg Asp Thr Asp Thr  Asn Ile Leu Cys Ala  Ile Asp Asp 
    1025                 1030                 1035             


Ile Gln  Met Leu Leu Asp Asp  His Val Ile Lys Thr  Gln Thr Met 
    1040                 1045                 1050             


Cys Gly  Ser Pro Phe Ile Lys  Pro Ile Glu Ala Glu  Cys Arg Lys 
    1055                 1060                 1065             


Trp Glu  Glu Lys Leu Ile Arg  Ile Gln Asp Asn Leu  Asp Ala Trp 
    1070                 1075                 1080             


Leu Lys  Cys Gln Ala Thr Trp  Leu Tyr Leu Glu Pro  Ile Phe Ser 
    1085                 1090                 1095             


Ser Glu  Asp Ile Ile Ala Gln  Met Pro Glu Glu Gly  Arg Lys Phe 
    1100                 1105                 1110             


Gly Ile  Val Asp Ser Tyr Trp  Lys Ser Leu Met Ser  Gln Ala Val 
    1115                 1120                 1125             


Lys Asp  Asn Arg Ile Leu Val  Ala Ala Asp Gln Pro  Arg Met Ala 
    1130                 1135                 1140             


Glu Lys  Leu Gln Glu Ala Asn  Phe Leu Leu Glu Asp  Ile Gln Lys 
    1145                 1150                 1155             


Gly Leu  Asn Asp Tyr Leu Glu  Lys Lys Arg Leu Phe  Phe Pro Arg 
    1160                 1165                 1170             


Phe Phe  Phe Leu Ser Asn Asp  Glu Leu Leu Glu Ile  Leu Ser Glu 
    1175                 1180                 1185             


Thr Lys  Asp Pro Leu Arg Val  Gln Pro His Leu Lys  Lys Cys Phe 
    1190                 1195                 1200             


Glu Gly  Ile Ala Lys Leu Glu  Phe Thr Asp Asn Leu  Glu Ile Val 
    1205                 1210                 1215             


Gly Met  Ile Ser Ser Glu Lys  Glu Thr Val Pro Phe  Ile Gln Lys 
    1220                 1225                 1230             


Ile Tyr  Pro Ala Asn Ala Lys  Gly Met Val Glu Lys  Trp Leu Gln 
    1235                 1240                 1245             


Gln Val  Glu Gln Met Met Leu  Ala Ser Met Arg Glu  Val Ile Gly 
    1250                 1255                 1260             


Leu Gly  Ile Glu Ala Tyr Val  Lys Val Pro Arg Asn  His Trp Val 
    1265                 1270                 1275             


Leu Gln  Trp Pro Gly Gln Val  Val Ile Cys Val Ser  Ser Ile Phe 
    1280                 1285                 1290             


Trp Thr  Gln Glu Val Ser Gln  Ala Leu Ala Glu Asn  Thr Leu Leu 
    1295                 1300                 1305             


Asp Phe  Leu Lys Lys Ser Asn  Asp Gln Ile Ala Gln  Ile Val Gln 
    1310                 1315                 1320             


Leu Val  Arg Gly Lys Leu Ser  Ser Gly Ala Arg Leu  Thr Leu Gly 
    1325                 1330                 1335             


Ala Leu  Thr Val Ile Asp Val  His Ala Arg Asp Val  Val Ala Lys 
    1340                 1345                 1350             


Leu Ser  Glu Asp Arg Val Ser  Asp Leu Asn Asp Phe  Gln Trp Ile 
    1355                 1360                 1365             


Ser Gln  Leu Arg Tyr Tyr Trp  Val Ala Lys Asp Val  Gln Val Gln 
    1370                 1375                 1380             


Ile Ile  Thr Thr Glu Ala Leu  Tyr Gly Tyr Glu Tyr  Leu Gly Asn 
    1385                 1390                 1395             


Ser Pro  Arg Leu Val Ile Thr  Pro Leu Thr Asp Arg  Cys Tyr Arg 
    1400                 1405                 1410             


Thr Leu  Met Gly Ala Leu Lys  Leu Asn Leu Gly Gly  Ala Pro Glu 
    1415                 1420                 1425             


Gly Pro  Ala Gly Thr Gly Lys  Thr Glu Thr Thr Lys  Asp Leu Ala 
    1430                 1435                 1440             


Lys Ala  Leu Ala Lys Gln Cys  Val Val Phe Asn Cys  Ser Asp Gly 
    1445                 1450                 1455             


Leu Asp  Tyr Lys Ala Met Gly  Lys Phe Phe Lys Gly  Leu Ala Gln 
    1460                 1465                 1470             


Ala Gly  Ala Trp Ala Cys Phe  Asp Glu Phe Asn Arg  Ile Glu Val 
    1475                 1480                 1485             


Glu Val  Leu Ser Val Val Ala  Gln Gln Ile Leu Ser  Ile Gln Gln 
    1490                 1495                 1500             


Ala Ile  Ile Arg Lys Leu Lys  Thr Phe Ile Phe Glu  Gly Thr Glu 
    1505                 1510                 1515             


Leu Ser  Leu Asn Pro Thr Cys  Ala Val Phe Ile Thr  Met Asn Pro 
    1520                 1525                 1530             


Gly Tyr  Ala Gly Arg Ala Glu  Leu Pro Asp Asn Leu  Lys Ala Leu 
    1535                 1540                 1545             


Phe Arg  Thr Val Ala Met Met  Val Pro Asp Tyr Ala  Leu Ile Gly 
    1550                 1555                 1560             


Glu Ile  Ser Leu Tyr Ser Met  Gly Phe Leu Asp Ser  Arg Ser Leu 
    1565                 1570                 1575             


Ala Gln  Lys Ile Val Ala Thr  Tyr Arg Leu Cys Ser  Glu Gln Leu 
    1580                 1585                 1590             


Ser Ser  Gln His His Tyr Asp  Tyr Gly Met Arg Ala  Val Lys Ser 
    1595                 1600                 1605             


Val Leu  Thr Ala Ala Gly Asn  Leu Lys Leu Lys Tyr  Pro Glu Glu 
    1610                 1615                 1620             


Asn Glu  Ser Val Leu Leu Leu  Arg Ala Leu Leu Asp  Val Asn Leu 
    1625                 1630                 1635             


Ala Lys  Phe Leu Ala Gln Asp  Val Pro Leu Phe Gln  Gly Ile Ile 
    1640                 1645                 1650             


Ser Asp  Leu Phe Pro Gly Val  Val Leu Pro Lys Pro  Asp Tyr Glu 
    1655                 1660                 1665             


Val Phe  Leu Lys Val Leu Asn  Asp Asn Ile Lys Lys  Met Lys Leu 
    1670                 1675                 1680             


Gln Pro  Val Pro Trp Phe Ile  Gly Lys Ile Ile Gln  Ile Tyr Glu 
    1685                 1690                 1695             


Met Met  Leu Val Arg His Gly  Tyr Met Ile Val Gly  Asp Pro Met 
    1700                 1705                 1710             


Gly Gly  Lys Thr Ser Ala Tyr  Lys Val Leu Ala Ala  Ala Leu Gly 
    1715                 1720                 1725             


Asp Leu  His Ala Ala Asn Gln  Met Glu Glu Phe Ala  Val Glu Tyr 
    1730                 1735                 1740             


Lys Ile  Ile Asn Pro Lys Ala  Ile Thr Met Gly Gln  Leu Tyr Gly 
    1745                 1750                 1755             


Cys Phe  Asp Gln Val Ser His  Glu Trp Met Asp Gly  Val Leu Ala 
    1760                 1765                 1770             


Asn Ala  Phe Arg Glu Gln Ala  Ser Ser Leu Ser Asp  Asp Arg Lys 
    1775                 1780                 1785             


Trp Ile  Ile Phe Asp Gly Pro  Val Asp Ala Ile Trp  Ile Glu Asn 
    1790                 1795                 1800             


Met Asn  Thr Val Leu Asp Asp  Asn Lys Lys Leu Cys  Leu Met Ser 
    1805                 1810                 1815             


Gly Glu  Ile Ile Gln Met Asn  Ser Lys Met Ser Leu  Ile Phe Glu 
    1820                 1825                 1830             


Pro Ala  Asp Leu Glu Gln Ala  Ser Pro Ala Thr Val  Ser Arg Cys 
    1835                 1840                 1845             


Gly Met  Ile Tyr Met Glu Pro  His Gln Leu Gly Trp  Lys Pro Leu 
    1850                 1855                 1860             


Lys Asp  Ser Tyr Met Asp Thr  Leu Pro Ser Ser Leu  Thr Lys Glu 
    1865                 1870                 1875             


His Lys  Glu Leu Val Asn Asp  Met Phe Met Trp Leu  Val Gln Pro 
    1880                 1885                 1890             


Cys Leu  Glu Phe Gly Arg Leu  His Cys Lys Phe Val  Val Gln Thr 
    1895                 1900                 1905             


Ser Pro  Ile His Leu Ala Phe  Ser Met Met Arg Leu  Tyr Ser Ser 
    1910                 1915                 1920             


Leu Leu  Asp Glu Ile Arg Ala  Val Glu Glu Glu Glu  Met Glu Leu 
    1925                 1930                 1935             


Gly Glu  Gly Leu Ser Ser Gln  Gln Ile Phe Leu Trp  Leu Gln Gly 
    1940                 1945                 1950             


Leu Phe  Leu Phe Ser Leu Val  Trp Thr Val Ala Gly  Thr Ile Asn 
    1955                 1960                 1965             


Ala Asp  Ser Arg Lys Lys Phe  Asp Val Phe Phe Arg  Asn Leu Ile 
    1970                 1975                 1980             


Met Gly  Met Asp Asp Asn His  Pro Arg Pro Lys Ser  Val Lys Leu 
    1985                 1990                 1995             


Thr Lys  Asn Asn Ile Phe Pro  Glu Arg Gly Ser Ile  Tyr Asp Phe 
    2000                 2005                 2010             


Tyr Phe  Ile Lys Gln Ala Ser  Gly His Trp Glu Thr  Trp Thr Gln 
    2015                 2020                 2025             


Tyr Ile  Thr Lys Glu Glu Glu  Lys Val Pro Ala Gly  Ala Lys Val 
    2030                 2035                 2040             


Ser Glu  Leu Ile Ile Pro Thr  Met Glu Thr Ala Arg  Gln Ser Phe 
    2045                 2050                 2055             


Phe Leu  Lys Thr Tyr Leu Asp  His Glu Ile Pro Met  Leu Phe Val 
    2060                 2065                 2070             


Gly Pro  Thr Gly Thr Gly Lys  Ser Ala Ile Thr Asn  Asn Phe Leu 
    2075                 2080                 2085             


Leu His  Leu Pro Lys Asn Thr  Tyr Leu Pro Asn Cys  Ile Asn Phe 
    2090                 2095                 2100             


Ser Ala  Arg Thr Ser Ala Asn  Gln Thr Gln Asp Ile  Ile Met Ser 
    2105                 2110                 2115             


Lys Leu  Asp Arg Arg Arg Lys  Gly Leu Phe Gly Pro  Pro Ile Gly 
    2120                 2125                 2130             


Lys Lys  Ala Val Val Phe Val  Asp Asp Leu Asn Met  Pro Ala Lys 
    2135                 2140                 2145             


Glu Val  Tyr Gly Ala Gln Pro  Pro Ile Glu Leu Leu  Arg Gln Trp 
    2150                 2155                 2160             


Ile Asp  His Gly Tyr Trp Phe  Asp Lys Lys Asp Thr  Thr Arg Leu 
    2165                 2170                 2175             


Asp Ile  Val Asp Met Leu Leu  Val Thr Ala Met Gly  Pro Pro Gly 
    2180                 2185                 2190             


Gly Gly  Arg Asn Asp Ile Thr  Gly Arg Phe Thr Arg  His Leu Asn 
    2195                 2200                 2205             


Ile Ile  Ser Ile Asn Ala Phe  Glu Asp Asp Ile Leu  Thr Lys Ile 
    2210                 2215                 2220             


Phe Ser  Ser Ile Val Asp Trp  His Phe Gly Lys Gly  Phe Asp Val 
    2225                 2230                 2235             


Met Phe  Leu Arg Tyr Gly Lys  Met Leu Val Gln Ala  Thr Lys Thr 
    2240                 2245                 2250             


Ile Tyr  Arg Asp Ala Val Glu  Asn Phe Leu Pro Thr  Pro Ser Lys 
    2255                 2260                 2265             


Ser His  Tyr Val Phe Asn Leu  Arg Asp Phe Ser Arg  Val Ile Gln 
    2270                 2275                 2280             


Gly Val  Leu Leu Cys Pro His  Thr His Leu Gln Asp  Val Glu Lys 
    2285                 2290                 2295             


Cys Ile  Arg Leu Trp Ile His  Glu Val Tyr Arg Val  Phe Tyr Asp 
    2300                 2305                 2310             


Arg Leu  Ile Asp Lys Glu Asp  Arg Gln Val Phe Phe  Asn Met Val 
    2315                 2320                 2325             


Lys Glu  Thr Thr Ser Asn Cys  Phe Lys Gln Thr Ile  Glu Lys Val 
    2330                 2335                 2340             


Leu Ile  His Leu Ser Pro Thr  Gly Lys Ile Val Asp  Asp Asn Ile 
    2345                 2350                 2355             


Arg Ser  Leu Phe Phe Gly Asp  Tyr Phe Lys Pro Glu  Ser Asp Gln 
    2360                 2365                 2370             


Lys Ile  Tyr Asp Glu Ile Thr  Asp Leu Lys Gln Leu  Thr Val Val 
    2375                 2380                 2385             


Met Glu  His Tyr Leu Glu Glu  Phe Asn Asn Ile Ser  Lys Ala Pro 
    2390                 2395                 2400             


Met Ser  Leu Val Met Phe Arg  Phe Ala Ile Glu His  Ile Ser Arg 
    2405                 2410                 2415             


Ile Cys  Arg Val Leu Lys Gln  Asp Lys Gly His Leu  Leu Leu Val 
    2420                 2425                 2430             


Gly Ile  Gly Gly Ser Gly Arg  Gln Ser Ala Ala Lys  Leu Ser Thr 
    2435                 2440                 2445             


Phe Met  Asn Ala Tyr Glu Leu  Tyr Gln Ile Glu Ile  Thr Lys Asn 
    2450                 2455                 2460             


Tyr Ala  Gly Asn Asp Trp Arg  Glu Asp Leu Lys Lys  Ile Ile Leu 
    2465                 2470                 2475             


Gln Val  Gly Val Ala Thr Lys  Ser Thr Val Phe Leu  Phe Ala Asp 
    2480                 2485                 2490             


Asn Gln  Ile Lys Asp Glu Ser  Phe Val Glu Asp Ile  Asn Met Leu 
    2495                 2500                 2505             


Leu Asn  Thr Gly Asp Val Pro  Asn Ile Phe Pro Ala  Asp Glu Lys 
    2510                 2515                 2520             


Ala Asp  Ile Val Glu Lys Met  Gln Thr Ala Ala Arg  Thr Gln Gly 
    2525                 2530                 2535             


Glu Lys  Val Glu Val Thr Pro  Leu Ser Met Tyr Asn  Phe Phe Ile 
    2540                 2545                 2550             


Glu Arg  Val Ile Asn Lys Ile  Ser Phe Ser Leu Ala  Met Ser Pro 
    2555                 2560                 2565             


Ile Gly  Asp Ala Phe Arg Asn  Arg Leu Arg Met Phe  Pro Ser Leu 
    2570                 2575                 2580             


Ile Asn  Cys Cys Thr Ile Asp  Trp Phe Gln Ser Trp  Pro Thr Asp 
    2585                 2590                 2595             


Ala Leu  Glu Leu Val Ala Asn  Lys Phe Leu Glu Asp  Val Glu Leu 
    2600                 2605                 2610             


Asp Asp  Asn Ile Arg Val Glu  Val Val Ser Met Cys  Lys Tyr Phe 
    2615                 2620                 2625             


Gln Glu  Ser Val Lys Lys Leu  Ser Leu Asp Tyr Tyr  Asn Lys Leu 
    2630                 2635                 2640             


Arg Arg  His Asn Tyr Val Thr  Pro Thr Ser Tyr Leu  Glu Leu Ile 
    2645                 2650                 2655             


Leu Thr  Phe Lys Thr Leu Leu  Asn Ser Lys Arg Gln  Glu Val Ala 
    2660                 2665                 2670             


Met Met  Arg Asn Arg Tyr Leu  Thr Gly Leu Gln Lys  Leu Asp Phe 
    2675                 2680                 2685             


Ala Ala  Ser Gln Val Ala Val  Met Gln Arg Glu Leu  Thr Ala Leu 
    2690                 2695                 2700             


Gln Pro  Gln Leu Ile Leu Thr  Ser Glu Glu Thr Ala  Lys Met Met 
    2705                 2710                 2715             


Val Lys  Ile Glu Ala Glu Thr  Arg Glu Ala Asp Gly  Lys Lys Leu 
    2720                 2725                 2730             


Leu Val  Gln Ala Asp Glu Lys  Glu Ala Asn Val Ala  Ala Ala Ile 
    2735                 2740                 2745             


Ala Gln  Gly Ile Lys Asn Glu  Cys Glu Gly Asp Leu  Ala Glu Ala 
    2750                 2755                 2760             


Met Pro  Ala Leu Glu Ala Ala  Leu Ala Ala Leu Asp  Thr Leu Asn 
    2765                 2770                 2775             


Pro Ala  Asp Ile Ser Leu Val  Lys Ser Met Gln Asn  Pro Pro Gly 
    2780                 2785                 2790             


Pro Val  Lys Leu Val Met Glu  Ser Ile Cys Ile Met  Lys Gly Met 
    2795                 2800                 2805             


Lys Pro  Glu Arg Lys Pro Asp  Pro Ser Gly Ser Gly  Lys Met Ile 
    2810                 2815                 2820             


Glu Asp  Tyr Trp Gly Val Ser  Lys Lys Ile Leu Gly  Asp Leu Lys 
    2825                 2830                 2835             


Phe Leu  Glu Ser Leu Lys Thr  Tyr Asp Lys Asp Asn  Ile Pro Pro 
    2840                 2845                 2850             


Leu Thr  Met Lys Arg Ile Arg  Glu Arg Phe Ile Asn  His Pro Glu 
    2855                 2860                 2865             


Phe Gln  Pro Ala Val Ile Lys  Asn Val Ser Ser Ala  Cys Glu Gly 
    2870                 2875                 2880             


Leu Cys  Lys Trp Val Arg Ala  Met Glu Val Tyr Asp  Arg Val Ala 
    2885                 2890                 2895             


Lys Val  Val Ala Pro Lys Arg  Glu Arg Leu Arg Glu  Ala Glu Gly 
    2900                 2905                 2910             


Lys Leu  Ala Ala Gln Met Gln  Lys Leu Asn Gln Lys  Arg Ala Glu 
    2915                 2920                 2925             


Leu Lys  Leu Val Val Asp Arg  Leu Gln Ala Leu Asn  Asp Asp Phe 
    2930                 2935                 2940             


Glu Glu  Met Asn Thr Lys Lys  Lys Asp Leu Glu Glu  Asn Ile Glu 
    2945                 2950                 2955             


Ile Cys  Ser Gln Lys Leu Val  Arg Ala Glu Lys Leu  Ile Ser Gly 
    2960                 2965                 2970             


Leu Gly  Gly Glu Lys Asp Arg  Trp Thr Glu Ala Ala  Arg Gln Leu 
    2975                 2980                 2985             


Gly Ile  Arg Tyr Thr Asn Leu  Thr Gly Asp Val Leu  Leu Ser Ser 
    2990                 2995                 3000             


Gly Thr  Val Ala Tyr Leu Gly  Ala Phe Thr Val Asp  Tyr Arg Val 
    3005                 3010                 3015             


Gln Cys  Gln Asn Gln Trp Leu  Ala Glu Cys Lys Asp  Lys Val Ile 
    3020                 3025                 3030             


Pro Gly  Phe Ser Asp Phe Ser  Leu Ser His Thr Leu  Gly Asp Pro 
    3035                 3040                 3045             


Ile Lys  Ile Arg Ala Trp Gln  Ile Ala Gly Leu Pro  Val Asp Ser 
    3050                 3055                 3060             


Phe Ser  Ile Asp Asn Gly Ile  Ile Val Ser Asn Ser  Arg Arg Trp 
    3065                 3070                 3075             


Ala Leu  Met Ile Asp Pro His  Gly Gln Ala Asn Lys  Trp Ile Lys 
    3080                 3085                 3090             


Asn Met  Glu Lys Ala Asn Lys  Leu Ala Val Ile Lys  Phe Ser Asp 
    3095                 3100                 3105             


Ser Asn  Tyr Met Arg Met Leu  Glu Asn Ala Leu Gln  Leu Gly Thr 
    3110                 3115                 3120             


Pro Val  Leu Ile Glu Asn Ile  Gly Glu Glu Leu Asp  Ala Ser Ile 
    3125                 3130                 3135             


Glu Pro  Ile Leu Leu Lys Ala  Thr Phe Lys Gln Gln  Gly Val Glu 
    3140                 3145                 3150             


Tyr Met  Arg Leu Gly Glu Asn  Ile Ile Glu Tyr Ser  Arg Asp Phe 
    3155                 3160                 3165             


Lys Leu  Tyr Ile Thr Thr Arg  Leu Arg Asn Pro His  Tyr Leu Pro 
    3170                 3175                 3180             


Glu Val  Ala Val Lys Val Cys  Leu Leu Asn Phe Met  Ile Thr Pro 
    3185                 3190                 3195             


Leu Gly  Leu Gln Asp Gln Leu  Leu Gly Ile Val Ala  Ala Lys Glu 
    3200                 3205                 3210             


Lys Pro  Glu Leu Glu Glu Lys  Lys Asn Gln Leu Ile  Val Glu Ser 
    3215                 3220                 3225             


Ala Lys  Asn Lys Lys His Leu  Lys Glu Ile Glu Asp  Lys Ile Leu 
    3230                 3235                 3240             


Glu Val  Leu Ser Met Ser Lys  Gly Asn Ile Leu Glu  Asp Glu Thr 
    3245                 3250                 3255             


Ala Ile  Lys Val Leu Ser Ser  Ser Lys Val Leu Ser  Glu Glu Ile 
    3260                 3265                 3270             


Ser Glu  Lys Gln Lys Val Ala  Ser Met Thr Glu Thr  Gln Ile Asp 
    3275                 3280                 3285             


Glu Thr  Arg Met Gly Tyr Lys  Pro Val Ala Val His  Ser Ala Thr 
    3290                 3295                 3300             


Ile Phe  Phe Cys Ile Ser Asp  Leu Ala Asn Ile Glu  Pro Met Tyr 
    3305                 3310                 3315             


Gln Tyr  Ser Leu Thr Trp Phe  Ile Asn Leu Tyr Met  His Ser Leu 
    3320                 3325                 3330             


Thr His  Ser Thr Lys Ser Glu  Glu Leu Asn Leu Arg  Ile Lys Tyr 
    3335                 3340                 3345             


Ile Ile  Asp His Phe Thr Leu  Ser Ile Tyr Asn Asn  Val Cys Arg 
    3350                 3355                 3360             


Ser Leu  Phe Glu Lys Asp Lys  Leu Leu Phe Ser Leu  Leu Leu Thr 
    3365                 3370                 3375             


Ile Gly  Ile Met Lys Gln Lys  Lys Glu Ile Thr Glu  Glu Val Trp 
    3380                 3385                 3390             


Tyr Phe  Leu Leu Thr Gly Gly  Ile Ala Leu Asp Asn  Pro Tyr Pro 
    3395                 3400                 3405             


Asn Pro  Ala Pro Gln Trp Leu  Ser Glu Lys Ala Trp  Ala Glu Ile 
    3410                 3415                 3420             


Val Arg  Ala Ser Ala Leu Pro  Lys Leu His Gly Leu  Met Glu His 
    3425                 3430                 3435             


Leu Glu  Gln Asn Leu Gly Glu  Trp Lys Leu Ile Tyr  Asp Ser Ala 
    3440                 3445                 3450             


Trp Pro  His Glu Glu Gln Leu  Pro Gly Ser Trp Lys  Phe Ser Gln 
    3455                 3460                 3465             


Gly Leu  Glu Lys Met Val Ile  Leu Arg Cys Leu Arg  Pro Asp Lys 
    3470                 3475                 3480             


Met Val  Pro Ala Val Arg Glu  Phe Ile Ala Glu His  Met Gly Lys 
    3485                 3490                 3495             


Leu Tyr  Ile Glu Ala Pro Thr  Phe Asp Leu Gln Gly  Ser Tyr Asn 
    3500                 3505                 3510             


Asp Ser  Ser Cys Cys Ala Pro  Leu Ile Phe Val Leu  Ser Pro Ser 
    3515                 3520                 3525             


Ala Asp  Pro Met Ala Gly Leu  Leu Lys Phe Ala Asp  Asp Leu Gly 
    3530                 3535                 3540             


Met Gly  Gly Thr Arg Thr Gln  Thr Ile Ser Leu Gly  Gln Gly Gln 
    3545                 3550                 3555             


Gly Pro  Ile Ala Ala Lys Met  Ile Asn Asn Ala Ile  Lys Asp Gly 
    3560                 3565                 3570             


Thr Trp  Val Val Leu Gln Asn  Cys His Leu Ala Ala  Ser Trp Met 
    3575                 3580                 3585             


Pro Thr  Leu Glu Lys Ile Cys  Glu Glu Val Ile Val  Pro Glu Ser 
    3590                 3595                 3600             


Thr Asn  Ala Arg Phe Arg Leu  Trp Leu Thr Ser Tyr  Pro Ser Glu 
    3605                 3610                 3615             


Lys Phe  Pro Val Ser Ile Leu  Gln Asn Gly Ile Lys  Met Thr Asn 
    3620                 3625                 3630             


Glu Pro  Pro Lys Gly Leu Arg  Ala Asn Leu Leu Arg  Ser Tyr Leu 
    3635                 3640                 3645             


Asn Asp  Pro Ile Ser Asp Pro  Val Phe Phe Gln Ser  Cys Ala Lys 
    3650                 3655                 3660             


Ala Val  Met Trp Gln Lys Met  Leu Phe Gly Leu Cys  Phe Phe His 
    3665                 3670                 3675             


Ala Val  Val Gln Glu Arg Arg  Asn Phe Gly Pro Leu  Gly Trp Asn 
    3680                 3685                 3690             


Ile Pro  Tyr Glu Phe Asn Glu  Ser Asp Leu Arg Ile  Ser Met Trp 
    3695                 3700                 3705             


Gln Ile  Gln Met Phe Leu Asn  Asp Tyr Lys Glu Val  Pro Phe Asp 
    3710                 3715                 3720             


Ala Leu  Thr Tyr Leu Thr Gly  Glu Cys Asn Tyr Gly  Gly Arg Val 
    3725                 3730                 3735             


Thr Asp  Asp Lys Asp Arg Arg  Leu Leu Leu Ser Leu  Leu Ser Met 
    3740                 3745                 3750             


Phe Tyr  Cys Lys Glu Ile Glu  Glu Asp Tyr Tyr Ser  Leu Ala Pro 
    3755                 3760                 3765             


Gly Asp  Thr Tyr Tyr Ile Pro  Pro His Gly Ser Tyr  Gln Ser Tyr 
    3770                 3775                 3780             


Ile Asp  Tyr Leu Arg Asn Leu  Pro Ile Thr Ala His  Pro Glu Val 
    3785                 3790                 3795             


Phe Gly  Leu His Glu Asn Ala  Asp Ile Thr Lys Asp  Asn Gln Glu 
    3800                 3805                 3810             


Thr Asn  Gln Leu Phe Glu Gly  Val Leu Leu Thr Leu  Pro Arg Gln 
    3815                 3820                 3825             


Ser Gly  Gly Ser Gly Lys Ser  Pro Gln Glu Val Val  Glu Glu Leu 
    3830                 3835                 3840             


Ala Gln  Asp Ile Leu Ser Lys  Leu Pro Arg Asp Phe  Asp Leu Glu 
    3845                 3850                 3855             


Glu Val  Met Lys Leu Tyr Pro  Val Val Tyr Glu Glu  Ser Met Asn 
    3860                 3865                 3870             


Thr Val  Leu Arg Gln Glu Leu  Ile Arg Phe Asn Arg  Leu Thr Lys 
    3875                 3880                 3885             


Val Val  Arg Arg Ser Leu Ile  Asn Leu Gly Arg Ala  Ile Lys Gly 
    3890                 3895                 3900             


Gln Val  Leu Met Ser Ser Glu  Leu Glu Glu Val Phe  Asn Ser Met 
    3905                 3910                 3915             


Leu Val  Gly Lys Val Pro Ala  Met Trp Ala Ala Lys  Ser Tyr Pro 
    3920                 3925                 3930             


Ser Leu  Lys Pro Leu Gly Gly  Tyr Val Ala Asp Leu  Leu Ala Arg 
    3935                 3940                 3945             


Leu Thr  Phe Phe Gln Glu Trp  Ile Asp Lys Gly Pro  Pro Val Val 
    3950                 3955                 3960             


Phe Trp  Ile Ser Gly Phe Tyr  Phe Thr Gln Ser Phe  Leu Thr Gly 
    3965                 3970                 3975             


Val Ser  Gln Asn Tyr Ala Arg  Lys Tyr Thr Ile Pro  Ile Asp His 
    3980                 3985                 3990             


Ile Gly  Phe Glu Phe Glu Val  Thr Pro Gln Glu Thr  Val Met Glu 
    3995                 4000                 4005             


Asn Asn  Pro Glu Asp Gly Ala  Tyr Ile Lys Gly Leu  Phe Leu Glu 
    4010                 4015                 4020             


Gly Ala  Arg Trp Asp Arg Lys  Thr Met Gln Ile Gly  Glu Ser Leu 
    4025                 4030                 4035             


Pro Lys  Ile Leu Tyr Asp Pro  Leu Pro Ile Ile Trp  Leu Lys Pro 
    4040                 4045                 4050             


Gly Glu  Ser Ala Met Phe Leu  His Gln Asp Ile Tyr  Val Cys Pro 
    4055                 4060                 4065             


Val Tyr  Lys Thr Ser Ala Arg  Arg Gly Thr Leu Ser  Thr Thr Gly 
    4070                 4075                 4080             


His Ser  Thr Asn Tyr Val Leu  Ser Ile Glu Leu Pro  Thr Asp Met 
    4085                 4090                 4095             


Pro Gln  Lys His Trp Ile Asn  Arg Gly Val Ala Ser  Leu Cys Gln 
    4100                 4105                 4110             


Leu Asp  Asn 
    4115     


<210>  13
<211>  2297
<212>  DNA
<213>  Homo sapiens

<400>  13
aggatcagac tttttaaatg tttggaattc aagatacttt aggaagagga ccaactctga       60

aagagaaatc gctgggcgcg gagatggatt cggtcaggtc ctgggtccgg aatgtcggag      120

tggtggacgc taatgtcgcc gcgcagagcg gggtcgccct gtcccgggcc cactttgaga      180

aacagcctcc ttccaacttg aggaaatcca acttctttca cttcgtcctg gcgctctatg      240

acaggcaggg ccagccggtg gagatcgagc ggacggcctt cgtggacttt gtggagaatg      300

acaaagaaca aggcaacgag aagaccaaca acggcactca ctacaagtta cagctcctct      360

acagcaacgg tgtccgcacg gaacaggacc tctatgtcag gctcatcgac tcggtcacca      420

agcagcccat cgcttacgag ggacagaata agaatccgga aatgtgccga gttctcctga      480

cgcacgaagt gatgtgtagt cgatgctgcg aaaagaaaag ctgtggaaac cgaaatgaga      540

ctccatcgga cccagtcata attgacagat tctttttaaa atttttcctc aagtgcaatc      600

agaattgttt gaaaacagca ggaaacccaa gggacatgag acggtttcag gttgtgttgt      660

caacaacggt gaatgtggat ggacacgtcc tggctgtttc tgacaacatg tttgttcata      720

acaactccaa gcatggacgg agagcaagaa gactcgatcc atcggaagct accccctgca      780

tcaaagccat tagcccgagt gaaggctgga ccacaggagg agccatggtc atcatcatcg      840

gggacaactt ctttgatggt ctccaagtgg tgtttgggac tatgcttgta tggagcgagc      900

taataacccc tcatgccatc agagtacaga ctcctccccg gcacatccca ggcgtggtag      960

aggtgacatt atcttataaa tctaaacagt tctgcaaagg agccccagga aggttcattt     1020

acacagcatt aaatgaaccc accatagact atggcttcca gagactgcag aaggtcatcc     1080

ctaggcatcc tggagatcct gagagattag ctaaggagat gctgttgaaa agagctgcag     1140

atctagtgga agctctttat ggcacaccac acaataacca ggacatcatt ttgaagcgag     1200

ccgcagacat tgctgaagct ctctacagcg tccccaggaa tcccagccag cttccagccc     1260

tctctagctc cccagcgcac agtggcatga tgggaatcaa ctcctatggc agccagcttg     1320

gggtcagcat ctcagagtca acacaaggaa ataatcaagg gtacatccgc aacacaagca     1380

gcatctctcc gcggggatac tcttccagct ccacgcctca acagtctaat tacagtacct     1440

ccagcaacag tatgaatggc tacagcaatg tccccatggc caacttgggt gttccaggtt     1500

caccaggatt tctaaatggc tcacccaccg gctctcctta tggaatcatg tcatcaagtc     1560

ccaccgttgg gtcttccagc acatcctcca tcctcccatt ttcctcttca gtttttcctg     1620

ctgtcaaaca gaagagtgcc tttgcccctg tcatcaggcc ccaaggctcc ccttcacctg     1680

cctgctccag cggcaatgga aatggattca gagccatgac cggacttgtt gtacccccga     1740

tgtaaagaag aactgctttc ttatagcaca aaactactta ctctgatgga ccaataatga     1800

agaaagcact aggagctctt ttgggggtgt agtggtgccc ccacatgaac atgatggaca     1860

cccttgggtc tgcaaggagc cagcatctta cttggtccca cgtcctccta tagctctgat     1920

ggtggctaca caaactgacc ctcttgggac aaggacaaaa gatgtcattg acgtagtcag     1980

tgctaagagc agaaatgcaa ttctttgtta tgaacattat gaaaaccacc ttcctatgtt     2040

tgtaaaatat ttaagaaaaa attggcaaac aattaatgct taatattttg gatactattt     2100

gtttttcttt gtaggaaaaa aaagttgaaa gtttctattt tctatgaagc ctttcagata     2160

ccaatttagt ttatgcagaa aaaaattgaa caaaacaggg taccagcacg gaagactttc     2220

ttaaaacgca acctgaattg aatgatgaaa tgttgtatgt gtgtttgctt atagcttaat     2280

ctctttaaaa aatgaac                                                    2297


<210>  14
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Phe Gly Ile Gln Asp Thr Leu Gly Arg Gly Pro Thr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Leu Gly Ala Glu Met Asp Ser Val Arg Ser Trp Val Arg Asn 
            20                  25                  30          


Val Gly Val Val Asp Ala Asn Val Ala Ala Gln Ser Gly Val Ala Leu 
        35                  40                  45              


Ser Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys Ser 
    50                  55                  60                  


Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln Pro 
65                  70                  75                  80  


Val Glu Ile Glu Arg Thr Ala Phe Val Asp Phe Val Glu Asn Asp Lys 
                85                  90                  95      


Glu Gln Gly Asn Glu Lys Thr Asn Asn Gly Thr His Tyr Lys Leu Gln 
            100                 105                 110         


Leu Leu Tyr Ser Asn Gly Val Arg Thr Glu Gln Asp Leu Tyr Val Arg 
        115                 120                 125             


Leu Ile Asp Ser Val Thr Lys Gln Pro Ile Ala Tyr Glu Gly Gln Asn 
    130                 135                 140                 


Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Val Met Cys 
145                 150                 155                 160 


Ser Arg Cys Cys Glu Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr Pro 
                165                 170                 175     


Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu Lys 
            180                 185                 190         


Cys Asn Gln Asn Cys Leu Lys Thr Ala Gly Asn Pro Arg Asp Met Arg 
        195                 200                 205             


Arg Phe Gln Val Val Leu Ser Thr Thr Val Asn Val Asp Gly His Val 
    210                 215                 220                 


Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His Gly 
225                 230                 235                 240 


Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Ala Thr Pro Cys Ile Lys 
                245                 250                 255     


Ala Ile Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly Ala Met Val Ile 
            260                 265                 270         


Ile Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Val Phe Gly Thr 
        275                 280                 285             


Met Leu Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg Val Gln 
    290                 295                 300                 


Thr Pro Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu Ser Tyr 
305                 310                 315                 320 


Lys Ser Lys Gln Phe Cys Lys Gly Ala Pro Gly Arg Phe Ile Tyr Thr 
                325                 330                 335     


Ala Leu Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu Gln Lys 
            340                 345                 350         


Val Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu Ala Lys Glu Met 
        355                 360                 365             


Leu Leu Lys Arg Ala Ala Asp Leu Val Glu Ala Leu Tyr Gly Thr Pro 
    370                 375                 380                 


His Asn Asn Gln Asp Ile Ile Leu Lys Arg Ala Ala Asp Ile Ala Glu 
385                 390                 395                 400 


Ala Leu Tyr Ser Val Pro Arg Asn Pro Ser Gln Leu Pro Ala Leu Ser 
                405                 410                 415     


Ser Ser Pro Ala His Ser Gly Met Met Gly Ile Asn Ser Tyr Gly Ser 
            420                 425                 430         


Gln Leu Gly Val Ser Ile Ser Glu Ser Thr Gln Gly Asn Asn Gln Gly 
        435                 440                 445             


Tyr Ile Arg Asn Thr Ser Ser Ile Ser Pro Arg Gly Tyr Ser Ser Ser 
    450                 455                 460                 


Ser Thr Pro Gln Gln Ser Asn Tyr Ser Thr Ser Ser Asn Ser Met Asn 
465                 470                 475                 480 


Gly Tyr Ser Asn Val Pro Met Ala Asn Leu Gly Val Pro Gly Ser Pro 
                485                 490                 495     


Gly Phe Leu Asn Gly Ser Pro Thr Gly Ser Pro Tyr Gly Ile Met Ser 
            500                 505                 510         


Ser Ser Pro Thr Val Gly Ser Ser Ser Thr Ser Ser Ile Leu Pro Phe 
        515                 520                 525             


Ser Ser Ser Val Phe Pro Ala Val Lys Gln Lys Ser Ala Phe Ala Pro 
    530                 535                 540                 


Val Ile Arg Pro Gln Gly Ser Pro Ser Pro Ala Cys Ser Ser Gly Asn 
545                 550                 555                 560 


Gly Asn Gly Phe Arg Ala Met Thr Gly Leu Val Val Pro Pro Met 
                565                 570                 575 


<210>  15
<211>  3727
<212>  DNA
<213>  Homo sapiens

<400>  15
aagtgagagc agcggcagcc ggcggtgcag cagccggccg acccagagtg taagtgcgtg       60

tgctggggcg agcgggagcg ggcgaggatg ggcacaggat agaggcagag ccacccacgc      120

cgccgcggcc ccacgctggg cgacagagcc tccagttccc cttcaatggt ggcgggtcgc      180

cggagctctg atcgccggga acccttgccg ctgctgtcct gcgaccccaa gcaggtatag      240

acacgtgtgg ccgtttacgc tgtaggatcc tcattcccac tggctttgaa cattttgggg      300

acttacaatg ccgccacccg cggacatcgt caaggtggcc atagaatggc cgggcgccta      360

ccccaaactc atggaaattg atcagaaaaa accactgtct gcaataataa aggaagtctg      420

tgatgggtgg tctcttgcca accatgaata ttttgcactc cagcatgccg atagttcaaa      480

cttctatatc acagaaaaga accgcaatga gataaaaaat ggcactatcc ttcgattaac      540

cacatctcca gctcagaacg cccagcagct ccatgaacga atccagtcct cgagtatgga      600

tgccaagctg gaagccctga aggacttggc cagcctctcc cgggatgtca cgtttgccca      660

ggagtttata aacctggacg gtatctctct cctcacgcag atggtggaga gcggcactga      720

gcgataccag aaattgcaga agatcatgaa gccttgcttt ggagacatgc tgtccttcac      780

cctgacggcc ttcgttgagc tgatggacca tggcatagtg tcctgggata cattttcggt      840

ggcgttcatt aagaagatag caagttttgt gaacaagtca gccatagaca tctcgatcct      900

gcagcggtcc ttggccattt tggagtcgat ggtgctcaat agccatgacc tctaccagaa      960

agtggcgcag gagatcacca tcggccagct cattccacac ctgcaagggt cagatcaaga     1020

aatccaaacc tatactattg cagtgattaa tgcgcttttc ctgaaggctc ctgatgagag     1080

gaggcaggag atggcgaata ttttggctca gaagcaactg cgttccatca ttttaacaca     1140

tgtcatccga gcccagcggg ccatcaacaa tgagatggcg caccagctgt atgttctaca     1200

agtgctcacc tttaacctcc tggaagacag gatgatgacc aaaatggacc cccaggacca     1260

ggctcagagg gacatcatat ttgaacttcg aagaattgct tttgatgctg agtctgaacc     1320

taacaacagc agtggcagca tggagaaacg caagtccatg tacacgcgag attataagaa     1380

gcttgggttc attaatcatg tcaaccctgc catggacttc acgcagactc cacctgggat     1440

gttggctctg gacaacatgc tgtactttgc caagcaccac caagatgcct acatccggat     1500

tgtgcttgag aacagtagtc gagaagacaa gcatgaatgt ccctttggcc gcagtagtat     1560

agagctgacc aagatgctat gtgagatctt gaaagtgggc gagttgccta gtgagacctg     1620

caacgacttc cacccgatgt tcttcaccca cgacagatcc tttgaggagt ttttctgcat     1680

ctgtatccag ctcctgaaca agacatggaa ggaaatgagg gcaacttctg aagacttcaa     1740

caaggtaatg caggtggtga aggagcaggt tatgagagca cttacaacca agcctagctc     1800

cctggaccag ttcaagagca aactgcagaa cctgagctac actgagatcc tgaaaatccg     1860

ccagtccgag aggatgaacc aggaagattt ccagtcccgc ccgattttgg aactaaagga     1920

gaagattcag ccagaaatct tagagctgat caaacagcaa cgcctgaacc gccttgtgga     1980

agggacctgc tttaggaaac tcaatgcccg gcggaggcaa gacaagtttt ggtattgtcg     2040

gctttcgcca aatcacaaag tcctgcatta cggagactta gaagagagtc ctcagggaga     2100

agtgccccac gattccttgc aggacaaact gccggtggca gatatcaaag ccgtggtgac     2160

gggaaaggac tgccctcata tgaaagagaa aggtgccctt aaacaaaaca aggaggtgct     2220

tgaactcgct ttctccatct tgtatgactc aaactgccaa ctgaacttca tcgctcctga     2280

caagcatgag tactgtatct ggacggatgg actgaatgcg ctactcggga aggacatgat     2340

gagcgacctg acgcggaatg acctggacac cctgctcagc atggaaatca agctccgcct     2400

cctggacctg gaaaacatcc agatccctga cgcacctccg ccgattccca aggagcccag     2460

caactatgac ttcgtctatg actgtaactg aagtggccgg gcccagacat gccccttcca     2520

aaactggaac acctagctaa caggagagag gaatgaaaac acacccacgc cttggaaccg     2580

tcctttggta aagggaagct gtgggtccac attcccttca gcatcacctc tagccctggc     2640

aactttcagc ccctagctgg catcttgctc accgccctga ttctgttcct cggctccact     2700

gcttcaggtc acttcccatg gctgcagtcc actggtggga caagagcaaa gcccactgcc     2760

agtaagaagg ccaaagggcc cttccatcct agccctctgc aggcatgccc ttccttccct     2820

tgggcaggaa agccagcagc cccagactgc ccaaaaactt gcccaccaga ccaagggcag     2880

tgccccaagg cccctgtctg gaggaaatgg cctagctatt tgatgagaag accaaacccc     2940

acatcctcct ttcccctctc tctagaatca tctcgcacca ccagttacac ttgaattaag     3000

atctgcgctc aaatctcctc ccacctctct ccctgctttt gccttgctct gttcctcttt     3060

ggtcccaaga gcagcagccg cagcctcctc gtgatcctcc ctagcataaa tttcccaaac     3120

agtccacagg tcccatgccc actttgcgtc tgcactgtga tcgtgacaaa tcttccctcc     3180

tcaccagcta gtctggggtt tcctctccct gccccaggcc agaactgcct tcttcatttc     3240

cacccacgct cccagcctct tagctgaaag cacaaatggt gaaatcagta gtctcgctcc     3300

atctctaata gactaaacct aaatgcctct aggacggact gttgctatcc aagcgtttgg     3360

tgttaccttc tcctgggagg tcctgctgca actcaagttc cacaggatgg tcaagctgtc     3420

agacatccaa gtttacatca ttgtaattat tactggtatt tacaatttgc aagagttttg     3480

ggttagtttt tttttttttt tttgctttgt ttttgtacaa aagagtctaa cattttttgc     3540

caaacagata tatatttaat gaaaagaaga gatacataaa tgtgtgaatt tccagttttt     3600

ttttaattat tttaatccca aacatcttcc tgaaaataac attcccttaa acatgctgtg     3660

gaataaaatg gattgtgatg atttggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3720

aaaaaaa                                                               3727


<210>  16
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Pro Pro Ala Asp Ile Val Lys Val Ala Ile Glu Trp Pro Gly 
1               5                   10                  15      


Ala Tyr Pro Lys Leu Met Glu Ile Asp Gln Lys Lys Pro Leu Ser Ala 
            20                  25                  30          


Ile Ile Lys Glu Val Cys Asp Gly Trp Ser Leu Ala Asn His Glu Tyr 
        35                  40                  45              


Phe Ala Leu Gln His Ala Asp Ser Ser Asn Phe Tyr Ile Thr Glu Lys 
    50                  55                  60                  


Asn Arg Asn Glu Ile Lys Asn Gly Thr Ile Leu Arg Leu Thr Thr Ser 
65                  70                  75                  80  


Pro Ala Gln Asn Ala Gln Gln Leu His Glu Arg Ile Gln Ser Ser Ser 
                85                  90                  95      


Met Asp Ala Lys Leu Glu Ala Leu Lys Asp Leu Ala Ser Leu Ser Arg 
            100                 105                 110         


Asp Val Thr Phe Ala Gln Glu Phe Ile Asn Leu Asp Gly Ile Ser Leu 
        115                 120                 125             


Leu Thr Gln Met Val Glu Ser Gly Thr Glu Arg Tyr Gln Lys Leu Gln 
    130                 135                 140                 


Lys Ile Met Lys Pro Cys Phe Gly Asp Met Leu Ser Phe Thr Leu Thr 
145                 150                 155                 160 


Ala Phe Val Glu Leu Met Asp His Gly Ile Val Ser Trp Asp Thr Phe 
                165                 170                 175     


Ser Val Ala Phe Ile Lys Lys Ile Ala Ser Phe Val Asn Lys Ser Ala 
            180                 185                 190         


Ile Asp Ile Ser Ile Leu Gln Arg Ser Leu Ala Ile Leu Glu Ser Met 
        195                 200                 205             


Val Leu Asn Ser His Asp Leu Tyr Gln Lys Val Ala Gln Glu Ile Thr 
    210                 215                 220                 


Ile Gly Gln Leu Ile Pro His Leu Gln Gly Ser Asp Gln Glu Ile Gln 
225                 230                 235                 240 


Thr Tyr Thr Ile Ala Val Ile Asn Ala Leu Phe Leu Lys Ala Pro Asp 
                245                 250                 255     


Glu Arg Arg Gln Glu Met Ala Asn Ile Leu Ala Gln Lys Gln Leu Arg 
            260                 265                 270         


Ser Ile Ile Leu Thr His Val Ile Arg Ala Gln Arg Ala Ile Asn Asn 
        275                 280                 285             


Glu Met Ala His Gln Leu Tyr Val Leu Gln Val Leu Thr Phe Asn Leu 
    290                 295                 300                 


Leu Glu Asp Arg Met Met Thr Lys Met Asp Pro Gln Asp Gln Ala Gln 
305                 310                 315                 320 


Arg Asp Ile Ile Phe Glu Leu Arg Arg Ile Ala Phe Asp Ala Glu Ser 
                325                 330                 335     


Glu Pro Asn Asn Ser Ser Gly Ser Met Glu Lys Arg Lys Ser Met Tyr 
            340                 345                 350         


Thr Arg Asp Tyr Lys Lys Leu Gly Phe Ile Asn His Val Asn Pro Ala 
        355                 360                 365             


Met Asp Phe Thr Gln Thr Pro Pro Gly Met Leu Ala Leu Asp Asn Met 
    370                 375                 380                 


Leu Tyr Phe Ala Lys His His Gln Asp Ala Tyr Ile Arg Ile Val Leu 
385                 390                 395                 400 


Glu Asn Ser Ser Arg Glu Asp Lys His Glu Cys Pro Phe Gly Arg Ser 
                405                 410                 415     


Ser Ile Glu Leu Thr Lys Met Leu Cys Glu Ile Leu Lys Val Gly Glu 
            420                 425                 430         


Leu Pro Ser Glu Thr Cys Asn Asp Phe His Pro Met Phe Phe Thr His 
        435                 440                 445             


Asp Arg Ser Phe Glu Glu Phe Phe Cys Ile Cys Ile Gln Leu Leu Asn 
    450                 455                 460                 


Lys Thr Trp Lys Glu Met Arg Ala Thr Ser Glu Asp Phe Asn Lys Val 
465                 470                 475                 480 


Met Gln Val Val Lys Glu Gln Val Met Arg Ala Leu Thr Thr Lys Pro 
                485                 490                 495     


Ser Ser Leu Asp Gln Phe Lys Ser Lys Leu Gln Asn Leu Ser Tyr Thr 
            500                 505                 510         


Glu Ile Leu Lys Ile Arg Gln Ser Glu Arg Met Asn Gln Glu Asp Phe 
        515                 520                 525             


Gln Ser Arg Pro Ile Leu Glu Leu Lys Glu Lys Ile Gln Pro Glu Ile 
    530                 535                 540                 


Leu Glu Leu Ile Lys Gln Gln Arg Leu Asn Arg Leu Val Glu Gly Thr 
545                 550                 555                 560 


Cys Phe Arg Lys Leu Asn Ala Arg Arg Arg Gln Asp Lys Phe Trp Tyr 
                565                 570                 575     


Cys Arg Leu Ser Pro Asn His Lys Val Leu His Tyr Gly Asp Leu Glu 
            580                 585                 590         


Glu Ser Pro Gln Gly Glu Val Pro His Asp Ser Leu Gln Asp Lys Leu 
        595                 600                 605             


Pro Val Ala Asp Ile Lys Ala Val Val Thr Gly Lys Asp Cys Pro His 
    610                 615                 620                 


Met Lys Glu Lys Gly Ala Leu Lys Gln Asn Lys Glu Val Leu Glu Leu 
625                 630                 635                 640 


Ala Phe Ser Ile Leu Tyr Asp Ser Asn Cys Gln Leu Asn Phe Ile Ala 
                645                 650                 655     


Pro Asp Lys His Glu Tyr Cys Ile Trp Thr Asp Gly Leu Asn Ala Leu 
            660                 665                 670         


Leu Gly Lys Asp Met Met Ser Asp Leu Thr Arg Asn Asp Leu Asp Thr 
        675                 680                 685             


Leu Leu Ser Met Glu Ile Lys Leu Arg Leu Leu Asp Leu Glu Asn Ile 
    690                 695                 700                 


Gln Ile Pro Asp Ala Pro Pro Pro Ile Pro Lys Glu Pro Ser Asn Tyr 
705                 710                 715                 720 


Asp Phe Val Tyr Asp Cys Asn 
                725         


<210>  17
<211>  2129
<212>  DNA
<213>  Homo sapiens

<400>  17
tggaggggca gcgtggggaa cgagaaactc tttgcctgta gggacccttc tagctgcaaa       60

cttaaaaatg tatgtggcaa gatgcaaccc aagcaccgag caggattcca gacgagttat      120

aatcattctg aacggggaga ggaaaggtaa tgcaggtggt gaaggagcag gttatgagag      180

cacttacaac caagcctagc tccctggacc agttcaagag caaactgcag aacctgagct      240

acactgagat cctgaaaatc cgccagtccg agaggatgaa ccaggaagat ttccagtccc      300

gcccgatttt ggaactaaag gagaagattc agccagaaat cttagagctg atcaaacagc      360

aacgcctgaa ccgccttgtg gaagggacct gctttaggaa actcaatgcc cggcggaggc      420

aagacaagtt ttggtattgt cggctttcgc caaatcacaa agtcctgcat tacggagact      480

tagaagagag tcctcaggga gaagtgcccc acgattcctt gcaggacaaa ctgccggtgg      540

cagatatcaa agccgtggtg acgggaaagg actgccctca tatgaaagag aaaggtgccc      600

ttaaacaaaa caaggaggtg cttgaactcg ctttctccat cttgtatgac tcaaactgcc      660

aactgaactt catcgctcct gacaagcatg agtactgtat ctggacggat ggactgaatg      720

cgctactcgg gaaggacatg atgagcgacc tgacgcggaa tgacctggac accctgctca      780

gcatggaaat caagctccgc ctcctggacc tggaaaacat ccagatccct gacgcacctc      840

cgccgattcc caaggagccc agcaactatg acttcgtcta tgactgtaac tgaagtggcc      900

gggcccagac atgccccttc caaaactgga acacctagct aacaggagag aggaatgaaa      960

acacacccac gccttggaac cgtcctttgg taaagggaag ctgtgggtcc acattccctt     1020

cagcatcacc tctagccctg gcaactttca gcccctagct ggcatcttgc tcaccgccct     1080

gattctgttc ctcggctcca ctgcttcagg tcacttccca tggctgcagt ccactggtgg     1140

gacaagagca aagcccactg ccagtaagaa ggccaaaggg cccttccatc ctagccctct     1200

gcaggcatgc ccttccttcc cttgggcagg aaagccagca gccccagact gcccaaaaac     1260

ttgcccacca gaccaagggc agtgccccaa ggcccctgtc tggaggaaat ggcctagcta     1320

tttgatgaga agaccaaacc ccacatcctc ctttcccctc tctctagaat catctcgcac     1380

caccagttac acttgaatta agatctgcgc tcaaatctcc tcccacctct ctccctgctt     1440

ttgccttgct ctgttcctct ttggtcccaa gagcagcagc cgcagcctcc tcgtgatcct     1500

ccctagcata aatttcccaa acagtccaca ggtcccatgc ccactttgcg tctgcactgt     1560

gatcgtgaca aatcttccct cctcaccagc tagtctgggg tttcctctcc ctgccccagg     1620

ccagaactgc cttcttcatt tccacccacg ctcccagcct cttagctgaa agcacaaatg     1680

gtgaaatcag tagtctcgct ccatctctaa tagactaaac ctaaatgcct ctaggacgga     1740

ctgttgctat ccaagcgttt ggtgttacct tctcctggga ggtcctgctg caactcaagt     1800

tccacaggat ggtcaagctg tcagacatcc aagtttacat cattgtaatt attactggta     1860

tttacaattt gcaagagttt tgggttagtt tttttttttt tttttgcttt gtttttgtac     1920

aaaagagtct aacatttttt gccaaacaga tatatattta atgaaaagaa gagatacata     1980

aatgtgtgaa tttccagttt ttttttaatt attttaatcc caaacatctt cctgaaaata     2040

acattccctt aaacatgctg tggaataaaa tggattgtga tgatttggaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       2129


<210>  18
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gln Val Val Lys Glu Gln Val Met Arg Ala Leu Thr Thr Lys Pro 
1               5                   10                  15      


Ser Ser Leu Asp Gln Phe Lys Ser Lys Leu Gln Asn Leu Ser Tyr Thr 
            20                  25                  30          


Glu Ile Leu Lys Ile Arg Gln Ser Glu Arg Met Asn Gln Glu Asp Phe 
        35                  40                  45              


Gln Ser Arg Pro Ile Leu Glu Leu Lys Glu Lys Ile Gln Pro Glu Ile 
    50                  55                  60                  


Leu Glu Leu Ile Lys Gln Gln Arg Leu Asn Arg Leu Val Glu Gly Thr 
65                  70                  75                  80  


Cys Phe Arg Lys Leu Asn Ala Arg Arg Arg Gln Asp Lys Phe Trp Tyr 
                85                  90                  95      


Cys Arg Leu Ser Pro Asn His Lys Val Leu His Tyr Gly Asp Leu Glu 
            100                 105                 110         


Glu Ser Pro Gln Gly Glu Val Pro His Asp Ser Leu Gln Asp Lys Leu 
        115                 120                 125             


Pro Val Ala Asp Ile Lys Ala Val Val Thr Gly Lys Asp Cys Pro His 
    130                 135                 140                 


Met Lys Glu Lys Gly Ala Leu Lys Gln Asn Lys Glu Val Leu Glu Leu 
145                 150                 155                 160 


Ala Phe Ser Ile Leu Tyr Asp Ser Asn Cys Gln Leu Asn Phe Ile Ala 
                165                 170                 175     


Pro Asp Lys His Glu Tyr Cys Ile Trp Thr Asp Gly Leu Asn Ala Leu 
            180                 185                 190         


Leu Gly Lys Asp Met Met Ser Asp Leu Thr Arg Asn Asp Leu Asp Thr 
        195                 200                 205             


Leu Leu Ser Met Glu Ile Lys Leu Arg Leu Leu Asp Leu Glu Asn Ile 
    210                 215                 220                 


Gln Ile Pro Asp Ala Pro Pro Pro Ile Pro Lys Glu Pro Ser Asn Tyr 
225                 230                 235                 240 


Asp Phe Val Tyr Asp Cys Asn 
                245         


<210>  19
<211>  2177
<212>  DNA
<213>  Homo sapiens

<400>  19
catttaaagg tgtgcggcgg gtctctgttc acatggctca actggaaacc tgtttcatga       60

acaagcttac tcaggaacca tctggtggta ttccagcaca ttgttcttca gggggacgac      120

tctaagtcgc tttgtggtgg cagcagctta gaatcagtat ttgtggttgg gaaagatgga      180

cttacgggag cttggtaatg caggtggtga aggagcaggt tatgagagca cttacaacca      240

agcctagctc cctggaccag ttcaagagca aactgcagaa cctgagctac actgagatcc      300

tgaaaatccg ccagtccgag aggatgaacc aggaagattt ccagtcccgc ccgattttgg      360

aactaaagga gaagattcag ccagaaatct tagagctgat caaacagcaa cgcctgaacc      420

gccttgtgga agggacctgc tttaggaaac tcaatgcccg gcggaggcaa gacaagtttt      480

ggtattgtcg gctttcgcca aatcacaaag tcctgcatta cggagactta gaagagagtc      540

ctcagggaga agtgccccac gattccttgc aggacaaact gccggtggca gatatcaaag      600

ccgtggtgac gggaaaggac tgccctcata tgaaagagaa aggtgccctt aaacaaaaca      660

aggaggtgct tgaactcgct ttctccatct tgtatgactc aaactgccaa ctgaacttca      720

tcgctcctga caagcatgag tactgtatct ggacggatgg actgaatgcg ctactcggga      780

aggacatgat gagcgacctg acgcggaatg acctggacac cctgctcagc atggaaatca      840

agctccgcct cctggacctg gaaaacatcc agatccctga cgcacctccg ccgattccca      900

aggagcccag caactatgac ttcgtctatg actgtaactg aagtggccgg gcccagacat      960

gccccttcca aaactggaac acctagctaa caggagagag gaatgaaaac acacccacgc     1020

cttggaaccg tcctttggta aagggaagct gtgggtccac attcccttca gcatcacctc     1080

tagccctggc aactttcagc ccctagctgg catcttgctc accgccctga ttctgttcct     1140

cggctccact gcttcaggtc acttcccatg gctgcagtcc actggtggga caagagcaaa     1200

gcccactgcc agtaagaagg ccaaagggcc cttccatcct agccctctgc aggcatgccc     1260

ttccttccct tgggcaggaa agccagcagc cccagactgc ccaaaaactt gcccaccaga     1320

ccaagggcag tgccccaagg cccctgtctg gaggaaatgg cctagctatt tgatgagaag     1380

accaaacccc acatcctcct ttcccctctc tctagaatca tctcgcacca ccagttacac     1440

ttgaattaag atctgcgctc aaatctcctc ccacctctct ccctgctttt gccttgctct     1500

gttcctcttt ggtcccaaga gcagcagccg cagcctcctc gtgatcctcc ctagcataaa     1560

tttcccaaac agtccacagg tcccatgccc actttgcgtc tgcactgtga tcgtgacaaa     1620

tcttccctcc tcaccagcta gtctggggtt tcctctccct gccccaggcc agaactgcct     1680

tcttcatttc cacccacgct cccagcctct tagctgaaag cacaaatggt gaaatcagta     1740

gtctcgctcc atctctaata gactaaacct aaatgcctct aggacggact gttgctatcc     1800

aagcgtttgg tgttaccttc tcctgggagg tcctgctgca actcaagttc cacaggatgg     1860

tcaagctgtc agacatccaa gtttacatca ttgtaattat tactggtatt tacaatttgc     1920

aagagttttg ggttagtttt tttttttttt tttgctttgt ttttgtacaa aagagtctaa     1980

cattttttgc caaacagata tatatttaat gaaaagaaga gatacataaa tgtgtgaatt     2040

tccagttttt ttttaattat tttaatccca aacatcttcc tgaaaataac attcccttaa     2100

acatgctgtg gaataaaatg gattgtgatg atttggaaaa aaaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaa                                                    2177


<210>  20
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gln Val Val Lys Glu Gln Val Met Arg Ala Leu Thr Thr Lys Pro 
1               5                   10                  15      


Ser Ser Leu Asp Gln Phe Lys Ser Lys Leu Gln Asn Leu Ser Tyr Thr 
            20                  25                  30          


Glu Ile Leu Lys Ile Arg Gln Ser Glu Arg Met Asn Gln Glu Asp Phe 
        35                  40                  45              


Gln Ser Arg Pro Ile Leu Glu Leu Lys Glu Lys Ile Gln Pro Glu Ile 
    50                  55                  60                  


Leu Glu Leu Ile Lys Gln Gln Arg Leu Asn Arg Leu Val Glu Gly Thr 
65                  70                  75                  80  


Cys Phe Arg Lys Leu Asn Ala Arg Arg Arg Gln Asp Lys Phe Trp Tyr 
                85                  90                  95      


Cys Arg Leu Ser Pro Asn His Lys Val Leu His Tyr Gly Asp Leu Glu 
            100                 105                 110         


Glu Ser Pro Gln Gly Glu Val Pro His Asp Ser Leu Gln Asp Lys Leu 
        115                 120                 125             


Pro Val Ala Asp Ile Lys Ala Val Val Thr Gly Lys Asp Cys Pro His 
    130                 135                 140                 


Met Lys Glu Lys Gly Ala Leu Lys Gln Asn Lys Glu Val Leu Glu Leu 
145                 150                 155                 160 


Ala Phe Ser Ile Leu Tyr Asp Ser Asn Cys Gln Leu Asn Phe Ile Ala 
                165                 170                 175     


Pro Asp Lys His Glu Tyr Cys Ile Trp Thr Asp Gly Leu Asn Ala Leu 
            180                 185                 190         


Leu Gly Lys Asp Met Met Ser Asp Leu Thr Arg Asn Asp Leu Asp Thr 
        195                 200                 205             


Leu Leu Ser Met Glu Ile Lys Leu Arg Leu Leu Asp Leu Glu Asn Ile 
    210                 215                 220                 


Gln Ile Pro Asp Ala Pro Pro Pro Ile Pro Lys Glu Pro Ser Asn Tyr 
225                 230                 235                 240 


Asp Phe Val Tyr Asp Cys Asn 
                245         


<210>  21
<211>  3936
<212>  DNA
<213>  Homo sapiens

<400>  21
aaattctgca agtgaacttg actcaggaag gccagcggct caaggtccag cccctggaag       60

agagaatagc tacagattct ccatcctcag tctttgcaag gcgacagctg tgccagccgg      120

gctctggcag gctcctggca gcatggcagt gaagcttggg accctcctgc tggcccttgc      180

cctgggcctg gcccagccag cctctgcccg ccggaagctg ctggtgtttc tgctggatgg      240

ttttcgctca gactacatca gtgatgaggc gctggagtca ttgcctggtt tcaaagagat      300

tgtgagcagg ggagtaaaag tggattactt gactccagac ttccctagtc tctcgtatcc      360

caattattat accctaatga ctggccgcca ttgtgaagtc catcagatga tcgggaacta      420

catgtgggac cccaccacca acaagtcctt tgacattggc gtcaacaaag acagcctaat      480

gcctctctgg tggaatggat cagaacctct gtgggtcact ctgaccaagg ccaaaaggaa      540

ggtctacatg tactactggc caggctgtga ggttgagatt ctgggtgtca gacccaccta      600

ctgcctagaa tataaaaatg tcccaacgga tatcaatttt gccaatgcag tcagcgatgc      660

tcttgactcc ttcaagagtg gccgggccga cctggcagcc atataccatg agcgcattga      720

cgtggaaggc caccactacg ggcctgcatc tccgcagagg aaagatgccc tcaaggctgt      780

agacactgtc ctgaagtaca tgaccaagtg gatccaggag cggggcctgc aggaccgcct      840

gaacgtcatt attttctcgg atcacggaat gaccgacatt ttctggatgg acaaagtgat      900

tgagctgaat aagtacatca gcctgaatga cctgcagcaa gtgaaggacc gcgggcctgt      960

tgtgagcctt tggccggccc ctgggaaaca ctctgagata tataacaaac tgagcacagt     1020

ggaacacatg actgtctacg agaaagaagc catcccaagc aggttctatt acaagaaagg     1080

aaagtttgtc tctcctttga ctttagtggc tgatgaaggc tggttcataa ctgagaatcg     1140

agagatgctt ccgttttgga tgaacagcac cggcaggcgg gaaggttggc agcgtggatg     1200

gcacggctac gacaacgagc tcatggacat gcggggcatc ttcctggcct tcggacctga     1260

tttcaaatcc aacttcagag ctgctcctat caggtcggtg gacgtctaca atgtcatgtg     1320

caatgtggtg ggcatcaccc cgctgcccaa caacggatcc tggtccaggg tgatgtgcat     1380

gctgaagggc cgcgccagca ctgccccgcc tgtctggccc agccactgtg ccctggcact     1440

gattcttctc ttcctgcttg cataactgat catattgctt gtctcagaaa aaaacaccat     1500

cagcaaagtg ggcctccaaa gccagatgat tttcatttta tgtgtgaata atagcttcat     1560

taacacaatc aagaccatgc acattgtaaa tacattattc ttggataatt ctatacataa     1620

aagttcctac ttgttaaaaa agatacaaac cttgtttttc cagaaggtag gaaaatccta     1680

gctttccatt tgtgcagtta tatgtcattt tctcctttct tttcacgtta ctcaggatga     1740

actctctgag cagggacctg ctcctgcagc aaccaaactt ggagtggtta ttgcagacag     1800

acgtggctct gggcccctct ctgtcccacc ttgcacaaag gaccccctca gaccaggccc     1860

ttgtctgtgc cctgtccaca cccaggagcc atcctcagtg tctgtggcca caatcctgta     1920

ctgttccttc catccctgat aaaaggaggt ctacatgaaa gcaaaagcta ctgtctattt     1980

ctgacccagc tcatggaatt ttttcatctt atactgagct ccagaaagga cgtaacttag     2040

catggatcac caatcaatca aaaaataaat aaatcactaa ggattggaga actcatagaa     2100

caaggtgaaa gacatgagtg ccctcccaaa gtctgagtgc acgaaaattt ctctcttgcc     2160

ttgaggagca gaaaagcttc tgatggacat gggcttctgt gagacttatc acacatagtg     2220

tatcgtggca tgaagcccgg cacatagcag gccctgcata ttgatggaca aatggatggc     2280

ctgcctgcct tccctgtccg ttcacctgtg caaaggcttc ctcagacatg ccactctgtg     2340

gctcccaata tagggtgcag acaagagcaa tccctgacat gacattatag cctgggaaag     2400

ggctggctca ctgatgagaa tgtggaggca tcagcaagga tctcggtggg ttgctcagag     2460

aggtgatgca ctaagcctta atcctggaca ccagtacccc tgcagcatgg cttgctcaac     2520

aacagtcttt gagtggcata gaattccaaa gaaaatggtg ctgggtggag aatggagaga     2580

gcatgatgga gcagagtccc agtcactgac caactaactg gtcgtttgat taggaaacag     2640

tttggccaaa gtaccacctt tgagacctaa gttcttttga tacctttgag aagagccact     2700

gagcctgagt tgaaatattt ttagcttagt catctgtgtt tgctatagga gaaattgtaa     2760

cacaagaaat aactcctttt tacatgatca tttatatcta tatacatata tatacttgca     2820

tacactatca ctgcattaaa aaatgagttt gggctgggca tggtggctca cacctataat     2880

cccaacactt tcggaggcca aggagggaca aacgaaccct tgaggccagg agttccagac     2940

taacttgggc aacacagggc gacccccatc tctacaaaac ataaaagatt tttaaaaaat     3000

tagccaggca tggtggcaca tgcctgtggt ctcagctact tgggaggctg aggcaggaga     3060

atcatttgag cccaggaggt caaggctgca gtgagctttg atcacaccac tgcactccag     3120

cctgggcaac agagcaagac cccatcctcc acccccccca aaaaatagaa agaaaaaaaa     3180

agtttgcact aattgaggta catctgcaag tgagactttt tgtcaggaaa aggcaatata     3240

tcaggtctcc tcaggacgat ggaggcctta tatggtgtgt taccttgaaa actgaatatc     3300

aacgttcacc ttgattcagg aaagctgggt gctgtctcca tgccatgaat catgagagca     3360

aaggatcact gcttaaaaat actgaattta ccttcacaaa agatttctaa agatttatgt     3420

aatgtgtttt aaaagcgcca gtaaaccatc ggatcaattg gaaagaaggc aactcttcag     3480

cctttgttat ctagctgaaa acaaatgaca actttcaaaa cattggcagt agttgttgaa     3540

aaagacgtct attgttcaaa gtttctttct ccttaaagga cggtgttcca atgaattcag     3600

tagagcccac tttcctccac tgtggaggaa gaatccctaa gagatactca aatgattaaa     3660

ttaaaattgg atcatcaaac tcaagagagg cataaactta gacacagtct tgcatttttg     3720

tctttcctga actcttctgc cattttcctc cttcactcgt cctgaaaatc tgcaagttac     3780

ataataaaac tttagatatt tgtctgacaa agtgtaatta ctcaactgaa taaatgactg     3840

agaacaagtt acaaaaggaa tcatgaatcc tggtaaacaa taaagaagat tcagacactg     3900

agggaaaaaa ataaagcttt ttacttaaat aatgca                               3936


<210>  22
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Val Lys Leu Gly Thr Leu Leu Leu Ala Leu Ala Leu Gly Leu 
1               5                   10                  15      


Ala Gln Pro Ala Ser Ala Arg Arg Lys Leu Leu Val Phe Leu Leu Asp 
            20                  25                  30          


Gly Phe Arg Ser Asp Tyr Ile Ser Asp Glu Ala Leu Glu Ser Leu Pro 
        35                  40                  45              


Gly Phe Lys Glu Ile Val Ser Arg Gly Val Lys Val Asp Tyr Leu Thr 
    50                  55                  60                  


Pro Asp Phe Pro Ser Leu Ser Tyr Pro Asn Tyr Tyr Thr Leu Met Thr 
65                  70                  75                  80  


Gly Arg His Cys Glu Val His Gln Met Ile Gly Asn Tyr Met Trp Asp 
                85                  90                  95      


Pro Thr Thr Asn Lys Ser Phe Asp Ile Gly Val Asn Lys Asp Ser Leu 
            100                 105                 110         


Met Pro Leu Trp Trp Asn Gly Ser Glu Pro Leu Trp Val Thr Leu Thr 
        115                 120                 125             


Lys Ala Lys Arg Lys Val Tyr Met Tyr Tyr Trp Pro Gly Cys Glu Val 
    130                 135                 140                 


Glu Ile Leu Gly Val Arg Pro Thr Tyr Cys Leu Glu Tyr Lys Asn Val 
145                 150                 155                 160 


Pro Thr Asp Ile Asn Phe Ala Asn Ala Val Ser Asp Ala Leu Asp Ser 
                165                 170                 175     


Phe Lys Ser Gly Arg Ala Asp Leu Ala Ala Ile Tyr His Glu Arg Ile 
            180                 185                 190         


Asp Val Glu Gly His His Tyr Gly Pro Ala Ser Pro Gln Arg Lys Asp 
        195                 200                 205             


Ala Leu Lys Ala Val Asp Thr Val Leu Lys Tyr Met Thr Lys Trp Ile 
    210                 215                 220                 


Gln Glu Arg Gly Leu Gln Asp Arg Leu Asn Val Ile Ile Phe Ser Asp 
225                 230                 235                 240 


His Gly Met Thr Asp Ile Phe Trp Met Asp Lys Val Ile Glu Leu Asn 
                245                 250                 255     


Lys Tyr Ile Ser Leu Asn Asp Leu Gln Gln Val Lys Asp Arg Gly Pro 
            260                 265                 270         


Val Val Ser Leu Trp Pro Ala Pro Gly Lys His Ser Glu Ile Tyr Asn 
        275                 280                 285             


Lys Leu Ser Thr Val Glu His Met Thr Val Tyr Glu Lys Glu Ala Ile 
    290                 295                 300                 


Pro Ser Arg Phe Tyr Tyr Lys Lys Gly Lys Phe Val Ser Pro Leu Thr 
305                 310                 315                 320 


Leu Val Ala Asp Glu Gly Trp Phe Ile Thr Glu Asn Arg Glu Met Leu 
                325                 330                 335     


Pro Phe Trp Met Asn Ser Thr Gly Arg Arg Glu Gly Trp Gln Arg Gly 
            340                 345                 350         


Trp His Gly Tyr Asp Asn Glu Leu Met Asp Met Arg Gly Ile Phe Leu 
        355                 360                 365             


Ala Phe Gly Pro Asp Phe Lys Ser Asn Phe Arg Ala Ala Pro Ile Arg 
    370                 375                 380                 


Ser Val Asp Val Tyr Asn Val Met Cys Asn Val Val Gly Ile Thr Pro 
385                 390                 395                 400 


Leu Pro Asn Asn Gly Ser Trp Ser Arg Val Met Cys Met Leu Lys Gly 
                405                 410                 415     


Arg Ala Ser Thr Ala Pro Pro Val Trp Pro Ser His Cys Ala Leu Ala 
            420                 425                 430         


Leu Ile Leu Leu Phe Leu Leu Ala 
        435                 440 


<210>  23
<211>  5084
<212>  DNA
<213>  Homo sapiens

<400>  23
gggcgggggc gatgctgccg gagccgccgc cgccgccgcc gcctcgatga gagccgcgcc       60

gcaccgctca tagccgcaca ggctgacagg caggaggacc gacttccctc tcccgggcat      120

cctccctggg ctgccgggag gcggcggcgg cggaggagga ggaggaacga ggggagaagg      180

cggagagcag gaacgcgagg aggaggacct ggatccgttt cctccggcca ggacccgagc      240

ggccccagcc accgctaccc gccggcgctg tccgctctcc atcagccctc ctgcgcccac      300

ccgcgacccc gggctctctg cgcgtcgggc cggggccgga gccgcgcgcc ggagactatc      360

tggcttcctg gtgatgctca cgctttgcta agtgttggcg gccatcgtgg ttttcgcatc      420

ctggggacga atcctgagct tgccagagac gggcggcgca aggtccgggc tctgtttccc      480

tgtgagaagc cgcctcggcc caccgagatg tcccggcacc atagccgctt cgaaagagat      540

taccgggtgg gctgggaccg ccgcgaatgg agcgtcaacg ggacgcatgg gaccaccagc      600

atctgcagtg tcacctcggg ggccggtggc ggcacagcca gcagcctcag cgtccggccc      660

ggcctcctgc cgctgcccgt ggtgccctcc cggctgccca ccccggctac agctcctgct      720

ccctgcacca ccggcagcag cgaggccatc accagcctcg tggccagctc tgcgtctgcg      780

gtcaccacca aggctcccgg catctccaaa ggggacagtc agtcccaggg actggcgacc      840

agcatccggt gggggcagac gcctatcaat cagtccacac cctgggacac tgatgagcca      900

ccctccaaac agatgagaga gagtgacaat ccaggcacag ggccatgggt gaccacggtg      960

gccgccggga accagcccac cctgattgca cactcctatg gagtggccca gcctcccacc     1020

ttcagcccgg ctgtgaacgt ccaggccccg gtcattgggg tgaccccctc actgcctccc     1080

cacgtggggc cccagctccc gctgatgcca ggccactact cgctccctca gccgccctct     1140

cagccactga gcagcgtggt ggtcaacatg cctgcccagg ccctgtatgc cagccctcag     1200

cccctggccg tgtccacact gcccggtgtg gggcaggtgg cccgcccagg acccaccgct     1260

gtgggcaacg gccacatggc agggcccctg ctgcctccac cgccgccagc ccagccgtcc     1320

gccactctcc ccagtggtgc ccctgccacc aatgggcccc ccacaaccga ctcggcccac     1380

gggctgcaga tgctgcggac cattggcgtg gggaagtatg agttcaccga cccggggcac     1440

cccagagaaa tgttgaagga attgaaccag caacgcagag cgaaagcgtt tacagacctg     1500

aaaattgttg ttgaaggcag agagtttgaa gtccaccaaa atgttctagc ttcctgcagc     1560

ttgtatttca aggacctgat tcaaaggtcc gtgcaagaca gcggccaggg cggccgggag     1620

aagctggagc tcgtcctgtc gaacctgcag gcagacgtcc tggagttgct gctggagttt     1680

gtctacacgg gctccctggt catcgactcg gccaacgcca agacactgct ggaggcggcc     1740

agcaagttcc agttccacac cttctgcaaa gtctgcgtgt cctttctcga gaagcagctg     1800

acggccagca actgcctggg cgtgctggcc atggccgagg ccatgcagtg cagcgagctc     1860

taccacatgg ccaaggcctt cgcgctgcag atcttccccg aggtggccgc ccaggaggag     1920

atcctcagca tctccaagga cgacttcatc gcctacgtct ccaacgacag cctcaacacc     1980

aaggctgagg agctggtgta cgagacagtc atcaagtgga tcaagaagga ccccgcgaca     2040

cgcacacagt acgcggctga gctcctggcc gtggtccgcc tccccttcat ccaccccagc     2100

tacctgctca atgtggttga caatgaagag ctgatcaagt catcagaagc ctgccgggac     2160

ctggtgaacg aggccaaacg ctaccatatg ctgccccacg cccgccagga gatgcagacg     2220

ccccgaaccc ggccgcgcct ctctgcaggt gtggctgagg tcatcgtctt ggttgggggc     2280

cgtcagatgg tggggatgac ccagcgctcg ctggtggccg tcacctgctg gaacccgcag     2340

aacaacaagt ggtacccctt ggcctcgctg cccttctatg accgcgagtt cttcagtgta     2400

gtgagtgcag gggacaacat ctacctctca ggtgggatgg aatcaggggt gacgctggct     2460

gatgtctggt gctacatgtc cctgcttgat aactggaacc tcgtctccag aatgacagtc     2520

ccccgctgtc ggcacaatag cctcgtctac gatgggaaga tttacaccct cgggggactt     2580

ggcgtggcag gcaacgtgga ccacgtggag aggtacgaca ccatcaccaa ccaatgggag     2640

gcggtggccc ctctgcccaa ggcagtacac tctgctgcag ccacagtgtg tggcggcaag     2700

atctacgtgt ttggtggggt gaacgaggca ggccgagctg ccggcgtcct ccagtcttac     2760

gttcctcaga ccaacacgtg gagcttcatc gagtccccaa tgattgacaa caagtatgcc     2820

cccgctgtca cgctcaatgg cttcgttttc atcctgggcg gggcttatgc cagagctacc     2880

accatctacg accctgagaa aggaaacatt aaggcgggcc caaacatgaa ccactctcgc     2940

cagttctgca gtgctgtggt gcttgatggc aagatttatg caactggagg tattgtcagc     3000

agtgaagggc ccgcgctggg caacatggag gcctacgagc ccacaaccaa cacatggacc     3060

ctcctccccc acatgccctg ccctgtgttc agacacggct gcgtcgtgat aaagaaatat     3120

attcaaagcg gctgacatca gcagaaagcc cacgataaga ctgtggacaa gtctggtgag     3180

gcaagtgcca cgcaatgata attttccagc gacaccaaca agaggccaac aaaacacaat     3240

caaggaactc actgcgctca acatgttgaa tattctctac attgaatgta gaaaatcatc     3300

ctcgcctttg gatgaaacgg aggcaccgcg cttggagccg caggaaccac gatcccgcca     3360

tggggctggc tgcctcctga acaggggcgc tcgctctgcc aggtgcaata gagtttcacg     3420

tatttttcaa ctgggagaga gaagctgttt tttccttcct gcagagcaag cttgatccct     3480

aaacaaccat agatcagtta tcttatgaca acattaggca tcaggctctc ttggaataag     3540

atcaaagtgt ccttatcact ttgattccta cttttgtttt ttaaccgatc tacactttca     3600

gtggccgaca gaaaacgagg gacaatactg tgcatcacaa ggcctaggag gctgctggtc     3660

cccactgggg ctgaagagaa gcccagctgc ccacgcggag ccaggggtgg cagctgtggg     3720

acagccgggg agcagggaca gcggtctgtc cttcacaggt ttttctactg tgtttttgct     3780

ggagaaggac agtgattgcg ctagctttct cttacccggt atgaattatt tagatttctg     3840

aggcattttc ttgataaaca aaaggctatt tttaagtact gagaggagga gcaggccaca     3900

agagggataa tgttgtggga attcccaaag ctctttgtag gtagtgccag aggggggctt     3960

ttgctctcat ttttctatgt gcagaataga ggatctctcc tggggtgggc gatgccccca     4020

ttttattttt agaaaaagta actcccagac agccccataa aagctgtgcc caaggaagaa     4080

gagtctgctc tagaaggagc ccggttctgg ctcaggacac cggcccagct ccctccatga     4140

ggtcaagctg aggaccaggc cagtgggaag ggaaggaggg agaattagcg tctataaagc     4200

acaggagact atttttgata ttcatagcta tatattaagg cacctgccac aagagctctc     4260

aggatgggga cagccttctt agtggagcca tggcagcaag gcctgagggc atgaacagaa     4320

ccactcttct tgtcacatac gaacctgaga aaagggaagc caggagggag gtcacaccat     4380

ggctcaaaag ggaaaggcct tcccacttgt ccttagcccc tcaaacctca cacggtcaac     4440

agtttccatt ccagggcagg agaatgctgc cgccactgcg ctgttgagtt gaagttggta     4500

ccaaatacac atttaccact tttatatctg ggaagtcaac ttgccatcgt ttcatgataa     4560

caaccattta taagagaaaa agacaggaca cgctttccat cgttcagtat ttgatgacac     4620

aaaattccag ttctaacgtt gggcatcaac ttctagcact acgagtgtgg ctcccacttg     4680

gacaagatac cgagcttcgt tatgcagttt ttaatattat ttattatttt aaaaagtaat     4740

aagcacaaaa ctacatacat tgtatgtcat ttaaagtatt tatgtcaaac agggtgcaag     4800

tgtgaaccca aggactggag cacaaattcc taactgcctg gggcagggct aatgttagca     4860

ttggtgtgcg tctgcctcca aaggaggttc tagttgtcag cgagactcaa cacagatgac     4920

attgaaattc gtttctctcc tcatctatca cactggagca aaactggcta tttctgtgaa     4980

tgatataaaa cagggttctc tgtaatggta ttgtacatag tatatgttta ctgttaagtt     5040

cttgttatat tataataaat atatttatag atctagactt ggaa                      5084


<210>  24
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Arg His His Ser Arg Phe Glu Arg Asp Tyr Arg Val Gly Trp 
1               5                   10                  15      


Asp Arg Arg Glu Trp Ser Val Asn Gly Thr His Gly Thr Thr Ser Ile 
            20                  25                  30          


Cys Ser Val Thr Ser Gly Ala Gly Gly Gly Thr Ala Ser Ser Leu Ser 
        35                  40                  45              


Val Arg Pro Gly Leu Leu Pro Leu Pro Val Val Pro Ser Arg Leu Pro 
    50                  55                  60                  


Thr Pro Ala Thr Ala Pro Ala Pro Cys Thr Thr Gly Ser Ser Glu Ala 
65                  70                  75                  80  


Ile Thr Ser Leu Val Ala Ser Ser Ala Ser Ala Val Thr Thr Lys Ala 
                85                  90                  95      


Pro Gly Ile Ser Lys Gly Asp Ser Gln Ser Gln Gly Leu Ala Thr Ser 
            100                 105                 110         


Ile Arg Trp Gly Gln Thr Pro Ile Asn Gln Ser Thr Pro Trp Asp Thr 
        115                 120                 125             


Asp Glu Pro Pro Ser Lys Gln Met Arg Glu Ser Asp Asn Pro Gly Thr 
    130                 135                 140                 


Gly Pro Trp Val Thr Thr Val Ala Ala Gly Asn Gln Pro Thr Leu Ile 
145                 150                 155                 160 


Ala His Ser Tyr Gly Val Ala Gln Pro Pro Thr Phe Ser Pro Ala Val 
                165                 170                 175     


Asn Val Gln Ala Pro Val Ile Gly Val Thr Pro Ser Leu Pro Pro His 
            180                 185                 190         


Val Gly Pro Gln Leu Pro Leu Met Pro Gly His Tyr Ser Leu Pro Gln 
        195                 200                 205             


Pro Pro Ser Gln Pro Leu Ser Ser Val Val Val Asn Met Pro Ala Gln 
    210                 215                 220                 


Ala Leu Tyr Ala Ser Pro Gln Pro Leu Ala Val Ser Thr Leu Pro Gly 
225                 230                 235                 240 


Val Gly Gln Val Ala Arg Pro Gly Pro Thr Ala Val Gly Asn Gly His 
                245                 250                 255     


Met Ala Gly Pro Leu Leu Pro Pro Pro Pro Pro Ala Gln Pro Ser Ala 
            260                 265                 270         


Thr Leu Pro Ser Gly Ala Pro Ala Thr Asn Gly Pro Pro Thr Thr Asp 
        275                 280                 285             


Ser Ala His Gly Leu Gln Met Leu Arg Thr Ile Gly Val Gly Lys Tyr 
    290                 295                 300                 


Glu Phe Thr Asp Pro Gly His Pro Arg Glu Met Leu Lys Glu Leu Asn 
305                 310                 315                 320 


Gln Gln Arg Arg Ala Lys Ala Phe Thr Asp Leu Lys Ile Val Val Glu 
                325                 330                 335     


Gly Arg Glu Phe Glu Val His Gln Asn Val Leu Ala Ser Cys Ser Leu 
            340                 345                 350         


Tyr Phe Lys Asp Leu Ile Gln Arg Ser Val Gln Asp Ser Gly Gln Gly 
        355                 360                 365             


Gly Arg Glu Lys Leu Glu Leu Val Leu Ser Asn Leu Gln Ala Asp Val 
    370                 375                 380                 


Leu Glu Leu Leu Leu Glu Phe Val Tyr Thr Gly Ser Leu Val Ile Asp 
385                 390                 395                 400 


Ser Ala Asn Ala Lys Thr Leu Leu Glu Ala Ala Ser Lys Phe Gln Phe 
                405                 410                 415     


His Thr Phe Cys Lys Val Cys Val Ser Phe Leu Glu Lys Gln Leu Thr 
            420                 425                 430         


Ala Ser Asn Cys Leu Gly Val Leu Ala Met Ala Glu Ala Met Gln Cys 
        435                 440                 445             


Ser Glu Leu Tyr His Met Ala Lys Ala Phe Ala Leu Gln Ile Phe Pro 
    450                 455                 460                 


Glu Val Ala Ala Gln Glu Glu Ile Leu Ser Ile Ser Lys Asp Asp Phe 
465                 470                 475                 480 


Ile Ala Tyr Val Ser Asn Asp Ser Leu Asn Thr Lys Ala Glu Glu Leu 
                485                 490                 495     


Val Tyr Glu Thr Val Ile Lys Trp Ile Lys Lys Asp Pro Ala Thr Arg 
            500                 505                 510         


Thr Gln Tyr Ala Ala Glu Leu Leu Ala Val Val Arg Leu Pro Phe Ile 
        515                 520                 525             


His Pro Ser Tyr Leu Leu Asn Val Val Asp Asn Glu Glu Leu Ile Lys 
    530                 535                 540                 


Ser Ser Glu Ala Cys Arg Asp Leu Val Asn Glu Ala Lys Arg Tyr His 
545                 550                 555                 560 


Met Leu Pro His Ala Arg Gln Glu Met Gln Thr Pro Arg Thr Arg Pro 
                565                 570                 575     


Arg Leu Ser Ala Gly Val Ala Glu Val Ile Val Leu Val Gly Gly Arg 
            580                 585                 590         


Gln Met Val Gly Met Thr Gln Arg Ser Leu Val Ala Val Thr Cys Trp 
        595                 600                 605             


Asn Pro Gln Asn Asn Lys Trp Tyr Pro Leu Ala Ser Leu Pro Phe Tyr 
    610                 615                 620                 


Asp Arg Glu Phe Phe Ser Val Val Ser Ala Gly Asp Asn Ile Tyr Leu 
625                 630                 635                 640 


Ser Gly Gly Met Glu Ser Gly Val Thr Leu Ala Asp Val Trp Cys Tyr 
                645                 650                 655     


Met Ser Leu Leu Asp Asn Trp Asn Leu Val Ser Arg Met Thr Val Pro 
            660                 665                 670         


Arg Cys Arg His Asn Ser Leu Val Tyr Asp Gly Lys Ile Tyr Thr Leu 
        675                 680                 685             


Gly Gly Leu Gly Val Ala Gly Asn Val Asp His Val Glu Arg Tyr Asp 
    690                 695                 700                 


Thr Ile Thr Asn Gln Trp Glu Ala Val Ala Pro Leu Pro Lys Ala Val 
705                 710                 715                 720 


His Ser Ala Ala Ala Thr Val Cys Gly Gly Lys Ile Tyr Val Phe Gly 
                725                 730                 735     


Gly Val Asn Glu Ala Gly Arg Ala Ala Gly Val Leu Gln Ser Tyr Val 
            740                 745                 750         


Pro Gln Thr Asn Thr Trp Ser Phe Ile Glu Ser Pro Met Ile Asp Asn 
        755                 760                 765             


Lys Tyr Ala Pro Ala Val Thr Leu Asn Gly Phe Val Phe Ile Leu Gly 
    770                 775                 780                 


Gly Ala Tyr Ala Arg Ala Thr Thr Ile Tyr Asp Pro Glu Lys Gly Asn 
785                 790                 795                 800 


Ile Lys Ala Gly Pro Asn Met Asn His Ser Arg Gln Phe Cys Ser Ala 
                805                 810                 815     


Val Val Leu Asp Gly Lys Ile Tyr Ala Thr Gly Gly Ile Val Ser Ser 
            820                 825                 830         


Glu Gly Pro Ala Leu Gly Asn Met Glu Ala Tyr Glu Pro Thr Thr Asn 
        835                 840                 845             


Thr Trp Thr Leu Leu Pro His Met Pro Cys Pro Val Phe Arg His Gly 
    850                 855                 860                 


Cys Val Val Ile Lys Lys Tyr Ile Gln Ser Gly 
865                 870                 875 


<210>  25
<211>  4434
<212>  DNA
<213>  Homo sapiens

<400>  25
atatttggac tcggctgccc gtgcccagga atttcccgtc atgcctcccg ccgccccgtc       60

cgtcgcccgg agccggggag ggagggagcg aggttcggac accggcggcg gctgcctggc      120

ctttccatga gcccgcggcg gaccctcccg cgccccctct cgctctgcct ctccctctgc      180

ctctgcctct gcctggccgc ggctctggga agtgcgcagt ccgctcttgc ccctgttctt      240

tgcttctcgt tttgttggtg aagatatcac agtgatgtct gcattcaacc tgctgcattt      300

ggtgacaaag agccagccag tagcccttcg agcctgtggg cttccctcag ggtcgtgtag      360

ggataaaaag aactgtaagg tggtcttttc ccagcaggaa ctgaggaagc ggctaacacc      420

cctgcagtac catgtcactc aggagaaagg gaccgaaagt gcctttgaag gagaatacac      480

acatcacaaa gatcctggaa tatataaatg tgttgtttgt ggaactccat tgtttaagtc      540

agaaaccaaa tttgactccg gttcaggttg gccttcattc cacgatgtga tcaattctga      600

ggcaatcaca ttcacagatg acttttccta tgggatgcac agggtggaaa caagctgctc      660

tcagtgtggt gctcaccttg ggcacatttt tgatgatggg cctcgtccaa ctgggaaaag      720

atactgcata aattcggctg ccttgtcttt tacacctgcg gatagcagtg gcaccgccga      780

gggaggcagt ggggtcgcca gcccggccca ggcagacaaa gcggagctct agagtaatgg      840

agagtgatgg aaacaaagtg tacttaatgc acagcttatt aaaaaaatca aaattgttat      900

cttaatagat atattttttc aaaaactata agggcagttt tgtgctattg atattttttc      960

ttcttttgct taaacagaag ccctggccat ccatgtattt tgcaattgac tagatcaaga     1020

actgtttata gctttagcaa atggagacag ctttgtgaaa cttcttcaca agccacttat     1080

accctttggc attcttttct ttgagcacat ggcttctttt gcagtttttc cccctttgat     1140

tcagaagcag agggttcatg gtcttcaaac atgaaaatag agatctcctc tgcagtgtag     1200

agaccagagc tgggcagtgc agggcatgga gacctgcaag acacatggcc ttgaggcctt     1260

tgcacagacc cacctaagat aaggttggag tgatgtttta atgagactgt tcagctttgt     1320

ggaaagtttg agctaaggtc attttttttt ttctcactga aagggtgtga aggtctaaag     1380

tctttcctta tgttaaattg ttgccagatc caaaggggca tactgagtgt tgtggcagag     1440

aagtaaacat taccacactg ttaggccttt attttatttt attttccatc gaaagcattg     1500

gaggcccagt gcaatggctc acgcctgtga tcccagcact ttgggaggcc aaggcgggtg     1560

gatcacgagg tcaggagatg gagaccatcc tggctaacat ggtgaaaccc cgtctctact     1620

aaaaatacga aaaattagcc aggcgtggtg gtgggcacct gtagtcccag ctactcagga     1680

ggctgaggca ggagaatggc gtgaacccgg aaggcggagc ttgcagttag ccgagatcat     1740

gccactgcac tccagcctac atgacaatgt gacactccat ctcaaaaaat aataataata     1800

acaatataag aactagctgg gcatggtggc gcatgcatgt agtcccagct actcctgagg     1860

ctcagtcagg agaatcgctt gaacttggga ggcggaggtt gcagtgagct gagctcatac     1920

cactgcactc cagcctgaac agagtgagat cctgtcaaaa aagaaaagaa aaagaaagca     1980

gcattcaaat gtaagacaac tgtaaaatat tgagccccac ttggtctaaa attcaaaaag     2040

aagaacgcct gtccatcgcc tttttataag tccttctctc cacacctaaa agcagctgca     2100

gctggaaggg cacaaattcc actgtgtaaa ataaaatatt aggggcaaca cacttcatca     2160

aggcagcagg aatgagagag agcagagaag atcaaggatg aagtcttggg tactgaaaaa     2220

ttcagtgctg ggcagaaaaa ctgacagggc agtacaagta acaaacagaa tccaagtggg     2280

gtggcccttg tgcacagagc tccaggtgac ctctggagag acatgggcat tcacatggaa     2340

agctaaaacg gaagctcaag tttcatactc aacataatct tctgtgtgac aaaggacaag     2400

ccatgtagcc tctctgtgcc tatttcttca tgcataaact gggactcata atatttgtaa     2460

aatgtattga tactctcagg gcaaattcac tatattgcta tacagttgag atcagtgttg     2520

taaaattaaa ctgatctggt tctaattgcc tcaaaggcca aagcccaggc atttgaaatg     2580

gaaagaagca gagaggaggc tgacttagct gattggtatg gaaacagttg ggccaagagc     2640

cagaatttcc ctttgtagca acacggctag ttttactttg agaagctctg ctcagctgct     2700

ttataacatt aagtctggcg gaatggatgt cactgtgcac aataaagttt tcacaagtat     2760

aaacaatggt gatgtaagtc aacattgctg tagccaggtg tgaaggttgt atggtgtgtg     2820

acgaatgtac atcatgtttg taggtttgga tgctaatctt gaattgtagt ttaaaaaata     2880

cgtatttttg taactctttg aaagtttatg aagactgaca gctttccttg taagcactaa     2940

gagaaaaaaa agaaagaggg acatttgaca attttaaaga aacaacaaga aattagaatg     3000

aaaatctgtg acaaacagcg tcagtgtggc catgtccaca ttcctacatg tctctctcta     3060

caagcacctc tctaagaagc ctgacatccc ggtggactct ttatagtcat gtacacttga     3120

ttccagatga gctctggtct tatctggatg ctcagataag aggtttctat ctgagcatcc     3180

agatgttccc tcaggttcca agacatttca ccccaggccc tgggttcact ctggaattcg     3240

taggcttcac gtctctctag aaatgacgtg taaaatttaa gaccagacct cagccatcag     3300

cgtccagacc atcctagaag tctttcccaa tctcacagag aaagccctag tatttcccag     3360

tgaccccagg attccacgtt ggggtggcca aagaaatagg tctctcaggg ctttgccaca     3420

gcctccagcc catccttcag aggcacacac agcacctctc ggctgctcca gctctgtagg     3480

atagcctccc ctggggtccg tgggacgcgg gccacagtgt tgaggtagac aaggaggatc     3540

agtgagaggc ctcttccctc tccacagaga ctggattgtc attgttcctt catttatatc     3600

gtagggctta acatttcact caaaaaaaag cccctctttt tctaatcctt agtctttgtt     3660

tcaaggaaag ccagtttttc ttctaccaca ttttccagga tcgactttaa gaaaaatgca     3720

acatctattg aaaaaaagtg gggtgtatgc atgtggttta attccagatt gcttttgggt     3780

ttaagtggta tcaaatttca gtatatttct gtcttatgtg aaagaaatat attactaaaa     3840

cgtcagtgag caataatgtc agctgtcaag cactagattt atttttgcag gatatggagt     3900

gcaatgaact gagtcaatat ggcaaggtgt atgtgatctg tgggagttat gccatttaac     3960

ataggaagtg catgggactt tccctctctg cactccagct cttactgtac cattagaaga     4020

tgcagaattc tgttggtgtg caaaaagtat agccttacat tcaagcagaa tggatctgaa     4080

gaaagcagca atatctgtta ctagagaaca ttcccatgtg tttaaactct tcacttctta     4140

gatgcattta aattcttaat gcaaatgacg tagcaatttg aaaacttctc cgtattactt     4200

gtgtttaaaa tgtcttgctt taaatacaaa acaaatggta aaggggatta tcttttgttt     4260

agatggttaa atattatttt tgccttagat agctttgtaa taatttttct ccagacagtt     4320

caacactttt gaaaaatgac atgaattttc attaaaaacc cttttcctat gtttattgta     4380

tacaagaatt atgcaataaa atttctttat aaaaataaaa aaaaaaaaaa aaaa           4434


<210>  26
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
        115                 120                 125             


Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg 
    130                 135                 140                 


Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr 
145                 150                 155                 160 


Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser 
                165                 170                 175     


Pro Ala Gln Ala Asp Lys Ala Glu Leu 
            180                 185 


<210>  27
<211>  9520
<212>  DNA
<213>  Homo sapiens

<400>  27
gcctcctccc cacacctggg aggggagtgg tgcggcgcgg cctcctcccc cggcgctcgc       60

aactcctgtc cggccgtagc tgcgccgccg cggcgggagt aaaggtcgcg ccgccgggag      120

cgagccggcc gcggcgcctg cgggaagccg gcggggcagg tcggagaaga gcgagaagat      180

cgagaaactc caggccagcc cgggaacatg gcgccaggcg ggccagccgc ggactgagag      240

ccgcggggca gccaggagcc ggggcccgag ccccgcccgg cccgggccat gtcggtgggc      300

gagctctaca gccagtgcac aagggtctgg atccctgacc ctgatgaggt atggcgctca      360

gctgagttaa ccaaggacta caaagaagga gacaagagcc tacagctcag actggaggat      420

gaaacgattc tggaataccc aattgatgta caacgcaacc agctgccctt cttacggaat      480

ccagatatct tggtgggaga aaatgacctg actgccctta gctatcttca tgagcctgca      540

gttttgcata atttgaaggt ccgtttcctg gagtccaacc atatctacac ttactgtggt      600

atcgtacttg ttgccattaa tccttatgaa cagttgccaa tctatggaca agatgtcatc      660

tatacctaca gtggccaaaa catgggagac atggaccccc acatctttgc tgtggcagaa      720

gaagcctaca agcagatggc cagagatgag aagaatcagt ccatcatagt cagtggggag      780

tctggagccg ggaagacggt atcagccaag tatgccatgc gctatttcgc caccgttggt      840

ggctcggcca gtgaaaccaa catcgaagag aaggtgctgg catccagtcc catcatggag      900

gccattggaa atgccaagac cacccgcaat gacaacagca gccgttttgg caagtacatc      960

cagattggct ttgacaaaag gtaccacatc atcggggcca acatgaggac ttacctcttg     1020

gagaagtcca gagtggtctt ccaggcagat gatgagagga attaccacat cttttaccag     1080

ctctgtgctg ctgccggtct tccagaattt aaagagcttg cactaacaag tgcagaggac     1140

tttttctata catcacaggg aggagacact tccatcgagg gtgtggacga tgctgaggac     1200

tttgagaaga ctcgacaagc cttcacactc ctcggagtga aagagtccca tcagatgagc     1260

atttttaaga taattgcttc tatcttgcac cttggaagtg tggcgattca ggctgagcgt     1320

gatggtgatt cctgtagtat atcaccccag gatgtatacc taagcaactt ctgccgactg     1380

ctaggggtgg agcacagtca gatggagcac tggctgtgtc atcgcaagct ggtcaccacc     1440

tcggagacct acgtcaagac catgtccctg cagcaggtga tcaatgcgcg caacgccctg     1500

gcgaagcaca tctatgccca gttgttcggc tggattgtgg agcacatcaa caaggccctg     1560

cacacctccc tcaagcagca ctccttcatc ggggtcctgg acatctatgg gtttgagaca     1620

tttgaggtaa acagctttga gcagttctgt atcaactatg caaatgaaaa gctccagcag     1680

cagttcaact cgcatgtttt caaactggag caagaagaat acatgaagga acagatccct     1740

tggaccctga ttgattttta tgataaccaa ccttgtatcg acctcattga agccaagctg     1800

ggtatcttgg acctgttgga tgaagaatgt aaggtcccca aaggaactga ccagaactgg     1860

gctcagaagc tctatgaccg gcactccagc agccagcact tccagaagcc ccgcatgtcc     1920

aacacggcct tcatcatcgt ccactttgca gacaaggtgg agtacctctc tgatggtttt     1980

ctggagaaaa acagagacac ggtgtatgaa gagcagatca atatcctgaa ggccagcaag     2040

ttcccactag tggctgactt gtttcatgat gacaaggacc ctgttcctgc caccacccct     2100

gggaaggggt catcttcgaa gatcagcgtc cgttctgcca gaccccccat gaaagtctcc     2160

aacaaggagc acaagaaaac cgttggccac cagttccgta cctccctgca tctgctcatg     2220

gagaccctga atgccacgac acctcactat gtccgctgca tcaagcccaa cgatgagaag     2280

ctcccctttc actttgaccc aaagagagca gtgcagcaac tcagagcctg cggggtgttg     2340

gagacgattc gaatcagtgc agctggctac ccatccaggt gggcctacca tgactttttc     2400

aaccggtatc gggtgctggt caagaagaga gagctcgcca acacagacaa aaaggccatc     2460

tgcaggtctg tcctggagaa cctcatcaag gaccccgaca agttccagtt tggccgcacc     2520

aagatcttct ttcgagcagg ccaggtggcc tacctggaga agctgcgggc tgacaagttc     2580

cggacagcca ccatcatgat ccagaaaact gtccggggat ggctgcagaa ggtgaaatat     2640

cacaggctga agggggctac cttaaccctg cagaggtact gccggggaca cctggcccgc     2700

aggctggctg agcacctgcg gaggatcaga gcggctgtgg tgctccagaa acattaccgc     2760

atgcagaggg cccgccaggc ctaccagagg gtccgcagag ctgccgttgt tatccaggcc     2820

ttcacccggg ccatgtttgt gcggagaacc taccgccagg tcctcatgga gcacaaggcc     2880

accaccatcc agaagcacgt gcggggctgg atggcacgca ggcacttcca gcggctgcgg     2940

gatgcagcca ttgtcatcca gtgtgccttc cggatgctca aggccaggcg ggagctgaag     3000

gccctcagga ttgaggcccg ctcagcagag catctgaaac gtctcaacgt gggcatggag     3060

aacaaggtgg tccagctgca gcggaagatc gatgagcaga acaaagagtt caagacactt     3120

tcagagcagt tgtccgtgac cacctcaaca tacaccatgg aggtagagcg gctgaagaag     3180

gagctggtgc actaccagca gagcccaggt gaggacacca gcctcaggct gcaggaggag     3240

gtggagagcc tgcgcacaga gctgcagagg gcccactcgg agcgcaagat cttggaggac     3300

gcccacagca gggagaaaga tgagctgagg aagcgagttg cagacctgga gcaagaaaat     3360

gctctcttga aagatgagaa agaacagctc aacaaccaaa tcctgtgcca gtctaaagat     3420

gaatttgccc agaactctgt gaaggaaaat ctcatgaaga aagaactgga ggaggagcga     3480

tcccggtacc agaaccttgt gaaggaatat tcacagttgg agcagagata cgacaacctt     3540

cgggatgaaa tgaccatcat aaagcaaact ccaggtcata ggcggaaccc atcaaaccaa     3600

agtagcttag aatctgactc caattacccc tccatctcca catctgagat cggagacact     3660

gaggatgccc tccagcaggt ggaggaaatt ggcctggaga aggcagccat ggacatgacg     3720

gtcttcctga agctgcagaa gagagtacgg gagctggagc aggagaggaa aaagctgcaa     3780

gtgcagctgg agaagagaga acagcaggac agcaagaaag tccaggcgga accaccacag     3840

actgacatag atttggaccc gaatgcagat ctggcctaca atagtctgaa gaggcaagag     3900

ctggagtcag agaacaaaaa gctgaagaat gacctgaatg agctgaggaa agccgtggcc     3960

gaccaagcca cgcagaataa ctccagccac ggctccccag atagctacag cctcctgctg     4020

aaccagctca agctggccca cgaggagctc gaggtgcgca aggaggaggt gctcatcctc     4080

aggacccaga tcgtgagcgc cgaccagcgg cgactcgccg gcaggaacgc ggagccgaac     4140

attaatgcca gatcaagttg gcctaacagt gaaaagcatg ttgaccagga ggatgccatt     4200

gaggcctatc acggggtctg ccagacaaac agcaagactg aggattgggg atatttaaat     4260

gaagatggag aactcggctt ggcctaccaa ggcctaaagc aagttgccag gctgctggag     4320

gctcagctgc aggcccagag cctggagcat gaggaggagg tggagcatct caaggctcag     4380

ctcgaggccc tgaaggagga gatggacaaa cagcagcaga ccttctgcca gacgctactg     4440

ctctccccag aggcccaggt ggaattcggc gttcagcagg aaatatcccg gctgaccaac     4500

gagaatctgg accttaaaga actggtagaa aagctggaaa agaatgagag gaagctcaaa     4560

aagcaactga agatttacat gaagaaagcc caggacctag aagctgccca ggcattggcc     4620

cagagtgaga ggaagcgcca tgagctcaac aggcaggtca cggtccagcg gaaagagaag     4680

gatttccagg gcatgctgga gtaccacaaa gaggacgagg ccctcctcat ccggaacctg     4740

gtgacagact tgaagcccca gatgctgtcg ggcacagtgc cctgtctccc cgcctacatc     4800

ctctacatgt gcatccggca cgcggactac accaacgacg atctcaaggt gcactccctg     4860

ctgacctcca ccatcaacgg cattaagaaa gtcctgaaaa agcacaatga tgactttgag     4920

atgacgtcat tctggttatc caacacctgc cgccttcttc actgtctgaa gcagtacagc     4980

ggggatgagg gcttcatgac tcagaacact gcaaagcaga atgaacactg tcttaagaat     5040

tttgacctca ccgaataccg tcaggtgctg agtgaccttt ccattcagat ctaccagcag     5100

ctcattaaaa ttgccgaggg cgtgttacag ccgatgatag tttctgccat gttggaaaat     5160

gagagcattc agggtctatc tggtgtgaag cccaccggct accggaagcg ctcctccagc     5220

atggcagatg gggataactc atactgcctg gaagctatca tccgccagat gaatgccttt     5280

catacagtca tgtgtgacca gggcttggac cctgagatca tcctgcaggt attcaaacag     5340

ctcttctaca tgatcaacgc agtgactctt aacaacctgc tcttgcggaa ggacgtctgc     5400

tcttggagca caggcatgca actcaggtac aatataagtc agcttgagga gtggcttcgg     5460

ggaagaaacc ttcaccagag tggagcagtt cagaccatgg aacctctgat ccaagcagcc     5520

cagctcctgc aattaaagaa gaaaacccag gaggacgcag aggctatctg ctccctgtgt     5580

acctccctca gcacccagca gattgtcaaa attttaaacc tttatactcc cctgaatgaa     5640

tttgaagaac gggtaacagt ggcctttata cgaacaatcc aggcacaact acaagagcgg     5700

aatgaccctc agcaactgct attagatgcc aagcacatgt ttcctgtttt gtttccattt     5760

aatccatctt ctctaaccat ggactcaatc cacatcccag cgtgtctcaa tctggaattc     5820

ctcaatgaag tctgaagatg catgtttcca gcattagttt gattcccaat gtgagcaaga     5880

aggaagtata tacagtaaag taaattcaag gatctgttaa atctggtaaa agtagatcaa     5940

atcagagatt gacagcctgt ggagggtgct gaactataca gaattagaca caactatgtc     6000

attatttttt gtacctactg ctcagaataa aaacacttga aatatggaag attttaagtt     6060

tgatttcagt ccaacacata tacataattt atagacacca agcagtcccc atagacatat     6120

aaaaggtgtc aattctataa aacgaagctg cctagttttg atctttgcat agaactagag     6180

aatgtccaaa ttaaaatacc aaatatatat aagtcacata aattgccttc aaagggcttt     6240

aacaaataat ggtactaata accatgataa tggcatatac tgacatttcc caaagtttgc     6300

aaaccatagg tgtggttgag tttgtggtga gatgttttaa gaacaaaaat atggggatga     6360

gacttctgag aaatattccc aaaatatttt ttaatggctg attatacaca gacagtggtg     6420

taactgacct ccagaccaga cattttgagt actggtttct gaagcaaaat tagaagtgcc     6480

agtcctcagt gtgctcaaac gcttttgtgt tatcttgatt taatggaaga gattattaaa     6540

atgctgctat cccaaactcc aagtgagaaa gatggaaaaa tattttgttt ctgatgctag     6600

tccatacact ttccaagtcc cacaaaactt tcacaaaaat gtatataagc taaatattag     6660

aaacggataa caaacttgtt ttatttatag atgtaaaaac caaacaagtc aatatgaaag     6720

cttttaatct cttaatacca ttaagcttcc agtaagagca tcacataatg ctctactgtt     6780

ccagaaacca aatagtaaaa caaactaaag ttcgcacatc agatcatctg aaaaaccttc     6840

aaaaataatc agttcaggga tattatacaa aagtttgggt tttttttttt taagagaata     6900

aaatggctta ggtcaacttt cccttttcag gttattttca acgtttttca aatttagcac     6960

acaaaaaatt gtaaatatct ctcccacaaa ataaggattt taaaaaagta attcagtaat     7020

ataacaggct tagatgtttg ctgctcttag aatttttttt aacttgtttt tggtttcttc     7080

aaaagcaagc attcaattgg aaacccatat tctttccaca ctttttttta ctgtcttttc     7140

tgtatttctt gatagcagta tgctgttccc ataagaaaaa aatggtattt gcaaatcatg     7200

gaagaacagc ctctgtatta cattgagaaa ataagattta tccatgaatt ggaagtagaa     7260

cagcctgcct tcaccctctt ttactcaacc acccaactta aaaggctctt ggaaacacag     7320

cacactccac gctaccttct gcactgtgcc cttagagcac agcttcctca gttgttctct     7380

gcatctcctg gggcttaggc cagtcttagc ctgggttaag gctgctgaca ttgtgttcca     7440

atcagttgtc atgggcatta tcccctctac atccacatta aacatgccgg cttctcttgg     7500

gcatcggcag agctgtgcct ttttctttca gttacagtta cataatcact gacgtccatg     7560

acacttaccc atggatccat gtgctgactt catttagaag gccaatctaa aacaactggg     7620

tttgtggcta cctctttaaa gttgtttgtg aaggataatt tgttttttaa tgcactttag     7680

tttgaaagtg agtctcttat gtaaggacca tccttaaaag accaaaaatg ccttgttaga     7740

gtgttaagga gttttgacat gcagtggttc cacaaacaca gtggcttact atccttatac     7800

actgtcttat accatcattc tctccatctc tcttggtcac tactctctgc tgtcactggt     7860

taatcactag gtgccaagag cttactgaat aaaagcttgg caattagaat aaatggggag     7920

ggaaggacct tatgaatagt ccatttagcc taagaaatgg cagatttagt tcttctcttc     7980

caaaagataa aggtatatcc tggaattgta cttaaaactt acagatgact aacaaatata     8040

tactttatat gtagttaata tttagatctg tcttatttaa tacttggagg ctagaagaag     8100

catctttagg ggaactatat aatcttttgt tagcattttc tctgcatttt aaaaaatcat     8160

ttcaattcaa acatttatca gtgtcatgaa atcagtaatg actctttaac aattcaggtt     8220

tgaactctgc attagatgtc tctttaattt tttaatattt aaaatttagt tgacattttt     8280

ttcaccaggt gcctttagcg gttactaaga taactgacat cagttgtttc tctgaaataa     8340

gtgttgctgt gggaataatt ttaatgttca aggtgatatc atgggggagt tttgtctttt     8400

aaaacattag aagcatttta aatattaaga atcaaatatt tatagatcaa aacttgtgtt     8460

ttaagtatta tacgggacct gtttacttat agtaaatgtg aatgtacaca tgagttgttg     8520

ctgaagctga caagcatatt acatacatgc attttccctg tgccctcata gttgcagtta     8580

gagttccagt acctgtaggc tcacctggga ggcagattag acccaaaggt agatgttttt     8640

cccctttcca tgaagcatgt cagtgggagt tgcttccttt gatttcccta gtactaaatt     8700

ttaaggcttt tgtaaaaaca aaacaaaact aggagcttgg aacagttaaa aatcaacact     8760

gctaccatca attcatcaaa tatttactta gagctttcat acattaagat tccagtaacc     8820

aataaattag aattcatttc ttctgcataa agtaaatttt catacacttg acctactaag     8880

acagcaaggg tgtcctaaat tgaggcattt gtataatgcc tgcataacta aatggtcact     8940

aaaatgggac agcatggggc aagaccttgt agttcttcac agaatatttg tggtcagttt     9000

ctccaattaa tttgctgcat gagccaaata accataattc actttttata cccactggtg     9060

ccataattag agaattagag ggtgtagaca gaggttaatg ccaatgagaa acacaggaca     9120

gggttttttt tattataaag gtcattagat acaaaagatt gtttttcaaa aaatttctaa     9180

ttctaacaaa ggggatcaat cagaaatgaa actaagctac tttctaaagt gacactgtat     9240

cagaataatc cagatttgaa tataacattt tgccaccaac tgacatttag atgaaggact     9300

gcctctctga aagagttcag atcatattca ggggtgaatc caacaccatg gaagaaagac     9360

tactgatgaa aatattttcc cactttgcac aaatctgtaa actacacctt tgtttataga     9420

aaaatgcttg taatagtcac tgtaatattt agctgtggat aaaaatttgt ggaaataaat     9480

acttttgaat aaagaggtgt gccaaatcta aatgaaattt                           9520


<210>  28
<211>  1848
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Val Gly Glu Leu Tyr Ser Gln Cys Thr Arg Val Trp Ile Pro 
1               5                   10                  15      


Asp Pro Asp Glu Val Trp Arg Ser Ala Glu Leu Thr Lys Asp Tyr Lys 
            20                  25                  30          


Glu Gly Asp Lys Ser Leu Gln Leu Arg Leu Glu Asp Glu Thr Ile Leu 
        35                  40                  45              


Glu Tyr Pro Ile Asp Val Gln Arg Asn Gln Leu Pro Phe Leu Arg Asn 
    50                  55                  60                  


Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu 
65                  70                  75                  80  


His Glu Pro Ala Val Leu His Asn Leu Lys Val Arg Phe Leu Glu Ser 
                85                  90                  95      


Asn His Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro 
            100                 105                 110         


Tyr Glu Gln Leu Pro Ile Tyr Gly Gln Asp Val Ile Tyr Thr Tyr Ser 
        115                 120                 125             


Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu 
    130                 135                 140                 


Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Lys Asn Gln Ser Ile Ile 
145                 150                 155                 160 


Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala 
                165                 170                 175     


Met Arg Tyr Phe Ala Thr Val Gly Gly Ser Ala Ser Glu Thr Asn Ile 
            180                 185                 190         


Glu Glu Lys Val Leu Ala Ser Ser Pro Ile Met Glu Ala Ile Gly Asn 
        195                 200                 205             


Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile 
    210                 215                 220                 


Gln Ile Gly Phe Asp Lys Arg Tyr His Ile Ile Gly Ala Asn Met Arg 
225                 230                 235                 240 


Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Asp Asp Glu 
                245                 250                 255     


Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ala Ala Gly Leu Pro 
            260                 265                 270         


Glu Phe Lys Glu Leu Ala Leu Thr Ser Ala Glu Asp Phe Phe Tyr Thr 
        275                 280                 285             


Ser Gln Gly Gly Asp Thr Ser Ile Glu Gly Val Asp Asp Ala Glu Asp 
    290                 295                 300                 


Phe Glu Lys Thr Arg Gln Ala Phe Thr Leu Leu Gly Val Lys Glu Ser 
305                 310                 315                 320 


His Gln Met Ser Ile Phe Lys Ile Ile Ala Ser Ile Leu His Leu Gly 
                325                 330                 335     


Ser Val Ala Ile Gln Ala Glu Arg Asp Gly Asp Ser Cys Ser Ile Ser 
            340                 345                 350         


Pro Gln Asp Val Tyr Leu Ser Asn Phe Cys Arg Leu Leu Gly Val Glu 
        355                 360                 365             


His Ser Gln Met Glu His Trp Leu Cys His Arg Lys Leu Val Thr Thr 
    370                 375                 380                 


Ser Glu Thr Tyr Val Lys Thr Met Ser Leu Gln Gln Val Ile Asn Ala 
385                 390                 395                 400 


Arg Asn Ala Leu Ala Lys His Ile Tyr Ala Gln Leu Phe Gly Trp Ile 
                405                 410                 415     


Val Glu His Ile Asn Lys Ala Leu His Thr Ser Leu Lys Gln His Ser 
            420                 425                 430         


Phe Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Val Asn 
        435                 440                 445             


Ser Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln 
    450                 455                 460                 


Gln Phe Asn Ser His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys 
465                 470                 475                 480 


Glu Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys 
                485                 490                 495     


Ile Asp Leu Ile Glu Ala Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu 
            500                 505                 510         


Glu Cys Lys Val Pro Lys Gly Thr Asp Gln Asn Trp Ala Gln Lys Leu 
        515                 520                 525             


Tyr Asp Arg His Ser Ser Ser Gln His Phe Gln Lys Pro Arg Met Ser 
    530                 535                 540                 


Asn Thr Ala Phe Ile Ile Val His Phe Ala Asp Lys Val Glu Tyr Leu 
545                 550                 555                 560 


Ser Asp Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Glu Glu Gln 
                565                 570                 575     


Ile Asn Ile Leu Lys Ala Ser Lys Phe Pro Leu Val Ala Asp Leu Phe 
            580                 585                 590         


His Asp Asp Lys Asp Pro Val Pro Ala Thr Thr Pro Gly Lys Gly Ser 
        595                 600                 605             


Ser Ser Lys Ile Ser Val Arg Ser Ala Arg Pro Pro Met Lys Val Ser 
    610                 615                 620                 


Asn Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg Thr Ser Leu 
625                 630                 635                 640 


His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His Tyr Val Arg 
                645                 650                 655     


Cys Ile Lys Pro Asn Asp Glu Lys Leu Pro Phe His Phe Asp Pro Lys 
            660                 665                 670         


Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu Thr Ile Arg 
        675                 680                 685             


Ile Ser Ala Ala Gly Tyr Pro Ser Arg Trp Ala Tyr His Asp Phe Phe 
    690                 695                 700                 


Asn Arg Tyr Arg Val Leu Val Lys Lys Arg Glu Leu Ala Asn Thr Asp 
705                 710                 715                 720 


Lys Lys Ala Ile Cys Arg Ser Val Leu Glu Asn Leu Ile Lys Asp Pro 
                725                 730                 735     


Asp Lys Phe Gln Phe Gly Arg Thr Lys Ile Phe Phe Arg Ala Gly Gln 
            740                 745                 750         


Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Phe Arg Thr Ala Thr 
        755                 760                 765             


Ile Met Ile Gln Lys Thr Val Arg Gly Trp Leu Gln Lys Val Lys Tyr 
    770                 775                 780                 


His Arg Leu Lys Gly Ala Thr Leu Thr Leu Gln Arg Tyr Cys Arg Gly 
785                 790                 795                 800 


His Leu Ala Arg Arg Leu Ala Glu His Leu Arg Arg Ile Arg Ala Ala 
                805                 810                 815     


Val Val Leu Gln Lys His Tyr Arg Met Gln Arg Ala Arg Gln Ala Tyr 
            820                 825                 830         


Gln Arg Val Arg Arg Ala Ala Val Val Ile Gln Ala Phe Thr Arg Ala 
        835                 840                 845             


Met Phe Val Arg Arg Thr Tyr Arg Gln Val Leu Met Glu His Lys Ala 
    850                 855                 860                 


Thr Thr Ile Gln Lys His Val Arg Gly Trp Met Ala Arg Arg His Phe 
865                 870                 875                 880 


Gln Arg Leu Arg Asp Ala Ala Ile Val Ile Gln Cys Ala Phe Arg Met 
                885                 890                 895     


Leu Lys Ala Arg Arg Glu Leu Lys Ala Leu Arg Ile Glu Ala Arg Ser 
            900                 905                 910         


Ala Glu His Leu Lys Arg Leu Asn Val Gly Met Glu Asn Lys Val Val 
        915                 920                 925             


Gln Leu Gln Arg Lys Ile Asp Glu Gln Asn Lys Glu Phe Lys Thr Leu 
    930                 935                 940                 


Ser Glu Gln Leu Ser Val Thr Thr Ser Thr Tyr Thr Met Glu Val Glu 
945                 950                 955                 960 


Arg Leu Lys Lys Glu Leu Val His Tyr Gln Gln Ser Pro Gly Glu Asp 
                965                 970                 975     


Thr Ser Leu Arg Leu Gln Glu Glu Val Glu Ser Leu Arg Thr Glu Leu 
            980                 985                 990         


Gln Arg Ala His Ser Glu Arg Lys  Ile Leu Glu Asp Ala  His Ser Arg 
        995                 1000                 1005             


Glu Lys  Asp Glu Leu Arg Lys  Arg Val Ala Asp Leu  Glu Gln Glu 
    1010                 1015                 1020             


Asn Ala  Leu Leu Lys Asp Glu  Lys Glu Gln Leu Asn  Asn Gln Ile 
    1025                 1030                 1035             


Leu Cys  Gln Ser Lys Asp Glu  Phe Ala Gln Asn Ser  Val Lys Glu 
    1040                 1045                 1050             


Asn Leu  Met Lys Lys Glu Leu  Glu Glu Glu Arg Ser  Arg Tyr Gln 
    1055                 1060                 1065             


Asn Leu  Val Lys Glu Tyr Ser  Gln Leu Glu Gln Arg  Tyr Asp Asn 
    1070                 1075                 1080             


Leu Arg  Asp Glu Met Thr Ile  Ile Lys Gln Thr Pro  Gly His Arg 
    1085                 1090                 1095             


Arg Asn  Pro Ser Asn Gln Ser  Ser Leu Glu Ser Asp  Ser Asn Tyr 
    1100                 1105                 1110             


Pro Ser  Ile Ser Thr Ser Glu  Ile Gly Asp Thr Glu  Asp Ala Leu 
    1115                 1120                 1125             


Gln Gln  Val Glu Glu Ile Gly  Leu Glu Lys Ala Ala  Met Asp Met 
    1130                 1135                 1140             


Thr Val  Phe Leu Lys Leu Gln  Lys Arg Val Arg Glu  Leu Glu Gln 
    1145                 1150                 1155             


Glu Arg  Lys Lys Leu Gln Val  Gln Leu Glu Lys Arg  Glu Gln Gln 
    1160                 1165                 1170             


Asp Ser  Lys Lys Val Gln Ala  Glu Pro Pro Gln Thr  Asp Ile Asp 
    1175                 1180                 1185             


Leu Asp  Pro Asn Ala Asp Leu  Ala Tyr Asn Ser Leu  Lys Arg Gln 
    1190                 1195                 1200             


Glu Leu  Glu Ser Glu Asn Lys  Lys Leu Lys Asn Asp  Leu Asn Glu 
    1205                 1210                 1215             


Leu Arg  Lys Ala Val Ala Asp  Gln Ala Thr Gln Asn  Asn Ser Ser 
    1220                 1225                 1230             


His Gly  Ser Pro Asp Ser Tyr  Ser Leu Leu Leu Asn  Gln Leu Lys 
    1235                 1240                 1245             


Leu Ala  His Glu Glu Leu Glu  Val Arg Lys Glu Glu  Val Leu Ile 
    1250                 1255                 1260             


Leu Arg  Thr Gln Ile Val Ser  Ala Asp Gln Arg Arg  Leu Ala Gly 
    1265                 1270                 1275             


Arg Asn  Ala Glu Pro Asn Ile  Asn Ala Arg Ser Ser  Trp Pro Asn 
    1280                 1285                 1290             


Ser Glu  Lys His Val Asp Gln  Glu Asp Ala Ile Glu  Ala Tyr His 
    1295                 1300                 1305             


Gly Val  Cys Gln Thr Asn Ser  Lys Thr Glu Asp Trp  Gly Tyr Leu 
    1310                 1315                 1320             


Asn Glu  Asp Gly Glu Leu Gly  Leu Ala Tyr Gln Gly  Leu Lys Gln 
    1325                 1330                 1335             


Val Ala  Arg Leu Leu Glu Ala  Gln Leu Gln Ala Gln  Ser Leu Glu 
    1340                 1345                 1350             


His Glu  Glu Glu Val Glu His  Leu Lys Ala Gln Leu  Glu Ala Leu 
    1355                 1360                 1365             


Lys Glu  Glu Met Asp Lys Gln  Gln Gln Thr Phe Cys  Gln Thr Leu 
    1370                 1375                 1380             


Leu Leu  Ser Pro Glu Ala Gln  Val Glu Phe Gly Val  Gln Gln Glu 
    1385                 1390                 1395             


Ile Ser  Arg Leu Thr Asn Glu  Asn Leu Asp Leu Lys  Glu Leu Val 
    1400                 1405                 1410             


Glu Lys  Leu Glu Lys Asn Glu  Arg Lys Leu Lys Lys  Gln Leu Lys 
    1415                 1420                 1425             


Ile Tyr  Met Lys Lys Ala Gln  Asp Leu Glu Ala Ala  Gln Ala Leu 
    1430                 1435                 1440             


Ala Gln  Ser Glu Arg Lys Arg  His Glu Leu Asn Arg  Gln Val Thr 
    1445                 1450                 1455             


Val Gln  Arg Lys Glu Lys Asp  Phe Gln Gly Met Leu  Glu Tyr His 
    1460                 1465                 1470             


Lys Glu  Asp Glu Ala Leu Leu  Ile Arg Asn Leu Val  Thr Asp Leu 
    1475                 1480                 1485             


Lys Pro  Gln Met Leu Ser Gly  Thr Val Pro Cys Leu  Pro Ala Tyr 
    1490                 1495                 1500             


Ile Leu  Tyr Met Cys Ile Arg  His Ala Asp Tyr Thr  Asn Asp Asp 
    1505                 1510                 1515             


Leu Lys  Val His Ser Leu Leu  Thr Ser Thr Ile Asn  Gly Ile Lys 
    1520                 1525                 1530             


Lys Val  Leu Lys Lys His Asn  Asp Asp Phe Glu Met  Thr Ser Phe 
    1535                 1540                 1545             


Trp Leu  Ser Asn Thr Cys Arg  Leu Leu His Cys Leu  Lys Gln Tyr 
    1550                 1555                 1560             


Ser Gly  Asp Glu Gly Phe Met  Thr Gln Asn Thr Ala  Lys Gln Asn 
    1565                 1570                 1575             


Glu His  Cys Leu Lys Asn Phe  Asp Leu Thr Glu Tyr  Arg Gln Val 
    1580                 1585                 1590             


Leu Ser  Asp Leu Ser Ile Gln  Ile Tyr Gln Gln Leu  Ile Lys Ile 
    1595                 1600                 1605             


Ala Glu  Gly Val Leu Gln Pro  Met Ile Val Ser Ala  Met Leu Glu 
    1610                 1615                 1620             


Asn Glu  Ser Ile Gln Gly Leu  Ser Gly Val Lys Pro  Thr Gly Tyr 
    1625                 1630                 1635             


Arg Lys  Arg Ser Ser Ser Met  Ala Asp Gly Asp Asn  Ser Tyr Cys 
    1640                 1645                 1650             


Leu Glu  Ala Ile Ile Arg Gln  Met Asn Ala Phe His  Thr Val Met 
    1655                 1660                 1665             


Cys Asp  Gln Gly Leu Asp Pro  Glu Ile Ile Leu Gln  Val Phe Lys 
    1670                 1675                 1680             


Gln Leu  Phe Tyr Met Ile Asn  Ala Val Thr Leu Asn  Asn Leu Leu 
    1685                 1690                 1695             


Leu Arg  Lys Asp Val Cys Ser  Trp Ser Thr Gly Met  Gln Leu Arg 
    1700                 1705                 1710             


Tyr Asn  Ile Ser Gln Leu Glu  Glu Trp Leu Arg Gly  Arg Asn Leu 
    1715                 1720                 1725             


His Gln  Ser Gly Ala Val Gln  Thr Met Glu Pro Leu  Ile Gln Ala 
    1730                 1735                 1740             


Ala Gln  Leu Leu Gln Leu Lys  Lys Lys Thr Gln Glu  Asp Ala Glu 
    1745                 1750                 1755             


Ala Ile  Cys Ser Leu Cys Thr  Ser Leu Ser Thr Gln  Gln Ile Val 
    1760                 1765                 1770             


Lys Ile  Leu Asn Leu Tyr Thr  Pro Leu Asn Glu Phe  Glu Glu Arg 
    1775                 1780                 1785             


Val Thr  Val Ala Phe Ile Arg  Thr Ile Gln Ala Gln  Leu Gln Glu 
    1790                 1795                 1800             


Arg Asn  Asp Pro Gln Gln Leu  Leu Leu Asp Ala Lys  His Met Phe 
    1805                 1810                 1815             


Pro Val  Leu Phe Pro Phe Asn  Pro Ser Ser Leu Thr  Met Asp Ser 
    1820                 1825                 1830             


Ile His  Ile Pro Ala Cys Leu  Asn Leu Glu Phe Leu  Asn Glu Val 
    1835                 1840                 1845             


<210>  29
<211>  5675
<212>  DNA
<213>  Homo sapiens

<400>  29
ccggcggcgt cccggggcca ggggggtgcg cctttctccg cgtcggggcg gcccggagcg       60

cggtggcgcg gcgcgggagg ggttttctgg tgcgtcctgg tccaccatgg ccaaaccaac      120

aagcaaagat tcaggcttga aggagaagtt taagattctg ttgggactgg gaacaccgag      180

gccaaatccc aggtctgcag agggtaaaca gacggagttt atcatcaccg cggaaatact      240

gagagaactg agcatggaat gtggcctcaa caatcgcatc cggatgatag ggcagatttg      300

tgaagtcgca aaaaccaaga aatttgaaga gcacgcagtg gaagcactct ggaaggcggt      360

cgcggatctg ttgcagccgg agcggccgct ggaggcccgg cacgcggtgc tggctctgct      420

gaaggccatc gtgcaggggc agggcgagcg tttgggggtc ctcagagccc tcttctttaa      480

ggtcatcaag gattaccctt ccaacgaaga ccttcacgaa aggctggagg ttttcaaggc      540

cctcacagac aatgggagac acatcaccta cttggaggaa gagctggctg actttgtcct      600

gcagtggatg gatgttggct tgtcctcgga attccttctg gtgctggtga acttggtcaa      660

attcaatagc tgttacctcg acgagtacat cgcaaggatg gttcagatga tctgtctgct      720

gtgcgtccgg accgcgtcct ctgtggacat agaggtctcc ctgcaggtgc tggacgccgt      780

ggtctgctac aactgcctgc cggctgagag cctcccgctg ttcatcgtta ccctctgtcg      840

caccatcaac gtcaaggagc tctgcgagcc ttgctggaag ctgatgcgga acctccttgg      900

cacccacctg ggccacagcg ccatctacaa catgtgccac ctcatggagg acagagccta      960

catggaggac gcgcccctgc tgagaggagc cgtgtttttt gtgggcatgg ctctctgggg     1020

agcccaccgg ctctattctc tcaggaactc gccgacatct gtgttgccat cattttacca     1080

ggccatggca tgtccgaacg aggtggtgtc ctatgagatc gtcctgtcca tcaccaggct     1140

catcaagaag tataggaagg agctccaggt ggtggcgtgg gacattctgc tgaacatcat     1200

cgaacggctc cttcagcagc tccagacctt ggacagcccg gagctcagga ccatcgtcca     1260

tgacctgttg accacggtgg aggagctgtg tgaccagaac gagttccacg ggtctcagga     1320

gagatacttt gaactggtgg agagatgtgc ggaccagagg cctgagtcct ccctcctgaa     1380

cctgatctcc tatagagcgc agtccatcca cccggccaag gacggctgga ttcagaacct     1440

gcaggcgctg atggagagat tcttcaggag cgagtcccga ggcgccgtgc gcatcaaggt     1500

gctggacgtg ctgtcctttg tgctgctcat caacaggcag ttctatgagg aggagctgat     1560

taactcagtg gtcatctcgc agctctccca catccccgag gataaagacc accaggtccg     1620

aaagctggcc acccagttgc tggtggacct ggcagagggc tgccacacac accacttcaa     1680

cagcctgctg gacatcatcg agaaggtgat ggcccgctcc ctctccccac ccccggagct     1740

ggaagaaagg gatgtggccg catactcggc ctccttggag gatgtgaaga cagccgtcct     1800

ggggcttctg gtcatccttc agaccaagct gtacaccctg cctgcaagcc acgccacgcg     1860

tgtgtatgag atgctggtca gccacattca gctccactac aagcacagct acaccctgcc     1920

aatcgcgagc agcatccggc tgcaggcctt tgacttcctg ttgctgctgc gggccgactc     1980

actgcaccgc ctgggcctgc ccaacaagga tggagtcgtg cggttcagcc cctactgcgt     2040

ctgcgactac atggagccag agagaggctc tgagaagaag accagcggcc ccctttctcc     2100

tcccacaggg cctcctggcc cggcgcctgc aggccccgcc gtgcggctgg ggtccgtgcc     2160

ctactccctg ctcttccgcg tcctgctgca gtgcttgaag caggagtctg actggaaggt     2220

gctgaagctg gttctgggca ggctgcctga gtccctgcgc tataaagtgc tcatctttac     2280

ttccccttgc agtgtggacc agctgtgctc tgctctctgc tccatgcttt caggcccaaa     2340

gacactggag cggctccgag gcgccccaga aggcttctcc agaactgact tgcacctggc     2400

cgtggttcca gtgctgacag cattaatctc ttaccataac tacctggaca aaaccaaaca     2460

gcgcgagatg gtctactgcc tggagcaggg cctcatccac cgctgtgcca gccagtgcgt     2520

cgtggccttg tccatctgca gcgtggagat gcctgacatc atcatcaagg cgctgcctgt     2580

tctggtggtg aagctcacgc acatctcagc cacagccagc atggccgtcc cactgctgga     2640

gttcctgtcc actctggcca ggctgccgca cctctacagg aactttgccg cggagcagta     2700

tgccagtgtg ttcgccatct ccctgccgta caccaacccc tccaagttta atcagtacat     2760

cgtgtgtctg gcccatcacg tcatagccat gtggttcatc aggtgccgcc tgcccttccg     2820

gaaggatttt gtccctttca tcactaaggg cctgcggtcc aatgtcctct tgtcttttga     2880

tgacaccccc gagaaggaca gcttcagggc ccggagtact agtctcaacg agagacccaa     2940

gagtctgagg atagccagac cccccaaaca aggcttgaat aactctccac ccgtgaaaga     3000

attcaaggag agctctgcag ccgaggcctt ccggtgccgc agcatcagtg tgtctgaaca     3060

tgtggtccgc agcaggatac agacgtccct caccagtgcc agcttggggt ctgcagatga     3120

gaactccgtg gcccaggctg acgatagcct gaaaaacctc cacctggagc tcacggaaac     3180

ctgtctggac atgatggctc gatacgtctt ctccaacttc acggctgtcc cgaagaggtc     3240

tcctgtgggc gagttcctcc tagcgggtgg caggaccaaa acctggctgg ttgggaacaa     3300

gcttgtcact gtgacgacaa gcgtgggaac cgggacccgg tcgttactag gcctggactc     3360

gggggagctg cagtccggcc cggagtcgag ctccagcccc ggggtgcatg tgagacagac     3420

caaggaggcg ccggccaagc tggagtccca ggctgggcag caggtgtccc gtggggcccg     3480

ggatcgggtc cgttccatgt cggggggcca tggtcttcga gttggcgccc tggacgtgcc     3540

ggcctcccag ttcctgggca gtgccacttc tccaggacca cggactgcac cagccgcgaa     3600

acctgagaag gcctcagctg gcacccgggt tcctgtgcag gagaagacga acctggcggc     3660

ctatgtgccc ctgctgaccc agggctgggc ggagatcctg gtccggaggc ccacagggaa     3720

caccagctgg ctgatgagcc tggagaaccc gctcagccct ttctcctcgg acatcaacaa     3780

catgcccctg caggagctgt ctaacgccct catggcggct gagcgcttca aggagcaccg     3840

ggacacagcc ctgtacaagt cactgtcggt gccggcagcc agcacggcca aaccccctcc     3900

tctgcctcgc tccaacacag tggcctcttt ctcctccctg taccagtcca gctgccaagg     3960

acagctgcac aggagcgttt cctgggcaga ctccgccgtg gtcatggagg agggaagtcc     4020

gggcgaggtt cctgtgctgg tggagccccc agggttggag gacgttgagg cagcgctagg     4080

catggacagg cgcacggatg cctacagcag gtcgtcctca gtctccagcc aggaggagaa     4140

gtcgctccac gcggaggagc tggttggcag gggcatcccc atcgagcgag tcgtctcctc     4200

ggagggtggc cggccctctg tggacctctc cttccagccc tcgcagcccc tgagcaagtc     4260

cagctcctct cccgagctgc agactctgca ggacatcctc ggggaccctg gggacaaggc     4320

cgacgtgggc cggctgagcc ctgaggttaa ggcccggtca cagtcaggga ccctggacgg     4380

ggaaagtgct gcctggtcgg cctcgggcga agacagtcgg ggccagcccg agggtccctt     4440

gccttccagc tccccccgct cgcccagtgg cctccggccc cgaggttaca ccatctccga     4500

ctcggcccca tcacgcaggg gcaagagagt agagagggac gccttaaaga gcagagccac     4560

agcctccaat gcagagaaag tgccaggcat caaccccagt ttcgtgttcc tgcagctcta     4620

ccattccccc ttctttggcg acgagtcaaa caagccaatc ctgctgccca atgagtcaca     4680

gtcctttgag cggtcggtgc agctcctcga ccagatccca tcatacgaca cccacaagat     4740

cgccgtcctg tatgttggag aaggccagag caacagcgag ctcgccatcc tgtccaatga     4800

gcatggctcc tacaggtaca cggagttcct gacgggcctg ggccggctca tcgagctgaa     4860

ggactgccag ccggacaagg tgtacctggg aggcctggac gtgtgtggtg aggacggcca     4920

gttcacctac tgctggcacg atgacatcat gcaagccgtc ttccacatcg ccaccctgat     4980

gcccaccaag gacgtggaca agcaccgctg cgacaagaag cgccacctgg gcaacgactt     5040

tgtgtccatt gtctacaatg actccggtga ggacttcaag cttggcacca tcaagggcca     5100

gttcaacttt gtccacgtga tcgtcacccc gctggactac gagtgcaacc tggtgtccct     5160

gcagtgcagg aaagacatgg agggccttgt ggacaccagc gtggccaaga tcgtgtctga     5220

ccgcaacctg cccttcgtgg cccgccagat ggccctgcac gcaaatatgg cctcacaggt     5280

gcatcatagc cgctccaacc ccaccgatat ctacccctcc aagtggattg cccggctccg     5340

ccacatcaag cggctccgcc agcggatctg cgaggaagcc gcctactcca accccagcct     5400

acctctggtg caccctccgt cccatagcaa agcccctgca cagactccag ccgagcccac     5460

acctggctat gaggtgggcc agcggaagcg cctcatctcc tcggtggagg acttcaccga     5520

gtttgtgtga ggccggggcc ctccctcctg cactggcctt ggacggtatt gcctgtcagt     5580

gaaataaata aagtcctgac cccagtgcac agacatagag gcacagattg caaaaaaaaa     5640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                5675


<210>  30
<211>  1807
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Ser Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser 
945                 950                 955                 960 


Pro Pro Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg 
                965                 970                 975     


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            980                 985                 990         


Thr Ser Leu Thr Ser Ala Ser Leu  Gly Ser Ala Asp Glu  Asn Ser Val 
        995                 1000                 1005             


Ala Gln  Ala Asp Asp Ser Leu  Lys Asn Leu His Leu  Glu Leu Thr 
    1010                 1015                 1020             


Glu Thr  Cys Leu Asp Met Met  Ala Arg Tyr Val Phe  Ser Asn Phe 
    1025                 1030                 1035             


Thr Ala  Val Pro Lys Arg Ser  Pro Val Gly Glu Phe  Leu Leu Ala 
    1040                 1045                 1050             


Gly Gly  Arg Thr Lys Thr Trp  Leu Val Gly Asn Lys  Leu Val Thr 
    1055                 1060                 1065             


Val Thr  Thr Ser Val Gly Thr  Gly Thr Arg Ser Leu  Leu Gly Leu 
    1070                 1075                 1080             


Asp Ser  Gly Glu Leu Gln Ser  Gly Pro Glu Ser Ser  Ser Ser Pro 
    1085                 1090                 1095             


Gly Val  His Val Arg Gln Thr  Lys Glu Ala Pro Ala  Lys Leu Glu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Gln Gln Val  Ser Arg Gly Ala Arg  Asp Arg Val 
    1115                 1120                 1125             


Arg Ser  Met Ser Gly Gly His  Gly Leu Arg Val Gly  Ala Leu Asp 
    1130                 1135                 1140             


Val Pro  Ala Ser Gln Phe Leu  Gly Ser Ala Thr Ser  Pro Gly Pro 
    1145                 1150                 1155             


Arg Thr  Ala Pro Ala Ala Lys  Pro Glu Lys Ala Ser  Ala Gly Thr 
    1160                 1165                 1170             


Arg Val  Pro Val Gln Glu Lys  Thr Asn Leu Ala Ala  Tyr Val Pro 
    1175                 1180                 1185             


Leu Leu  Thr Gln Gly Trp Ala  Glu Ile Leu Val Arg  Arg Pro Thr 
    1190                 1195                 1200             


Gly Asn  Thr Ser Trp Leu Met  Ser Leu Glu Asn Pro  Leu Ser Pro 
    1205                 1210                 1215             


Phe Ser  Ser Asp Ile Asn Asn  Met Pro Leu Gln Glu  Leu Ser Asn 
    1220                 1225                 1230             


Ala Leu  Met Ala Ala Glu Arg  Phe Lys Glu His Arg  Asp Thr Ala 
    1235                 1240                 1245             


Leu Tyr  Lys Ser Leu Ser Val  Pro Ala Ala Ser Thr  Ala Lys Pro 
    1250                 1255                 1260             


Pro Pro  Leu Pro Arg Ser Asn  Thr Val Ala Ser Phe  Ser Ser Leu 
    1265                 1270                 1275             


Tyr Gln  Ser Ser Cys Gln Gly  Gln Leu His Arg Ser  Val Ser Trp 
    1280                 1285                 1290             


Ala Asp  Ser Ala Val Val Met  Glu Glu Gly Ser Pro  Gly Glu Val 
    1295                 1300                 1305             


Pro Val  Leu Val Glu Pro Pro  Gly Leu Glu Asp Val  Glu Ala Ala 
    1310                 1315                 1320             


Leu Gly  Met Asp Arg Arg Thr  Asp Ala Tyr Ser Arg  Ser Ser Ser 
    1325                 1330                 1335             


Val Ser  Ser Gln Glu Glu Lys  Ser Leu His Ala Glu  Glu Leu Val 
    1340                 1345                 1350             


Gly Arg  Gly Ile Pro Ile Glu  Arg Val Val Ser Ser  Glu Gly Gly 
    1355                 1360                 1365             


Arg Pro  Ser Val Asp Leu Ser  Phe Gln Pro Ser Gln  Pro Leu Ser 
    1370                 1375                 1380             


Lys Ser  Ser Ser Ser Pro Glu  Leu Gln Thr Leu Gln  Asp Ile Leu 
    1385                 1390                 1395             


Gly Asp  Pro Gly Asp Lys Ala  Asp Val Gly Arg Leu  Ser Pro Glu 
    1400                 1405                 1410             


Val Lys  Ala Arg Ser Gln Ser  Gly Thr Leu Asp Gly  Glu Ser Ala 
    1415                 1420                 1425             


Ala Trp  Ser Ala Ser Gly Glu  Asp Ser Arg Gly Gln  Pro Glu Gly 
    1430                 1435                 1440             


Pro Leu  Pro Ser Ser Ser Pro  Arg Ser Pro Ser Gly  Leu Arg Pro 
    1445                 1450                 1455             


Arg Gly  Tyr Thr Ile Ser Asp  Ser Ala Pro Ser Arg  Arg Gly Lys 
    1460                 1465                 1470             


Arg Val  Glu Arg Asp Ala Leu  Lys Ser Arg Ala Thr  Ala Ser Asn 
    1475                 1480                 1485             


Ala Glu  Lys Val Pro Gly Ile  Asn Pro Ser Phe Val  Phe Leu Gln 
    1490                 1495                 1500             


Leu Tyr  His Ser Pro Phe Phe  Gly Asp Glu Ser Asn  Lys Pro Ile 
    1505                 1510                 1515             


Leu Leu  Pro Asn Glu Ser Gln  Ser Phe Glu Arg Ser  Val Gln Leu 
    1520                 1525                 1530             


Leu Asp  Gln Ile Pro Ser Tyr  Asp Thr His Lys Ile  Ala Val Leu 
    1535                 1540                 1545             


Tyr Val  Gly Glu Gly Gln Ser  Asn Ser Glu Leu Ala  Ile Leu Ser 
    1550                 1555                 1560             


Asn Glu  His Gly Ser Tyr Arg  Tyr Thr Glu Phe Leu  Thr Gly Leu 
    1565                 1570                 1575             


Gly Arg  Leu Ile Glu Leu Lys  Asp Cys Gln Pro Asp  Lys Val Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Leu Asp Val Cys  Gly Glu Asp Gly Gln  Phe Thr Tyr 
    1595                 1600                 1605             


Cys Trp  His Asp Asp Ile Met  Gln Ala Val Phe His  Ile Ala Thr 
    1610                 1615                 1620             


Leu Met  Pro Thr Lys Asp Val  Asp Lys His Arg Cys  Asp Lys Lys 
    1625                 1630                 1635             


Arg His  Leu Gly Asn Asp Phe  Val Ser Ile Val Tyr  Asn Asp Ser 
    1640                 1645                 1650             


Gly Glu  Asp Phe Lys Leu Gly  Thr Ile Lys Gly Gln  Phe Asn Phe 
    1655                 1660                 1665             


Val His  Val Ile Val Thr Pro  Leu Asp Tyr Glu Cys  Asn Leu Val 
    1670                 1675                 1680             


Ser Leu  Gln Cys Arg Lys Asp  Met Glu Gly Leu Val  Asp Thr Ser 
    1685                 1690                 1695             


Val Ala  Lys Ile Val Ser Asp  Arg Asn Leu Pro Phe  Val Ala Arg 
    1700                 1705                 1710             


Gln Met  Ala Leu His Ala Asn  Met Ala Ser Gln Val  His His Ser 
    1715                 1720                 1725             


Arg Ser  Asn Pro Thr Asp Ile  Tyr Pro Ser Lys Trp  Ile Ala Arg 
    1730                 1735                 1740             


Leu Arg  His Ile Lys Arg Leu  Arg Gln Arg Ile Cys  Glu Glu Ala 
    1745                 1750                 1755             


Ala Tyr  Ser Asn Pro Ser Leu  Pro Leu Val His Pro  Pro Ser His 
    1760                 1765                 1770             


Ser Lys  Ala Pro Ala Gln Thr  Pro Ala Glu Pro Thr  Pro Gly Tyr 
    1775                 1780                 1785             


Glu Val  Gly Gln Arg Lys Arg  Leu Ile Ser Ser Val  Glu Asp Phe 
    1790                 1795                 1800             


Thr Glu  Phe Val 
    1805         


<210>  31
<211>  5474
<212>  DNA
<213>  Homo sapiens

<400>  31
ccggcggcgt cccggggcca ggggggtgcg cctttctccg cgtcggggcg gcccggagcg       60

cggtggcgcg gcgcgggagg ggttttctgg tgcgtcctgg tccaccatgg ccaaaccaac      120

aagcaaagat tcaggcttga aggagaagtt taagattctg ttgggactgg gaacaccgag      180

gccaaatccc aggtctgcag agggtaaaca gacggagttt atcatcaccg cggaaatact      240

gagagaactg agcatggaat gtggcctcaa caatcgcatc cggatgatag ggcagatttg      300

tgaagtcgca aaaaccaaga aatttgaaga gcacgcagtg gaagcactct ggaaggcggt      360

cgcggatctg ttgcagccgg agcggccgct ggaggcccgg cacgcggtgc tggctctgct      420

gaaggccatc gtgcaggggc agggcgagcg tttgggggtc ctcagagccc tcttctttaa      480

ggtcatcaag gattaccctt ccaacgaaga ccttcacgaa aggctggagg ttttcaaggc      540

cctcacagac aatgggagac acatcaccta cttggaggaa gagctggctg actttgtcct      600

gcagtggatg gatgttggct tgtcctcgga attccttctg gtgctggtga acttggtcaa      660

attcaatagc tgttacctcg acgagtacat cgcaaggatg gttcagatga tctgtctgct      720

gtgcgtccgg accgcgtcct ctgtggacat agaggtctcc ctgcaggtgc tggacgccgt      780

ggtctgctac aactgcctgc cggctgagag cctcccgctg ttcatcgtta ccctctgtcg      840

caccatcaac gtcaaggagc tctgcgagcc ttgctggaag ctgatgcgga acctccttgg      900

cacccacctg ggccacagcg ccatctacaa catgtgccac ctcatggagg acagagccta      960

catggaggac gcgcccctgc tgagaggagc cgtgtttttt gtgggcatgg ctctctgggg     1020

agcccaccgg ctctattctc tcaggaactc gccgacatct gtgttgccat cattttacca     1080

ggccatggca tgtccgaacg aggtggtgtc ctatgagatc gtcctgtcca tcaccaggct     1140

catcaagaag tataggaagg agctccaggt ggtggcgtgg gacattctgc tgaacatcat     1200

cgaacggctc cttcagcagc tccagacctt ggacagcccg gagctcagga ccatcgtcca     1260

tgacctgttg accacggtgg aggagctgtg tgaccagaac gagttccacg ggtctcagga     1320

gagatacttt gaactggtgg agagatgtgc ggaccagagg cctgagtcct ccctcctgaa     1380

cctgatctcc tatagagcgc agtccatcca cccggccaag gacggctgga ttcagaacct     1440

gcaggcgctg atggagagat tcttcaggag cgagtcccga ggcgccgtgc gcatcaaggt     1500

gctggacgtg ctgtcctttg tgctgctcat caacaggcag ttctatgagg aggagctgat     1560

taactcagtg gtcatctcgc agctctccca catccccgag gataaagacc accaggtccg     1620

aaagctggcc acccagttgc tggtggacct ggcagagggc tgccacacac accacttcaa     1680

cagcctgctg gacatcatcg agaaggtgat ggcccgctcc ctctccccac ccccggagct     1740

ggaagaaagg gatgtggccg catactcggc ctccttggag gatgtgaaga cagccgtcct     1800

ggggcttctg gtcatccttc agaccaagct gtacaccctg cctgcaagcc acgccacgcg     1860

tgtgtatgag atgctggtca gccacattca gctccactac aagcacagct acaccctgcc     1920

aatcgcgagc agcatccggc tgcaggcctt tgacttcctg ttgctgctgc gggccgactc     1980

actgcaccgc ctgggcctgc ccaacaagga tggagtcgtg cggttcagcc cctactgcgt     2040

ctgcgactac atggagccag agagaggctc tgagaagaag accagcggcc ccctttctcc     2100

tcccacaggg cctcctggcc cggcgcctgc aggccccgcc gtgcggctgg ggtccgtgcc     2160

ctactccctg ctcttccgcg tcctgctgca gtgcttgaag caggagtctg actggaaggt     2220

gctgaagctg gttctgggca ggctgcctga gtccctgcgc tataaagtgc tcatctttac     2280

ttccccttgc agtgtggacc agctgtgctc tgctctctgc tccatgcttt caggcccaaa     2340

gacactggag cggctccgag gcgccccaga aggcttctcc agaactgact tgcacctggc     2400

cgtggttcca gtgctgacag cattaatctc ttaccataac tacctggaca aaaccaaaca     2460

gcgcgagatg gtctactgcc tggagcaggg cctcatccac cgctgtgcca gccagtgcgt     2520

cgtggccttg tccatctgca gcgtggagat gcctgacatc atcatcaagg cgctgcctgt     2580

tctggtggtg aagctcacgc acatctcagc cacagccagc atggccgtcc cactgctgga     2640

gttcctgtcc actctggcca ggctgccgca cctctacagg aactttgccg cggagcagta     2700

tgccagtgtg ttcgccatct ccctgccgta caccaacccc tccaagttta atcagtacat     2760

cgtgtgtctg gcccatcacg tcatagccat gtggttcatc aggtgccgcc tgcccttccg     2820

gaaggatttt gtccctttca tcactaaggg cctgcggtcc aatgtcctct tgtcttttga     2880

tgacaccccc gagaaggaca gcttcagggc ccggagtact agtctcaacg agagacccaa     2940

gaggatacag acgtccctca ccagtgccag cttggggtct gcagatgaga actccgtggc     3000

ccaggctgac gatagcctga aaaacctcca cctggagctc acggaaacct gtctggacat     3060

gatggctcga tacgtcttct ccaacttcac ggctgtcccg aagaggtctc ctgtgggcga     3120

gttcctccta gcgggtggca ggaccaaaac ctggctggtt gggaacaagc ttgtcactgt     3180

gacgacaagc gtgggaaccg ggacccggtc gttactaggc ctggactcgg gggagctgca     3240

gtccggcccg gagtcgagct ccagccccgg ggtgcatgtg agacagacca aggaggcgcc     3300

ggccaagctg gagtcccagg ctgggcagca ggtgtcccgt ggggcccggg atcgggtccg     3360

ttccatgtcg gggggccatg gtcttcgagt tggcgccctg gacgtgccgg cctcccagtt     3420

cctgggcagt gccacttctc caggaccacg gactgcacca gccgcgaaac ctgagaaggc     3480

ctcagctggc acccgggttc ctgtgcagga gaagacgaac ctggcggcct atgtgcccct     3540

gctgacccag ggctgggcgg agatcctggt ccggaggccc acagggaaca ccagctggct     3600

gatgagcctg gagaacccgc tcagcccttt ctcctcggac atcaacaaca tgcccctgca     3660

ggagctgtct aacgccctca tggcggctga gcgcttcaag gagcaccggg acacagccct     3720

gtacaagtca ctgtcggtgc cggcagccag cacggccaaa ccccctcctc tgcctcgctc     3780

caacacagac tccgccgtgg tcatggagga gggaagtccg ggcgaggttc ctgtgctggt     3840

ggagccccca gggttggagg acgttgaggc agcgctaggc atggacaggc gcacggatgc     3900

ctacagcagg tcgtcctcag tctccagcca ggaggagaag tcgctccacg cggaggagct     3960

ggttggcagg ggcatcccca tcgagcgagt cgtctcctcg gagggtggcc ggccctctgt     4020

ggacctctcc ttccagccct cgcagcccct gagcaagtcc agctcctctc ccgagctgca     4080

gactctgcag gacatcctcg gggaccctgg ggacaaggcc gacgtgggcc ggctgagccc     4140

tgaggttaag gcccggtcac agtcagggac cctggacggg gaaagtgctg cctggtcggc     4200

ctcgggcgaa gacagtcggg gccagcccga gggtcccttg ccttccagct ccccccgctc     4260

gcccagtggc ctccggcccc gaggttacac catctccgac tcggccccat cacgcagggg     4320

caagagagta gagagggacg ccttaaagag cagagccaca gcctccaatg cagagaaagt     4380

gccaggcatc aaccccagtt tcgtgttcct gcagctctac cattccccct tctttggcga     4440

cgagtcaaac aagccaatcc tgctgcccaa tgagtcacag tcctttgagc ggtcggtgca     4500

gctcctcgac cagatcccat catacgacac ccacaagatc gccgtcctgt atgttggaga     4560

aggccagagc aacagcgagc tcgccatcct gtccaatgag catggctcct acaggtacac     4620

ggagttcctg acgggcctgg gccggctcat cgagctgaag gactgccagc cggacaaggt     4680

gtacctggga ggcctggacg tgtgtggtga ggacggccag ttcacctact gctggcacga     4740

tgacatcatg caagccgtct tccacatcgc caccctgatg cccaccaagg acgtggacaa     4800

gcaccgctgc gacaagaagc gccacctggg caacgacttt gtgtccattg tctacaatga     4860

ctccggtgag gacttcaagc ttggcaccat caagggccag ttcaactttg tccacgtgat     4920

cgtcaccccg ctggactacg agtgcaacct ggtgtccctg cagtgcagga aagacatgga     4980

gggccttgtg gacaccagcg tggccaagat cgtgtctgac cgcaacctgc ccttcgtggc     5040

ccgccagatg gccctgcacg caaatatggc ctcacaggtg catcatagcc gctccaaccc     5100

caccgatatc tacccctcca agtggattgc ccggctccgc cacatcaagc ggctccgcca     5160

gcggatctgc gaggaagccg cctactccaa ccccagccta cctctggtgc accctccgtc     5220

ccatagcaaa gcccctgcac agactccagc cgagcccaca cctggctatg aggtgggcca     5280

gcggaagcgc ctcatctcct cggtggagga cttcaccgag tttgtgtgag gccggggccc     5340

tccctcctgc actggccttg gacggtattg cctgtcagtg aaataaataa agtcctgacc     5400

ccagtgcaca gacatagagg cacagattgc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5460

aaaaaaaaaa aaaa                                                       5474


<210>  32
<211>  1740
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Arg Ile Gln Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp 
945                 950                 955                 960 


Glu Asn Ser Val Ala Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu 
                965                 970                 975     


Glu Leu Thr Glu Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser 
            980                 985                 990         


Asn Phe Thr Ala Val Pro Lys Arg  Ser Pro Val Gly Glu  Phe Leu Leu 
        995                 1000                 1005             


Ala Gly  Gly Arg Thr Lys Thr  Trp Leu Val Gly Asn  Lys Leu Val 
    1010                 1015                 1020             


Thr Val  Thr Thr Ser Val Gly  Thr Gly Thr Arg Ser  Leu Leu Gly 
    1025                 1030                 1035             


Leu Asp  Ser Gly Glu Leu Gln  Ser Gly Pro Glu Ser  Ser Ser Ser 
    1040                 1045                 1050             


Pro Gly  Val His Val Arg Gln  Thr Lys Glu Ala Pro  Ala Lys Leu 
    1055                 1060                 1065             


Glu Ser  Gln Ala Gly Gln Gln  Val Ser Arg Gly Ala  Arg Asp Arg 
    1070                 1075                 1080             


Val Arg  Ser Met Ser Gly Gly  His Gly Leu Arg Val  Gly Ala Leu 
    1085                 1090                 1095             


Asp Val  Pro Ala Ser Gln Phe  Leu Gly Ser Ala Thr  Ser Pro Gly 
    1100                 1105                 1110             


Pro Arg  Thr Ala Pro Ala Ala  Lys Pro Glu Lys Ala  Ser Ala Gly 
    1115                 1120                 1125             


Thr Arg  Val Pro Val Gln Glu  Lys Thr Asn Leu Ala  Ala Tyr Val 
    1130                 1135                 1140             


Pro Leu  Leu Thr Gln Gly Trp  Ala Glu Ile Leu Val  Arg Arg Pro 
    1145                 1150                 1155             


Thr Gly  Asn Thr Ser Trp Leu  Met Ser Leu Glu Asn  Pro Leu Ser 
    1160                 1165                 1170             


Pro Phe  Ser Ser Asp Ile Asn  Asn Met Pro Leu Gln  Glu Leu Ser 
    1175                 1180                 1185             


Asn Ala  Leu Met Ala Ala Glu  Arg Phe Lys Glu His  Arg Asp Thr 
    1190                 1195                 1200             


Ala Leu  Tyr Lys Ser Leu Ser  Val Pro Ala Ala Ser  Thr Ala Lys 
    1205                 1210                 1215             


Pro Pro  Pro Leu Pro Arg Ser  Asn Thr Asp Ser Ala  Val Val Met 
    1220                 1225                 1230             


Glu Glu  Gly Ser Pro Gly Glu  Val Pro Val Leu Val  Glu Pro Pro 
    1235                 1240                 1245             


Gly Leu  Glu Asp Val Glu Ala  Ala Leu Gly Met Asp  Arg Arg Thr 
    1250                 1255                 1260             


Asp Ala  Tyr Ser Arg Ser Ser  Ser Val Ser Ser Gln  Glu Glu Lys 
    1265                 1270                 1275             


Ser Leu  His Ala Glu Glu Leu  Val Gly Arg Gly Ile  Pro Ile Glu 
    1280                 1285                 1290             


Arg Val  Val Ser Ser Glu Gly  Gly Arg Pro Ser Val  Asp Leu Ser 
    1295                 1300                 1305             


Phe Gln  Pro Ser Gln Pro Leu  Ser Lys Ser Ser Ser  Ser Pro Glu 
    1310                 1315                 1320             


Leu Gln  Thr Leu Gln Asp Ile  Leu Gly Asp Pro Gly  Asp Lys Ala 
    1325                 1330                 1335             


Asp Val  Gly Arg Leu Ser Pro  Glu Val Lys Ala Arg  Ser Gln Ser 
    1340                 1345                 1350             


Gly Thr  Leu Asp Gly Glu Ser  Ala Ala Trp Ser Ala  Ser Gly Glu 
    1355                 1360                 1365             


Asp Ser  Arg Gly Gln Pro Glu  Gly Pro Leu Pro Ser  Ser Ser Pro 
    1370                 1375                 1380             


Arg Ser  Pro Ser Gly Leu Arg  Pro Arg Gly Tyr Thr  Ile Ser Asp 
    1385                 1390                 1395             


Ser Ala  Pro Ser Arg Arg Gly  Lys Arg Val Glu Arg  Asp Ala Leu 
    1400                 1405                 1410             


Lys Ser  Arg Ala Thr Ala Ser  Asn Ala Glu Lys Val  Pro Gly Ile 
    1415                 1420                 1425             


Asn Pro  Ser Phe Val Phe Leu  Gln Leu Tyr His Ser  Pro Phe Phe 
    1430                 1435                 1440             


Gly Asp  Glu Ser Asn Lys Pro  Ile Leu Leu Pro Asn  Glu Ser Gln 
    1445                 1450                 1455             


Ser Phe  Glu Arg Ser Val Gln  Leu Leu Asp Gln Ile  Pro Ser Tyr 
    1460                 1465                 1470             


Asp Thr  His Lys Ile Ala Val  Leu Tyr Val Gly Glu  Gly Gln Ser 
    1475                 1480                 1485             


Asn Ser  Glu Leu Ala Ile Leu  Ser Asn Glu His Gly  Ser Tyr Arg 
    1490                 1495                 1500             


Tyr Thr  Glu Phe Leu Thr Gly  Leu Gly Arg Leu Ile  Glu Leu Lys 
    1505                 1510                 1515             


Asp Cys  Gln Pro Asp Lys Val  Tyr Leu Gly Gly Leu  Asp Val Cys 
    1520                 1525                 1530             


Gly Glu  Asp Gly Gln Phe Thr  Tyr Cys Trp His Asp  Asp Ile Met 
    1535                 1540                 1545             


Gln Ala  Val Phe His Ile Ala  Thr Leu Met Pro Thr  Lys Asp Val 
    1550                 1555                 1560             


Asp Lys  His Arg Cys Asp Lys  Lys Arg His Leu Gly  Asn Asp Phe 
    1565                 1570                 1575             


Val Ser  Ile Val Tyr Asn Asp  Ser Gly Glu Asp Phe  Lys Leu Gly 
    1580                 1585                 1590             


Thr Ile  Lys Gly Gln Phe Asn  Phe Val His Val Ile  Val Thr Pro 
    1595                 1600                 1605             


Leu Asp  Tyr Glu Cys Asn Leu  Val Ser Leu Gln Cys  Arg Lys Asp 
    1610                 1615                 1620             


Met Glu  Gly Leu Val Asp Thr  Ser Val Ala Lys Ile  Val Ser Asp 
    1625                 1630                 1635             


Arg Asn  Leu Pro Phe Val Ala  Arg Gln Met Ala Leu  His Ala Asn 
    1640                 1645                 1650             


Met Ala  Ser Gln Val His His  Ser Arg Ser Asn Pro  Thr Asp Ile 
    1655                 1660                 1665             


Tyr Pro  Ser Lys Trp Ile Ala  Arg Leu Arg His Ile  Lys Arg Leu 
    1670                 1675                 1680             


Arg Gln  Arg Ile Cys Glu Glu  Ala Ala Tyr Ser Asn  Pro Ser Leu 
    1685                 1690                 1695             


Pro Leu  Val His Pro Pro Ser  His Ser Lys Ala Pro  Ala Gln Thr 
    1700                 1705                 1710             


Pro Ala  Glu Pro Thr Pro Gly  Tyr Glu Val Gly Gln  Arg Lys Arg 
    1715                 1720                 1725             


Leu Ile  Ser Ser Val Glu Asp  Phe Thr Glu Phe Val  
    1730                 1735                 1740 


<210>  33
<211>  5577
<212>  DNA
<213>  Homo sapiens

<400>  33
ccggcggcgt cccggggcca ggggggtgcg cctttctccg cgtcggggcg gcccggagcg       60

cggtggcgcg gcgcgggagg ggttttctgg tgcgtcctgg tccaccatgg ccaaaccaac      120

aagcaaagat tcaggcttga aggagaagtt taagattctg ttgggactgg gaacaccgag      180

gccaaatccc aggtctgcag agggtaaaca gacggagttt atcatcaccg cggaaatact      240

gagagaactg agcatggaat gtggcctcaa caatcgcatc cggatgatag ggcagatttg      300

tgaagtcgca aaaaccaaga aatttgaaga gcacgcagtg gaagcactct ggaaggcggt      360

cgcggatctg ttgcagccgg agcggccgct ggaggcccgg cacgcggtgc tggctctgct      420

gaaggccatc gtgcaggggc agggcgagcg tttgggggtc ctcagagccc tcttctttaa      480

ggtcatcaag gattaccctt ccaacgaaga ccttcacgaa aggctggagg ttttcaaggc      540

cctcacagac aatgggagac acatcaccta cttggaggaa gagctggctg actttgtcct      600

gcagtggatg gatgttggct tgtcctcgga attccttctg gtgctggtga acttggtcaa      660

attcaatagc tgttacctcg acgagtacat cgcaaggatg gttcagatga tctgtctgct      720

gtgcgtccgg accgcgtcct ctgtggacat agaggtctcc ctgcaggtgc tggacgccgt      780

ggtctgctac aactgcctgc cggctgagag cctcccgctg ttcatcgtta ccctctgtcg      840

caccatcaac gtcaaggagc tctgcgagcc ttgctggaag ctgatgcgga acctccttgg      900

cacccacctg ggccacagcg ccatctacaa catgtgccac ctcatggagg acagagccta      960

catggaggac gcgcccctgc tgagaggagc cgtgtttttt gtgggcatgg ctctctgggg     1020

agcccaccgg ctctattctc tcaggaactc gccgacatct gtgttgccat cattttacca     1080

ggccatggca tgtccgaacg aggtggtgtc ctatgagatc gtcctgtcca tcaccaggct     1140

catcaagaag tataggaagg agctccaggt ggtggcgtgg gacattctgc tgaacatcat     1200

cgaacggctc cttcagcagc tccagacctt ggacagcccg gagctcagga ccatcgtcca     1260

tgacctgttg accacggtgg aggagctgtg tgaccagaac gagttccacg ggtctcagga     1320

gagatacttt gaactggtgg agagatgtgc ggaccagagg cctgagtcct ccctcctgaa     1380

cctgatctcc tatagagcgc agtccatcca cccggccaag gacggctgga ttcagaacct     1440

gcaggcgctg atggagagat tcttcaggag cgagtcccga ggcgccgtgc gcatcaaggt     1500

gctggacgtg ctgtcctttg tgctgctcat caacaggcag ttctatgagg aggagctgat     1560

taactcagtg gtcatctcgc agctctccca catccccgag gataaagacc accaggtccg     1620

aaagctggcc acccagttgc tggtggacct ggcagagggc tgccacacac accacttcaa     1680

cagcctgctg gacatcatcg agaaggtgat ggcccgctcc ctctccccac ccccggagct     1740

ggaagaaagg gatgtggccg catactcggc ctccttggag gatgtgaaga cagccgtcct     1800

ggggcttctg gtcatccttc agaccaagct gtacaccctg cctgcaagcc acgccacgcg     1860

tgtgtatgag atgctggtca gccacattca gctccactac aagcacagct acaccctgcc     1920

aatcgcgagc agcatccggc tgcaggcctt tgacttcctg ttgctgctgc gggccgactc     1980

actgcaccgc ctgggcctgc ccaacaagga tggagtcgtg cggttcagcc cctactgcgt     2040

ctgcgactac atggagccag agagaggctc tgagaagaag accagcggcc ccctttctcc     2100

tcccacaggg cctcctggcc cggcgcctgc aggccccgcc gtgcggctgg ggtccgtgcc     2160

ctactccctg ctcttccgcg tcctgctgca gtgcttgaag caggagtctg actggaaggt     2220

gctgaagctg gttctgggca ggctgcctga gtccctgcgc tataaagtgc tcatctttac     2280

ttccccttgc agtgtggacc agctgtgctc tgctctctgc tccatgcttt caggcccaaa     2340

gacactggag cggctccgag gcgccccaga aggcttctcc agaactgact tgcacctggc     2400

cgtggttcca gtgctgacag cattaatctc ttaccataac tacctggaca aaaccaaaca     2460

gcgcgagatg gtctactgcc tggagcaggg cctcatccac cgctgtgcca gccagtgcgt     2520

cgtggccttg tccatctgca gcgtggagat gcctgacatc atcatcaagg cgctgcctgt     2580

tctggtggtg aagctcacgc acatctcagc cacagccagc atggccgtcc cactgctgga     2640

gttcctgtcc actctggcca ggctgccgca cctctacagg aactttgccg cggagcagta     2700

tgccagtgtg ttcgccatct ccctgccgta caccaacccc tccaagttta atcagtacat     2760

cgtgtgtctg gcccatcacg tcatagccat gtggttcatc aggtgccgcc tgcccttccg     2820

gaaggatttt gtccctttca tcactaaggg cctgcggtcc aatgtcctct tgtcttttga     2880

tgacaccccc gagaaggaca gcttcagggc ccggagtact agtctcaacg agagacccaa     2940

gagtctgagg atagccagac cccccaaaca aggcttgaat aactctccac ccgtgaaaga     3000

attcaaggag agctctgcag ccgaggcctt ccggtgccgc agcatcagtg tgtctgaaca     3060

tgtggtccgc agcaggatac agacgtccct caccagtgcc agcttggggt ctgcagatga     3120

gaactccgtg gcccaggctg acgatagcct gaaaaacctc cacctggagc tcacggaaac     3180

ctgtctggac atgatggctc gatacgtctt ctccaacttc acggctgtcc cgaagaggtc     3240

tcctgtgggc gagttcctcc tagcgggtgg caggaccaaa acctggctgg ttgggaacaa     3300

gcttgtcact gtgacgacaa gcgtgggaac cgggacccgg tcgttactag gcctggactc     3360

gggggagctg cagtccggcc cggagtcgag ctccagcccc ggggtgcatg tgagacagac     3420

caaggaggcg ccggccaagc tggagtccca ggctgggcag caggtgtccc gtggggcccg     3480

ggatcgggtc cgttccatgt cggggggcca tggtcttcga gttggcgccc tggacgtgcc     3540

ggcctcccag ttcctgggca gtgccacttc tccaggacca cggactgcac cagccgcgaa     3600

acctgagaag gcctcagctg gcacccgggt tcctgtgcag gagaagacga acctggcggc     3660

ctatgtgccc ctgctgaccc agggctgggc ggagatcctg gtccggaggc ccacagggaa     3720

caccagctgg ctgatgagcc tggagaaccc gctcagccct ttctcctcgg acatcaacaa     3780

catgcccctg caggagctgt ctaacgccct catggcggct gagcgcttca aggagcaccg     3840

ggacacagcc ctgtacaagt cactgtcggt gccggcagcc agcacggcca aaccccctcc     3900

tctgcctcgc tccaacacag actccgccgt ggtcatggag gagggaagtc cgggcgaggt     3960

tcctgtgctg gtggagcccc cagggttgga ggacgttgag gcagcgctag gcatggacag     4020

gcgcacggat gcctacagca ggtcgtcctc agtctccagc caggaggaga agtcgctcca     4080

cgcggaggag ctggttggca ggggcatccc catcgagcga gtcgtctcct cggagggtgg     4140

ccggccctct gtggacctct ccttccagcc ctcgcagccc ctgagcaagt ccagctcctc     4200

tcccgagctg cagactctgc aggacatcct cggggaccct ggggacaagg ccgacgtggg     4260

ccggctgagc cctgaggtta aggcccggtc acagtcaggg accctggacg gggaaagtgc     4320

tgcctggtcg gcctcgggcg aagacagtcg gggccagccc gagggtccct tgccttccag     4380

ctccccccgc tcgcccagtg gcctccggcc ccgaggttac accatctccg actcggcccc     4440

atcacgcagg ggcaagagag tagagaggga cgccttaaag agcagagcca cagcctccaa     4500

tgcagagaaa gtgccaggca tcaaccccag tttcgtgttc ctgcagctct accattcccc     4560

cttctttggc gacgagtcaa acaagccaat cctgctgccc aatgagtcac agtcctttga     4620

gcggtcggtg cagctcctcg accagatccc atcatacgac acccacaaga tcgccgtcct     4680

gtatgttgga gaaggccaga gcaacagcga gctcgccatc ctgtccaatg agcatggctc     4740

ctacaggtac acggagttcc tgacgggcct gggccggctc atcgagctga aggactgcca     4800

gccggacaag gtgtacctgg gaggcctgga cgtgtgtggt gaggacggcc agttcaccta     4860

ctgctggcac gatgacatca tgcaagccgt cttccacatc gccaccctga tgcccaccaa     4920

ggacgtggac aagcaccgct gcgacaagaa gcgccacctg ggcaacgact ttgtgtccat     4980

tgtctacaat gactccggtg aggacttcaa gcttggcacc atcaagggcc agttcaactt     5040

tgtccacgtg atcgtcaccc cgctggacta cgagtgcaac ctggtgtccc tgcagtgcag     5100

gaaagacatg gagggccttg tggacaccag cgtggccaag atcgtgtctg accgcaacct     5160

gcccttcgtg gcccgccaga tggccctgca cgcaaatatg gcctcacagg tgcatcatag     5220

ccgctccaac cccaccgata tctacccctc caagtggatt gcccggctcc gccacatcaa     5280

gcggctccgc cagcggatct gcgaggaagc cgcctactcc aaccccagcc tacctctggt     5340

gcaccctccg tcccatagca aagcccctgc acagactcca gccgagccca cacctggcta     5400

tgaggtgggc cagcggaagc gcctcatctc ctcggtggag gacttcaccg agtttgtgtg     5460

aggccggggc cctccctcct gcactggcct tggacggtat tgcctgtcag tgaaataaat     5520

aaagtcctga ccccagtgca cagacataga ggcacagatt gcaaaaaaaa aaaaaaa        5577


<210>  34
<211>  1784
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Ser Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser 
945                 950                 955                 960 


Pro Pro Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg 
                965                 970                 975     


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            980                 985                 990         


Thr Ser Leu Thr Ser Ala Ser Leu  Gly Ser Ala Asp Glu  Asn Ser Val 
        995                 1000                 1005             


Ala Gln  Ala Asp Asp Ser Leu  Lys Asn Leu His Leu  Glu Leu Thr 
    1010                 1015                 1020             


Glu Thr  Cys Leu Asp Met Met  Ala Arg Tyr Val Phe  Ser Asn Phe 
    1025                 1030                 1035             


Thr Ala  Val Pro Lys Arg Ser  Pro Val Gly Glu Phe  Leu Leu Ala 
    1040                 1045                 1050             


Gly Gly  Arg Thr Lys Thr Trp  Leu Val Gly Asn Lys  Leu Val Thr 
    1055                 1060                 1065             


Val Thr  Thr Ser Val Gly Thr  Gly Thr Arg Ser Leu  Leu Gly Leu 
    1070                 1075                 1080             


Asp Ser  Gly Glu Leu Gln Ser  Gly Pro Glu Ser Ser  Ser Ser Pro 
    1085                 1090                 1095             


Gly Val  His Val Arg Gln Thr  Lys Glu Ala Pro Ala  Lys Leu Glu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Gln Gln Val  Ser Arg Gly Ala Arg  Asp Arg Val 
    1115                 1120                 1125             


Arg Ser  Met Ser Gly Gly His  Gly Leu Arg Val Gly  Ala Leu Asp 
    1130                 1135                 1140             


Val Pro  Ala Ser Gln Phe Leu  Gly Ser Ala Thr Ser  Pro Gly Pro 
    1145                 1150                 1155             


Arg Thr  Ala Pro Ala Ala Lys  Pro Glu Lys Ala Ser  Ala Gly Thr 
    1160                 1165                 1170             


Arg Val  Pro Val Gln Glu Lys  Thr Asn Leu Ala Ala  Tyr Val Pro 
    1175                 1180                 1185             


Leu Leu  Thr Gln Gly Trp Ala  Glu Ile Leu Val Arg  Arg Pro Thr 
    1190                 1195                 1200             


Gly Asn  Thr Ser Trp Leu Met  Ser Leu Glu Asn Pro  Leu Ser Pro 
    1205                 1210                 1215             


Phe Ser  Ser Asp Ile Asn Asn  Met Pro Leu Gln Glu  Leu Ser Asn 
    1220                 1225                 1230             


Ala Leu  Met Ala Ala Glu Arg  Phe Lys Glu His Arg  Asp Thr Ala 
    1235                 1240                 1245             


Leu Tyr  Lys Ser Leu Ser Val  Pro Ala Ala Ser Thr  Ala Lys Pro 
    1250                 1255                 1260             


Pro Pro  Leu Pro Arg Ser Asn  Thr Asp Ser Ala Val  Val Met Glu 
    1265                 1270                 1275             


Glu Gly  Ser Pro Gly Glu Val  Pro Val Leu Val Glu  Pro Pro Gly 
    1280                 1285                 1290             


Leu Glu  Asp Val Glu Ala Ala  Leu Gly Met Asp Arg  Arg Thr Asp 
    1295                 1300                 1305             


Ala Tyr  Ser Arg Ser Ser Ser  Val Ser Ser Gln Glu  Glu Lys Ser 
    1310                 1315                 1320             


Leu His  Ala Glu Glu Leu Val  Gly Arg Gly Ile Pro  Ile Glu Arg 
    1325                 1330                 1335             


Val Val  Ser Ser Glu Gly Gly  Arg Pro Ser Val Asp  Leu Ser Phe 
    1340                 1345                 1350             


Gln Pro  Ser Gln Pro Leu Ser  Lys Ser Ser Ser Ser  Pro Glu Leu 
    1355                 1360                 1365             


Gln Thr  Leu Gln Asp Ile Leu  Gly Asp Pro Gly Asp  Lys Ala Asp 
    1370                 1375                 1380             


Val Gly  Arg Leu Ser Pro Glu  Val Lys Ala Arg Ser  Gln Ser Gly 
    1385                 1390                 1395             


Thr Leu  Asp Gly Glu Ser Ala  Ala Trp Ser Ala Ser  Gly Glu Asp 
    1400                 1405                 1410             


Ser Arg  Gly Gln Pro Glu Gly  Pro Leu Pro Ser Ser  Ser Pro Arg 
    1415                 1420                 1425             


Ser Pro  Ser Gly Leu Arg Pro  Arg Gly Tyr Thr Ile  Ser Asp Ser 
    1430                 1435                 1440             


Ala Pro  Ser Arg Arg Gly Lys  Arg Val Glu Arg Asp  Ala Leu Lys 
    1445                 1450                 1455             


Ser Arg  Ala Thr Ala Ser Asn  Ala Glu Lys Val Pro  Gly Ile Asn 
    1460                 1465                 1470             


Pro Ser  Phe Val Phe Leu Gln  Leu Tyr His Ser Pro  Phe Phe Gly 
    1475                 1480                 1485             


Asp Glu  Ser Asn Lys Pro Ile  Leu Leu Pro Asn Glu  Ser Gln Ser 
    1490                 1495                 1500             


Phe Glu  Arg Ser Val Gln Leu  Leu Asp Gln Ile Pro  Ser Tyr Asp 
    1505                 1510                 1515             


Thr His  Lys Ile Ala Val Leu  Tyr Val Gly Glu Gly  Gln Ser Asn 
    1520                 1525                 1530             


Ser Glu  Leu Ala Ile Leu Ser  Asn Glu His Gly Ser  Tyr Arg Tyr 
    1535                 1540                 1545             


Thr Glu  Phe Leu Thr Gly Leu  Gly Arg Leu Ile Glu  Leu Lys Asp 
    1550                 1555                 1560             


Cys Gln  Pro Asp Lys Val Tyr  Leu Gly Gly Leu Asp  Val Cys Gly 
    1565                 1570                 1575             


Glu Asp  Gly Gln Phe Thr Tyr  Cys Trp His Asp Asp  Ile Met Gln 
    1580                 1585                 1590             


Ala Val  Phe His Ile Ala Thr  Leu Met Pro Thr Lys  Asp Val Asp 
    1595                 1600                 1605             


Lys His  Arg Cys Asp Lys Lys  Arg His Leu Gly Asn  Asp Phe Val 
    1610                 1615                 1620             


Ser Ile  Val Tyr Asn Asp Ser  Gly Glu Asp Phe Lys  Leu Gly Thr 
    1625                 1630                 1635             


Ile Lys  Gly Gln Phe Asn Phe  Val His Val Ile Val  Thr Pro Leu 
    1640                 1645                 1650             


Asp Tyr  Glu Cys Asn Leu Val  Ser Leu Gln Cys Arg  Lys Asp Met 
    1655                 1660                 1665             


Glu Gly  Leu Val Asp Thr Ser  Val Ala Lys Ile Val  Ser Asp Arg 
    1670                 1675                 1680             


Asn Leu  Pro Phe Val Ala Arg  Gln Met Ala Leu His  Ala Asn Met 
    1685                 1690                 1695             


Ala Ser  Gln Val His His Ser  Arg Ser Asn Pro Thr  Asp Ile Tyr 
    1700                 1705                 1710             


Pro Ser  Lys Trp Ile Ala Arg  Leu Arg His Ile Lys  Arg Leu Arg 
    1715                 1720                 1725             


Gln Arg  Ile Cys Glu Glu Ala  Ala Tyr Ser Asn Pro  Ser Leu Pro 
    1730                 1735                 1740             


Leu Val  His Pro Pro Ser His  Ser Lys Ala Pro Ala  Gln Thr Pro 
    1745                 1750                 1755             


Ala Glu  Pro Thr Pro Gly Tyr  Glu Val Gly Gln Arg  Lys Arg Leu 
    1760                 1765                 1770             


Ile Ser  Ser Val Glu Asp Phe  Thr Glu Phe Val 
    1775                 1780                 


