                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  IMMUNE MODULATORS RELATED TO FOXO3A

<130>  706572

<150>  US 61/293,098
<151>  2010-01-07

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
agaauuugac aaggcacguc g                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
aaacacggua cuguugaagg a                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
auuuccuugg uugcccagag c                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
auagucugca ugggugacug a                                                 21


<210>  5
<211>  3183
<212>  DNA
<213>  Homo sapiens

<400>  5
actcgctccc tcccccggat cccgactggg aagggggcgg aggggacgac gtccgcgaga       60

atgcaaacca cacaaaaccc cgaagtggcc gtccccgccg ggctcgaacc tctgcgaaca      120

cccgctgggc tgctgctccc ccttctttct gtctttcctt tattttttgg aagtgacaag      180

ggcccatctg cgcccagacc cccgttcgcc ctctggcccg cgggcgaaga ggggagaggg      240

agctgcccgc gcagtccccg ggctcgggcc attcgaccgg gtggggggtg acggggggtc      300

gcggaggcgg ccaggctagg aaaggggaga agagccgaag acagcacaga cttgagcggc      360

ggcgccgcgg gaggcactag agcgggcccg agcgaaacat aaacaaacgc acgcacaccc      420

gagctcgggc tctgaccgcg gctcggctgc gccagctccg gccgctgccc gctttaaagg      480

cgcggccgcc cctcccccgg gcgcccctcc cccttctccc cgccccgccg cctagcccgg      540

gagggacctg cggctgggcg gcggggggag ggggctgccc cgcgcgaggc cgtcgattcg      600

ctcgcggctc catcgcggcc tggccggggg gcggtgtctg ctgcgccagg ttcgctggcc      660

gcacgtcttc aggtcctcct gttcctggga ggcgggcgcg gcaggactgg gaggtggcgg      720

cagcgggcga ggactcgccg aggacggggc tccggcccgg gataaccaac tctccttctc      780

tcttctttgg tgcttcccca ggcggcggcg gcggcgcccg ggagccggag ccttcgcggc      840

gtccacgtcc ctcccccgct gcaccccgcc ccggcgcgag aggagagcgc gagagcccca      900

gccgcgggcg ggcgggcggc gaagatggca gaggcaccgg cttccccggc cccgctctct      960

ccgctcgaag tggagctgga cccggagttc gagccccaga gccgtccgcg atcctgtacg     1020

tggcccctgc aaaggccgga gctccaagcg agccctgcca agccctcggg ggagacggcc     1080

gctgactcca tgatccccga ggaggaggac gatgaagacg acgaggacgg cgggggacgg     1140

gccggctcgg ccatggcgat cggcggcggc ggcgggagcg gcacgctggg ctccgggctg     1200

ctccttgagg actcggcccg ggtgctggca cccggagggc aagaccccgg gtctgggcca     1260

gccaccgcgg cgggcgggct gagcgggggt acacaggcgc tgctgcagcc tcagcaaccg     1320

ctgccaccgc cgcagccggg ggcggctggg ggctccgggc agccgaggaa atgttcgtcg     1380

cggcggaacg cctggggaaa cctgtcctac gcggacctga tcacccgcgc catcgagagc     1440

tccccggaca aacggctcac tctgtcccag atctacgagt ggatggtgcg ttgcgtgccc     1500

tacttcaagg ataagggcga cagcaacagc tctgccggct ggaagaactc catccggcac     1560

aacctgtcac tgcatagtcg attcatgcgg gtccagaatg agggaactgg caagagctct     1620

tggtggatca tcaaccctga tggggggaag agcggaaaag ccccccggcg gcgggctgtc     1680

tccatggaca atagcaacaa gtataccaag agccgtggcc gcgcagccaa gaagaaggca     1740

gccctgcaga cagcccccga atcagctgac gacagtccct cccagctctc caagtggcct     1800

ggcagcccca cgtcacgcag cagtgatgag ctggatgcgt ggacggactt ccgttcacgc     1860

accaattcta acgccagcac agtcagtggc cgcctgtcgc ccatcatggc aagcacagag     1920

ttggatgaag tccaggacga tgatgcgcct ctctcgccca tgctctacag cagctcagcc     1980

agcctgtcac cttcagtaag caagccgtgc acggtggaac tgccacggct gactgatatg     2040

gcaggcacca tgaatctgaa tgatgggctg actgaaaacc tcatggacga cctgctggat     2100

aacatcacgc tcccgccatc ccagccatcg cccactgggg gactcatgca gcggagctct     2160

agcttcccgt ataccaccaa gggctcgggc ctgggctccc caaccagctc ctttaacagc     2220

acggtgttcg gaccttcatc tctgaactcc ctacgccagt ctcccatgca gaccatccaa     2280

gagaacaagc cagctacctt ctcttccatg tcacactatg gtaaccagac actccaggac     2340

ctgctcactt cggactcact tagccacagc gatgtcatga tgacacagtc ggaccccttg     2400

atgtctcagg ccagcaccgc tgtgtctgcc cagaattccc gccggaacgt gatgcttcgc     2460

aatgatccga tgatgtcctt tgctgcccag cctaaccagg gaagtttggt caatcagaac     2520

ttgctccacc accagcacca aacccagggc gctcttggtg gcagccgtgc cttgtcgaat     2580

tctgtcagca acatgggctt gagtgagtcc agcagccttg ggtcagccaa acaccagcag     2640

cagtctcctg tcagccagtc tatgcaaacc ctctcggact ctctctcagg ctcctccttg     2700

tactcaacta gtgcaaacct gcccgtcatg ggccatgaga agttccccag cgacttggac     2760

ctggacatgt tcaatgggag cttggaatgt gacatggagt ccattatccg tagtgaactc     2820

atggatgctg atgggttgga ttttaacttt gattccctca tctccacaca gaatgttgtt     2880

ggtttgaacg tggggaactt cactggtgct aagcaggcct catctcagag ctgggtgcca     2940

ggctgaagga tcactgagga aggggaagtg ggcaaagcag accctcaaac tgacacaaga     3000

cctacagaga aaaccctttg ccaaatctgc tctcagcaag tggacagtga taccgtttac     3060

agcttaacac ctttgtgaat cccacgccat tttcctaacc cagcagagac tgttaatggc     3120

cccttaccct gggtgaagca cttacccttg gaacagaact ctaaaaagta tgcaaaatct     3180

tcc                                                                   3183


<210>  6
<211>  2889
<212>  DNA
<213>  Mus musculus

<400>  6
gctccctgtg agtggctata actttgtgct gctgccgcgg ccgccctgct cgtggaaggg       60

aggaggagga atgtggaagg cggcggcgca gcacaggctg acaggcggtt cctccggcgg      120

gctgcggcgg cggcccgaga gtcccctcgt cgcggtgccc tgggctcgcg cggaatcgta      180

cgccctcccg cctcgttcct gaagggaagg agccgagctg gagctcgaac cttcgcggtg      240

ccccgttcct cccccgccgc acccagcctg ggctcgagag gagagagcaa gagcccaagc      300

cgcgggcggc gggcaggcgg cgaagatggc agaggcacca gcctccccgg tcccgctctc      360

tccgctcgaa gtggagctgg acccagagtt cgagccacag agtcggccac gctcctgtac      420

gtggcccctg cagaggccgg agctgcaggc gagcccggcc aagccctcgg gggagacggc      480

cgcagactcc atgatccccg aggaggacga cgatgaagac gacgaggacg gcggcggccg      540

agccagctcg gccatggtga tcggtggcgg cgtgagcagc acgctgggtt ccgggctgct      600

cctcgaggat tcggccatgc tgctggctcc aggagggcag gacctcgggt cggggccagc      660

gtccgccgca ggcgctctga gtgggggcac gccgacgcag ctgcagcctc agcagccact      720

gccacagccg cagccggggg cggctggggg ctctgggcaa ccaaggaaat gctcctcgcg      780

gcggaatgcc tgggggaacc tgtcctatgc cgacctgatc acccgcgcca tcgagagctc      840

cccggacaaa cggctcactt tgtcccagat ctacgagtgg atggtgcgct gtgtgcccta      900

cttcaaggat aagggcgaca gcaacagctc tgcgggctgg aagaactcca tccggcacaa      960

cctgtccctg cacagccgct tcatgcgcgt tcagaatgaa ggcacgggca agagctcttg     1020

gtggatcatc aaccccgatg ggggaaagag cgggaaggcc ccccggcggc gtgcggtctc     1080

catggacaac agcaacaagt acaccaagag ccgaggccgg gcagccaaga agaaggcggc     1140

cctgcaggct gccccagagt cggcagacga cagtccttcc cagctctcca agtggcctgg     1200

cagccccacg tcccgcagca gcgacgagct ggatgcgtgg accgacttcc gctcgcgcac     1260

caattccaac gccagcaccg tgagcggccg cctgtcgccc atcctggcaa gcacggagct     1320

ggatgacgtc caggatgatg atggacccct gtcccccatg ctgtacagca gctctgccag     1380

cctgtcgccc tccgtgagca agccgtgtac tgtggagctt ccgcggctga cggacatggc     1440

cggcaccatg aatctgaatg atgggctggc cgagaacctc atggacgacc tgctggataa     1500

catcgcgctc ccgccatcgc agccatcgcc tcctggcggg cttatgcagc ggggctccag     1560

cttcccatat accgccaaga gctccggcct gggctcccca accggctcct tcaacagtac     1620

cgtgtttgga ccttcgtctc tgaactcctt gcgtcagtca cccatgcaga ctatccagga     1680

gaacagacca gccaccttct cttccgtgtc acactacggc aaccagacac tccaagacct     1740

gcttgcttca gactcactca gccacagcga cgtcatgatg acccagtcgg accccttgat     1800

gtctcaggct agcaccgccg tgtccgccca gaatgcccgc cggaacgtga tgcttcgcaa     1860

cgatccaatg atgtcctttg ctgcccagcc tacccagggg agtttggtca atcagaactt     1920

gctccaccac cagcaccaaa cccagggcgc tcttggtggc agccgtgcct tgtcaaattc     1980

tgtcagcaac atgggcttga gtgactccag cagccttggc tcagccaaac accagcagca     2040

gtctcccgcc agccagtcta tgcaaaccct ctcggactct ctctcaggct cctcactgta     2100

ttcagctagt gcaaaccttc ccgtcatggg ccacgataag ttccccagtg acttggacct     2160

ggacatgttc aatgggagct tggaatgtga catggagtcc atcatccgta gtgaactcat     2220

ggatgctgac gggttggatt ttaactttga ctccctcatc tccacacaga acgttgttgg     2280

tttgaatgtg gggaacttca ctggtgctaa gcaggcctca tctcaaagct gggtaccagg     2340

ctgaaggatc actgaggaaa ggggaaatgg gcaaagcaga ccctcaaact gacggaagac     2400

ctacagagaa aaccctttgc caaatctgct ctcagcaagt ggacagtgat ccgtttacag     2460

cttgacacct ttgagactcc cacgccgctt ccctaaccca gcagagactg ttagcagccc     2520

tggccctggg tgaagccctt acccgtggaa cagaactcta taacatatgc aaaatctaac     2580

tcatctgcaa gtgacctgcc agcgtggaca gcacccatca gcacccccca ctccttcaga     2640

gcacaccggg accccgttgg cgactccgtc gtgttttact atcatgatgg tttaggggat     2700

attttaagtg tcgtcttgtg tttgtttcct ttgaccctct gagttttcta cacacagtaa     2760

cctgcagtat ttttctgttg aaaatgttaa ctgtcctttc cctagcacac ttaaaagcag     2820

aaggaaggtg ttatatcagt tcccagtctg gccttgagca tcgcaagctt ttgagcctgt     2880

gggacccca                                                             2889


<210>  7
<211>  7341
<212>  DNA
<213>  Homo sapiens

<400>  7
gcgcgaggcc gtcgattcgc tcgcggctcc atcgcggcct ggccgggggg cggtgtctgc       60

tgcgccaggt tcgctggccg cacgtcttca ggtcctcctg ttcctgggag gcgggcgcgg      120

caggactggg aggtggcggc agcgggcgag gactcgccga ggacggggct ccggcccggg      180

ataaccaact ctccttctct cttctttggt gcttccccag gcggcggcgg cggcgcccgg      240

gagccggagc cttcgcggcg tccacgtccc tcccccgctg caccccgccc cggcgcgaga      300

ggagagcgcg agagccccag ccgcgggcgg gcgggcggcg aagatggcag aggcaccggc      360

ttccccggcc ccgctctctc cgctcgaagt ggagctggac ccggagttcg agccccagag      420

ccgtccgcga tcctgtacgt ggcccctgca aaggccggag ctccaagcga gccctgccaa      480

gccctcgggg gagacggccg ccgactccat gatccccgag gaggaggacg atgaagacga      540

cgaggacggc gggggacggg ccggctcggc catggcgatc ggcggcggcg gcgggagcgg      600

cacgctgggc tccgggctgc tccttgagga ctcggcccgg gtgctggcac ccggagggca      660

agaccccggg tctgggccag ccaccgcggc gggcgggctg agcgggggta cacaggcgct      720

gctgcagcct cagcaaccgc tgccaccgcc gcagccgggg gcggctgggg gctccgggca      780

gccgaggaaa tgttcgtcgc ggcggaacgc ctggggaaac ctgtcctacg cggacctgat      840

cacccgcgcc atcgagagct ccccggacaa acggctcact ctgtcccaga tctacgagtg      900

gatggtgcgt tgcgtgccct acttcaagga taagggcgac agcaacagct ctgccggctg      960

gaagaactcc atccggcaca acctgtcact gcatagtcga ttcatgcggg tccagaatga     1020

gggaactggc aagagctctt ggtggatcat caaccctgat ggggggaaga gcggaaaagc     1080

cccccggcgg cgggctgtct ccatggacaa tagcaacaag tataccaaga gccgtggccg     1140

cgcagccaag aagaaggcag ccctgcagac agcccccgaa tcagctgacg acagtccctc     1200

ccagctctcc aagtggcctg gcagccccac gtcacgcagc agtgatgagc tggatgcgtg     1260

gacggacttc cgttcacgca ccaattctaa cgccagcaca gtcagtggcc gcctgtcgcc     1320

catcatggca agcacagagt tggatgaagt ccaggacgat gatgcgcctc tctcgcccat     1380

gctctacagc agctcagcca gcctgtcacc ttcagtaagc aagccgtgca cggtggaact     1440

gccacggctg actgatatgg caggcaccat gaatctgaat gatgggctga ctgaaaacct     1500

catggacgac ctgctggata acatcacgct cccgccatcc cagccatcgc ccactggggg     1560

actcatgcag cggagctcta gcttcccgta taccaccaag ggctcgggcc tgggctcccc     1620

aaccagctcc tttaacagca cggtgttcgg accttcatct ctgaactccc tacgccagtc     1680

tcccatgcag accatccaag agaacaagcc agctaccttc tcttccatgt cacactatgg     1740

taaccagaca ctccaggacc tgctcacttc ggactcactt agccacagcg atgtcatgat     1800

gacacagtcg gaccccttga tgtctcaggc cagcaccgct gtgtctgccc agaattcccg     1860

ccggaacgtg atgcttcgca atgatccgat gatgtccttt gctgcccagc ctaaccaggg     1920

aagtttggtc aatcagaact tgctccacca ccagcaccaa acccagggcg ctcttggtgg     1980

cagccgtgcc ttgtcgaatt ctgtcagcaa catgggcttg agtgagtcca gcagccttgg     2040

gtcagccaaa caccagcagc agtctcctgt cagccagtct atgcaaaccc tctcggactc     2100

tctctcaggc tcctccttgt actcaactag tgcaaacctg cccgtcatgg gccatgagaa     2160

gttccccagc gacttggacc tggacatgtt caatgggagc ttggaatgtg acatggagtc     2220

cattatccgt agtgaactca tggatgctga tgggttggat tttaactttg attccctcat     2280

ctccacacag aatgttgttg gtttgaacgt ggggaacttc actggtgcta agcaggcctc     2340

atctcagagc tgggtgccag gctgaaggat cactgaggaa ggggaagtgg gcaaagcaga     2400

ccctcaaact gacacaagac ctacagagaa aaccctttgc caaatctgct ctcagcaagt     2460

ggacagtgat accgtttaca gcttaacacc tttgtgaatc ccacgccatt ttcctaaccc     2520

agcagagact gttaatggcc ccttaccctg ggtgaagcac ttacccttgg aacagaactc     2580

taaaaagtat gcaaaatctt ccttgtacag ggtggtgagc cgcctgccag tggaggacag     2640

cacccctcag caccacccac cctcattcag agcacaccgt gagcccccgt cggccattct     2700

gtggtgtttt aatattgcga tggtttatgg gacgttttaa gtgttgttct tgtgtttgtt     2760

ttcctttgac tttctgagtt tttcacatgc attaacttgc ggtatttttc tgttaaaatg     2820

ttaaccgtcc ttcccctagc aaatttaaaa acagaaagaa aatgttgtac cagttaccat     2880

tccgggttcg agcatcacaa gcttttgagc gcatggaact ccataaacta acaaattaca     2940

taaactaaag ggggattttc tttcttcttt tgtttggtag aaaattatcc ttttctaaaa     3000

actgaacaat ggcacaattg tttgctatgt gcacccgtcc aggacagaac cgtgcatagg     3060

caaaaggagt ggagcacagc gtccggccca gtgtgtttcc ggttctgagt cagggtgatc     3120

tgtggacggg accccagcac caagtctacg ggtgccagat cagtagggcc tgtgatttcc     3180

tgtcagtgtc ctcagctaat gtgaacagtg ttggtctgct ggttagaaac tagaatattg     3240

atattttcag gaaagaaatc agctcagctc tccactcatt gccaaatgtc actaaagggt     3300

ttagttttaa ggagaaagaa aaggaaaaaa aaaaaaaaca aaaaagtcct gttttgcttt     3360

gcagaacaaa tgaacttaca ggtgagcatt aagcttgcag tgagaaatgt gcgaagagta     3420

aaaacccaag tcaatgctga ggcagttcta acttcactgt tttcctaaat acacatcctt     3480

gattattttc agccttgcta tataatctga tctgctagaa gtgtatgagt gagaggcaat     3540

agcatacaaa ctgatttttt aaatataagc ttaggttgta attgtacaag tgactcaatg     3600

gaagtacaaa atagggcagt tttaactttt ttttctgctt ctatggattt cattttgttg     3660

tgttttcaaa aagttatggt gctgtatagg tgctttctgt ttaacctgga aagtgtgatt     3720

atattcgtta ccttctttgg tagacggaat agttgggacc acctttggta cataagaaat     3780

tggtataacg atgctctgat tagcacagta tatgcatact tctccaaagt gatatatgaa     3840

gactcttttc tttgcataaa aagcattagg catataaatg tataaatata ttttatcatg     3900

tacagtacaa aaatggaacc ttatgcatgg gccttaggaa tacaggctag tatttcagca     3960

cagacttccc tgcttgagtt cttgctgatg cttgcaccgt gacagtgggc accaacacag     4020

acgtgccacc caaccccctg cacacaccac cggccaccag gggccccctt gtgcgccttg     4080

gctttataac tcctctgggg gtgatattgg tggtgatcac agctcctagc ataatgagag     4140

ttccatttgg tattgtcaca cgtctcctgc ctcgcttggg ttgccatgtt tgagcgatgg     4200

ccctgttgat ttcaccctgc cttttactga atctgtaaat tgttgtgcaa ttgtggttat     4260

agtagactgt agcacattgc cttttctaaa ctgctacatg tttataatct tcatttttaa     4320

agtatgtgta atttttttaa gtatgtattc tattcatatg gtctgcttgt cagtgagcca     4380

gacttgctta ctatattcct ttataataat gctagccact tcctggattc tttagtaatg     4440

tgctgtatgc aagaactttc cagtagcagt gaaggagggt tgcctctcca agcttcctaa     4500

gggatgctgc cctgtgtggg gatgcattgc agaggcacta gtagcatggg ggctagagtg     4560

gggagcgaga tgtaaaaggg tggggggata ggagaattcc agagtgcttc cagcattagg     4620

gtcctgagaa cttctgagtt cagagaaaca tgcaaagtga ctaacaaaat agctacttac     4680

ctttgcagtt ttacagaccc tgggagctgc tttgggagtg agaaaggcaa ccctccaatg     4740

tgtttcaact ttaaaatgtt gaattctttt cagacatggt atctcattta ttctcctttt     4800

ctagcgtttg ttgaatttca ggcagaatgt cttacagaat gtcctagaac cagattatca     4860

tttaatctga aacagctgag gaagggacag agaaggtaca agggcaaggc agcacaaaac     4920

agatcaggag aatgaagagg gaatgctttg gttttttgtt ttgttttgtt ttttcttttt     4980

caagtaacta aaacagcatc tacatgtaga gtgttgtgga gagctgagac cagggtaaag     5040

tcaagtgcag catcagtact gcgagaccca ccagcccctg gagagggtca gccgagaatc     5100

tggtagtgaa gcctgtctag ggtcccggca ccctcaccct cagccacctg cagagaggcc     5160

agggccccag agactagcct ggttctgaag tgggcagggg tgctgccaga gccctctgcc     5220

ccttatgttg agaccctgct ttcaggacag gccagccgtt ggccaccatg tcacattctg     5280

agtgagtgtc acaggtccct aacaataatt ttctgatctg gagcatatca gcagaatgct     5340

tagcctcaag gggcctggca gctgtaatgt ttgatttatg atgagaacta tccgaggcca     5400

cccttggcct ctaaataagc tgctctaggg agccgcctac tttttgatga gaaattagaa     5460

gagtacctaa tgttgaaaac atgacatgcg ctcttgggat ctgctgttct ctccagggct     5520

ccagaacctg atacctgtta ccaaagctag gaaagagctt tatcacaagc cttcactgtc     5580

ctggcatgag aactggctgc caggctcagt gtaccccatt aactgtgaat gaatctgagc     5640

ttggtttcct ttattgcttc ctctgcaata tgattgctga aacacatttt aaaaattcag     5700

aagcttgtca ctcctgttaa tgggaggatc agtcacacat gtgtagtaca aggcggactt     5760

tgtgtttgtt tttggtgtta atttttagca ttgtgtgtgt tgcttcccca ccctgaggag     5820

aggacaccat ggcttactac tcaggacaag tatgccccgc tcagggtgtg atttcaggtg     5880

gcttccaaac ttgtacgcag tttaaagatg gtggggacag actttgcctc tacctagtga     5940

accccactta aagaataagg agcatttgaa tctcttggaa aaggccatga agaataaagc     6000

agtcaaaaag aagtcctcca tgttggtgcc aaggacttgc gaggggaaat aaaaatgtta     6060

tccagcctga ccaacatgga gaaaccccgt ctccattaaa aatacaaaat tagcctggca     6120

tggtggcgca tgcctgtaat cccagctact ctggaggctg aggcaggaga atcgcttgaa     6180

cccaggaggc ggaggtcgca gtgagccgag atcatgccag tgcactccag cctgggtaac     6240

aagagtgaaa ctccgtgtca aaaaaaaaaa aaaaatgtta ctcatcctct ctgaaagcaa     6300

aaaggaaacc ctaacagctc tgaactctgg ttttattttt cttgctgtat ttgggtgaac     6360

attgtatgat taggcataat gttaaaaaaa aaaatttttt tttggtagaa atgcaatcac     6420

cagtaaagag gtacgaaaaa gctagcctct ctcagagacc ggggaggcag agtactacta     6480

gaggaagtga agttctgatg gaatcatgcc tgtcaaatga ggtcttgaag cggatgccca     6540

aataaaagag tatattttat ctaaatctta agtgggtaac attttatgca gtttaaatga     6600

atggaatatt ttcctcttgt ttagttgtat ctgtttgtat ttttctttga tgaatgattg     6660

gtcatgaggc ctcttgccac actccagaaa tacgtgtgcg gctgctttta agaactatgt     6720

gtctggtcac ttatttctct aaaattatct cattgcctgg caatcagtct tctcttgtat     6780

acttgtccta gcacattatg tacatgggaa atgtaaacaa atgtgaagga ggaccagaaa     6840

aattagttaa tatttaaaaa aatgtattgt gcattttggc ttcacatgtt taactttttt     6900

taagaaaaaa gttgcatgaa tggaaaaaaa aatctgtata cagtatctgt aaaaactatc     6960

ttatctgttt caattccttg ctcatatccc atataatcta gaactaaata tggtgtgtgg     7020

ccatatttaa acacctgaga gtcaagcagt tgagactttg atttgaagca cctcatcctt     7080

ctttcaatgc gaacactatc atatggcatt cttactgagg attttgtcta accatatgtt     7140

gccatgaatt aactctgccg cctttcttaa ggatcaaaac cagtttgatt tgggaatctt     7200

cccctttcca aatgaaatag agatgcagta cttaactttc cttggtgttt gtagatattg     7260

ccttgtgtat tccacttaaa accgtaatct agtttgtaaa agagatggtg acgcatgtaa     7320

ataaagcatc agtgacactc t                                               7341


<210>  8
<211>  7314
<212>  DNA
<213>  Homo sapiens

<400>  8
ctgctcgtgg aagggaggag gaggaatgtg gaaggtggcg gcgcgcgagc tgacaggcgg       60

ttcctcgggc gggctgcggc gacggcccga gcgcttctcc ttcgccgagg ttgcgcgccc      120

cctcctcgcc gtgccccggg cccgcgcggg atcgtgcgtc gtcccgccgc gtccctgaag      180

ggaaggaagc gaggcggcgg cggcggcgcc cgggagccgg agccttcgcg gcgtccacgt      240

ccctcccccg ctgcaccccg ccccggcgcg agaggagagc gcgagagccc cagccgcggg      300

cgggcgggcg gcgaagatgg cagaggcacc ggcttccccg gccccgctct ctccgctcga      360

agtggagctg gacccggagt tcgagcccca gagccgtccg cgatcctgta cgtggcccct      420

gcaaaggccg gagctccaag cgagccctgc caagccctcg ggggagacgg ccgccgactc      480

catgatcccc gaggaggagg acgatgaaga cgacgaggac ggcgggggac gggccggctc      540

ggccatggcg atcggcggcg gcggcgggag cggcacgctg ggctccgggc tgctccttga      600

ggactcggcc cgggtgctgg cacccggagg gcaagacccc gggtctgggc cagccaccgc      660

ggcgggcggg ctgagcgggg gtacacaggc gctgctgcag cctcagcaac cgctgccacc      720

gccgcagccg ggggcggctg ggggctccgg gcagccgagg aaatgttcgt cgcggcggaa      780

cgcctgggga aacctgtcct acgcggacct gatcacccgc gccatcgaga gctccccgga      840

caaacggctc actctgtccc agatctacga gtggatggtg cgttgcgtgc cctacttcaa      900

ggataagggc gacagcaaca gctctgccgg ctggaagaac tccatccggc acaacctgtc      960

actgcatagt cgattcatgc gggtccagaa tgagggaact ggcaagagct cttggtggat     1020

catcaaccct gatgggggga agagcggaaa agccccccgg cggcgggctg tctccatgga     1080

caatagcaac aagtatacca agagccgtgg ccgcgcagcc aagaagaagg cagccctgca     1140

gacagccccc gaatcagctg acgacagtcc ctcccagctc tccaagtggc ctggcagccc     1200

cacgtcacgc agcagtgatg agctggatgc gtggacggac ttccgttcac gcaccaattc     1260

taacgccagc acagtcagtg gccgcctgtc gcccatcatg gcaagcacag agttggatga     1320

agtccaggac gatgatgcgc ctctctcgcc catgctctac agcagctcag ccagcctgtc     1380

accttcagta agcaagccgt gcacggtgga actgccacgg ctgactgata tggcaggcac     1440

catgaatctg aatgatgggc tgactgaaaa cctcatggac gacctgctgg ataacatcac     1500

gctcccgcca tcccagccat cgcccactgg gggactcatg cagcggagct ctagcttccc     1560

gtataccacc aagggctcgg gcctgggctc cccaaccagc tcctttaaca gcacggtgtt     1620

cggaccttca tctctgaact ccctacgcca gtctcccatg cagaccatcc aagagaacaa     1680

gccagctacc ttctcttcca tgtcacacta tggtaaccag acactccagg acctgctcac     1740

ttcggactca cttagccaca gcgatgtcat gatgacacag tcggacccct tgatgtctca     1800

ggccagcacc gctgtgtctg cccagaattc ccgccggaac gtgatgcttc gcaatgatcc     1860

gatgatgtcc tttgctgccc agcctaacca gggaagtttg gtcaatcaga acttgctcca     1920

ccaccagcac caaacccagg gcgctcttgg tggcagccgt gccttgtcga attctgtcag     1980

caacatgggc ttgagtgagt ccagcagcct tgggtcagcc aaacaccagc agcagtctcc     2040

tgtcagccag tctatgcaaa ccctctcgga ctctctctca ggctcctcct tgtactcaac     2100

tagtgcaaac ctgcccgtca tgggccatga gaagttcccc agcgacttgg acctggacat     2160

gttcaatggg agcttggaat gtgacatgga gtccattatc cgtagtgaac tcatggatgc     2220

tgatgggttg gattttaact ttgattccct catctccaca cagaatgttg ttggtttgaa     2280

cgtggggaac ttcactggtg ctaagcaggc ctcatctcag agctgggtgc caggctgaag     2340

gatcactgag gaaggggaag tgggcaaagc agaccctcaa actgacacaa gacctacaga     2400

gaaaaccctt tgccaaatct gctctcagca agtggacagt gataccgttt acagcttaac     2460

acctttgtga atcccacgcc attttcctaa cccagcagag actgttaatg gccccttacc     2520

ctgggtgaag cacttaccct tggaacagaa ctctaaaaag tatgcaaaat cttccttgta     2580

cagggtggtg agccgcctgc cagtggagga cagcacccct cagcaccacc caccctcatt     2640

cagagcacac cgtgagcccc cgtcggccat tctgtggtgt tttaatattg cgatggttta     2700

tgggacgttt taagtgttgt tcttgtgttt gttttccttt gactttctga gtttttcaca     2760

tgcattaact tgcggtattt ttctgttaaa atgttaaccg tccttcccct agcaaattta     2820

aaaacagaaa gaaaatgttg taccagttac cattccgggt tcgagcatca caagcttttg     2880

agcgcatgga actccataaa ctaacaaatt acataaacta aagggggatt ttctttcttc     2940

ttttgtttgg tagaaaatta tccttttcta aaaactgaac aatggcacaa ttgtttgcta     3000

tgtgcacccg tccaggacag aaccgtgcat aggcaaaagg agtggagcac agcgtccggc     3060

ccagtgtgtt tccggttctg agtcagggtg atctgtggac gggaccccag caccaagtct     3120

acgggtgcca gatcagtagg gcctgtgatt tcctgtcagt gtcctcagct aatgtgaaca     3180

gtgttggtct gctggttaga aactagaata ttgatatttt caggaaagaa atcagctcag     3240

ctctccactc attgccaaat gtcactaaag ggtttagttt taaggagaaa gaaaaggaaa     3300

aaaaaaaaaa acaaaaaagt cctgttttgc tttgcagaac aaatgaactt acaggtgagc     3360

attaagcttg cagtgagaaa tgtgcgaaga gtaaaaaccc aagtcaatgc tgaggcagtt     3420

ctaacttcac tgttttccta aatacacatc cttgattatt ttcagccttg ctatataatc     3480

tgatctgcta gaagtgtatg agtgagaggc aatagcatac aaactgattt tttaaatata     3540

agcttaggtt gtaattgtac aagtgactca atggaagtac aaaatagggc agttttaact     3600

tttttttctg cttctatgga tttcattttg ttgtgttttc aaaaagttat ggtgctgtat     3660

aggtgctttc tgtttaacct ggaaagtgtg attatattcg ttaccttctt tggtagacgg     3720

aatagttggg accacctttg gtacataaga aattggtata acgatgctct gattagcaca     3780

gtatatgcat acttctccaa agtgatatat gaagactctt ttctttgcat aaaaagcatt     3840

aggcatataa atgtataaat atattttatc atgtacagta caaaaatgga accttatgca     3900

tgggccttag gaatacaggc tagtatttca gcacagactt ccctgcttga gttcttgctg     3960

atgcttgcac cgtgacagtg ggcaccaaca cagacgtgcc acccaacccc ctgcacacac     4020

caccggccac caggggcccc cttgtgcgcc ttggctttat aactcctctg ggggtgatat     4080

tggtggtgat cacagctcct agcataatga gagttccatt tggtattgtc acacgtctcc     4140

tgcctcgctt gggttgccat gtttgagcga tggccctgtt gatttcaccc tgccttttac     4200

tgaatctgta aattgttgtg caattgtggt tatagtagac tgtagcacat tgccttttct     4260

aaactgctac atgtttataa tcttcatttt taaagtatgt gtaatttttt taagtatgta     4320

ttctattcat atggtctgct tgtcagtgag ccagacttgc ttactatatt cctttataat     4380

aatgctagcc acttcctgga ttctttagta atgtgctgta tgcaagaact ttccagtagc     4440

agtgaaggag ggttgcctct ccaagcttcc taagggatgc tgccctgtgt ggggatgcat     4500

tgcagaggca ctagtagcat gggggctaga gtggggagcg agatgtaaaa gggtgggggg     4560

ataggagaat tccagagtgc ttccagcatt agggtcctga gaacttctga gttcagagaa     4620

acatgcaaag tgactaacaa aatagctact tacctttgca gttttacaga ccctgggagc     4680

tgctttggga gtgagaaagg caaccctcca atgtgtttca actttaaaat gttgaattct     4740

tttcagacat ggtatctcat ttattctcct tttctagcgt ttgttgaatt tcaggcagaa     4800

tgtcttacag aatgtcctag aaccagatta tcatttaatc tgaaacagct gaggaaggga     4860

cagagaaggt acaagggcaa ggcagcacaa aacagatcag gagaatgaag agggaatgct     4920

ttggtttttt gttttgtttt gttttttctt tttcaagtaa ctaaaacagc atctacatgt     4980

agagtgttgt ggagagctga gaccagggta aagtcaagtg cagcatcagt actgcgagac     5040

ccaccagccc ctggagaggg tcagccgaga atctggtagt gaagcctgtc tagggtcccg     5100

gcaccctcac cctcagccac ctgcagagag gccagggccc cagagactag cctggttctg     5160

aagtgggcag gggtgctgcc agagccctct gccccttatg ttgagaccct gctttcagga     5220

caggccagcc gttggccacc atgtcacatt ctgagtgagt gtcacaggtc cctaacaata     5280

attttctgat ctggagcata tcagcagaat gcttagcctc aaggggcctg gcagctgtaa     5340

tgtttgattt atgatgagaa ctatccgagg ccacccttgg cctctaaata agctgctcta     5400

gggagccgcc tactttttga tgagaaatta gaagagtacc taatgttgaa aacatgacat     5460

gcgctcttgg gatctgctgt tctctccagg gctccagaac ctgatacctg ttaccaaagc     5520

taggaaagag ctttatcaca agccttcact gtcctggcat gagaactggc tgccaggctc     5580

agtgtacccc attaactgtg aatgaatctg agcttggttt cctttattgc ttcctctgca     5640

atatgattgc tgaaacacat tttaaaaatt cagaagcttg tcactcctgt taatgggagg     5700

atcagtcaca catgtgtagt acaaggcgga ctttgtgttt gtttttggtg ttaattttta     5760

gcattgtgtg tgttgcttcc ccaccctgag gagaggacac catggcttac tactcaggac     5820

aagtatgccc cgctcagggt gtgatttcag gtggcttcca aacttgtacg cagtttaaag     5880

atggtgggga cagactttgc ctctacctag tgaaccccac ttaaagaata aggagcattt     5940

gaatctcttg gaaaaggcca tgaagaataa agcagtcaaa aagaagtcct ccatgttggt     6000

gccaaggact tgcgagggga aataaaaatg ttatccagcc tgaccaacat ggagaaaccc     6060

cgtctccatt aaaaatacaa aattagcctg gcatggtggc gcatgcctgt aatcccagct     6120

actctggagg ctgaggcagg agaatcgctt gaacccagga ggcggaggtc gcagtgagcc     6180

gagatcatgc cagtgcactc cagcctgggt aacaagagtg aaactccgtg tcaaaaaaaa     6240

aaaaaaaatg ttactcatcc tctctgaaag caaaaaggaa accctaacag ctctgaactc     6300

tggttttatt tttcttgctg tatttgggtg aacattgtat gattaggcat aatgttaaaa     6360

aaaaaaattt ttttttggta gaaatgcaat caccagtaaa gaggtacgaa aaagctagcc     6420

tctctcagag accggggagg cagagtacta ctagaggaag tgaagttctg atggaatcat     6480

gcctgtcaaa tgaggtcttg aagcggatgc ccaaataaaa gagtatattt tatctaaatc     6540

ttaagtgggt aacattttat gcagtttaaa tgaatggaat attttcctct tgtttagttg     6600

tatctgtttg tatttttctt tgatgaatga ttggtcatga ggcctcttgc cacactccag     6660

aaatacgtgt gcggctgctt ttaagaacta tgtgtctggt cacttatttc tctaaaatta     6720

tctcattgcc tggcaatcag tcttctcttg tatacttgtc ctagcacatt atgtacatgg     6780

gaaatgtaaa caaatgtgaa ggaggaccag aaaaattagt taatatttaa aaaaatgtat     6840

tgtgcatttt ggcttcacat gtttaacttt ttttaagaaa aaagttgcat gaatggaaaa     6900

aaaaatctgt atacagtatc tgtaaaaact atcttatctg tttcaattcc ttgctcatat     6960

cccatataat ctagaactaa atatggtgtg tggccatatt taaacacctg agagtcaagc     7020

agttgagact ttgatttgaa gcacctcatc cttctttcaa tgcgaacact atcatatggc     7080

attcttactg aggattttgt ctaaccatat gttgccatga attaactctg ccgcctttct     7140

taaggatcaa aaccagtttg atttgggaat cttccccttt ccaaatgaaa tagagatgca     7200

gtacttaact ttccttggtg tttgtagata ttgccttgtg tattccactt aaaaccgtaa     7260

tctagtttgt aaaagagatg gtgacgcatg taaataaagc atcagtgaca ctct           7314


<210>  9
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Glu Ala Pro Ala Ser Pro Ala Pro Leu Ser Pro Leu Glu Val 
1               5                   10                  15      


Glu Leu Asp Pro Glu Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Gln Arg Pro Glu Leu Gln Ala Ser Pro Ala Lys Pro Ser 
        35                  40                  45              


Gly Glu Thr Ala Ala Asp Ser Met Ile Pro Glu Glu Glu Asp Asp Glu 
    50                  55                  60                  


Asp Asp Glu Asp Gly Gly Gly Arg Ala Gly Ser Ala Met Ala Ile Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Thr Leu Gly Ser Gly Leu Leu Leu Glu Asp 
                85                  90                  95      


Ser Ala Arg Val Leu Ala Pro Gly Gly Gln Asp Pro Gly Ser Gly Pro 
            100                 105                 110         


Ala Thr Ala Ala Gly Gly Leu Ser Gly Gly Thr Gln Ala Leu Leu Gln 
        115                 120                 125             


Pro Gln Gln Pro Leu Pro Pro Pro Gln Pro Gly Ala Ala Gly Gly Ser 
    130                 135                 140                 


Gly Gln Pro Arg Lys Cys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu 
145                 150                 155                 160 


Ser Tyr Ala Asp Leu Ile Thr Arg Ala Ile Glu Ser Ser Pro Asp Lys 
                165                 170                 175     


Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Arg Cys Val Pro 
            180                 185                 190         


Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn 
        195                 200                 205             


Ser Ile Arg His Asn Leu Ser Leu His Ser Arg Phe Met Arg Val Gln 
    210                 215                 220                 


Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Ile Ile Asn Pro Asp Gly 
225                 230                 235                 240 


Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn 
                245                 250                 255     


Ser Asn Lys Tyr Thr Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala 
            260                 265                 270         


Ala Leu Gln Thr Ala Pro Glu Ser Ala Asp Asp Ser Pro Ser Gln Leu 
        275                 280                 285             


Ser Lys Trp Pro Gly Ser Pro Thr Ser Arg Ser Ser Asp Glu Leu Asp 
    290                 295                 300                 


Ala Trp Thr Asp Phe Arg Ser Arg Thr Asn Ser Asn Ala Ser Thr Val 
305                 310                 315                 320 


Ser Gly Arg Leu Ser Pro Ile Met Ala Ser Thr Glu Leu Asp Glu Val 
                325                 330                 335     


Gln Asp Asp Asp Ala Pro Leu Ser Pro Met Leu Tyr Ser Ser Ser Ala 
            340                 345                 350         


Ser Leu Ser Pro Ser Val Ser Lys Pro Cys Thr Val Glu Leu Pro Arg 
        355                 360                 365             


Leu Thr Asp Met Ala Gly Thr Met Asn Leu Asn Asp Gly Leu Thr Glu 
    370                 375                 380                 


Asn Leu Met Asp Asp Leu Leu Asp Asn Ile Thr Leu Pro Pro Ser Gln 
385                 390                 395                 400 


Pro Ser Pro Thr Gly Gly Leu Met Gln Arg Ser Ser Ser Phe Pro Tyr 
                405                 410                 415     


Thr Thr Lys Gly Ser Gly Leu Gly Ser Pro Thr Ser Ser Phe Asn Ser 
            420                 425                 430         


Thr Val Phe Gly Pro Ser Ser Leu Asn Ser Leu Arg Gln Ser Pro Met 
        435                 440                 445             


Gln Thr Ile Gln Glu Asn Lys Pro Ala Thr Phe Ser Ser Met Ser His 
    450                 455                 460                 


Tyr Gly Asn Gln Thr Leu Gln Asp Leu Leu Thr Ser Asp Ser Leu Ser 
465                 470                 475                 480 


His Ser Asp Val Met Met Thr Gln Ser Asp Pro Leu Met Ser Gln Ala 
                485                 490                 495     


Ser Thr Ala Val Ser Ala Gln Asn Ser Arg Arg Asn Val Met Leu Arg 
            500                 505                 510         


Asn Asp Pro Met Met Ser Phe Ala Ala Gln Pro Asn Gln Gly Ser Leu 
        515                 520                 525             


Val Asn Gln Asn Leu Leu His His Gln His Gln Thr Gln Gly Ala Leu 
    530                 535                 540                 


Gly Gly Ser Arg Ala Leu Ser Asn Ser Val Ser Asn Met Gly Leu Ser 
545                 550                 555                 560 


Glu Ser Ser Ser Leu Gly Ser Ala Lys His Gln Gln Gln Ser Pro Val 
                565                 570                 575     


Ser Gln Ser Met Gln Thr Leu Ser Asp Ser Leu Ser Gly Ser Ser Leu 
            580                 585                 590         


Tyr Ser Thr Ser Ala Asn Leu Pro Val Met Gly His Glu Lys Phe Pro 
        595                 600                 605             


Ser Asp Leu Asp Leu Asp Met Phe Asn Gly Ser Leu Glu Cys Asp Met 
    610                 615                 620                 


Glu Ser Ile Ile Arg Ser Glu Leu Met Asp Ala Asp Gly Leu Asp Phe 
625                 630                 635                 640 


Asn Phe Asp Ser Leu Ile Ser Thr Gln Asn Val Val Gly Leu Asn Val 
                645                 650                 655     


Gly Asn Phe Thr Gly Ala Lys Gln Ala Ser Ser Gln Ser Trp Val Pro 
            660                 665                 670         


Gly 
    


<210>  10
<211>  2889
<212>  DNA
<213>  Mus musculus

<400>  10
gctccctgtg agtggctata actttgtgct gctgccgcgg ccgccctgct cgtggaaggg       60

aggaggagga atgtggaagg cggcggcgca gcacaggctg acaggcggtt cctccggcgg      120

gctgcggcgg cggcccgaga gtcccctcgt cgcggtgccc tgggctcgcg cggaatcgta      180

cgccctcccg cctcgttcct gaagggaagg agccgagctg gagctcgaac cttcgcggtg      240

ccccgttcct cccccgccgc acccagcctg ggctcgagag gagagagcaa gagcccaagc      300

cgcgggcggc gggcaggcgg cgaagatggc agaggcacca gcctccccgg tcccgctctc      360

tccgctcgaa gtggagctgg acccagagtt cgagccacag agtcggccac gctcctgtac      420

gtggcccctg cagaggccgg agctgcaggc gagcccggcc aagccctcgg gggagacggc      480

cgcagactcc atgatccccg aggaggacga cgatgaagac gacgaggacg gcggcggccg      540

agccagctcg gccatggtga tcggtggcgg cgtgagcagc acgctgggtt ccgggctgct      600

cctcgaggat tcggccatgc tgctggctcc aggagggcag gacctcgggt cggggccagc      660

gtccgccgca ggcgctctga gtgggggcac gccgacgcag ctgcagcctc agcagccact      720

gccacagccg cagccggggg cggctggggg ctctgggcaa ccaaggaaat gctcctcgcg      780

gcggaatgcc tgggggaacc tgtcctatgc cgacctgatc acccgcgcca tcgagagctc      840

cccggacaaa cggctcactt tgtcccagat ctacgagtgg atggtgcgct gtgtgcccta      900

cttcaaggat aagggcgaca gcaacagctc tgcgggctgg aagaactcca tccggcacaa      960

cctgtccctg cacagccgct tcatgcgcgt tcagaatgaa ggcacgggca agagctcttg     1020

gtggatcatc aaccccgatg ggggaaagag cgggaaggcc ccccggcggc gtgcggtctc     1080

catggacaac agcaacaagt acaccaagag ccgaggccgg gcagccaaga agaaggcggc     1140

cctgcaggct gccccagagt cggcagacga cagtccttcc cagctctcca agtggcctgg     1200

cagccccacg tcccgcagca gcgacgagct ggatgcgtgg accgacttcc gctcgcgcac     1260

caattccaac gccagcaccg tgagcggccg cctgtcgccc atcctggcaa gcacggagct     1320

ggatgacgtc caggatgatg atggacccct gtcccccatg ctgtacagca gctctgccag     1380

cctgtcgccc tccgtgagca agccgtgtac tgtggagctt ccgcggctga cggacatggc     1440

cggcaccatg aatctgaatg atgggctggc cgagaacctc atggacgacc tgctggataa     1500

catcgcgctc ccgccatcgc agccatcgcc tcctggcggg cttatgcagc ggggctccag     1560

cttcccatat accgccaaga gctccggcct gggctcccca accggctcct tcaacagtac     1620

cgtgtttgga ccttcgtctc tgaactcctt gcgtcagtca cccatgcaga ctatccagga     1680

gaacagacca gccaccttct cttccgtgtc acactacggc aaccagacac tccaagacct     1740

gcttgcttca gactcactca gccacagcga cgtcatgatg acccagtcgg accccttgat     1800

gtctcaggct agcaccgccg tgtccgccca gaatgcccgc cggaacgtga tgcttcgcaa     1860

cgatccaatg atgtcctttg ctgcccagcc tacccagggg agtttggtca atcagaactt     1920

gctccaccac cagcaccaaa cccagggcgc tcttggtggc agccgtgcct tgtcaaattc     1980

tgtcagcaac atgggcttga gtgactccag cagccttggc tcagccaaac accagcagca     2040

gtctcccgcc agccagtcta tgcaaaccct ctcggactct ctctcaggct cctcactgta     2100

ttcagctagt gcaaaccttc ccgtcatggg ccacgataag ttccccagtg acttggacct     2160

ggacatgttc aatgggagct tggaatgtga catggagtcc atcatccgta gtgaactcat     2220

ggatgctgac gggttggatt ttaactttga ctccctcatc tccacacaga acgttgttgg     2280

tttgaatgtg gggaacttca ctggtgctaa gcaggcctca tctcaaagct gggtaccagg     2340

ctgaaggatc actgaggaaa ggggaaatgg gcaaagcaga ccctcaaact gacggaagac     2400

ctacagagaa aaccctttgc caaatctgct ctcagcaagt ggacagtgat ccgtttacag     2460

cttgacacct ttgagactcc cacgccgctt ccctaaccca gcagagactg ttagcagccc     2520

tggccctggg tgaagccctt acccgtggaa cagaactcta taacatatgc aaaatctaac     2580

tcatctgcaa gtgacctgcc agcgtggaca gcacccatca gcacccccca ctccttcaga     2640

gcacaccggg accccgttgg cgactccgtc gtgttttact atcatgatgg tttaggggat     2700

attttaagtg tcgtcttgtg tttgtttcct ttgaccctct gagttttcta cacacagtaa     2760

cctgcagtat ttttctgttg aaaatgttaa ctgtcctttc cctagcacac ttaaaagcag     2820

aaggaaggtg ttatatcagt tcccagtctg gccttgagca tcgcaagctt ttgagcctgt     2880

gggacccca                                                             2889


<210>  11
<211>  672
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ala Glu Ala Pro Ala Ser Pro Val Pro Leu Ser Pro Leu Glu Val 
1               5                   10                  15      


Glu Leu Asp Pro Glu Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Gln Arg Pro Glu Leu Gln Ala Ser Pro Ala Lys Pro Ser 
        35                  40                  45              


Gly Glu Thr Ala Ala Asp Ser Met Ile Pro Glu Glu Asp Asp Asp Glu 
    50                  55                  60                  


Asp Asp Glu Asp Gly Gly Gly Arg Ala Ser Ser Ala Met Val Ile Gly 
65                  70                  75                  80  


Gly Gly Val Ser Ser Thr Leu Gly Ser Gly Leu Leu Leu Glu Asp Ser 
                85                  90                  95      


Ala Met Leu Leu Ala Pro Gly Gly Gln Asp Leu Gly Ser Gly Pro Ala 
            100                 105                 110         


Ser Ala Ala Gly Ala Leu Ser Gly Gly Thr Pro Thr Gln Leu Gln Pro 
        115                 120                 125             


Gln Gln Pro Leu Pro Gln Pro Gln Pro Gly Ala Ala Gly Gly Ser Gly 
    130                 135                 140                 


Gln Pro Arg Lys Cys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu Ser 
145                 150                 155                 160 


Tyr Ala Asp Leu Ile Thr Arg Ala Ile Glu Ser Ser Pro Asp Lys Arg 
                165                 170                 175     


Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Arg Cys Val Pro Tyr 
            180                 185                 190         


Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn Ser 
        195                 200                 205             


Ile Arg His Asn Leu Ser Leu His Ser Arg Phe Met Arg Val Gln Asn 
    210                 215                 220                 


Glu Gly Thr Gly Lys Ser Ser Trp Trp Ile Ile Asn Pro Asp Gly Gly 
225                 230                 235                 240 


Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn Ser 
                245                 250                 255     


Asn Lys Tyr Thr Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala Ala 
            260                 265                 270         


Leu Gln Ala Ala Pro Glu Ser Ala Asp Asp Ser Pro Ser Gln Leu Ser 
        275                 280                 285             


Lys Trp Pro Gly Ser Pro Thr Ser Arg Ser Ser Asp Glu Leu Asp Ala 
    290                 295                 300                 


Trp Thr Asp Phe Arg Ser Arg Thr Asn Ser Asn Ala Ser Thr Val Ser 
305                 310                 315                 320 


Gly Arg Leu Ser Pro Ile Leu Ala Ser Thr Glu Leu Asp Asp Val Gln 
                325                 330                 335     


Asp Asp Asp Gly Pro Leu Ser Pro Met Leu Tyr Ser Ser Ser Ala Ser 
            340                 345                 350         


Leu Ser Pro Ser Val Ser Lys Pro Cys Thr Val Glu Leu Pro Arg Leu 
        355                 360                 365             


Thr Asp Met Ala Gly Thr Met Asn Leu Asn Asp Gly Leu Ala Glu Asn 
    370                 375                 380                 


Leu Met Asp Asp Leu Leu Asp Asn Ile Ala Leu Pro Pro Ser Gln Pro 
385                 390                 395                 400 


Ser Pro Pro Gly Gly Leu Met Gln Arg Gly Ser Ser Phe Pro Tyr Thr 
                405                 410                 415     


Ala Lys Ser Ser Gly Leu Gly Ser Pro Thr Gly Ser Phe Asn Ser Thr 
            420                 425                 430         


Val Phe Gly Pro Ser Ser Leu Asn Ser Leu Arg Gln Ser Pro Met Gln 
        435                 440                 445             


Thr Ile Gln Glu Asn Arg Pro Ala Thr Phe Ser Ser Val Ser His Tyr 
    450                 455                 460                 


Gly Asn Gln Thr Leu Gln Asp Leu Leu Ala Ser Asp Ser Leu Ser His 
465                 470                 475                 480 


Ser Asp Val Met Met Thr Gln Ser Asp Pro Leu Met Ser Gln Ala Ser 
                485                 490                 495     


Thr Ala Val Ser Ala Gln Asn Ala Arg Arg Asn Val Met Leu Arg Asn 
            500                 505                 510         


Asp Pro Met Met Ser Phe Ala Ala Gln Pro Thr Gln Gly Ser Leu Val 
        515                 520                 525             


Asn Gln Asn Leu Leu His His Gln His Gln Thr Gln Gly Ala Leu Gly 
    530                 535                 540                 


Gly Ser Arg Ala Leu Ser Asn Ser Val Ser Asn Met Gly Leu Ser Asp 
545                 550                 555                 560 


Ser Ser Ser Leu Gly Ser Ala Lys His Gln Gln Gln Ser Pro Ala Ser 
                565                 570                 575     


Gln Ser Met Gln Thr Leu Ser Asp Ser Leu Ser Gly Ser Ser Leu Tyr 
            580                 585                 590         


Ser Ala Ser Ala Asn Leu Pro Val Met Gly His Asp Lys Phe Pro Ser 
        595                 600                 605             


Asp Leu Asp Leu Asp Met Phe Asn Gly Ser Leu Glu Cys Asp Met Glu 
    610                 615                 620                 


Ser Ile Ile Arg Ser Glu Leu Met Asp Ala Asp Gly Leu Asp Phe Asn 
625                 630                 635                 640 


Phe Asp Ser Leu Ile Ser Thr Gln Asn Val Val Gly Leu Asn Val Gly 
                645                 650                 655     


Asn Phe Thr Gly Ala Lys Gln Ala Ser Ser Gln Ser Trp Val Pro Gly 
            660                 665                 670         


<210>  12
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  12
agccgtgcct tgtcaaattc t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  13
tccttcaaca gtaccgtgtt t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  14
gctctgggca accaaggaaa t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  15
tcagtcaccc atgcagacta t                                                 21


<210>  16
<211>  1099
<212>  DNA
<213>  Homo sapiens

<400>  16
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg agaggggcca tggttggggg gatgcaggag      120

agggagccag ccctgactgt caagctgagg ctctttcccc cccaacccag caccccagcc      180

cagacaggga gctgggctct tttctgtctc tcccagcccc actccaagcc cataccccca      240

gcccctccat attgcaacag tcctcactcc cacaccaggt ccccgctccc tcccacttac      300

cccagaactt tctccccatt gcccagccag ctccctgctc ccagctgctt tactaaaggg      360

gaagttcctg ggcatctccg tgtttctctt tgtggggctc aaaacctcca aggacctctc      420

tcaatgccat tggttccttg gaccgtatca ctggtccacc tcctgagccc ctcaatccta      480

tcacagtcta ctgacttttc ccattcagct gtgagtgccc aaccctatcc cagagacctt      540

gatgcttggc ctcccaatct tgccctagga tacccagatg ccaaccagac acctccttct      600

tcctagccag gctatctggc ctgagacaac aaatgggtcc ctcagtctgg caatgggact      660

ctgagaactc ctcattccct gactcttagc cccagactct tcattcagtg gcccacattt      720

tccttaggaa aaacatgagc atccccagcc acaactgcca gctctctgat tccccaaatc      780

tgcatccttt tcaaaaccta aaaacaaaaa gaaaaacaaa taaaacaaaa ccaactcaga      840

ccagaactgt tttctcaacc tgggacttcc taaactttcc aaaaccttcc tcttccagca      900

actgaacctc gccataaggc acttatccct ggttcctagc accccttatc ccctcagaat      960

ccacaacttg taccaagttt cccttctccc agtccaagac cccaaatcac cacaaaggac     1020

ccaatcccca gactcaagat atggtctggg cgctgtcttg tgtctcctac cctgatccct     1080

gggttcaact ctgctccca                                                  1099


<210>  17
<211>  2653
<212>  DNA
<213>  Homo sapiens

<400>  17
ctcaaaaggg gccggatttc cttctcctgg aggcagatgt tgcctctctc tctcgctcgg       60

attggttcag tgcactctag aaacactgct gtggtggaga aactggaccc caggtctgga      120

gcgaattcca gcctgcaggg ctgataagcg aggcattagt gagattgaga gagactttac      180

cccgccgtgg tggttggagg gcgcgcagta gagcagcagc acaggcgcgg gtcccgggag      240

gccggctctg ctcgcgccga gatgtggaat ctccttcacg aaaccgactc ggctgtggcc      300

accgcgcgcc gcccgcgctg gctgtgcgct ggggcgctgg tgctggcggg tggcttcttt      360

ctcctcggct tcctcttcgg gtggtttata aaatcctcca atgaagctac taacattact      420

ccaaagcata atatgaaagc atttttggat gaattgaaag ctgagaacat caagaagttc      480

ttatataatt ttacacagat accacattta gcaggaacag aacaaaactt tcagcttgca      540

aagcaaattc aatcccagtg gaaagaattt ggcctggatt ctgttgagct agcacattat      600

gatgtcctgt tgtcctaccc aaataagact catcccaact acatctcaat aattaatgaa      660

gatggaaatg agattttcaa cacatcatta tttgaaccac ctcctccagg atatgaaaat      720

gtttcggata ttgtaccacc tttcagtgct ttctctcctc aaggaatgcc agagggcgat      780

ctagtgtatg ttaactatgc acgaactgaa gacttcttta aattggaacg ggacatgaaa      840

atcaattgct ctgggaaaat tgtaattgcc agatatggga aagttttcag aggaaataag      900

gttaaaaatg cccagctggc aggggccaaa ggagtcattc tctactccga ccctgctgac      960

tactttgctc ctggggtgaa gtcctatcca gatggttgga atcttcctgg aggtggtgtc     1020

cagcgtggaa atatcctaaa tctgaatggt gcaggagacc ctctcacacc aggttaccca     1080

gcaaatgaat atgcttatag gcgtggaatt gcagaggctg ttggtcttcc aagtattcct     1140

gttcatccaa ttggatacta tgatgcacag aagctcctag aaaaaatggg tggctcagca     1200

ccaccagata gcagctggag aggaagtctc aaagtgccct acaatgttgg acctggcttt     1260

actggaaact tttctacaca aaaagtcaag atgcacatcc actctaccaa tgaagtgaca     1320

agaatttaca atgtgatagg tactctcaga ggagcagtgg aaccagacag atatgtcatt     1380

ctgggaggtc accgggactc atgggtgttt ggtggtattg accctcagag tggagcagct     1440

gttgttcatg aaattgtgag gagctttgga acactgaaaa aggaagggtg gagacctaga     1500

agaacaattt tgtttgcaag ctgggatgca gaagaatttg gtcttcttgg ttctactgag     1560

tgggcagagg agaattcaag actccttcaa gagcgtggcg tggcttatat taatgctgac     1620

tcatctatag aaggaaacta cactctgaga gttgattgta caccgctgat gtacagcttg     1680

gtacacaacc taacaaaaga gctgaaaagc cctgatgaag gctttgaagg caaatctctt     1740

tatgaaagtt ggactaaaaa aagtccttcc ccagagttca gtggcatgcc caggataagc     1800

aaattgggat ctggaaatga ttttgaggtg ttcttccaac gacttggaat tgcttcaggc     1860

agagcacggt atactaaaaa ttgggaaaca aacaaattca gcggctatcc actgtatcac     1920

agtgtctatg aaacatatga gttggtggaa aagttttatg atccaatgtt taaatatcac     1980

ctcactgtgg cccaggttcg aggagggatg gtgtttgagc tagccaattc catagtgctc     2040

ccttttgatt gtcgagatta tgctgtagtt ttaagaaagt atgctgacaa aatctacagt     2100

atttctatga aacatccaca ggaaatgaag acatacagtg tatcatttga ttcacttttt     2160

tctgcagtaa agaattttac agaaattgct tccaagttca gtgagagact ccaggacttt     2220

gacaaaagca acccaatagt attaagaatg atgaatgatc aactcatgtt tctggaaaga     2280

gcatttattg atccattagg gttaccagac aggccttttt ataggcatgt catctatgct     2340

ccaagcagcc acaacaagta tgcaggggag tcattcccag gaatttatga tgctctgttt     2400

gatattgaaa gcaaagtgga cccttccaag gcctggggag aagtgaagag acagatttat     2460

gttgcagcct tcacagtgca ggcagctgca gagactttga gtgaagtagc ctaagaggat     2520

tctttagaga atccgtattg aatttgtgtg gtatgtcact cagaaagaat cgtaatgggt     2580

atattgataa attttaaaat tggtatattt gaaataaagt tgaatattat atataaaaaa     2640

aaaaaaaaaa aaa                                                        2653


<210>  18
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  18
atttgaggcc atataaagtc acctgaggcc ctctccacca cagcccacca gtgaccacga       60

aggctgtgct gcttgccctg ttgatggcag gcttggccct gcagccaggc actgccctgc      120

tgtgctactc ctgcaaagcc caggtgagca acgaggactg cctgcaggtg gagaactgca      180

cccagctggg ggagcagtgc tggaccgcgc gcatccgcgc agttggcctc ctgaccgtca      240

tcagcaaagg ctgcagcttg aactgcgtgg atgactcaca ggactactac gtgggcaaga      300

agaacatcac gtgctgtgac accgacttgt gcaacgccag cggggcccat gccctgcagc      360

cggctgctgc catccttgcg ctgctccctg cactcggcct gctgctctgg ggacccggcc      420

agctctaggc tctggggggc cccgctgcag cccacactgg gtgtggtgcc ccaggcctct      480

gtgccactcc tcacacaccc ggcccagtgg gagcctgtcc tggttcctga ggcacatcct      540

aacgcaagtc tgaccatgta tgtctgcgcc cctgtccccc accctgaccc tcccatggcc      600

ctctccagga ctcccacccg gcagatcggc tctattgaca cagatccgcc tgcagatggc      660

ccctccaacc ctctctgctg ctgtttccat ggcccagcat tctccaccct taaccctgtg      720

ctcaggcacc tcttccccca ggaagccttc cctgcccacc ccatctatga cttgagccag      780

gtctggtccg tggtgtcccc cgcacccagc aggggacagg cactcaggag ggcccggtaa      840

aggctgagat gaagtggact gagtagaact ggaggacagg agtcgacgtg agttcctggg      900

agtctccaga gatggggcct ggaggcctgg aggaaggggc caggcctcac attcgtgggg      960

ctccctgaat ggcagcctca gcacagcgta ggcccttaat aaacacctgt tggataagcc     1020

agaaaaaaaa aaaaaaaa                                                   1038


<210>  19
<211>  3163
<212>  DNA
<213>  Homo sapiens

<400>  19
tcaatccctt aattaaatag cttcccctct acaggctttt gaagtggtag cagttcctcc       60

taactcctgc cagaaacagc tctcctcaac atgagagctg cacccctcct cctggccagg      120

gcagcaagcc ttagccttgg cttcttgttt ctgctttttt tctggctaga ccgaagtgta      180

ctagccaagg agttgaagtt tgtgactttg gtgtttcggc atggagaccg aagtcccatt      240

gacacctttc ccactgaccc cataaaggaa tcctcatggc cacaaggatt tggccaactc      300

acccagctgg gcatggagca gcattatgaa cttggagagt atataagaaa gagatataga      360

aaattcttga atgagtccta taaacatgaa caggtttata ttcgaagcac agacgttgac      420

cggactttga tgagtgctat gacaaacctg gcagccctgt ttcccccaga aggtgtcagc      480

atctggaatc ctatcctact ctggcagccc atcccggtgc acacagttcc tctttctgaa      540

gatcagttgc tatacctgcc tttcaggaac tgccctcgtt ttcaagaact tgagagtgag      600

actttgaaat cagaggaatt ccagaagagg ctgcaccctt ataaggattt tatagctacc      660

ttgggaaaac tttcaggatt acatggccag gacctttttg gaatttggag taaagtctac      720

gaccctttat attgtgagag tgttcacaat ttcactttac cctcctgggc cactgaggac      780

accatgacta agttgagaga attgtcagaa ttgtccctcc tgtccctcta tggaattcac      840

aagcagaaag agaaatctag gctccaaggg ggtgtcctgg tcaatgaaat cctcaatcac      900

atgaagagag caactcagat accaagctac aaaaaactca tcatgtattc tgcgcatgac      960

actactgtga gtggcctaca gatggcgcta gatgtttaca acggactcct tcctccctat     1020

gcttcttgcc acttgacgga attgtacttt gagaaggggg agtactttgt ggagatgtac     1080

tatcggaatg agacgcagca cgagccgtat cccctcatgc tacctggctg cagccccagc     1140

tgtcctctgg agaggtttgc tgagctggtt ggccctgtga tccctcaaga ctggtccacg     1200

gagtgtatga ccacaaacag ccatcaaggt actgaagaca gtacagatta gtgtgcacag     1260

agatctctgt agaaggagta gctgcccttt ctcagggcag atgatgcttt gagaacatac     1320

tttggccatt acccccagct ttgaggaaaa tgggctttgg atgattattt tatgttttag     1380

ggacccccaa cctcaggcaa ttcctacctc ttcacctgac cctgccccca cttgccataa     1440

aacttagcta agttttgttt tgtttttcag cgttaatgta aaggggcagc agtgccaaaa     1500

tataatcaga gataaagctt aggtcaaagt tcatagagtt cccatgaact atatgactgg     1560

ccacacagga tcttttgtat ttaaggattc tgagattttg cttgagcagg attagataag     1620

gctgttcttt aaatgtctga aatggaacag atttcaaaaa aaaaccccac aatctaggat     1680

gggaacaagg aaggaaagat gtgaataggc tgatgggcaa aaaaccaatt tacccatcag     1740

ttccagcctt ctctcaagga gaggcaaaga aaggagatac agtggagaca tctggaaagt     1800

tttctccact ggaaaactgc tactatctgt ttttatattt ctgttaaaat atatgaggct     1860

acagaactaa aaattaaaac ctctttgtgt cccttggtcc tggaacattt atgttccttt     1920

taaagaaaca aaaatcaaac tttacagaaa gatttgatgt atgtaataca tatagcagct     1980

cttgaagtat atatatcata gcaaataagt catctgatga gaacaagcta tttgggcaca     2040

acacatcagg aaagagagca ccacgtgatg gagtttctct agaagctcca gtgataagag     2100

atgttgactc taaagttgat ttaaggccag gcatggtggt ttacgcctat aatcccagca     2160

ttttgggagt ccgaggtggg cagatcactt gagctcagga ggtcaagatc agcctgggca     2220

acatggtgaa acctggtctc tacataaaat acaaaaactt agatgggcat ggtggtgtgt     2280

gcctatagtc ccactacttg tggggctaag gcaggaggat cacttgagcc ccggaggtcg     2340

aggctacagt gagccaagag tgcactactg tactccagcc agggcaagag agcgagaccc     2400

tgtctcaata aataaataaa taaataaata aataaataaa taaataaata aaaacaaagt     2460

tgattaagaa aggaagtata ggccaggcac agtggctcac acctgtaatc cttgcatttt     2520

ggaaggctga ggcaggagga tcactttagg cctggtgtgt tcaagaccag cctggtcaac     2580

atagtgagac actgtctcta ccaaaaaaag gaaggaaggg acacatatca aactgaaaca     2640

aaattagaaa tgtaattatg ttctaagtgc ctccaagttc aaaacttatt ggaatgttga     2700

gagtgtggtt acgaaatacg ttaggaggac aaaaggaatg tgtaagtctt taatgccgat     2760

atcttcagaa aacctaagca aacttacagg tcctgctgaa actgcccact ctgcaagaag     2820

aaatcatgat atagctttgc catgtggcag atctacatgt ctagagaaca ctgtgctcta     2880

ttaccattat ggataaagat gagatggttt ctagagatgg tttctactgg ctgccagaat     2940

ctagagcaaa gccatccccg ctcctggttg gtcacagaat gactgacaaa gacatcgatt     3000

gatatgcttc tttgtgttat ttccctccca agtaaatgtt tgtccttggg tccattttct     3060

atgcttgtaa ctgtcttcta gcagtgagcc aaatgtaaaa tagtgaataa agtcattatt     3120

aggaagttca aaagcattgc ttttataatg aacttagaaa aac                       3163


<210>  20
<211>  4015
<212>  DNA
<213>  Homo sapiens

<400>  20
gcagcgctgc gtcctgctgc gcacgtggga agccctggcc ccggccaccc ccgcgatgcc       60

gcgcgctccc cgctgccgag ccgtgcgctc cctgctgcgc agccactacc gcgaggtgct      120

gccgctggcc acgttcgtgc ggcgcctggg gccccagggc tggcggctgg tgcagcgcgg      180

ggacccggcg gctttccgcg cgctggtggc ccagtgcctg gtgtgcgtgc cctgggacgc      240

acggccgccc cccgccgccc cctccttccg ccaggtgtcc tgcctgaagg agctggtggc      300

ccgagtgctg cagaggctgt gcgagcgcgg cgcgaagaac gtgctggcct tcggcttcgc      360

gctgctggac ggggcccgcg ggggcccccc cgaggccttc accaccagcg tgcgcagcta      420

cctgcccaac acggtgaccg acgcactgcg ggggagcggg gcgtgggggc tgctgctgcg      480

ccgcgtgggc gacgacgtgc tggttcacct gctggcacgc tgcgcgctct ttgtgctggt      540

ggctcccagc tgcgcctacc aggtgtgcgg gccgccgctg taccagctcg gcgctgccac      600

tcaggcccgg cccccgccac acgctagtgg accccgaagg cgtctgggat gcgaacgggc      660

ctggaaccat agcgtcaggg aggccggggt ccccctgggc ctgccagccc cgggtgcgag      720

gaggcgcggg ggcagtgcca gccgaagtct gccgttgccc aagaggccca ggcgtggcgc      780

tgcccctgag ccggagcgga cgcccgttgg gcaggggtcc tgggcccacc cgggcaggac      840

gcgtggaccg agtgaccgtg gtttctgtgt ggtgtcacct gccagacccg ccgaagaagc      900

cacctctttg gagggtgcgc tctctggcac gcgccactcc cacccatccg tgggccgcca      960

gcaccacgcg ggccccccat ccacatcgcg gccaccacgt ccctgggaca cgccttgtcc     1020

cccggtgtac gccgagacca agcacttcct ctactcctca ggcgacaagg agcagctgcg     1080

gccctccttc ctactcagct ctctgaggcc cagcctgact ggcgctcgga ggctcgtgga     1140

gaccatcttt ctgggttcca ggccctggat gccagggact ccccgcaggt tgccccgcct     1200

gccccagcgc tactggcaaa tgcggcccct gtttctggag ctgcttggga accacgcgca     1260

gtgcccctac ggggtgctcc tcaagacgca ctgcccgctg cgagctgcgg tcaccccagc     1320

agccggtgtc tgtgcccggg agaagcccca gggctctgtg gcggcccccg aggaggagga     1380

cacagacccc cgtcgcctgg tgcagctgct ccgccagcac agcagcccct ggcaggtgta     1440

cggcttcgtg cgggcctgcc tgcgccggct ggtgccccca ggcctctggg gctccaggca     1500

caacgaacgc cgcttcctca ggaacaccaa gaagttcatc tccctgggga agcatgccaa     1560

gctctcgctg caggagctga cgtggaagat gagcgtgcgg gactgcgctt ggctgcgcag     1620

gagcccaggg gttggctgtg ttccggccgc agagcaccgt ctgcgtgagg agatcctggc     1680

caagttcctg cactggctga tgagtgtgta cgtcgtcgag ctgctcaggt ctttctttta     1740

tgtcacggag accacgtttc aaaagaacag gctctttttc taccggaaga gtgtctggag     1800

caagttgcaa agcattggaa tcagacagca cttgaagagg gtgcagctgc gggagctgtc     1860

ggaagcagag gtcaggcagc atcgggaagc caggcccgcc ctgctgacgt ccagactccg     1920

cttcatcccc aagcctgacg ggctgcggcc gattgtgaac atggactacg tcgtgggagc     1980

cagaacgttc cgcagagaaa agagggccga gcgtctcacc tcgagggtga aggcactgtt     2040

cagcgtgctc aactacgagc gggcgcggcg ccccggcctc ctgggcgcct ctgtgctggg     2100

cctggacgat atccacaggg cctggcgcac cttcgtgctg cgtgtgcggg cccaggaccc     2160

gccgcctgag ctgtactttg tcaaggtgga tgtgacgggc gcgtacgaca ccatccccca     2220

ggacaggctc acggaggtca tcgccagcat catcaaaccc cagaacacgt actgcgtgcg     2280

tcggtatgcc gtggtccaga aggccgccca tgggcacgtc cgcaaggcct tcaagagcca     2340

cgtctctacc ttgacagacc tccagccgta catgcgacag ttcgtggctc acctgcagga     2400

gaccagcccg ctgagggatg ccgtcgtcat cgagcagagc tcctccctga atgaggccag     2460

cagtggcctc ttcgacgtct tcctacgctt catgtgccac cacgccgtgc gcatcagggg     2520

caagtcctac gtccagtgcc aggggatccc gcagggctcc atcctctcca cgctgctctg     2580

cagcctgtgc tacggcgaca tggagaacaa gctgtttgcg gggattcggc gggacgggct     2640

gctcctgcgt ttggtggatg atttcttgtt ggtgacacct cacctcaccc acgcgaaaac     2700

cttcctcagg accctggtcc gaggtgtccc tgagtatggc tgcgtggtga acttgcggaa     2760

gacagtggtg aacttccctg tagaagacga ggccctgggt ggcacggctt ttgttcagat     2820

gccggcccac ggcctattcc cctggtgcgg cctgctgctg gatacccgga ccctggaggt     2880

gcagagcgac tactccagct atgcccggac ctccatcaga gccagtctca ccttcaaccg     2940

cggcttcaag gctgggagga acatgcgtcg caaactcttt ggggtcttgc ggctgaagtg     3000

tcacagcctg tttctggatt tgcaggtgaa cagcctccag acggtgtgca ccaacatcta     3060

caagatcctc ctgctgcagg cgtacaggtt tcacgcatgt gtgctgcagc tcccatttca     3120

tcagcaagtt tggaagaacc ccacattttt cctgcgcgtc atctctgaca cggcctccct     3180

ctgctactcc atcctgaaag ccaagaacgc agggatgtcg ctgggggcca agggcgccgc     3240

cggccctctg ccctccgagg ccgtgcagtg gctgtgccac caagcattcc tgctcaagct     3300

gactcgacac cgtgtcacct acgtgccact cctggggtca ctcaggacag cccagacgca     3360

gctgagtcgg aagctcccgg ggacgacgct gactgccctg gaggccgcag ccaacccggc     3420

actgccctca gacttcaaga ccatcctgga ctgatggcca cccgcccaca gccaggccga     3480

gagcagacac cagcagccct gtcacgccgg gctctacgtc ccagggaggg aggggcggcc     3540

cacacccagg cccgcaccgc tgggagtctg aggcctgagt gagtgtttgg ccgaggcctg     3600

catgtccggc tgaaggctga gtgtccggct gaggcctgag cgagtgtcca gccaagggct     3660

gagtgtccag cacacctgcc gtcttcactt ccccacaggc tggcgctcgg ctccacccca     3720

gggccagctt ttcctcacca ggagcccggc ttccactccc cacataggaa tagtccatcc     3780

ccagattcgc cattgttcac ccctcgccct gccctccttt gccttccacc cccaccatcc     3840

aggtggagac cctgagaagg accctgggag ctctgggaat ttggagtgac caaaggtgtg     3900

ccctgtacac aggcgaggac cctgcacctg gatgggggtc cctgtgggtc aaattggggg     3960

gaggtgctgt gggagtaaaa tactgaatat atgagttttt cagttttgaa aaaaa          4015


<210>  21
<211>  2655
<212>  DNA
<213>  Homo sapiens

<400>  21
cccagaaggc cgcggggggt ggaccgccta agagggcgtg cgctcccgac atgccccgcg       60

gcgcgccatt aaccgccaga tttgaatcgc gggacccgtt ggcagaggtg gcggcggcgg      120

catgggtgcc ccgacgttgc cccctgcctg gcagcccttt ctcaaggacc accgcatctc      180

tacattcaag aactggccct tcttggaggg ctgcgcctgc accccggagc ggatggccga      240

ggctggcttc atccactgcc ccactgagaa cgagccagac ttggcccagt gtttcttctg      300

cttcaaggag ctggaaggct gggagccaga tgacgacccc atagaggaac ataaaaagca      360

ttcgtccggt tgcgctttcc tttctgtcaa gaagcagttt gaagaattaa cccttggtga      420

atttttgaaa ctggacagag aaagagccaa gaacaaaatt gcaaaggaaa ccaacaataa      480

gaagaaagaa tttgaggaaa ctgcggagaa agtgcgccgt gccatcgagc agctggctgc      540

catggattga ggcctctggc cggagctgcc tggtcccaga gtggctgcac cacttccagg      600

gtttattccc tggtgccacc agccttcctg tgggcccctt agcaatgtct taggaaagga      660

gatcaacatt ttcaaattag atgtttcaac tgtgctcttg ttttgtcttg aaagtggcac      720

cagaggtgct tctgcctgtg cagcgggtgc tgctggtaac agtggctgct tctctctctc      780

tctctctttt ttgggggctc atttttgctg ttttgattcc cgggcttacc aggtgagaag      840

tgagggagga agaaggcagt gtcccttttg ctagagctga cagctttgtt cgcgtgggca      900

gagccttcca cagtgaatgt gtctggacct catgttgttg aggctgtcac agtcctgagt      960

gtggacttgg caggtgcctg ttgaatctga gctgcaggtt ccttatctgt cacacctgtg     1020

cctcctcaga ggacagtttt tttgttgttg tgtttttttg tttttttttt tttggtagat     1080

gcatgacttg tgtgtgatga gagaatggag acagagtccc tggctcctct actgtttaac     1140

aacatggctt tcttattttg tttgaattgt taattcacag aatagcacaa actacaatta     1200

aaactaagca caaagccatt ctaagtcatt ggggaaacgg ggtgaacttc aggtggatga     1260

ggagacagaa tagagtgata ggaagcgtct ggcagatact ccttttgcca ctgctgtgtg     1320

attagacagg cccagtgagc cgcggggcac atgctggccg ctcctccctc agaaaaaggc     1380

agtggcctaa atccttttta aatgacttgg ctcgatgctg tgggggactg gctgggctgc     1440

tgcaggccgt gtgtctgtca gcccaacctt cacatctgtc acgttctcca cacgggggag     1500

agacgcagtc cgcccaggtc cccgctttct ttggaggcag cagctcccgc agggctgaag     1560

tctggcgtaa gatgatggat ttgattcgcc ctcctccctg tcatagagct gcagggtgga     1620

ttgttacagc ttcgctggaa acctctggag gtcatctcgg ctgttcctga gaaataaaaa     1680

gcctgtcatt tcaaacactg ctgtggaccc tactgggttt ttaaaatatt gtcagttttt     1740

catcgtcgtc cctagcctgc caacagccat ctgcccagac agccgcagtg aggatgagcg     1800

tcctggcaga gacgcagttg tctctgggcg cttgccagag ccacgaaccc cagacctgtt     1860

tgtatcatcc gggctccttc cgggcagaaa caactgaaaa tgcacttcag acccacttat     1920

ttctgccaca tctgagtcgg cctgagatag acttttccct ctaaactggg agaatatcac     1980

agtggttttt gttagcagaa aatgcactcc agcctctgta ctcatctaag ctgcttattt     2040

ttgatatttg tgtcagtctg taaatggata cttcacttta ataactgttg cttagtaatt     2100

ggctttgtag agaagctgga aaaaaatggt tttgtcttca actcctttgc atgccaggcg     2160

gtgatgtgga tctcggcttc tgtgagcctg tgctgtgggc agggctgagc tggagccgcc     2220

cctctcagcc cgcctgccac ggcctttcct taaaggccat ccttaaaacc agaccctcat     2280

ggctaccagc acctgaaagc ttcctcgaca tctgttaata aagccgtagg cccttgtcta     2340

agtgcaaccg cctagacttt ctttcagata catgtccaca tgtccatttt tcaggttctc     2400

taagttggag tggagtctgg gaagggttgt gaatgaggct tctgggctat gggtgaggtt     2460

ccaatggcag gttagagccc ctcgggccaa ctgccatcct ggaaagtaga gacagcagtg     2520

cccgctgccc agaagagacc agcaagccaa actggagccc ccattgcagg ctgtcgccat     2580

gtggaaagag taactcacaa ttgccaataa agtctcatgt ggttttatct aaaaaaaaaa     2640

aaaaaaaaaa aaaaa                                                      2655


<210>  22
<211>  1209
<212>  DNA
<213>  Homo sapiens

<400>  22
acctctcaag cagccagcgc ctgcctgaat ctgttctgcc ccctccccac ccatttcacc       60

accaccatga caccgggcac ccagtctcct ttcttcctgc tgctgctcct cacagtgctt      120

acagttgtta cgggttctgg tcatgcaagc tctaccccag gtggagaaaa ggagacttcg      180

gctacccaga gaagttcagt gcccagctct actgagaaga atgctttgtc tactggggtc      240

tctttctttt tcctgtcttt tcacatttca aacctccagt ttaattcctc tctggaagat      300

cccagcaccg actactacca agagctgcag agagacattt ctgaaatgtt tttgcagatt      360

tataaacaag ggggttttct gggcctctcc aatattaagt tcaggccagg atctgtggtg      420

gtacaattga ctctggcctt ccgagaaggt accatcaatg tccacgacgt ggagacacag      480

ttcaatcagt ataaaacgga agcagcctct cgatataacc tgacgatctc agacgtcagc      540

gtgagtgatg tgccatttcc tttctctgcc cagtctgggg ctggggtgcc aggctggggc      600

atcgcgctgc tggtgctggt ctgtgttctg gttgcgctgg ccattgtcta tctcattgcc      660

ttggctgtct gtcagtgccg ccgaaagaac tacgggcagc tggacatctt tccagcccgg      720

gatacctacc atcctatgag cgagtacccc acctaccaca cccatgggcg ctatgtgccc      780

cctagcagta ccgatcgtag cccctatgag aaggtttctg caggtaatgg tggcagcagc      840

ctctcttaca caaacccagc agtggcagcc acttctgcca acttgtaggg gcacgtcgcc      900

cgctgagctg agtggccagc cagtgccatt ccactccact caggttcttc agggccagag      960

cccctgcacc ctgtttgggc tggtgagctg ggagttcagg tgggctgctc acagcctcct     1020

tcagaggccc caccaatttc tcggacactt ctcagtgtgt ggaagctcat gtgggcccct     1080

gagggctcat gcctgggaag tgttgtggtg ggggctccca ggaggactgg cccagagagc     1140

cctgagatag cggggatcct gaactggact gaataaaacg tggtctccca ctgcgccaaa     1200

aaaaaaaaa                                                             1209


<210>  23
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Glu Arg Gly His Gly Trp Gly Asp Ala Gly Glu Gly Ala Ser Pro Asp 
            20                  25                  30          


Cys Gln Ala Glu Ala Leu Ser Pro Pro Thr Gln His Pro Ser Pro Asp 
        35                  40                  45              


Arg Glu Leu Gly Ser Phe Leu Ser Leu Pro Ala Pro Leu Gln Ala His 
    50                  55                  60                  


Thr Pro Ser Pro Ser Ile Leu Gln Gln Ser Ser Leu Pro His Gln Val 
65                  70                  75                  80  


Pro Ala Pro Ser His Leu Pro Gln Asn Phe Leu Pro Ile Ala Gln Pro 
                85                  90                  95      


Ala Pro Cys Ser Gln Leu Leu Tyr 
            100                 


<210>  24
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  25
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  26
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  27
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  28
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  29
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  30
<211>  2300
<212>  DNA
<213>  Homo sapiens

<400>  30
ggacaacacc ttcaaagaca ggccctctga gtccgacgag ctccagacca tccaagaaga       60

cagtgcagcc acctccgaga gcctggatgt gatggcgtca cagaagagac cctcccagag      120

gcacggatcc aagtacctgg ccacagcaag taccatggac catgccaggc atggcttcct      180

cccaaggcac agagacacgg gcatccttga ctccatcggg cgcttctttg gcggtgacag      240

gggtgcgccc aagcggggct ctggcaaggt accctggcta aagccgggcc ggagccctct      300

gccctctcat gcccgcagcc agcctgggct gtgcaacatg tacaaggact cacaccaccc      360

ggcaagaact gctcactacg gctccctgcc ccagaagtca cacggccgga cccaagatga      420

aaaccccgta gtccacttct tcaagaacat tgtgacgcct cgcacaccac ccccgtcgca      480

gggaaagggg agaggactgt ccctgagcag atttagctgg ggggccgaag gccagagacc      540

aggatttggc tacggaggca gagcgtccga ctataaatcg gctcacaagg gattcaaggg      600

agtcgatgcc cagggcacgc tttccaaaat ttttaagctg ggaggaagag atagtcgctc      660

tggatcaccc atggctagac gctgaaaacc cacctggttc cggaatcctg tcctcagctt      720

cttaatataa ctgccttaaa actttaatcc cacttgcccc tgttacctaa ttagagcaga      780

tgacccctcc cctaatgcct gcggagttgt gcacgtagta gggtcaggcc acggcagcct      840

accggcaatt tccggccaac agttaaatga gaacatgaaa acagaaaacg gttaaaactg      900

tccctttctg tgtgaagatc acgttccttc ccccgcaatg tgcccccaga cgcacgtggg      960

tcttcagggg gccaggtgca cagacgtccc tccacgttca cccctccacc cttggacttt     1020

cttttcgccg tggctgcggc acccttgcgc ttttgctggt cactgccatg gaggcacaca     1080

gctgcagaga cagagaggac gtgggcggca gagaggactg ttgacatcca agcttccttt     1140

gttttttttt cctgtccttc tctcacctcc taaagtagac ttcatttttc ctaacaggat     1200

tagacagtca aggagtggct tactacatgt gggagctttt ggtatgtgac atgcgggctg     1260

ggcagctgtt agagtccaac gtggggcagc acagagaggg ggccacctcc ccaggccgtg     1320

gctgcccaca caccccaatt agctgaattc gcgtgtggca gagggaggaa aaggaggcaa     1380

acgtgggctg ggcaatggcc tcacatagga aacagggtct tcctggagat ttggtgatgg     1440

agatgtcaag caggtggcct ctggacgtca ccgttgccct gcatggtggc cccagagcag     1500

cctctatgaa caacctcgtt tccaaaccac agcccacagc cggagagtcc aggaagactt     1560

gcgcactcag agcagaaggg taggagtcct ctagacagcc tcgcagccgc gccagtcgcc     1620

catagacact ggctgtgacc gggcgtgctg gcagcggcag tgcacagtgg ccagcactaa     1680

ccctccctga gaagataacc ggctcattca cttcctccca gaagacgcgt ggtagcgagt     1740

aggcacaggc gtgcacctgc tcccgaatta ctcaccgaga cacacgggct gagcagacgg     1800

ccccgtggat ggagacaaag agctcttctg accatatcct tcttaacacc cgctggcatc     1860

tcctttcgcg cctccctccc taacctactg acccaccttt tgattttagc gcacctgtga     1920

ttgataggcc ttccaaagag tcccacgctg gcatcaccct ccccgaggac ggagatgagg     1980

agtagtcagc gtgatgccaa aacgcgtctt cttaatccaa ttctaattct gaatgtttcg     2040

tgtgggctta ataccatgtc tattaatata tagcctcgat gatgagagag ttacaaagaa     2100

caaaactcca gacacaaacc tccaaatttt tcagcagaag cactctgcgt cgctgagctg     2160

aggtcggctc tgcgatccat acgtggccgc acccacacag cacgtgctgt gacgatggct     2220

gaacggaaag tgtacactgt tcctgaatat tgaaataaaa caataaactt ttaatggtaa     2280

aaaaaaaaaa aaaaaaaaaa                                                 2300


<210>  31
<211>  2777
<212>  DNA
<213>  Homo sapiens

<400>  31
gaattcggga aaagaccgaa gaaggaggct ggagagacca ggatccttcc agctgaacaa       60

agtcagccac aaagcagact agccagccgg ctacaattgg agtcagagtc ccaaagacat      120

gggcttgtta gagtgctgtg caagatgtct ggtaggggcc ccctttgctt ccctggtggc      180

cactggattg tgtttctttg gggtggcact gttctgtggc tgtggacatg aagccctcac      240

tggcacagaa aagctaattg agacctattt ctccaaaaac taccaagact atgagtatct      300

catcaatgtg atccatgcct tccagtatgt catctatgga actgcctctt tcttcttcct      360

ttatggggcc ctcctgctgg ctgagggctt ctacaccacc ggcgcagtca ggcagatctt      420

tggcgactac aagaccacca tctgcggcaa gggcctgagc gcaacggtaa cagggggcca      480

gaaggggagg ggttccagag gccaacatca agctcattct ttggagcggg tgtgtacttg      540

tttgggaaaa tggctaggac atcccgacaa gtttgtgggc atcacctatg ccctgaccgt      600

tgtgtggctc ctggtgtttg cctgctctgc tgtgcctgtg tacatttact tcaacacctg      660

gaccacctgc cagtctattg ccttccccag caagacctct gccagtatag gcagtctctg      720

tgctgacgcc agaatgtatg gtgttctccc atggaatgct ttccctggca aggtttgtgg      780

ctccaacctt ctgtccatct gcaaaacagc tgagttccaa atgaccttcc acctgtttat      840

tgctgcattt gtgggggctg cagctacact ggtttccctg ctcaccttca tgattgctgc      900

cacttacaac tttgccgtcc ttaaactcat gggccgaggc accaagttct gatcccccgt      960

agaaatcccc ctttctctaa tagcgaggct cctctaacca cacagcctac aatgctgcgt     1020

ctcccatctt aactctttgc ctttgccacc aactggccct cttcttactt gatgagtgta     1080

acaagaaagg agagtcttgc agtgattaag gtctctcttt ggactctccc ctcttatgta     1140

cctcttttag tcattttgct tcatagctgg ttcctgctag aaatgggaaa tgcctaagaa     1200

gatgacttcc caactcgaag tcacaaagga atggaggctc taattgaatt ttcaagcatc     1260

tcctgaggat cagaaagtaa tttcttctca aagggtactt ccactgatgg aaacaaagtg     1320

gaaggaaaga aggtcaggta cagagaagga atgtctttgg tcctcttgcc atctataggg     1380

gccaaatata ttctctttgg tgtacaaaat ggaattcatt ctggtctctc tattaccact     1440

gaagatagaa gaaaaaagaa tgtcagaaaa acaataagag cgtttgccca aatctgccta     1500

ttgcagctgg gagaaggggg tcaaagcaag gatctttcac ccacagaaag agagcactga     1560

ccccgatggc gatggactac tgaagcccta actcagccaa ccttacttac agcataaggg     1620

agcgtagaat ctgtgtagac gaagggggca tctggcctta cacctcgtta gggaagagaa     1680

acagggtgtt gtcagcatct tctcactccc ttctccttga taacagctac catgacaacc     1740

ctgtggtttc caaggagctg agaatagaag gaaactagct tacatgagaa cagactggcc     1800

tgaggagcag cagttcctgg tggctaatgg tgtaacctga gatggccctc tggtagacac     1860

aggatagata actctttgga tagcatgtct ttttttctgt taattagttg tgtactctgg     1920

cctctgtcat atcttcacaa tggtgctcat ttcatggggt attatccatt cagtcatcgt     1980

aggtgatttg aaggtcttga tttgttttag aatgatgcac atttcatgta ttccagtttg     2040

tttattactt atttggggtt gcatcagaaa tgtctggaga ataattcttt gattatgact     2100

gttttttaaa ctaggaaaat tggacattaa gcatcacaaa tgatattaaa aattggctag     2160

ttgaatctat tgggattttc tacaagtatt ctgcctttgc agaaacagat ttggtgaatt     2220

tgaatctcaa tttgagtaat ctgatcgttc tttctagcta atggaaaatg attttactta     2280

gcaatgttat cttggtgtgt taagagttag gtttaacata aaggttattt tctcctgata     2340

tagatcacat aacagaatgc accagtcatc agctattcag ttggtaagct tccaggaaaa     2400

aggacaggca gaaagagttt gagacctgaa tagctcccag atttcagtct tttcctgttt     2460

ttgttaactt tgggttaaaa aaaaaaaaag tctgattggt tttaattgaa ggaaagattt     2520

gtactacagt tcttttgttg taaagagttg tgttgttctt ttcccccaaa gtggtttcag     2580

caatatttaa ggagatgtaa gagctttaca aaaagacact tgatacttgt tttcaaacca     2640

gtatacaaga taagcttcca ggctgcatag aaggaggaga gggaaaatgt tttgtaagaa     2700

accaatcaag ataaaggaca gtgaagtaat ccgtaccttg tgttttgttt tgatttaata     2760

acataacaaa taaccaa                                                    2777


<210>  32
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  32
gtcatcccct cagtctgtag cccttttgtg tgagtgcctg gcaagggtga cgtggggctg       60

tttctgcggg cacagctgca gcaattaccg gagtggaggc agggcccagg cagcactgcc      120

ctccaagatc ttcccttggg cttttcagca gtaaggggac atgcacccca agggcctcca      180

cttggcctga ccttgctgcg ggggctctct gtccccagga acagtagaga tggcaagctt      240

atcaagaccc tctctgccca gctgcctctg ctccttcctc ctcctcctcc tcctccaagt      300

gtcttccagc tatgcagggc agttcagagt gataggacca agacacccta tccgggctct      360

ggtcggggat gaagtggaat tgccatgtcg catatctcct gggaagaacg ctacaggcat      420

ggaggtgggg tggtaccgcc cccccttctc tagggtggtt catctctaca gaaatggcaa      480

ggaccaagat ggagaccagg cacctgaata tcggggccgg acagagctgc tgaaagatgc      540

tattggtgag ggaaaggtga ctctcaggat ccggaatgta aggttctcag atgaaggagg      600

tttcacctgc ttcttccgag atcattctta ccaagaggag gcagcaatgg aattgaaagt      660

agaagatcct ttctactggg tgagccctgg agtgctggtt ctcctcgcgg tgctgcctgt      720

gctcctcctg cagatcactg ttggcctcat cttcctctgc ctgcagtaca gactgagagg      780

aaaacttcga gcagagatag agaatctcca ccggactttt gatccccact ttctgagggt      840

gccctgctgg aagataaccc tgtttgtaat tgtgccggtt cttggaccct tggttgcctt      900

gatcatctgc tacaactggc tacatcgaag actagcaggg caattccttg aagagctact      960

cttccacctg gaagccctct ctggctaagg acaggcaggt gcccctctct ccatcagagg     1020

acacctgtac tggagagcaa cacaggatgg tctctgccat gaactggagg ccaggaatct     1080

cctcactgaa aattacagta tggtaacttt gcaaatggtg gttgtttctt ccaagactcc     1140

agccctgatt gcgcaaaact gaaaggcatg tgaagggaag gaagaggaag agtgcaaaac     1200

attgaagaga gagctgagtg agctgaagag tgaggatatg agtagcccca acccaaacct     1260

ggagatgggg agaaacctac agaatactag ccagagctcc tccttgtctt ggcagcctac     1320

tagggacctg gggaagcaaa aacgaaagct gggcaacatg cctgctttag aatgttttcc     1380

ttctacttac acatcttcca caggtctcag aatctttcct tcctctcatc cttttctcct     1440

atcttcatat ctatcagagt atccactgtt tattcaacaa ctactacttg atggtcagac     1500

acaaacaaac aagctaggtg ctaattaata aagatacgag ttttggccgg gtgcggtggc     1560

tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcacga ggtcaggagt     1620

tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaacaattaa     1680

ctgagcatag tggtgggcac ctataatacc agctactccg gaggctgagg caggagaatc     1740

gcttgaaccc aggaggcaga ggttgcagtg agctgagatc gtgccactgc actctagccg     1800

gagtgacaga gtaagactct gtctcaaaaa taaataaata aataaataaa taaataaata     1860

aataaataaa taaaaaataa taatacaagt tttcataagc acacttctaa aaaaaaaaaa     1920


<210>  33
<211>  469
<212>  DNA
<213>  Homo sapiens

<400>  33
agccctccag gacaggctgc atcagaagag gccatcaagc agatcactgt ccttctgcca       60

tggccctgtg gatgcgcctc ctgcccctgc tggcgctgct ggccctctgg ggacctgacc      120

cagccgcagc ctttgtgaac caacacctgt gcggctcaca cctggtggaa gctctctacc      180

tagtgtgcgg ggaacgaggc ttcttctaca cacccaagac ccgccgggag gcagaggacc      240

tgcaggtggg gcaggtggag ctgggcgggg gccctggtgc aggcagcctg cagcccttgg      300

ccctggaggg gtccctgcag aagcgtggca ttgtggaaca atgctgtacc agcatctgct      360

ccctctacca gctggagaac tactgcaact agacgcagcc cgcaggcagc cccacacccg      420

ccgcctcctg caccgagaga gatggaataa agcccttgaa ccagcaaaa                  469


<210>  34
<211>  3488
<212>  DNA
<213>  Homo sapiens

<400>  34
gcaaaaccgt gagctggatt tataatcgcc ctataaagct ccagaggcgg tcaggcacct       60

gcagaggagc cccgccgctc cgccgactag ctgcccccgc gagcaacggc ctcgtgattt      120

ccccgccgat ccggtccccg cctccccact ctgcccccgc ctaccccgga gccgtgcagc      180

cgcctctccg aatctctctc ttctcctggc gctcgcgtgc gagagggaac tagcgagaac      240

gaggaagcag ctggaggtga cgccgggcag attacgcctg tcagggccga gccgagcgga      300

tcgctgggcg ctgtgcagag gaaaggcggg agtgcccggc tcgctgtcgc agagccgagc      360

ctgtttctgc gccggaccag tcgaggactc tggacagtag aggccccggg acgaccgagc      420

tgatggcgtc ttcgacccca tcttcgtccg caacctcctc gaacgcggga gcggacccca      480

ataccactaa cctgcgcccc acaacgtacg atacctggtg cggcgtggcc catggatgca      540

ccagaaaact ggggctcaag atctgcggct tcttgcaaag gaccaacagc ctggaagaga      600

agagtcgcct tgtgagtgcc ttcaaggaga ggcaatcctc caagaacctg ctttcctgtg      660

aaaacagcga ccgggatgcc cgcttccggc gcacagagac tgacttctct aatctgtttg      720

ctagagatct gcttccggct aagaacggtg aggagcaaac cgtgcaattc ctcctggaag      780

tggtggacat actcctcaac tatgtccgca agacatttga tcgctccacc aaggtgctgg      840

actttcatca cccacaccag ttgctggaag gcatggaggg cttcaacttg gagctctctg      900

accaccccga gtccctggag cagatcctgg ttgactgcag agacaccttg aagtatgggg      960

ttcgcacagg tcatcctcga tttttcaacc agctctccac tggattggat attattggcc     1020

tagctggaga atggctgaca tcaacggcca ataccaacat gtttacatat gaaattgcac     1080

cagtgtttgt cctcatggaa caaataacac ttaagaagat gagagagata gttggatggt     1140

caagtaaaga tggtgatggg atattttctc ctgggggcgc catatccaac atgtacagca     1200

tcatggctgc tcgctacaag tacttcccgg aagttaagac aaagggcatg gcggctgtgc     1260

ctaaactggt cctcttcacc tcagaacaga gtcactattc cataaagaaa gctggggctg     1320

cacttggctt tggaactgac aatgtgattt tgataaagtg caatgaaagg gggaaaataa     1380

ttccagctga ttttgaggca aaaattcttg aagccaaaca gaagggatat gttccctttt     1440

atgtcaatgc aactgctggc acgactgttt atggagcttt tgatccgata caagagattg     1500

cagatatatg tgagaaatat aacctttggt tgcatgtcga tgctgcctgg ggaggtgggc     1560

tgctcatgtc caggaagcac cgccataaac tcaacggcat agaaagggcc aactcagtca     1620

cctggaaccc tcacaagatg atgggcgtgc tgttgcagtg ctctgccatt ctcgtcaagg     1680

aaaagggtat actccaagga tgcaaccaga tgtgtgcagg atacctcttc cagccagaca     1740

agcagtatga tgtctcctac gacaccgggg acaaggcaat tcagtgtggc cgccacgtgg     1800

atatcttcaa gttctggctg atgtggaaag caaagggcac agtgggattt gaaaaccaga     1860

tcaacaaatg cctggaactg gctgaatacc tctatgccaa gattaaaaac agagaagaat     1920

ttgagatggt tttcaatggc gagcctgagc acacaaacgt ctgtttttgg tatattccac     1980

aaagcctcag gggtgtgcca gacagccctc aacgacggga aaagctacac aaggtggctc     2040

caaaaatcaa agccctgatg atggagtcag gtacgaccat ggttggctac cagccccaag     2100

gggacaaggc caacttcttc cggatggtca tctccaaccc agccgctacc cagtctgaca     2160

ttgacttcct cattgaggag atagaaagac tgggccagga tctgtaatca tccttcgcag     2220

aacatgagtt tatgggaatg ccttttccct ctggcactcc agaacaaacc tctatatgtt     2280

gctgaaacac acaggccatt tcattgaggg aaaacataat atcttgaaga atattgttaa     2340

aaccttactt aaagcttgtt tgttctagtt agcaggaaat agtgttcttt ttaaaaagtt     2400

gcacattagg aacagagtat atatgtacag ttatacatac ctctctctat atatacatgt     2460

atagtgagtg tggcttagta atagatcacg gcatgtttcc cgctccaaga gaattcactt     2520

taccttcagc agttaccgag gagctaaaca tgctgccaac cagcttgtcc aacaactcca     2580

ggaaaactgt ttttcaaaac gccatgtcct aggggccaag ggaaatgctg ttggtgagaa     2640

tcgacctcac tgtcagcgtt tctccacctg aagtgatgat ggatgagaaa aaacaccacc     2700

aaatgacaag tcacaccctc cccattagta tcctgttagg ggaaaatagt agcagagtca     2760

ttgttacagg tgtactatgg ctgtattttt agagattaat ttgtgtagat tgtgtaaatt     2820

cctgttgtct gaccttggtg gtgggagggg gagactatgt gtcatgattt caatgattgt     2880

ttaattgtag gtcaatgaaa tatttgctta tttatattca gagatgtacc atgttaaaga     2940

ggcgtcttgt attttcttcc catttgtaat gtatcttatt tatatatgaa gtaagttctg     3000

aaaactgttt atggtatttt cgtgcatttg tgagccaaag agaaaagatt aaaattagtg     3060

agatttgtat ttatattaga gtgcccttaa aataatgatt taagcatttt actgtctgta     3120

agagaattct aagattgtac ataaagtcat atatatggaa atcctgttac ttaaatagca     3180

tctgctcttc tcttacgctc tctgtctggc tgtacgtctg gtgttctcaa tgcttttcta     3240

gcaactgttg gataataact agatctcctg taattttgta gtagttgatg accaatctct     3300

gtgactcgct tagctgaaac ctaaggcaac atttccgaag accttctgaa gatctcagat     3360

aaagtgacca ggctcacaac tgtttttgaa gaagggaaat tcacactgtg cgttttagag     3420

tatgcaagaa gaatataaat aaataaaaat attctccatg gagaatttga acaaaaaaaa     3480

aaaaaaaa                                                              3488


<210>  35
<211>  5373
<212>  DNA
<213>  Homo sapiens

<400>  35
agcagttttt gtaggtgaaa acaatgaagc caggtaatat tgcaaggagg ctgtaatttt       60

agcagaccta ccaacaacac tgatgtagga agctcattat tttaatttct ggagcctttt      120

aattttttct ttagaaagtg tataaataat tgcagtgctg ctttgcttcc aaaactgggc      180

agtgagttca acaacaacga caacaacagc cgcagctcat cctggccgtc atggagtttc      240

ttgaaagaac gtatcttgtg aatgataaag ctgccaagat gtatgctttc acactagaaa      300

gtgtggaact ccaacagaaa ccggtgaata aagatcagtg tcccagagag agaccagagg      360

agctggagtc aggaggcatg taccactgcc acagtggctc caagcccaca gaaaaggggg      420

cgaatgagta cgcctatgcc aagtggaaac tctgttctgc ttcagcaata tgcttcattt      480

tcatgattgc agaggtcgtg ggtgggcaca ttgctgggag tcttgctgtt gtcacagatg      540

ctgcccacct cttaattgac ctgaccagtt tcctgctcag tctcttctcc ctgtggttgt      600

catcgaagcc tccctctaag cggctgacat ttggatggca ccgagcagag atccttggtg      660

ccctgctctc catcctgtgc atctgggtgg tgactggcgt gctagtgtac ctggcatgtg      720

agcgcctgct gtatcctgat taccagatcc aggcgactgt gatgatcatc gtttccagct      780

gcgcagtggc ggccaacatt gtactaactg tggttttgca ccagagatgc cttggccaca      840

atcacaagga agtacaagcc aatgccagcg tcagagctgc ttttgtgcat gcccttggag      900

atctatttca gagtatcagt gtgctaatta gtgcacttat tatctacttt aagccagagt      960

ataaaatagc cgacccaatc tgcacattca tcttttccat cctggtcttg gccagcacca     1020

tcactatctt aaaggacttc tccatcttac tcatggaagg tgtgccaaag agcctgaatt     1080

acagtggtgt gaaagagctt attttagcag tcgacggggt gctgtctgtg cacagcctgc     1140

acatctggtc tctaacaatg aatcaagtaa ttctctcagc tcatgttgct acagcagcca     1200

gccgggacag ccaagtggtt cggagagaaa ttgctaaagc ccttagcaaa agctttacga     1260

tgcactcact caccattcag atggaatctc cagttgacca ggaccccgac tgccttttct     1320

gtgaagaccc ctgtgactag ctcagtcaca ccgtcagttt cccaaatttg acaggccacc     1380

ttcaaacatg ctgctatgca gtttctgcat catagaaaat aaggaaccaa aggaagaaat     1440

tcatgtcatg gtgcaatgca cattttatct atttatttag ttccattcac catgaaggaa     1500

gaggcactga gatccatcaa tcaattggat tatatactga tcagtagctg tgttcaattg     1560

caggaatgtg tatatagatt attcctgagt ggagccgaag taacagctgt ttgtaactat     1620

cggcaatacc aaattcatct cccttccaat aatgcatctt gagaacacat aggtaaattt     1680

gaactcagga aagtcttact agaaatcagt ggaagggaca aatagtcaca aaattttacc     1740

aaaacattag aaacaaaaaa taaggagagc caagtcagga ataaaagtga ctctgtatgc     1800

taacgccaca ttagaacttg gttctctcac caagctgtaa tgtgattttt ttttctactc     1860

tgaattggaa atatgtatga atatacagag aagtgcttac aactaatttt tatttacttg     1920

tcacattttg gcaataaatc cctcttattt ctaaattcta acttgtttat ttcaaaactt     1980

tatataatca ctgttcaaaa ggaaatattt tcacctacca gagtgcttaa acactggcac     2040

cagccaaaga atgtggttgt agagacccag aagtcttcaa gaacagccga caaaaacatt     2100

cgagttgacc ccaccaagtt gttgccacag ataatttaga tatttacctg caagaaggaa     2160

taaagcagat gcaaccaatt cattcagtcc acgagcatga tgtgagcact gctttgtgct     2220

agacattggg cttagcattg aaactataaa gaggaatcag acgcagcaag tgcttctgtg     2280

ttctggtagc aactcaacac tatctgtgga gagtaaactg aagatgtgca ggccaacatt     2340

ctggaaatcc tatgtcaatg ggtttggttt ggaacctgga cttctgcatt tttaaaagtt     2400

acccagagat gcttctaaag atgagccata gtctagaaga ttgtcaacca caggagttca     2460

ttgagtggga cagctagaca catacattgg cagctacaat agtatcatga attgcaatga     2520

tgtagtgggg tataaaagga aagcgatgga tattgccgga tgggcatggc cagtgatgtt     2580

tcacgtcatt gaggtgacag ctctgctgga ctttgaatta catatggagg ctctccagga     2640

agacgaagaa gagaaggaca ttctaggcaa aaagaagact aggcacaagg cacacttatg     2700

tttgtctgtt agcttttagt tgaaaaagca aaatacatga tgcaaagaaa cctctccacg     2760

ctgtgatttt taaaactaca tactttttgc aactttatgg ttatgagtat tgtagagaac     2820

aggagatagg tcttagatga tttttatgtt gttgtcagac tctagcaagg tactagaaac     2880

ctagcaggca ttaataattg ttgaggcaat gactctgagg ctatatctgg gccttgtcat     2940

tatttatcat ttatatttgt atttttttct gaaatttgag ggccaagaaa acattgactt     3000

tgactgagga ggtcacatct gtgccatctc tgcaaatcaa tcagcaccac tgaaataact     3060

acttagcatt ctgctgagct ttccctgctc agtagagaca aatatactca tcccccacct     3120

cagtgagctt gtttaggcaa ccaggattag agctgctcag gttcccaacg tctcctgcca     3180

catcgggttc tcaaaatgga aagaatggtt tatgccaaat cacttttcct gtctgaagga     3240

ccactgaatg gttttgtttt tccatatttt gcataggacg ccctaaagac taggtgactt     3300

ggcaaacaca caagtgttag tataattctt tgcttctgct tctttttgaa aatcatgttt     3360

agatttgatt ttaagtcaga aattcactga atgtcaggta atcattatgg agggagattt     3420

gtgtgtcaac caaagtaatt gtcccatggc cccagggtat ttctgttgtt tccctgaaat     3480

tctgcttttt tagtcagcta gattgaaaac tctgaacagt agatgtttat atggcaaaat     3540

gcaagacaat ctacaaggga gattttaagg attttgagat gaaaaaacag atgctactca     3600

ggggctttat gaaccatcca tcaattctga agttctgact ctcccattac cctttccctg     3660

gtgtggtcag aactccaggt cactggaagt tagtggaatc atgtagttga attctttact     3720

tcaagacatt gtattctctc cagctatcaa aacattaatg atcttttatg tctttttttt     3780

gttattgtta tactttaagt tctggggtac atgtgcggaa catgtaggtt tgttacatag     3840

gtatacatgt gccatggtgg tttgctgcac tcatcaacct gtcatctaca ttcttttatg     3900

tctgtctttc aaagcaacac tctgttcttc tgagtagtga aatcaggtca actttaccac     3960

cagcctccat ttttaatatg cttcaccatc atccagcacc tacttaagat ttatctaggg     4020

ctctgtggtg atgttaggac ccataaaaga aatttatgcc ttccatatgt ttggttacag     4080

atgggaaatg ggaatgttga aggacatgaa agaaaggatg tttacacatt aagcatcagt     4140

tctgaagcta gattgtctga gtttgaatct tagctcttcc ctttattagc tctgtgacct     4200

cgagctagtt acttaaatgc tctgatcctc tatttcctga tcagtgaaac ctccctattc     4260

aaatgtgtga gagtttaata aattaggaca cttaaaaatg ttggagcagt gcatagcatg     4320

tagtgttcag tacatgttaa atgttgtttt ttattatgta caaacatgag tgggcacaga     4380

attttaaatc atctcaactt ttgagaaatt ttgagttatc aacaccgttc ccacaagaca     4440

gtggcaaaat tattggtgag aattaaacag ctgtttctca gaggaagcaa tggaggcttg     4500

ctgggataaa ggcatttact gagaggctgt tacctagtga gagtgatgaa ttaattaaaa     4560

tagtcgaatc cctttctgac tgtctctgaa agcttccgct tttatctttg aagagcagaa     4620

ttgtcactcc aaggacattt attaataaaa agaacaactg tccagtgcaa tgaaggcaaa     4680

gtcataggtc tcccaagtct taccccattc ctgtgaaata tcaagttctt ggcttttctc     4740

tgtcatgtag cctcaacttt ctctgaccgg gtgcatttct ttctctggtt tctaaattgc     4800

cagtggcaaa tttggatcac ttacttaata tctgttaaat tttgtgaccc aacaaagtct     4860

tttagcactg tggtgtcaaa aagaaaaaca cctcccaggc atatacattt tatagattcc     4920

tggagaatgt tgctctccag ctccatcccc acccaatgaa atatgatcca gagagtcttg     4980

caaagagaca agcctcattt tccacaatta gctctaaagt gcctccagga aatgattttc     5040

tcagctcatc tctctgtatt ccctgttttg gatcacaggg caatctgttt aaatgactaa     5100

ttacagaaat cattaaaggc accaagcaaa tgtcatctct gaatacacac atcccaagct     5160

ttacaaatcc tgcctggctt gacagtgatg aggccactta acagtccagc gcaggcggat     5220

gttaaaaaaa ataaaaaggt gaccatctgc ggtttagttt tttaactttc tgatttcaca     5280

cttaacgtct gtcattctgt tactgggcac ctgtttaaat tctattttaa aatgttaatg     5340

tgtgttgttt aaaataaaat caagaaagag aga                                  5373


<210>  36
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 
    130                 135                 140                 


Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 
145                 150                 155                 160 


Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
                165                 170                 175     


Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 
            180                 185                 190         


Pro Met Ala Arg Arg 
        195         


<210>  37
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys Thr Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  38
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 
                245                 250         


<210>  39
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  40
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 
1               5                   10                  15      


Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 
            20                  25                  30          


Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 
        35                  40                  45              


Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 
    50                  55                  60                  


Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 
65                  70                  75                  80  


Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 
                85                  90                  95      


Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 
            100                 105                 110         


Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 
        115                 120                 125             


Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 
    130                 135                 140                 


His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 
145                 150                 155                 160 


His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 
                165                 170                 175     


Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 
            180                 185                 190         


Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 
        195                 200                 205             


Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu 
    210                 215                 220                 


Met Glu Gln Ile Thr Leu Lys Lys Met Arg Glu Ile Val Gly Trp Ser 
225                 230                 235                 240 


Ser Lys Asp Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn 
                245                 250                 255     


Met Tyr Ser Ile Met Ala Ala Arg Tyr Lys Tyr Phe Pro Glu Val Lys 
            260                 265                 270         


Thr Lys Gly Met Ala Ala Val Pro Lys Leu Val Leu Phe Thr Ser Glu 
        275                 280                 285             


Gln Ser His Tyr Ser Ile Lys Lys Ala Gly Ala Ala Leu Gly Phe Gly 
    290                 295                 300                 


Thr Asp Asn Val Ile Leu Ile Lys Cys Asn Glu Arg Gly Lys Ile Ile 
305                 310                 315                 320 


Pro Ala Asp Phe Glu Ala Lys Ile Leu Glu Ala Lys Gln Lys Gly Tyr 
                325                 330                 335     


Val Pro Phe Tyr Val Asn Ala Thr Ala Gly Thr Thr Val Tyr Gly Ala 
            340                 345                 350         


Phe Asp Pro Ile Gln Glu Ile Ala Asp Ile Cys Glu Lys Tyr Asn Leu 
        355                 360                 365             


Trp Leu His Val Asp Ala Ala Trp Gly Gly Gly Leu Leu Met Ser Arg 
    370                 375                 380                 


Lys His Arg His Lys Leu Asn Gly Ile Glu Arg Ala Asn Ser Val Thr 
385                 390                 395                 400 


Trp Asn Pro His Lys Met Met Gly Val Leu Leu Gln Cys Ser Ala Ile 
                405                 410                 415     


Leu Val Lys Glu Lys Gly Ile Leu Gln Gly Cys Asn Gln Met Cys Ala 
            420                 425                 430         


Gly Tyr Leu Phe Gln Pro Asp Lys Gln Tyr Asp Val Ser Tyr Asp Thr 
        435                 440                 445             


Gly Asp Lys Ala Ile Gln Cys Gly Arg His Val Asp Ile Phe Lys Phe 
    450                 455                 460                 


Trp Leu Met Trp Lys Ala Lys Gly Thr Val Gly Phe Glu Asn Gln Ile 
465                 470                 475                 480 


Asn Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Ala Lys Ile Lys Asn 
                485                 490                 495     


Arg Glu Glu Phe Glu Met Val Phe Asn Gly Glu Pro Glu His Thr Asn 
            500                 505                 510         


Val Cys Phe Trp Tyr Ile Pro Gln Ser Leu Arg Gly Val Pro Asp Ser 
        515                 520                 525             


Pro Gln Arg Arg Glu Lys Leu His Lys Val Ala Pro Lys Ile Lys Ala 
    530                 535                 540                 


Leu Met Met Glu Ser Gly Thr Thr Met Val Gly Tyr Gln Pro Gln Gly 
545                 550                 555                 560 


Asp Lys Ala Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 
                565                 570                 575     


Gln Ser Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln 
            580                 585                 590         


Asp Leu 
        


<210>  41
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 
            20                  25                  30          


Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 
        35                  40                  45              


Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 
    50                  55                  60                  


Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly 
                85                  90                  95      


Ser Leu Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr 
            100                 105                 110         


Ser Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro 
        115                 120                 125             


Ser Lys Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Leu Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr 
                165                 170                 175     


Val Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu 
            180                 185                 190         


Thr Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val 
        195                 200                 205             


Gln Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp 
    210                 215                 220                 


Leu Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe 
225                 230                 235                 240 


Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser 
                245                 250                 255     


Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile 
            260                 265                 270         


Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys 
        275                 280                 285             


Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His 
    290                 295                 300                 


Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala 
305                 310                 315                 320 


Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys 
                325                 330                 335     


Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu 
            340                 345                 350         


Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys 
        355                 360                 365             


Asp 
    


<210>  42
<211>  9
<212>  PRT
<213>  Simian virus 40

<400>  42

Ser Glu Phe Leu Leu Glu Lys Arg Ile 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  43

Ser Val Tyr Asp Phe Phe Val Trp Leu 
1               5                   


<210>  44
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
auguugcuga cagaauucga c                                                 21


<210>  45
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
augaaucgac uaugcaguga c                                                 21


<210>  46
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
auguuaucca gcaggucguc c                                                 21


<210>  47
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
auagugugac auggaagaga a                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  48
gtcgaattct gtcagcaaca t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  49
gtcactgcat agtcgattca t                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  50
ggacgacctg ctggataaca t                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  51
ttctcttcca tgtcacacta t                                                 21


<210>  52
<211>  2143
<212>  DNA
<213>  Homo sapiens

<400>  52
agtgcctttg gttgctggag ggaagaacac aatggatctg gtgctaaaaa gatgccttct       60

tcatttggct gtgataggtg ctttgctggc tgtgggggct acaaaagtac ccagaaacca      120

ggactggctt ggtgtctcaa ggcaactcag aaccaaagcc tggaacaggc agctgtatcc      180

agagtggaca gaagcccaga gacttgactg ctggagaggt ggtcaagtgt ccctcaaggt      240

cagtaatgat gggcctacac tgattggtgc aaatgcctcc ttctctattg ccttgaactt      300

ccctggaagc caaaaggtat tgccagatgg gcaggttatc tgggtcaaca ataccatcat      360

caatgggagc caggtgtggg gaggacagcc agtgtatccc caggaaactg acgatgcctg      420

catcttccct gatggtggac cttgcccatc tggctcttgg tctcagaaga gaagctttgt      480

ttatgtctgg aagacctggg gccaatactg gcaagttcta gggggcccag tgtctgggct      540

gagcattggg acaggcaggg caatgctggg cacacacacc atggaagtga ctgtctacca      600

tcgccgggga tcccggagct atgtgcctct tgctcattcc agctcagcct tcaccattac      660

tgaccaggtg cctttctccg tgagcgtgtc ccagttgcgg gccttggatg gagggaacaa      720

gcacttcctg agaaatcagc ctctgacctt tgccctccag ctccatgacc ccagtggcta      780

tctggctgaa gctgacctct cctacacctg ggactttgga gacagtagtg gaaccctgat      840

ctctcgggca cttgtggtca ctcatactta cctggagcct ggcccagtca ctgcccaggt      900

ggtcctgcag gctgccattc ctctcacctc ctgtggctcc tccccagttc caggcaccac      960

agatgggcac aggccaactg cagaggcccc taacaccaca gctggccaag tgcctactac     1020

agaagttgtg ggtactacac ctggtcaggc gccaactgca gagccctctg gaaccacatc     1080

tgtgcaggtg ccaaccactg aagtcataag cactgcacct gtgcagatgc caactgcaga     1140

gagcacaggt atgacacctg agaaggtgcc agtttcagag gtcatgggta ccacactggc     1200

agagatgtca actccagagg ctacaggtat gacacctgca gaggtatcaa ttgtggtgct     1260

ttctggaacc acagctgcac aggtaacaac tacagagtgg gtggagacca cagctagaga     1320

gctacctatc cctgagcctg aaggtccaga tgccagctca atcatgtcta cggaaagtat     1380

tacaggttcc ctgggccccc tgctggatgg tacagccacc ttaaggctgg tgaagagaca     1440

agtccccctg gattgtgttc tgtatcgata tggttccttt tccgtcaccc tggacattgt     1500

ccagggtatt gaaagtgccg agatcctgca ggctgtgccg tccggtgagg gggatgcatt     1560

tgagctgact gtgtcctgcc aaggcgggct gcccaaggaa gcctgcatgg agatctcatc     1620

gccagggtgc cagccccctg cccagcggct gtgccagcct gtgctaccca gcccagcctg     1680

ccagctggtt ctgcaccaga tactgaaggg tggctcgggg acatactgcc tcaatgtgtc     1740

tctggctgat accaacagcc tggcagtggt cagcacccag cttatcatgc ctggtcaaga     1800

agcaggcctt gggcaggttc cgctgatcgt gggcatcttg ctggtgttga tggctgtggt     1860

ccttgcatct ctgatatata ggcgcagact tatgaagcaa gacttctccg taccccagtt     1920

gccacatagc agcagtcact ggctgcgtct accccgcatc ttctgctctt gtcccattgg     1980

tgagaatagc cccctcctca gtgggcagca ggtctgagta ctctcatatg atgctgtgat     2040

tttcctggag ttgacagaaa cacctatatt tcccccagtc ttccctggga gactactatt     2100

aactgaaata aatactcaga gcctgaaaaa aaaaaaaaaa aaa                       2143


<210>  53
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  54
<211>  1524
<212>  DNA
<213>  Homo sapiens

<400>  54
agcagacaga ggactctcat taaggaaggt gtcctgtgcc ctgaccctac aagatgccaa       60

gagaagatgc tcacttcatc tatggttacc ccaagaaggg gcacggccac tcttacacca      120

cggctgaaga ggccgctggg atcggcatcc tgacagtgat cctgggagtc ttactgctca      180

tcggctgttg gtattgtaga agacgaaatg gatacagagc cttgatggat aaaagtcttc      240

atgttggcac tcaatgtgcc ttaacaagaa gatgcccaca agaagggttt gatcatcggg      300

acagcaaagt gtctcttcaa gagaaaaact gtgaacctgt ggttcccaat gctccacctg      360

cttatgagaa actctctgca gaacagtcac caccacctta ttcaccttaa gagccagcga      420

gacacctgag acatgctgaa attatttctc tcacactttt gcttgaattt aatacagaca      480

tctaatgttc tcctttggaa tggtgtagga aaaatgcaag ccatctctaa taataagtca      540

gtgttaaaat tttagtaggt ccgctagcag tactaatcat gtgaggaaat gatgagaaat      600

attaaattgg gaaaactcca tcaataaatg ttgcaatgca tgatactatc tgtgccagag      660

gtaatgttag taaatccatg gtgttatttt ctgagagaca gaattcaagt gggtattctg      720

gggccatcca atttctcttt acttgaaatt tggctaataa caaactagtc aggttttcga      780

accttgaccg acatgaactg tacacagaat tgttccagta ctatggagtg ctcacaaagg      840

atacttttac aggttaagac aaagggttga ctggcctatt tatctgatca agaacatgtc      900

agcaatgtct ctttgtgctc taaaattcta ttatactaca ataatatatt gtaaagatcc      960

tatagctctt tttttttgag atggagtttc gcttttgttg cccaggctgg agtgcaatgg     1020

cgcgatcttg gctcaccata acctccgcct cccaggttca agcaattctc ctgccttagc     1080

ctcctgagta gctgggatta caggcgtgcg ccactatgcc tgactaattt tgtagtttta     1140

gtagagacgg ggtttctcca tgttggtcag gctggtctca aactcctgac ctcaggtgat     1200

ctgcccgcct cagcctccca aagtgctgga attacaggcg tgagccacca cgcctggctg     1260

gatcctatat cttaggtaag acatataacg cagtctaatt acatttcact tcaaggctca     1320

atgctattct aactaatgac aagtattttc tactaaacca gaaattggta gaaggattta     1380

aataagtaaa agctactatg tactgcctta gtgctgatgc ctgtgtactg ccttaaatgt     1440

acctatggca atttagctct cttgggttcc caaatccctc tcacaagaat gtgcagaaga     1500

aatcataaag gatcagagat tctg                                            1524


<210>  55
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  56
<211>  3878
<212>  DNA
<213>  Homo sapiens

<400>  56
ggctccccac tctgccagag cgaggcgggg cagtgaggac tccgcgacgc gtccgcaccc       60

tgcggccaga gcggctttga gctcggctgc gtccgcgcta ggcgcttttt cccagaagca      120

atccaggcgc gcccgctggt tcttgagcgc caggaaaagc ccggagctaa cgaccggccg      180

ctcggccact gcacggggcc ccaagccgca gaaggacgac gggagggtaa tgaagctgag      240

cccaggtctc ctaggaagga gagagtgcgc cggagcagcg tgggaaagaa gggaagagtg      300

tcgttaagtt tacggccaac ggtggattat ccgggccgct gcgcgtctgg gggctgcgga      360

atgcgcgagg agaacaaggg catgcccagt gggggcggca gcgatgaggg tctggccagc      420

gccgcggcgc ggggactagt ggagaaggtg cgacagctcc tggaagccgg cgcggatccc      480

aacggagtca accgtttcgg gaggcgcgcg atccaggtca tgatgatggg cagcgcccgc      540

gtggcggagc tgctgctgct ccacggcgcg gagcccaact gcgcagaccc tgccactctc      600

acccgaccgg tgcatgatgc tgcccgggag ggcttcctgg acacgctggt ggtgctgcac      660

cgggccgggg cgcggctgga cgtgcgcgat gcctggggtc gtctgcccgt ggacttggcc      720

gaggagcggg gccaccgcga cgttgcaggg tacctgcgca cagccacggg ggactgacgc      780

caggttcccc agccgcccac aacgacttta ttttcttacc caatttccca cccccaccca      840

cctaattcga tgaaggctgc caacggggag cggcggaaag cctgtaagcc tgcaagcctg      900

tctgagactc acaggaagga ggagccgacc gggaataacc ttccatacat ttttttcttt      960

gtcttatctg gccctcgaca ctcaccatga agcgaaacac agagaagcgg atttccaggg     1020

atatttagga gtgtgtgaca ttccaggggt cgtttgcttt tcagggtttt ctgagggaaa     1080

gtgcatatga aatccttgac tggacctggt ggctacgaat cttccgatgg atgaatctcc     1140

cactccagcg ctgagtggga gaaggcagtg attagcactt gggtgacggc agtcgatgcg     1200

ttcactccaa tgtctgctga ggagttatgg tgaacccaca acttaggccc tagcggcaga     1260

aaggaaaacc tgaagactga ggacaaagtg gaggagggcc gaggtgggct tcagtaagtc     1320

cccggcggcg ctttagtttg agcgcatggc aagtcacatg cgtaaacgac actctctgga     1380

agccctggag accctcgccc aactccacca gatagcagag gggtaagaga ggatgtgcaa     1440

gcgacgacag atgctaaaat ccctggatca cgacgctgca gagcaccttt gcacaggatg     1500

ctggcctttg ctcttactac actgaggaga gattcccgcg ggttccgcag gcagactaca     1560

caggatgagg tggtggagtg gagtgagagc aattgtaacg gttaactgta acgttttctt     1620

tcacacacac acacacacac acacacacac atgctaggat gcggaaatcc ccttatgact     1680

tgctactttt tgattttgtg atattttgta ctttttagtt gttcagcaac tgtcttattt     1740

aatggggaga ttttaagtaa cataactagt ggctctcagt taaaatgtga ggaagaacta     1800

cagctcttaa atgtagcaat ggcactgttg caaactcagt gcaaacgcct agattgcttt     1860

cttcttaacc tatttatttc tttgttaaat ttttctgatt gtttccttta tagagtgtct     1920

cagggtgcag aggtcagact aagaaatatt ccaaatgtct tttagaagat agatgcactt     1980

atgcagtaaa ttatcttggg atagttccca aaagattgct gaaaaagtag attgagtata     2040

aaaacttgaa aatatatgat ggctcgtggg atgtcctact atcactgaac aaactaaagg     2100

tgcactgctt tgggatttaa tttccagggt tgcttgatca ttatatcatt ggaacaactg     2160

atacttcact actttaataa agaattaaca gagattgaac tccaagaggt gggtaatttg     2220

gtttaaaaat acatgttcat gggtttacca ctaactcctg agaaatgtta aaggttcaca     2280

ggggttccct tctctcaatg tttgtaataa ttgctcataa gcaataccag caattcataa     2340

aaactgctta cttatgccat agaaaattaa acacaaagtg tatacatgta ttatgcttct     2400

aaatgctcat tctaccagat acacatttaa aagagaaaaa aggaacagaa acaagtcatt     2460

tgagagtgga gacttataag aaggagtaca tttgagttga atacacaaat ctttacttct     2520

ctaccaattc ctattcccaa aatgaacata ttactgggga aagttagttg agaatcagag     2580

catatgttat tggggaaagg atatgtttat tgacacataa tctgtaccag gtatgcatta     2640

aaatatattt gttaatttaa tatttaaacc tgagagatag gtattgtttc ccagatgagg     2700

acaatgaggc aaagaaatat caagtaactt gccaaaggtt acaagatatt cattccatgg     2760

atgcacaaag aagtgcatct agttccacag ctgattatgg ttgtcttgct tttcttccca     2820

ttgcaccagc ttgtcctcca aaatcatgaa tgatacacat gaagataact ttttttaaaa     2880

aaaagcagaa atacacaatg atctcccttg taagctccta aggtggcttt tctttctcta     2940

acttctagta aatataaacg gtttgtttga aaactatttt aaaatgtcaa caatatggag     3000

aataaccccc cccaacacac ctataaaaac ccaaattttt ggaacaaaga taatggaacc     3060

tccattttca aactgaagca cagggacaga aaatatattt ctagttatca cttaagcact     3120

caatcattag aggctacaag aataatattt ttaaagttac agtattttac aattattaga     3180

aaacattcta tataaaagaa gtcagttgat actttaaaat ctcccatttg gtttataaaa     3240

tcccttaatt tgacctctat atcttaaatt ccaagatgtt taaatttgct agttgcatta     3300

tactgggtca tgaaaaatta tcccttgaaa tagatatgaa acatgttact tcatttctgg     3360

tttaaataac ttgtggaatc tttcctaatg acaacctgat attaagggaa actaaagaaa     3420

atgttattgt ggatcccaca gtactatatt acactgtttt ttttgtttgt tttgttagtt     3480

ttttttattt aaagcaaacc tcaaacatta ttgggtatca attaccacct ggttgtattg     3540

aaatagtaac ttatcaatgc catgtaaaaa ttaattccat tttcgaagcc acctggcaga     3600

caggtttagc tgtttcatca gcagcctaat atatactgtt aaatttgtta aggatttcac     3660

tttgaaggat acatgcaaaa catatagtta ctattttcat gagtcctgct tctagctcca     3720

ttgtggaata cagaaaatta aatatacctg ttaagttcgt atctaaacct aagacattac     3780

caaggtttgt acaaattcta ctacctgaca tttattccaa gaagatctgg aaagttaaat     3840

aaatttataa atttaataac aaaaaaaaaa aaaaaaaa                             3878


<210>  57
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Arg Glu Glu Asn Lys Gly Met Pro Ser Gly Gly Gly Ser Asp Glu 
1               5                   10                  15      


Gly Leu Ala Ser Ala Ala Ala Arg Gly Leu Val Glu Lys Val Arg Gln 
            20                  25                  30          


Leu Leu Glu Ala Gly Ala Asp Pro Asn Gly Val Asn Arg Phe Gly Arg 
        35                  40                  45              


Arg Ala Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu 
    50                  55                  60                  


Leu Leu Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu 
65                  70                  75                  80  


Thr Arg Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu 
                85                  90                  95      


Val Val Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp 
            100                 105                 110         


Gly Arg Leu Pro Val Asp Leu Ala Glu Glu Arg Gly His Arg Asp Val 
        115                 120                 125             


Ala Gly Tyr Leu Arg Thr Ala Thr Gly Asp 
    130                 135             


<210>  58
<211>  1474
<212>  DNA
<213>  Homo sapiens

<400>  58
agccctccca gtttccgcgc gcctctttgg cagctggtca catggtgagg gtgggggtga       60

gggggcctct ctagcttgcg gcctgtgtct atggtcgggc cctctgcgtc cagctgctcc      120

ggaccgagct cgggtgtatg gggccgtagg aaccggctcc ggggccccga taacgggccg      180

cccccacagc accccgggct ggcgtgaggg tctcccttga tctgagaatg gctacctctc      240

gatatgagcc agtggctgaa attggtgtcg gtgcctatgg gacagtgtac aaggcccgtg      300

atccccacag tggccacttt gtggccctca agagtgtgag agtccccaat ggaggaggag      360

gtggaggagg ccttcccatc agcacagttc gtgaggtggc tttactgagg cgactggagg      420

cttttgagca tcccaatgtt gtccggctga tggacgtctg tgccacatcc cgaactgacc      480

gggagatcaa ggtaaccctg gtgtttgagc atgtagacca ggacctaagg acatatctgg      540

acaaggcacc cccaccaggc ttgccagccg aaacgatcaa ggatctgatg cgccagtttc      600

taagaggcct agatttcctt catgccaatt gcatcgttca ccgagatctg aagccagaga      660

acattctggt gacaagtggt ggaacagtca agctggctga ctttggcctg gccagaatct      720

acagctacca gatggcactt acacccgtgg ttgttacact ctggtaccga gctcccgaag      780

ttcttctgca gtccacatat gcaacacctg tggacatgtg gagtgttggc tgtatctttg      840

cagagatgtt tcgtcgaaag cctctcttct gtggaaactc tgaagccgac cagttgggca      900

aaatctttga cctgattggg ctgcctccag aggatgactg gcctcgagat gtatccctgc      960

cccgtggagc ctttcccccc agagggcccc gcccagtgca gtcggtggta cctgagatgg     1020

aggagtcggg agcacagctg ctgctggaaa tgctgacttt taacccacac aagcgaatct     1080

ctgcctttcg agctctgcag cactcttatc tacataagga tgaaggtaat ccggagtgag     1140

caatggagtg gctgccatgg aaggaagaaa agctgccatt tcccttctgg acactgagag     1200

ggcaatcttt gcctttatct ctgaggctat ggagggtcct cctccatctt tctacagaga     1260

ttactttgct gccttaatga cattcccctc ccacctctcc ttttgaggct tctccttctc     1320

cttcccattt ctctacacta aggggtatgt tccctcttgt ccctttccct acctttatat     1380

ttggggtcct tttttataca ggaaaaacaa aacaaagaaa taatggtctt tttttttttt     1440

ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1474


<210>  59
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  60
<211>  752
<212>  DNA
<213>  Homo sapiens

<400>  60
atcctcgtgg gccctgacct tctctctgag agccgggcag aggctccgga gccatgcagg       60

ccgaaggccg gggcacaggg ggttcgacgg gcgatgctga tggcccagga ggccctggca      120

ttcctgatgg cccagggggc aatgctggcg gcccaggaga ggcgggtgcc acgggcggca      180

gaggtccccg gggcgcaggg gcagcaaggg cctcggggcc gggaggaggc gccccgcggg      240

gtccgcatgg cggcgcggct tcagggctga atggatgctg cagatgcggg gccagggggc      300

cggagagccg cctgcttgag ttctacctcg ccatgccttt cgcgacaccc atggaagcag      360

agctggcccg caggagcctg gcccaggatg ccccaccgct tcccgtgcca ggggtgcttc      420

tgaaggagtt cactgtgtcc ggcaacatac tgactatccg actgactgct gcagaccacc      480

gccaactgca gctctccatc agctcctgtc tccagcagct ttccctgttg atgtggatca      540

cgcagtgctt tctgcccgtg tttttggctc agcctccctc agggcagagg cgctaagccc      600

agcctggcgc cccttcctag gtcatgcctc ctcccctagg gaatggtccc agcacgagtg      660

gccagttcat tgtgggggcc tgattgtttg tcgctggagg aggacggctt acatgtttgt      720

ttctgtagaa aataaaactg agctacgaaa aa                                    752


<210>  61
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  62
<211>  1755
<212>  DNA
<213>  Homo sapiens

<400>  62
agagagaagc gaggtttcca ttctgaggga cggcgtagag ttcggccgaa ggaacctgac       60

ccaggctctg tgaggaggca aggttttcag gggacaggcc aacccagagg acaggattcc      120

ctggaggcca cagaggagca ccaaggagaa gatctgcctg tgggtcttca ttgcccagct      180

cctgcccaca ctcctgcctg ctgccctgac gagagtcatc atgtctcttg agcagaggag      240

tctgcactgc aagcctgagg aagcccttga ggcccaacaa gaggccctgg gcctggtgtg      300

tgtgcaggct gccacctcct cctcctctcc tctggtcctg ggcaccctgg aggaggtgcc      360

cactgctggg tcaacagatc ctccccagag tcctcaggga gcctccgcct ttcccactac      420

catcaacttc actcgacaga ggcaacccag tgagggttcc agcagccgtg aagaggaggg      480

gccaagcacc tcttgtatcc tggagtcctt gttccgagca gtaatcacta agaaggtggc      540

tgatttggtt ggttttctgc tcctcaaata tcgagccagg gagccagtca caaaggcaga      600

aatgctggag agtgtcatca aaaattacaa gcactgtttt cctgagatct tcggcaaagc      660

ctctgagtcc ttgcagctgg tctttggcat tgacgtgaag gaagcagacc ccaccggcca      720

ctcctatgtc cttgtcacct gcctaggtct ctcctatgat ggcctgctgg gtgataatca      780

gatcatgccc aagacaggct tcctgataat tgtcctggtc atgattgcaa tggagggcgg      840

ccatgctcct gaggaggaaa tctgggagga gctgagtgtg atggaggtgt atgatgggag      900

ggagcacagt gcctatgggg agcccaggaa gctgctcacc caagatttgg tgcaggaaaa      960

gtacctggag taccggcagg tgccggacag tgatcccgca cgctatgagt tcctgtgggg     1020

tccaagggcc ctcgctgaaa ccagctatgt gaaagtcctt gagtatgtga tcaaggtcag     1080

tgcaagagtt cgctttttct tcccatccct gcgtgaagca gctttgagag aggaggaaga     1140

gggagtctga gcatgagttg cagccaaggc cagtgggagg gggactgggc cagtgcacct     1200

tccagggccg cgtccagcag cttcccctgc ctcgtgtgac atgaggccca ttcttcactc     1260

tgaagagagc ggtcagtgtt ctcagtagta ggtttctgtt ctattgggtg acttggagat     1320

ttatctttgt tctcttttgg aattgttcaa atgttttttt ttaagggatg gttgaatgaa     1380

cttcagcatc caagtttatg aatgacagca gtcacacagt tctgtgtata tagtttaagg     1440

gtaagagtct tgtgttttat tcagattggg aaatccattc tattttgtga attgggataa     1500

taacagcagt ggaataagta cttagaaatg tgaaaaatga gcagtaaaat agatgagata     1560

aagaactaaa gaaattaaga gatagtcaat tcttgcctta tacctcagtc tattctgtaa     1620

aatttttaaa gatatatgca tacctggatt tccttggctt ctttgagaat gtaagagaaa     1680

ttaaatctga ataaagaatt cttcctgtta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaa                                                      1755


<210>  63
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  64
<211>  2495
<212>  DNA
<213>  Homo sapiens

<400>  64
gcggctgcgg ggttcctggt gctgaggacg gacgccattg gagttcccga gaagcatggc       60

tgagggaagc ttcagcgtgc aatcggaaag ctacagtgtt gaagacatgg atgagggtag      120

cgacgaagtc ggggaggaag agatggttga aggcaacgac tatgaagaat tcggtgcgtt      180

tggtggctat ggcaccctca ccagctttga catccatatc ctcagagcct tcggaagctt      240

gggtccaggc cttcgcatct tatcgaatga gccctgggaa ctggaaaacc ctgtgctggc      300

ccagaccctg gtggaggcat tgcagctgga tccggaaaca cttgccaatg agacggccgc      360

ccgtgctgcc aacgtagccc gcgccgccgc ctccaaccgt gcggctcggg ccgctgccgc      420

cgctgcccgt accgccttca gtcaggtggt cgctagccac cgggtggcca cgccgcaggt      480

ctcaggagag gatacccagc ccacgaccta cgccgccgag gctcaggggc ccacccctga      540

gccacccctt gcttctccgc agacctccca gatgttagtc accagtaaga tggctgcccc      600

cgaggctccg gcaacctccg cacagtccca gacaggctcc ccggcccagg aggctgctac      660

tgagggccct agtagcgcct gtgctttctc tcaggctccg tgtgccaggg aggtggacgc      720

caaccggccc agcacagcct tcctgggcca gaatgatgtc ttcgatttca ctcagccggc      780

aggtgtcagt ggcatggcct tcccgcgccc caagagacct gccccagccc aagaggctgc      840

cacagagggc cccagtgctg cctctggtgt gccccagacg ggacctggca gggaggtggc      900

agccacccgg cccaagacca ccaagtcggg gaaggcgctg gccaagactc ggtgggtgga      960

gcctcagaat gttgtggcag cagctgctgc caaggccaag atggccacga gcatccctga     1020

gccggagggt gcagctgctg ccactgctca gcacagtgct gagccctggg ccaggatggg     1080

aggcaagagg accaagaagt ccaagcacct ggatgatgag tatgagagca gcgaggagga     1140

gagagagact cccgcggtcc cacccacctg gagagcatca cagccctcat tgacggtgcg     1200

ggctcagttg gcccctcggc ccccgatggc cccgaggtcc cagataccct caaggcacgt     1260

actgtgcctg cccccccgca acgtgaccct tctgcaggag agggcaaata agttggtgaa     1320

atacctgatg attaaggact acaagaagat ccccatcaag cgcgcagaca tgctgaagga     1380

tgtcatcaga gaatatgatg aacatttccc tgagatcatt gaacgagcaa cgtacaccct     1440

ggaaaagaag tttgggatcc acctgaagga gatcgacaag gaagaacacc tgtatattct     1500

tgtctgcaca cgggactcct cagctcgcct ccttggaaaa accaaggaca ctcccaggct     1560

gagtctcctc ttggtgattc tgggcgtcat cttcatgaat ggcaaccgtg ccagcgaggc     1620

tgtcctctgg gaggcactac gcaagatggg actgcgccct ggggtgaggc acccattcct     1680

cggcgatctg aggaagctca tcacagatga ctttgtgaag cagaagtacc tggaatacaa     1740

gaagatcccc aacagcaacc cacctgagta tgaattcctc tggggcctgc gagcccgcca     1800

tgagaccagc aagatgaggg tcctgagatt catcgcccag aatcagaacc gagacccccg     1860

ggaatggaag gctcatttct tggaggctgt ggatgatgct ttcaagacaa tggatgtgga     1920

tatggccgag gaacatgcca gggcccagat gagggcccag atgaatatcg gggatgaagc     1980

gctgattgga cggtggagct gggatgacat acaagtcgag ctcctgacct gggatgagga     2040

cggagatttt ggcgatgcct gggccaggat cccctttgct ttctgggcca gataccatca     2100

gtacattctg aatagcaacc gtgccaacag gagggccacg tggagagctg gcgtcagcag     2160

tggcaccaat ggaggggcca gcaccagcgt cctagatggc cccagcacca gctccaccat     2220

ccggaccaga aatgctgcca gagctggcgc cagcttcttc tcctggatcc agtaagagtt     2280

tcggcaccgt tgacgaactg cagcgatctt actggccaag ccagagcgcc tcctctcaga     2340

ttccttctcg acacagcacc ctaggcggct tcttcctgtc agtcggaggt ggcatgcaag     2400

atgaagctct ctttgctctt cctgctttca ttttgtgctt ttccttgtgt tttcatgttt     2460

tgggtatcag tgttacatta aagttgcaaa attaa                                2495


<210>  65
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Glu Gly Ser Phe Ser Val Gln Ser Glu Ser Tyr Ser Val Glu 
1               5                   10                  15      


Asp Met Asp Glu Gly Ser Asp Glu Val Gly Glu Glu Glu Met Val Glu 
            20                  25                  30          


Gly Asn Asp Tyr Glu Glu Phe Gly Ala Phe Gly Gly Tyr Gly Thr Leu 
        35                  40                  45              


Thr Ser Phe Asp Ile His Ile Leu Arg Ala Phe Gly Ser Leu Gly Pro 
    50                  55                  60                  


Gly Leu Arg Ile Leu Ser Asn Glu Pro Trp Glu Leu Glu Asn Pro Val 
65                  70                  75                  80  


Leu Ala Gln Thr Leu Val Glu Ala Leu Gln Leu Asp Pro Glu Thr Leu 
                85                  90                  95      


Ala Asn Glu Thr Ala Ala Arg Ala Ala Asn Val Ala Arg Ala Ala Ala 
            100                 105                 110         


Ser Asn Arg Ala Ala Arg Ala Ala Ala Ala Ala Ala Arg Thr Ala Phe 
        115                 120                 125             


Ser Gln Val Val Ala Ser His Arg Val Ala Thr Pro Gln Val Ser Gly 
    130                 135                 140                 


Glu Asp Thr Gln Pro Thr Thr Tyr Ala Ala Glu Ala Gln Gly Pro Thr 
145                 150                 155                 160 


Pro Glu Pro Pro Leu Ala Ser Pro Gln Thr Ser Gln Met Leu Val Thr 
                165                 170                 175     


Ser Lys Met Ala Ala Pro Glu Ala Pro Ala Thr Ser Ala Gln Ser Gln 
            180                 185                 190         


Thr Gly Ser Pro Ala Gln Glu Ala Ala Thr Glu Gly Pro Ser Ser Ala 
        195                 200                 205             


Cys Ala Phe Ser Gln Ala Pro Cys Ala Arg Glu Val Asp Ala Asn Arg 
    210                 215                 220                 


Pro Ser Thr Ala Phe Leu Gly Gln Asn Asp Val Phe Asp Phe Thr Gln 
225                 230                 235                 240 


Pro Ala Gly Val Ser Gly Met Ala Phe Pro Arg Pro Lys Arg Pro Ala 
                245                 250                 255     


Pro Ala Gln Glu Ala Ala Thr Glu Gly Pro Ser Ala Ala Ser Gly Val 
            260                 265                 270         


Pro Gln Thr Gly Pro Gly Arg Glu Val Ala Ala Thr Arg Pro Lys Thr 
        275                 280                 285             


Thr Lys Ser Gly Lys Ala Leu Ala Lys Thr Arg Trp Val Glu Pro Gln 
    290                 295                 300                 


Asn Val Val Ala Ala Ala Ala Ala Lys Ala Lys Met Ala Thr Ser Ile 
305                 310                 315                 320 


Pro Glu Pro Glu Gly Ala Ala Ala Ala Thr Ala Gln His Ser Ala Glu 
                325                 330                 335     


Pro Trp Ala Arg Met Gly Gly Lys Arg Thr Lys Lys Ser Lys His Leu 
            340                 345                 350         


Asp Asp Glu Tyr Glu Ser Ser Glu Glu Glu Arg Glu Thr Pro Ala Val 
        355                 360                 365             


Pro Pro Thr Trp Arg Ala Ser Gln Pro Ser Leu Thr Val Arg Ala Gln 
    370                 375                 380                 


Leu Ala Pro Arg Pro Pro Met Ala Pro Arg Ser Gln Ile Pro Ser Arg 
385                 390                 395                 400 


His Val Leu Cys Leu Pro Pro Arg Asn Val Thr Leu Leu Gln Glu Arg 
                405                 410                 415     


Ala Asn Lys Leu Val Lys Tyr Leu Met Ile Lys Asp Tyr Lys Lys Ile 
            420                 425                 430         


Pro Ile Lys Arg Ala Asp Met Leu Lys Asp Val Ile Arg Glu Tyr Asp 
        435                 440                 445             


Glu His Phe Pro Glu Ile Ile Glu Arg Ala Thr Tyr Thr Leu Glu Lys 
    450                 455                 460                 


Lys Phe Gly Ile His Leu Lys Glu Ile Asp Lys Glu Glu His Leu Tyr 
465                 470                 475                 480 


Ile Leu Val Cys Thr Arg Asp Ser Ser Ala Arg Leu Leu Gly Lys Thr 
                485                 490                 495     


Lys Asp Thr Pro Arg Leu Ser Leu Leu Leu Val Ile Leu Gly Val Ile 
            500                 505                 510         


Phe Met Asn Gly Asn Arg Ala Ser Glu Ala Val Leu Trp Glu Ala Leu 
        515                 520                 525             


Arg Lys Met Gly Leu Arg Pro Gly Val Arg His Pro Phe Leu Gly Asp 
    530                 535                 540                 


Leu Arg Lys Leu Ile Thr Asp Asp Phe Val Lys Gln Lys Tyr Leu Glu 
545                 550                 555                 560 


Tyr Lys Lys Ile Pro Asn Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp 
                565                 570                 575     


Gly Leu Arg Ala Arg His Glu Thr Ser Lys Met Arg Val Leu Arg Phe 
            580                 585                 590         


Ile Ala Gln Asn Gln Asn Arg Asp Pro Arg Glu Trp Lys Ala His Phe 
        595                 600                 605             


Leu Glu Ala Val Asp Asp Ala Phe Lys Thr Met Asp Val Asp Met Ala 
    610                 615                 620                 


Glu Glu His Ala Arg Ala Gln Met Arg Ala Gln Met Asn Ile Gly Asp 
625                 630                 635                 640 


Glu Ala Leu Ile Gly Arg Trp Ser Trp Asp Asp Ile Gln Val Glu Leu 
                645                 650                 655     


Leu Thr Trp Asp Glu Asp Gly Asp Phe Gly Asp Ala Trp Ala Arg Ile 
            660                 665                 670         


Pro Phe Ala Phe Trp Ala Arg Tyr His Gln Tyr Ile Leu Asn Ser Asn 
        675                 680                 685             


Arg Ala Asn Arg Arg Ala Thr Trp Arg Ala Gly Val Ser Ser Gly Thr 
    690                 695                 700                 


Asn Gly Gly Ala Ser Thr Ser Val Leu Asp Gly Pro Ser Thr Ser Ser 
705                 710                 715                 720 


Thr Ile Arg Thr Arg Asn Ala Ala Arg Ala Gly Ala Ser Phe Phe Ser 
                725                 730                 735     


Trp Ile Gln 
            


<210>  66
<211>  1753
<212>  DNA
<213>  Homo sapiens

<400>  66
gagattctcg ccctgagcaa cgagcgacgg cctgacgtcg gcggagggaa gccggcccag       60

gctcggtgag gaggcaaggt tctgagggga caggctgacc tggaggacca gaggcccccg      120

gaggagcact gaaggagaag atctgccagt gggtctccat tgcccagctc ctgcccacac      180

tcccgcctgt tgccctgacc agagtcatca tgcctcttga gcagaggagt cagcactgca      240

agcctgaaga aggccttgag gcccgaggag aggccctggg cctggtgggt gcgcaggctc      300

ctgctactga ggagcaggag gctgcctcct cctcttctac tctagttgaa gtcaccctgg      360

gggaggtgcc tgctgccgag tcaccagatc ctccccagag tcctcaggga gcctccagcc      420

tccccactac catgaactac cctctctgga gccaatccta tgaggactcc agcaaccaag      480

aagaggaggg gccaagcacc ttccctgacc tggagtccga gttccaagca gcactcagta      540

ggaaggtggc cgagttggtt cattttctgc tcctcaagta tcgagccagg gagccggtca      600

caaaggcaga aatgctgggg agtgtcgtcg gaaattggca gtatttcttt cctgtgatct      660

tcagcaaagc ttccagttcc ttgcagctgg tctttggcat cgagctgatg gaagtggacc      720

ccatcggcca cttgtacatc tttgccacct gcctgggcct ctcctacgat ggcctgctgg      780

gtgacaatca gatcatgccc aaggcaggcc tcctgataat cgtcctggcc ataatcgcaa      840

gagagggcga ctgtgcccct gaggagaaaa tctgggagga gctgagtgtg ttagaggtgt      900

ttgaggggag ggaagacagt atcttggggg atcccaagaa gctgctcacc caacatttcg      960

tgcaggaaaa ctacctggag taccggcagg tccccggcag tgatcctgca tgttatgaat     1020

tcctgtgggg tccaagggcc ctcgttgaaa ccagctatgt gaaagtcctg caccatatgg     1080

taaagatcag tggaggacct cacatttcct acccacccct gcatgagtgg gttttgagag     1140

agggggaaga gtgagtctga gcacgagttg cagccagggc cagtgggagg gggtctgggc     1200

cagtgcacct tccggggccg catcccttag tttccactgc ctcctgtgac gtgaggccca     1260

ttcttcactc tttgaagcga gcagtcagca ttcttagtag tgggtttctg ttctgttgga     1320

tgactttgag attattcttt gtttcctgtt ggagttgttc aaatgttcct tttaacggat     1380

ggttgaatga gcgtcagcat ccaggtttat gaatgacagt agtcacacat agtgctgttt     1440

atatagttta ggagtaagag tcttgttttt tactcaaatt gggaaatcca ttccattttg     1500

tgaattgtga cataataata gcagtggtaa aagtatttgc ttaaaattgt gagcgaatta     1560

gcaataacat acatgagata actcaagaaa tcaaaagata gttgattctt gccttgtacc     1620

tcaatctatt ctgtaaaatt aaacaaatat gcaaaccagg atttccttga cttctttgag     1680

aatgcaagcg aaattaaatc tgaataaata attcttcctc ttcaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaa                                                        1753


<210>  67
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  68
<211>  2126
<212>  DNA
<213>  Homo sapiens

<400>  68
gccaggctct ccacccccac ttcccaattg aggaaaccga ggcagaggag gctcagagag       60

ctaccggtgg acccacggtg cctccctccc tgggatctac acagaccatg gccttgccaa      120

cggctcgacc cctgttgggg tcctgtggga cccccgccct cggcagcctc ctgttcctgc      180

tcttcagcct cggatgggtg cagccctcga ggaccctggc tggagagaca gggcaggagg      240

ctgcgcccct ggacggagtc ctggccaacc cacctaacat ttccagcctc tcccctcgcc      300

aactccttgg cttcccgtgt gcggaggtgt ccggcctgag cacggagcgt gtccgggagc      360

tggctgtggc cttggcacag aagaatgtca agctctcaac agagcagctg cgctgtctgg      420

ctcaccggct ctctgagccc cccgaggacc tggacgccct cccattggac ctgctgctat      480

tcctcaaccc agatgcgttc tcggggcccc aggcctgcac ccgtttcttc tcccgcatca      540

cgaaggccaa tgtggacctg ctcccgaggg gggctcccga gcgacagcgg ctgctgcctg      600

cggctctggc ctgctggggt gtgcgggggt ctctgctgag cgaggctgat gtgcgggctc      660

tgggaggcct ggcttgcgac ctgcctgggc gctttgtggc cgagtcggcc gaagtgctgc      720

taccccggct ggtgagctgc ccgggacccc tggaccagga ccagcaggag gcagccaggg      780

cggctctgca gggcggggga cccccctacg gccccccgtc gacatggtct gtctccacga      840

tggacgctct gcggggcctg ctgcccgtgc tgggccagcc catcatccgc agcatcccgc      900

agggcatcgt ggccgcgtgg cggcaacgct cctctcggga cccatcctgg cggcagcctg      960

aacggaccat cctccggccg cggttccggc gggaagtgga gaagacagcc tgtccttcag     1020

gcaagaaggc ccgcgagata gacgagagcc tcatcttcta caagaagtgg gagctggaag     1080

cctgcgtgga tgcggccctg ctggccaccc agatggaccg cgtgaacgcc atccccttca     1140

cctacgagca gctggacgtc ctaaagcata aactggatga gctctaccca caaggttacc     1200

ccgagtctgt gatccagcac ctgggctacc tcttcctcaa gatgagccct gaggacattc     1260

gcaagtggaa tgtgacgtcc ctggagaccc tgaaggcttt gcttgaagtc aacaaagggc     1320

acgaaatgag tcctcaggtg gccaccctga tcgaccgctt tgtgaaggga aggggccagc     1380

tagacaaaga caccctagac accctgaccg ccttctaccc tgggtacctg tgctccctca     1440

gccccgagga gctgagctcc gtgcccccca gcagcatctg ggcggtcagg ccccaggacc     1500

tggacacgtg tgacccaagg cagctggacg tcctctatcc caaggcccgc cttgctttcc     1560

agaacatgaa cgggtccgaa tacttcgtga agatccagtc cttcctgggt ggggccccca     1620

cggaggattt gaaggcgctc agtcagcaga atgtgagcat ggacttggcc acgttcatga     1680

agctgcggac ggatgcggtg ctgccgttga ctgtggctga ggtgcagaaa cttctgggac     1740

cccacgtgga gggcctgaag gcggaggagc ggcaccgccc ggtgcgggac tggatcctac     1800

ggcagcggca ggacgacctg gacacgctgg ggctggggct acagggcggc atccccaacg     1860

gctacctggt cctagacctc agcatgcaag aggccctctc ggggacgccc tgcctcctag     1920

gacctggacc tgttctcacc gtcctggcac tgctcctagc ctccaccctg gcctgagggc     1980

cccactccct tgctggcccc agccctgctg gggatccccg cctggccagg agcaggcacg     2040

ggtggtcccc gttccacccc aagagaactc gcgctcagta aacgggaaca tgccccctgc     2100

agacacgtaa aaaaaaaaaa aaaaaa                                          2126


<210>  69
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  70
<211>  2082
<212>  DNA
<213>  Homo sapiens

<400>  70
atcactgtag tagtagctgg aaagagaaat ctgtgactcc aattagccag ttcctgcaga       60

ccttgtgagg actagaggaa gaatgctcct ggctgttttg tactgcctgc tgtggagttt      120

ccagacctcc gctggccatt tccctagagc ctgtgtctcc tctaagaacc tgatggagaa      180

ggaatgctgt ccaccgtgga gcggggacag gagtccctgt ggccagcttt caggcagagg      240

ttcctgtcag aatatccttc tgtccaatgc accacttggg cctcaatttc ccttcacagg      300

ggtggatgac cgggagtcgt ggccttccgt cttttataat aggacctgcc agtgctctgg      360

caacttcatg ggattcaact gtggaaactg caagtttggc ttttggggac caaactgcac      420

agagagacga ctcttggtga gaagaaacat cttcgatttg agtgccccag agaaggacaa      480

attttttgcc tacctcactt tagcaaagca taccatcagc tcagactatg tcatccccat      540

agggacctat ggccaaatga aaaatggatc aacacccatg tttaacgaca tcaatattta      600

tgacctcttt gtctggatgc attattatgt gtcaatggat gcactgcttg ggggatctga      660

aatctggaga gacattgatt ttgcccatga agcaccagct tttctgcctt ggcatagact      720

cttcttgttg cggtgggaac aagaaatcca gaagctgaca ggagatgaaa acttcactat      780

tccatattgg gactggcggg atgcagaaaa gtgtgacatt tgcacagatg agtacatggg      840

aggtcagcac cccacaaatc ctaacttact cagcccagca tcattcttct cctcttggca      900

gattgtctgt agccgattgg aggagtacaa cagccatcag tctttatgca atggaacgcc      960

cgagggacct ttacggcgta atcctggaaa ccatgacaaa tccagaaccc caaggctccc     1020

ctcttcagct gatgtagaat tttgcctgag tttgacccaa tatgaatctg gttccatgga     1080

taaagctgcc aatttcagct ttagaaatac actggaagga tttgctagtc cacttactgg     1140

gatagcggat gcctctcaaa gcagcatgca caatgccttg cacatctata tgaatggaac     1200

aatgtcccag gtacagggat ctgccaacga tcctatcttc cttcttcacc atgcatttgt     1260

tgacagtatt tttgagcagt ggctccgaag gcaccgtcct cttcaagaag tttatccaga     1320

agccaatgca cccattggac ataaccggga atcctacatg gttcctttta taccactgta     1380

cagaaatggt gatttcttta tttcatccaa agatctgggc tatgactata gctatctaca     1440

agattcagac ccagactctt ttcaagacta cattaagtcc tatttggaac aagcgagtcg     1500

gatctggtca tggctccttg gggcggcgat ggtaggggcc gtcctcactg ccctgctggc     1560

agggcttgtg agcttgctgt gtcgtcacaa gagaaagcag cttcctgaag aaaagcagcc     1620

actcctcatg gagaaagagg attaccacag cttgtatcag agccatttat aaaaggctta     1680

ggcaatagag tagggccaaa aagcctgacc tcactctaac tcaaagtaat gtccaggttc     1740

ccagagaata tctgctggta tttttctgta aagaccattt gcaaaattgt aacctaatac     1800

aaagtgtagc cttcttccaa ctcaggtaga acacacctgt ctttgtcttg ctgttttcac     1860

tcagcccttt taacattttc ccctaagccc atatgtctaa ggaaaggatg ctatttggta     1920

atgaggaact gttatttgta tgtgaattaa agtgctctta ttttaaaaaa ttgaaataat     1980

tttgattttt gccttctgat tatttaaaga tctatatatg ttttattggc cccttcttta     2040

ttttaataaa acagtgagaa atctaaaaaa aaaaaaaaaa aa                        2082


<210>  71
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  72
<211>  2876
<212>  DNA
<213>  Homo sapiens

<400>  72
acagttctga cgtgagagga caagaaacac aagcaaatat aaaacattca attctaagag       60

aagttcatca gagacatcct tcaggattgt gagctggatt ttcctctacg tgcttcagtc      120

ttctctacac aaagagctgc aaaccaggtc tttgttttgc actcttattt caagcagaat      180

gagtgctcct aaactcctct ctctgggctg tatcttcttc cccttgctac tttttcagca      240

ggcccgggct caattcccaa gacagtgtgc cactgttgag gctttgagaa gtggtatgtg      300

ttgcccagac ctgtcccctg tgtctgggcc tgggacagac cgctgtggct catcatcagg      360

gaggggcaga tgtgaggcag tgactgcaga ctcccggccc cacagccctc agtatcccca      420

tgatggcaga gatgatcggg aggtctggcc cttgcgcttc ttcaatagga catgtcactg      480

caacggcaat ttctcaggac acaactgtgg gacgtgccgt cctggctgga gaggagctgc      540

ctgtgaccag agggttctca tagtcaggag aaatcttctg gacttaagta aagaagaaaa      600

gaaccacttt gtccgggccc tggatatggc aaagcgcaca actcaccctt tatttgtcat      660

tgccaccagg agatcagaag aaatactggg gccagatggc aacacgccac aatttgagaa      720

catttccatt tataactact ttgtttggac acactattac tcagtcaaaa agactttcct      780

tggggtagga caggaaagct ttggtgaagt ggatttctct catgagggac cagcttttct      840

cacatggcac aggtaccacc tcctgcgtct ggagaaagac atgcaggaaa tgttgcaaga      900

gccttctttc tcccttcctt actggaattt tgcaacgggg aaaaatgtct gtgatatctg      960

cacggatgac ttgatgggat ccagaagcaa ctttgattcc actctaataa gcccaaactc     1020

tgtcttttct caatggcgag tggtctgtga ctccttggaa gattatgata ccctgggaac     1080

actttgtaac agcaccgagg atgggccaat taggagaaat ccagctggaa atgtggccag     1140

accaatggtg caacgtcttc ctgaaccaca ggatgtcgct cagtgcttgg aagttggttt     1200

atttgacacg cctccttttt attccaactc tacaaacagt ttccgaaaca cagtggaagg     1260

ttacagtgac cccacgggaa agtatgaccc tgctgttcga agtcttcaca atttggctca     1320

tctattcctg aatggaacag ggggacaaac ccatttgtct ccaaatgatc ctatttttgt     1380

cctcctgcac accttcacag atgcagtctt tgatgaatgg ctgaggagat acaatgctga     1440

tatatccaca tttccattgg aaaatgcccc tattggacat aatagacaat acaacatggt     1500

gccattctgg cccccagtca ccaacacaga aatgtttgtt actgctccag acaacctggg     1560

atacacttat gaaattcaat ggccaagtcg ggagtttagt gtacctgaga taattgccat     1620

agcagtagtt ggcgctttgt tactggttgc actcattttt gggactgctt cttatctgat     1680

tcgtgccaga cgcagtatgg atgaagctaa ccagcctctc ctcactgatc agtatcaatg     1740

ctatgctgaa gaatatgaaa aactccagaa tcctaatcag tctgtggtct aacaaatgcc     1800

ctactctctt atgcattagt atcacaaaac cacctggttg aatataatag attgagttat     1860

taactgtatt ttctttcact ttattacctt ctttctaata caagcatatg ttagcattaa     1920

agttctaggc atacttttca aagctgggaa gaccctttca gaatcttttc aatgggtttt     1980

aattttcagt tctatttaaa atggtgaatg acactaaact ccatgatatt taaggatagt     2040

gtgaagatct ttggcatgat ttaaaggttg agtatgtgaa gatataagta agtgaactac     2100

catgctttgt ttacgtgtaa aggaaaataa tgtttgatag taaatgtcca cttaaaatac     2160

atgaatgggc atttctaaaa tgttaaaaca taaacacatt tccattcatg gatatttgtc     2220

aacagattta aagaaaacca cagttattaa ttaaagaaaa ttaattatgt gtagttataa     2280

accaatgaaa ttttgattaa ccttttcaaa ttaatgttcc agtttgaaga ccaatcaaat     2340

atattattta gtcaacatat actatttagt ctcaggttca aggctacaac aaaaatcacc     2400

atctttgtca aactttggag agggaaaatc ttcactttct taagcaacaa tggatattgc     2460

ctgtgtttgc cactgtgttt ccctgcctct caattcgctg aaaaaggaac tacctatcct     2520

tacatttcac ctactaatgt ctcttctaac atcttagagg tccatggaga aggcatatgg     2580

agaacatgtt ttatactgct ctataaatag tattccaatc actgtgctta atttaaatag     2640

cattatctta tcatttatca gccttttatg tattttccaa gtaaaatatt aacatattat     2700

ttcattggtc ttctttttta tctggttcta tatgaatgct attttttccc ttctcttcta     2760

acatgaaata tattttctct ttttgatctt gtgctatgaa acaatcttcc aaagaactgt     2820

ataaggtggt cataagtgaa tattttaatt aaaattggta aaaataaata ataaca         2876


<210>  73
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ser Ala Pro Lys Leu Leu Ser Leu Gly Cys Ile Phe Phe Pro Leu 
1               5                   10                  15      


Leu Leu Phe Gln Gln Ala Arg Ala Gln Phe Pro Arg Gln Cys Ala Thr 
            20                  25                  30          


Val Glu Ala Leu Arg Ser Gly Met Cys Cys Pro Asp Leu Ser Pro Val 
        35                  40                  45              


Ser Gly Pro Gly Thr Asp Arg Cys Gly Ser Ser Ser Gly Arg Gly Arg 
    50                  55                  60                  


Cys Glu Ala Val Thr Ala Asp Ser Arg Pro His Ser Pro Gln Tyr Pro 
65                  70                  75                  80  


His Asp Gly Arg Asp Asp Arg Glu Val Trp Pro Leu Arg Phe Phe Asn 
                85                  90                  95      


Arg Thr Cys His Cys Asn Gly Asn Phe Ser Gly His Asn Cys Gly Thr 
            100                 105                 110         


Cys Arg Pro Gly Trp Arg Gly Ala Ala Cys Asp Gln Arg Val Leu Ile 
        115                 120                 125             


Val Arg Arg Asn Leu Leu Asp Leu Ser Lys Glu Glu Lys Asn His Phe 
    130                 135                 140                 


Val Arg Ala Leu Asp Met Ala Lys Arg Thr Thr His Pro Leu Phe Val 
145                 150                 155                 160 


Ile Ala Thr Arg Arg Ser Glu Glu Ile Leu Gly Pro Asp Gly Asn Thr 
                165                 170                 175     


Pro Gln Phe Glu Asn Ile Ser Ile Tyr Asn Tyr Phe Val Trp Thr His 
            180                 185                 190         


Tyr Tyr Ser Val Lys Lys Thr Phe Leu Gly Val Gly Gln Glu Ser Phe 
        195                 200                 205             


Gly Glu Val Asp Phe Ser His Glu Gly Pro Ala Phe Leu Thr Trp His 
    210                 215                 220                 


Arg Tyr His Leu Leu Arg Leu Glu Lys Asp Met Gln Glu Met Leu Gln 
225                 230                 235                 240 


Glu Pro Ser Phe Ser Leu Pro Tyr Trp Asn Phe Ala Thr Gly Lys Asn 
                245                 250                 255     


Val Cys Asp Ile Cys Thr Asp Asp Leu Met Gly Ser Arg Ser Asn Phe 
            260                 265                 270         


Asp Ser Thr Leu Ile Ser Pro Asn Ser Val Phe Ser Gln Trp Arg Val 
        275                 280                 285             


Val Cys Asp Ser Leu Glu Asp Tyr Asp Thr Leu Gly Thr Leu Cys Asn 
    290                 295                 300                 


Ser Thr Glu Asp Gly Pro Ile Arg Arg Asn Pro Ala Gly Asn Val Ala 
305                 310                 315                 320 


Arg Pro Met Val Gln Arg Leu Pro Glu Pro Gln Asp Val Ala Gln Cys 
                325                 330                 335     


Leu Glu Val Gly Leu Phe Asp Thr Pro Pro Phe Tyr Ser Asn Ser Thr 
            340                 345                 350         


Asn Ser Phe Arg Asn Thr Val Glu Gly Tyr Ser Asp Pro Thr Gly Lys 
        355                 360                 365             


Tyr Asp Pro Ala Val Arg Ser Leu His Asn Leu Ala His Leu Phe Leu 
    370                 375                 380                 


Asn Gly Thr Gly Gly Gln Thr His Leu Ser Pro Asn Asp Pro Ile Phe 
385                 390                 395                 400 


Val Leu Leu His Thr Phe Thr Asp Ala Val Phe Asp Glu Trp Leu Arg 
                405                 410                 415     


Arg Tyr Asn Ala Asp Ile Ser Thr Phe Pro Leu Glu Asn Ala Pro Ile 
            420                 425                 430         


Gly His Asn Arg Gln Tyr Asn Met Val Pro Phe Trp Pro Pro Val Thr 
        435                 440                 445             


Asn Thr Glu Met Phe Val Thr Ala Pro Asp Asn Leu Gly Tyr Thr Tyr 
    450                 455                 460                 


Glu Ile Gln Trp Pro Ser Arg Glu Phe Ser Val Pro Glu Ile Ile Ala 
465                 470                 475                 480 


Ile Ala Val Val Gly Ala Leu Leu Leu Val Ala Leu Ile Phe Gly Thr 
                485                 490                 495     


Ala Ser Tyr Leu Ile Arg Ala Arg Arg Ser Met Asp Glu Ala Asn Gln 
            500                 505                 510         


Pro Leu Leu Thr Asp Gln Tyr Gln Cys Tyr Ala Glu Glu Tyr Glu Lys 
        515                 520                 525             


Leu Gln Asn Pro Asn Gln Ser Val Val 
    530                 535         


<210>  74
<211>  2403
<212>  DNA
<213>  Homo sapiens

<400>  74
aactgagttc aaggcaatta aagtcaagag ctaaggaggg agggagaggg tttagaaata       60

ccagcataat aagtagtatg actgggtgct ctgtaaatta actcaattag acaaagcctg      120

acttaacggg ggaagatggt gagaagcgct accctcatta aatttggttg ttagaggcgc      180

ttctaaggaa attaagtctg ttagttgttt gaatcacata aaattgtgtg tgcacgttca      240

tgtacacatg tgcacacatg taacctctgt gattcttgtg ggtatttttt taagaagaaa      300

ggaatagaaa gcaaagaaaa ataaaaaata ctgaaaagaa aagactgaaa gagtagaaga      360

taaggagaaa agtacgacag agacaaggaa agtaagagag agagagagct ctcccaatta      420

taaagccatg agcccccttt ggtgggggtt tctgctcagt tgcttgggct gcaaaatcct      480

gccaggagcc cagggtcagt tcccccgagt ctgcatgacg gtggacagcc tagtgaacaa      540

ggagtgctgc ccacgcctgg gtgcagagtc ggccaatgtc tgtggctctc agcaaggccg      600

ggggcagtgc acagaggtgc gagccgacac aaggccctgg agtggtccct acatcctacg      660

aaaccaggat gaccgtgagc tgtggccaag aaaattcttc caccggacct gcaagtgcac      720

aggaaacttt gccggctata attgtggaga ctgcaagttt ggctggaccg gtcccaactg      780

cgagcggaag aaaccaccag tgattcggca gaacatccat tccttgagtc ctcaggaaag      840

agagcagttc ttgggcgcct tagatctcgc gaagaagaga gtacaccccg actacgtgat      900

caccacacaa cactggctgg gcctgcttgg gcccaatgga acccagccgc agtttgccaa      960

ctgcagtgtt tatgattttt ttgtgtggct ccattattat tctgttagag atacattatt     1020

aggaccagga cgcccctaca gggccataga tttctcacat caaggacctg catttgttac     1080

ctggcaccgg taccatttgt tgtgtctgga aagagatctc cagcgactca ttggcaatga     1140

gtcttttgct ttgccctact ggaactttgc cactgggagg aacgagtgtg atgtgtgtac     1200

agaccagctg tttggggcag cgagaccaga cgatccgact ctgattagtc ggaactcaag     1260

attctccagc tgggaaactg tctgtgatag cttggatgac tacaaccacc tggtcacctt     1320

gtgcaatgga acctatgaag gtttgctgag aagaaatcaa atgggaagaa acagcatgaa     1380

attgccaacc ttaaaagaca tacgagattg cctgtctctc cagaagtttg acaatcctcc     1440

cttcttccag aactctacct tcagtttcag gaatgctttg gaagggtttg ataaagcaga     1500

tgggactctg gattctcaag tgatgagcct tcataatttg gttcattcct tcctgaacgg     1560

gacaaacgct ttgccacatt cagccgccaa tgatcccatt tttgtggtga tttctaatcg     1620

tttgctttac aatgctacaa caaacatcct tgaacatgta agaaaagaga aagcgaccaa     1680

ggaactccct tccctgcatg tgctggttct tcattccttt actgatgcca tctttgatga     1740

gtggatgaaa agatttaatc ctcctgcaga tgcctggcct caggagctgg cccctattgg     1800

tcacaatcgg atgtacaaca tggttccttt cttccctcca gtgactaatg aagaactctt     1860

tttaacctca gaccaacttg gctacagcta tgccatcgat ctgccagttt cagttgaaga     1920

aactccaggt tggcccacaa ctctcttagt agtcatggga acactggtgg ctttggttgg     1980

tctttttgtg ctgttggctt ttcttcaata tagaagactt cgaaaaggat atacacccct     2040

aatggagaca catttaagca gcaagagata cacagaagaa gcctagggtg ctcatgcctt     2100

acctaagaga agaggctggc caagccacag ttctgacgct gacaataaag gaactaatcc     2160

tcactgttcc ttcttgagtt gaagatcttt gacataggtt cttctatagt gatgatgatc     2220

tcattcagaa gatgcttagc tgtagtttcc gctttgcttg cttgtttaac aaacccaact     2280

aaagtgcttg aggctacctc taccttcaaa taaagataga cctgacaatt tgtgatatct     2340

aataataacc ccccccccaa tattgattaa gcctcctcct tttctgaaag catttaaaaa     2400

aaa                                                                   2403


<210>  75
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp Asn 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser Leu 
        355                 360                 365             


His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Ile Phe Val Val Ile Ser Asn Arg Leu Leu 
385                 390                 395                 400 


Tyr Asn Ala Thr Thr Asn Ile Leu Glu His Val Arg Lys Glu Lys Ala 
                405                 410                 415     


Thr Lys Glu Leu Pro Ser Leu His Val Leu Val Leu His Ser Phe Thr 
            420                 425                 430         


Asp Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp 
        435                 440                 445             


Ala Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn 
    450                 455                 460                 


Met Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr 
465                 470                 475                 480 


Ser Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val 
                485                 490                 495     


Glu Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr 
            500                 505                 510         


Leu Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr 
        515                 520                 525             


Arg Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser 
    530                 535                 540                 


Ser Lys Arg Tyr Thr Glu Glu Ala 
545                 550         


<210>  76
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  76
gcccgtacac accgtgtgct gggacacccc acagtcagcc gcatggctcc cctgtgcccc       60

agcccctggc tccctctgtt gatcccggcc cctgctccag gcctcactgt gcaactgctg      120

ctgtcactgc tgcttctgat gcctgtccat ccccagaggt tgccccggat gcaggaggat      180

tcccccttgg gaggaggctc ttctggggaa gatgacccac tgggcgagga ggatctgccc      240

agtgaagagg attcacccag agaggaggat ccacccggag aggaggatct acctggagag      300

gaggatctac ctggagagga ggatctacct gaagttaagc ctaaatcaga agaagagggc      360

tccctgaagt tagaggatct acctactgtt gaggctcctg gagatcctca agaaccccag      420

aataatgccc acagggacaa agaaggggat gaccagagtc attggcgcta tggaggcgac      480

ccgccctggc cccgggtgtc cccagcctgc gcgggccgct tccagtcccc ggtggatatc      540

cgcccccagc tcgccgcctt ctgcccggcc ctgcgccccc tggaactcct gggcttccag      600

ctcccgccgc tcccagaact gcgcctgcgc aacaatggcc acagtgtgca actgaccctg      660

cctcctgggc tagagatggc tctgggtccc gggcgggagt accgggctct gcagctgcat      720

ctgcactggg gggctgcagg tcgtccgggc tcggagcaca ctgtggaagg ccaccgtttc      780

cctgccgaga tccacgtggt tcacctcagc accgcctttg ccagagttga cgaggccttg      840

gggcgcccgg gaggcctggc cgtgttggcc gcctttctgg aggagggccc ggaagaaaac      900

agtgcctatg agcagttgct gtctcgcttg gaagaaatcg ctgaggaagg ctcagagact      960

caggtcccag gactggacat atctgcactc ctgccctctg acttcagccg ctacttccaa     1020

tatgaggggt ctctgactac accgccctgt gcccagggtg tcatctggac tgtgtttaac     1080

cagacagtga tgctgagtgc taagcagtcc tagccctggt ttttggcctc ctttttgctg     1140

tcaccagcgt cgcgttcctt gtgcagatga gaaggcagca cagaagggga accaaagggg     1200

gtgtgagcta ccgcccagca gaggtagccg agactggagc ctagaggctg gatcttggag     1260

aatgtgagaa gccagccaga ggcatctgag ggggagccgg taactgtcct gtcctgctca     1320

ttatgccact tccttttaac tgccaagaaa ttttttaaaa taaatattta taat           1374


<210>  77
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Met Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Ser 
        355     


