                         SEQUENCE LISTING

<110>  UCB Pharma SA
       Adams, Ralph
       Dave, Emma
 
<120>  Multivalent Antibodies

<130>  G0118-WO01

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  1

Asp Lys Thr His Thr Cys Ala Ala 
1               5               


<210>  2
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  2

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10      


<210>  3
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  4
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  5
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  6
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  6

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  7
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  7

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  8
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  8

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge Linker

<400>  9

Asp Lys Thr His Thr Cys Pro Ser Cys Pro Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  10

Ser Gly Gly Gly Gly Ser Glu 
1               5           


<210>  11
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  11

Asp Lys Thr His Thr Ser 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  12

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  13
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  13

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  14

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  15
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  15

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  16
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  16

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  17

Ala Ala Ala Gly Ser Gly Gly Ala Ser Ala Ser 
1               5                   10      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
1               5                   10                  15      


<210>  19
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ala Ser Ala Ser 
            20      


<210>  20
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25      


<210>  21
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25                  30      


<210>  22
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Ala Ala Ala Gly Ser Gly Xaa Ser Gly Ala Ser Ala Ser 
1               5                   10              


<210>  23
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  23

Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr Arg Arg Pro Ala Thr Thr 
1               5                   10                  15      


Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser His Tyr 
            20                  25              


<210>  24
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  24

Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr 
1               5                   10      


<210>  25
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  25

Ala Thr Thr Thr Gly Ser 
1               5       


<210>  26
<211>  499
<212>  PRT
<213>  Artificial

<220>
<223>  26gH2gamma1-CH13G4S645gH15G4S1189gH1

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro Gly Tyr 
                325                 330                 335     


Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    370                 375                 380                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
385                 390                 395                 400 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr Asp Met Ala Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala Ser Ile Thr 
            420                 425                 430         


Pro Ser Gly Gly Gly Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
    450                 455                 460                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Gly 
465                 470                 475                 480 


Tyr Thr Leu Asp Tyr Phe Glu Tyr Trp Gly Gln Gly Thr Met Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210>  27
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  27

Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Ser Pro Pro Ser Lys Glu 
1               5                   10                  15      


Ser His Lys Ser Pro 
            20      


<210>  28
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  28

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  29

Gly Gly Gly Gly Ile Ala Pro Ser Met Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  30

Gly Gly Gly Gly Lys Val Glu Gly Ala Gly Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  31

Gly Gly Gly Gly Ser Met Lys Ser His Asp Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  32

Gly Gly Gly Gly Asn Leu Ile Thr Ile Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker	

<400>  33

Gly Gly Gly Gly Val Val Pro Ser Leu Pro Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  34
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  34

Gly Gly Glu Lys Ser Ile Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  35
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  35

Arg Pro Leu Ser Tyr Arg Pro Pro Phe Pro Phe Gly Phe Pro Ser Val 
1               5                   10                  15      


Arg Pro 
        


<210>  36
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  36

Tyr Pro Arg Ser Ile Tyr Ile Arg Arg Arg His Pro Ser Pro Ser Leu 
1               5                   10                  15      


Thr Thr 
        


<210>  37
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  37

Thr Pro Ser His Leu Ser His Ile Leu Pro Ser Phe Gly Leu Pro Thr 
1               5                   10                  15      


Phe Asn 
        


<210>  38
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  38

Arg Pro Val Ser Pro Phe Thr Phe Pro Arg Leu Ser Asn Ser Trp Leu 
1               5                   10                  15      


Pro Ala 
        


<210>  39
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  39

Ser Pro Ala Ala His Phe Pro Arg Ser Ile Pro Arg Pro Gly Pro Ile 
1               5                   10                  15      


Arg Thr 
        


<210>  40
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  40

Ala Pro Gly Pro Ser Ala Pro Ser His Arg Ser Leu Pro Ser Arg Ala 
1               5                   10                  15      


Phe Gly 
        


<210>  41
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  41

Pro Arg Asn Ser Ile His Phe Leu His Pro Leu Leu Val Ala Pro Leu 
1               5                   10                  15      


Gly Ala 
        


<210>  42
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  42

Met Pro Ser Leu Ser Gly Val Leu Gln Val Arg Tyr Leu Ser Pro Pro 
1               5                   10                  15      


Asp Leu 
        


<210>  43
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  43

Ser Pro Gln Tyr Pro Ser Pro Leu Thr Leu Thr Leu Pro Pro His Pro 
1               5                   10                  15      


Ser Leu 
        


<210>  44
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  44

Asn Pro Ser Leu Asn Pro Pro Ser Tyr Leu His Arg Ala Pro Ser Arg 
1               5                   10                  15      


Ile Ser 
        


<210>  45
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  45

Leu Pro Trp Arg Thr Ser Leu Leu Pro Ser Leu Pro Leu Arg Arg Arg 
1               5                   10                  15      


Pro 
    


<210>  46
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  46

Pro Pro Leu Phe Ala Lys Gly Pro Val Gly Leu Leu Ser Arg Ser Phe 
1               5                   10                  15      


Pro Pro 
        


<210>  47
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  47

Val Pro Pro Ala Pro Val Val Ser Leu Arg Ser Ala His Ala Arg Pro 
1               5                   10                  15      


Pro Tyr 
        


<210>  48
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  48

Leu Arg Pro Thr Pro Pro Arg Val Arg Ser Tyr Thr Cys Cys Pro Thr 
1               5                   10                  15      


Pro 
    


<210>  49
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  49

Pro Asn Val Ala His Val Leu Pro Leu Leu Thr Val Pro Trp Asp Asn 
1               5                   10                  15      


Leu Arg 
        


<210>  50
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  50

Cys Asn Pro Leu Leu Pro Leu Cys Ala Arg Ser Pro Ala Val Arg Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  51
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  51

Asp Leu Cys Leu Arg Asp Trp Gly Cys Leu Trp 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  52

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  53
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  53

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Gly Asp 
1               5                   10                  15  


<210>  54
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  54

Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Glu 
            20  


<210>  55
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  55

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val 
            20  


<210>  56
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  56

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val Lys 
            20      


<210>  57
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  57

Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15  


<210>  58
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  58

Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  59
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  59

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15      


<210>  60
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  60

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10                  15  


<210>  61
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  61

Arg Leu Met Glu Asp Ile Cys Leu Ala Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  62
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  62

Glu Val Arg Ser Phe Cys Thr Arg Trp Pro Ala Glu Lys Ser Cys Lys 
1               5                   10                  15      


Pro Leu Arg Gly 
            20  


<210>  63
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  63

Arg Ala Pro Glu Ser Phe Val Cys Tyr Trp Glu Thr Ile Cys Phe Glu 
1               5                   10                  15      


Arg Ser Glu Gln 
            20  


<210>  64
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Albumin binding peptide

<400>  64

Glu Met Cys Tyr Phe Pro Gly Ile Cys Trp Met 
1               5                   10      


<210>  65
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  26 gH2

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  66
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  gamma 1 cH1

<400>  66

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  67
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  3G4S

<400>  67

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  68
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  645 gH1

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr 
                85                  90                  95      


Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  5G4S

<400>  69

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  70
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  1189 gH1

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Pro Ser Gly Gly Gly Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Tyr Thr Leu Asp Tyr Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  71
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  1G4S

<400>  71

Gly Gly Gly Gly Ser 
1               5   


<210>  72
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  2G4S

<400>  72

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  3G4S

<400>  73

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  74
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  4G4S

<400>  74

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  75
<211>  472
<212>  PRT
<213>  Artificial

<220>
<223>  26 gL8 CK 3G4S 645gL1 5G4S 1189gL1

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
                245                 250                 255     


Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
            260                 265                 270         


Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    290                 295                 300                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly 
305                 310                 315                 320 


Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys 
                325                 330                 335     


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
        355                 360                 365             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    370                 375                 380                 


Thr Ile Thr Cys Leu Ala Ser Glu Gly Ile Ser Asn Asp Leu Ala Trp 
385                 390                 395                 400 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala 
                405                 410                 415     


Thr Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            420                 425                 430         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
        435                 440                 445             


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Tyr Pro Trp Thr Phe Gly 
    450                 455                 460                 


Cys Gly Thr Lys Leu Glu Ile Lys 
465                 470         


<210>  76
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  26 gL8

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  77
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  CKappa

<400>  77

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  78
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  645 gL1

<400>  78

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  79
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  1189 gL1

<400>  79

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Gly Ile Ser Asn Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Thr Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  80
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  26Fab gH2 CH1-(3G4S)-645gH1ds-(3xG4S)-652gH2ds

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro Gly Tyr 
                325                 330                 335     


Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro 
    370                 375                 380                 


Thr Glu Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
385                 390                 395                 400 


Asn Tyr His Val Gln Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu 
                405                 410                 415     


Trp Leu Gly Val Met Trp Ser Asp Gly Asp Thr Ser Phe Asn Ser Val 
            420                 425                 430         


Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val 
        435                 440                 445             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    450                 455                 460                 


Cys Ala Arg Asp Gly Thr Ile Ala Ala Met Asp Tyr Phe Asp Tyr Trp 
465                 470                 475                 480 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490 


<210>  81
<211>  463
<212>  PRT
<213>  Artificial

<220>
<223>  26gL8 CK-(3G4S)-645gL1ds-(3xG4S)-652gL1ds

<400>  81

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
                245                 250                 255     


Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
            260                 265                 270         


Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    290                 295                 300                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly 
305                 310                 315                 320 


Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys 
                325                 330                 335     


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        355                 360                 365             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile 
    370                 375                 380                 


Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
385                 390                 395                 400 


Leu Leu Ile Tyr His Thr Ser Arg Leu Gln Asp Gly Val Pro Ser Arg 
                405                 410                 415     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            420                 425                 430         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Arg 
        435                 440                 445             


Phe Pro Leu Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg 
    450                 455                 460             


<210>  82
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  26gH2 CH1-(3G4S)-645gH1ds-(3xG4S)-652gH2

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro Gly Tyr 
                325                 330                 335     


Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro 
    370                 375                 380                 


Thr Glu Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
385                 390                 395                 400 


Asn Tyr His Val Gln Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                405                 410                 415     


Trp Leu Gly Val Met Trp Ser Asp Gly Asp Thr Ser Phe Asn Ser Val 
            420                 425                 430         


Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val 
        435                 440                 445             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    450                 455                 460                 


Cys Ala Arg Asp Gly Thr Ile Ala Ala Met Asp Tyr Phe Asp Tyr Trp 
465                 470                 475                 480 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490 


<210>  83
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  26gL8 CK-(3G4S)-645gL1ds-(3xG4S)-652gL1

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
                245                 250                 255     


Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
            260                 265                 270         


Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    290                 295                 300                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly 
305                 310                 315                 320 


Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys 
                325                 330                 335     


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        355                 360                 365             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile 
    370                 375                 380                 


Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
385                 390                 395                 400 


Leu Leu Ile Tyr His Thr Ser Arg Leu Gln Asp Gly Val Pro Ser Arg 
                405                 410                 415     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            420                 425                 430         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Arg 
        435                 440                 445             


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
    450                 455                 460         


<210>  84
<211>  488
<212>  PRT
<213>  Artificial

<220>
<223>  26gH2 CH1-(3G4S)-645gH1ds-(3xG4S)-870ds

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro Gly Tyr 
                325                 330                 335     


Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    370                 375                 380                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Val Phe Thr 
385                 390                 395                 400 


Asp Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 
                405                 410                 415     


Trp Met Gly Trp Ile Asn Thr Tyr Ile Gly Glu Pro Ile Tyr Ala Asp 
            420                 425                 430         


Ser Val Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr 
        435                 440                 445             


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    450                 455                 460                 


Tyr Cys Ala Arg Gly Tyr Arg Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
465                 470                 475                 480 


Gly Thr Leu Val Thr Val Ser Ser 
                485             


<210>  85
<211>  463
<212>  PRT
<213>  Artificial

<220>
<223>  26gL8 CK-(3G4S)-645gL1ds-(3xG4S)-870ds

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
                245                 250                 255     


Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
            260                 265                 270         


Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    290                 295                 300                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly 
305                 310                 315                 320 


Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys 
                325                 330                 335     


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        355                 360                 365             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
    370                 375                 380                 


Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
385                 390                 395                 400 


Ala Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Tyr Arg 
                405                 410                 415     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            420                 425                 430         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile 
        435                 440                 445             


Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg 
    450                 455                 460             


<210>  86
<211>  488
<212>  PRT
<213>  Artificial

<220>
<223>  26gH2 CH1-(3G4S)-645gH1ds-(3xG4S)-870

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro Gly Tyr 
                325                 330                 335     


Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    370                 375                 380                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Val Phe Thr 
385                 390                 395                 400 


Asp Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                405                 410                 415     


Trp Met Gly Trp Ile Asn Thr Tyr Ile Gly Glu Pro Ile Tyr Ala Asp 
            420                 425                 430         


Ser Val Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr 
        435                 440                 445             


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    450                 455                 460                 


Tyr Cys Ala Arg Gly Tyr Arg Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
465                 470                 475                 480 


Gly Thr Leu Val Thr Val Ser Ser 
                485             


<210>  87
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  26gL8 CK-(3G4S)-645gL1ds-(3xG4S)-870

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
                245                 250                 255     


Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
            260                 265                 270         


Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    290                 295                 300                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly 
305                 310                 315                 320 


Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys 
                325                 330                 335     


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        355                 360                 365             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
    370                 375                 380                 


Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
385                 390                 395                 400 


Ala Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Tyr Arg 
                405                 410                 415     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            420                 425                 430         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile 
        435                 440                 445             


Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    450                 455                 460         


<210>  88
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  88

Gly Ala Pro Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10      


<210>  89
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  89

Pro Pro Pro Pro 
1               


