                         SEQUENCE LISTING

<110>  Chen, Qiang
       Lai, Huafang
 
<120>  Production of a Monoclonal Antibody Therapeutic Against West Nile
        Virus in Plants

<130>  02960-22805WO01

<150>  US 61/293,828
<151>  2010-01-11

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  650
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plant optimized new E16p Nucleic Acid sequence-HC variable region
       (EcoRI-intronless signal sequence-HC-HindIII)

<400>  1
gaattcacaa tgggatggtc ttgtatcatc cttttcttgg ttgcaacagc tactggtgtt       60

cattctcaag ttcaattggt gcagtcaggt gctgaggtga agaaaccagg tgcttcagtt      120

aaggtttctt gtaaggcttc tggttacaca ttcacagatt attggattga atgggtgaga      180

caagctcctg gtcagggtct tgagtggatg ggagatattc tttgtggaac tggaagaact      240

agatacaacg agaaacttaa ggctagagtt actatgactg ctgatacctc tacatctact      300

gcttacatgg aacttagatc tttgagatca gatgacactg ctgtgtacta ttgtgctagg      360

tcagcttctt atggagacta cgctgactat tggggacaag gtactactgt tactgtgtct      420

tctgcttcta ccaagggacc ttctgttttt ccacttgctc cttcttctaa gtctacttct      480

ggtggaactg ctgctttggg ttgtttggtg aaagattact ttcctgagcc agtgaccgtt      540

tcttggaact caggtgctct tacatctggt gttcatactt tcccagctgt tcttcaatct      600

tcaggacttt actcactttc ttctgttgtt accgttcctt cttcaagctt                 650


<210>  2
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plant optimized new E16p Amino Acid sequence-HC variable region 
       (EcoRI-intronless signal sequence-HC-HindIII)

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Cys Gly Thr Gly Arg Thr Arg Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ala Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Ser Tyr Gly Asp Tyr Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  3
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence of E16p Amino Acid sequence-heavy chain

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Cys Gly Thr Gly Arg Thr Arg Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ala Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Ser Tyr Gly Asp Tyr Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  4
<211>  1615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Total optimized heavy chain sequence (variable and constant 
       region together)

<400>  4
gaattcacaa tgggatggtc ttgtatcatc cttttcttgg ttgcaacagc tactggtgtt       60

cattctcaag ttcaattggt gcagtcaggt gctgaggtga agaaaccagg tgcttcagtt      120

aaggtttctt gtaaggcttc tggttacaca ttcacagatt attggattga atgggtgaga      180

caagctcctg gtcagggtct tgagtggatg ggagatattc tttgtggaac tggaagaact      240

agatacaacg agaaacttaa ggctagagtt actatgactg ctgatacctc tacatctact      300

gcttacatgg aacttagatc tttgagatca gatgacactg ctgtgtacta ttgtgctagg      360

tcagcttctt atggagacta cgctgactat tggggacaag gtactactgt tactgtgtct      420

tctgcttcta ccaagggacc ttctgttttt ccacttgctc cttcttctaa gtctacttct      480

ggtggaactg ctgctttggg ttgtttggtg aaagattact ttcctgagcc agtgaccgtt      540

tcttggaact caggtgctct tacatctggt gttcatactt tcccagctgt tcttcaatct      600

tcaggacttt actcactttc ttctgttgtt accgttcctt cttcaagctt gggcactcag      660

acctacatct gcaatgtgaa tcacaaaccc agcaacacca aggttgacaa gaaagttgag      720

cccaagtctt gtgacaagac tcatacgtgt ccaccgtgcc cagcacctga acttcttgga      780

ggaccgtcag tcttcttgtt tcctccaaag cctaaggata ccttgatgat ctccaggact      840

cctgaagtca catgtgtagt tgtggatgtg agccatgaag atcctgaggt gaagttcaac      900

tggtatgtgg atggtgtgga agtgcacaat gccaagacaa agccgagaga ggaacagtac      960

aacagcacgt acagggttgt ctcagttctc actgttctcc atcaagattg gttgaatggc     1020

aaagagtaca agtgcaaggt ctccaacaaa gccctcccag cccccattga gaagaccatt     1080

tccaaagcga aagggcaacc ccgtgaacca caagtgtaca cacttcctcc atctcgcgat     1140

gaactgacca agaaccaggt cagcttgact tgcctggtga aaggcttcta tccctctgac     1200

atagctgtag agtgggagag caatgggcaa ccggagaaca actacaagac tacacctccc     1260

gttctcgatt ctgacggctc cttcttcctc tacagcaagc tcacagtgga caagagcagg     1320

tggcaacaag ggaatgtctt ctcatgctcc gtgatgcatg aggctcttca caatcactac     1380

acacagaaga gtctctcctt gtctccgggt aaatgaggat cctctagagt cgacctgcag     1440

ggtctcagct tggtcgtatc actggaacaa caaccgctga ggctgttgtc actctaccac     1500

caccataact acgtctacat aaccgacgcc taccccagtt tcatagtatt ttctggtttg     1560

attgtatgaa taatataaat aaaaaaaaaa aaaaaaaaaa aaaactagtg agctc          1615


<210>  5
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of optimized heavy chain sequence

<400>  5

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Leu Cys Gly Thr Gly Arg Thr Arg Tyr Asn 
65                  70                  75                  80  


Glu Lys Leu Lys Ala Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Ala Ser Tyr Gly Asp Tyr Ala Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  6
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid for the optimized light chain sequence

<400>  6
atgggatggt cttgtatcat ccttttcttg gttgcaacag ctactggtgt tcattctgat       60

atcgttatga cacaatctcc agattctttg gctgtttctc ttggagagag ggctactatc      120

aattgcaagg cttctcaaga tgtttctact gctgttgctt ggtaccaaca gaaacctgga      180

cagccaccaa aacttcttat ctcttgggca tctactaggc acactggagt tccagataga      240

ttttctggat ctggatctgg aacagatttc actcttacta tctcatctct tcaagctgag      300

gatgttgcag tttattactg tcagcaacat tatacaactc cacttacttt cggacaagga      360

actaagttgg agatcaaaag aactgttgct gcaccatctg ttttcatctt ccctccatct      420

gatgagcagt tgaaatctgg aactgcttct gttgtgtgcc ttcttaataa cttctatcct      480

agagaggcta aagttcagtg gaaggtggat aacgcacttc aatctggtaa ctctcaagag      540

tctgttacag agcaagattc taaggactca acttactctc tttcatctac acttactttg      600

tcaaaagcag attacgagaa acacaaagtt tacgcatgcg aagttactca tcaaggactt      660

tcttcaccag ttacaaagtc tttcaataga ggagagtgtt aa                         702


<210>  7
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of optimized light chain sequence

<400>  7

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
    50                  55                  60                  


Leu Leu Ile Ser Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  8
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1 region of the heavy chain

<400>  8

Asn Glu Lys Leu Lys Ala Arg Val Thr Met Thr Ala Asp Thr Ser Thr 
1               5                   10                  15      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala 
            20                  25                  30          


Val Tyr Tyr Cys Ala Arg Ser Ala Ser Tyr Gly Asp Tyr Ala Asp Tyr 
        35                  40                  45              


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    50                  55                  60                  


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
65                  70                  75                  80  


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                85                  90                  95      


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            100                 105                 110         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        115                 120                 125             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    130                 135                 140                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
145                 150                 155     


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region of the heavy chain

<400>  9

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  10
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  annotates as the CH2 region

<400>  10

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3 region of the heavy chain

<400>  11

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


