                         SEQUENCE LISTING

<110>  INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD)
 
<120>  Mthode pour valuer l'efficacit de stratgies de lutte 
       anti-vectorielle dans le contrle du paludisme et des arboviroses

<130>  CP 63037-3309

<160>  30    

<170>  PatentIn version 3.3

<210>  1
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  gSG6 Protein


<220>
<221>  SIGNAL
<222>  (1)..(28)
<223>  peptide

<400>  1

Met Ala Ile Arg Val Glu Leu Leu Leu Ala Met Val Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Leu Glu Ser Val Val Pro His Ala Ala Ala Glu Lys Val Trp 
            20                  25                  30          


Val Asp Arg Asp Asn Val Tyr Cys Gly His Leu Asp Cys Thr Arg Val 
        35                  40                  45              


Ala Thr Phe Lys Gly Glu Arg Phe Cys Thr Leu Cys Asp Thr Arg His 
    50                  55                  60                  


Phe Cys Glu Cys Lys Glu Thr Arg Glu Pro Leu Pro Tyr Met Tyr Ala 
65                  70                  75                  80  


Cys Pro Gly Thr Glu Pro Cys Gln Ser Ser Asp Arg Leu Gly Ser Cys 
                85                  90                  95      


Ser Lys Ser Met His Asp Val Leu Cys Asp Arg Ile Asp Gln Ala Phe 
            100                 105                 110         


Leu Glu Gln 
        115 


<210>  2
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide P1 of gSG6 protein

<400>  2

Glu Lys Val Trp Val Asp Arg Asp Asn Val Tyr Cys Gly His Leu Asp 
1               5                   10                  15      


Cys Thr Arg Val Ala Thr Phe 
            20              


<210>  3
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide P2 of gSG6 protein

<400>  3

Ala Thr Phe Lys Gly Glu Arg Phe Cys Thr Leu Cys Asp Thr Arg His 
1               5                   10                  15      


Phe Cys Glu Cys Lys Glu Thr Arg Glu Pro Leu 
            20                  25          


<210>  4
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide P3 of gSG6 protein

<400>  4

Cys Glu Cys Lys Glu Thr Arg Glu Pro Leu Pro Tyr Met Tyr Ala Cys 
1               5                   10                  15      


Pro Gly Thr Glu Pro 
            20      


<210>  5
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide P4 of gSG6 protein

<400>  5

Ala Cys Pro Gly Thr Glu Pro Cys Gln Ser Ser Asp Arg Leu Gly Ser 
1               5                   10                  15      


Cys Ser Lys Ser 
            20  


<210>  6
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide P5 of gSG6 protein

<400>  6

Asp Arg Leu Gly Ser Cys Ser Lys Ser Met His Asp Val Leu Cys Asp 
1               5                   10                  15      


Arg Ile Asp Gln Ala Phe Leu Glu Gln 
            20                  25  


<210>  7
<211>  260
<212>  PRT
<213>  Artificial sequence

<220>
<223>  gVAG protein

<400>  7

Met Ala Ile Trp Ile Ala Cys Ala Thr Leu Leu Leu Val Val Leu Ser 
1               5                   10                  15      


Gly Val Ser Ala Gly Gly Lys Tyr Cys Ser Ser Asp Leu Cys Pro Arg 
            20                  25                  30          


Gly Gly Pro His Val Gly Cys Asn Pro Pro Ser Ser Ser Gly Gly Pro 
        35                  40                  45              


Thr Cys Gln Gly Lys Gln Lys Ala Arg Lys Val Leu Leu Thr Pro Ala 
    50                  55                  60                  


Leu Gln Ala Tyr Ile Met Asp Glu His Asn Leu Asn Arg Ser Asn Ile 
65                  70                  75                  80  


Ala Leu Gly Arg Ile Arg Pro Tyr Pro Ser Ala Val Lys Met Pro Thr 
                85                  90                  95      


Leu Thr Trp Asp Pro Glu Leu Ala Ser Leu Ala Asp Ala Asn Ala Arg 
            100                 105                 110         


Ser Cys Asn Tyr Gly His Asp Arg Cys Arg Ala Thr Lys Lys Phe Pro 
        115                 120                 125             


Tyr Ala Gly Gln Asn Ile Ala Ile Thr Gln Phe Phe Gly Tyr Arg Phe 
    130                 135                 140                 


Thr Glu Lys Asp Leu Ile His Lys Phe Val Ser Ser Trp Trp Ser Glu 
145                 150                 155                 160 


Tyr Leu Asp Ala Arg Pro Glu His Val Arg Lys Tyr Pro Ser Ser Tyr 
                165                 170                 175     


Ser Gly Lys Pro Ile Gly His Phe Thr Gln Ile Ala Ser Asp Arg Ser 
            180                 185                 190         


Thr Lys Val Gly Cys Ser Met Trp Tyr Trp Lys Asp Gly Gln Met Asp 
        195                 200                 205             


Val Tyr Tyr Phe Val Cys Asn Tyr Ser Phe Thr Asn Ile Met Asp Arg 
    210                 215                 220                 


Ser Val Tyr Gln Ser Gly Pro Thr Ala Ser Gln Cys Lys Thr Gly Arg 
225                 230                 235                 240 


Asn Ser Lys Phe Pro Gly Leu Cys Asn Ala Ser Glu Glu Pro Arg Ser 
                245                 250                 255     


Ile Met Asp Pro 
            260 


<210>  8
<211>  570
<212>  PRT
<213>  Artificial sequence

<220>
<223>  5' nucleotidase

<400>  8

Met Ala Leu Val Arg Phe Ala Thr Ile Ile Thr Val Leu Cys His Leu 
1               5                   10                  15      


Ala Ile Gln Asp Gly Ala Ala Lys Ser Phe Pro His Gly Glu Lys Ala 
            20                  25                  30          


Pro Phe Pro Leu Thr Leu Ile His Ile Asn Asp Leu His Ala Arg Phe 
        35                  40                  45              


Asp Glu Thr Asn Gln Lys Ser Ser Thr Cys Thr Asn Ser Lys Glu Cys 
    50                  55                  60                  


Ile Ala Gly Ile Ala Arg Val Tyr His Thr Ile Lys Gln Leu Lys Ser 
65                  70                  75                  80  


Glu Tyr Lys Thr Lys Asn Pro Leu Tyr Leu Asn Ala Gly Asp Asn Phe 
                85                  90                  95      


Gln Gly Thr Leu Trp Tyr Asn Leu Leu Arg Trp Asn Val Thr Ala Tyr 
            100                 105                 110         


Phe Ile Lys Glu Leu Pro Pro Asp Ala Met Thr Leu Gly Asn His Glu 
        115                 120                 125             


Phe Asp His Ser Pro Lys Gly Leu Ala Pro Tyr Leu Ala Glu Leu Glu 
    130                 135                 140                 


Lys Met Lys Ile Pro Thr Val Val Ala Asn Leu Glu Lys Asn Gly Glu 
145                 150                 155                 160 


Pro Ala Leu Lys Asp Ser Lys Ile Ala Pro Gln Ile Val Leu Lys Val 
                165                 170                 175     


Gly Asn Arg Lys Val Gly Val Ile Gly Ala Leu Tyr Asp Lys Thr His 
            180                 185                 190         


Leu Val Ala Gln Thr Gly Met Val Thr Leu Thr Asn Ser Ile Glu Ala 
        195                 200                 205             


Val Arg Lys Glu Ala Gln Glu Leu Lys Lys Lys Asn Val Asn Ile Ile 
    210                 215                 220                 


Val Val Leu Ser His Cys Gly Leu Asp Gly Asp Lys Gln Leu Ala Glu 
225                 230                 235                 240 


Glu Ala Gly Asp Leu Ile Asp Val Ile Val Gly Ala His Ser His Ser 
                245                 250                 255     


Leu Leu Leu Asn Lys Asp Ala Lys Val Pro Tyr Asp Thr Lys Tyr Asp 
            260                 265                 270         


Thr Ile Glu Gly Asp Tyr Pro Leu Val Val Lys Lys Ser Asn Asn His 
        275                 280                 285             


Thr Val Leu Ile Thr Gln Ala Arg Ser Phe Gly Lys Tyr Val Gly Arg 
    290                 295                 300                 


Leu Thr Val Asn Phe Asp Cys Glu Gly Glu Val Gln Ser Trp Glu Gly 
305                 310                 315                 320 


Tyr Pro Ile Tyr Met Asn Asn Ser Val Lys Gln Asp Glu Glu Val Leu 
                325                 330                 335     


Arg Glu Leu Glu Pro Trp Arg Ala Glu Val Lys Arg Leu Gly Thr Gln 
            340                 345                 350         


Val Ile Gly Thr Thr Glu Val Phe Leu Asp Arg Glu Ser Cys Arg Trp 
        355                 360                 365             


Cys Glu Cys Thr Leu Gly Asp Leu Ile Ala Asp Ala Tyr Ala Asp Gln 
    370                 375                 380                 


Tyr Thr Asn Ser Thr Val Gln Pro Val Ala Phe Val Gln Ala Gly Asn 
385                 390                 395                 400 


Phe Arg Asn Pro Ile Glu Lys Gly Asp Ile Thr Asn Gly Leu Ala Ile 
                405                 410                 415     


Glu Ala Ala Pro Tyr Gly Ser Ser Val Asp Met Ile Lys Leu Ser Gly 
            420                 425                 430         


Ala Asp Leu Trp Ser Ala Ile Asp His Ser Phe Thr Leu Asp Asp Glu 
        435                 440                 445             


Phe Arg Tyr Asn Thr Ala Gln Val Ser Gly Met Thr Val Val Ala Asp 
    450                 455                 460                 


Leu Ser Lys Lys Pro Tyr Glu Arg Val Gln Ser Ile Asp Ile Val Gly 
465                 470                 475                 480 


Ala Asn Gly Ala Lys Thr Ala Leu Lys Lys Asp Gln Ile Tyr Tyr Val 
                485                 490                 495     


Ala Val Pro Ser Tyr Leu Ala Asp Gly Lys Asp Gly Phe Ala Met Leu 
            500                 505                 510         


Lys Lys Gly Thr Asn Arg Val Thr Gly Pro Leu Asp Ser Asp Val Leu 
        515                 520                 525             


Ile Glu Tyr Val Arg Lys Arg Gln Thr Ile Ala Lys Thr Met Phe Gln 
    530                 535                 540                 


Glu Lys Arg Val Val Ile Glu Asn His Thr Asn Gly Thr Cys Ser Trp 
545                 550                 555                 560 


Asp Leu Asp Ser Gln Arg Tyr Lys Pro Lys 
                565                 570 


<210>  9
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SG1-like

<400>  9

Met Ala Gly Gln Arg His Leu Ile Glu Gln Ala Trp Gln Tyr Gly Ala 
1               5                   10                  15      


Gln Leu Gln His Glu Leu Met Leu Thr Ser Met Glu Ser Asp Arg Val 
            20                  25                  30          


Gln Arg Ala Leu Val Leu His Ser Met Leu Val Asn Ala Ser Leu Ala 
        35                  40                  45              


Glu Met Val Lys Glu Ser Tyr Gln Thr His Gly Ala Asp Gly Arg Met 
    50                  55                  60                  


Val Val Arg Met Leu Lys Phe Val Arg Leu Leu Pro Gly Ala Asp Glu 
65                  70                  75                  80  


Arg Val Ala Val Tyr Lys Gln Leu Ala Glu Leu Leu Lys Ser Asn Gly 
                85                  90                  95      


Gln Asp Gly Arg Phe Pro Ala Val Ile Phe Ser Thr Asp Val Arg Gln 
            100                 105                 110         


Leu Glu Asp Arg Tyr Lys Pro Asp His Ala Gln Tyr Glu Gly Lys Val 
        115                 120                 125             


Val Glu Arg Trp Leu Ala Glu Leu Gln Ala Gly Thr Phe His Glu Val 
    130                 135                 140                 


Val Glu Phe Ala Arg Asp Tyr Pro Glu Tyr Phe Ala Arg Val Glu Glu 
145                 150                 155                 160 


Pro Leu Tyr Glu Thr Leu Lys Gln Gln Trp Ser Ala Glu Gly Leu Asp 
                165                 170                 175     


Arg Met Val Ser Phe Pro Asn Ala Leu Pro Val Gly Val Gln Arg Val 
            180                 185                 190         


Arg Ala Leu Arg Ala Leu Leu Glu Thr Leu Leu Gln His Gln Gly Glu 
        195                 200                 205             


Gln Asn Asn Asp Val Tyr Leu Ile Arg Leu Ala His Glu Thr Gly Arg 
    210                 215                 220                 


Val Glu Ala Thr Val Gly Gln Ala Asp Ala Ala Val Arg Gln Ala Leu 
225                 230                 235                 240 


Asp Asp Val Lys Lys Leu Phe Glu Gln Phe Lys Tyr Gln Arg Gly Phe 
                245                 250                 255     


Pro Asp Tyr Glu Ala Leu Tyr Lys Leu Phe Lys Gly Leu 
            260                 265                 


<210>  10
<211>  312
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  peptide

<400>  10

Met Ser Pro Ser Asn Lys Ile Leu Val Leu Leu Leu Phe Pro Ile Leu 
1               5                   10                  15      


Leu Val Ser Ser His Pro Ile Pro Ala Glu Asp Pro Ala Lys Gln Cys 
            20                  25                  30          


Asn Leu Ser Glu Asp Asp Leu Thr Lys Leu Lys Ala Ala Ile Ser Gly 
        35                  40                  45              


Ala Ser Ser Ala Lys Ala Ala Asn Glu Asp Ile Leu Pro Asn Thr Thr 
    50                  55                  60                  


Leu Ala Ala Cys Pro Met Leu Lys Asn Phe Thr Glu Met Leu Lys Thr 
65                  70                  75                  80  


Val Ala Thr Asp Met Glu Val Leu Lys Thr Gln Gly Val Ser Asn Met 
                85                  90                  95      


Glu Val Gln Leu Leu Arg Glu Ser Phe Glu Glu Lys Leu Asn Asp Leu 
            100                 105                 110         


Ala Lys Asn Lys Asp Ile Phe Glu Arg Gln Ala Asn Gln Asp Thr Ser 
        115                 120                 125             


Lys Ala Glu Gly Glu Met Val Glu Lys Ile Asn Lys Leu Gln Leu Glu 
    130                 135                 140                 


Met Ala Lys Leu Gln Glu Glu Ile Glu Glu Gln Thr Lys Gln Met Tyr 
145                 150                 155                 160 


Val Asp Met Ile Glu Tyr Ile Phe Glu Arg Leu Lys Met Asn Asp Thr 
                165                 170                 175     


Glu Ala Ile Asp Ser Tyr Ala Gln Ile Val Met Lys Thr Lys Met His 
            180                 185                 190         


Glu Leu Ile Met Lys Leu Lys Thr Asp Arg Leu Val Leu Trp Glu Met 
        195                 200                 205             


Val Lys Tyr Val Glu Gly Lys Lys Asn Lys Trp Val Gly Arg Lys Val 
    210                 215                 220                 


Leu Asn Thr Ile Leu Asp Gln Val Asn Lys Leu Lys Leu Tyr Lys Pro 
225                 230                 235                 240 


Glu Glu Val Glu Ile Gly Lys Asn Ser Leu Val Val Val Trp Cys Trp 
                245                 250                 255     


Lys Phe Asn Ser Glu Thr Val Tyr Gly Thr Thr Asp Glu Asp Gln Lys 
            260                 265                 270         


Ser Phe His Leu Ala Lys Leu Phe Phe Pro Lys Glu Lys Gly Cys Lys 
        275                 280                 285             


Glu Cys Ala Asn Val Lys Ser Arg Thr Met Cys Asn Asn Asp Tyr Pro 
    290                 295                 300                 


Lys Val Met Val Lys Ala Phe Gly 
305                 310         


<210>  11
<211>  315
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  peptide

<400>  11

Met Glu Thr Ser Leu Pro Ile Thr Val Val Phe Pro Ile Val Leu Ile 
1               5                   10                  15      


Thr Gly Ala Gln Thr Lys Pro Thr Gln Gly Ser Cys Thr Leu Thr Asp 
            20                  25                  30          


Glu Asp Ile Ser Asp Ile Lys Ser Ala Val Gln Lys Ala Ser Lys Ala 
        35                  40                  45              


Ala Val Asn Asp Ile Val Leu Asp Pro Thr Leu Ile Asp Lys Cys Pro 
    50                  55                  60                  


Met Leu Glu Lys Ile Thr Ala Ser Leu Lys Ser Val Ala Thr Glu Ile 
65                  70                  75                  80  


Val Gln Met Arg Asp Ser Ala Ile Ser Thr Asp Gln Val Asp Gln Leu 
                85                  90                  95      


Lys Gln Asn Phe Glu Asp Gln Val Asn Gln Ile Val Lys Ser Arg Asp 
            100                 105                 110         


Ile Phe Glu Lys Gln Ser Gly Thr Gln Ala Thr Lys Glu His Gly Glu 
        115                 120                 125             


Met Leu Glu Arg Met Thr Ala Gln Val Lys Val Thr Glu Leu Glu Gln 
    130                 135                 140                 


Gln Ile Ala Lys Gln Thr Ala Ser Met Tyr Glu Asp Met Ala Glu Leu 
145                 150                 155                 160 


Ile Phe Gln Arg Leu Gln Met Asn Ser Thr Glu Ser Val Arg Ser Tyr 
                165                 170                 175     


Thr Lys His Met Met Glu Glu Lys Leu Glu Glu Leu Met Asn Lys Leu 
            180                 185                 190         


Glu Thr Asn Tyr Arg Ile Tyr Leu Gly Ala Leu Arg Phe Leu Asn His 
        195                 200                 205             


Met Asn Asp Gln Glu Leu Ile Gly Lys Val Phe Asp Gly Ile Leu Lys 
    210                 215                 220                 


Arg Leu Gly Asp Met Lys Ala Asp Ser Asp Asp Val Lys Glu Asn Gly 
225                 230                 235                 240 


Arg Asn Leu Leu Val Asn Leu Leu Cys Trp Thr Val Asn Asn Asp Phe 
                245                 250                 255     


Leu Gly Lys Lys Tyr Lys Glu Arg Gln Val Asp Leu Tyr Arg Met Ala 
            260                 265                 270         


Leu Lys Phe Tyr Pro Lys Thr Tyr Glu Lys Ala Ala Asn Glu Ala Asp 
        275                 280                 285             


Val Arg Ser Arg Gln Phe Cys Glu Glu Asn Phe Pro Ala Asn Leu Ile 
    290                 295                 300                 


Thr Trp Phe Ala Val Ser Trp Asn Asp Arg Gly 
305                 310                 315 


<210>  12
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  peptide

<400>  12

Met Lys Thr Ser Leu Pro Ile Val Val Leu Leu Thr Ala Val Ile Ser 
1               5                   10                  15      


Gly Val His Pro Asn Pro Thr Pro Lys Ser Cys Thr Val Ser Glu Glu 
            20                  25                  30          


Asp Leu Thr Thr Ile Arg Asn Ala Ile Gln Lys Ala Ser Arg Ala Ser 
        35                  40                  45              


Leu Asp Asp Val Asn Leu Asp Glu Asp Leu Ile Ala Lys Cys Pro Leu 
    50                  55                  60                  


Leu Lys Thr Ile Thr Ala Ser Leu Lys Ser Val Ala Ser Glu Ile Ala 
65                  70                  75                  80  


Thr Leu Lys Asp Thr Gly Ile Ser Glu Glu Gln Val Asp Glu Leu Lys 
                85                  90                  95      


Gln Ser Tyr Glu Gln Gln Val Asn Glu Ile Val Lys Ser Arg Asp Ile 
            100                 105                 110         


Phe Glu Lys Gln Ser Gly Gly Asp Val Met Lys Glu Gln Gly Ala Met 
        115                 120                 125             


Ile Asn Arg Met Thr Glu Leu Gln Val Gln Val Ala Gln Leu Gln Gln 
    130                 135                 140                 


Gln Ile Gly Glu Gln Thr Ser Arg Met Tyr Asp Asp Met Ala Glu Leu 
145                 150                 155                 160 


Ile Phe Gln Arg Leu Ala Met Asn Ser Thr Asp Ser Ile Arg Asn Tyr 
                165                 170                 175     


Thr Ala His Met Met Glu Gln Lys Leu His Thr Leu Met Thr Lys Leu 
            180                 185                 190         


Glu Thr Asn Tyr Arg Ile Phe Leu Gly Ala Leu Arg Tyr Leu Asp His 
        195                 200                 205             


Leu Gly Asp Gln Pro Leu Ile Asp Lys Val Phe Asp Gly Ile Leu Lys 
    210                 215                 220                 


Arg Leu Asp Glu Met Ser Leu Glu Thr Asn Lys Glu Arg Glu Asn Gly 
225                 230                 235                 240 


Lys Tyr Val Leu Val Asn Leu Leu Cys Trp Thr Val Asn Asn Arg Phe 
                245                 250                 255     


Leu Thr Glu Lys Tyr Arg Lys Lys Gln Leu Glu Leu Phe Arg Ile Ala 
            260                 265                 270         


Leu Lys Phe Tyr Pro Lys Thr Gly Asn Lys Glu Ala Asn Glu Ala Asp 
        275                 280                 285             


Ile Arg Gly Arg Gln Phe Cys Asp Ala Asn Phe Pro Val Asn Val Ile 
    290                 295                 300                 


Thr Trp Phe Ala Val Ser Arg Ala Ala Glu Gly Trp Gly Leu Arg Gly 
305                 310                 315                 320 


Thr Leu 
        


<210>  13
<211>  280
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  peptide

<400>  13

Met Pro Val Thr Tyr Glu Phe Phe Ile Leu Leu Ala Met Ser Leu Leu 
1               5                   10                  15      


Leu Val Arg Ser His Pro Leu Pro Glu Glu Ala Thr Ser Asp Ala Ala 
            20                  25                  30          


Ile Lys Cys Thr Leu Ser Glu Glu Asp Leu Asp Ser Leu Lys Arg Ala 
        35                  40                  45              


Ile Ser Ser Ala Ala Ser Ala Lys Ser Ser Asp Gly Ile Ile Leu Ser 
    50                  55                  60                  


Asn Glu Thr Leu Thr Ala Cys Pro Ile Leu Ala Asn Phe Thr Glu Met 
65                  70                  75                  80  


Leu Lys Thr Val Ala Thr Asp Met Glu Val Leu Lys Thr Gln Gly Val 
                85                  90                  95      


Ser Asn Ala Glu Val Glu Leu Leu Arg Glu Ser Phe Glu Glu Arg Leu 
            100                 105                 110         


Asn Glu Ile Thr Lys Asn Lys Asp Ile Phe Glu Arg Gln Ala Gly Gln 
        115                 120                 125             


Glu Thr Ser Lys Thr Glu Gly Gln Met Val Glu Lys Ile Asn Arg Leu 
    130                 135                 140                 


Gln Leu Glu Met Ala Ser Leu Lys Glu Glu Ile Glu Gln Glu Thr Lys 
145                 150                 155                 160 


Lys Met Tyr Glu Asp Met Ala Glu Tyr Ile Phe Gln Arg Leu Lys Met 
                165                 170                 175     


Asn Asp Thr Asp Ala Ile Asp Ser Tyr Ala Gln Ile Met Phe Lys Thr 
            180                 185                 190         


Lys Met His Asp Leu Phe Met Lys Leu Lys Thr Asp Arg Trp Val Leu 
        195                 200                 205             


Trp Lys Met Leu Asn Tyr Val Glu Gln Lys Lys Asp Lys Val Ile Gly 
    210                 215                 220                 


Lys Trp Val Leu Asn Thr Val Ile Asn Gln Val Thr Ser Leu Asn Arg 
225                 230                 235                 240 


Asn Lys Pro Asp Glu Leu Glu Ile Gly Lys Asp Ser Leu Val Asn Leu 
                245                 250                 255     


Leu Cys Trp Thr Ser Thr Ala Lys Thr Val Tyr Gly Ala Val Gln Glu 
            260                 265                 270         


Asp Gln Lys Met Phe Tyr Leu Thr 
        275                 280 


<210>  14
<211>  571
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide N-Term

<400>  14

Met Asn Pro Phe Thr Gln Val Phe Cys Leu Ile Val Gly Val Leu Phe 
1               5                   10                  15      


Phe Ala Phe Thr Ala Thr Ala Asp Glu Asp Cys Glu Ile Pro Leu Ser 
            20                  25                  30          


Glu Leu Asn Lys Ile Glu Gln Thr Leu Thr His Ile Glu Lys Pro Ile 
        35                  40                  45              


Tyr Thr Glu Glu Ala Glu Ser Glu Thr Ser Asp Ser Asp Glu Cys Ala 
    50                  55                  60                  


Gln Met Leu Arg Gly Ile His Leu Gln Leu Arg Arg Leu Thr Gln Lys 
65                  70                  75                  80  


Tyr Lys Leu Met Asn Lys Gly Tyr Val Lys Val Glu Glu Phe His Lys 
                85                  90                  95      


Met Ala Lys Glu Tyr Glu Glu Gln Leu Ser Lys Leu Asn Gly Glu Leu 
            100                 105                 110         


Glu Tyr Phe Lys Val Glu Ala Arg Ser Gly Ala Asp Gln Lys Ile Lys 
        115                 120                 125             


Glu Leu Lys Lys Asp Ile Lys Ser Leu Glu Gln Asn Val Thr Lys Leu 
    130                 135                 140                 


His Asp Arg Leu Lys Gly Ile Thr Asp Glu Leu Gly Lys Val Ser Met 
145                 150                 155                 160 


Glu Leu Cys Ser Thr Tyr Leu Glu Ser Asn Gln Leu Asp Ser Ala Lys 
                165                 170                 175     


Glu Lys Val Lys Asp Leu Pro Ser Lys Tyr Val Ile Glu Leu Val Asp 
            180                 185                 190         


Gln Phe Leu Ser Lys Asn Glu Asn Asn Trp Leu Pro Val Val Asp Leu 
        195                 200                 205             


Ser Thr Ala Val Pro Asp Leu Asp Asp Arg Gly Gln Val Tyr Lys Asn 
    210                 215                 220                 


Ile Tyr Glu Phe Leu Leu Ala Lys Ser Arg Leu Glu Gly Glu Glu Ser 
225                 230                 235                 240 


Leu Leu Leu Glu Ala Glu Ile Leu Lys Leu Asn Ala Thr Phe His Pro 
                245                 250                 255     


Gly Ser Lys Ile Thr Asp Asp Arg Lys Lys Glu Leu Asn Asp Leu Leu 
            260                 265                 270         


Glu Lys Leu Arg Gln Asn Ser Glu Lys Thr Phe Glu Gln Trp Ser Gln 
        275                 280                 285             


Glu Leu Asp Gln Ser Asn Ile Ser Ala Val Val Phe Lys Asn Ala Ile 
    290                 295                 300                 


Asp Arg Met Phe Leu Thr Gln Ile Glu Lys Phe Gly Glu Tyr Val Thr 
305                 310                 315                 320 


Gly Arg His Asp Tyr Tyr Gly Val Arg Asn Phe Leu Lys Leu Leu Gly 
                325                 330                 335     


Val Ser Lys Asn Tyr His Lys Ile Ala Ala Tyr Asn Ser Leu Val Glu 
            340                 345                 350         


Lys Lys Ile Gly His Ala Leu Ala Val Val Met Ile Asp Met Leu Ser 
        355                 360                 365             


Ile Asp Ile Ala Glu Ile Lys His Asp Pro His Val Pro Asp Arg Ile 
    370                 375                 380                 


Glu Arg Met Tyr Asn Ser Thr Ile Asn Ser Leu Pro Asp Ser Leu Lys 
385                 390                 395                 400 


Gly Ile Ile Pro Cys Ile Lys Ser Val Lys Ile Arg Asn Glu Gly Thr 
                405                 410                 415     


Asn Arg Cys Ile Tyr Ala Ile Asn Gln Asn Ile Gln Val Gln Asn Pro 
            420                 425                 430         


Asn Phe Lys Asn Ile Val Leu Gly Gln Tyr Lys Arg Val Thr Ser Thr 
        435                 440                 445             


Met Ser Ala Cys Thr Ser Phe Arg Leu Glu Leu Ser Ser Asn Lys Pro 
    450                 455                 460                 


Tyr Ile Lys Ile Ile Thr Ser Glu Gly Asn Ser Leu Thr Asn Ile Asn 
465                 470                 475                 480 


Ser Ala Val Pro Gly Glu Thr Gly Phe Ser Arg Val Gly Ala Pro Tyr 
                485                 490                 495     


Ser Asn Lys Pro Asn Met Lys Leu Asp His Thr Gly Asp Trp Val Leu 
            500                 505                 510         


Asp Ala Asn Phe Val Asn Asn Ser Ile Lys Ile Gln Ser Asp Phe Asn 
        515                 520                 525             


Ala Tyr Gln Thr Ser Lys Ser Ile Asp His Leu Val Val Arg Asn Asp 
    530                 535                 540                 


Gly Asp Val Ala Val Val Arg Tyr Gly Leu Ser Gly Met Arg Ser Gly 
545                 550                 555                 560 


Gly Ile Pro Asp Asn His Ala Glu Trp Lys Phe 
                565                 570     


<210>  15
<211>  571
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  15

Met Asn Pro Phe Thr Gln Val Phe Cys Leu Ile Val Gly Val Leu Phe 
1               5                   10                  15      


Phe Ala Phe Thr Ala Thr Ala Asp Glu Asp Cys Glu Ile Pro Leu Ser 
            20                  25                  30          


Glu Leu Asn Lys Ile Glu Gln Thr Leu Thr His Ile Glu Lys Pro Ile 
        35                  40                  45              


Tyr Thr Glu Glu Ala Glu Ser Glu Thr Ser Asp Ser Asp Glu Cys Ala 
    50                  55                  60                  


Gln Met Leu Arg Gly Ile His Leu Gln Leu Arg Arg Leu Thr Gln Lys 
65                  70                  75                  80  


Tyr Lys Leu Met Asn Lys Gly Tyr Val Lys Val Glu Glu Phe His Lys 
                85                  90                  95      


Met Ala Lys Glu Tyr Glu Glu Gln Leu Ser Lys Leu Asn Gly Glu Leu 
            100                 105                 110         


Glu Tyr Phe Lys Val Glu Ala Arg Ser Gly Ala Asp Gln Lys Ile Lys 
        115                 120                 125             


Glu Leu Lys Lys Asp Ile Lys Ser Leu Glu Gln Asn Val Thr Lys Leu 
    130                 135                 140                 


His Asp Arg Leu Lys Gly Ile Thr Asp Glu Leu Gly Lys Val Ser Met 
145                 150                 155                 160 


Glu Leu Cys Ser Thr Tyr Leu Glu Ser Asn Gln Leu Asp Ser Ala Lys 
                165                 170                 175     


Glu Lys Val Lys Asp Leu Pro Ser Lys Tyr Val Ile Glu Leu Val Asp 
            180                 185                 190         


Gln Phe Leu Ser Lys Asn Glu Asn Asn Trp Leu Pro Val Val Asp Leu 
        195                 200                 205             


Ser Thr Ala Val Pro Asp Leu Asp Asp Arg Gly Gln Val Tyr Lys Asn 
    210                 215                 220                 


Ile Tyr Glu Phe Leu Leu Ala Lys Ser Arg Leu Glu Gly Glu Glu Ser 
225                 230                 235                 240 


Leu Leu Leu Glu Ala Glu Ile Leu Lys Leu Asn Ala Thr Phe His Pro 
                245                 250                 255     


Gly Ser Lys Ile Thr Asp Asp Arg Lys Lys Glu Leu Asn Asp Leu Leu 
            260                 265                 270         


Glu Lys Leu Arg Gln Asn Ser Glu Lys Thr Phe Glu Gln Trp Ser Gln 
        275                 280                 285             


Glu Leu Asp Gln Ser Asn Ile Ser Ala Val Val Phe Lys Asn Ala Ile 
    290                 295                 300                 


Asp Arg Met Phe Leu Thr Gln Ile Glu Lys Phe Gly Glu Tyr Val Thr 
305                 310                 315                 320 


Gly Arg His Asp Tyr Tyr Gly Val Arg Asn Phe Leu Lys Leu Leu Gly 
                325                 330                 335     


Val Ser Lys Asn Tyr His Lys Ile Ala Ala Tyr Asn Ser Leu Val Glu 
            340                 345                 350         


Lys Lys Ile Gly His Ala Leu Ala Val Val Met Ile Asp Met Leu Ser 
        355                 360                 365             


Ile Asp Ile Ala Glu Ile Lys His Asp Pro His Val Pro Asp Arg Ile 
    370                 375                 380                 


Glu Arg Met Tyr Asn Ser Thr Ile Asn Ser Leu Pro Asp Ser Leu Lys 
385                 390                 395                 400 


Gly Ile Ile Pro Cys Ile Lys Ser Val Lys Ile Arg Asn Glu Gly Thr 
                405                 410                 415     


Asn Arg Cys Ile Tyr Ala Ile Asn Gln Asn Ile Gln Val Gln Asn Pro 
            420                 425                 430         


Asn Phe Lys Asn Ile Val Leu Gly Gln Tyr Lys Arg Val Thr Ser Thr 
        435                 440                 445             


Met Ser Ala Cys Thr Ser Phe Arg Leu Glu Leu Ser Ser Asn Lys Pro 
    450                 455                 460                 


Tyr Ile Lys Ile Ile Thr Ser Glu Gly Asn Ser Leu Thr Asn Ile Asn 
465                 470                 475                 480 


Ser Ala Val Pro Gly Glu Thr Gly Phe Ser Arg Val Gly Ala Pro Tyr 
                485                 490                 495     


Ser Asn Lys Pro Asn Met Lys Leu Asp His Thr Gly Asp Trp Val Leu 
            500                 505                 510         


Asp Ala Asn Phe Val Asn Asn Ser Ile Lys Ile Gln Ser Asp Phe Asn 
        515                 520                 525             


Ala Tyr Gln Thr Ser Lys Ser Ile Asp His Leu Val Val Arg Asn Asp 
    530                 535                 540                 


Gly Asp Val Ala Val Val Arg Tyr Gly Leu Ser Gly Met Arg Ser Gly 
545                 550                 555                 560 


Gly Ile Pro Asp Asn His Ala Glu Trp Lys Phe 
                565                 570     


<210>  16
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  16

Met Asn Pro Phe Thr Gln Val Phe Arg Leu Thr Val Gly Val Phe Phe 
1               5                   10                  15      


Phe Ala Phe Thr Ala Thr Ala Asp Glu Val Cys Glu Ile Pro Leu Ser 
            20                  25                  30          


Glu Leu Asn Lys Ile Glu Gln Thr Leu Thr His Ile Glu Lys Pro Ile 
        35                  40                  45              


Tyr Thr Glu Glu Ala Glu Ser Glu Thr Ser Asp Ser Asp Glu Cys Ala 
    50                  55                  60                  


Gln Met Leu Arg Gly Ile His Leu Gln Leu Arg Arg Leu Thr Gln Lys 
65                  70                  75                  80  


Tyr Lys Leu Met Asn Lys Gly Tyr Val Lys Val Glu Glu Phe His Lys 
                85                  90                  95      


Met Ala Lys Glu Tyr Glu Glu Gln Leu Ser Lys Leu Asn Gly Glu Leu 
            100                 105                 110         


Glu His Phe Lys Val Glu Ala Arg Ser Gly Ala Asp Gln Lys Ile Lys 
        115                 120                 125             


Glu Leu Lys Lys Asp Ile Gln Ala Leu Glu Gln Asn Val Thr Lys Leu 
    130                 135                 140                 


His Asp Arg Leu Lys Gly Ile Thr Asp Glu Leu Gly Lys Val Ser Met 
145                 150                 155                 160 


Glu Leu Cys Ser Thr Tyr Leu Glu Ser Asn Gln Leu Asp Ser Ala Lys 
                165                 170                 175     


Glu Lys Val Lys Asp Leu Pro Ser Lys Tyr Val Ile Glu Leu Val Asp 
            180                 185                 190         


Gln Phe Leu Ser Lys Asn Glu Asn Asn Trp Leu Pro Val Val Asp Leu 
        195                 200                 205             


Ser Thr Ala Val Pro Asp Leu Asp Asp Arg Gly Gln Val Tyr Lys Asn 
    210                 215                 220                 


Ile Tyr Glu Phe Leu Leu Ala Lys Ser Arg Leu Glu Gly Glu Glu Ser 
225                 230                 235                 240 


Leu Leu Leu Glu Ala Glu Ile Leu Lys Leu Asn Ala Thr Phe His Pro 
                245                 250                 255     


Gly Ser Lys Ile Thr Asp Asp Arg Lys Arg Glu Leu Asn Val Leu Leu 
            260                 265                 270         


Thr Lys Leu Ser Gln Phe Ser Glu Lys Thr Leu Glu Gln Trp Thr Gln 
        275                 280                 285             


Glu Leu Asn Gln Ser Asn Ile Ser Ala Val Val Phe Lys Asn Ala Ile 
    290                 295                 300                 


Asp Arg Met Phe Leu Thr Gln Ile Glu Lys Phe Gly Glu Tyr Val Thr 
305                 310                 315                 320 


Gly Arg His Asp Tyr Tyr Gly Val Arg Asn Phe Leu Lys Leu Leu Gly 
                325                 330                 335     


Val Ser Lys Asn Tyr His Lys Ile Ala Ala Tyr Asn Ser Leu Val Glu 
            340                 345                 350         


Lys Lys Ile Gly His Ala Leu Ala Val Val Met Ile Asp Met Leu Ser 
        355                 360                 365             


Ile Asp Ile Ala Glu Ile Lys His Asp Pro His Val Pro Asp Arg Ile 
    370                 375                 380                 


Glu Arg Met Tyr Asn Ser Thr Ile Asn Ser Leu Pro Asp Ser Leu Lys 
385                 390                 395                 400 


Gly Ile Ile Pro Cys Ile Lys Ser Val Lys Ile Arg Asn Glu Gly Thr 
                405                 410                 415     


Asn Arg Cys Ile Tyr Ala Ile Asn Gln Asn Ile Gln Val Gln Asn Pro 
            420                 425                 430         


Asn Phe Lys Asn Ile Val Leu Gly Gln Tyr Lys Arg Val Thr Ser Thr 
        435                 440                 445             


Met Ser Ala Cys Thr Ser Phe Arg Leu Glu Leu Ser Ser Asn Lys Pro 
    450                 455                 460                 


Tyr Ile Lys Ile Ile Thr Ser Glu Gly Asn Ser Leu Thr Asn Ile Asn 
465                 470                 475                 480 


Ser Ala Val Pro Gly Glu Thr Gly Phe Ser Arg Val Gly Ala Pro Tyr 
                485                 490                 495     


Ser Asn Lys Pro Asn Met Lys Leu Asp His Thr Gly Asp Trp Val Leu 
            500                 505                 510         


Asp Ala Asn Phe Val Asn Asn Ser Ile Lys Ile Gln Ser Asp Phe Asn 
        515                 520                 525             


Ala Tyr Gln Thr Ser Lys Ser Ile Asp His Leu Val Val Arg Asn Asp 
    530                 535                 540                 


Gly Asp Val Ala Val Val Arg Tyr Gly Leu Ser Gly Met Arg Ser Gly 
545                 550                 555                 560 


Gly Ile Pro Asp Asn His Ala Glu Trp Lys Leu Asn Ala Leu Lys 
                565                 570                 575 


<210>  17
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  17

Met Asn Ser Val Asn Arg Tyr Val Leu Cys Ile Ala Leu Ile Ala Leu 
1               5                   10                  15      


Phe Val Ala Ser Phe Thr Thr Ala Glu Glu Asn Cys Glu Ile Ser Ala 
            20                  25                  30          


Asn Glu Leu Gly Lys Ile Glu Gln Thr Leu Thr His Ile Asn Gln Pro 
        35                  40                  45              


Ile Tyr Thr Gly Asp Asp Glu Ser Glu Val Ser Asp Ser Asp Gln Cys 
    50                  55                  60                  


Ala Gln Met Leu Arg Gly Ile His Phe Gln Leu Arg Arg Leu Thr Gln 
65                  70                  75                  80  


Lys Tyr Lys Leu Met Asn Lys Gly Tyr Val Lys Ala Glu Glu Phe Ala 
                85                  90                  95      


Lys Met Ala Arg Asp Tyr Glu Asp Gln Leu Ser Val Leu Lys Asn Asp 
            100                 105                 110         


Leu Glu Gln Ser Lys Ile Gly Ala Asp Ser Ser Ala Lys Gln Lys Met 
        115                 120                 125             


Gln Glu Leu Lys Lys Asp Ile Ala Thr Leu Glu Gln Asn Val Asn Thr 
    130                 135                 140                 


Leu His Lys Asp Leu Glu Gly Ile Thr Asp Glu Leu Gly Lys Val Arg 
145                 150                 155                 160 


Met Asp Leu Cys Leu Thr Tyr Met Glu Ser Asn Gln Leu Ser Asn Ala 
                165                 170                 175     


Gln Asp Lys Val Lys Thr Leu Ala Pro Lys Tyr Leu Met Glu Leu Val 
            180                 185                 190         


Glu Gln Phe Leu Asn Lys Ser Glu Lys Asn Trp Leu Pro Val Val Asp 
        195                 200                 205             


Leu Ser Val Ala Ile Pro Asp Leu Asp Asp Arg Gly Gln Val Tyr Lys 
    210                 215                 220                 


Thr Val His Glu Phe Leu Lys Thr Lys Asn Arg Asp Gly Gly Glu Asp 
225                 230                 235                 240 


Ser Ile Leu Leu Glu Ala Glu Val Leu Lys Met Asn Ala Thr Phe His 
                245                 250                 255     


Pro Gly Ser Lys Ile Thr Glu Asp Arg Lys Lys Glu Ile Gln Asp Leu 
            260                 265                 270         


Leu Glu Lys Leu Ser Leu Thr Ser Thr Lys Ile Phe Asp Gln Trp Thr 
        275                 280                 285             


Gln Asp Leu Ala Lys Leu Glu Asn Ser Ala Val Tyr Lys Asn Ser Ile 
    290                 295                 300                 


Asp Arg Met Phe Leu Thr Gln Met Glu Lys Phe Gly Glu Arg Val Met 
305                 310                 315                 320 


Ala Lys Asp Asp Tyr Tyr Ser Leu Arg Asn Phe Leu Lys Leu Leu Val 
                325                 330                 335     


Val Ser Thr Asn Tyr Tyr Lys Ile Ala Ala Tyr Arg Lys Leu Ile Gln 
            340                 345                 350         


Glu Lys Ile Gly His Thr Leu Ala Val Leu Met Phe Asp Met Met Ser 
        355                 360                 365             


Met Glu Arg Thr Glu Leu Gln Tyr Asp Pro His Val Pro Asp Glu Val 
    370                 375                 380                 


Val Arg Met Tyr Asp Glu Ser Ile Thr Ala Leu Pro Asp Ser Leu Lys 
385                 390                 395                 400 


Asn Ile Arg Ser Cys Leu Lys Leu Val Lys Ile Tyr Asn His Val Thr 
                405                 410                 415     


Asn Gln Cys Ile Leu Ala Thr Asn Glu Val Glu Asp Val Asn Asn Ser 
            420                 425                 430         


Asn Pro Lys Phe Lys Ser Asn Val Leu Gly Arg Arg Lys Leu Val Lys 
        435                 440                 445             


Thr Ala Ser Asn Asp Cys Thr Pro Phe Arg Leu Glu Pro Ser Ala Asp 
    450                 455                 460                 


Lys Ala Ser Ile Arg Ile Ile Thr Pro Lys Gly Asp Ala Leu Thr Asn 
465                 470                 475                 480 


Ile Asn Ser Ile Gln Pro Gly Leu Ser Trp Phe Asn Arg Val Gly Ala 
                485                 490                 495     


Pro Tyr Thr Asn Asn His Asn Met Lys Leu Asp Tyr Ser Ala Asp Trp 
            500                 505                 510         


Ile Leu Asp Ala Asn Tyr Ala Asn Asp Ser Ile Lys Ile Glu Ser Glu 
        515                 520                 525             


Phe Asn Ala Tyr Gln Thr Met Lys Ser Val Asp His Leu Met Val Thr 
    530                 535                 540                 


Asn Val Gly Lys Val Pro His Val Val Val Ala Gln Tyr Gly Leu Lys 
545                 550                 555                 560 


Gly Met Glu Tyr Ala Gly Ala Gly Met Lys Asp Ala Glu Trp Lys Phe 
                565                 570                 575     


Lys Cys Asp Asn 
            580 


<210>  18
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  18

Met Lys Val Tyr Ile Cys Gln Val Ile Phe Ser Phe Leu Ala Val Ser 
1               5                   10                  15      


Val Phe Cys Glu Glu Asn Cys Asn Ile Pro Glu Ser Glu Leu Ser Lys 
            20                  25                  30          


Ile Asp His Val Leu Arg His Met Glu Lys Pro Ile Tyr Ser Glu Glu 
        35                  40                  45              


Gln Phe Ala Ser Asp Asn Glu Glu Cys Thr Asn Leu Leu Asn Gly Ile 
    50                  55                  60                  


His Ala Gln Leu Arg Arg Leu Thr Gln Arg Tyr Lys Leu Met Asn Lys 
65                  70                  75                  80  


Gly Tyr Val Lys Val Glu Glu Tyr Gln Arg Met Ala Asp Asn Tyr Glu 
                85                  90                  95      


Lys Gln Leu Lys Thr Leu Asn Asp Glu Leu Val Glu Leu Gln Gln His 
            100                 105                 110         


Thr Ser Glu Lys Ala Ser Ala Thr Ile Ala Lys Leu Lys Glu Asp Ile 
        115                 120                 125             


Lys Lys Leu Asp Glu Glu Val Gly Thr Leu His Glu Lys Leu Lys Gly 
    130                 135                 140                 


Ile Lys Gln Asp Phe Glu Lys Val Lys Arg Asp Leu Cys Val Thr Tyr 
145                 150                 155                 160 


Leu Asn Ser Asn Gln Met Ser Lys Ala Lys Ala Lys Leu Lys Glu Met 
                165                 170                 175     


Ala Ser Thr Tyr Leu Ile Glu Ile Val Gln Gln Gln Leu Asn Lys Ser 
            180                 185                 190         


Asn Ala Asn Ile Met Pro Met Leu Glu Phe Ser Ala Ala Ile Pro Asp 
        195                 200                 205             


Leu Asp Asp Met Gly Glu Ala Tyr Lys Glu Ile Tyr Lys Phe Leu Glu 
    210                 215                 220                 


Glu Gln Lys Arg Leu Glu Gly Glu Asp Ser Val Leu Leu Glu Ala Thr 
225                 230                 235                 240 


Val Leu Lys Met Asn Ala Ser Leu Lys Glu Gly Ser Asn Ile Thr Asp 
                245                 250                 255     


Glu Arg Arg Thr Gln Ile Glu Gly Leu Leu Lys Asp Leu Ala Thr Lys 
            260                 265                 270         


Ser Thr Ile Val Phe Ser Thr Trp Thr Lys Glu Leu Lys Lys Ile Asn 
        275                 280                 285             


Asp Ala Val Val Ile Lys Asn Ala Leu Asp His Met Phe Val Ser Gln 
    290                 295                 300                 


Met Lys Val Phe Gly Ala Leu Val Gly Asp Thr Ser Asp Phe Gly Ser 
305                 310                 315                 320 


Ile Arg Asn Phe Val Lys Leu Thr Ile Val Cys Asn Asn Tyr Tyr Lys 
                325                 330                 335     


Val Ala Ala Tyr Lys Glu Leu Ile Asp Arg Lys Ile Gly Asn Ala Leu 
            340                 345                 350         


Gly Thr Ile Met Phe Asp Leu Leu Thr Leu Glu Val Asn Glu Met Lys 
        355                 360                 365             


Phe Asp Pro His Val Pro Asp Glu Ile Pro Lys Leu Phe Glu Ala Thr 
    370                 375                 380                 


Leu Ser Ser Leu Pro Asn Ser Leu Thr Glu Leu Arg Thr Cys Leu Gly 
385                 390                 395                 400 


Lys Val Gln Ile Tyr Asn Lys Lys Thr Asn Lys Cys Val Val Ala Thr 
                405                 410                 415     


Gly Asn Asp Phe Asp Val His Lys Asp Lys Leu Gly Asp Phe Tyr Arg 
            420                 425                 430         


Val Val Val Ala Asp Tyr Gly Cys Thr Ser Phe Arg Leu Glu Ala Ser 
        435                 440                 445             


Gly Asp Lys Ala Ser Val Arg Ile Val Thr Pro Ser Gly Asn Pro Met 
    450                 455                 460                 


Ser Asn Val Asn Leu His Leu Glu Gly Asn Ser Leu His Asn Tyr Val 
465                 470                 475                 480 


Ala Thr Pro Lys Ser Asn Lys Pro Asp Arg Thr Pro Ser Ser Ser Asp 
                485                 490                 495     


Glu Trp Ile Leu Asp Ala Asn Tyr Asn Asn Asp Thr Ile Lys Ile Glu 
            500                 505                 510         


Ser Gln Phe Ser Asp Tyr Lys Thr Lys Lys Thr Glu Val Asp His Leu 
        515                 520                 525             


Leu Val Arg Asp Ile Asn His Leu Pro His Val Leu Val Ala Arg Tyr 
    530                 535                 540                 


Gly Phe Met Gly Leu Lys Asn Ser Asp Ala Lys Asp Thr Ile Glu Trp 
545                 550                 555                 560 


Asn Leu Lys Cys Gly Ser 
                565     


<210>  19
<211>  567
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  19

Met Lys Trp Ser Val Tyr Ile Ala Leu Leu Val Phe Ala Phe Leu Thr 
1               5                   10                  15      


Ser Pro Val Phe Ser Glu Glu Asn Cys Asn Ile Pro Glu Ser Glu Leu 
            20                  25                  30          


Ser Lys Ile Asp Asp Val Leu Arg His Met Glu Lys Pro Ile Tyr Ser 
        35                  40                  45              


Glu Asp His Tyr Thr Ser Asn Asn Glu Glu Cys Thr Asn Leu Leu Asn 
    50                  55                  60                  


Gly Ile His Ala Gln Leu Arg Arg Leu Thr Gln Arg Tyr Lys Leu Met 
65                  70                  75                  80  


Asn Lys Gly Tyr Val Lys Val Glu Glu Tyr Lys Arg Met Ala Glu Asp 
                85                  90                  95      


Tyr Glu Asn Gln Leu Lys Thr Leu Asn Ala Glu Leu Leu Glu Leu Gln 
            100                 105                 110         


Glu His Thr Ser Asp Lys Ala Asn Ala Ala Ile Ala Lys Leu Lys Glu 
        115                 120                 125             


Asp Ile Lys Lys Leu Asp Glu Asp Val Asp Thr Leu His Asn Lys Leu 
    130                 135                 140                 


Lys Gly Ile Lys Gln Asp Phe Glu Lys Val Lys Arg Asp Leu Cys Leu 
145                 150                 155                 160 


Thr Tyr Leu Asn Ser Asn Gln Met Ser Asn Ala Lys Ala Lys Val Lys 
                165                 170                 175     


Glu Met Ala Ser Thr Tyr Leu Ile Glu Ile Ile Gln Gln Arg Leu Asn 
            180                 185                 190         


Thr Lys Tyr Ala Asn Ile Ile Pro Met Leu Asp Phe Ser Thr Ala Ile 
        195                 200                 205             


Pro Asp Leu Asp Asp Arg Gly Glu Ala Tyr Lys Glu Ile Tyr Lys Phe 
    210                 215                 220                 


Ile Glu Thr His Glu Arg Leu Asp Gly Glu Asp Ala Val Leu Leu Glu 
225                 230                 235                 240 


Ala Ser Leu Leu Lys Met Asn Ala Thr Leu Lys Glu Gly Ser Asn Ile 
                245                 250                 255     


Thr Asp Glu Arg Arg Thr Glu Ile Glu Lys Met Leu Lys Glu Leu Ala 
            260                 265                 270         


Glu Lys Ser Ala Val Val Phe Lys Thr Trp Ser Thr Glu Leu Lys Gly 
        275                 280                 285             


Ile Glu Asp Thr Ile Ile Lys Tyr Ala Leu Asp His Leu Phe Val Asn 
    290                 295                 300                 


Gln Met Lys Val Phe Gly Gly Ile Val Gly Asp Thr Phe Glu Phe Ala 
305                 310                 315                 320 


Pro Ile Arg His Leu Leu Lys Leu Leu Val Val Cys Asn Asn Tyr Tyr 
                325                 330                 335     


Lys Val Ala Ala Tyr Lys Glu Leu Ile Asp Arg Lys Ile Gly Asn Val 
            340                 345                 350         


Leu Gly Thr Ile Met Phe Asp Leu Thr Thr Leu Glu Ala Asn Glu Met 
        355                 360                 365             


Ser Phe Asp Leu His Val Pro Asp Glu Ile Pro Lys Leu Phe Asn Ala 
    370                 375                 380                 


Thr Leu Gly Ser Leu Pro Asn Ser Leu Thr Gln Leu Leu Pro Cys Leu 
385                 390                 395                 400 


Asn Lys Val His Val Tyr Asn Ala Lys Thr Asn Met Cys Ile Val Ala 
                405                 410                 415     


Pro Glu Asp Arg Phe Asp Val Gln Gln Glu Lys Leu Thr Asp Phe His 
            420                 425                 430         


Arg Val Val Leu Ala Lys Tyr Gly Cys Thr Ala Phe Arg Leu Glu Ser 
        435                 440                 445             


Ser Pro Asn Lys Ala Ser Val Lys Phe Val Lys Pro Ser Gly Asn Ala 
    450                 455                 460                 


Leu Ser Ser Ile Asn Leu Gln Leu Glu Asn Asp Gln Trp His Ser His 
465                 470                 475                 480 


Val Gly Thr Pro Thr Ala Asn Lys Pro Asp Arg Lys Pro Ser Ser Ser 
                485                 490                 495     


Asp Glu Trp Ile Leu Asp Ala Asn Tyr Val Asn Asp Thr Val Lys Ile 
            500                 505                 510         


Gln Ser Glu Phe Asn Glu Tyr Lys Ala Ser Gln Ala Glu Val Asp His 
        515                 520                 525             


Leu Leu Val Met Asp Val Lys Tyr Leu Pro His Val Val Val Gly Arg 
    530                 535                 540                 


Tyr Gly Val Arg Gly Leu Lys Arg Ser Ser Ala Lys Asp Thr Ile Glu 
545                 550                 555                 560 


Trp Tyr Leu Lys Cys Ala Ser 
                565         


<210>  20
<211>  321
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein D7

<400>  20

Met Lys Leu Pro Leu Leu Leu Ala Ile Val Thr Thr Phe Ser Val Val 
1               5                   10                  15      


Ala Ser Thr Gly Pro Phe Asp Pro Glu Glu Met Leu Phe Thr Phe Thr 
            20                  25                  30          


Arg Cys Met Glu Asp Asn Leu Glu Asp Gly Pro Asn Arg Leu Pro Met 
        35                  40                  45              


Leu Ala Lys Trp Lys Glu Trp Ile Asn Glu Pro Val Asp Ser Pro Ala 
    50                  55                  60                  


Thr Gln Cys Phe Gly Lys Cys Val Leu Val Arg Thr Gly Leu Tyr Asp 
65                  70                  75                  80  


Pro Val Ala Gln Lys Phe Asp Ala Ser Val Ile Gln Glu Gln Phe Lys 
                85                  90                  95      


Ala Tyr Pro Ser Leu Gly Glu Lys Ser Lys Val Glu Ala Tyr Ala Asn 
            100                 105                 110         


Ala Val Gln Gln Leu Pro Ser Thr Asn Asn Asp Cys Ala Ala Val Phe 
        115                 120                 125             


Lys Ala Tyr Asp Pro Val His Lys Ala His Lys Asp Thr Ser Lys Asn 
    130                 135                 140                 


Leu Phe His Gly Asn Lys Glu Leu Thr Lys Gly Leu Tyr Glu Lys Leu 
145                 150                 155                 160 


Gly Lys Asp Ile Arg Gln Lys Lys Gln Ser Tyr Phe Glu Phe Cys Glu 
                165                 170                 175     


Asn Lys Tyr Tyr Pro Ala Gly Ser Asp Lys Arg Gln Gln Leu Cys Lys 
            180                 185                 190         


Ile Arg Gln Tyr Thr Val Leu Asp Asp Ala Leu Phe Lys Glu His Thr 
        195                 200                 205             


Asp Cys Val Met Lys Gly Ile Arg Tyr Ile Thr Lys Asn Asn Glu Leu 
    210                 215                 220                 


Asp Ala Glu Glu Val Lys Arg Asp Phe Met Gln Val Asn Lys Asp Thr 
225                 230                 235                 240 


Lys Ala Leu Glu Lys Val Leu Asn Asp Cys Lys Ser Lys Glu Pro Ser 
                245                 250                 255     


Asn Ala Gly Glu Lys Ser Trp His Tyr Tyr Lys Cys Leu Val Glu Ser 
            260                 265                 270         


Ser Val Lys Asp Asp Phe Lys Glu Ala Phe Asp Tyr Arg Glu Val Arg 
        275                 280                 285             


Ser Gln Ile Tyr Ala Phe Asn Leu Pro Lys Lys Gln Val Tyr Ser Lys 
    290                 295                 300                 


Pro Ala Val Gln Ser Gln Val Met Glu Ile Asp Gly Lys Gln Cys Pro 
305                 310                 315                 320 


Gln 
    


<210>  21
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein D7

<400>  21

Met Asn Ile Leu Leu Val Leu Ala Val Val Thr Ile Ser Ser Leu Ala 
1               5                   10                  15      


Leu Val Thr Ala Lys Gly Pro Phe Asp Pro Glu Glu Met His Phe Ile 
            20                  25                  30          


Phe Thr Arg Cys Met Glu Asp Asn Leu Lys Asp Gly Pro Asp Arg Val 
        35                  40                  45              


Lys Thr Leu Leu Lys Trp Lys Glu Trp Val Thr Glu Pro Lys Asp Asp 
    50                  55                  60                  


Pro Ala Thr His Cys Phe Ala Lys Cys Val Leu Glu Met Ser Gly Leu 
65                  70                  75                  80  


Tyr Asp Ala Ala Ser Gly Lys Phe Asp Ala Ser Val Ile Glu Ala Gln 
                85                  90                  95      


His Lys Ala Tyr Pro Asn Ser Glu Asp Lys Gly Lys Val Asp Ala Phe 
            100                 105                 110         


Val Lys Ala Val Gln Ala Leu Pro Pro Thr Lys Asn Asp Cys Thr Ala 
        115                 120                 125             


Val Phe Arg Ala Phe Gly Pro Val His Met Ala His Lys Ala Thr Ser 
    130                 135                 140                 


Ile Asn Leu Phe His Asp Asn Lys Ala Leu Thr Lys Gly Ile Tyr Glu 
145                 150                 155                 160 


Lys Leu Gly Lys Asp Ile Arg Gln Arg Lys Gln Ser Tyr Phe Glu Phe 
                165                 170                 175     


Cys Glu Asn Lys His Tyr Pro Val Gly Ser Pro Lys Arg Ser Asp Leu 
            180                 185                 190         


Cys Lys Ile Arg Gln Tyr Val Val Leu Asp Asp Ala Gln Phe Lys Gln 
        195                 200                 205             


His Thr Asp Cys Ile Met Lys Gly Leu Arg Tyr Ile Thr Lys Asp Asn 
    210                 215                 220                 


Ile Leu Asn Cys Asp Glu Ile Lys Arg Asp Phe Lys Gln Val Asn Lys 
225                 230                 235                 240 


Asp Thr Gly Ala Leu Glu Lys Val Leu Asn Thr Cys Lys Ala Lys Glu 
                245                 250                 255     


Pro Arg Asp Val Lys Glu Lys Ser Trp His Tyr Tyr Lys Cys Leu Val 
            260                 265                 270         


Glu Ser Ser Val Ala Asn Asp Phe Lys Glu Ala Phe Asp Tyr Arg Glu 
        275                 280                 285             


Val Arg Ser Gln Asn Tyr Gly Tyr His Leu Met Gln Lys Gln Pro Tyr 
    290                 295                 300                 


Asn Lys Pro Ala Val Gln Ala Gln Val Ser Glu Val Asp Gly Lys Gln 
305                 310                 315                 320 


Cys Pro Ser 
            


<210>  22
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  22

Met Lys Pro Leu Val Lys Leu Phe Leu Leu Phe Cys Leu Val Gly Ile 
1               5                   10                  15      


Val Leu Ser Arg Pro Met Pro Glu Asp Glu Glu Pro Val Ala Glu Gly 
            20                  25                  30          


Gly Asp Asp Asp Ala Ser Gly Glu Ser Glu Gly Glu Glu Glu Thr Thr 
        35                  40                  45              


Asp Asp Ala Gly Gly Asp Gly Gly Glu Glu Glu Asn Glu Gly Glu Glu 
    50                  55                  60                  


His Ala Gly Asp Lys Asp Ala Gly Gly Glu Asp Thr Gly Lys Glu Glu 
65                  70                  75                  80  


Asn Thr Gly His Asp Asp Ala Gly Glu Glu Asp Ala Gly Glu Glu Asp 
                85                  90                  95      


Ala Gly Glu Glu Asp Ala Gly Glu Glu Asp Ala Gly Glu Glu Asp Ala 
            100                 105                 110         


Glu Lys Glu Glu Gly Glu Lys Glu Asp Ala Gly Asp Asp Ala Gly Ser 
        115                 120                 125             


Asp Asp Gly Glu Glu Asp Ser Thr Gly Gly Asp Glu Gly Glu Asp Asn 
    130                 135                 140                 


Ala Glu Asp Ser Lys Gly Ser Glu Lys Asn Asp Pro Ala Asp Thr Tyr 
145                 150                 155                 160 


Arg Gln Val Val Ala Leu Leu Asp Lys Asp Thr Lys Val Asp His Ile 
                165                 170                 175     


Gln Ser Glu Tyr Leu Arg Ser Ala Leu Asn Asn Asp Leu Gln Ser Glu 
            180                 185                 190         


Val Arg Val Pro Val Val Glu Ala Ile Gly Arg Ile Gly Asp Tyr Ser 
        195                 200                 205             


Lys Ile Gln Gly Cys Phe Lys Ser Met Gly Lys Asp Val Lys Lys Val 
    210                 215                 220                 


Ile Ser Glu Glu Glu Lys Lys Phe Lys Ser Cys Met Ser Lys Lys Lys 
225                 230                 235                 240 


Ser Glu Tyr Gln Cys Ser Glu Asp Ser Phe Ala Ala Ala Lys Ser Lys 
                245                 250                 255     


Leu Ser Pro Ile Thr Ser Lys Ile Lys Ser Cys Val Ser Ser Lys Arg 
            260                 265                 270         


<210>  23
<211>  258
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  23

Met Lys Pro Leu Val Lys Leu Phe Leu Leu Phe Cys Leu Val Gly Ile 
1               5                   10                  15      


Val Leu Ser Arg Pro Met Pro Glu Asp Glu Glu Pro Val Ala Glu Gly 
            20                  25                  30          


Gly Asp Glu Glu Thr Thr Asp Asp Ala Gly Gly Asp Gly Gly Glu Glu 
        35                  40                  45              


Glu Asn Glu Gly Glu Glu His Ala Gly Asp Glu Asp Ala Gly Gly Glu 
    50                  55                  60                  


Asp Thr Gly Lys Glu Glu Asn Thr Gly His Glu Asp Ala Gly Glu Glu 
65                  70                  75                  80  


Asp Ala Gly Glu Glu Asp Ala Gly Glu Glu Asp Ala Gly Glu Glu Asp 
                85                  90                  95      


Ala Glu Lys Glu Glu Gly Glu Lys Glu Asp Ala Gly Asp Asp Ala Gly 
            100                 105                 110         


Ser Asp Asp Gly Glu Glu Asp Ser Thr Gly Gly Asp Glu Gly Glu Ala 
        115                 120                 125             


Asn Ala Glu Asp Ser Lys Gly Ser Glu Lys Asn Asp Pro Ala Asp Thr 
    130                 135                 140                 


Tyr Arg Gln Val Val Ala Leu Leu Asp Lys Asp Thr Lys Val Asp His 
145                 150                 155                 160 


Ile Gln Ser Glu Tyr Leu Arg Ser Ala Leu Asn Asn Asp Leu Gln Ser 
                165                 170                 175     


Glu Val Arg Val Pro Val Val Glu Ala Ile Gly Arg Ile Gly Asp Tyr 
            180                 185                 190         


Ser Lys Ile Gln Gly Cys Phe Lys Ser Met Gly Lys Asp Val Lys Lys 
        195                 200                 205             


Val Ile Ser Glu Glu Glu Lys Lys Phe Lys Ser Cys Met Ser Lys Lys 
    210                 215                 220                 


Lys Ser Glu Tyr Gln Cys Ser Glu Asp Ser Phe Ala Ala Ala Lys Ser 
225                 230                 235                 240 


Lys Leu Ser Pro Ile Thr Ser Lys Ile Lys Ser Cys Val Ser Ser Lys 
                245                 250                 255     


Gly Arg 
        


<210>  24
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  24

Met Lys Tyr Leu Leu Thr Phe Leu Met Ala Leu Ser Leu Val Asn Leu 
1               5                   10                  15      


Met Leu Thr Arg Pro Thr Pro Glu Asp Asp Gly Gly Thr Ser Glu Glu 
            20                  25                  30          


Pro Gln Thr Gln Glu Thr Thr Gly Ser Asp Glu Lys Asn Gly Ala Ser 
        35                  40                  45              


Glu Glu Pro Asn Ala Asp Asp Ala Ser Lys Pro Asp Asp Val Glu Glu 
    50                  55                  60                  


Lys Gly Asp Asp Asp Thr Ala Lys Lys Glu Asp Asp Gly Glu Ser Lys 
65                  70                  75                  80  


Asp Gly Glu Gly Ser Glu Lys Ser Asp Lys Glu Lys Gly Glu Pro Lys 
                85                  90                  95      


Asn Asp Pro Arg Glu Thr Tyr Asn Lys Val Ile Glu Gln Leu Asp Gln 
            100                 105                 110         


Ile Lys Val Asp Asn Val Glu Asp Gly His Glu Arg Ser Glu Leu Ala 
        115                 120                 125             


Ala Asp Ile Gln Arg Tyr Leu Arg Asn Pro Ile Val Asp Val Ile Gly 
    130                 135                 140                 


Ser Ala Gly Asp Phe Ser Lys Ile Ala Lys Cys Phe Lys Ser Met Val 
145                 150                 155                 160 


Gly Asp Ala Lys Lys Ala Ile Glu Glu Asp Val Lys Gly Phe Lys Glu 
                165                 170                 175     


Cys Thr Ala Lys Lys Asp Ser Asn Ala Tyr Gln Cys Ser Gln Asp Arg 
            180                 185                 190         


Ser Thr Val Gln Asp Lys Ile Ala Lys Met Ser Ser Lys Ile Ala Ser 
        195                 200                 205             


Cys Val Ala Ser Asn Arg Ser 
    210                 215 


<210>  25
<211>  204
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  25

Met Gln Leu Phe Pro Ile Ser Leu Val Val Ser Cys Leu Val Phe Ser 
1               5                   10                  15      


Phe Val Leu Ser Leu Pro Leu Pro Glu Glu Glu Ala Ser Thr Ser Glu 
            20                  25                  30          


Glu Thr Glu Ala Thr Thr Glu Ala Glu Ser Ala Ala Ala Asp Glu Thr 
        35                  40                  45              


Thr Ala Thr Gly Ala Asp Asp Ala Glu Ser Gly Ser Ser Glu Lys Asn 
    50                  55                  60                  


Asn Glu Gly Gly Glu Thr Ser Ala Pro Glu Ala Lys Glu Glu Gly Ser 
65                  70                  75                  80  


Gly Lys Asp Asp Arg Leu Asp Thr Tyr Asn Lys Val Asn Glu Leu Leu 
                85                  90                  95      


Asp Lys Gly Thr Gly Val Asn Asn Val Glu Asn Gly Phe Leu Arg Ala 
            100                 105                 110         


Phe Leu Asp Asn Asn Leu Gln Ser His Leu Arg Val Pro Val Ile Asp 
        115                 120                 125             


Ala Ile Gly Leu Val Gly Asp Phe Ser Lys Ile Ala Gly Cys Phe Thr 
    130                 135                 140                 


Ser Met Gly Ala Asp Val Lys Lys Ile Val Asp Asp Lys Leu Lys Ser 
145                 150                 155                 160 


Phe Thr Thr Cys Lys Ser Gly Lys Glu Ala Gly Asp Ala Lys Cys Ser 
                165                 170                 175     


Glu Asp Gly Ser Ser Val Gly Gly Gln Phe Asp Gln Ile Thr Ser Lys 
            180                 185                 190         


Ile Lys Glu Cys Val Ser Ser Lys Gly Lys Gly Lys 
        195                 200                 


<210>  26
<211>  209
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein

<400>  26

Met Arg Ser Leu Leu Val Leu Phe Ala Ala Leu Cys Leu Val Gly Phe 
1               5                   10                  15      


Val Leu Ala Lys Pro Ile Pro Glu Asp Asp Thr Glu Ala Thr Thr Glu 
            20                  25                  30          


Glu Pro Lys Ala Glu Asp Ala Ala Glu Gln Thr Thr Ala Glu Asp Ala 
        35                  40                  45              


Gly Gly Ser Asp Gly Glu Lys Asn Asp Asp Glu Lys Pro Ser Asp Asp 
    50                  55                  60                  


Ala Ala Ser Asn Asp Gln Pro Lys Asp Val Glu Gly Gly Glu Asp Gly 
65                  70                  75                  80  


Lys Glu Ser Pro Lys Thr Glu Gly Glu Ala Lys Asn Asp Pro Gln Glu 
                85                  90                  95      


Thr Tyr Asn Lys Val Ile Glu Leu Leu Asp Gln Ile Lys Val Asp Asn 
            100                 105                 110         


Val Glu Asn Gly Tyr Glu Arg Ser Glu Leu Thr Ser Asp Leu Gln Thr 
        115                 120                 125             


Tyr Leu Arg Asn Pro Ile Val Asp Ala Ile Thr Val Gly Asp Phe Ser 
    130                 135                 140                 


Lys Ile Ala Asp Cys Phe Lys Ser Met Gly Asp Glu Ala Lys Lys Ala 
145                 150                 155                 160 


Ile Glu Glu Glu Leu Lys Ala Phe Lys Glu Cys Thr Asp Lys Lys Glu 
                165                 170                 175     


Ser Asp Ala Tyr Gln Cys Ser Lys Asn His Ser Thr Val Gln Gly Lys 
            180                 185                 190         


Ile Ala Lys Ile Ser Ser Thr Ile Asn Ser Cys Val Val Ser Lys Arg 
        195                 200                 205             


Ala 
    


<210>  27
<211>  537
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Apyrase 5' nucleotidase

<400>  27

Met Ala Arg Leu Ser Phe Val Pro Leu Val Ile Ser Phe Leu Ser Cys 
1               5                   10                  15      


Thr Thr Ala Leu Ser Glu Lys Ser Leu Phe Pro Leu Ser Ile Ile His 
            20                  25                  30          


Val Asn Asp Ile His Ala Arg Phe Glu Glu Thr Asn Tyr Val Gly Thr 
        35                  40                  45              


Val Cys Lys Pro His Glu Gly Gln Val Cys Ile Gly Gly Tyr Ala Arg 
    50                  55                  60                  


Thr Val Thr Val Val Lys His Leu Leu Arg Ile Arg Gln Asn Pro Leu 
65                  70                  75                  80  


Tyr Leu Asn Ala Gly Asp Asn Phe Gln Gly Thr Leu Trp Tyr Asn Met 
                85                  90                  95      


Phe Arg Trp Asn Val Thr Ser Thr Phe Leu Asn Met Leu Pro Ala Asp 
            100                 105                 110         


Ala Met Thr Leu Gly Asn His Glu Phe Asp Asn Gly Val Asp Gly Val 
        115                 120                 125             


Ile Pro Phe Leu Asp Thr Ala Ser Ser Pro Val Leu Leu Cys Asn Val 
    130                 135                 140                 


Asp Ala Ser Glu Val Pro Glu Phe Val Lys Tyr Glu Lys Ser Ile Val 
145                 150                 155                 160 


Ile Glu Arg Ala Gly Arg Lys Ile Gly Ile Ile Gly Val Ile Leu Lys 
                165                 170                 175     


Asn Thr Ser Val Ile Ser Asn Pro Gly Lys Leu Arg Phe Leu Asp Glu 
            180                 185                 190         


Ala Ser Ser Val Lys Ser Glu Ala Gln Ile Leu Lys Asn Gln Gly Ile 
        195                 200                 205             


Asp Ile Ile Val Val Leu Ser His Cys Gly Val Asp Val Asp Arg Arg 
    210                 215                 220                 


Ile Ala Thr Glu Gly Gly Glu His Val Asp Ile Ile Val Gly Gly His 
225                 230                 235                 240 


Ser His Thr Phe Leu Tyr Ser Gly Asn Asn Thr Gly Ile Pro Gly Thr 
                245                 250                 255     


Val Gln Gly Ser Tyr Pro Thr Val Val Thr His Ala Ser Gly His Lys 
            260                 265                 270         


Val Leu Ile Val His Ala Ala Ala Tyr Thr Lys Leu Val Gly Asp Ile 
        275                 280                 285             


Val Leu Tyr Phe Asp Glu Gln Gly Ile Ile Gln Arg Trp Glu Gly Asn 
    290                 295                 300                 


Pro His Tyr Leu Asp Pro Glu Val Val Pro Asp Pro Glu Val His Lys 
305                 310                 315                 320 


Ala Leu Leu Pro Trp Lys Leu Ala Val Asp Glu Leu Gly Asn Arg Ile 
                325                 330                 335     


Ile Gly Thr Thr Ile Thr Asp Leu Pro Arg Leu Gly Cys Asn Tyr Arg 
            340                 345                 350         


Glu Cys Ala Leu Gly Asn Leu Ile Ser Asp Ala Phe Val Asp Ser Ser 
        355                 360                 365             


Ala Tyr Met Ala Glu Pro Gly His Trp Ser Tyr Ala Ser Ile Gly Leu 
    370                 375                 380                 


Thr Asn Thr Gly Gly Ile Arg Val Gly Leu Ser Lys Gly Asp Ile Ser 
385                 390                 395                 400 


Tyr Lys Ser Leu Ile Glu Val Ile Pro Phe Glu Asn Thr Val Asp Phe 
                405                 410                 415     


Ile Glu Leu Arg Gly Asp His Leu Leu Arg Val Leu Glu His Gly Thr 
            420                 425                 430         


Ala Lys Ser Asn Ile Gln Ile Ser Gly Leu Arg Val Val Tyr Asn Met 
        435                 440                 445             


Thr Glu Pro Tyr Gly Asn Arg Val Lys Ser Val Gln Ala Arg Cys His 
    450                 455                 460                 


Gly Cys Ser Glu Pro Arg Phe Asp Pro Leu Asp Pro Phe Lys Tyr Tyr 
465                 470                 475                 480 


Arg Val Ala Val Asn Ser His Met Ala Gly Gly Gly Gly Gly Phe Thr 
                485                 490                 495     


Met Phe Glu Glu Phe Gly Arg Asn Lys Val Val Gly Asp Val Glu Ile 
            500                 505                 510         


Asn Ala Leu Val Arg Phe Val Gln Lys Arg Ser Pro Leu Arg Tyr Glu 
        515                 520                 525             


Val Glu Gly Arg Val Thr Val Leu Asn 
    530                 535         


<210>  28
<211>  537
<212>  PRT
<213>  Artificial sequence

<220>
<223>  apyrase 5' nucleotidase

<400>  28

Met Ala Arg Leu Ser Phe Val Leu Leu Val Leu Leu Phe Leu Thr Tyr 
1               5                   10                  15      


Met Thr Val Ile Ala Glu Lys Pro Leu Phe Pro Leu Ser Ile Ile His 
            20                  25                  30          


Val Asn Asp Ile His Ala Arg Phe Glu Glu Thr Asn Tyr Val Gly Thr 
        35                  40                  45              


Val Cys Lys Pro His Glu Gly Gln Val Cys Ile Gly Gly Tyr Ala Arg 
    50                  55                  60                  


Thr Val Thr Val Val Lys His Leu Leu Arg Ile Arg Gln Asn Pro Leu 
65                  70                  75                  80  


Tyr Leu Asn Ala Gly Asp Asn Phe Gln Gly Thr Leu Trp Tyr Asn Met 
                85                  90                  95      


Phe Arg Trp Asn Val Thr Ser Thr Phe Leu Asn Met Leu Pro Ala Asp 
            100                 105                 110         


Ala Met Thr Leu Gly Asn His Glu Phe Asp Asn Gly Val Asp Gly Val 
        115                 120                 125             


Ile Pro Phe Leu Asp Thr Val Ser Ser Pro Val Leu Leu Cys Asn Val 
    130                 135                 140                 


Asp Ala Ser Glu Glu Pro Glu Phe Val Lys Tyr Glu Lys Ser Ile Val 
145                 150                 155                 160 


Ile Glu Arg Ala Gly Arg Lys Ile Gly Ile Ile Gly Val Ile Leu Lys 
                165                 170                 175     


Asn Thr Ser Val Ile Ser Asn Pro Gly Lys Leu Arg Phe Leu Asp Glu 
            180                 185                 190         


Ala Ser Ser Val Lys Ser Glu Ala His Ile Leu Lys Asp Gln Gly Ile 
        195                 200                 205             


Asp Ile Ile Val Val Leu Ser His Cys Gly Val Asp Val Asp Arg Arg 
    210                 215                 220                 


Ile Ala Thr Glu Gly Gly Glu His Val Asp Ile Ile Val Gly Gly His 
225                 230                 235                 240 


Ser His Thr Phe Leu Tyr Ser Gly Asn Asn Thr Gly Ile Pro Gly Thr 
                245                 250                 255     


Val Gln Gly Ser Tyr Pro Ile Val Val Thr His Ala Ser Gly His Lys 
            260                 265                 270         


Val Leu Ile Val Gln Ala Ala Ala Tyr Thr Lys Leu Val Gly Asp Ile 
        275                 280                 285             


Val Leu Tyr Phe Asp Glu Gln Gly Ile Ile Gln Arg Trp Glu Gly Asn 
    290                 295                 300                 


Pro His Tyr Leu Asp Pro Glu Val Val Pro Asp Pro Glu Val His Lys 
305                 310                 315                 320 


Ala Leu Leu Pro Trp Lys Leu Ala Val Asp Glu Leu Gly Asn Arg Ile 
                325                 330                 335     


Ile Gly Thr Thr Met Thr Gly Leu Pro Arg Leu Asn Cys Asn Tyr Arg 
            340                 345                 350         


Glu Cys Ala Leu Gly Asn Leu Ile Ser Asp Ala Phe Val Asp Ser Ser 
        355                 360                 365             


Ala Tyr Met Ala Glu Pro Gly His Trp Ser Tyr Ala Ser Ile Gly Leu 
    370                 375                 380                 


Thr Asn Thr Gly Gly Ile Arg Val Gly Leu Ser Lys Gly Asp Ile Ser 
385                 390                 395                 400 


Tyr Lys Ser Leu Ile Glu Val Ile Pro Phe Glu Asn Thr Val Asp Phe 
                405                 410                 415     


Ile Glu Leu Arg Gly Asp His Leu Leu Arg Val Leu Glu His Gly Thr 
            420                 425                 430         


Ala Lys Ser Asn Ile Gln Ile Ser Gly Leu Arg Val Val Tyr Asn Met 
        435                 440                 445             


Thr Glu Pro Tyr Gly Asn Arg Val Lys Ser Val Gln Ala Arg Cys His 
    450                 455                 460                 


Asp Cys Ser Glu Pro Arg Phe Asp Pro Leu Asp Pro Phe Lys Tyr Tyr 
465                 470                 475                 480 


Arg Val Ala Val Asn Ser His Met Ala Gly Gly Gly Gly Gly Phe Thr 
                485                 490                 495     


Met Phe Glu Glu Phe Gly Arg Asn Lys Val Val Gly Asp Val Glu Ile 
            500                 505                 510         


Asn Ala Leu Val Arg Phe Val Gln Lys Arg Ser Pro Leu Arg Tyr Glu 
        515                 520                 525             


Val Glu Gly Arg Val Thr Val Leu Asn 
    530                 535         


<210>  29
<211>  552
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Apyrase 5' nucleotidase

<400>  29

Met Leu Arg Thr Ser Ser Ile Val Phe Leu Thr Cys Cys Leu Thr Phe 
1               5                   10                  15      


Leu Ile Glu Gly Ser Ser Phe Lys Leu Lys Ile Ile His Phe Asn Asp 
            20                  25                  30          


Ile His Ala Arg Phe Asp Glu Val Thr Asn Ser Ser Ser Pro Cys Ser 
        35                  40                  45              


Gly Asn Gly Glu Thr Cys Val Ala Gly Ile Ala Arg Leu Val Thr Thr 
    50                  55                  60                  


Ile Glu Lys Leu Arg Lys Gln Asn Glu Asn His Leu Val Leu Asn Ala 
65                  70                  75                  80  


Gly Asp Val Phe Gln Gly Thr Ile Trp Tyr Thr Leu Leu Lys Trp Asn 
                85                  90                  95      


Val Ser Gln Gln Phe Met Asn Met Val Lys Ala Asp Ala Met Thr Leu 
            100                 105                 110         


Gly Asn His Glu Phe Asp Asp Ser Phe Pro Val Leu Ile Pro Phe Leu 
        115                 120                 125             


Glu Asn Thr Lys Asn Val Thr Pro Val Val Val Ser Asn Leu Val Phe 
    130                 135                 140                 


Pro Lys Gln Leu Ser Arg Asp Val Thr Lys Phe Arg Ser Leu Ile Lys 
145                 150                 155                 160 


Glu Asp Pro Leu Val Leu Thr Val Gly Gly Gln Ser Ile Gly Ile Ile 
                165                 170                 175     


Gly Val Ile Phe Asp Glu Thr Asp Lys Ile Gly Asn Ala Asp Pro Leu 
            180                 185                 190         


Lys Phe Lys Ser Ser Ile Glu Thr Val Arg Ile Ala Ala Lys Gln Leu 
        195                 200                 205             


Lys Ser Lys Gly Val Asn Ile Ile Ile Val Leu Ser His Cys Gly Val 
    210                 215                 220                 


Phe Asp Asp Lys Lys Ile Ala Glu Gln Ala Gly Glu Asp Ile Asp Ile 
225                 230                 235                 240 


Ile Val Gly Gly His Thr His Thr Leu Leu Tyr Asn Gly Asp Pro Pro 
                245                 250                 255     


Ser Lys His Ala Ala Leu Asp Lys Tyr Pro Ile Val Val Glu Thr Gly 
            260                 265                 270         


Asn Asn His Lys Val Leu Ile Val Gln Ala Phe Cys His Gly His Tyr 
        275                 280                 285             


Val Gly Asn Ile Asp Leu Thr Phe Asp Asp Glu Gly Glu Ile Thr Ala 
    290                 295                 300                 


Phe Glu Gly Gln Pro Ile Tyr Gln Glu Asn Arg Ile Glu Lys Asn Ala 
305                 310                 315                 320 


Leu Val Glu Ala Arg Val Arg Glu Leu Arg Lys Asp Val Glu Val Lys 
                325                 330                 335     


Ser Leu Val Lys Val Gly Glu Ser Lys Leu Glu Leu Ser Asn Asp Cys 
            340                 345                 350         


Arg Leu Lys Asp Cys Thr Phe Gly Ser Val Leu Ala Asp Ala Tyr Val 
        355                 360                 365             


Trp His Phe Arg Ser Arg Ser Asn Ala Pro Met Ile Ala Met Ile His 
    370                 375                 380                 


Pro Gly Asn Phe Arg Ile Ser Leu Ala Ala Gly Val Ile Thr Arg Gly 
385                 390                 395                 400 


Gln Ile Leu Thr Ala Leu Pro Phe Asn Ser Asn Ala Asn Arg Val Thr 
                405                 410                 415     


Val Leu Gly Ser Thr Ile Lys Lys Ala Ile Glu Phe Gly Thr Ser Ile 
            420                 425                 430         


Asn Pro Arg Arg Cys Ser Phe Asn Ala Leu Gln Thr Ala Gly Ile Lys 
        435                 440                 445             


Ile Asp Val Asp Tyr Gly Lys Pro Val Gly Asn Arg Thr Val Ile Leu 
    450                 455                 460                 


Leu Lys Thr Gly Gly Lys Tyr Lys Arg Leu Val Glu Ser Lys Lys Tyr 
465                 470                 475                 480 


Asp Ile Leu Val Asn Ser Tyr Val Phe Lys Gly Gly Asp Gly Phe Asp 
                485                 490                 495     


Met Phe Lys His Leu Ala Val Lys Gly Arg Ala Pro Phe Asp Ala Glu 
            500                 505                 510         


Leu Leu Glu Gln Tyr Ile Val Ala Arg Lys Gly Ile Gln Lys Ser Gly 
        515                 520                 525             


Leu Leu Gln Ser Arg Met Asn Val Ser His Val Glu Lys Ala Leu Ser 
    530                 535                 540                 


Glu Val Lys Ser Cys Lys Gln Arg 
545                 550         


<210>  30
<211>  564
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Apyrase 5' nucleotidase

<400>  30

Met Ala Gly Lys Pro Gly Ile Gln Leu Phe Val Ile Phe Ile Leu Leu 
1               5                   10                  15      


Ser Ser Phe Ala Ala Val Val Trp Thr Thr Asp Asn Met Pro Ala Asp 
            20                  25                  30          


Lys Asp Val Ser Lys Leu Phe Pro Leu Thr Leu Ile His Ile Asn Asp 
        35                  40                  45              


Leu His Ala Arg Phe Asp Glu Thr Asn Met Lys Ser Asn Ala Cys Thr 
    50                  55                  60                  


Ala Lys Asp Gln Cys Ile Ala Gly Ile Ala Arg Val Tyr Gln Lys Ile 
65                  70                  75                  80  


Gln Asp Leu Leu Lys Glu Tyr Lys Ser Lys Asn Ala Ile Tyr Leu Asn 
                85                  90                  95      


Ala Gly Asp Asn Phe Gln Gly Thr Leu Trp Tyr Asn Leu Leu Arg Trp 
            100                 105                 110         


Gln Val Thr Ala Asp Phe Ile Thr Lys Leu Lys Pro Thr Ala Met Thr 
        115                 120                 125             


Leu Gly Asn His Glu Phe Asp His Thr Pro Lys Gly Leu Ala Pro Tyr 
    130                 135                 140                 


Leu Ala Glu Leu Asp Lys Ala Gly Ile Pro Thr Leu Val Ala Asn Leu 
145                 150                 155                 160 


Val Met Asn Asp Asp Pro Asp Leu Lys Ser Ser Lys Ile Gln Lys Ser 
                165                 170                 175     


Ile Lys Val Thr Val Gly Gly Lys Thr Ile Gly Ile Ile Gly Val Leu 
            180                 185                 190         


Tyr Asp Lys Thr His Glu Ile Ala Gln Thr Gly Lys Val Thr Leu Ser 
        195                 200                 205             


Asn Ala Val Glu Thr Val Lys Arg Glu Ala Ala Ala Leu Lys Lys Asp 
    210                 215                 220                 


Lys Val Asp Ile Ile Val Val Leu Ser His Cys Ser Tyr Asp Glu Asp 
225                 230                 235                 240 


Lys Lys Ile Ala Lys Glu Ala Gly Gln Asp Ile Asp Val Ile Val Gly 
                245                 250                 255     


Ala His Ser His Ser Phe Leu Tyr Ser Lys Glu Ser Asn Lys Pro Tyr 
            260                 265                 270         


Asp Gln Lys Asp Lys Ile Glu Gly Pro Tyr Pro Thr Ile Val Glu Ser 
        275                 280                 285             


Asn Asn Lys Arg Lys Ile Pro Ile Val Gln Ala Lys Ser Phe Gly Lys 
    290                 295                 300                 


Tyr Val Gly Arg Leu Thr Leu Tyr Phe Asp Asn Glu Gly Glu Val Lys 
305                 310                 315                 320 


His Trp Glu Gly Tyr Pro Glu Phe Ile Asp Asn Lys Val Lys Gln Asp 
                325                 330                 335     


Pro Lys Ile Leu Glu Ala Leu Ile Pro Trp Arg Lys Lys Val Gln Glu 
            340                 345                 350         


Ile Gly Ser Thr Lys Val Gly Glu Thr Thr Ile Glu Leu Asp Arg Asp 
        355                 360                 365             


Ser Cys Arg Asp Lys Glu Cys Thr Leu Gly Val Leu Tyr Ala Asp Ala 
    370                 375                 380                 


Phe Ala Asp His Tyr Thr Asn Ser Ser Phe Arg Pro Phe Ala Ile Ile 
385                 390                 395                 400 


Gln Ala Gly Asn Phe Arg Asn Pro Ile Lys Val Gly Lys Ile Thr Asn 
                405                 410                 415     


Gly Asp Ile Ile Glu Ala Ala Pro Phe Gly Ser Thr Ala Asp Leu Ile 
            420                 425                 430         


Arg Leu Lys Gly Asp Ser Leu Trp Ala Val Ala Glu His Ser Phe Ala 
        435                 440                 445             


Leu Asp Asp Glu Asn Arg Thr Asn Cys Leu Gln Val Ser Gly Leu Arg 
    450                 455                 460                 


Ile Val Ile Asp Pro Ser Lys Lys Ile Gly Ser Arg Val Val Lys Ile 
465                 470                 475                 480 


Asp Val Met Asp Asn Arg Asn Pro Lys Ser Glu Asp Leu Lys Pro Leu 
                485                 490                 495     


Asp Lys Asn Ala Glu Tyr Phe Ile Ala Leu Pro Ser Tyr Leu Ala Asp 
            500                 505                 510         


Gly Lys Asp Gly Phe Ser Ala Met Lys Lys Ala Thr Ala Arg Trp Thr 
        515                 520                 525             


Gly Pro Leu Asp Ser Asp Val Phe Lys Ser Tyr Val Glu Lys Ile Lys 
    530                 535                 540                 


Lys Val Asp Lys Leu Lys Trp Gly Arg Val Ile Val Cys Lys Ala Gly 
545                 550                 555                 560 


Ser Pro Cys Thr 
                


