                         SEQUENCE LISTING

<110>  CuRNA, Inc.
 
<120>  TREATMENT OF MEMBRANE BOUND TRANSCRIPTION FACTOR PEPTIDASE, SITE 
       1 (MBTPS1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE 
       TRANSCRIPT TO MBTPS1

<130>  MBTPS1

<150>  US61/286924
<151>  2009-12-16

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  4354
<212>  DNA
<213>  Homo sapiens

<300>
<308>  NM_003791
<309>  2010-09-21
<313>  (1)..(4354)

<400>  1
gacagacagg gcacgctggg tcggcggagc tgaggctccc agctgtgggc ctcgctggcc       60

cggtcgccca gtctcgcgag agttgggagt aaacagcccc gaatggagtg cccaggcgtg      120

ttcgccgcgg aggcgccgtt atcccgggcc cgccggccct gagctcccgg cggcgcagat      180

tggctcacag tggttgattg atcaacccca ttggacgttg gttctgtggt acaaatggag      240

tacaggactc agtcgtcacg gcctgagtga gagaagcctt atttccaaga tggagaagaa      300

gcggagaaag aaatgaaagc ctctcttcag gctgaaccac aaaaggccat gggatttaac      360

ttttatttat gttgggcaag actgtaagat ggctgattag taatgttgca gcttttagct      420

gaaacaaaaa ttcactttta atcaagaaga aaaaagtgtg atttgaatat atgcaatttt      480

atgatcatat tcgcttgtga ccatgaagct tgtcaacatc tggctgcttc tgctcgtggt      540

tttgctctgt gggaagaaac atctgggcga cagactggaa aagaaatctt ttgaaaaggc      600

cccatgccct ggctgttccc acctgacttt gaaggtggaa ttctcatcaa cagttgtgga      660

atatgaatat attgtggctt tcaatggata ctttacagcc aaagctagaa attcatttat      720

ttcaagtgcc ctgaagagca gtgaagtaga caattggaga attatacctc gaaacaatcc      780

atccagtgac taccctagtg attttgaggt gattcagata aaagaaaaac agaaagcggg      840

gctgctaaca cttgaagatc atccaaacat caaacgggtc acgccccaac gaaaagtctt      900

tcgttccctc aagtatgctg aatctgaccc cacagtaccc tgcaatgaaa cccggtggag      960

ccagaagtgg caatcatcac gtcccctgcg aagagccagc ctctccctgg gctctggctt     1020

ctggcatgct acgggaaggc attcgagcag acggctgctg agagccatcc cgcgccaggt     1080

tgcccagaca ctgcaggcag atgtgctctg gcagatggga tatacaggtg ctaatgtaag     1140

agttgctgtt tttgacactg ggctgagcga gaagcatccc cacttcaaaa atgtgaagga     1200

gagaaccaac tggaccaacg agcgaacgct ggacgatggg ttgggccatg gcacattcgt     1260

ggcaggtgtg atagccagca tgagggagtg ccaaggattt gctccagatg cagaacttca     1320

cattttcagg gtctttacca ataatcaggt atcttacaca tcttggtttt tggacgcctt     1380

caactatgcc attttaaaga agatcgacgt gttaaacctc agcatcggcg gcccggactt     1440

catggatcat ccgtttgttg acaaggtgtg ggaattaaca gctaacaatg taatcatggt     1500

ttctgctatt ggcaatgacg gacctcttta tggcactctg aataaccctg ctgatcaaat     1560

ggatgtgatt ggagtaggcg gcattgactt tgaagataac atcgcccgct tttcttcaag     1620

gggaatgact acctgggagc taccaggagg ctacggtcgc atgaaacctg acattgtcac     1680

ctatggtgct ggcgtgcggg gttctggcgt gaaagggggg tgccgggccc tctcagggac     1740

cagtgttgct tctccagtgg ttgcaggtgc tgtcaccttg ttagtgagca cagtccagaa     1800

gcgtgagctg gtgaatcccg ccagtatgaa gcaggccctg atcgcgtcag cccggaggct     1860

ccccggggtc aacatgtttg agcaaggcca cggcaagctc gatctgctca gagcctatca     1920

gatcctcaac agctacaagc cacaggcaag tttgagcccc agctacatag atctgactga     1980

gtgtccctac atgtggccct actgctccca gcccatctac tatggaggaa tgccgacagt     2040

tgttaatgtc accatcctca acggcatggg agtcacagga agaattgtag ataagcctga     2100

ctggcagccc tatttgccac agaacggaga caacattgaa gttgccttct cctactcctc     2160

ggtcttatgg ccttggtcgg gctacctggc catctccatt tctgtgacca agaaagcggc     2220

ttcctgggaa ggcattgctc agggccatgt catgatcact gtggcttccc cagcagagac     2280

agagtcaaaa aatggtgcag aacagacttc aacagtaaag ctccccatta aggtgaagat     2340

aattcctact cccccgcgaa gcaagagagt tctctgggat cagtaccaca acctccgcta     2400

tccacctggc tatttcccca gggataattt aaggatgaag aatgaccctt tagactggaa     2460

tggtgatcac atccacacca atttcaggga tatgtaccag catctgagaa gcatgggcta     2520

ctttgtagag gtcctcgggg cccccttcac gtgttttgat gccagtcagt atggcacttt     2580

gctgatggtg gacagtgagg aggagtactt ccctgaagag atcgccaagc tccggaggga     2640

cgtggacaac ggcctctcgc tcgtcatctt cagtgactgg tacaacactt ctgttatgag     2700

aaaagtgaag ttttatgatg aaaacacaag gcagtggtgg atgccggata ccggaggagc     2760

taacatccca gctctgaatg agctgctgtc tgtgtggaac atggggttca gcgatggcct     2820

gtatgaaggg gagttcaccc tggccaacca tgacatgtat tatgcgtcag ggtgcagcat     2880

cgcgaagttt ccagaagatg gcgtcgtgat aacacagact ttcaaggacc aaggattgga     2940

ggttttaaag caggaaacag cagttgttga aaacgtcccc attttgggac tttatcagat     3000

tccagctgag ggtggaggcc ggattgtact gtatggggac tccaattgct tggatgacag     3060

tcaccgacag aaggactgct tttggcttct ggatgccctc ctccagtaca catcgtatgg     3120

ggtgacaccg cctagcctca gtcactctgg gaaccgccag cgccctccca gtggagcagg     3180

ctcagtcact ccagagagga tggaaggaaa ccatcttcat cggtactcca aggttctgga     3240

ggcccatttg ggagacccaa aacctcggcc tctaccagcc tgtccacgct tgtcttgggc     3300

caagccacag cctttaaacg agacggcgcc cagtaacctt tggaaacatc agaagctact     3360

ctccattgac ctggacaagg tggtgttacc caactttcga tcgaatcgcc ctcaagtgag     3420

gcccttgtcc cctggagaga gcggcgcctg ggacattcct ggagggatca tgcctggccg     3480

ctacaaccag gaggtgggcc agaccattcc tgtctttgcc ttcctgggag ccatggtggt     3540

cctggccttc tttgtggtac aaatcaacaa ggccaagagc aggccgaagc ggaggaagcc     3600

cagggtgaag cgcccgcagc tcatgcagca ggttcacccg ccaaagaccc cttcggtgtg     3660

accggcagcc tggctgaccg tgagggccag agagagcctt cacggacggc gctggtgggt     3720

gagccgagct gtggtggcgg ctggtttaaa agggatccag tttccagctg caggtttgtt     3780

agagtctgtt ctacatgggc ctgccctcct gtgatgggca gaggctcctg gtacatcgag     3840

aagattcctg tggatcccgt caggagggac ttagtggctc tgccgccagt gagacttccc     3900

gccggcagct gtgcgcacca aagactcggg agaactggaa aggctgtctg gggtcttctg     3960

actgcagggg aaggatgtac tttccaaaca aatgatacaa ccctgaccaa gctaaaagac     4020

gcttgttaaa ggctattttc tatatttatt gttgggaaaa gtcactttaa agacttgtgc     4080

tatttggaag caaagctatt ttttttgtca gtggaatgca gtttttttac tattccatca     4140

tgaggaacaa catagattcc atgatctttt taatgacagt acagactgag atttgaagga     4200

aacatgcaca aatctgtaaa acatagacct tcgctttatt tttgtaagta tcacctgcca     4260

ccatgttttg taatttgagg tcttgatttc accattgtcg gtgaagaaaa ttttcaataa     4320

atatgtatta cccgtctgaa gcttaaaaaa aaaa                                 4354


<210>  2
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  2
tgccaggcgg cgagaacgcg ctgggggaac ccttggtccg ctctgcgcgt cgctctagga       60

tccccgaaaa ggagcacggg cgcgaaagcg gccaggctgg gccaggatct agaaagactg      120

cctggcgcag gctccctgcc cccgcgggcc tgctgtcatg gactcgtgga gagctcgctt      180

cccgcgcgga cccttcctgc aggggtccac gtccaggcac cggcggctcg gacaccccac      240

ccccggccgg gcacctgccc tgggtgcccc ttaacccggg cggtagctcg ttaagatggc      300

gaagtgtccg gtccggaaca cgcgaaaccc caaatcccgc ctgcccgacc tcctgacccc      360

cggccccacg ggacgacaga ctgggcctcc cgacgcgcag cgcgctgccg ggacaccggg      420

tgcgtgcgaa acggcaggac cctttgtaac gccacgtgtc ttgctctttc ttgacaaaac      480

cagaataaat gcgctcaact ggcctgaaaa aggtctgccc gcctaataaa aaaaaaaaaa      540

cgggcgcgtc ggctcctagc agcatccccc cccagggggc cccaagcgtt taggcggtaa      600

cccccggttt ttgctttgtt acaaaaccga gggtccccct tataagggcg agggtcgcga      660

cattcacata cacgcccggc cggctacctt gggttccgcg tcgcccctgt tccaccagag      720

cgcgcccatg tgtgatactt ggggcgagac aacaaacacg tgtgattaca ggactctggg      780

ggggcgaaca cctcaccctc gcttgagaat aacgggaata cccccccttc acgttattcc      840

ctacgggggg gggggggggc ggcggaaaac aattacgtct gtcggtggga caccgcgcac      900

atgtacacga cctggagagc gggaaggtaa tattgtctaa aataaagccg cgccctttag      960

cggcgcgcgc acgaacatat gtcatacacc aatgtccctt gtctcacaca cccggaacac     1020

gacagcaaag gcgggggcgg tccaaacagg atcgaggcca cgcgctctgc ttaacgaggc     1080

actcgctggc gctgcaccct ccttcgacgc tgagaatcta tttcgtgcgc gtcatcctgt     1140

gaacaagccg actagggagg atatgttccc ggccaacacc cgcggtcatc ctctccgcgc     1200

gcacagtgcg cgcgcgcgct cctcggagtg ccccgctaat                           1240


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  3
gaccggacac ttcgccatct                                                   20


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  4
gcagtctttc tagatcctgg c                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  5
ctccacgagt ccatgacagc a                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  6
gcgccaggca gtctttctag a                                                 21


