
                                SEQUENCE LISTING

<110> Dix, Daniel 
      Walsh, Scott 
      Graham, Kenneth 
      Kamen, Douglas 

<120> Stabilized Formulations Containing Anti-Interleukin-6 Receptor (IL-6R) Antibodies
  

<130> 6013A

<140> To be assigned      
<141> 2011-01-07  

<150> US 61/293,227      
<151> 2010-01-08  

<160> 74

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 379
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 1
gaagtgcagc tggtggagtc tgggggaaac ttggtacagc ctggcaggtc cctgagactc 60
tcctgtgcag cctctggatt catctttgat gattatgcca tgcactgggt ccggcaagct 120
ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat 180
gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240
ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatgga 300
ggcagcagct ggttaccgtt cgtctactac tacggtatgg acgtctgggg ccaagggacc 360
acggtcaccg tctcgtcag                                              379

<210> 2
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Gly Gly Ser Ser Trp Leu Pro Phe Val Tyr Tyr Tyr Gly
            100                 105                 110         
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125     


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 3
ggattcatct ttgatgatta tgcc                                        24

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 4
Gly Phe Ile Phe Asp Asp Tyr Ala
 1               5              


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 5
attagttgga atagtggtag cata                                        24

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 6
Ile Ser Trp Asn Ser Gly Ser Ile
 1               5              


<210> 7
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 7
gcaaaagatg gaggcagcag ctggttaccg ttcgtctact actacggtat ggacgtc    57

<210> 8
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 8
Ala Lys Asp Gly Gly Ser Ser Trp Leu Pro Phe Val Tyr Tyr Tyr Gly
 1               5                  10                  15      
Met Asp Val
            


<210> 9
<211> 325
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 9
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctcccgggga aagagccacc 60
ctctcctgca gggccagtca gagtattagc agcaactttg cctggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct 240
gaagattttg cagtttatta ctgtcagcag tatagtagct ggcctccgta cacttttggc 300
caggggacca agctggagat caaac                                       325

<210> 10
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 10
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn
            20                  25                  30          
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Trp Pro Pro
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 11
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 11
cagagtatta gcagcaac                                               18

<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 12
Gln Ser Ile Ser Ser Asn
 1               5      


<210> 13
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 13
ggtgcatcc                                                         9

<210> 14
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 14
Gly Ala Ser
 1          


<210> 15
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 15
cagcagtata gtagctggcc tccgtacact                                  30

<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 16
Gln Gln Tyr Ser Ser Trp Pro Pro Tyr Thr
 1               5                  10  


<210> 17
<211> 349
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 17
gaagtgcagc tggtggagtc tgggggaggc ttggttcagc ctggcaggtc cctgagactc 60
tcctgtgcag cctctagatt tacctttgat gattatgcca tgcactgggt ccggcaagct 120
ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag aataggttat 180
gcggactctg tgaagggccg attcaccatc tccagagaca acgccgagaa ctccctcttt 240
ctgcaaatga acggtctgag agcagaggac acggccttgt attactgtgc aaaaggccga 300
gattcttttg atatctgggg ccaagggaca atggtcaccg tctcttcag             349

<210> 18
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 19
agatttacct ttgatgatta tgcc                                        24

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 20
Arg Phe Thr Phe Asp Asp Tyr Ala
 1               5              


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 21
attagttgga atagtggtag aata                                        24

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 22
Ile Ser Trp Asn Ser Gly Arg Ile
 1               5              


<210> 23
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 23
gcaaaaggcc gagattcttt tgatatc                                     27

<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 24
Ala Lys Gly Arg Asp Ser Phe Asp Ile
 1               5                  


<210> 25
<211> 322
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 25
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatggt gcatccagtt tggaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caagttatta ttgtcaacag gctaacagtt tcccgtacac ttttggccag 300
gggaccaagc tggagatcaa ac                                          322

<210> 26
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 27
cagggtatta gcagctgg                                               18

<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 28
Gln Gly Ile Ser Ser Trp
 1               5      


<210> 29
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 29
ggtgcatcc                                                         9

<210> 30
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 30
Gly Ala Ser
 1          


<210> 31
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 31
caacaggcta acagtttccc gtacact                                     27

<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 32
Gln Gln Ala Asn Ser Phe Pro Tyr Thr
 1               5                  


<210> 33
<211> 349
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 33
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttgat gattatgccc tgcactgggt ccggcaagct 120
ccagggaagg gcctggagtg ggtctcaggt gttagttgga atggtggtag aataggctat 180
gcggactctg tgaaaggccg attcaccatc tccagagaca acgccaagaa ctccctcttt 240
ctgcaaatga acagtctgag agttgaggac acggccttgt attattgtgc aaaaggccgg 300
gatgcttttg atatctgggg ccaagggaca ttggtcaccg tctcttcag             349

<210> 34
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
            20                  25                  30          
Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Gly Val Ser Trp Asn Gly Gly Arg Ile Gly Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gly Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 35
ggattcacct ttgatgatta tgcc                                        24

<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 36
Gly Phe Thr Phe Asp Asp Tyr Ala
 1               5              


<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 37
gttagttgga atggtggtag aata                                        24

<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 38
Val Ser Trp Asn Gly Gly Arg Ile
 1               5              


<210> 39
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 39
gcaaaaggcc gggatgcttt tgatatc                                     27

<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 40
Ala Lys Gly Arg Asp Ala Phe Asp Ile
 1               5                  


<210> 41
<211> 322
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 41
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca 120
gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttacta ttgtcaacat gcttacagtt tcccgtacac ttttggccag 300
gggaccaagc tggagatcaa ac                                          322

<210> 42
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ala Tyr Ser Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 43
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 43
cagggtatta gcagctgg                                               18

<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 44
Gln Gly Ile Ser Ser Trp
 1               5      


<210> 45
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 45
gctgcatcc                                                         9

<210> 46
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 46
Ala Ala Ser
 1          


<210> 47
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 47
caacatgctt acagtttccc gtacact                                     27

<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 48
Gln His Ala Tyr Ser Phe Pro Tyr Thr
 1               5                  


<210> 49
<211> 361
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 49
caggtgcagc tggtgcagtc tggggctgag gtgaaagagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc tcttatgata tcatctgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggatgg atgaacccaa acagtggtaa cacaggctat 180
acacagaacc tccagggcag agtcaccttg accaggaaca cctccataac tacagtctac 240
atggaactga gcagcctgag ctctgaggac acggccgttt attactgtgc gcgagactac 300
agtagccact actacggttt ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 360
a                                                                 361

<210> 50
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Asp Ile Ile Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Thr Gln Asn Leu
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Arg Asn Thr Ser Ile Thr Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Ser Ser His Tyr Tyr Gly Leu Asp Val Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser
        115                 120 


<210> 51
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 51
ggatacacct tcacctctta tgat                                        24

<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 52
Gly Tyr Thr Phe Thr Ser Tyr Asp
 1               5              


<210> 53
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 53
atgaacccaa acagtggtaa caca                                        24

<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 54
Met Asn Pro Asn Ser Gly Asn Thr
 1               5              


<210> 55
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 55
gcgcgagact acagtagcca ctactacggt ttggacgtc                        39

<210> 56
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 56
Ala Arg Asp Tyr Ser Ser His Tyr Tyr Gly Leu Asp Val
 1               5                  10              


<210> 57
<211> 322
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 57
gacatccagt tgacccagtc tccatccttc ctgtctacat ctataggaga cagagtcacc 60
atcacttgct gggccagtca ggacattagc aattatttag cctggtatca gcaaaaacca 120
gggaaagccc ctaagctcct gatctttgtt gcatccactt tgcagagtgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagtag cctgcagcct 240
gaggattttg caacttatta ctgtcaacag tttaatagtt acccgctcac tttcggcgga 300
gggaccaagg tggaaatcaa ac                                          322

<210> 58
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 58
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Thr Ser Ile Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Phe Val Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 59
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 59
caggacatta gcaattat                                               18

<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 60
Gln Asp Ile Ser Asn Tyr
 1               5      


<210> 61
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 61
gttgcatcc                                                         9

<210> 62
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 62
Val Ala Ser
 1          


<210> 63
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 63
caacagttta atagttaccc gctcactttc                                  30

<210> 64
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 64
Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe
 1               5                  10  


<210> 65
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220>
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Gly or Arg

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Phe or Tyr

<220>
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Ile or Thr

<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Phe

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Asp or Thr

<220>
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Asp or Ser

<220>
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Tyr

<220>
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Ala or Asp

<400> 65
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5              


<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic


<220>
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Ile, Val or Met

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ser or Asn

<220>
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Thr or Pro

<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Asn

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ser or Gly

<220>
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Gly

<220>
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Ser, Arg or Asn

<220>
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Ile or Thr

<400> 66
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5              


<210> 67
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220>
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Ala

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Lys or Arg

<220>
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Asp or Gly


<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Gly, Arg or Tyr

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Gly, Asp or Ser

<220>
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Ser or Ala

<220>
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Ser, Phe or His

<220>
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Trp, Asp or Tyr

<220>
<221> VARIANT        
<222> (9)...(9)
<223> Xaa = Leu, Ile or Tyr

<220>
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = Pro, Gly or absent

<220>
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Phe, Leu or absent

<220>
<221> VARIANT        
<222> (12)...(12)
<223> Xaa = Val, Asp or absent

<220>
<221> VARIANT        
<222> (13)...(13)
<223> Xaa = Tyr, Val or absent

<220>
<221> VARIANT        
<222> (14)...(14)
<223> Xaa = Tyr or absent

<220>
<221> VARIANT        
<222> (15)...(15)
<223> Xaa = Tyr or absent

<220>
<221> VARIANT        
<222> (16)...(16)
<223> Xaa = Gly or absent

<220>
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Met or absent

<220>
<221> VARIANT        
<222> (18)...(18)
<223> Xaa = Asp or absent

<220>
<221> VARIANT        
<222> (19)...(19)
<223> Xaa = Val or absent

<400> 67
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa
        


<210> 68
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220>
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Gln

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ser, Gly or Asp

<220>
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Ile

<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Ser

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ser or Asn

<220>
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Asn, Trp or Tyr

<400> 68
Xaa Xaa Xaa Xaa Xaa Xaa
 1               5      


<210> 69
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220>
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Gly, Ala or Val

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ala

<220>
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Ser

<400> 69
Xaa Xaa Xaa
 1          


<210> 70
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220>
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Gln

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Gln or His

<220>
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Tyr, Ala or Phe


<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Ser, Asn or Tyr

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ser

<220>
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Trp, Phe or Tyr

<220>
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Pro

<220>
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Pro, Tyr or Leu

<220>
<221> VARIANT        
<222> (9)...(9)
<223> Xaa = Tyr or Thr

<220>
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = Thr or absent

<400> 70
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10  


<210> 71
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 71
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 72
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 72
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 73
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 73
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 74
<211> 358
<212> PRT
<213> Homo sapiens

<400> 74
Met Val Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro
 1               5                  10                  15      
Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg
            20                  25                  30          
Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro
        35                  40                  45              
Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys
    50                  55                  60                  
Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg
65                  70                  75                  80  
Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys
                85                  90                  95      
Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val
            100                 105                 110         
Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser
        115                 120                 125             
Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr
    130                 135                 140                 
Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp
145                 150                 155                 160 
Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys
                165                 170                 175     
Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met
            180                 185                 190         
Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe
        195                 200                 205             
Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val
    210                 215                 220                 
Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp
225                 230                 235                 240 
Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg
                245                 250                 255     
Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp
            260                 265                 270         
Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His
        275                 280                 285             
Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser
    290                 295                 300                 
Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser
305                 310                 315                 320 
Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr
                325                 330                 335     
Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr
            340                 345                 350         
Ser Leu Pro Val Gln Asp
        355             

