                         SEQUENCE LISTING

<110>  YALE UNIVERSITY
 
<120>  INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE 
       THEREOF

<130>  117950-00720

<140>  PCT/US2011/021109
<141>  2011-01-13

<150>  US 61/335,950
<151>  2010-01-14

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR1 fragment

<400>  1

Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
1               5                   10                  15      


Leu Ala Glu 
            


<210>  2
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR2 fragment

<400>  2

Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
1               5                   10                  15      


Met Ala 
        


<210>  3
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR1 fragment

<400>  3

Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
1               5                   10                  15      


Pro Glu 
        


<210>  4
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR2 fragment

<400>  4

Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
1               5                   10                  15      


Pro Glu 
        


<210>  5
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR1 fragment

<400>  5

Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn 
1               5                   10                  15      


Pro Ser 
        


<210>  6
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR2 fragment

<400>  6

Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp 
1               5                   10                  15      


Ile Asn 
        


<210>  7
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR1 fragment

<400>  7

Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu 
1               5                   10                  15      


Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR2 fragment

<400>  8

Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu 
1               5                   10                  15      


Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr 
            20                  25                  30      


<210>  9
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR1 fragment

<400>  9

Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg 
1               5                   10                  15      


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
            20                  25                  30          


Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg 
        35                  40                  45              


Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys 
    50                  55                  60                  


Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly 
65                  70                  75                  80  


Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly 
                85                  90                  95      


Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu 
            100                 105                 110         


Tyr Leu Gln Ala Arg Arg Pro Pro 
        115                 120 


<210>  10
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR2 fragment

<400>  10

Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg 
1               5                   10                  15      


Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
            20                  25                  30          


Val Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu 
        35                  40                  45              


Ala Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys 
    50                  55                  60                  


Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly 
65                  70                  75                  80  


Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly 
                85                  90                  95      


Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Arg Pro Pro 
        115                 120 


<210>  11
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR3 fragment

<400>  11

Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg 
1               5                   10                  15      


Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
            20                  25                  30          


Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys 
        35                  40                  45              


Pro Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys 
    50                  55                  60                  


Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly 
65                  70                  75                  80  


Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly 
                85                  90                  95      


Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu 
            100                 105                 110         


Phe Leu Arg Ala Arg Arg Pro Pro 
        115                 120 


<210>  12
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR4 fragment

<400>  12

Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
1               5                   10                  15      


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
            20                  25                  30          


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
        35                  40                  45              


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
    50                  55                  60                  


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
65                  70                  75                  80  


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
                85                  90                  95      


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
            100                 105                 110         


Phe Leu Arg Ala Arg Arg Pro Pro 
        115                 120 


<210>  13
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR1 fragment

<400>  13

Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys 
1               5                   10                  15      


Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
            20                  25                  30          


Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
        35                  40                  45              


Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
    50                  55                  60                  


Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met 
65                  70                  75                  80  


Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp 
                85                  90                  95      


Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
            100                 105                 110         


Glu Asp Leu Asp Arg Ile Val Ala 
        115                 120 


<210>  14
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR2 fragment

<400>  14

Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys 
1               5                   10                  15      


Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
            20                  25                  30          


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
        35                  40                  45              


Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
    50                  55                  60                  


Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met 
65                  70                  75                  80  


Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp 
                85                  90                  95      


Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
            100                 105                 110         


Glu Asp Leu Asp Arg Ile Leu Thr 
        115                 120 


<210>  15
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR3 fragment

<400>  15

Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp Tyr Tyr Lys 
1               5                   10                  15      


Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
            20                  25                  30          


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
        35                  40                  45              


Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
    50                  55                  60                  


Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met 
65                  70                  75                  80  


Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile Met Arg Glu 
                85                  90                  95      


Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
            100                 105                 110         


Glu Asp Leu Asp Arg Val Leu Thr 
        115                 120 


<210>  16
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human FGFR4 fragment

<400>  16

Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys 
1               5                   10                  15      


Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
            20                  25                  30          


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
        35                  40                  45              


Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
    50                  55                  60                  


Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met 
65                  70                  75                  80  


Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly Leu Met Arg Glu 
                85                  90                  95      


Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
            100                 105                 110         


Glu Ala Leu Asp Lys Val Leu 
        115                 

 

