                         SEQUENCE LISTING

<110>  Amgen Inc.
 
<120>  IL-22-Fc and Hepcidin Activity

<130>  A-1525-WO-PCT

<140>  Not Yet Assigned
<141>  2011-01-10

<150>  US 61/294,595
<151>  2010-01-13

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  396
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  VH5 leader sequence

<220>
<221>  MISC_FEATURE
<222>  (241)..(245)
<223>  Linker sequence

<400>  1

Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
            20                  25                  30          


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
        35                  40                  45              


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
    50                  55                  60                  


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
65                  70                  75                  80  


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
                85                  90                  95      


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
            100                 105                 110         


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
        115                 120                 125             


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
    130                 135                 140                 


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
145                 150                 155                 160 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
                165                 170                 175     


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
            180                 185                 190         


Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
        195                 200                 205             


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
    210                 215                 220                 


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gln Glu Ala Asn Ala Leu Pro Val Asn Thr Arg 
                245                 250                 255     


Cys Lys Leu Glu Val Ser Asn Phe Gln Gln Pro Tyr Ile Val Asn Arg 
            260                 265                 270         


Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp 
        275                 280                 285             


Val Arg Leu Ile Gly Glu Lys Leu Phe Arg Gly Val Ser Ala Lys Asp 
    290                 295                 300                 


Gln Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Asp Val 
305                 310                 315                 320 


Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val 
                325                 330                 335     


Pro Phe Leu Thr Lys Leu Ser Asn Gln Leu Ser Ser Cys His Ile Ser 
            340                 345                 350         


Gly Asp Asp Gln Asn Ile Gln Lys Asn Val Arg Arg Leu Lys Glu Thr 
        355                 360                 365             


Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu 
    370                 375                 380                 


Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Val 
385                 390                 395     


<210>  2
<211>  377
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (222)..(226)
<223>  Linker sequence

<400>  2

Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            20                  25                  30          


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        35                  40                  45              


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    50                  55                  60                  


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
65                  70                  75                  80  


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                85                  90                  95      


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            100                 105                 110         


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        115                 120                 125             


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    130                 135                 140                 


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
145                 150                 155                 160 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
                165                 170                 175     


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            180                 185                 190         


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        195                 200                 205             


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gln Glu Ala Asn Ala Leu Pro Val Asn Thr Arg Cys Lys Leu 
225                 230                 235                 240 


Glu Val Ser Asn Phe Gln Gln Pro Tyr Ile Val Asn Arg Thr Phe Met 
                245                 250                 255     


Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu 
            260                 265                 270         


Ile Gly Glu Lys Leu Phe Arg Gly Val Ser Ala Lys Asp Gln Cys Tyr 
        275                 280                 285             


Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Asp Val Leu Leu Pro 
    290                 295                 300                 


Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu 
305                 310                 315                 320 


Thr Lys Leu Ser Asn Gln Leu Ser Ser Cys His Ile Ser Gly Asp Asp 
                325                 330                 335     


Gln Asn Ile Gln Lys Asn Val Arg Arg Leu Lys Glu Thr Val Lys Lys 
            340                 345                 350         


Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu 
        355                 360                 365             


Phe Met Ser Leu Arg Asn Ala Cys Val 
    370                 375         


<210>  3
<211>  1188
<212>  DNA
<213>  Mus musculus

<400>  3
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgcctgt       60

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      120

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      180

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      240

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      300

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa cagtgcagct      360

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag      420

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc      480

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca      540

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac      600

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg      660

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa      720

ggaggcggtg gaagccagga ggcaaatgcg ctgcccgtca acacccggtg caagcttgag      780

gtgtccaact tccagcagcc gtacatcgtc aaccgcacct ttatgctggc caaggaggcc      840

agccttgcag ataacaacac agacgtccgg ctcatcgggg agaaactgtt ccgaggagtc      900

agtgctaaag atcagtgcta cctgatgaag caggtgctca acttcaccct ggaagacgtt      960

ctgctccccc agtcagacag gttccagccc tacatgcagg aggtggtacc tttcctgacc     1020

aaactcagca atcagctcag ctcctgtcac atcagcggtg acgaccagaa catccagaag     1080

aatgtcagaa ggctgaagga gacagtgaaa aagcttggag agagtggaga gatcaaggcg     1140

attggggaac tggacctgct gtttatgtct ctgagaaatg cttgcgtc                  1188


<210>  4
<211>  383
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (152)..(156)
<223>  Linker sequence

<400>  4

Gln Gly Gly Ala Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys 
1               5                   10                  15      


Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala 
            20                  25                  30          


Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly 
        35                  40                  45              


Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met 
    50                  55                  60                  


Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser 
65                  70                  75                  80  


Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg 
                85                  90                  95      


Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His 
            100                 105                 110         


Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly 
        115                 120                 125             


Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met 
    130                 135                 140                 


Ser Leu Arg Asn Ala Cys Ile Gly Gly Gly Gly Ser Asp Lys Thr His 
145                 150                 155                 160 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                165                 170                 175     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            180                 185                 190         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        195                 200                 205             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    210                 215                 220                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
225                 230                 235                 240 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                245                 250                 255     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            260                 265                 270         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        275                 280                 285             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    290                 295                 300                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
305                 310                 315                 320 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                325                 330                 335     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            340                 345                 350         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        355                 360                 365             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380             


<210>  5
<211>  383
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (228)..(232)
<223>  Linker sequence

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gln Gly Gly Ala Ala Ala Pro Ile 
225                 230                 235                 240 


Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile 
                245                 250                 255     


Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn 
            260                 265                 270         


Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser 
        275                 280                 285             


Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu 
    290                 295                 300                 


Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln 
305                 310                 315                 320 


Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys 
                325                 330                 335     


His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu 
            340                 345                 350         


Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile 
        355                 360                 365             


Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
    370                 375                 380             


